Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within FOXA2 and FOXA3 transcription factor networks 63.0 2923.0 46.0 -1.249 0.019 1000.0 -1000.0 -0.13 -1000.0 Ephrin A reverse signaling 51.0 360.0 7.0 -0.231 0.004 1000.0 -1000.0 -0.032 -1000.0 Syndecan-1-mediated signaling events 41.0 1397.0 34.0 -0.39 0.012 1000.0 -1000.0 -0.077 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 38.0 3025.0 78.0 -0.452 0.153 1000.0 -1000.0 -0.094 -1000.0 Signaling events mediated by the Hedgehog family 32.0 1685.0 52.0 -0.348 0.2 1000.0 -1000.0 -0.086 -1000.0 Osteopontin-mediated events 31.0 1192.0 38.0 -0.437 0.014 1000.0 -1000.0 -0.124 -1000.0 IL23-mediated signaling events 31.0 1888.0 60.0 -0.632 0.012 1000.0 -1000.0 -0.203 -1000.0 TCGA08_retinoblastoma 30.0 240.0 8.0 -0.157 0.053 1000.0 -1000.0 -0.028 -1000.0 Ephrin B reverse signaling 24.0 1193.0 48.0 -0.233 0.217 1000.0 -1000.0 -0.076 -1000.0 Aurora B signaling 24.0 1619.0 67.0 -0.353 0.012 1000.0 -1000.0 -0.082 -1000.0 Glucocorticoid receptor regulatory network 21.0 2504.0 114.0 -0.767 0.377 1000.0 -1000.0 -0.073 -1000.0 Glypican 2 network 20.0 81.0 4.0 -0.092 -1000.0 1000.0 -1000.0 -0.039 -1000.0 Glypican 1 network 19.0 914.0 48.0 -0.27 0.031 1000.0 -1000.0 -0.057 -1000.0 S1P5 pathway 19.0 337.0 17.0 -0.381 0.152 1000.0 -1000.0 -0.064 -1000.0 LPA receptor mediated events 19.0 1968.0 102.0 -0.417 0.036 1000.0 -1000.0 -0.106 -1000.0 FOXM1 transcription factor network 19.0 999.0 51.0 -0.34 0.021 1000.0 -1000.0 -0.23 -1000.0 EPHB forward signaling 18.0 1568.0 85.0 -0.239 0.18 1000.0 -1000.0 -0.106 -1000.0 Effects of Botulinum toxin 18.0 477.0 26.0 -0.372 0.015 1000.0 -1000.0 -0.073 -1000.0 Reelin signaling pathway 17.0 960.0 56.0 -0.268 0.012 1000.0 -1000.0 -0.087 -1000.0 Syndecan-2-mediated signaling events 15.0 1070.0 69.0 -0.502 0.043 1000.0 -1000.0 -0.066 -1000.0 IL4-mediated signaling events 14.0 1337.0 91.0 -0.782 0.507 1000.0 -1000.0 -0.201 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 13.0 709.0 54.0 -0.234 0.026 1000.0 -1000.0 -0.113 -1000.0 p75(NTR)-mediated signaling 13.0 1643.0 125.0 -0.519 0.012 1000.0 -1000.0 -0.121 -1000.0 Nectin adhesion pathway 13.0 866.0 63.0 -0.467 0.024 1000.0 -1000.0 -0.088 -1000.0 Wnt signaling 13.0 92.0 7.0 -0.211 0.012 1000.0 -1000.0 -0.031 -1000.0 amb2 Integrin signaling 12.0 1040.0 82.0 -0.282 0.012 1000.0 -1000.0 -0.102 -1000.0 IL1-mediated signaling events 12.0 765.0 62.0 -0.385 0.062 1000.0 -1000.0 -0.108 -1000.0 TCGA08_p53 12.0 88.0 7.0 -0.116 0.055 1000.0 -1000.0 -0.021 -1000.0 Syndecan-3-mediated signaling events 12.0 440.0 35.0 -0.502 0.012 1000.0 -1000.0 -0.071 -1000.0 S1P4 pathway 12.0 301.0 25.0 -0.381 0.021 1000.0 -1000.0 -0.065 -1000.0 Sphingosine 1-phosphate (S1P) pathway 11.0 329.0 28.0 -0.381 0.016 1000.0 -1000.0 -0.063 -1000.0 Signaling events regulated by Ret tyrosine kinase 11.0 936.0 82.0 -0.227 0.012 1000.0 -1000.0 -0.102 -1000.0 Endothelins 11.0 1091.0 96.0 -0.325 0.108 1000.0 -1000.0 -0.101 -1000.0 Aurora C signaling 