E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.104 0.23 -9999.0 0.0 -0.617 25.0 25.0 KLHL20 -0.049 0.081 -9999.0 0.0 -0.338 2.0 2.0 CYFIP2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.017 0.158 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.104 0.23 -9999.0 0.0 -0.617 25.0 25.0 AP1M1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.009 0.032 -9999.0 0.0 -0.384 1.0 1.0 RAP1A 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.01 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.053 0.115 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.032 0.054 -9999.0 0.0 -0.217 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.122 0.234 -9999.0 0.0 -0.563 32.0 32.0 RAPGEF1 -0.044 0.211 -9999.0 0.0 -0.514 25.0 25.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.108 0.239 -9999.0 0.0 -0.642 25.0 25.0 CRK -0.059 0.228 -9999.0 0.0 -0.569 25.0 25.0 E-cadherin/gamma catenin/alpha catenin -0.101 0.221 -9999.0 0.0 -0.592 25.0 25.0 alphaE/beta7 Integrin -0.038 0.154 -9999.0 0.0 -0.68 8.0 8.0 IQGAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.104 0.23 -9999.0 0.0 -0.617 25.0 25.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.039 0.084 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.007 0.063 -9999.0 0.0 -0.549 2.0 2.0 PI3K -0.051 0.109 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.117 0.253 -9999.0 0.0 -0.68 25.0 25.0 TIAM1 -0.001 0.102 -9999.0 0.0 -0.875 2.0 2.0 E-cadherin(dimer)/Ca2+ -0.088 0.192 -9999.0 0.0 -0.514 25.0 25.0 AKT1 -0.028 0.06 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.005 0.072 -9999.0 0.0 -0.875 1.0 1.0 CDH1 -0.143 0.331 -9999.0 0.0 -0.839 27.0 27.0 RhoA/GDP -0.016 0.159 -9999.0 0.0 -0.37 24.0 24.0 actin cytoskeleton organization -0.036 0.06 -9999.0 0.0 -0.237 2.0 2.0 CDC42/GDP -0.016 0.159 -9999.0 0.0 -0.37 24.0 24.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.062 0.135 -9999.0 0.0 -0.364 25.0 25.0 ITGB7 -0.039 0.201 -9999.0 0.0 -0.821 9.0 9.0 RAC1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.092 0.201 -9999.0 0.0 -0.541 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.089 0.194 -9999.0 0.0 -0.522 25.0 25.0 mol:GDP -0.03 0.185 -9999.0 0.0 -0.441 25.0 25.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.064 0.14 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.013 0.086 -9999.0 0.0 -0.201 19.0 19.0 NME1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.104 0.23 -9999.0 0.0 -0.617 25.0 25.0 regulation of cell-cell adhesion -0.046 0.101 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.017 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.061 0.133 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.115 0.22 -9999.0 0.0 -0.528 32.0 32.0 CCND1 -0.048 0.09 -9999.0 0.0 -0.252 19.0 19.0 VAV2 -0.059 0.228 -9999.0 0.0 -0.553 26.0 26.0 RAP1/GDP -0.061 0.133 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.071 0.234 -9999.0 0.0 -0.593 25.0 25.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.109 0.21 -9999.0 0.0 -0.503 32.0 32.0 E-cadherin/beta catenin -0.091 0.199 -9999.0 0.0 -0.533 25.0 25.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.104 0.23 -9999.0 0.0 -0.617 25.0 25.0 PIK3CA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.079 0.134 -9999.0 0.0 -0.532 3.0 3.0 E-cadherin/beta catenin/alpha catenin -0.101 0.22 -9999.0 0.0 -0.592 25.0 25.0 ITGAE 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.111 0.246 -9999.0 0.0 -0.66 25.0 25.0