rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(4), EIF4A1(5), EIF4A2(8), EIF4B(7), EIF4E(1), EIF4G1(16), EIF4G2(7), EIF4G3(23), FKBP1A(1), MKNK1(3), PDK2(4), PDPK1(3), PIK3CA(172), PIK3R1(99), PPP2CA(6), PTEN(227), RPS6(7), RPS6KB1(3), TSC1(12), TSC2(14) 9925342 622 218 409 44 89 126 123 38 202 44 <1.00e-15 <1.00e-15 <3.87e-14 2 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(4), APC(56), AXIN1(9), CCND1(14), CD14(2), CTNNB1(80), DVL1(3), FZD1(3), GJA1(5), GNAI1(5), GSK3B(13), IRAK1(4), LBP(3), LEF1(8), LY96(4), MYD88(2), NFKB1(10), PDPK1(3), PIK3CA(172), PIK3R1(99), PPP2CA(6), RELA(6), TIRAP(2), TLR4(17), TOLLIP(1), WNT1(1) 10634125 532 210 352 57 77 194 121 6 115 19 1.24e-13 <1.00e-15 <3.87e-14 3 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(4), AKT2(6), AKT3(11), BPNT1(3), GRB2(3), ILK(5), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(172), PIK3CD(12), PTEN(227), PTK2B(15), RBL2(19), SHC1(6), SOS1(13) 7243620 503 208 305 39 89 116 107 36 127 28 <1.00e-15 <1.00e-15 <3.87e-14 4 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(5), AGT(8), AKT1(4), CALM1(2), CALM2(3), CALR(3), CAMK1(3), CAMK1G(5), CAMK4(5), CREBBP(32), CSNK1A1(3), EDN1(4), ELSPBP1(5), F2(8), FKBP1A(1), GATA4(3), GSK3B(13), HAND1(6), HRAS(1), IGF1(5), LIF(3), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(11), MEF2C(10), MYH2(41), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NKX2-5(2), NPPA(2), PIK3CA(172), PIK3R1(99), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RAF1(9), RPS6KB1(3), SYT1(4) 18041266 568 206 439 96 127 166 134 5 116 20 3.96e-08 <1.00e-15 <3.87e-14 5 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(4), BAD(1), BCL2L1(4), CBL(12), CFLAR(2), CRKL(6), E2F1(9), FOS(3), GRB2(3), HRAS(1), IL2RA(4), IL2RB(3), IL2RG(11), IRS1(13), JAK1(20), JAK3(10), MAPK1(2), MAPK3(3), MYC(8), NMI(3), PIK3CA(172), PIK3R1(99), PPIA(1), PTPN6(5), RAF1(9), RPS6KB1(3), SHC1(6), SOS1(13), STAT5A(5), STAT5B(7), SYK(4) 12777577 446 203 323 55 81 126 119 5 100 15 8.83e-10 <1.00e-15 <3.87e-14 6 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), INS(1), INSR(18), IRS1(13), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(11), PIK3CA(172), PIK3R1(99), PTPN11(8), RAF1(9), RASA1(29), SHC1(6), SLC2A4(9), SOS1(13), SRF(3) 9128952 416 202 289 36 79 113 106 5 97 16 4.30e-14 <1.00e-15 <3.87e-14 7 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(21), AKT1(4), ASAH1(6), GNAI1(5), GNB1(2), GNGT1(1), ITGAV(10), ITGB3(11), MAPK1(2), MAPK3(3), PDGFA(3), PDGFRA(24), PIK3CA(172), PIK3R1(99), PLCB1(5), PRKCA(11), PTK2(12), RAC1(1), SMPD1(4), SMPD2(6), SPHK1(2), SRC(3) 9845923 407 201 287 58 68 105 113 6 98 17 1.81e-06 <1.00e-15 <3.87e-14 8 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(21), AKT1(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CREB1(5), GNAS(24), GRB2(3), HRAS(1), MAPK1(2), MAPK14(4), MAPK3(3), PIK3CA(172), PIK3R1(99), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), RAC1(1), RPS6KA1(1), RPS6KA5(11), SOS1(13) 10330216 425 200 300 50 88 106 110 5 100 16 3.43e-09 <1.00e-15 <3.87e-14 9 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(32), EP300(32), FYN(5), IL2RG(11), IL7(1), IL7R(12), JAK1(20), JAK3(10), LCK(4), NMI(3), PIK3CA(172), PIK3R1(99), PTK2B(15), STAT5A(5), STAT5B(7) 10213532 428 200 305 53 74 113 113 6 106 16 1.41e-08 <1.00e-15 <3.87e-14 10 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(4), BAD(1), CASP9(3), CHUK(8), GH1(2), GHR(8), NFKB1(10), NFKBIA(3), PDPK1(3), PIK3CA(172), PIK3R1(99), PPP2CA(6), RELA(6), YWHAH(3) 5135005 328 199 209 21 48 86 91 4 84 15 7.89e-12 <1.00e-15 <3.87e-14 11 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(4), BCR(6), CRKL(6), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(11), MYC(8), PIK3CA(172), PIK3R1(99), RAF1(9), SOS1(13), STAT1(15), STAT5A(5), STAT5B(7) 9960926 424 199 299 36 75 115 112 4 99 19 5.77e-14 <1.00e-15 <3.87e-14 12 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(12), CALM1(2), CALM2(3), ELK1(3), FCER1A(9), FCER1G(2), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP2K4(9), MAP2K7(4), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(11), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), PAK2(3), PIK3CA(172), PIK3R1(99), PLA2G4A(13), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), RAF1(9), SHC1(6), SOS1(13), SYK(4), SYT1(4), VAV1(12) 15285000 511 198 384 74 100 150 122 6 117 16 3.34e-08 <1.00e-15 <3.87e-14 13 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(4), DPM2(1), GRB2(3), HRAS(1), KLK2(2), NTRK1(13), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), SHC1(6), SOS1(13) 5625851 337 198 214 28 53 88 94 4 83 15 6.65e-10 <1.00e-15 <3.87e-14 14 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(4), BAD(1), BCL2L1(4), CASP9(3), CDC42(3), CHUK(8), ELK1(3), H2AFX(1), HRAS(1), MAP2K1(2), MAPK3(3), NFKB1(10), PIK3CA(172), PIK3R1(99), RAC1(1), RAF1(9), RALA(6), RALBP1(6), RALGDS(9), RELA(6), RHOA(3) 6942603 354 197 233 27 56 99 94 4 84 17 2.14e-12 <1.00e-15 <3.87e-14 15 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(1), IL18(2), ITGB1(8), KLRC1(7), KLRC2(1), KLRC3(2), KLRC4(5), KLRD1(3), MAP2K1(2), MAPK3(3), PAK1(3), PIK3CA(172), PIK3R1(99), PTK2B(15), PTPN6(5), RAC1(1), SYK(4), VAV1(12) 6852023 348 196 228 33 57 91 91 5 89 15 2.21e-09 <1.00e-15 <3.87e-14 16 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(4), AKT2(6), AKT3(11), BAD(1), GRB2(3), GSK3A(10), GSK3B(13), IL4R(6), IRS1(13), JAK1(20), JAK3(10), MAP4K1(12), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(99), PPP1R13B(9), RAF1(9), SHC1(6), SOS1(13), SOS2(17), STAT6(10) 12574116 463 202 336 53 103 116 118 5 105 16 2.71e-11 1.22e-15 3.87e-14 17 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 DUSP1(2), GORASP1(9), IKBKG(3), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4), MAPKAPK5(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), PIK3CA(172), PIK3CD(12), PIK3R1(99), SYT1(4), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(7) 11364262 428 197 308 59 89 111 101 4 108 15 2.66e-08 1.22e-15 3.87e-14 18 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(9), DPM2(1), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), KLK2(2), MAP2K1(2), MAPK3(3), MAPK8(11), NGFR(3), PIK3CA(172), PIK3R1(99), PLCG1(12), RAF1(9), SHC1(6), SOS1(13) 6810755 353 194 227 21 57 92 100 4 85 15 1.34e-14 1.22e-15 3.87e-14 19 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(21), AKT1(4), BAD(1), BAX(2), BCL2L1(4), CSF2RB(14), IGF1(5), IGF1R(13), IL3(2), IL3RA(9), KIT(23), KITLG(3), PIK3CA(172), PIK3R1(99), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), YWHAH(3) 7856210 402 200 282 53 73 110 106 6 91 16 9.92e-09 1.33e-15 3.87e-14 20 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF4E(1), GSK3B(13), IGF1(5), IGF1R(13), INPPL1(18), PDK2(4), PDPK1(3), PIK3CA(172), PIK3R1(99), PPP2CA(6), PTEN(227), RPS6(7), RPS6KB1(3) 7138255 597 217 382 44 78 118 113 40 206 42 <1.00e-15 1.44e-15 3.87e-14 21 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(4), CABIN1(19), CALM1(2), CALM2(3), CAMK1(3), CAMK1G(5), HDAC5(12), IGF1(5), IGF1R(13), INS(1), INSR(18), MAP2K6(10), MAPK14(4), MAPK7(14), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), NFATC1(10), NFATC2(13), PIK3CA(172), PIK3R1(99), PPP3CA(4), PPP3CB(6), PPP3CC(6), SYT1(4), YWHAH(3) 12178275 451 201 328 71 105 112 113 8 98 15 2.05e-07 1.44e-15 3.87e-14 22 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(4), CREB1(5), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(10), PIK3CA(172), PIK3R1(99), RB1(26), RELA(6), SP1(7) 7166136 392 200 270 30 61 104 106 4 98 19 1.13e-12 1.44e-15 3.87e-14 23 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(5), MAX(9), MYC(8), SP1(7), SP3(10), TP53(74), WT1(3) 2507279 116 91 87 10 35 30 27 2 22 0 2.87e-06 1.44e-15 3.87e-14 24 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(9), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAPK3(3), MPL(7), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), RAF1(9), RASA1(29), SHC1(6), SOS1(13), STAT1(15), STAT3(11), STAT5A(5), STAT5B(7), THPO(5) 10932923 440 197 311 48 82 119 115 4 101 19 7.49e-10 1.67e-15 4.27e-14 25 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(2), GHR(8), GRB2(3), HRAS(1), INS(1), INSR(18), IRS1(13), JAK2(17), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), PTPN6(5), RAF1(9), RPS6KA1(1), SHC1(6), SLC2A4(9), SOS1(13), SRF(3), STAT5A(5), STAT5B(7) 11855606 422 198 298 58 89 107 114 5 89 18 2.38e-07 1.89e-15 4.65e-14 26 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(5), EIF1(1), EIF2B2(5), EIF2B3(7), EIF2B4(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), ELAVL1(8), FLT1(20), FLT4(8), HIF1A(16), HRAS(1), KDR(26), NOS3(11), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), PTK2(12), PXN(6), SHC1(6), VHL(3) 12174092 455 198 332 55 93 119 108 7 113 15 3.21e-10 2.00e-15 4.73e-14 27 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(8), CDKN2A(1), E2F1(9), MDM2(5), MYC(8), PIK3CA(172), PIK3R1(99), POLR1A(15), POLR1B(16), POLR1C(2), POLR1D(3), RAC1(1), RB1(26), TBX2(2), TP53(74), TWIST1(1) 7080267 442 223 298 48 85 109 119 6 105 18 1.62e-10 2.44e-15 5.02e-14 28 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(4), AKT2(6), AKT3(11), BRD4(10), CAP1(4), CBL(12), CDC42(3), CDKN2A(1), F2RL2(2), FLOT1(1), FLOT2(2), GRB2(3), GSK3A(10), GSK3B(13), IGFBP1(4), INPPL1(18), IRS1(13), IRS4(20), LNPEP(10), MAPK1(2), MAPK3(3), PARD3(19), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(99), PTEN(227), PTPN1(5), RAF1(9), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KB1(3), SERPINB6(3), SHC1(6), SLC2A4(9), SORBS1(18), SOS1(13), SOS2(17), YWHAE(5), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1) 