Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.087 0.208 -9999.0 0.0 -0.623 30.0 30.0 IHH -0.15 0.312 -9999.0 0.0 -0.701 119.0 119.0 SHH Np/Cholesterol/GAS1 -0.053 0.158 -9999.0 0.0 -0.395 84.0 84.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.157 0.392 84.0 -9999.0 0.0 84.0 SMO/beta Arrestin2 -0.073 0.205 -9999.0 0.0 -0.417 108.0 108.0 SMO -0.094 0.206 -9999.0 0.0 -0.438 115.0 115.0 AKT1 -0.015 0.105 -9999.0 0.0 -0.609 2.0 2.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.088 -9999.0 0.0 -0.674 8.0 8.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.093 0.204 -9999.0 0.0 -0.431 116.0 116.0 STIL -0.064 0.159 -9999.0 0.0 -0.488 14.0 14.0 DHH N/PTCH2 -0.05 0.204 -9999.0 0.0 -0.511 80.0 80.0 DHH N/PTCH1 -0.075 0.188 -9999.0 0.0 -0.372 127.0 127.0 PIK3CA 0.023 0.054 -9999.0 0.0 -0.674 3.0 3.0 DHH 0.021 0.063 -9999.0 0.0 -0.674 4.0 4.0 PTHLH -0.136 0.31 -9999.0 0.0 -1.033 33.0 33.0 determination of left/right symmetry -0.093 0.204 -9999.0 0.0 -0.431 116.0 116.0 PIK3R1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.134 0.305 -9999.0 0.0 -1.015 33.0 33.0 IHH N/Hhip -0.291 0.332 -9999.0 0.0 -0.591 258.0 258.0 DHH N/Hhip -0.172 0.266 -9999.0 0.0 -0.507 190.0 190.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.093 0.204 -9999.0 0.0 -0.431 116.0 116.0 pancreas development -0.249 0.332 -9999.0 0.0 -0.671 189.0 189.0 HHAT 0.024 0.032 -9999.0 0.0 -0.674 1.0 1.0 PI3K 0.036 0.043 -9999.0 0.0 -0.509 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.1 0.263 -9999.0 0.0 -0.631 95.0 95.0 somite specification -0.093 0.204 -9999.0 0.0 -0.431 116.0 116.0 SHH Np/Cholesterol/PTCH1 -0.069 0.159 -9999.0 0.0 -0.338 105.0 105.0 SHH Np/Cholesterol/PTCH2 -0.043 0.149 -9999.0 0.0 -0.41 65.0 65.0 SHH Np/Cholesterol/Megalin -0.081 0.179 -9999.0 0.0 -0.381 126.0 126.0 SHH -0.005 0.029 -9999.0 0.0 -0.509 1.0 1.0 catabolic process -0.092 0.202 -9999.0 0.0 -0.404 140.0 140.0 SMO/Vitamin D3 -0.074 0.183 -9999.0 0.0 -0.383 107.0 107.0 SHH Np/Cholesterol/Hhip -0.139 0.201 -9999.0 0.0 -0.408 171.0 171.0 LRP2 -0.155 0.305 -9999.0 0.0 -0.662 131.0 131.0 receptor-mediated endocytosis -0.138 0.209 -9999.0 0.0 -0.59 43.0 43.0 SHH Np/Cholesterol/BOC 0.014 0.056 -9999.0 0.0 -0.373 9.0 9.0 SHH Np/Cholesterol/CDO -0.095 0.185 -9999.0 0.0 -0.376 145.0 145.0 mesenchymal cell differentiation 0.138 0.2 0.405 171.0 -9999.0 0.0 171.0 mol:Vitamin D3 -0.063 0.167 -9999.0 0.0 -0.355 70.0 70.0 IHH N/PTCH2 -0.167 0.286 -9999.0 0.0 -0.536 175.0 175.0 CDON -0.179 0.319 -9999.0 0.0 -0.672 146.0 146.0 IHH N/PTCH1 -0.09 0.207 -9999.0 0.0 -0.409 140.0 140.0 Megalin/LRPAP1 -0.102 0.238 -9999.0 0.0 -0.497 131.0 131.0 PTCH2 -0.084 0.255 -9999.0 0.0 -0.67 79.0 79.0 SHH Np/Cholesterol 0.009 0.023 -9999.0 0.0 -0.403 1.0 1.0 PTCH1 -0.093 0.203 -9999.0 0.0 -0.406 140.0 140.0 HHIP -0.249 0.332 -9999.0 0.0 -0.673 189.0 189.0