E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.007 0.085 -9999.0 0.0 -0.339 8.0 8.0 KLHL20 0.029 0.072 0.179 8.0 -0.204 2.0 10.0 CYFIP2 -0.047 0.171 -9999.0 0.0 -0.433 30.0 30.0 Rac1/GDP 0.022 0.092 0.266 3.0 -9999.0 0.0 3.0 ENAH -0.017 0.111 -9999.0 0.0 -0.337 13.0 13.0 AP1M1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.021 0.299 1.0 -9999.0 0.0 1.0 RAP1A 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.02 0.057 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.019 0.036 -9999.0 0.0 -0.155 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.064 0.036 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 -0.005 0.117 0.261 3.0 -0.31 10.0 13.0 CTNND1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.125 -9999.0 0.0 -0.343 16.0 16.0 CRK -0.005 0.116 -9999.0 0.0 -0.321 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.045 0.078 0.226 11.0 -0.17 13.0 24.0 alphaE/beta7 Integrin 0.044 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.054 0.024 0.214 1.0 -9999.0 0.0 1.0 DLG1 -0.007 0.086 -9999.0 0.0 -0.342 7.0 7.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.015 0.02 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.047 0.041 0.214 1.0 -0.242 1.0 2.0 PI3K -0.017 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.083 0.227 13.0 -0.2 13.0 26.0 TIAM1 0.024 0.051 0.299 1.0 -0.327 3.0 4.0 E-cadherin(dimer)/Ca2+ 0.056 0.034 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.025 0.069 0.168 26.0 -9999.0 0.0 26.0 PIK3R1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.027 0.035 -9999.0 0.0 -0.433 1.0 1.0 RhoA/GDP 0.026 0.09 0.266 3.0 -9999.0 0.0 3.0 actin cytoskeleton organization 0.024 0.057 0.148 8.0 -0.15 2.0 10.0 CDC42/GDP 0.025 0.093 0.266 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.014 0.051 0.154 11.0 -0.178 5.0 16.0 ITGB7 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.061 0.037 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.044 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.009 0.098 0.269 3.0 -9999.0 0.0 3.0 CDC42/GTP/IQGAP1 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.03 0.106 0.299 13.0 -0.274 12.0 25.0 p120 catenin/RhoA/GDP 0.034 0.09 0.273 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.037 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.013 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.013 0.036 0.115 6.0 -9999.0 0.0 6.0 NME1 0.033 0.02 0.299 1.0 -9999.0 0.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.02 0.115 -9999.0 0.0 -0.341 13.0 13.0 regulation of cell-cell adhesion 0.002 0.037 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.004 0.034 0.104 3.0 -9999.0 0.0 3.0 Rap1/GTP 0.031 0.075 0.251 4.0 -9999.0 0.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.063 0.081 -9999.0 0.0 -0.237 1.0 1.0 CCND1 0.015 0.042 0.132 6.0 -9999.0 0.0 6.0 VAV2 0.019 0.127 -9999.0 0.0 -0.504 1.0 1.0 RAP1/GDP 0.036 0.086 0.272 4.0 -9999.0 0.0 4.0 adherens junction assembly -0.022 0.116 -9999.0 0.0 -0.329 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.046 0.072 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.006 0.03 -9999.0 0.0 -0.258 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.022 0.115 -9999.0 0.0 -0.34 14.0 14.0 PIK3CA 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.013 0.065 -9999.0 0.0 -0.319 2.0 2.0 E-cadherin/beta catenin/alpha catenin 0.05 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.016 0.127 -9999.0 0.0 -0.35 16.0 16.0