20615343 812 217 588 114 152 178 168 40 229 45 2.07e-12 2.44e-15 5.02e-14 29 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5(2), CDK5R1(3), CFL1(1), CHN1(2), LIMK1(8), MAP3K1(30), MYL2(2), MYLK(14), NCF2(8), PAK1(3), PDGFRA(24), PIK3CA(172), PIK3R1(99), PLD1(13), PPP1R12B(19), RAC1(1), RALBP1(6), RPS6KB1(3), TRIO(34), VAV1(12), WASF1(3) 12890193 460 200 335 67 88 126 113 6 108 19 4.41e-07 2.44e-15 5.02e-14 30 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(4), BAD(1), GRB2(3), HRAS(1), IGF1R(13), IRS1(13), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(172), PIK3R1(99), RAF1(9), SHC1(6), SOS1(13), YWHAH(3) 6731221 344 196 221 33 61 84 96 5 83 15 2.35e-09 2.44e-15 5.02e-14 31 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(4), AKT2(6), AKT3(11), CDKN1A(1), ELK1(3), GRB2(3), HRAS(1), MAP2K1(2), MAP2K2(5), NGFR(3), NTRK1(13), PIK3CA(172), PIK3CD(12), SHC1(6), SOS1(13) 5624797 255 151 154 31 58 92 82 3 20 0 2.26e-08 2.55e-15 5.04e-14 32 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(7), AKT1(4), ANXA1(4), CALM1(2), CALM2(3), GNAS(24), GNB1(2), GNGT1(1), NFKB1(10), NOS3(11), NPPA(2), NR3C1(17), PIK3CA(172), PIK3R1(99), RELA(6), SYT1(4) 6288912 368 197 245 25 79 91 90 4 89 15 6.48e-14 2.78e-15 5.04e-14 33 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(5), CRK(2), CRKL(6), DOCK1(21), ELK1(3), FOS(3), GAB1(7), GRB2(3), HGF(14), HRAS(1), ITGA1(17), ITGB1(8), JUN(1), MAP2K1(2), MAP2K2(5), MAP4K1(12), MAPK1(2), MAPK3(3), MAPK8(11), MET(17), PAK1(3), PIK3CA(172), PIK3R1(99), PTEN(227), PTK2(12), PTK2B(15), PTPN11(8), PXN(6), RAF1(9), RAP1A(4), RAP1B(2), RASA1(29), SOS1(13), SRC(3), STAT3(11) 16563754 756 217 536 89 129 178 144 37 224 44 <1.00e-15 2.89e-15 5.04e-14 34 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(4), CCND1(14), CCNE1(6), CDK2(2), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(7), E2F1(9), HRAS(1), MAPK1(2), MAPK3(3), NFKB1(10), NFKBIA(3), PAK1(3), PIK3CA(172), PIK3R1(99), RAC1(1), RAF1(9), RB1(26), RELA(6), TFDP1(13) 7293532 396 202 272 37 66 101 106 4 101 18 3.46e-11 2.89e-15 5.04e-14 35 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(4), CAT(4), GH1(2), GHR(8), HRAS(1), IGF1(5), IGF1R(13), PIK3CA(172), PIK3R1(99), SHC1(6), SOD1(2), SOD2(3) 4715937 319 195 200 28 51 77 90 5 81 15 2.89e-09 2.89e-15 5.04e-14 36 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IGF1(5), IGF1R(13), IRS1(13), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(11), PIK3CA(172), PIK3R1(99), PTPN11(8), RAF1(9), RASA1(29), SHC1(6), SOS1(13), SRF(3) 8874392 406 200 279 33 71 111 106 5 97 16 3.47e-14 3.00e-15 5.04e-14 37 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(4), BCAR1(8), CDKN1B(7), GRB2(3), ILK(5), ITGB1(8), MAPK1(2), MAPK3(3), PDK2(4), PDPK1(3), PIK3CA(172), PIK3R1(99), PTEN(227), PTK2(12), SHC1(6), SOS1(13) 6867110 576 213 361 29 70 112 123 37 192 42 <1.00e-15 3.11e-15 5.04e-14 38 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(4), PIK3CA(172), PIK3R1(99), PLCB1(5), PLCG1(12), PRKCA(11), VAV1(12) 4719996 315 195 195 36 51 68 90 7 84 15 1.53e-05 3.11e-15 5.04e-14 39 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(8), DNAJC3(8), EIF2S1(2), EIF2S2(9), NFKB1(10), NFKBIA(3), RELA(6), TP53(74) 3670290 120 82 93 8 31 37 24 2 26 0 9.02e-07 3.22e-15 5.09e-14 40 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(8), CRK(2), CXCL12(3), CXCR4(1), GNAI1(5), GNAQ(3), GNB1(2), GNGT1(1), HRAS(1), MAP2K1(2), MAPK1(2), MAPK3(3), NFKB1(10), PIK3C2G(16), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), PTK2(12), PTK2B(15), PXN(6), RAF1(9), RELA(6) 10130836 401 197 280 55 79 101 107 4 95 15 7.00e-07 3.55e-15 5.47e-14 41 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(4), BAD(1), CHRNB1(2), CHRNG(4), MUSK(14), PIK3CA(172), PIK3R1(99), PTK2(12), PTK2B(15), RAPSN(2), SRC(3), TERT(4), YWHAH(3) 5901003 335 196 216 43 56 85 93 4 82 15 4.08e-06 3.77e-15 5.67e-14 42 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(3), CD3D(6), CD3E(2), CD3G(3), CD80(5), CD86(5), CTLA4(2), GRB2(3), HLA-DRA(1), ICOS(3), IL2(2), ITK(7), LCK(4), PIK3CA(172), PIK3R1(99), PTPN11(8) 4602586 325 194 206 16 48 85 87 5 85 15 5.17e-14 4.11e-15 6.02e-14 43 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(3), AKT1(4), AKT2(6), AKT3(11), BAD(1), BTK(12), CDKN2A(1), DAPP1(9), GRB2(3), GSK3A(10), GSK3B(13), IARS(8), IGFBP1(4), INPP5D(9), PDK1(2), PIK3CA(172), PPP1R13B(9), PTEN(227), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KB1(3), SHC1(6), SOS1(13), SOS2(17), TEC(7), YWHAE(5), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1) 13065934 596 211 398 67 107 149 129 37 144 30 1.98e-14 4.22e-15 6.04e-14 44 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(4), EIF4A1(5), EIF4A2(8), EIF4E(1), EIF4G1(16), EIF4G2(7), EIF4G3(23), GHR(8), IRS1(13), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(3), PABPC1(10), PDK2(4), PDPK1(3), PIK3CA(172), PIK3R1(99), PRKCA(11), PTEN(227), RPS6KB1(3) 10144798 626 216 412 47 90 121 129 39 203 44 <1.00e-15 4.44e-15 6.22e-14 45 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(7), APOA1(3), APOA2(2), CD36(8), CPT1B(6), CREBBP(32), DUSP1(2), EHHADH(10), EP300(32), FABP1(4), HSD17B4(12), INS(1), JUN(1), LPL(16), MAPK1(2), MAPK3(3), ME1(12), MRPL11(1), MYC(8), NCOA1(19), NCOR1(22), NCOR2(24), NFKBIA(3), NR0B2(2), NR1H3(4), NR2F1(7), NRIP1(17), PDGFA(3), PIK3CA(172), PIK3R1(99), PPARA(2), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), PTGS2(9), RB1(26), RELA(6), RXRA(3), SP1(7), STAT5A(5), STAT5B(7) 22410854 637 204 510 99 135 184 156 8 131 23 2.41e-10 4.55e-15 6.23e-14 46 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(4), ASAH1(6), ATF1(6), BRAF(10), CAMP(1), CREB1(5), CREB5(5), CREBBP(32), CRKL(6), DAG1(6), EGR1(6), EGR2(6), EGR3(7), EGR4(5), ELK1(3), FRS2(5), GNAQ(3), JUN(1), MAP1B(35), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(10), MAPK3(3), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4), NTRK1(13), OPN1LW(7), PIK3C2G(16), PIK3CA(172), PIK3CD(12), PIK3R1(99), PTPN11(8), RPS6KA3(19), SHC1(6), SRC(3), TERF2IP(2), TH(3) 18159846 569 205 444 97 128 175 125 5 119 17 1.35e-08 5.11e-15 6.43e-14 47 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(4), CREB1(5), GRB2(3), HRAS(1), MAPK1(2), MAPK3(3), MAPK7(14), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), NTRK1(13), PIK3CA(172), PIK3R1(99), PLCG1(12), RPS6KA1(1), SHC1(6) 7017966 356 198 236 34 64 91 94 6 86 15 3.62e-10 5.11e-15 6.43e-14 48 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(3), PAK1(3), PDGFRA(24), PIK3CA(172), PIK3R1(99), RAC1(1), WASL(8) 4979142 331 195 211 14 51 82 91 4 87 16 <1.00e-15 5.11e-15 6.43e-14 49 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), JAK1(20), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(11), PDGFA(3), PDGFRA(24), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), RAF1(9), RASA1(29), SHC1(6), SOS1(13), SRF(3), STAT1(15), STAT3(11), STAT5A(5) 12730148 507 202 376 51 93 135 132 4 125 18 1.04e-13 5.22e-15 6.43e-14 50 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(21), DIAPH1(12), FYN(5), GSN(4), HRAS(1), ITGA1(17), ITGB1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(2), MYLK(14), PFN1(1), PIK3CA(172), PIK3R1(99), PTK2(12), PXN(6), RAF1(9), ROCK1(22), SHC1(6), SRC(3), TLN1(23) 13836087 444 199 324 50 90 122 113 4 97 18 1.68e-10 5.22e-15 6.43e-14 51 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(21), ARHGEF1(12), F2(8), F2R(6), GNA12(7), GNA13(7), GNAI1(5), GNAQ(3), GNB1(2), GNGT1(1), MAP3K7(9), PIK3CA(172), PIK3R1(99), PLCB1(5), PPP1R12B(19), PRKCA(11), PTK2B(15), ROCK1(22) 9289594 424 199 301 59 94 105 110 7 90 18 5.10e-07 5.66e-15 6.84e-14 52 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(3), ARF3(4), CCND1(14), CDK2(2), CDK4(2), CDKN1A(1), CDKN1B(7), CDKN2A(1), CFL1(1), E2F1(9), E2F2(3), MDM2(5), PRB1(2), TP53(74) 2834146 128 98 102 21 33 37 31 1 26 0 0.00296 5.88e-15 6.97e-14 53 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(9), EGF(19), EGFR(12), ELK1(3), FOS(3), GRB2(3), HRAS(1), JAK1(20), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(11), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), RAF1(9), RASA1(29), SHC1(6), SOS1(13), SRF(3), STAT1(15), STAT3(11), STAT5A(5) 13675029 511 200 380 56 97 136 129 4 128 17 2.51e-12 6.00e-15 6.97e-14 54 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(54), ATR(38), CDC25C(5), CHEK1(2), CHEK2(13), TP53(74), YWHAH(3) 5921097 189 102 161 19 41 58 40 1 45 4 8.53e-05 6.88e-15 7.83e-14 55 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CALM2(3), CD3D(6), CD3E(2), CD3G(3), ELK1(3), FOS(3), FYN(5), GRB2(3), HRAS(1), JUN(1), LCK(4), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(11), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NFKB1(10), NFKBIA(3), PIK3CA(172), PIK3R1(99), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKCA(11), PTPN7(6), RAC1(1), RAF1(9), RASA1(29), RELA(6), SHC1(6), SOS1(13), SYT1(4), VAV1(12), ZAP70(8) 17112318 547 201 418 76 115 154 126 5 130 17 4.55e-10 6.99e-15 7.83e-14 56 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(4), AKT2(6), AKT3(11), BCR(6), BTK(12), CD19(4), CDKN2A(1), DAPP1(9), FLOT1(1), FLOT2(2), GAB1(7), ITPR1(34), ITPR2(35), ITPR3(22), LYN(9), NR0B2(2), PDK1(2), PHF11(5), PIK3CA(172), PITX2(8), PLCG2(27), PPP1R13B(9), PREX1(25), PTEN(227), PTPRC(17), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KB1(3), SAG(6), SYK(4), TEC(7), VAV1(12) 