Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	63.0	2940.0	46.0	-1.08	0.034	1000.0	-1000.0	-0.151	-1000.0
Ephrin A  reverse signaling	60.0	426.0	7.0	-0.18	0.021	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by the Hedgehog family	42.0	2219.0	52.0	-0.249	0.152	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	39.0	3075.0	78.0	-0.457	0.147	1000.0	-1000.0	-0.06	-1000.0
Signaling events regulated by Ret tyrosine kinase	27.0	2255.0	82.0	-0.174	0.038	1000.0	-1000.0	-0.066	-1000.0
Reelin signaling pathway	25.0	1428.0	56.0	-0.125	0.077	1000.0	-1000.0	-0.046	-1000.0
Glypican 1 network	24.0	1154.0	48.0	-0.162	0.043	1000.0	-1000.0	-0.043	-1000.0
S1P5 pathway	20.0	346.0	17.0	-0.119	0.071	1000.0	-1000.0	-0.017	-1000.0
Effects of Botulinum toxin	19.0	508.0	26.0	-0.107	0.03	1000.0	-1000.0	-0.018	-1000.0
Glypican 2 network	19.0	76.0	4.0	0.014	0.023	1000.0	-1000.0	0.008	-1000.0
p75(NTR)-mediated signaling	17.0	2178.0	125.0	-0.176	0.078	1000.0	-1000.0	-0.077	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	16.0	896.0	54.0	-0.119	0.042	1000.0	-1000.0	-0.063	-1000.0
S1P4 pathway	15.0	378.0	25.0	-0.119	0.046	1000.0	-1000.0	-0.033	-1000.0
Visual signal transduction: Cones	14.0	552.0	38.0	-0.065	0.05	1000.0	-1000.0	-0.032	-1000.0
Ephrin B reverse signaling	14.0	690.0	48.0	-0.115	0.035	1000.0	-1000.0	-0.037	-1000.0
Canonical Wnt signaling pathway	14.0	726.0	51.0	-0.114	0.232	1000.0	-1000.0	-0.048	-1000.0
Nongenotropic Androgen signaling	14.0	744.0	52.0	-0.108	0.039	1000.0	-1000.0	-0.046	-1000.0
TCGA08_retinoblastoma	14.0	117.0	8.0	-0.038	0.062	1000.0	-1000.0	-0.01	-1000.0
Syndecan-2-mediated signaling events	13.0	915.0	69.0	-0.154	0.053	1000.0	-1000.0	-0.037	-1000.0
BMP receptor signaling	13.0	1118.0	81.0	-0.195	0.053	1000.0	-1000.0	-0.058	-1000.0
Aurora B signaling	13.0	916.0	67.0	-0.261	0.044	1000.0	-1000.0	-0.047	-1000.0
Coregulation of Androgen receptor activity	12.0	981.0	76.0	-0.373	0.057	1000.0	-1000.0	-0.031	-1000.0
Syndecan-1-mediated signaling events	12.0	437.0	34.0	-0.117	0.034	1000.0	-1000.0	-0.052	-1000.0
Fc-epsilon receptor I signaling in mast cells	12.0	1205.0	97.0	-0.081	0.042	1000.0	-1000.0	-0.072	-1000.0
Integrins in angiogenesis	12.0	1047.0	84.0	-0.333	0.064	1000.0	-1000.0	-0.049	-1000.0
Wnt signaling	12.0	90.0	7.0	-0.041	0.028	1000.0	-1000.0	-0.026	-1000.0
IL4-mediated signaling events	11.0	1090.0	91.0	-0.56	0.307	1000.0	-1000.0	-0.152	-1000.0
Nectin adhesion pathway	11.0	715.0	63.0	-0.077	0.054	1000.0	-1000.0	-0.062	-1000.0
LPA4-mediated signaling events	10.0	124.0	12.0	-0.069	0.001	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PTP1B	10.0	781.0	76.0	-0.201	0.053	1000.0	-1000.0	-0.051	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	628.0	61.0	-0.11	0.078	1000.0	-1000.0	-0.053	-1000.0
Visual signal transduction: Rods	10.0	525.0	52.0	-0.066	0.032	1000.0	-1000.0	-0.044	-1000.0
Sphingosine 1-phosphate (S1P) pathway	9.0	258.0	28.0	-0.119	0.05	1000.0	-1000.0	-0.035	-1000.0
