Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	247.0	1731.0	7.0	-0.421	-0.0	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	168.0	13123.0	78.0	-0.753	0.237	1000.0	-1000.0	-0.051	-1000.0
Reelin signaling pathway	136.0	7635.0	56.0	-0.462	0.061	1000.0	-1000.0	-0.037	-1000.0
Signaling events regulated by Ret tyrosine kinase	136.0	11193.0	82.0	-0.367	0.027	1000.0	-1000.0	-0.065	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	121.0	8258.0	68.0	-0.732	0.352	1000.0	-1000.0	-0.049	-1000.0
PDGFR-alpha signaling pathway	94.0	4171.0	44.0	-0.4	0.043	1000.0	-1000.0	-0.034	-1000.0
FOXA2 and FOXA3 transcription factor networks	88.0	4052.0	46.0	-0.843	0.031	1000.0	-1000.0	-0.063	-1000.0
Nongenotropic Androgen signaling	86.0	4516.0	52.0	-0.262	0.19	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by the Hedgehog family	83.0	4329.0	52.0	-0.291	0.138	1000.0	-1000.0	-0.039	-1000.0
Noncanonical Wnt signaling pathway	81.0	2118.0	26.0	-0.326	0.027	1000.0	-1000.0	-0.048	-1000.0
Wnt signaling	77.0	542.0	7.0	-0.326	0.014	1000.0	-1000.0	-0.025	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	68.0	3677.0	54.0	-0.462	0.039	1000.0	-1000.0	-0.066	-1000.0
Calcium signaling in the CD4+ TCR pathway	68.0	2119.0	31.0	-0.355	0.027	1000.0	-1000.0	-0.049	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	67.0	2311.0	34.0	-0.103	0.027	1000.0	-1000.0	-0.038	-1000.0
IL4-mediated signaling events	65.0	5919.0	91.0	-1.182	0.574	1000.0	-1000.0	-0.064	-1000.0
Glypican 1 network	63.0	3028.0	48.0	-0.299	0.052	1000.0	-1000.0	-0.025	-1000.0
Endothelins	63.0	6054.0	96.0	-0.316	0.029	1000.0	-1000.0	-0.052	-1000.0
IGF1 pathway	60.0	3456.0	57.0	-0.14	0.063	1000.0	-1000.0	-0.057	-1000.0
Ephrin B reverse signaling	54.0	2592.0	48.0	-0.237	0.117	1000.0	-1000.0	-0.029	-1000.0
HIF-1-alpha transcription factor network	53.0	4063.0	76.0	-0.487	0.041	1000.0	-1000.0	-0.068	-1000.0
Coregulation of Androgen receptor activity	51.0	3896.0	76.0	-0.678	0.076	1000.0	-1000.0	-0.024	-1000.0
BMP receptor signaling	50.0	4056.0	81.0	-0.445	0.052	1000.0	-1000.0	-0.063	-1000.0
TCR signaling in naïve CD8+ T cells	49.0	4564.0	93.0	-0.155	0.046	1000.0	-1000.0	-0.049	-1000.0
IL23-mediated signaling events	49.0	2994.0	60.0	-0.265	0.027	1000.0	-1000.0	-0.053	-1000.0
EPHB forward signaling	48.0	4099.0	85.0	-0.236	0.111	1000.0	-1000.0	-0.066	-1000.0
Arf6 signaling events	44.0	2753.0	62.0	-0.257	0.062	1000.0	-1000.0	-0.039	-1000.0
Glucocorticoid receptor regulatory network	44.0	5063.0	114.0	-0.449	0.257	1000.0	-1000.0	-0.055	-1000.0
IL12-mediated signaling events	40.0	3498.0	87.0	-0.358	0.029	1000.0	-1000.0	-0.069	-1000.0
Signaling mediated by p38-alpha and p38-beta	40.0	1789.0	44.0	-0.225	0.027	1000.0	-1000.0	-0.023	-1000.0
Thromboxane A2 receptor signaling	36.0	3825.0	105.0	-0.163	0.047	1000.0	-1000.0	-0.045	-1000.0
Hedgehog signaling events mediated by Gli proteins	36.0	2377.0	65.0	-0.582	0.064	1000.0	-1000.0	-0.037	-1000.0