20146159 722 212 526 128 140 212 138 38 163 31 5.16e-09 6.43e-14 7.07e-13 57 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(54), CDC25A(8), CDC25B(3), CDC25C(5), CDK2(2), CDK4(2), CHEK1(2), MYT1(18), RB1(26), TP53(74), WEE1(2), YWHAH(3) 6552026 199 105 169 25 52 58 39 1 43 6 6.55e-05 1.46e-11 1.58e-10 58 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(4), AKT2(6), AKT3(11), BRAF(10), CAB39(6), DDIT4(2), EIF4B(7), FIGF(5), HIF1A(16), IGF1(5), INS(1), MAPK1(2), MAPK3(3), PDPK1(3), PGF(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PRKAA1(8), PRKAA2(11), RHEB(3), RICTOR(21), RPS6(7), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA6(19), RPS6KB1(3), RPS6KB2(4), STK11(2), TSC1(12), TSC2(14), ULK1(5), ULK2(11), ULK3(5), VEGFA(2), VEGFB(3), VEGFC(6) 18585019 602 207 472 95 135 170 147 5 128 17 3.10e-08 4.45e-11 4.73e-10 59 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(17), ATM(54), ATR(38), BAI1(10), BAX(2), BID(2), CASP3(4), CASP8(21), CASP9(3), CCNB1(8), CCNB2(5), CCNB3(33), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNG1(9), CCNG2(2), CD82(5), CDK2(2), CDK4(2), CDK6(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(13), CYCS(2), DDB2(6), EI24(3), FAS(8), GADD45G(1), GTSE1(2), IGF1(5), IGFBP3(4), MDM2(5), MDM4(4), PERP(4), PPM1D(13), PTEN(227), RCHY1(5), RFWD2(4), RRM2(6), RRM2B(5), SERPINB5(1), SERPINE1(5), SESN1(5), SESN2(3), SESN3(15), SIAH1(6), STEAP3(9), THBS1(10), TNFRSF10B(5), TP53(74), TP53I3(2), TP73(5), TSC2(14), ZMAT3(11) 23077507 747 225 616 132 129 216 126 34 208 34 2.59e-07 3.06e-08 3.20e-07 60 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(6), ACTR3(1), AKT1(4), AKT2(6), AKT3(11), ANGPTL2(6), ARHGAP1(2), ARHGAP4(10), ARHGEF11(20), BTK(12), CDC42(3), CFL1(1), CFL2(8), GDI1(4), GDI2(1), INPPL1(18), ITPR1(34), ITPR2(35), ITPR3(22), LIMK1(8), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3CG(23), PIK3R1(99), PITX2(8), PPP1R13B(9), PTEN(227), RACGAP1(9), RHO(4), ROCK1(22), ROCK2(17), RPS4X(1), SAG(6), WASF1(3), WASL(8) 25475732 891 219 670 155 164 251 158 38 235 45 4.19e-09 6.55e-08 6.72e-07 61 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(56), AXIN1(9), BTRC(14), CCND1(14), CREBBP(32), CSNK1A1(3), CSNK1D(3), CSNK2A1(9), CTBP1(1), CTNNB1(80), DVL1(3), FZD1(3), GSK3B(13), HDAC1(5), MAP3K7(9), MYC(8), NLK(5), PPARD(3), PPP2CA(6), TLE1(13), WIF1(5), WNT1(1) 10502166 295 132 228 48 65 138 47 2 39 4 4.11e-06 7.25e-08 7.32e-07 62 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(32), DAXX(9), HRAS(1), PAX3(5), PML(6), RARA(2), RB1(26), SIRT1(6), SP100(20), TNFRSF1A(4), TNFRSF1B(2), TP53(74) 6641355 187 97 159 30 59 53 33 1 36 5 7.03e-05 1.47e-06 1.46e-05 63 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(4), AKT2(6), AKT3(11), BAD(1), BCL2L1(4), CDC42(3), CDK2(2), CDKN1B(7), CDKN2A(1), CREB1(5), CREB5(5), EBP(2), ERBB4(27), F2RL2(2), GAB1(7), GRB2(3), GSK3A(10), GSK3B(13), IGF1(5), IGFBP1(4), INPPL1(18), IRS1(13), IRS4(20), MET(17), MYC(8), NOLC1(14), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PARD3(19), PDK1(2), PIK3CA(172), PIK3CD(12), PPP1R13B(9), PREX1(25), PTEN(227), PTK2(12), PTPN1(5), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KB1(3), SHC1(6), SLC2A4(9), SOS1(13), SOS2(17), TSC1(12), TSC2(14), YWHAE(5), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1) 26909150 850 216 647 148 180 235 181 41 182 31 5.29e-11 2.60e-06 2.54e-05 64 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(6), CDK2(2), CUL1(13), E2F1(9), FBXW7(44), RB1(26), TFDP1(13) 3092136 113 60 95 17 42 31 17 1 18 4 0.000350 4.14e-05 0.000398 65 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(17), ATM(54), BAX(2), CCND1(14), CCNE1(6), CDK2(2), CDK4(2), CDKN1A(1), E2F1(9), MDM2(5), PCNA(3), RB1(26), TIMP3(7), TP53(74) 6638149 222 116 192 34 45 69 52 1 49 6 0.000464 4.47e-05 0.000424 66 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(54), ATR(38), BRCA1(17), BRCA2(52), CHEK1(2), CHEK2(13), FANCA(15), FANCC(9), FANCD2(11), FANCE(10), FANCF(1), FANCG(10), HUS1(3), MRE11A(10), RAD1(6), RAD17(13), RAD50(18), RAD51(2), RAD9A(2), TP53(74) 16271430 360 118 328 44 74 142 72 1 65 6 1.44e-07 0.000152 0.00142 67 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(6), ACTR3(1), AKT1(4), ANGPTL2(6), DAG1(6), DGKA(9), ETFA(5), GCA(3), ITGA9(16), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), MAP2K1(2), MAPK1(2), MAPK3(3), NR1I3(4), PAK1(3), PDE3A(19), PDE3B(15), PI3(2), PIK3C2G(16), PIK3CA(172), PIK3CD(12), PIK3R1(99), PSME1(1), RIPK3(5), RPS4X(1), SGCB(4), VASP(3) 17891218 522 204 400 100 111 155 116 6 117 17 4.23e-05 0.000258 0.00237 68 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(4), APC(56), AR(12), ASAH1(6), BRAF(10), CAMP(1), CCL13(2), CCL15(1), CCL16(1), DAG1(6), EGFR(12), GNA11(2), GNA15(1), GNAI1(5), GNAQ(3), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), MAPK10(10), MAPK14(4), PHKA2(21), PIK3CA(172), PIK3CD(12), PIK3R1(99), PITX2(8), PTX3(2), RAF1(9), SRC(3) 19350915 587 210 461 118 120 188 126 7 126 20 3.01e-05 0.00249 0.0225 69 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(4), AKT2(6), AKT3(11), BAD(1), BCR(6), BLNK(4), BTK(12), CD19(4), CSK(1), DAG1(6), EPHB2(11), GRB2(3), ITPKA(1), ITPKB(11), LYN(9), MAP2K1(2), MAP2K2(5), MAPK1(2), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), PI3(2), PIK3CA(172), PIK3CD(12), PIK3R1(99), PLCG2(27), PPP1R13B(9), RAF1(9), SERPINA4(4), SHC1(6), SOS1(13), SOS2(17), SYK(4), VAV1(12) 18448082 531 202 405 110 114 162 126 6 107 16 0.000513 0.0102 0.0911 70 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(5), IMPA1(3), IMPA2(6), INPP1(3), INPP4A(19), INPP4B(16), INPP5A(4), INPP5B(5), INPP5E(1), INPPL1(18), IPMK(4), ISYNA1(2), ITPK1(4), ITPKA(1), ITPKB(11), MINPP1(3), MIOX(5), OCRL(19), PI4KA(17), PI4KB(9), PIK3C3(14), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(6), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(4), PLCD3(3), PLCD4(10), PLCE1(39), PLCG1(12), PLCG2(27), PLCZ1(13), PTEN(227), PTPMT1(2), SYNJ1(29), SYNJ2(11) 26523385 847 212 647 164 200 221 175 40 183 28 1.82e-08 0.0108 0.0950 71 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(4), AKT2(6), AKT3(11), CISH(2), GRB2(3), IARS(8), IL13RA1(11), IL2RG(11), IL4(1), IL4R(6), INPP5D(9), JAK1(20), JAK2(17), JAK3(10), NR0B2(2), PI3(2), PIK3CA(172), PPP1R13B(9), RPS6KB1(3), SERPINA4(4), SHC1(6), SOS1(13), SOS2(17), SRC(3), STAT6(10), TYK2(10) 13260226 370 155 269 72 74 134 109 6 43 4 0.000163 0.0120 0.104 72 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(12), AKT1(4), AKT2(6), AKT3(11), APAF1(17), ATM(54), BAD(1), BAX(2), BCL2L1(4), BID(2), BIRC2(10), BIRC3(5), CAPN1(5), CAPN2(11), CASP10(8), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CFLAR(2), CHUK(8), CSF2RB(14), CYCS(2), DFFB(4), ENDOG(1), FADD(1), FAS(8), FASLG(7), IKBKB(13), IKBKG(3), IL1B(2), IL1R1(5), IL1RAP(8), IL3(2), IL3RA(9), IRAK1(4), IRAK2(9), IRAK3(10), IRAK4(7), MYD88(2), NFKB1(10), NFKB2(9), NFKBIA(3), NTRK1(13), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RELA(6), RIPK1(8), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFRSF1A(4), TNFSF10(1), TP53(74), TRAF2(3) 30167075 856 231 696 153 182 273 181 6 195 19 3.25e-09 0.0496 0.424 73 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(3) 187727 3 3 3 1 0 1 0 1 1 0 0.806 0.198 1.000 74 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(4), AKT2(6), AKT3(11), BTK(12), CSF2(1), FCER1A(9), FCER1G(2), FYN(5), GAB2(10), GRB2(3), HRAS(1), IL3(2), IL4(1), IL5(2), INPP5D(9), KRAS(52), LCP2(5), LYN(9), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(11), MAPK9(4), MS4A2(3), NRAS(9), PDK1(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCG1(12), PLCG2(27), PRKCA(11), PRKCD(5), PRKCE(10), RAC1(1), RAC2(2), RAF1(9), SOS1(13), SOS2(17), SYK(4), VAV1(12), VAV2(7), VAV3(13) 25702425 775 211 597 150 179 259 169 9 143 16 1.99e-07 0.201 1.000 75 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(4), AKT2(6), AKT3(11), BAD(1), CASP9(3), CDC42(3), HRAS(1), KDR(26), KRAS(52), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPKAPK2(5), MAPKAPK3(5), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NOS3(11), NRAS(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCG1(12), PLCG2(27), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRKCA(11), PRKCG(8), PTGS2(9), PTK2(12), PXN(6), RAC1(1), RAC2(2), RAF1(9), SH2D2A(2), SHC2(5), SPHK1(2), SPHK2(2), SRC(3), VEGFA(2) 25185120 741 210 567 148 188 240 161 8 129 15 2.51e-07 0.235 1.000 76 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(6), CSF1(6), IL6(5), LDLR(7), LPL(16) 1914084 40 24 40 6 10 15 9 0 6 0 0.0247 0.246 1.000 77 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(6), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6) 1210424 26 16 26 5 2 17 0 0 7 0 0.164 0.265 1.000 78 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT1(4), AKT2(6), AKT3(11), BCL10(3), BLNK(4), BTK(12), CARD11(22), CD19(4), CD22(14), CD72(1), CD79A(1), CD79B(2), CHUK(8), CR2(22), FCGR2B(3), FOS(3), GSK3B(13), HRAS(1), IKBKB(13), IKBKG(3), INPP5D(9), JUN(1), KRAS(52), LILRB3(4), LYN(9), MALT1(4), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NRAS(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG2(27), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PTPN6(5), RAC1(1), RAC2(2), RASGRP3(11), SYK(4), VAV1(12), VAV2(7), VAV3(13) 26552098 