10.0 74.0 7.0 -0.139 0.003 1000.0 -1000.0 -0.046 -1000.0 PLK1 signaling events 10.0 857.0 85.0 -0.269 0.014 1000.0 -1000.0 -0.061 -1000.0 Canonical Wnt signaling pathway 10.0 549.0 51.0 -0.321 0.071 1000.0 -1000.0 -0.067 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 10.0 722.0 68.0 -0.549 0.032 1000.0 -1000.0 -0.148 -1000.0 EGFR-dependent Endothelin signaling events 10.0 228.0 21.0 -0.113 0.012 1000.0 -1000.0 -0.08 -1000.0 E-cadherin signaling events 10.0 54.0 5.0 -0.096 0.012 1000.0 -1000.0 -0.048 -1000.0 LPA4-mediated signaling events 9.0 118.0 12.0 -0.064 0.02 1000.0 -1000.0 -0.028 -1000.0 Coregulation of Androgen receptor activity 9.0 712.0 76.0 -0.4 0.024 1000.0 -1000.0 -0.063 -1000.0 ErbB4 signaling events 9.0 669.0 69.0 -0.243 0.148 1000.0 -1000.0 -0.099 -1000.0 Visual signal transduction: Cones 9.0 362.0 38.0 -0.176 0.014 1000.0 -1000.0 -0.076 -1000.0 Signaling events mediated by PTP1B 9.0 732.0 76.0 -0.291 0.047 1000.0 -1000.0 -0.099 -1000.0 Aurora A signaling 9.0 572.0 60.0 -0.291 0.045 1000.0 -1000.0 -0.08 -1000.0 BMP receptor signaling 9.0 758.0 81.0 -0.237 0.036 1000.0 -1000.0 -0.1 -1000.0 Nongenotropic Androgen signaling 9.0 491.0 52.0 -0.139 0.012 1000.0 -1000.0 -0.067 -1000.0 Syndecan-4-mediated signaling events 9.0 666.0 67.0 -0.372 0.034 1000.0 -1000.0 -0.1 -1000.0 Visual signal transduction: Rods 9.0 479.0 52.0 -0.248 0.012 1000.0 -1000.0 -0.097 -1000.0 Noncanonical Wnt signaling pathway 8.0 208.0 26.0 -0.211 0.012 1000.0 -1000.0 -0.086 -1000.0 Presenilin action in Notch and Wnt signaling 8.0 505.0 61.0 -0.321 0.034 1000.0 -1000.0 -0.078 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 8.0 1060.0 120.0 -0.41 0.112 1000.0 -1000.0 -0.084 -1000.0 EPO signaling pathway 7.0 392.0 55.0 -0.123 0.027 1000.0 -1000.0 -0.105 -1000.0 TRAIL signaling pathway 7.0 356.0 48.0 -0.056 0.028 1000.0 -1000.0 -0.079 -1000.0 Signaling mediated by p38-alpha and p38-beta 7.0 349.0 44.0 -0.202 0.012 1000.0 -1000.0 -0.059 -1000.0 Integrins in angiogenesis 7.0 612.0 84.0 -0.437 0.037 1000.0 -1000.0 -0.122 -1000.0 Calcium signaling in the CD4+ TCR pathway 7.0 247.0 31.0 -0.277 0.013 1000.0 -1000.0 -0.099 -1000.0 IL12-mediated signaling events 6.0 595.0 87.0 -0.216 0.027 1000.0 -1000.0 -0.16 -1000.0 HIF-1-alpha transcription factor network 6.0 488.0 76.0 -0.319 0.042 1000.0 -1000.0 -0.209 -1000.0 Arf6 signaling events 6.0 420.0 62.0 -0.238 0.021 1000.0 -1000.0 -0.082 -1000.0 Fc-epsilon receptor I signaling in mast cells 6.0 596.0 97.0 -0.1 0.028 1000.0 -1000.0 -0.108 -1000.0 Regulation of Androgen receptor activity 6.0 470.0 70.0 -0.56 0.026 1000.0 -1000.0 -0.076 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 5.0 190.0 34.0 -0.033 0.021 1000.0 -1000.0 -0.071 -1000.0 IL2 signaling events mediated by PI3K 5.0 315.0 58.0 -0.147 0.053 1000.0 -1000.0 -0.102 -1000.0 BCR signaling pathway 5.0 592.0 99.0 -0.098 0.03 1000.0 -1000.0 -0.1 -1000.0 ErbB2/ErbB3 signaling events 4.0 311.0 65.0 -0.155 0.025 1000.0 -1000.0 -0.079 -1000.0 