Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.21 0.29 -9999.0 0.0 -0.596 53.0 53.0 IHH -0.244 0.285 -9999.0 0.0 -0.564 80.0 80.0 SHH Np/Cholesterol/GAS1 -0.094 0.137 -9999.0 0.0 -0.587 3.0 3.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.093 0.136 0.582 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.204 0.26 -9999.0 0.0 -0.54 52.0 52.0 SMO -0.221 0.273 -9999.0 0.0 -0.543 65.0 65.0 AKT1 -0.079 0.122 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.004 0.09 -9999.0 0.0 -0.496 6.0 6.0 ADRBK1 0.008 0.058 -9999.0 0.0 -0.783 1.0 1.0 heart looping -0.218 0.269 -9999.0 0.0 -0.535 65.0 65.0 STIL -0.251 0.266 -9999.0 0.0 -0.636 38.0 38.0 DHH N/PTCH2 -0.008 0.067 -9999.0 0.0 -0.513 3.0 3.0 DHH N/PTCH1 -0.152 0.208 -9999.0 0.0 -0.435 49.0 49.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.012 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.348 0.447 -9999.0 0.0 -0.902 65.0 65.0 determination of left/right symmetry -0.218 0.269 -9999.0 0.0 -0.535 65.0 65.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.343 0.441 -9999.0 0.0 -0.889 65.0 65.0 IHH N/Hhip -0.308 0.251 -9999.0 0.0 -0.486 108.0 108.0 DHH N/Hhip -0.163 0.174 -9999.0 0.0 -0.348 86.0 86.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.218 0.269 -9999.0 0.0 -0.535 65.0 65.0 pancreas development -0.225 0.252 -9999.0 0.0 -0.495 86.0 86.0 HHAT 0.001 0.074 -9999.0 0.0 -0.496 4.0 4.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.014 0.118 -9999.0 0.0 -0.528 9.0 9.0 somite specification -0.218 0.269 -9999.0 0.0 -0.535 65.0 65.0 SHH Np/Cholesterol/PTCH1 -0.204 0.255 -9999.0 0.0 -0.552 48.0 48.0 SHH Np/Cholesterol/PTCH2 -0.086 0.137 -9999.0 0.0 -0.558 4.0 4.0 SHH Np/Cholesterol/Megalin -0.095 0.142 -9999.0 0.0 -0.484 8.0 8.0 SHH -0.092 0.177 -9999.0 0.0 -0.359 55.0 55.0 catabolic process -0.178 0.232 -9999.0 0.0 -0.49 50.0 50.0 SMO/Vitamin D3 -0.225 0.277 -9999.0 0.0 -0.574 55.0 55.0 SHH Np/Cholesterol/Hhip -0.202 0.191 -9999.0 0.0 -0.52 34.0 34.0 LRP2 -0.015 0.141 -9999.0 0.0 -0.783 6.0 6.0 receptor-mediated endocytosis -0.244 0.239 -9999.0 0.0 -0.585 46.0 46.0 SHH Np/Cholesterol/BOC -0.088 0.136 -9999.0 0.0 -0.601 3.0 3.0 SHH Np/Cholesterol/CDO -0.09 0.136 -9999.0 0.0 -0.51 5.0 5.0 mesenchymal cell differentiation 0.2 0.19 0.516 34.0 -9999.0 0.0 34.0 mol:Vitamin D3 -0.203 0.257 -9999.0 0.0 -0.554 48.0 48.0 IHH N/PTCH2 -0.144 0.193 -9999.0 0.0 -0.384 50.0 50.0 CDON -0.006 0.101 -9999.0 0.0 -0.544 6.0 6.0 IHH N/PTCH1 -0.18 0.234 -9999.0 0.0 -0.495 50.0 50.0 Megalin/LRPAP1 -0.019 0.106 -9999.0 0.0 -0.596 6.0 6.0 PTCH2 0.001 0.09 -9999.0 0.0 -0.687 3.0 3.0 SHH Np/Cholesterol -0.082 0.129 -9999.0 0.0 -0.527 2.0 2.0 PTCH1 -0.179 0.233 -9999.0 0.0 -0.491 50.0 50.0 HHIP -0.226 0.253 -9999.0 0.0 -0.496 86.0 86.0