Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.188 0.286 -9999.0 0.0 -0.553 43.0 43.0 IHH -0.023 0.085 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 0.017 0.044 -9999.0 0.0 -0.294 2.0 2.0 LRPAP1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.017 0.043 0.292 2.0 -9999.0 0.0 2.0 SMO/beta Arrestin2 -0.082 0.174 -9999.0 0.0 -0.41 5.0 5.0 SMO -0.094 0.174 -9999.0 0.0 -0.428 5.0 5.0 AKT1 -0.022 0.105 -9999.0 0.0 -0.491 2.0 2.0 ARRB2 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.014 0.098 -9999.0 0.0 -0.513 4.0 4.0 ADRBK1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.093 0.172 -9999.0 0.0 -0.422 5.0 5.0 STIL -0.067 0.145 0.278 1.0 -0.342 2.0 3.0 DHH N/PTCH2 0.02 0.1 -9999.0 0.0 -0.374 7.0 7.0 DHH N/PTCH1 -0.089 0.187 -9999.0 0.0 -0.308 46.0 46.0 PIK3CA 0.027 0.05 -9999.0 0.0 -0.513 1.0 1.0 DHH 0.013 0.098 -9999.0 0.0 -0.513 4.0 4.0 PTHLH -0.349 0.479 -9999.0 0.0 -0.931 47.0 47.0 determination of left/right symmetry -0.093 0.172 -9999.0 0.0 -0.422 5.0 5.0 PIK3R1 0.023 0.07 -9999.0 0.0 -0.513 2.0 2.0 skeletal system development -0.344 0.472 -9999.0 0.0 -0.918 47.0 47.0 IHH N/Hhip -0.072 0.17 -9999.0 0.0 -0.419 21.0 21.0 DHH N/Hhip -0.042 0.176 -9999.0 0.0 -0.386 24.0 24.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.093 0.172 -9999.0 0.0 -0.422 5.0 5.0 pancreas development -0.064 0.208 -9999.0 0.0 -0.512 21.0 21.0 HHAT 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.077 -9999.0 0.0 -0.523 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.018 0.086 -9999.0 0.0 -0.513 3.0 3.0 somite specification -0.093 0.172 -9999.0 0.0 -0.422 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.077 0.139 -9999.0 0.0 -0.253 42.0 42.0 SHH Np/Cholesterol/PTCH2 0.015 0.051 -9999.0 0.0 -0.294 3.0 3.0 SHH Np/Cholesterol/Megalin 0.015 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.011 0.005 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.101 0.184 -9999.0 0.0 -0.325 46.0 46.0 SMO/Vitamin D3 -0.079 0.162 -9999.0 0.0 -0.279 43.0 43.0 SHH Np/Cholesterol/Hhip -0.017 0.104 -9999.0 0.0 -0.292 14.0 14.0 LRP2 0.018 0.002 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.081 0.156 -9999.0 0.0 -0.319 5.0 5.0 SHH Np/Cholesterol/BOC 0.012 0.058 -9999.0 0.0 -0.294 4.0 4.0 SHH Np/Cholesterol/CDO 0.024 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.017 0.103 0.291 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 -0.057 0.169 0.378 4.0 -0.254 42.0 46.0 IHH N/PTCH2 -0.006 0.087 -9999.0 0.0 -0.411 3.0 3.0 CDON 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.097 0.188 -9999.0 0.0 -0.327 46.0 46.0 Megalin/LRPAP1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.018 0.086 -9999.0 0.0 -0.513 3.0 3.0 SHH Np/Cholesterol 0.014 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.101 0.184 -9999.0 0.0 -0.326 46.0 46.0 HHIP -0.064 0.208 -9999.0 0.0 -0.513 21.0 21.0