TCGA08_p53	9.0	69.0	7.0	-0.036	0.03	1000.0	-1000.0	-0.019	-1000.0
EPHB forward signaling	9.0	804.0	85.0	-0.097	0.109	1000.0	-1000.0	-0.073	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	9.0	1094.0	120.0	-0.145	0.073	1000.0	-1000.0	-0.057	-1000.0
E-cadherin signaling events	9.0	48.0	5.0	0.027	0.046	1000.0	-1000.0	0.012	-1000.0
Osteopontin-mediated events	8.0	308.0	38.0	-0.144	0.044	1000.0	-1000.0	-0.053	-1000.0
Noncanonical Wnt signaling pathway	8.0	222.0	26.0	-0.041	0.03	1000.0	-1000.0	-0.052	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	819.0	93.0	-0.119	0.05	1000.0	-1000.0	-0.058	-1000.0
LPA receptor mediated events	8.0	896.0	102.0	-0.138	0.049	1000.0	-1000.0	-0.092	-1000.0
Regulation of Androgen receptor activity	8.0	581.0	70.0	-0.414	0.042	1000.0	-1000.0	-0.055	-1000.0
Arf6 signaling events	7.0	470.0	62.0	-0.067	0.059	1000.0	-1000.0	-0.037	-1000.0
PLK1 signaling events	7.0	654.0	85.0	-0.077	0.056	1000.0	-1000.0	-0.03	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	7.0	260.0	37.0	-0.11	0.073	1000.0	-1000.0	-0.035	-1000.0
Endothelins	7.0	761.0	96.0	-0.254	0.059	1000.0	-1000.0	-0.067	-1000.0
Syndecan-3-mediated signaling events	7.0	245.0	35.0	-0.154	0.078	1000.0	-1000.0	-0.033	-1000.0
IGF1 pathway	7.0	442.0	57.0	-0.038	0.058	1000.0	-1000.0	-0.054	-1000.0
S1P3 pathway	7.0	317.0	42.0	-0.067	0.05	1000.0	-1000.0	-0.039	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	7.0	247.0	33.0	-0.175	0.067	1000.0	-1000.0	-0.034	-1000.0
PDGFR-beta signaling pathway	7.0	682.0	97.0	-0.192	0.069	1000.0	-1000.0	-0.069	-1000.0
ErbB4 signaling events	6.0	443.0	69.0	-0.081	0.078	1000.0	-1000.0	-0.051	-1000.0
HIF-1-alpha transcription factor network	6.0	508.0	76.0	-0.211	0.041	1000.0	-1000.0	-0.126	-1000.0
Aurora A signaling	6.0	408.0	60.0	-0.072	0.062	1000.0	-1000.0	-0.03	-1000.0
Aurora C signaling	6.0	42.0	7.0	-0.025	0.023	1000.0	-1000.0	-0.018	-1000.0
EPO signaling pathway	6.0	346.0	55.0	-0.003	0.072	1000.0	-1000.0	-0.055	-1000.0
amb2 Integrin signaling	6.0	527.0	82.0	-0.069	0.05	1000.0	-1000.0	-0.053	-1000.0
Glucocorticoid receptor regulatory network	6.0	776.0	114.0	-0.253	0.109	1000.0	-1000.0	-0.07	-1000.0
Ceramide signaling pathway	6.0	489.0	76.0	-0.03	0.077	1000.0	-1000.0	-0.043	-1000.0
IL1-mediated signaling events	6.0	422.0	62.0	-0.111	0.045	1000.0	-1000.0	-0.052	-1000.0
S1P1 pathway	6.0	218.0	36.0	-0.067	0.03	1000.0	-1000.0	-0.042	-1000.0
BCR signaling pathway	6.0	657.0	99.0	-0.056	0.044	1000.0	-1000.0	-0.073	-1000.0
Syndecan-4-mediated signaling events	6.0	416.0	67.0	-0.118	0.044	1000.0	-1000.0	-0.051	-1000.0
Plasma membrane estrogen receptor signaling	6.0	584.0	86.0	-0.133	0.061	1000.0	-1000.0	-0.06	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	346.0	65.0	-0.384	0.07	1000.0	-1000.0	-0.056	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	279.0	52.0	-0.041	0.057	1000.0	-1000.0	-0.049	-1000.0