EGFR-dependent Endothelin signaling events	31.0	669.0	21.0	-0.075	0.038	1000.0	-1000.0	-0.048	-1000.0
IL6-mediated signaling events	30.0	2292.0	75.0	-0.149	0.054	1000.0	-1000.0	-0.043	-1000.0
Plasma membrane estrogen receptor signaling	26.0	2240.0	86.0	-0.135	0.049	1000.0	-1000.0	-0.06	-1000.0
Ras signaling in the CD4+ TCR pathway	26.0	452.0	17.0	-0.105	0.041	1000.0	-1000.0	-0.028	-1000.0
ErbB2/ErbB3 signaling events	25.0	1628.0	65.0	-0.166	0.037	1000.0	-1000.0	-0.062	-1000.0
Syndecan-1-mediated signaling events	25.0	852.0	34.0	-0.079	0.027	1000.0	-1000.0	-0.034	-1000.0
Osteopontin-mediated events	25.0	975.0	38.0	-0.149	0.043	1000.0	-1000.0	-0.04	-1000.0
IFN-gamma pathway	25.0	1762.0	68.0	-0.17	0.035	1000.0	-1000.0	-0.047	-1000.0
Regulation of p38-alpha and p38-beta	25.0	1396.0	54.0	-0.359	0.065	1000.0	-1000.0	-0.051	-1000.0
FAS signaling pathway (CD95)	24.0	1172.0	47.0	-0.196	0.042	1000.0	-1000.0	-0.035	-1000.0
Regulation of Androgen receptor activity	24.0	1748.0	70.0	-0.448	0.036	1000.0	-1000.0	-0.058	-1000.0
BCR signaling pathway	23.0	2337.0	99.0	-0.103	0.048	1000.0	-1000.0	-0.059	-1000.0
Syndecan-4-mediated signaling events	23.0	1545.0	67.0	-0.156	0.039	1000.0	-1000.0	-0.036	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	22.0	1879.0	85.0	-0.218	0.135	1000.0	-1000.0	-0.043	-1000.0
Ceramide signaling pathway	20.0	1559.0	76.0	-0.15	0.075	1000.0	-1000.0	-0.036	-1000.0
LPA receptor mediated events	20.0	2078.0	102.0	-0.153	0.035	1000.0	-1000.0	-0.062	-1000.0
Fc-epsilon receptor I signaling in mast cells	19.0	1924.0	97.0	-0.149	0.044	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by PRL	19.0	660.0	34.0	-0.087	0.04	1000.0	-1000.0	-0.039	-1000.0
Angiopoietin receptor Tie2-mediated signaling	18.0	1647.0	88.0	-0.255	0.039	1000.0	-1000.0	-0.066	-1000.0
ceramide signaling pathway	17.0	842.0	49.0	-0.055	0.039	1000.0	-1000.0	-0.04	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	17.0	887.0	52.0	-0.179	0.057	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by PTP1B	16.0	1219.0	76.0	-0.19	0.039	1000.0	-1000.0	-0.034	-1000.0
Integrins in angiogenesis	16.0	1420.0	84.0	-0.141	0.056	1000.0	-1000.0	-0.049	-1000.0
IL27-mediated signaling events	16.0	862.0	51.0	-0.106	0.045	1000.0	-1000.0	-0.047	-1000.0
JNK signaling in the CD4+ TCR pathway	15.0	269.0	17.0	-0.084	0.026	1000.0	-1000.0	-0.031	-1000.0
amb2 Integrin signaling	15.0	1284.0	82.0	-0.186	0.035	1000.0	-1000.0	-0.042	-1000.0
LPA4-mediated signaling events	14.0	175.0	12.0	-0.054	0.004	1000.0	-1000.0	-0.028	-1000.0
Visual signal transduction: Cones	14.0	551.0	38.0	-0.043	0.043	1000.0	-1000.0	-0.016	-1000.0
p75(NTR)-mediated signaling	14.0	1848.0	125.0	-0.281	0.071	1000.0	-1000.0	-0.061	-1000.0
mTOR signaling pathway	14.0	793.0	53.0	-0.042	0.03	1000.0	-1000.0	-0.041	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	14.0	659.0	45.0	-0.056	0.076	1000.0	-1000.0	-0.042	-1000.0
Insulin Pathway	14.0	1080.0	74.0	-0.054	0.065	1000.0	-1000.0	-0.045	-1000.0
VEGFR1 specific signals	14.0	825.0	56.0	-0.045	0.058	1000.0	-1000.0	-0.053	-1000.0
