Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Angiopoietin receptor Tie2-mediated signaling	36.0	3183.0	88.0	-0.548	0.114	1000.0	-1000.0	-0.06	-1000.0
Signaling mediated by p38-alpha and p38-beta	33.0	1494.0	44.0	-0.358	0.032	1000.0	-1000.0	-0.017	-1000.0
Class IB PI3K non-lipid kinase events	33.0	99.0	3.0	-0.119	-1000.0	1000.0	-1000.0	-0.02	-1000.0
Nongenotropic Androgen signaling	32.0	1679.0	52.0	-0.442	0.278	1000.0	-1000.0	-0.02	-1000.0
Endothelins	28.0	2716.0	96.0	-0.585	0.059	1000.0	-1000.0	-0.027	-1000.0
PDGFR-alpha signaling pathway	26.0	1186.0	44.0	-0.566	0.058	1000.0	-1000.0	-0.018	-1000.0
IL4-mediated signaling events	23.0	2181.0	91.0	-0.884	0.577	1000.0	-1000.0	-0.04	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	22.0	775.0	34.0	-0.127	0.033	1000.0	-1000.0	-0.018	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	22.0	1512.0	68.0	-0.5	0.109	1000.0	-1000.0	-0.045	-1000.0
Reelin signaling pathway	21.0	1226.0	56.0	-0.195	0.062	1000.0	-1000.0	-0.018	-1000.0
Calcium signaling in the CD4+ TCR pathway	21.0	670.0	31.0	-0.362	0.032	1000.0	-1000.0	-0.033	-1000.0
HIF-1-alpha transcription factor network	20.0	1578.0	76.0	-0.3	0.048	1000.0	-1000.0	-0.025	-1000.0
Thromboxane A2 receptor signaling	19.0	2084.0	105.0	-0.264	0.076	1000.0	-1000.0	-0.032	-1000.0
Signaling events regulated by Ret tyrosine kinase	19.0	1615.0	82.0	-0.266	0.051	1000.0	-1000.0	-0.043	-1000.0
IL6-mediated signaling events	17.0	1323.0	75.0	-0.244	0.055	1000.0	-1000.0	-0.03	-1000.0
Osteopontin-mediated events	16.0	641.0	38.0	-0.244	0.035	1000.0	-1000.0	-0.019	-1000.0
IL23-mediated signaling events	16.0	967.0	60.0	-0.56	0.065	1000.0	-1000.0	-0.042	-1000.0
TCGA08_retinoblastoma	14.0	114.0	8.0	-0.029	0.029	1000.0	-1000.0	-0.002	-1000.0
FOXM1 transcription factor network	14.0	754.0	51.0	-0.546	0.033	1000.0	-1000.0	-0.017	-1000.0
Coregulation of Androgen receptor activity	13.0	1011.0	76.0	-0.301	0.059	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by the Hedgehog family	12.0	647.0	52.0	-0.349	0.037	1000.0	-1000.0	-0.018	-1000.0
Glucocorticoid receptor regulatory network	12.0	1389.0	114.0	-0.512	0.189	1000.0	-1000.0	-0.036	-1000.0
S1P1 pathway	12.0	449.0	36.0	-0.356	0.031	1000.0	-1000.0	-0.023	-1000.0
Ras signaling in the CD4+ TCR pathway	12.0	217.0	17.0	-0.187	0.043	1000.0	-1000.0	-0.007	-1000.0
IL12-mediated signaling events	11.0	960.0	87.0	-0.603	0.082	1000.0	-1000.0	-0.044	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1064.0	93.0	-0.126	0.046	1000.0	-1000.0	-0.035	-1000.0
ErbB2/ErbB3 signaling events	10.0	670.0	65.0	-0.233	0.045	1000.0	-1000.0	-0.04	-1000.0
Fc-epsilon receptor I signaling in mast cells	10.0	991.0	97.0	-0.244	0.034	1000.0	-1000.0	-0.049	-1000.0
amb2 Integrin signaling	10.0	886.0	82.0	-0.284	0.04	1000.0	-1000.0	-0.025	-1000.0
Integrins in angiogenesis	10.0	877.0	84.0	-0.104	0.055	1000.0	-1000.0	-0.032	-1000.0
Wnt signaling	10.0	76.0	7.0	-0.128	0.022	1000.0	-1000.0	-0.004	-1000.0