Caspase cascade in apoptosis 4.0 331.0 74.0 -0.187 0.025 1000.0 -1000.0 -0.066 -1000.0 PLK2 and PLK4 events 4.0 12.0 3.0 -0.014 0.002 1000.0 -1000.0 -0.023 -1000.0 Thromboxane A2 receptor signaling 4.0 488.0 105.0 -0.238 0.04 1000.0 -1000.0 -0.088 -1000.0 IFN-gamma pathway 4.0 289.0 68.0 -0.129 0.036 1000.0 -1000.0 -0.109 -1000.0 TCR signaling in naïve CD8+ T cells 4.0 422.0 93.0 -0.184 0.106 1000.0 -1000.0 -0.101 -1000.0 IL27-mediated signaling events 4.0 254.0 51.0 -0.106 0.012 1000.0 -1000.0 -0.087 -1000.0 Plasma membrane estrogen receptor signaling 4.0 348.0 86.0 -0.238 0.04 1000.0 -1000.0 -0.095 -1000.0 Angiopoietin receptor Tie2-mediated signaling 4.0 411.0 88.0 -0.127 0.053 1000.0 -1000.0 -0.112 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 4.0 161.0 33.0 -0.222 0.038 1000.0 -1000.0 -0.076 -1000.0 Regulation of nuclear SMAD2/3 signaling 3.0 459.0 136.0 -0.216 0.079 1000.0 -1000.0 -0.092 -1000.0 BARD1 signaling events 3.0 213.0 57.0 -0.277 0.039 1000.0 -1000.0 -0.085 -1000.0 Hedgehog signaling events mediated by Gli proteins 3.0 218.0 65.0 -0.438 0.07 1000.0 -1000.0 -0.076 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 3.0 140.0 37.0 -0.148 0.044 1000.0 -1000.0 -0.065 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 3.0 185.0 52.0 -0.079 0.02 1000.0 -1000.0 -0.079 -1000.0 S1P1 pathway 3.0 108.0 36.0 -0.096 0.018 1000.0 -1000.0 -0.068 -1000.0 Retinoic acid receptors-mediated signaling 3.0 190.0 58.0 -0.1 0.029 1000.0 -1000.0 -0.088 -1000.0 Regulation of p38-alpha and p38-beta 3.0 183.0 54.0 -0.194 0.012 1000.0 -1000.0 -0.068 -1000.0 IL6-mediated signaling events 3.0 252.0 75.0 -0.341 0.06 1000.0 -1000.0 -0.12 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 3.0 233.0 74.0 -0.123 0.061 1000.0 -1000.0 -0.105 -1000.0 VEGFR1 specific signals 3.0 214.0 56.0 -0.1 0.04 1000.0 -1000.0 -0.088 -1000.0 S1P3 pathway 3.0 164.0 42.0 -0.238 0.027 1000.0 -1000.0 -0.073 -1000.0 Canonical NF-kappaB pathway 2.0 115.0 39.0 -0.139 0.07 1000.0 -1000.0 -0.107 -1000.0 JNK signaling in the CD4+ TCR pathway 2.0 38.0 17.0 -0.022 0.04 1000.0 -1000.0 -0.077 -1000.0 Insulin-mediated glucose transport 2.0 71.0 32.0 -0.267 0.032 1000.0 -1000.0 -0.08 -1000.0 Ceramide signaling pathway 2.0 224.0 76.0 -0.139 0.023 1000.0 -1000.0 -0.074 -1000.0 Signaling events mediated by HDAC Class III 2.0 111.0 40.0 -0.093 0.023 1000.0 -1000.0 -0.046 -1000.0 Signaling mediated by p38-gamma and p38-delta 2.0 37.0 15.0 -0.005 0.029 1000.0 -1000.0 -0.035 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 2.0 103.0 45.0 -0.139 0.071 1000.0 -1000.0 -0.103 -1000.0 E-cadherin signaling in the nascent adherens junction 2.0 205.0 76.0 -0.096 0.058 1000.0 -1000.0 -0.104 -1000.0 IL2 signaling events mediated by STAT5 2.0 54.0 22.0 -0.052 0.051 1000.0 -1000.0 -0.079 -1000.0 Class I PI3K signaling events 2.0 174.0 73.0 -0.184 0.033 1000.0 -1000.0 -0.094 -1000.0 Regulation of Telomerase 2.0 256.0 102.0 -0.15 0.048 1000.0 -1000.0 -0.124 -1000.0 Signaling events