Regulation of p38-alpha and p38-beta	5.0	310.0	54.0	-0.153	0.062	1000.0	-1000.0	-0.056	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	372.0	74.0	-0.097	0.063	1000.0	-1000.0	-0.076	-1000.0
Caspase cascade in apoptosis	4.0	346.0	74.0	-0.067	0.067	1000.0	-1000.0	-0.059	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	-0.02	-1000.0	1000.0	-1000.0	-0.031	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	75.0	17.0	-0.029	0.06	1000.0	-1000.0	-0.036	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	413.0	85.0	-0.013	0.052	1000.0	-1000.0	-0.048	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	332.0	68.0	-0.079	0.062	1000.0	-1000.0	-0.039	-1000.0
TRAIL signaling pathway	4.0	207.0	48.0	-0.003	0.082	1000.0	-1000.0	-0.039	-1000.0
ceramide signaling pathway	4.0	223.0	49.0	-0.028	0.056	1000.0	-1000.0	-0.044	-1000.0
FAS signaling pathway (CD95)	4.0	226.0	47.0	-0.024	0.044	1000.0	-1000.0	-0.051	-1000.0
Retinoic acid receptors-mediated signaling	4.0	247.0	58.0	-0.041	0.054	1000.0	-1000.0	-0.048	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	140.0	31.0	-0.111	0.031	1000.0	-1000.0	-0.056	-1000.0
TCGA08_rtk_signaling	4.0	118.0	26.0	-0.07	0.105	1000.0	-1000.0	-0.026	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	325.0	68.0	-0.189	0.033	1000.0	-1000.0	-0.111	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	348.0	76.0	-0.047	0.064	1000.0	-1000.0	-0.064	-1000.0
EGFR-dependent Endothelin signaling events	4.0	90.0	21.0	-0.031	0.044	1000.0	-1000.0	-0.054	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	405.0	88.0	-0.059	0.044	1000.0	-1000.0	-0.083	-1000.0
ErbB2/ErbB3 signaling events	3.0	257.0	65.0	-0.038	0.051	1000.0	-1000.0	-0.066	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	455.0	136.0	-0.216	0.08	1000.0	-1000.0	-0.043	-1000.0
Canonical NF-kappaB pathway	3.0	131.0	39.0	-0.028	0.059	1000.0	-1000.0	-0.038	-1000.0
IL12-mediated signaling events	3.0	267.0	87.0	-0.052	0.044	1000.0	-1000.0	-0.103	-1000.0
Thromboxane A2 receptor signaling	3.0	366.0	105.0	-0.067	0.042	1000.0	-1000.0	-0.054	-1000.0
mTOR signaling pathway	3.0	196.0	53.0	-0.023	0.064	1000.0	-1000.0	-0.04	-1000.0
IFN-gamma pathway	3.0	230.0	68.0	-0.05	0.051	1000.0	-1000.0	-0.067	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	48.0	15.0	-0.027	0.03	1000.0	-1000.0	-0.04	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	165.0	45.0	-0.028	0.07	1000.0	-1000.0	-0.056	-1000.0
IL27-mediated signaling events	3.0	162.0	51.0	-0.061	0.031	1000.0	-1000.0	-0.076	-1000.0
IL6-mediated signaling events	3.0	266.0	75.0	-0.347	0.047	1000.0	-1000.0	-0.081	-1000.0
Class I PI3K signaling events	3.0	284.0	73.0	-0.118	0.052	1000.0	-1000.0	-0.053	-1000.0
E-cadherin signaling in keratinocytes	3.0	153.0	43.0	-0.039	0.062	1000.0	-1000.0	-0.041	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	61.0	17.0	-0.001	0.051	1000.0	-1000.0	-0.03	-1000.0
BARD1 signaling events	2.0	124.0	57.0	-0.081	0.078	1000.0	-1000.0	-0.05	-1000.0
Cellular roles of Anthrax toxin	2.0	106.0	39.0	-0.028	0.04	1000.0	-1000.0	-0.025	-1000.0