PDGFR-beta signaling pathway	10.0	1035.0	97.0	-0.099	0.039	1000.0	-1000.0	-0.034	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	9.0	525.0	54.0	-0.195	0.047	1000.0	-1000.0	-0.019	-1000.0
Noncanonical Wnt signaling pathway	9.0	246.0	26.0	-0.138	0.032	1000.0	-1000.0	-0.024	-1000.0
Arf6 signaling events	9.0	558.0	62.0	-0.226	0.064	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by PTP1B	9.0	705.0	76.0	-0.207	0.049	1000.0	-1000.0	-0.029	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	9.0	512.0	52.0	-0.159	0.068	1000.0	-1000.0	-0.028	-1000.0
Retinoic acid receptors-mediated signaling	9.0	534.0	58.0	-0.144	0.063	1000.0	-1000.0	-0.019	-1000.0
BARD1 signaling events	8.0	502.0	57.0	-0.068	0.06	1000.0	-1000.0	-0.028	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	147.0	17.0	-0.116	0.032	1000.0	-1000.0	-0.016	-1000.0
BMP receptor signaling	8.0	675.0	81.0	-0.207	0.063	1000.0	-1000.0	-0.034	-1000.0
Glypican 1 network	8.0	385.0	48.0	-0.134	0.057	1000.0	-1000.0	-0.014	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	995.0	120.0	-0.381	0.175	1000.0	-1000.0	-0.038	-1000.0
Regulation of Androgen receptor activity	8.0	567.0	70.0	-0.17	0.044	1000.0	-1000.0	-0.04	-1000.0
FAS signaling pathway (CD95)	7.0	346.0	47.0	-0.44	0.048	1000.0	-1000.0	-0.038	-1000.0
BCR signaling pathway	7.0	722.0	99.0	-0.158	0.06	1000.0	-1000.0	-0.056	-1000.0
FOXA2 and FOXA3 transcription factor networks	6.0	312.0	46.0	-0.665	0.036	1000.0	-1000.0	-0.023	-1000.0
Nectin adhesion pathway	6.0	389.0	63.0	-0.075	0.08	1000.0	-1000.0	-0.024	-1000.0
LPA receptor mediated events	6.0	692.0	102.0	-0.244	0.033	1000.0	-1000.0	-0.062	-1000.0
Syndecan-4-mediated signaling events	6.0	423.0	67.0	-0.191	0.046	1000.0	-1000.0	-0.028	-1000.0
Insulin Pathway	6.0	512.0	74.0	-0.326	0.075	1000.0	-1000.0	-0.033	-1000.0
Aurora B signaling	6.0	443.0	67.0	-0.454	0.072	1000.0	-1000.0	-0.031	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	815.0	136.0	-0.291	0.073	1000.0	-1000.0	-0.026	-1000.0
Syndecan-2-mediated signaling events	5.0	412.0	69.0	-0.191	0.046	1000.0	-1000.0	-0.026	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	29.0	5.0	-0.008	0.023	1000.0	-1000.0	0.015	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	440.0	85.0	-0.398	0.063	1000.0	-1000.0	-0.035	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	358.0	61.0	-0.244	0.082	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by PI3K	5.0	296.0	58.0	-0.186	0.05	1000.0	-1000.0	-0.024	-1000.0
LPA4-mediated signaling events	4.0	59.0	12.0	-0.118	0.009	1000.0	-1000.0	-0.019	-1000.0
p75(NTR)-mediated signaling	4.0	502.0	125.0	-0.131	0.082	1000.0	-1000.0	-0.042	-1000.0
Plasma membrane estrogen receptor signaling	4.0	385.0	86.0	-0.062	0.059	1000.0	-1000.0	-0.04	-1000.0
Syndecan-1-mediated signaling events	3.0	123.0	34.0	-0.131	0.032	1000.0	-1000.0	-0.019	-1000.0
PLK1 signaling events	3.0	256.0	85.0	-0.034	0.053	1000.0	-1000.0	-0.029	-1000.0