770 208 600 155 176 269 165 7 138 15 3.84e-07 0.299 1.000 79 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(8), ATM(54), BRCA1(17), CDKN1A(1), CHEK1(2), CHEK2(13), JUN(1), MAPK8(11), MDM2(5), MRE11A(10), NFKB1(10), NFKBIA(3), RAD50(18), RAD51(2), RBBP8(11), RELA(6), TP53(74), TP73(5) 10702357 251 112 223 46 54 82 55 1 56 3 0.00723 0.310 1.000 80 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(8) 264662 8 6 8 1 2 4 2 0 0 0 0.297 0.310 1.000 81 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(6), CD3E(2), CD3G(3) 433293 11 7 11 1 1 7 0 0 3 0 0.181 0.401 1.000 82 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(4), APAF1(17), ATM(54), BAD(1), BAX(2), BCL2L1(4), BID(2), CASP3(4), CASP6(7), CASP7(1), CASP9(3), CYCS(2), EIF2S1(2), PRKCA(11), PTK2(12), PXN(6), STAT1(15), TLN1(23), TP53(74) 10101713 244 115 215 47 64 73 53 1 50 3 0.00255 0.419 1.000 83 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(32), AKT1(4), ATM(54), BAX(2), CDKN1A(1), CPB2(7), CSNK1A1(3), CSNK1D(3), FHL2(2), HIF1A(16), IGFBP3(4), MAPK8(11), MDM2(5), NFKBIB(1), NQO1(3), TP53(74) 7267170 222 112 192 44 54 66 49 2 46 5 0.0203 0.429 1.000 84 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(6), CDK2(2), CDKN1B(7), CKS1B(1), CUL1(13), E2F1(9), RB1(26), RBX1(1), SKP2(6), TFDP1(13) 3169643 84 38 82 17 26 25 17 0 13 3 0.0292 0.432 1.000 85 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(6), GSTZ1(5), HGD(4) 822142 15 12 15 2 5 4 4 0 2 0 0.107 0.458 1.000 86 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(11), APC(56), AXIN1(9), BTRC(14), CTNNB1(80), DLL1(6), DVL1(3), FZD1(3), GSK3B(13), NOTCH1(10), PSEN1(5), WNT1(1) 6996633 211 110 152 51 38 111 31 2 25 4 0.0289 0.477 1.000 87 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(5), SLPI(2) 572860 7 7 6 0 1 4 2 0 0 0 0.148 0.525 1.000 88 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(6), TPI1(2) 582980 8 7 8 1 0 3 1 0 4 0 0.273 0.535 1.000 89 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(4), AKT2(6), AKT3(11), BAD(1), BCR(6), BLNK(4), BTK(12), CD19(4), CD22(14), CR2(22), CSK(1), DAG1(6), FLOT1(1), FLOT2(2), GRB2(3), GSK3A(10), GSK3B(13), INPP5D(9), ITPR1(34), ITPR2(35), ITPR3(22), LYN(9), MAP4K1(12), MAPK1(2), MAPK3(3), NFATC1(10), NFATC2(13), NR0B2(2), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(99), PLCG2(27), PPP1R13B(9), PPP3CA(4), PPP3CB(6), PPP3CC(6), PTPRC(17), RAF1(9), SHC1(6), SOS1(13), SOS2(17), SYK(4), VAV1(12) 26363173 686 203 557 147 161 219 152 8 129 17 2.79e-05 0.538 1.000 90 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(9), GOT2(3), TAT(7) 959929 19 13 19 2 6 6 5 1 1 0 0.0879 0.563 1.000 91 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(4), CD34(1), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD58(2), CD8A(2), CSF3(1), IL3(2), IL6(5), KITLG(3) 2309359 37 26 37 9 4 19 4 0 10 0 0.256 0.611 1.000 92 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(8), ATM(54), ATR(38), CCNA1(5), CCND1(14), CCNE1(6), CDC25A(8), CDK2(2), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(7), CDKN2A(1), DHFR(4), E2F1(9), GSK3B(13), HDAC1(5), RB1(26), SKP2(6), TFDP1(13), TGFB1(1), TGFB2(5), TGFB3(9), TP53(74) 10840158 314 131 282 66 80 97 58 1 71 7 0.00755 0.613 1.000 93 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(6), ACAT2(4), HMGCL(2), OXCT1(10) 1250166 22 15 21 3 8 7 3 0 4 0 0.118 0.615 1.000 94 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(6), LPL(16), NR3C1(17), PPARG(6), RETN(1), RXRA(3) 1931315 49 24 48 9 12 19 7 1 10 0 0.0334 0.644 1.000 95 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(5), CCNA2(7), CCND1(14), CCNE1(6), CCNE2(8), CDK2(2), CDK4(2), CDKN1B(7), CDKN2A(1), E2F1(9), E2F2(3), E2F4(3), PRB1(2) 3060313 69 43 67 16 9 26 21 0 13 0 0.199 0.684 1.000 96 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(5), FOS(3), JUN(1), KEAP1(8), MAFK(1), MAPK1(2), MAPK14(4), MAPK8(11), NFE2L2(14), PRKCA(11) 3125025 60 39 57 11 16 15 16 3 10 0 0.0291 0.690 1.000 97 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(8), GOT1(9), GOT2(3), TAT(7), TYR(12) 1718364 39 20 39 5 10 13 12 1 3 0 0.0300 0.706 1.000 98 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(4), AKT2(6), AKT3(11), CASP8(21), CCL4(5), CCL5(2), CD14(2), CD40(1), CD80(5), CD86(5), CHUK(8), CXCL10(2), CXCL9(2), FADD(1), FOS(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IKBKB(13), IKBKE(4), IKBKG(3), IL12A(5), IL12B(2), IL1B(2), IL6(5), IRAK1(4), IRAK4(7), IRF3(2), IRF5(6), IRF7(1), JUN(1), LBP(3), LY96(4), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K7(9), MAP3K8(10), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(11), MAPK9(4), MYD88(2), NFKB1(10), NFKB2(9), NFKBIA(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), RAC1(1), RELA(6), RIPK1(8), SPP1(2), STAT1(15), TBK1(7), TICAM1(5), TIRAP(2), TLR1(15), TLR2(16), TLR3(10), TLR4(17), TLR5(14), TLR6(14), TLR7(17), TLR8(18), TLR9(6), TOLLIP(1), TRAF3(5), TRAF6(7) 31810954 851 209 718 173 196 276 194 5 164 16 3.94e-07 0.707 1.000 99 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(8), IFNG(10), IL12A(5), IL12B(2), IL18(2), IL2(2) 1135018 29 20 28 7 9 9 5 1 5 0 0.350 0.717 1.000 100 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(8), APC(56), ATF2(8), AXIN1(9), BMP10(9), BMP2(6), BMP4(10), BMP5(14), BMP7(12), BMPR1A(5), BMPR2(12), CHRD(12), CTNNB1(80), DVL1(3), FZD1(3), GATA4(3), GSK3B(13), MAP3K7(9), MEF2C(10), MYL2(2), NKX2-5(2), NOG(2), NPPA(2), NPPB(2), RFC1(21), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6), TGFBR3(15), WNT1(1) 12863550 356 130 293 73 89 168 52 3 41 3 0.000305 0.721 1.000 101 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(6), ALDOA(5), ALDOB(9), ALDOC(3), TPI1(2) 1409129 25 16 24 4 8 5 5 0 7 0 0.0994 0.744 1.000 102 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(17), BMPR1A(5), BMPR1B(6), BMPR2(12) 2246825 40 22 40 5 13 14 7 2 4 0 0.0361 0.760 1.000 103 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(5), ASPH(11), COPS5(5), CREB1(5), EDN1(4), EP300(32), EPO(3), HIF1A(16), JUN(1), LDHA(6), NOS3(11), P4HB(5), VHL(3) 6084806 107 47 106 16 31 30 24 2 20 0 0.00109 0.796 1.000 104 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(4), CD4(6), HLA-DRA(1), IL1B(2), IL4(1), IL5(2), IL5RA(9), IL6(5) 1844183 30 21 28 8 3 13 3 0 11 0 0.280 0.813 1.000 105 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(5), CCNE1(6), CDK2(2), CUL1(13), E2F1(9), RB1(26), SKP2(6), TFDP1(13) 3172824 80 38 78 18 27 21 17 0 12 3 0.0491 0.851 1.000 106 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(8), SUCLA2(5) 775051 13 10 11 3 8 3 0 0 2 0 0.299 0.853 1.000 107 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(2), CCR3(4), CSF2(1), HLA-DRA(1), IL3(2), IL5(2) 970363 12 11 12 1 3 4 2 0 3 0 0.0945 0.867 1.000 108 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), HSD3B7(5), PON1(12), PON2(6), PON3(5), RDH11(1), RDH12(5), RDH13(4), RDH14(2) 3235853 60 31 58 11 19 21 10 1 9 0 0.0142 0.880 1.000 109 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(8), IDI1(3), SQLE(5) 1213914 17 12 17 2 4 8 4 0 1 0 0.167 0.885 1.000 110 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(7), COASY(11), DPYD(20), DPYS(6), ENPP1(12), ENPP3(17), PANK1(3), PANK2(7), PANK3(5), PANK4(5), PPCS(4), UPB1(10) 4910957 107 38 106 21 26 43 26 0 12 0 0.0140 0.904 1.000 111 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(32), EP300(32), ESR1(11), MAPK1(2), MAPK3(3), PELP1(9), SRC(3) 5444727 92 47 87 19 26 21 25 1 18 1 0.0389 0.920 1.000 112 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5) 2104861 29 19 29 6 11 5 7 0 6 0 0.109 0.933 1.000 113 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(17), BAK1(3), BAX(2), BCL2L1(4), BID(2), BIRC2(10), BIRC3(5), CASP2(6), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CYCS(2), FADD(1), FAS(8), FASLG(7), GZMB(4), IKBKG(3), JUN(1), MAP2K4(9), MAP3K1(30), MAPK10(10), MCL1(1), MDM2(5), MYC(8), NFKB1(10), NFKBIA(3), PARP1(9), PRF1(8), RELA(6), RIPK1(8), TNFRSF1A(4), TNFRSF1B(2), TNFSF10(1), TP53(74), TRAF1(5), TRAF2(3) 13320502 307 116 276 65 72 104 66 2 62 1 0.00136 0.944 1.000 114 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(2), FOSB(4), GRIA2(21), PPP1R1B(2) 1282432 29 17 28 8 8 7 6 0 8 0 0.307 0.947 1.000 115 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(8), ABL2(21), AKT1(4), AKT2(6), AKT3(11), ARAF(12), AREG(2), BAD(1), BRAF(10), BTC(2), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CBL(12), CBLB(12), CBLC(5), CDKN1A(1), CDKN1B(7), CRK(2), CRKL(6), EGF(19), EGFR(12), ELK1(3), ERBB2(10), ERBB3(19), ERBB4(27), EREG(3), GAB1(7), GRB2(3), GSK3B(13), HBEGF(2), HRAS(1), JUN(1), KRAS(52), MAP2K1(2), MAP2K2(5), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(10), MAPK3(3), MAPK8(11), MAPK9(4), MYC(8), NCK1(4), NCK2(8), NRAS(9), NRG1(19), NRG2(4), NRG3(15), NRG4(1), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(27), PRKCA(11), PRKCG(8), PTK2(12), RAF1(9), RPS6KB1(3), RPS6KB2(4), SHC1(6), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SRC(3), STAT5A(5), STAT5B(7) 36621303 981 215 801 197 241 335 207 7 173 18 1.29e-08 0.954 1.000 116 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(3), CD4(6), HLA-DRA(1) 743572 10 10 10 4 2 5 0 0 3 0 0.743 0.955 1.000 117 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(6), NDUFA4(1), NDUFA5(1), NDUFA8(5), NDUFB7(3), NDUFS1(13), NDUFS2(7), NDUFV1(3), NDUFV2(2) 2599039 42 26 41 8 18 10 5 1 7 1 0.116 0.959 1.000 118 