E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.072 0.213 -9999.0 0.0 -0.54 25.0 25.0 KLHL20 -0.017 0.103 0.192 1.0 -0.258 5.0 6.0 CYFIP2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.039 0.14 -9999.0 0.0 -0.332 22.0 22.0 ENAH -0.074 0.214 -9999.0 0.0 -0.541 25.0 25.0 AP1M1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.028 0.113 -9999.0 0.0 -0.316 1.0 1.0 ABI1/Sra1/Nap1 -0.033 0.055 -9999.0 0.0 -0.191 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.038 0.196 -9999.0 0.0 -0.416 31.0 31.0 RAPGEF1 -0.064 0.185 -9999.0 0.0 -0.468 25.0 25.0 CTNND1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.074 0.22 -9999.0 0.0 -0.537 27.0 27.0 CRK -0.069 0.199 -9999.0 0.0 -0.507 25.0 25.0 E-cadherin/gamma catenin/alpha catenin -0.033 0.182 -9999.0 0.0 -0.439 25.0 25.0 alphaE/beta7 Integrin 0.01 0.118 -9999.0 0.0 -0.48 8.0 8.0 IQGAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.074 0.214 -9999.0 0.0 -0.54 25.0 25.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.032 0.078 -9999.0 0.0 -0.229 1.0 1.0 MLLT4 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.04 0.04 -9999.0 0.0 -0.403 1.0 1.0 PI3K -0.038 0.102 -9999.0 0.0 -0.299 1.0 1.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.054 0.202 -9999.0 0.0 -0.506 25.0 25.0 TIAM1 0.018 0.057 -9999.0 0.0 -0.67 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.02 0.163 -9999.0 0.0 -0.381 25.0 25.0 AKT1 -0.016 0.066 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.02 0.057 -9999.0 0.0 -0.671 1.0 1.0 CDH1 -0.091 0.259 -9999.0 0.0 -0.67 25.0 25.0 RhoA/GDP -0.042 0.143 -9999.0 0.0 -0.335 24.0 24.0 actin cytoskeleton organization -0.008 0.081 0.152 4.0 -0.193 4.0 8.0 CDC42/GDP -0.04 0.144 -9999.0 0.0 -0.335 24.0 24.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.036 0.123 -9999.0 0.0 -0.307 25.0 25.0 ITGB7 -0.011 0.157 -9999.0 0.0 -0.67 8.0 8.0 RAC1 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.02 0.173 -9999.0 0.0 -0.403 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.028 0.158 -9999.0 0.0 -0.381 25.0 25.0 mol:GDP -0.06 0.16 -9999.0 0.0 -0.389 25.0 25.0 CDC42/GTP/IQGAP1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.034 0.149 -9999.0 0.0 -0.343 24.0 24.0 RAC1/GTP/IQGAP1 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.004 0.073 0.146 5.0 -0.201 8.0 13.0 NME1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.071 0.214 -9999.0 0.0 -0.541 25.0 25.0 regulation of cell-cell adhesion -0.028 0.097 -9999.0 0.0 -0.276 1.0 1.0 WASF2 -0.004 0.04 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.031 0.126 -9999.0 0.0 -0.335 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.028 0.192 -9999.0 0.0 -0.394 31.0 31.0 CCND1 -0.007 0.088 0.175 4.0 -0.251 8.0 12.0 VAV2 -0.096 0.237 -9999.0 0.0 -0.514 35.0 35.0 RAP1/GDP -0.03 0.135 -9999.0 0.0 -0.349 3.0 3.0 adherens junction assembly -0.068 0.206 -9999.0 0.0 -0.522 25.0 25.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.035 0.179 -9999.0 0.0 -0.38 31.0 31.0 E-cadherin/beta catenin -0.063 0.168 -9999.0 0.0 -0.439 25.0 25.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.071 0.213 -9999.0 0.0 -0.541 25.0 25.0 PIK3CA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.072 0.129 -9999.0 0.0 -0.391 8.0 8.0 E-cadherin/beta catenin/alpha catenin -0.033 0.182 -9999.0 0.0 -0.439 25.0 25.0 ITGAE 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.077 0.226 -9999.0 0.0 -0.551 27.0 27.0