Ceramide signaling pathway	3.0	235.0	76.0	-0.062	0.09	1000.0	-1000.0	-0.025	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	116.0	37.0	-0.025	0.052	1000.0	-1000.0	-0.017	-1000.0
IL1-mediated signaling events	3.0	202.0	62.0	-0.053	0.077	1000.0	-1000.0	-0.026	-1000.0
HIF-2-alpha transcription factor network	3.0	152.0	43.0	-0.099	0.101	1000.0	-1000.0	-0.054	-1000.0
Ephrin B reverse signaling	3.0	174.0	48.0	-0.075	0.052	1000.0	-1000.0	-0.023	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	109.0	36.0	-0.043	0.054	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	147.0	45.0	-0.036	0.083	1000.0	-1000.0	-0.028	-1000.0
Glypican 2 network	3.0	12.0	4.0	0.013	0.023	1000.0	-1000.0	0.018	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	410.0	125.0	-0.075	0.063	1000.0	-1000.0	-0.027	-1000.0
IL27-mediated signaling events	3.0	181.0	51.0	-0.194	0.064	1000.0	-1000.0	-0.043	-1000.0
TCGA08_rtk_signaling	3.0	92.0	26.0	-0.16	0.044	1000.0	-1000.0	-0.012	-1000.0
IL2 signaling events mediated by STAT5	3.0	77.0	22.0	-0.053	0.036	1000.0	-1000.0	-0.02	-1000.0
IGF1 pathway	3.0	198.0	57.0	-0.021	0.068	1000.0	-1000.0	-0.023	-1000.0
Caspase cascade in apoptosis	2.0	151.0	74.0	-0.074	0.079	1000.0	-1000.0	-0.033	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	52.0	23.0	-0.059	0.062	1000.0	-1000.0	-0.018	-1000.0
ErbB4 signaling events	2.0	190.0	69.0	-0.108	0.061	1000.0	-1000.0	-0.023	-1000.0
Cellular roles of Anthrax toxin	2.0	100.0	39.0	-0.102	0.044	1000.0	-1000.0	-0.017	-1000.0
Aurora C signaling	2.0	16.0	7.0	-0.006	0.028	1000.0	-1000.0	-0.007	-1000.0
mTOR signaling pathway	2.0	150.0	53.0	-0.023	0.043	1000.0	-1000.0	-0.029	-1000.0
ceramide signaling pathway	2.0	145.0	49.0	-0.017	0.047	1000.0	-1000.0	-0.033	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	217.0	83.0	-0.097	0.063	1000.0	-1000.0	-0.013	-1000.0
Atypical NF-kappaB pathway	2.0	70.0	31.0	-0.008	0.036	1000.0	-1000.0	-0.012	-1000.0
Canonical Wnt signaling pathway	2.0	147.0	51.0	-0.071	0.075	1000.0	-1000.0	-0.032	-1000.0
EPHB forward signaling	2.0	197.0	85.0	-0.135	0.076	1000.0	-1000.0	-0.048	-1000.0
Regulation of p38-alpha and p38-beta	2.0	156.0	54.0	-0.049	0.075	1000.0	-1000.0	-0.04	-1000.0
Class I PI3K signaling events	2.0	174.0	73.0	-0.055	0.059	1000.0	-1000.0	-0.026	-1000.0
Regulation of Telomerase	2.0	224.0	102.0	-0.244	0.08	1000.0	-1000.0	-0.026	-1000.0
S1P3 pathway	2.0	112.0	42.0	-0.041	0.048	1000.0	-1000.0	-0.02	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	77.0	33.0	-0.038	0.078	1000.0	-1000.0	-0.027	-1000.0
Rapid glucocorticoid signaling	2.0	47.0	20.0	-0.011	0.034	1000.0	-1000.0	-0.002	-1000.0
Visual signal transduction: Rods	2.0	142.0	52.0	-0.17	0.078	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by PRL	2.0	100.0	34.0	-0.089	0.047	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	230.0	78.0	-0.029	0.065	1000.0	-1000.0	-0.03	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	42.0	28.0	-0.0	0.065	1000.0	-1000.0	-0.013	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	117.0	65.0	-0.012	0.077	1000.0	-1000.0	-0.027	-1000.0