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(8), ACTN1(9), ACTR2(6), ACTR3(1), AKT1(4), AKT2(6), AKT3(11), ANGPTL2(6), ARHGEF6(25), ARHGEF7(15), BCAR1(8), BRAF(10), CAV1(2), CDC42(3), CDKN2A(1), CRK(2), CSE1L(14), DOCK1(21), EPHB2(11), FYN(5), GRB2(3), GRB7(4), ILK(5), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(19), ITGA9(16), ITGB3BP(5), MAP2K4(9), MAP2K7(4), MAP3K11(5), MAPK1(2), MAPK10(10), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4), MRAS(2), MYLK(14), MYLK2(8), P4HB(5), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PIK3CA(172), PIK3CB(17), PKLR(6), PLCG1(12), PLCG2(27), PTEN(227), PTK2(12), RAF1(9), RALA(6), RHO(4), ROCK1(22), ROCK2(17), SHC1(6), SOS1(13), SOS2(17), SRC(3), TERF2IP(2), TLN1(23), TLN2(29), VASP(3), WAS(11), ZYX(11) 44169711 1094 216 882 229 244 323 222 39 232 34 4.85e-09 0.964 1.000 119 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(5), IFNG(10), IFNGR1(4), IFNGR2(4), IKBKB(13), JAK2(17), LIN7A(8), NFKB1(10), NFKBIA(3), RB1(26), RELA(6), TNFRSF1A(4), TNFRSF1B(2), TP53(74), USH1C(5), WT1(3) 6411700 194 94 169 44 53 62 36 2 35 6 0.0294 0.966 1.000 120 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(14), GABRA2(13), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(8), PRKCE(10), SOD1(2) 2901805 90 35 85 26 23 36 18 0 13 0 0.198 0.967 1.000 121 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP1(2), RANBP2(40), RANGAP1(3) 3100037 46 23 46 8 10 18 10 0 8 0 0.159 0.967 1.000 122 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(54), ATR(38), BRCA1(17), CCNB1(8), CDC25A(8), CDC25B(3), CDC25C(5), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(13), EP300(32), MDM2(5), MYT1(18), PRKDC(54), RPS6KA1(1), TP53(74), WEE1(2), YWHAH(3), YWHAQ(1) 15904811 340 118 307 63 74 103 82 4 73 4 0.000910 0.967 1.000 123 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(1), BAX(2), CASP8(21), CYCS(2), FADD(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(11), NFKB1(10), NSMAF(9), RAF1(9), RELA(6), RIPK1(8), SMPD1(4), TNFRSF1A(4), TRAF2(3) 7275526 137 49 133 29 27 47 27 0 35 1 0.0363 0.972 1.000 124 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(6), BFAR(7), BRAF(10), CAMP(1), CREB1(5), CREB5(5), MAPK1(2), RAF1(9), SNX13(15), SRC(3), TERF2IP(2) 4244786 65 28 64 12 14 25 14 1 11 0 0.0720 0.980 1.000 125 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(5), BIRC3(5), CASP8(21), FADD(1), RIPK1(8), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3) 2704555 49 29 47 12 9 17 9 0 14 0 0.205 0.983 1.000 126 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(54), CDC25A(8), CDC25B(3), CDC25C(5), CHEK1(2), MYT1(18), WEE1(2), YWHAH(3) 5100102 95 37 90 16 22 33 17 0 20 3 0.0368 0.986 1.000 127 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(3), FOSL1(3), FOSL2(7), IFNAR1(7), IFNAR2(8), IFNB1(3), MAPK8(11), NFKB1(10), RELA(6), TNFRSF11A(4), TNFSF11(7), TRAF6(7) 3947890 76 31 74 13 19 24 21 0 12 0 0.0149 0.987 1.000 128 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(6), CD3D(6), CD3E(2), CD3G(3), CXCR3(5), ETV5(3), IFNG(10), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18(2), IL18R1(9), JAK2(17), JUN(1), MAP2K6(10), MAPK14(4), MAPK8(11), STAT4(7), TYK2(10) 6885170 136 42 134 28 28 50 31 1 23 3 0.0180 0.987 1.000 129 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(1), CSF3(1), EPO(3), FLT3(16), IGF1(5), IL11(2), IL3(2), IL6(5), IL9(1), KITLG(3), TGFB1(1), TGFB2(5), TGFB3(9) 3069442 54 29 52 12 13 21 10 0 10 0 0.108 0.988 1.000 130 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(5), SHMT1(5), SHMT2(5) 1518951 16 13 16 3 7 5 2 0 2 0 0.154 0.990 1.000 131 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(2), IFNB1(3), IFNG(10), IL10(4), IL12A(5), IL12B(2), IL15(2), IL16(16), IL18(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL9(1), LTA(3) 3525903 62 27 61 16 15 25 11 1 10 0 0.114 0.990 1.000 132 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(19), EGFR(12), ERBB3(19), NRG1(19) 3749909 69 32 66 14 18 24 14 0 13 0 0.0975 0.991 1.000 133 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(7), PGLYRP2(4) 631323 11 9 10 7 2 6 0 0 3 0 0.959 0.991 1.000 134 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(8), CDC25B(3), CDK7(7), CDKN1A(1), CHEK1(2), NEK1(19), WEE1(2) 2797504 42 22 40 7 14 17 4 0 7 0 0.159 0.991 1.000 135 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(32), EP300(32), LPL(16), NCOA1(19), NCOA2(15), PPARG(6), RXRA(3) 6718199 123 50 119 26 31 36 31 2 22 1 0.0251 0.992 1.000 136 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(4), GPLD1(12), PGAP1(17), PIGA(8), PIGB(11), PIGC(3), PIGF(2), PIGG(6), PIGH(5), PIGK(9), PIGL(1), PIGM(1), PIGN(13), PIGO(9), PIGP(3), PIGQ(5), PIGS(1), PIGT(8), PIGU(2), PIGV(7), PIGW(9), PIGX(2), PIGZ(5) 8968278 143 49 140 25 36 55 34 0 18 0 0.000637 0.993 1.000 137 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(7), F13A1(8), F2(8), F2R(6), FGA(26), FGB(7), FGG(9), PLAT(6), PLG(14), SERPINB2(9), SERPINE1(5) 4979506 105 36 101 23 22 46 24 1 12 0 0.0358 0.994 1.000 138 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(5) 748071 11 8 11 4 3 6 0 0 2 0 0.762 0.994 1.000 139 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(4), BCKDK(5), CBS(11), CTH(6), MUT(10) 1755891 36 21 35 9 10 15 5 0 6 0 0.259 0.996 1.000 140 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(10), ALDH1A2(11), RDH5(3) 1414742 24 13 24 9 6 8 4 0 6 0 0.644 0.997 1.000 141 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(3), LIPT1(5) 566294 8 7 8 4 2 3 2 0 1 0 0.924 0.998 1.000 142 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(3), SRP19(3), SRP54(8), SRP68(5), SRP72(11), SRP9(1), SRPR(11) 2776480 43 21 43 8 10 21 6 0 6 0 0.182 0.998 1.000 143 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(7), AOC3(10), CES1(13), ESD(2) 2112292 32 19 29 7 9 11 9 0 3 0 0.159 0.998 1.000 144 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(9), GAD1(6), HDC(9), PNMT(2), TH(3), TPH1(9) 2023477 38 23 37 10 14 11 8 0 4 1 0.202 0.999 1.000 145 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(18), CD38(6), ENPP1(12), ENPP3(17), NADSYN1(6), NMNAT1(3), NMNAT2(3), NNMT(6), NNT(7), NT5C(1), NT5E(6), NT5M(2), QPRT(2) 5305520 89 31 87 20 21 37 27 0 4 0 0.0385 0.999 1.000 146 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(6), CD8A(2), CSF1(6), CSF2(1), CSF3(1), EPO(3), IL11(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL7(1), IL9(1) 2235970 35 29 35 11 8 14 4 1 8 0 0.374 0.999 1.000 147 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(7), NR0B2(2), NR1H3(4), NR1H4(7), RXRA(3) 1864144 26 18 26 6 9 6 4 1 6 0 0.193 0.999 1.000 148 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(5), CCNB1(8), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNH(7), CDC25A(8), CDK2(2), CDK4(2), CDK6(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(1), CDKN2C(4), CDKN2D(1), E2F1(9), RB1(26), RBL1(13), TFDP1(13) 5680949 150 55 144 32 43 42 30 0 32 3 0.0185 0.999 1.000 149 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(7), IFNAR2(8), IFNB1(3), JAK1(20), STAT1(15), STAT2(8), TYK2(10) 3919832 73 30 71 20 21 20 20 0 12 0 0.256 1.000 1.000 150 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(8), CCNH(7), CDC25A(8), CDC25B(3), CDC25C(5), CDK7(7), SHH(4), XPO1(18) 3154343 60 25 57 12 24 15 12 0 9 0 0.0956 1.000 1.000 151 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(9), NFYB(2), NFYC(3), RB1(26), SP1(7), SP3(10) 2477280 57 27 54 11 16 14 13 0 11 3 0.146 1.000 1.000 152 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(9), ENO1(6), GPI(7), HK1(11), PFKL(8), PGAM1(3), PGK1(7), PKLR(6), TPI1(2) 3222973 59 30 58 14 22 21 8 0 8 0 0.0560 1.000 1.000 153 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(8), GGPS1(2), IDI1(3), IDI2(1), SQLE(5) 1613940 20 13 20 5 5 10 4 0 1 0 0.474 1.000 1.000 154 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(11), CYP2A13(9), CYP2A6(13), CYP2A7(6), NAT1(7), NAT2(4), XDH(14) 2966743 64 35 60 17 19 30 8 0 7 0 0.117 1.000 1.000 155 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(4), ANKRD1(7), ATF3(3), CYR61(3), DUSP14(4), EIF4E(1), HBEGF(2), IFNG(10), IFRD1(6), IL18(2), IL1R1(5), MYOG(1), NR4A3(8), WDR1(7) 3908198 63 27 63 15 16 25 11 0 11 0 0.195 1.000 1.000 156 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(5), CR1(22), CR2(22), FCGR2B(3), HLA-DRA(1), ICAM1(2), ITGAL(17), ITGB2(15), PTPRC(17) 5411848 104 38 103 29 30 38 17 1 17 1 0.121 1.000 1.000 157 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(6), GSS(5), NFKB1(10), NOX1(16), RELA(6), SOD1(2), XDH(14) 3588806 59 26 59 13 15 21 13 1 9 0 0.106 1.000 1.000 158 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(6), ACAT2(4), BDH1(3), BDH2(4), HMGCL(2), HMGCS1(6), HMGCS2(9), OXCT1(10), OXCT2(2) 2682095 46 25 45 11 14 17 8 1 6 0 0.203 1.000 1.000 159 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(17), ARHGAP5(21), ARHGDIB(3), CASP1(8), CASP10(8), CASP3(4), CASP8(21), CASP9(3), CYCS(2), GZMB(4), JUN(1), PRF1(8) 4727581 100 34 96 25 21 36 20 0 22 1 0.241 1.000 1.000 160 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(3), CD86(5), HLA-DRA(1), IFNG(10), IFNGR1(4), IFNGR2(4), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18(2), IL18R1(9), IL2(2), IL2RA(4), IL4(1), IL4R(6) 4551927 81 32 80 25 27 28 14 1 11 0 0.266 1.000 1.000 161 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM2(3), CAMK1(3), CAMK1G(5), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CAMK4(5), CAMKK1(11), CAMKK2(6), CREB1(5), SYT1(4) 4149292 67 29 66 15 24 24 9 0 10 0 0.0383 1.000 1.000 162 