mediated by PRL 2.0 75.0 34.0 -0.08 0.041 1000.0 -1000.0 -0.049 -1000.0 Cellular roles of Anthrax toxin 1.0 63.0 39.0 -0.139 0.02 1000.0 -1000.0 -0.038 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 1.0 122.0 85.0 -0.024 0.054 1000.0 -1000.0 -0.088 -1000.0 PDGFR-alpha signaling pathway 1.0 70.0 44.0 -0.018 0.036 1000.0 -1000.0 -0.064 -1000.0 Class I PI3K signaling events mediated by Akt 1.0 68.0 68.0 -0.267 0.049 1000.0 -1000.0 -0.076 -1000.0 ceramide signaling pathway 1.0 83.0 49.0 -0.138 0.03 1000.0 -1000.0 -0.06 -1000.0 HIF-2-alpha transcription factor network 1.0 66.0 43.0 -0.079 0.08 1000.0 -1000.0 -0.117 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 1.0 119.0 83.0 -0.267 0.06 1000.0 -1000.0 -0.098 -1000.0 Signaling events mediated by HDAC Class I 1.0 175.0 104.0 -0.139 0.057 1000.0 -1000.0 -0.069 -1000.0 FoxO family signaling 1.0 91.0 64.0 -0.267 0.125 1000.0 -1000.0 -0.106 -1000.0 FAS signaling pathway (CD95) 1.0 89.0 47.0 -0.042 0.031 1000.0 -1000.0 -0.056 -1000.0 TCGA08_rtk_signaling 1.0 26.0 26.0 -0.036 0.047 1000.0 -1000.0 -0.026 -1000.0 IGF1 pathway 1.0 107.0 57.0 -0.039 0.037 1000.0 -1000.0 -0.116 -1000.0 Insulin Pathway 1.0 75.0 74.0 -0.054 0.039 1000.0 -1000.0 -0.111 -1000.0 PDGFR-beta signaling pathway 1.0 134.0 97.0 -0.19 0.064 1000.0 -1000.0 -0.1 -1000.0 E-cadherin signaling in keratinocytes 1.0 81.0 43.0 -0.096 0.024 1000.0 -1000.0 -0.08 -1000.0 Ras signaling in the CD4+ TCR pathway 1.0 33.0 17.0 -0.011 0.046 1000.0 -1000.0 -0.051 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 0.0 23.0 0.0 0.046 1000.0 -1000.0 -0.082 -1000.0 Signaling events mediated by HDAC Class II 0.0 25.0 75.0 -0.013 0.034 1000.0 -1000.0 -0.07 -1000.0 Circadian rhythm pathway 0.0 5.0 22.0 -0.014 0.052 1000.0 -1000.0 -0.067 -1000.0 a4b1 and a4b7 Integrin signaling 0.0 0.0 5.0 0.0 0.012 1000.0 -1000.0 -0.041 -1000.0 Arf6 downstream pathway 0.0 30.0 43.0 -0.028 0.028 1000.0 -1000.0 -0.05 -1000.0 mTOR signaling pathway 0.0 0.0 53.0 -0.0 0.034 1000.0 -1000.0 -0.073 -1000.0 Paxillin-dependent events mediated by a4b1 0.0 8.0 36.0 -0.007 0.023 1000.0 -1000.0 -0.085 -1000.0 Atypical NF-kappaB pathway 0.0 11.0 31.0 -0.031 0.039 1000.0 -1000.0 -0.063 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 0.0 98.0 125.0 -0.027 0.093 1000.0 -1000.0 -0.124 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 6.0 27.0 -0.005 0.029 1000.0 -1000.0 -0.064 -1000.0 Arf6 trafficking events 0.0 69.0 71.0 -0.126 0.043 1000.0 -1000.0 -0.088 -1000.0 Rapid glucocorticoid signaling 0.0 9.0 20.0 -0.004 0.012 1000.0 -1000.0 -0.049 -1000.0 Class IB PI3K non-lipid kinase events 0.0 0.0 3.0 -0.012 0.012 1000.0 -1000.0 -0.02 -1000.0 p38 MAPK signaling pathway 0.0 42.0 44.0 -0.081 0.036 1000.0 -1000.0 -0.078 -1000.0 Arf1 pathway 0.0 4.0 54.0 -0.006 0.033 1000.0 -1000.0 -0.046 -1000.0 Alternative NF-kappaB pathway 0.0 0.0 13.0 -0.0 0.012 1000.0 -1000.0 -0.07 -1000.0 Total 1079 60233 7203 -28.1126298404 -993.763305715 131000 -131000 -11.0352898655 -131000