Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.309 0.381 -9999.0 0.0 -0.787 41.0 41.0 IHH -0.26 0.357 -9999.0 0.0 -0.677 55.0 55.0 SHH Np/Cholesterol/GAS1 -0.118 0.213 -9999.0 0.0 -0.542 29.0 29.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.117 0.212 0.538 29.0 -9999.0 0.0 29.0 SMO/beta Arrestin2 -0.202 0.239 -9999.0 0.0 -0.598 29.0 29.0 SMO -0.205 0.266 -9999.0 0.0 -0.58 40.0 40.0 AKT1 -0.076 0.121 -9999.0 0.0 -0.702 1.0 1.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.094 0.232 -9999.0 0.0 -0.515 30.0 30.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.202 0.261 -9999.0 0.0 -0.569 40.0 40.0 STIL -0.235 0.259 -9999.0 0.0 -0.599 33.0 33.0 DHH N/PTCH2 -0.063 0.178 -9999.0 0.0 -0.758 7.0 7.0 DHH N/PTCH1 -0.242 0.257 -9999.0 0.0 -0.599 41.0 41.0 PIK3CA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.061 0.202 -9999.0 0.0 -0.531 20.0 20.0 PTHLH -0.394 0.514 -9999.0 0.0 -1.192 37.0 37.0 determination of left/right symmetry -0.202 0.261 -9999.0 0.0 -0.569 40.0 40.0 PIK3R1 0.005 0.072 -9999.0 0.0 -0.875 1.0 1.0 skeletal system development -0.386 0.502 -9999.0 0.0 -1.165 37.0 37.0 IHH N/Hhip -0.345 0.379 -9999.0 0.0 -0.697 69.0 69.0 DHH N/Hhip -0.229 0.297 -9999.0 0.0 -0.71 36.0 36.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.202 0.261 -9999.0 0.0 -0.569 40.0 40.0 pancreas development -0.232 0.355 -9999.0 0.0 -0.665 54.0 54.0 HHAT 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.005 0.055 -9999.0 0.0 -0.68 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.019 0.13 -9999.0 0.0 -0.493 9.0 9.0 somite specification -0.202 0.261 -9999.0 0.0 -0.569 40.0 40.0 SHH Np/Cholesterol/PTCH1 -0.268 0.26 -9999.0 0.0 -0.555 52.0 52.0 SHH Np/Cholesterol/PTCH2 -0.112 0.213 -9999.0 0.0 -0.548 28.0 28.0 SHH Np/Cholesterol/Megalin -0.259 0.282 -9999.0 0.0 -0.596 54.0 54.0 SHH -0.112 0.267 -9999.0 0.0 -0.681 26.0 26.0 catabolic process -0.214 0.265 -9999.0 0.0 -0.572 40.0 40.0 SMO/Vitamin D3 -0.247 0.285 -9999.0 0.0 -0.565 52.0 52.0 SHH Np/Cholesterol/Hhip -0.242 0.313 -9999.0 0.0 -0.637 51.0 51.0 LRP2 -0.267 0.35 -9999.0 0.0 -0.611 67.0 67.0 receptor-mediated endocytosis -0.341 0.29 -9999.0 0.0 -0.764 35.0 35.0 SHH Np/Cholesterol/BOC -0.158 0.245 -9999.0 0.0 -0.579 34.0 34.0 SHH Np/Cholesterol/CDO -0.107 0.21 -9999.0 0.0 -0.548 27.0 27.0 mesenchymal cell differentiation 0.24 0.309 0.63 51.0 -9999.0 0.0 51.0 mol:Vitamin D3 -0.256 0.277 -9999.0 0.0 -0.558 52.0 52.0 IHH N/PTCH2 -0.177 0.253 -9999.0 0.0 -0.637 31.0 31.0 CDON 0.003 0.079 -9999.0 0.0 -0.629 2.0 2.0 IHH N/PTCH1 -0.218 0.269 -9999.0 0.0 -0.581 40.0 40.0 Megalin/LRPAP1 -0.202 0.265 -9999.0 0.0 -0.68 31.0 31.0 PTCH2 -0.006 0.111 -9999.0 0.0 -0.629 4.0 4.0 SHH Np/Cholesterol -0.104 0.21 -9999.0 0.0 -0.556 26.0 26.0 PTCH1 -0.215 0.267 -9999.0 0.0 -0.575 40.0 40.0 HHIP -0.233 0.356 -9999.0 0.0 -0.666 54.0 54.0