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(6), CD2(4), CD3D(6), CD3E(2), CD3G(3), CD4(6), CXCR3(5), IFNG(10), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), JAK2(17), STAT4(7), TYK2(10) 5451266 106 38 105 29 21 48 17 1 16 3 0.231 1.000 1.000 163 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 B3GNT1(5), B3GNT2(1), B3GNT3(5), B3GNT4(4), B3GNT5(6), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), FUT7(2), FUT9(9), GCNT2(4), ST3GAL6(6), ST8SIA1(2) 5116187 90 36 89 21 39 28 12 1 10 0 0.0309 1.000 1.000 164 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(12), BID(2), BRAF(10), CASP3(4), CD244(6), CD247(5), CD48(2), CSF2(1), FAS(8), FASLG(7), FCER1G(2), FCGR3A(1), FYN(5), GRB2(3), GZMB(4), HCST(1), HLA-A(1), HLA-B(2), HLA-C(2), HLA-E(1), HLA-G(2), HRAS(1), ICAM1(2), ICAM2(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(10), IFNGR1(4), IFNGR2(4), ITGAL(17), ITGB2(15), KIR2DL3(1), KIR3DL1(10), KIR3DL2(5), KLRC1(7), KLRC2(1), KLRC3(2), KLRD1(3), KLRK1(1), KRAS(52), LCK(4), LCP2(5), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MICA(1), MICB(2), NCR1(6), NCR2(3), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NRAS(9), PAK1(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(27), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRF1(8), PRKCA(11), PRKCG(8), PTK2B(15), PTPN11(8), PTPN6(5), RAC1(1), RAC2(2), RAF1(9), SH2D1A(7), SH2D1B(4), SH3BP2(7), SHC1(6), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SYK(4), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(5), ULBP3(1), VAV1(12), VAV2(7), VAV3(13), ZAP70(8) 40242749 994 212 813 225 243 350 215 7 162 17 1.36e-06 1.000 1.000 165 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(10), IFNGR1(4), IFNGR2(4), JAK1(20), JAK2(17), STAT1(15) 3049904 70 31 69 21 19 21 13 0 14 3 0.472 1.000 1.000 166 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALM2(3), CALML3(3), CALML6(4), CDS1(5), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKI(18), DGKQ(2), DGKZ(10), FN3K(5), IMPA1(3), IMPA2(6), INPP1(3), INPP4A(19), INPP4B(16), INPP5A(4), INPP5B(5), INPP5D(9), INPP5E(1), INPPL1(18), ITPK1(4), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), OCRL(19), PI4KA(17), PI4KB(9), PIK3C2A(22), PIK3C2B(10), PIK3C2G(16), PIK3C3(14), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(6), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(4), PLCD3(3), PLCD4(10), PLCE1(39), PLCG1(12), PLCG2(27), PLCZ1(13), PRKCA(11), PRKCG(8), PTEN(227), PTPMT1(2), SYNJ1(29), SYNJ2(11) 45436750 1248 223 1021 279 292 339 249 42 281 45 4.19e-06 1.000 1.000 167 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6), ICAM1(2), ITGAL(17), ITGB2(15), PTPRC(17), THY1(1) 4083120 76 36 75 24 20 31 9 0 16 0 0.270 1.000 1.000 168 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(21), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(8), ANAPC7(5), BTRC(14), CDC16(11), CDC20(4), CDC23(5), CUL1(13), CUL2(12), CUL3(14), FBXW11(5), FBXW7(44), FZR1(2), ITCH(10), RBX1(1), SKP2(6), SMURF1(12), SMURF2(8), TCEB1(2), TCEB2(2), UBA1(17), UBE2C(1), UBE2D2(4), UBE2D3(2), UBE2D4(2), UBE2E1(4), UBE2E2(3), UBE2E3(6), VHL(3), WWP1(19), WWP2(9) 14140270 282 91 262 57 88 87 58 2 45 2 0.00215 1.000 1.000 169 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(10), IFNGR1(4), JAK1(20), JAK2(17), PTPRU(17), REG1A(4), STAT1(15) 4199450 89 36 88 24 31 25 14 0 16 3 0.219 1.000 1.000 170 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(9), ELK1(3), EPO(3), EPOR(4), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(11), PLCG1(12), PTPN6(5), RAF1(9), SHC1(6), SOS1(13), STAT5A(5), STAT5B(7) 7811814 117 48 110 26 32 45 26 0 11 3 0.0319 1.000 1.000 171 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3D(6), CD3E(2), CD3G(3), GZMB(4), HLA-A(1), ICAM1(2), ITGAL(17), ITGB2(15), PRF1(8) 3051150 61 32 59 18 24 22 4 0 11 0 0.0811 1.000 1.000 172 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(6), CD3E(2), CD3G(3), CD4(6), FYN(5), HLA-DRA(1), LCK(4), PTPRC(17), ZAP70(8) 3156865 52 25 52 14 11 21 7 0 13 0 0.264 1.000 1.000 173 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(20), JAK2(17), JAK3(10), PIAS1(7), PIAS3(9), PTPRU(17), REG1A(4), SOAT1(9) 5010873 95 37 94 25 28 32 17 1 14 3 0.175 1.000 1.000 174 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(6), CHRNA1(7), SNAP25(7), STX1A(1) 1177188 21 14 20 6 11 2 6 0 2 0 0.395 1.000 1.000 175 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(6), ENO2(4), ENO3(5), FARS2(2), GOT1(9), GOT2(3), PAH(2), TAT(7), YARS(5) 3043413 43 21 43 11 14 14 10 1 4 0 0.248 1.000 1.000 176 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(5), IL6R(7), JAK1(20), JAK2(17), JAK3(10), PIAS3(9), PTPRU(17), REG1A(4), SRC(3), STAT3(11) 5492541 105 41 104 28 27 35 21 1 18 3 0.148 1.000 1.000 177 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(5), RAB11A(2), RAB1A(5), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(2), RAB6A(1), RAB9A(6) 1589158 32 17 30 10 13 8 5 0 6 0 0.326 1.000 1.000 178 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(5), GLS(11), GLUD1(3), OAT(7), PRODH(10) 2002359 40 21 37 12 12 13 7 1 7 0 0.397 1.000 1.000 179 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(14), FOS(3), GRB2(3), HRAS(1), IL3(2), IL3RA(9), JAK2(17), MAP2K1(2), MAPK3(3), PTPN6(5), RAF1(9), SHC1(6), SOS1(13), STAT5A(5), STAT5B(7) 6359638 99 43 95 26 29 42 20 0 5 3 0.134 1.000 1.000 180 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(7), CLOCK(9), CRY1(9), CRY2(3), CSNK1D(3), CSNK1E(3), NPAS2(13), NR1D1(4), PER1(10), PER2(13), PER3(15) 6067688 89 40 85 22 30 34 14 1 10 0 0.0646 1.000 1.000 181 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 B3GNT1(5), FUT1(4), FUT2(1), FUT9(9), GCNT2(4), ST8SIA1(2) 1973787 25 15 25 8 13 6 5 0 1 0 0.321 1.000 1.000 182 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD8A(2), ICAM1(2), ITGAL(17), ITGB2(15), PTPRC(17), THY1(1) 3842727 72 32 71 23 22 28 9 0 13 0 0.241 1.000 1.000 183 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(2), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), SHMT1(5) 5607042 105 43 103 28 26 39 13 0 26 1 0.179 1.000 1.000 184 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(2), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), SHMT1(5) 5607042 105 43 103 28 26 39 13 0 26 1 0.179 1.000 1.000 185 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(2), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), SHMT1(5) 5607042 105 43 103 28 26 39 13 0 26 1 0.179 1.000 1.000 186 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IL6(5), IL6R(7), IL6ST(11), JAK1(20), JAK2(17), JAK3(10), JUN(1), MAP2K1(2), MAPK3(3), PTPN11(8), RAF1(9), SHC1(6), SOS1(13), SRF(3), STAT3(11) 8536621 145 55 139 32 31 55 35 0 21 3 0.0296 1.000 1.000 187 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(5), TAX1BP3(1), UBE2A(3), UBE2B(3), UBE2C(1), UBE2D2(4), UBE2D3(2), UBE2E1(4), UBE2E3(6), UBE2G1(2), UBE2H(1), UBE2J1(2), UBE2L3(2), UBE2L6(3), UBE2N(4), UBE3A(16) 3762990 59 28 59 15 15 14 15 2 13 0 0.206 1.000 1.000 188 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(3), ALAS1(8), ALAS2(10), CPO(3), FECH(7), GATA1(8), HBA1(1), HBA2(1), HBB(2), HMBS(8), UROD(3), UROS(3) 3008529 57 27 55 15 19 22 10 0 6 0 0.235 1.000 1.000 189 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(21), ADRB2(7), CFTR(14), GNAS(24), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), SLC9A3R1(2) 4521301 95 36 91 26 38 27 15 1 13 1 0.139 1.000 1.000 190 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(2), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), FDXR(2), SHMT1(5) 5871170 107 43 105 28 27 39 14 0 26 1 0.150 1.000 1.000 191 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(7), ACOX3(8), FADS2(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9) 3783753 62 33 59 18 25 18 5 2 12 0 0.187 1.000 1.000 192 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(7), IARS(8), LARS(18), LARS2(8), PDHA1(7), PDHA2(9), PDHB(3) 3714074 60 23 59 14 10 28 9 0 13 0 0.347 1.000 1.000 193 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(14), AGT(8), AGTR1(4), AGTR2(11), BDKRB2(8), KNG1(11), NOS3(11), REN(4) 3394668 71 29 68 20 31 28 6 1 5 0 0.0819 1.000 1.000 194 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(5), APAF1(17), CASP3(4), CASP9(3), CYCS(2), DAXX(9), FAS(8), FASLG(7), HSPB2(1), MAPKAPK2(5), MAPKAPK3(5) 3917860 66 27 65 16 15 24 17 0 10 0 0.186 1.000 1.000 195 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(3), TGDS(4), UGDH(2), UGP2(6), UXS1(5) 1872620 20 15 19 7 6 7 5 0 2 0 0.734 1.000 1.000 196 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(17), BAD(1), BAK1(3), BAX(2), BCL10(3), BCL2L1(4), BCL2L11(6), BID(2), CASP9(3), CES1(13) 2783428 54 26 53 13 9 21 16 0 8 0 0.263 1.000 1.000 197 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19) 4725130 104 33 99 27 21 45 23 0 13 2 0.219 1.000 1.000 198 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), NFS1(5), PHPT1(1), TPK1(3) 2334275 42 20 41 10 10 17 7 0 8 0 0.397 1.000 1.000 199 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(6), FARSB(7), GOT1(9), GOT2(3), PAH(2), TAT(7), YARS(5), YARS2(3) 3194444 44 24 44 12 15 14 11 1 3 0 0.324 1.000 1.000 200 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(7), CLOCK(9), CRY1(9), CRY2(3), CSNK1E(3), PER1(10) 3037182 41 24 40 10 12 17 6 1 5 0 0.298 1.000 1.000 201 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(3), ACP2(1), ACP5(5), ACPP(6), ACPT(5), ENPP1(12), ENPP3(17), FLAD1(4), RFK(1), TYR(12) 