Insulin-mediated glucose transport	2.0	95.0	32.0	-0.079	0.057	1000.0	-1000.0	-0.036	-1000.0
PDGFR-alpha signaling pathway	2.0	113.0	44.0	-0.022	0.064	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by HDAC Class III	2.0	86.0	40.0	-0.057	0.058	1000.0	-1000.0	-0.035	-1000.0
HIF-2-alpha transcription factor network	2.0	96.0	43.0	-0.072	0.074	1000.0	-1000.0	-0.067	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	185.0	83.0	-0.079	0.058	1000.0	-1000.0	-0.04	-1000.0
FoxO family signaling	2.0	171.0	64.0	-0.079	0.071	1000.0	-1000.0	-0.075	-1000.0
IL2 signaling events mediated by PI3K	2.0	157.0	58.0	-0.014	0.091	1000.0	-1000.0	-0.052	-1000.0
IL2 signaling events mediated by STAT5	2.0	51.0	22.0	0.003	0.043	1000.0	-1000.0	-0.06	-1000.0
Arf6 trafficking events	2.0	142.0	71.0	-0.085	0.054	1000.0	-1000.0	-0.033	-1000.0
VEGFR1 specific signals	2.0	135.0	56.0	-0.031	0.057	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by PRL	2.0	94.0	34.0	-0.042	0.062	1000.0	-1000.0	-0.039	-1000.0
FOXM1 transcription factor network	2.0	150.0	51.0	-0.038	0.045	1000.0	-1000.0	-0.163	-1000.0
p38 MAPK signaling pathway	2.0	128.0	44.0	-0.05	0.057	1000.0	-1000.0	-0.033	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	67.0	34.0	-0.033	0.067	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by HDAC Class I	1.0	171.0	104.0	-0.058	0.074	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	82.0	44.0	-0.063	0.031	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	223.0	125.0	-0.006	0.066	1000.0	-1000.0	-0.066	-1000.0
Regulation of Telomerase	1.0	167.0	102.0	-0.024	0.088	1000.0	-1000.0	-0.053	-1000.0
Insulin Pathway	1.0	132.0	74.0	-0.028	0.078	1000.0	-1000.0	-0.069	-1000.0
Arf1 pathway	1.0	70.0	54.0	-0.008	0.04	1000.0	-1000.0	-0.023	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	12.0	23.0	0.003	0.047	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class II	0.0	19.0	75.0	-0.03	0.074	1000.0	-1000.0	-0.035	-1000.0
Circadian rhythm pathway	0.0	5.0	22.0	-0.007	0.066	1000.0	-1000.0	-0.032	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.03	0.046	1000.0	-1000.0	0.011	-1000.0
Arf6 downstream pathway	0.0	35.0	43.0	-0.049	0.052	1000.0	-1000.0	-0.033	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	25.0	36.0	-0.059	0.061	1000.0	-1000.0	-0.046	-1000.0
Atypical NF-kappaB pathway	0.0	20.0	31.0	-0.013	0.038	1000.0	-1000.0	-0.038	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	8.0	27.0	-0.018	0.062	1000.0	-1000.0	-0.042	-1000.0
IL23-mediated signaling events	0.0	54.0	60.0	-0.168	0.033	1000.0	-1000.0	-0.132	-1000.0
Rapid glucocorticoid signaling	0.0	12.0	20.0	-0.012	0.039	1000.0	-1000.0	-0.017	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.031	0.031	1000.0	-1000.0	-0.014	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.078	1000.0	-1000.0	-0.0	-1000.0
Total	1002	57083	7203	-13.6332336488	-992.28515668	131000	-131000	-6.53658772996	-131000