Aurora A signaling	1.0	77.0	60.0	-0.016	0.073	1000.0	-1000.0	-0.012	-1000.0
EPO signaling pathway	1.0	80.0	55.0	0.005	0.087	1000.0	-1000.0	-0.019	-1000.0
IFN-gamma pathway	1.0	103.0	68.0	-0.0	0.081	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class III	1.0	55.0	40.0	-0.051	0.052	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class I	1.0	120.0	104.0	-0.056	0.078	1000.0	-1000.0	-0.03	-1000.0
FoxO family signaling	1.0	99.0	64.0	-0.034	0.085	1000.0	-1000.0	-0.024	-1000.0
Effects of Botulinum toxin	1.0	39.0	26.0	-0.016	0.05	1000.0	-1000.0	-0.001	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	82.0	74.0	-0.061	0.071	1000.0	-1000.0	-0.047	-1000.0
Arf6 trafficking events	1.0	71.0	71.0	-0.055	0.058	1000.0	-1000.0	-0.027	-1000.0
VEGFR1 specific signals	1.0	63.0	56.0	-0.008	0.072	1000.0	-1000.0	-0.031	-1000.0
E-cadherin signaling in keratinocytes	1.0	54.0	43.0	-0.025	0.056	1000.0	-1000.0	-0.021	-1000.0
S1P4 pathway	1.0	45.0	25.0	-0.0	0.049	1000.0	-1000.0	-0.012	-1000.0
Canonical NF-kappaB pathway	0.0	32.0	39.0	-0.016	0.073	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class II	0.0	60.0	75.0	-0.046	0.088	1000.0	-1000.0	-0.019	-1000.0
PLK2 and PLK4 events	0.0	1.0	3.0	0.019	-1000.0	1000.0	-1000.0	-0.008	-1000.0
Visual signal transduction: Cones	0.0	5.0	38.0	-0.007	0.071	1000.0	-1000.0	-0.005	-1000.0
Circadian rhythm pathway	0.0	7.0	22.0	-0.012	0.068	1000.0	-1000.0	-0.022	-1000.0
Ephrin A  reverse signaling	0.0	2.0	7.0	-0.0	0.031	1000.0	-1000.0	-0.0	-1000.0
Arf6 downstream pathway	0.0	21.0	43.0	-0.056	0.058	1000.0	-1000.0	-0.018	-1000.0
Insulin-mediated glucose transport	0.0	14.0	32.0	-0.0	0.06	1000.0	-1000.0	-0.013	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	40.0	68.0	-0.046	0.062	1000.0	-1000.0	-0.017	-1000.0
TRAIL signaling pathway	0.0	33.0	48.0	-0.0	0.079	1000.0	-1000.0	-0.022	-1000.0
S1P5 pathway	0.0	9.0	17.0	-0.035	0.039	1000.0	-1000.0	-0.002	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.007	0.028	1000.0	-1000.0	-0.013	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	9.0	15.0	-0.007	0.032	1000.0	-1000.0	-0.025	-1000.0
Syndecan-3-mediated signaling events	0.0	27.0	35.0	-0.024	0.082	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	44.0	76.0	-0.005	0.079	1000.0	-1000.0	-0.046	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.0	0.079	1000.0	-1000.0	-0.022	-1000.0
EGFR-dependent Endothelin signaling events	0.0	12.0	21.0	-0.007	0.077	1000.0	-1000.0	-0.03	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.028	0.056	1000.0	-1000.0	0.014	-1000.0
p38 MAPK signaling pathway	0.0	27.0	44.0	-0.003	0.065	1000.0	-1000.0	-0.012	-1000.0
Arf1 pathway	0.0	17.0	54.0	-0.001	0.058	1000.0	-1000.0	-0.01	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.088	1000.0	-1000.0	-0.0	-1000.0
Total	868	56145	7203	-20.016569239	-1991.5444584	131000	-131000	-3.18616984958	-131000