3572293 66 25 66 15 9 26 25 0 6 0 0.203 1.000 1.000 202 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(5), COQ5(1), COQ6(4), COQ7(3), NDUFA13(1), NDUFB11(3) 1527536 17 15 17 8 8 5 2 0 2 0 0.847 1.000 1.000 203 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(3), INPP1(3), INPP4A(19), INPP4B(16), INPP5A(4), INPPL1(18), ITPKA(1), ITPKB(11), MIOX(5), OCRL(19), PIK3C2A(22), PIK3C2B(10), PIK3C2G(16), PIK3CA(172), PIK3CB(17), PIK3CG(23), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(4), PLCG1(12), PLCG2(27) 16343503 445 161 341 101 125 139 116 5 59 1 0.00207 1.000 1.000 204 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT1(4), AKT2(6), AKT3(11), BCL10(3), CARD11(22), CBL(12), CBLB(12), CBLC(5), CD247(5), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD40LG(6), CD8A(2), CD8B(1), CDC42(3), CDK4(2), CHUK(8), CSF2(1), CTLA4(2), FOS(3), FYN(5), GRB2(3), HRAS(1), ICOS(3), IFNG(10), IKBKB(13), IKBKG(3), IL10(4), IL2(2), IL4(1), IL5(2), ITK(7), JUN(1), KRAS(52), LCK(4), LCP2(5), MALT1(4), MAP3K8(10), NCK1(4), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NRAS(9), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PDCD1(3), PDK1(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRKCQ(9), PTPN6(5), PTPRC(17), RASGRP1(8), RHOA(3), SOS1(13), SOS2(17), TEC(7), VAV1(12), VAV2(7), VAV3(13), ZAP70(8) 36166709 900 211 723 203 217 299 195 10 162 17 6.34e-05 1.000 1.000 205 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(17), BAK1(3), BAX(2), BCL2L1(4), BID(2), BIK(2), BIRC2(10), BIRC3(5), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CYCS(2), DFFB(4), DIABLO(3), ENDOG(1) 4938447 91 33 88 24 15 35 19 0 22 0 0.360 1.000 1.000 206 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(22), AGT(8), AGTR1(4), AGTR2(11), CMA1(2), COL4A1(21), COL4A2(14), COL4A3(25), COL4A4(23), COL4A5(26), COL4A6(31), REN(4) 9494645 191 50 185 46 41 98 23 2 23 4 0.0224 1.000 1.000 207 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(3), ECHS1(3), HADH(1), HADHA(5), HADHB(4), HSD17B10(4), HSD17B4(12), MECR(5), PPT1(3), PPT2(1) 3035384 41 26 40 12 7 15 14 1 4 0 0.438 1.000 1.000 208 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(6), HLCS(6), SPCS3(2) 1133663 14 10 14 9 2 3 8 0 1 0 0.967 1.000 1.000 209 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 ALDOA(5), CTSD(4), ESR1(11), GREB1(19), HSPB2(1), MTA1(6), MTA3(6), PDZK1(5), TUBA8(7) 3584758 64 38 63 18 21 16 16 3 8 0 0.164 1.000 1.000 210 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(10), GALNT10(8), GALNT2(10), GALNT3(8), GALNT4(8), GALNT6(1), GALNT7(12), GALNT8(11), GALNT9(8), GCNT1(5), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), WBSCR17(15) 5377050 107 41 105 29 30 40 27 1 9 0 0.174 1.000 1.000 211 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(21), GNAS(24), GNB1(2), GNGT1(1), PRKACA(6), PRKAR1A(4) 2172411 58 29 56 15 29 14 8 0 7 0 0.211 1.000 1.000 212 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(5), ASL(2), CPS1(22), GLS(11), GLUD1(3), GOT1(9) 2808232 52 22 51 13 10 21 8 1 10 2 0.316 1.000 1.000 213 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(3), ACP2(1), ACP5(5), ACP6(4), ACPP(6), ACPT(5), ENPP1(12), ENPP3(17), FLAD1(4), LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), PHPT1(1), RFK(1), TYR(12) 5503174 104 33 103 25 17 42 31 0 14 0 0.195 1.000 1.000 214 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), APEX1(1), CREBBP(32), DFFB(4), GZMA(6), GZMB(4), HMGB2(4), NME1(2), PRF1(8), SET(7) 3880986 70 34 66 21 23 23 10 0 13 1 0.301 1.000 1.000 215 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IL2(2), IL2RA(4), IL2RB(3), IL2RG(11), JAK1(20), JAK3(10), JUN(1), LCK(4), MAP2K1(2), MAPK3(3), MAPK8(11), RAF1(9), SHC1(6), SOS1(13), STAT5A(5), STAT5B(7), SYK(4) 8425585 134 54 128 31 32 53 26 2 21 0 0.0221 1.000 1.000 216 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(7), CDO1(4), CSAD(5), GAD1(6), GAD2(12), GGT1(5) 2063029 39 21 39 13 8 12 10 2 7 0 0.508 1.000 1.000 217 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(6), IL1B(2), MST1R(12) 2135450 20 15 18 8 9 7 1 0 3 0 0.694 1.000 1.000 218 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(5), CREM(5), FOS(3), JUN(1), MAPK3(3), OPRK1(10), POLR2A(21), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3) 4652266 75 34 73 22 30 19 14 1 10 1 0.156 1.000 1.000 219 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(6), DCN(11), FMOD(5), KERA(10), LUM(12) 1337449 44 19 40 14 14 17 7 0 6 0 0.411 1.000 1.000 220 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(4), AKT2(6), AKT3(11), BCL2L1(4), CBL(12), CBLB(12), CBLC(5), CCND1(14), CCND2(9), CCND3(4), CISH(2), CLCF1(1), CNTF(3), CNTFR(4), CREBBP(32), CRLF2(5), CSF2(1), CSF2RA(10), CSF2RB(14), CSF3(1), CSF3R(7), EP300(32), EPO(3), EPOR(4), GH1(2), GH2(1), GHR(8), GRB2(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(10), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(3), IL10(4), IL10RA(4), IL10RB(6), IL11(2), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL13RA1(11), IL13RA2(7), IL15(2), IL19(2), IL2(2), IL20(9), IL20RA(4), IL21(3), IL21R(7), IL22RA1(4), IL22RA2(1), IL23A(4), IL23R(5), IL24(5), IL26(3), IL2RA(4), IL2RB(3), IL2RG(11), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL6ST(11), IL7(1), IL7R(12), IL9(1), IL9R(3), IRF9(4), JAK1(20), JAK2(17), JAK3(10), LEP(2), LEPR(12), LIF(3), LIFR(27), MPL(7), MYC(8), OSM(2), OSMR(13), PIAS1(7), PIAS2(14), PIAS3(9), PIAS4(5), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIM1(3), PRL(9), PRLR(5), PTPN11(8), PTPN6(5), SOCS2(6), SOCS4(5), SOCS5(12), SOCS7(5), SOS1(13), SOS2(17), SPRED1(3), SPRED2(8), SPRY1(3), SPRY2(5), SPRY3(6), SPRY4(2), STAM(7), STAM2(5), STAT1(15), STAT2(8), STAT3(11), STAT4(7), STAT5A(5), STAT5B(7), STAT6(10), TPO(14), TSLP(2), TYK2(10) 52598979 1222 219 1078 275 274 415 282 11 216 24 3.71e-07 1.000 1.000 221 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 14 CHUK(8), MAPK14(4), MAPK8(11), NFKB1(10), RELA(6), TNFRSF13B(3), TNFRSF17(1), TNFSF13(3), TNFSF13B(5), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(7) 5225351 73 34 72 17 19 25 11 1 17 0 0.121 1.000 1.000 222 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(5), CDKN1A(1), EPO(3), EPOR(4), GRIN1(4), HIF1A(16), JAK2(17), NFKB1(10), NFKBIA(3), RELA(6), SOD2(3) 4546138 72 30 72 20 16 26 15 1 11 3 0.306 1.000 1.000 223 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(7), BCAT2(3), COASY(11), DPYD(20), DPYS(6), ENPP1(12), ENPP3(17), ILVBL(8), PANK1(3), PANK2(7), PANK3(5), PANK4(5), PPCDC(1), PPCS(4), UPB1(10), VNN1(9) 6157106 128 43 124 32 38 47 30 0 13 0 0.0580 1.000 1.000 224 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(3), ARFGAP1(2), ARFGAP3(4), ARFGEF2(27), CLTB(6), COPA(18), GBF1(15), GPLD1(12), KDELR1(3), KDELR3(3) 5936033 93 39 91 26 34 29 17 0 12 1 0.211 1.000 1.000 225 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(21), CREM(5), FHL5(7), FSHR(15), GNAS(24), XPO1(18) 3289447 90 29 84 21 38 25 15 0 11 1 0.153 1.000 1.000 226 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(8), DUSP1(2), IKBKAP(13), IKBKB(13), IKBKG(3), MAP3K1(30), NFKB1(10), NFKBIA(3), RELA(6), TNFAIP3(3), TRAF3(5), TRAF6(7) 6780716 103 37 102 24 23 41 16 0 22 1 0.140 1.000 1.000 227 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(31), CPT1A(9), LEP(2), LEPR(12), PRKAA1(8), PRKAA2(11), PRKAB1(6), PRKAB2(1), PRKAG1(3), PRKAG2(4) 5343713 87 34 84 24 22 32 14 2 16 1 0.343 1.000 1.000 228 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(7), IFNB1(3), JAK1(20), PTPRU(17), REG1A(4), STAT1(15), STAT2(8), TYK2(10) 4502550 84 34 83 25 33 22 19 0 10 0 0.256 1.000 1.000 229 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), DCXR(1), GUSB(5), RPE(5), UCHL1(4), UGDH(2), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2B15(9), UGT2B4(11) 6412129 83 30 81 19 20 40 11 1 11 0 0.0840 1.000 1.000 230 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(8), APOBEC1(7), APOBEC2(4), APOBEC3A(1), APOBEC3B(5), APOBEC3C(4), APOBEC3F(6), APOBEC3G(3), APOBEC4(5) 2713493 43 20 43 12 15 18 8 1 1 0 0.375 1.000 1.000 231 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(3), TGDS(4), UGDH(2), UXS1(5) 1484004 14 11 14 7 3 6 4 0 1 0 0.907 1.000 1.000 232 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(8), ACTB(3), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(3), CDH1(14), CLDN1(3), CTNNB1(80), CTTN(3), EZR(4), FYN(5), HCLS1(11), ITGB1(8), KRT18(1), LY96(4), NCK1(4), NCK2(8), NCL(7), OCLN(2), PRKCA(11), RHOA(3), ROCK1(22), ROCK2(17), TLR4(17), TLR5(14), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(10), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4), WAS(11), WASL(8), YWHAQ(1), YWHAZ(1) 18662298 374 127 316 99 92 169 66 4 40 3 0.00749 1.000 1.000 233 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(8), ACTB(3), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(3), CDH1(14), CLDN1(3), CTNNB1(80), CTTN(3), EZR(4), FYN(5), HCLS1(11), ITGB1(8), KRT18(1), LY96(4), NCK1(4), NCK2(8), NCL(7), OCLN(2), PRKCA(11), RHOA(3), ROCK1(22), ROCK2(17), TLR4(17), TLR5(14), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(10), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4), WAS(11), WASL(8), YWHAQ(1), YWHAZ(1) 18662298 374 127 316 99 92 169 66 4 40 3 0.00749 1.000 1.000 234 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(12), EIF2AK4(7), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF5(3), GSK3B(13), PPP1CA(2) 4163661 59 28 56 14 17 19 5 3 15 0 0.297 