Regulation of nuclear SMAD2/3 signaling	13.0	1874.0	136.0	-0.261	0.053	1000.0	-1000.0	-0.043	-1000.0
Nectin adhesion pathway	13.0	876.0	63.0	-0.109	0.073	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by HDAC Class III	13.0	554.0	40.0	-0.283	0.047	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	13.0	862.0	62.0	-0.077	0.062	1000.0	-1000.0	-0.044	-1000.0
Rapid glucocorticoid signaling	13.0	262.0	20.0	-0.061	0.034	1000.0	-1000.0	-0.006	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	13.0	1650.0	120.0	-0.241	0.074	1000.0	-1000.0	-0.049	-1000.0
Caspase cascade in apoptosis	12.0	952.0	74.0	-0.056	0.046	1000.0	-1000.0	-0.035	-1000.0
Cellular roles of Anthrax toxin	12.0	469.0	39.0	-0.056	0.027	1000.0	-1000.0	-0.02	-1000.0
Presenilin action in Notch and Wnt signaling	12.0	759.0	61.0	-0.149	0.07	1000.0	-1000.0	-0.054	-1000.0
IL2 signaling events mediated by PI3K	12.0	725.0	58.0	-0.059	0.048	1000.0	-1000.0	-0.042	-1000.0
FOXM1 transcription factor network	12.0	662.0	51.0	-0.221	0.051	1000.0	-1000.0	-0.087	-1000.0
Syndecan-3-mediated signaling events	11.0	397.0	35.0	-0.114	0.07	1000.0	-1000.0	-0.03	-1000.0
Visual signal transduction: Rods	11.0	601.0	52.0	-0.073	0.045	1000.0	-1000.0	-0.027	-1000.0
ErbB4 signaling events	10.0	744.0	69.0	-0.052	0.037	1000.0	-1000.0	-0.043	-1000.0
BARD1 signaling events	10.0	576.0	57.0	-0.04	0.051	1000.0	-1000.0	-0.052	-1000.0
Syndecan-2-mediated signaling events	10.0	721.0	69.0	-0.156	0.05	1000.0	-1000.0	-0.036	-1000.0
S1P1 pathway	10.0	378.0	36.0	-0.054	0.027	1000.0	-1000.0	-0.037	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	10.0	750.0	74.0	-0.127	0.068	1000.0	-1000.0	-0.067	-1000.0
TCGA08_p53	9.0	67.0	7.0	-0.025	0.025	1000.0	-1000.0	-0.013	-1000.0
Retinoic acid receptors-mediated signaling	9.0	533.0	58.0	-0.037	0.054	1000.0	-1000.0	-0.035	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	8.0	690.0	83.0	-0.172	0.049	1000.0	-1000.0	-0.03	-1000.0
TCGA08_rtk_signaling	8.0	225.0	26.0	-0.183	0.045	1000.0	-1000.0	-0.008	-1000.0
Regulation of Telomerase	8.0	863.0	102.0	-0.189	0.071	1000.0	-1000.0	-0.05	-1000.0
S1P3 pathway	8.0	365.0	42.0	-0.135	0.048	1000.0	-1000.0	-0.04	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	204.0	28.0	-0.135	0.056	1000.0	-1000.0	-0.023	-1000.0
Class I PI3K signaling events	7.0	582.0	73.0	-0.19	0.05	1000.0	-1000.0	-0.046	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	7.0	249.0	33.0	-0.11	0.055	1000.0	-1000.0	-0.031	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.015	0.015	1000.0	-1000.0	-0.003	-1000.0
a4b1 and a4b7 Integrin signaling	6.0	32.0	5.0	0.004	0.034	1000.0	-1000.0	-0.006	-1000.0
PLK1 signaling events	6.0	554.0	85.0	-0.006	0.049	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by STAT5	6.0	135.0	22.0	-0.033	0.033	1000.0	-1000.0	-0.034	-1000.0
TCGA08_retinoblastoma	6.0	54.0	8.0	-0.035	0.031	1000.0	-1000.0	-0.001	-1000.0
