Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.127 0.17 -9999.0 0.0 -0.37 43.0 43.0 IHH -0.193 0.249 -9999.0 0.0 -0.478 78.0 78.0 SHH Np/Cholesterol/GAS1 -0.064 0.128 -9999.0 0.0 -0.25 57.0 57.0 LRPAP1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.064 0.127 0.249 57.0 -9999.0 0.0 57.0 SMO/beta Arrestin2 -0.171 0.218 -9999.0 0.0 -0.436 57.0 57.0 SMO -0.184 0.216 -9999.0 0.0 -0.448 60.0 60.0 AKT1 -0.093 0.162 -9999.0 0.0 -0.504 17.0 17.0 ARRB2 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.013 0.083 -9999.0 0.0 -0.433 6.0 6.0 ADRBK1 0.031 0.022 0.299 1.0 -9999.0 0.0 1.0 heart looping -0.182 0.213 -9999.0 0.0 -0.442 60.0 60.0 STIL -0.169 0.19 0.436 1.0 -0.401 58.0 59.0 DHH N/PTCH2 0.04 0.037 -9999.0 0.0 -0.231 3.0 3.0 DHH N/PTCH1 -0.112 0.164 -9999.0 0.0 -0.325 46.0 46.0 PIK3CA 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.182 0.237 -9999.0 0.0 -0.539 41.0 41.0 determination of left/right symmetry -0.182 0.213 -9999.0 0.0 -0.442 60.0 60.0 PIK3R1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.181 0.235 -9999.0 0.0 -0.535 41.0 41.0 IHH N/Hhip -0.249 0.223 -9999.0 0.0 -0.397 119.0 119.0 DHH N/Hhip -0.116 0.176 -9999.0 0.0 -0.312 81.0 81.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.182 0.213 -9999.0 0.0 -0.442 60.0 60.0 pancreas development -0.176 0.228 -9999.0 0.0 -0.432 81.0 81.0 HHAT 0.019 0.068 -9999.0 0.0 -0.433 4.0 4.0 PI3K 0.03 0.023 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.008 0.097 -9999.0 0.0 -0.415 9.0 9.0 somite specification -0.182 0.213 -9999.0 0.0 -0.442 60.0 60.0 SHH Np/Cholesterol/PTCH1 -0.158 0.196 -9999.0 0.0 -0.396 63.0 63.0 SHH Np/Cholesterol/PTCH2 -0.055 0.127 -9999.0 0.0 -0.254 49.0 49.0 SHH Np/Cholesterol/Megalin -0.058 0.122 -9999.0 0.0 -0.25 48.0 48.0 SHH -0.094 0.139 -9999.0 0.0 -0.323 48.0 48.0 catabolic process -0.134 0.172 -9999.0 0.0 -0.322 75.0 75.0 SMO/Vitamin D3 -0.182 0.22 -9999.0 0.0 -0.463 58.0 58.0 SHH Np/Cholesterol/Hhip -0.153 0.176 -9999.0 0.0 -0.31 94.0 94.0 LRP2 0.021 0.054 -9999.0 0.0 -0.274 6.0 6.0 receptor-mediated endocytosis -0.184 0.214 -9999.0 0.0 -0.463 55.0 55.0 SHH Np/Cholesterol/BOC -0.056 0.127 -9999.0 0.0 -0.259 48.0 48.0 SHH Np/Cholesterol/CDO -0.055 0.127 0.189 1.0 -0.253 51.0 52.0 mesenchymal cell differentiation 0.152 0.175 0.308 94.0 -9999.0 0.0 94.0 mol:Vitamin D3 -0.155 0.2 -9999.0 0.0 -0.405 60.0 60.0 IHH N/PTCH2 -0.104 0.167 -9999.0 0.0 -0.296 76.0 76.0 CDON 0.022 0.063 0.299 1.0 -0.433 3.0 4.0 IHH N/PTCH1 -0.128 0.18 -9999.0 0.0 -0.325 75.0 75.0 Megalin/LRPAP1 0.033 0.044 -9999.0 0.0 -0.19 6.0 6.0 PTCH2 0.025 0.047 -9999.0 0.0 -0.327 3.0 3.0 SHH Np/Cholesterol -0.058 0.116 -9999.0 0.0 -0.245 49.0 49.0 PTCH1 -0.135 0.173 -9999.0 0.0 -0.323 75.0 75.0 HHIP -0.176 0.229 -9999.0 0.0 -0.433 81.0 81.0