Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.226 0.407 -9999.0 0.0 -0.893 36.0 36.0 IHH -0.123 0.304 -9999.0 0.0 -0.635 34.0 34.0 SHH Np/Cholesterol/GAS1 -0.053 0.165 -9999.0 0.0 -0.395 28.0 28.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.164 0.392 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.141 0.237 -9999.0 0.0 -0.5 34.0 34.0 SMO -0.145 0.246 -9999.0 0.0 -0.521 35.0 35.0 AKT1 -0.051 0.138 -9999.0 0.0 -0.69 3.0 3.0 ARRB2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.001 0.162 -9999.0 0.0 -0.67 8.0 8.0 ADRBK1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.148 0.241 -9999.0 0.0 -0.508 36.0 36.0 STIL -0.16 0.23 0.327 1.0 -0.456 37.0 38.0 DHH N/PTCH2 0.014 0.133 -9999.0 0.0 -0.563 7.0 7.0 DHH N/PTCH1 -0.129 0.248 -9999.0 0.0 -0.431 55.0 55.0 PIK3CA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.004 0.14 -9999.0 0.0 -0.67 6.0 6.0 PTHLH -0.247 0.386 -9999.0 0.0 -0.871 35.0 35.0 determination of left/right symmetry -0.148 0.241 -9999.0 0.0 -0.508 36.0 36.0 PIK3R1 0.02 0.057 -9999.0 0.0 -0.67 1.0 1.0 skeletal system development -0.244 0.381 -9999.0 0.0 -0.859 35.0 35.0 IHH N/Hhip -0.162 0.325 -9999.0 0.0 -0.614 47.0 47.0 DHH N/Hhip -0.082 0.25 -9999.0 0.0 -0.522 35.0 35.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.148 0.241 -9999.0 0.0 -0.508 36.0 36.0 pancreas development -0.106 0.285 -9999.0 0.0 -0.659 31.0 31.0 HHAT 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.032 0.045 -9999.0 0.0 -0.506 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.018 0.082 -9999.0 0.0 -0.67 2.0 2.0 somite specification -0.148 0.241 -9999.0 0.0 -0.508 36.0 36.0 SHH Np/Cholesterol/PTCH1 -0.169 0.239 -9999.0 0.0 -0.413 63.0 63.0 SHH Np/Cholesterol/PTCH2 -0.057 0.166 -9999.0 0.0 -0.402 28.0 28.0 SHH Np/Cholesterol/Megalin -0.122 0.244 -9999.0 0.0 -0.445 51.0 51.0 SHH -0.08 0.196 -9999.0 0.0 -0.507 26.0 26.0 catabolic process -0.14 0.243 -9999.0 0.0 -0.444 55.0 55.0 SMO/Vitamin D3 -0.165 0.261 0.473 1.0 -0.484 41.0 42.0 SHH Np/Cholesterol/Hhip -0.126 0.246 -9999.0 0.0 -0.465 47.0 47.0 LRP2 -0.099 0.294 -9999.0 0.0 -0.67 31.0 31.0 receptor-mediated endocytosis -0.224 0.282 -9999.0 0.0 -0.674 30.0 30.0 SHH Np/Cholesterol/BOC -0.063 0.192 -9999.0 0.0 -0.42 32.0 32.0 SHH Np/Cholesterol/CDO -0.056 0.157 -9999.0 0.0 -0.396 26.0 26.0 mesenchymal cell differentiation 0.125 0.244 0.461 47.0 -9999.0 0.0 47.0 mol:Vitamin D3 -0.161 0.252 0.434 1.0 -0.415 63.0 64.0 IHH N/PTCH2 -0.072 0.212 -9999.0 0.0 -0.478 30.0 30.0 CDON 0.016 0.031 -9999.0 0.0 -0.342 1.0 1.0 IHH N/PTCH1 -0.127 0.258 -9999.0 0.0 -0.448 55.0 55.0 Megalin/LRPAP1 -0.062 0.228 -9999.0 0.0 -0.506 31.0 31.0 PTCH2 0.016 0.08 -9999.0 0.0 -0.67 2.0 2.0 SHH Np/Cholesterol -0.059 0.157 -9999.0 0.0 -0.401 26.0 26.0 PTCH1 -0.141 0.243 -9999.0 0.0 -0.445 55.0 55.0 HHIP -0.106 0.285 -9999.0 0.0 -0.66 31.0 31.0