Insulin-mediated glucose transport	5.0	161.0	32.0	-0.085	0.05	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	627.0	125.0	-0.008	0.07	1000.0	-1000.0	-0.052	-1000.0
PDGFR-beta signaling pathway	5.0	501.0	97.0	-0.146	0.079	1000.0	-1000.0	-0.052	-1000.0
S1P4 pathway	5.0	140.0	25.0	-0.003	0.047	1000.0	-1000.0	-0.03	-1000.0
Aurora B signaling	5.0	368.0	67.0	-0.323	0.101	1000.0	-1000.0	-0.039	-1000.0
Circadian rhythm pathway	4.0	98.0	22.0	-0.017	0.04	1000.0	-1000.0	-0.023	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	304.0	68.0	-0.085	0.05	1000.0	-1000.0	-0.037	-1000.0
S1P5 pathway	4.0	72.0	17.0	-0.007	0.032	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class I	4.0	510.0	104.0	-0.056	0.063	1000.0	-1000.0	-0.034	-1000.0
Atypical NF-kappaB pathway	4.0	126.0	31.0	-0.018	0.04	1000.0	-1000.0	-0.023	-1000.0
Canonical Wnt signaling pathway	4.0	219.0	51.0	-0.037	0.065	1000.0	-1000.0	-0.049	-1000.0
Effects of Botulinum toxin	4.0	127.0	26.0	-0.067	0.048	1000.0	-1000.0	-0.01	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	71.0	23.0	-0.016	0.049	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	3.0	149.0	39.0	-0.056	0.062	1000.0	-1000.0	-0.038	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	137.0	37.0	-0.0	0.063	1000.0	-1000.0	-0.035	-1000.0
FoxO family signaling	3.0	246.0	64.0	-0.085	0.104	1000.0	-1000.0	-0.051	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	53.0	15.0	-0.005	0.027	1000.0	-1000.0	-0.03	-1000.0
E-cadherin signaling in keratinocytes	3.0	146.0	43.0	-0.03	0.051	1000.0	-1000.0	-0.039	-1000.0
p38 MAPK signaling pathway	3.0	170.0	44.0	-0.032	0.049	1000.0	-1000.0	-0.025	-1000.0
Aurora A signaling	2.0	128.0	60.0	-0.025	0.055	1000.0	-1000.0	-0.022	-1000.0
EPO signaling pathway	2.0	158.0	55.0	-0.015	0.059	1000.0	-1000.0	-0.051	-1000.0
TRAIL signaling pathway	2.0	109.0	48.0	-0.014	0.074	1000.0	-1000.0	-0.045	-1000.0
HIF-2-alpha transcription factor network	2.0	126.0	43.0	-0.16	0.164	1000.0	-1000.0	-0.042	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	96.0	36.0	-0.053	0.055	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	156.0	76.0	-0.059	0.066	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by HDAC Class II	1.0	89.0	75.0	-0.036	0.074	1000.0	-1000.0	-0.027	-1000.0
Arf6 trafficking events	1.0	104.0	71.0	-0.048	0.05	1000.0	-1000.0	-0.024	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.016	0.027	1000.0	-1000.0	-0.015	-1000.0
Arf6 downstream pathway	0.0	9.0	43.0	-0.061	0.045	1000.0	-1000.0	-0.031	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.007	0.046	1000.0	-1000.0	-0.014	-1000.0
Glypican 2 network	0.0	3.0	4.0	-0.02	0.016	1000.0	-1000.0	0.003	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	13.0	27.0	-0.0	0.067	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.026	0.052	1000.0	-1000.0	0.003	-1000.0
Arf1 pathway	0.0	21.0	54.0	-0.001	0.052	1000.0	-1000.0	-0.018	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.073	1000.0	-1000.0	-0.002	-1000.0
Total	3425	198957	7203	-22.3782227819	8.07504148052	131000	-131000	-5.04384923576	-131000