1.000 1.000 235 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(7), BCAT2(3), IARS(8), IARS2(20), ILVBL(8), LARS(18), LARS2(8), PDHA1(7), PDHA2(9), PDHB(3), VARS(6), VARS2(1) 5974162 98 33 95 25 30 36 15 0 17 0 0.242 1.000 1.000 236 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(56), AXIN1(9), CREBBP(32), CTNNB1(80), DVL1(3), EP300(32), FZD1(3), GSK3B(13), HDAC1(5), LDB1(5), LEF1(8), PITX2(8), TRRAP(41), WNT1(1) 11871781 296 124 232 78 62 130 50 5 44 5 0.0471 1.000 1.000 237 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ESCO1(16), ESCO2(8), NAT6(1), PNPLA3(7), SH3GLB1(7) 6018126 55 26 55 12 16 24 7 0 8 0 0.133 1.000 1.000 238 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(8), ACADM(9), ACADS(3), ACADVL(9), ACSL1(13), ACSL3(7), ACSL4(21), CPT1A(9), CPT2(4), EHHADH(10), HADHA(5), PECR(6), SCP2(10), SLC25A20(4) 6111523 118 36 114 30 28 42 26 0 22 0 0.107 1.000 1.000 239 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(4), EGFR(12), IGF1R(13), MYC(8), POLR2A(21), PPP2CA(6), PRKCA(11), RB1(26), TEP1(13), TERF1(1), TERT(4), TNKS(15), TP53(74), XRCC5(8) 10199390 216 106 189 57 79 53 39 3 39 3 0.0284 1.000 1.000 240 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), HEMK1(2), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(4), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), WBSCR22(2) 5308040 80 32 79 24 21 34 8 1 16 0 0.239 1.000 1.000 241 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(54), CCNA1(5), CCNB1(8), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNG2(2), CCNH(7), CDC25A(8), CDK2(2), CDK4(2), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(1), CDKN2C(4), CDKN2D(1), CREB3L1(3), CREB3L3(7), CREB3L4(6), E2F1(9), E2F2(3), E2F3(4), E2F4(3), E2F5(5), E2F6(1), GBA2(9), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(5), MYC(8), MYT1(18), NACA(20), PCNA(3), POLA2(3), POLE(47), POLE2(4), PRIM1(3), RB1(26), RBL1(13), RPA1(6), RPA2(3), RPA3(3), TFDP1(13), TFDP2(6), TNXB(19), TP53(74), WEE1(2) 27079694 523 146 475 124 144 185 99 3 85 7 0.00144 1.000 1.000 242 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(6), CSF1(6), CSF2(1), CSF3(1), HLA-DRA(1), IFNA1(2), IFNB1(3), IFNG(10), IL10(4), IL11(2), IL12A(5), IL12B(2), IL15(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL7(1), LTA(3), PDGFA(3), TGFB1(1), TGFB2(5), TGFB3(9) 4650214 79 42 78 26 22 35 10 1 11 0 0.383 1.000 1.000 243 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(6), ACAT2(4), ACOT11(5), ACYP1(2), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ECHS1(3), EHHADH(10), ESCO1(16), ESCO2(8), FN3K(5), GCDH(4), HADHA(5), NAT6(1), PNPLA3(7), SH3GLB1(7), YOD1(2) 9402046 101 41 101 27 25 42 19 0 15 0 0.219 1.000 1.000 244 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(6), ADCY3(12), ADCY9(27), AK1(1), ARF1(3), ARF3(4), ARF4(3), ARF5(4), ARF6(3), ARL4D(1), ATP6V0A1(8), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), ERO1L(6), GNAS(24), PDIA4(5), PLCG1(12), PLCG2(27), PRKCA(11), SEC61A1(5), SEC61A2(3), SEC61B(2), SEC61G(3), TRIM23(11) 13444408 271 65 264 62 92 88 47 2 38 4 0.00106 1.000 1.000 245 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(4), ANXA2(4), ANXA3(3), ANXA4(10), ANXA5(3), ANXA6(12), CYP11A1(9), EDN1(4), EDNRA(5), EDNRB(4), HPGD(6), HSD11B1(6), PLA2G4A(13), PRL(9), PTGDR(9), PTGDS(4), PTGER2(3), PTGER4(12), PTGFR(10), PTGIR(3), PTGIS(7), PTGS1(5), PTGS2(9), SCGB1A1(2), TBXAS1(7) 7412477 163 49 161 36 45 61 28 2 27 0 0.00484 1.000 1.000 246 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(3), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), ST3GAL5(4), ST6GALNAC2(4), ST6GALNAC4(4), ST8SIA1(2) 1942787 28 21 27 10 12 11 4 0 1 0 0.445 1.000 1.000 247 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), ALDH1A3(8), ALDH3A1(4), ALDH3B2(7), AOC2(7), AOC3(10), AOX1(18), COMT(3), DBH(9), DCT(11), DDC(8), FAH(6), GOT1(9), GOT2(3), GSTZ1(5), HGD(4), HPD(2), MAOA(12), MAOB(7), PNMT(2), TAT(7), TH(3), TPO(14), TYR(12) 11116639 200 56 196 54 62 65 44 2 27 0 0.0253 1.000 1.000 248 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CD14(2), CHUK(8), ELK1(3), FOS(3), IKBKB(13), IKBKG(3), IRAK1(4), JUN(1), LY96(4), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K7(9), MAPK14(4), MAPK8(11), MYD88(2), NFKB1(10), NFKBIA(3), PPARA(2), RELA(6), TIRAP(2), TLR10(19), TLR2(16), TLR3(10), TLR4(17), TLR6(14), TLR7(17), TLR9(6), TOLLIP(1), TRAF6(7) 13189970 253 65 250 57 54 99 52 0 45 3 0.00649 1.000 1.000 249 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(10), CPEB1(9), EGFR(12), ERBB2(10), ERBB4(27), ETS1(6), ETS2(6), ETV6(6), ETV7(4), FMN2(27), GRB2(3), KRAS(52), MAP2K1(2), MAPK1(2), MAPK3(3), NOTCH1(10), NOTCH2(18), NOTCH3(29), NOTCH4(9), PIWIL1(21), PIWIL2(14), PIWIL3(10), PIWIL4(14), RAF1(9), SOS1(13), SOS2(17), SPIRE1(9), SPIRE2(4) 17642222 356 110 303 81 87 161 61 6 39 2 0.00118 1.000 1.000 250 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(21), COL4A2(14), COL4A3(25), COL4A4(23), COL4A5(26), COL4A6(31), F10(12), F11(15), F12(2), F2(8), F2R(6), F5(47), F8(45), F9(14), FGA(26), FGB(7), FGG(9), KLKB1(10), PROC(4), PROS1(21), SERPINC1(10), SERPING1(7) 16412302 383 70 365 94 84 177 65 2 49 6 0.0124 1.000 1.000 251 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(21), COL4A2(14), COL4A3(25), COL4A4(23), COL4A5(26), COL4A6(31), P4HB(5), SLC23A1(6), SLC23A2(7), SLC2A1(2), SLC2A3(8) 9449324 168 48 163 49 40 79 21 2 22 4 0.117 1.000 1.000 252 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(8), CTH(6), GOT1(9), GOT2(3), LDHA(6), LDHB(3), LDHC(5), MPST(1) 2443982 41 26 40 13 6 17 10 1 7 0 0.647 1.000 1.000 253 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(5), GRB2(3), HRAS(1), PTK2B(15), SHC1(6), SOS1(13), SRC(3) 3131844 46 31 43 14 14 20 10 0 2 0 0.467 1.000 1.000 254 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(22), C5(18), C6(16), C7(20), ICAM1(2), IL6(5), ITGA4(10), ITGAL(17), ITGB1(8), ITGB2(15), SELP(13), SELPLG(9), VCAM1(12) 9034468 167 51 160 44 40 71 25 0 29 2 0.0372 1.000 1.000 255 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(5), ACAD9(8), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ESCO1(16), ESCO2(8), NAT6(1), PNPLA3(7), SH3GLB1(7) 9147786 97 33 97 24 31 34 15 0 16 1 0.102 1.000 1.000 256 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(6), CSF1R(8), DDX20(4), E2F1(9), E2F4(3), ETS1(6), ETS2(6), ETV3(9), FOS(3), HDAC2(3), HDAC5(12), HRAS(1), JUN(1), NCOR2(24), RBL1(13), RBL2(19), SIN3A(29), SIN3B(13) 9425937 169 58 162 42 58 47 30 0 33 1 0.0246 1.000 1.000 257 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(9), ACTN2(16), BCAR1(8), CSK(1), CTNNA1(17), CTNNA2(16), CTNNB1(80), PTK2(12), PXN(6), SRC(3), VCL(11) 6836403 179 99 120 47 36 91 30 2 18 2 0.0621 1.000 1.000 258 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(12), EGF(19), EGFR(12), GRB2(3), HRAS(1), MAP2K1(2), MAPK1(2), MAPK3(3), PTPRB(28), RAF1(9), RASA1(29), SHC1(6), SOS1(13), SPRY1(3), SPRY2(5), SPRY3(6), SPRY4(2), SRC(3) 9178228 158 59 151 36 39 57 35 0 26 1 0.0483 1.000 1.000 259 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(11), IL13RA2(7), IL4R(6), JAK1(20), JAK2(17), TYK2(10) 3765029 71 32 71 23 14 24 18 1 11 3 0.573 1.000 1.000 260 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(11), IL13RA2(7), IL4R(6), JAK1(20), JAK2(17), TYK2(10) 3765029 71 32 71 23 14 24 18 1 11 3 0.573 1.000 1.000 261 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(19), CAPN1(5), CAPNS1(2), CAPNS2(3), CDK5(2), CDK5R1(3), CSNK1A1(3), CSNK1D(3), GSK3B(13), MAPT(9), PPP2CA(6) 3361556 68 29 67 22 31 19 9 0 9 0 0.317 1.000 1.000 262 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(17), EGF(19), EGFR(12), HGS(8), RAB5A(2), TF(13), TFRC(4) 4655220 75 27 73 25 20 28 15 0 12 0 0.570 1.000 1.000 263 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(52), MAP2(31), PPP1CA(2), PPP2CA(6), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAR2A(4), PRKAR2B(3), PRKCE(10) 6652974 123 39 120 30 24 47 28 0 21 3 0.209 1.000 1.000 264 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(8), ALOX15(9), ALOX15B(6), ALOX5(10), ALOX5AP(3), DPEP1(3), GGT1(5), LTA4H(4), PLA2G6(9), PTGDS(4), PTGES(2), PTGIS(7), PTGS1(5), PTGS2(9), TBXAS1(7) 5401004 91 33 89 27 39 27 16 1 8 0 0.149 1.000 1.000 265 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), DCXR(1), GUSB(5), RPE(5), UGDH(2), UGP2(6), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2A1(9), UGT2A3(5), UGT2B10(18), UGT2B11(8), UGT2B15(9), UGT2B17(7), UGT2B28(15), UGT2B4(11), UGT2B7(5), XYLB(5) 9582049 157 37 149 32 31 73 29 1 23 0 0.0133 1.000 1.000 266 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(3), CAMK1G(5), HDAC9(15), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), YWHAH(3) 2977293 47 18 46 16 16 13 10 0 7 1 0.486 1.000 1.000 267 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(8), IFNA1(2), IFNB1(3), IKBKB(13), IL1B(2), IL1R1(5), IL1RAP(8), IL6(5), IRAK1(4), IRAK2(9), IRAK3(10), JUN(1), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAP3K7(9), MAPK14(4), MAPK8(11), MYD88(2), NFKB1(10), NFKBIA(3), RELA(6), TGFB1(1), TGFB2(5), TGFB3(9), TOLLIP(1), TRAF6(7) 10714977 185 54 181 41 39 75 35 0 35 1 0.0312 1.000 1.000 268 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(4), ATF2(8), CDC42(3), DLD(5), DUSP10(5), DUSP8(1), GAB1(7), GCK(2), IL1R1(5), JUN(1), MAP2K4(9), MAP2K5(3), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K11(5), MAP3K12(6), MAP3K13(13), MAP3K2(12), MAP3K3(8), MAP3K4(21), MAP3K5(25), MAP3K7(9), MAP3K9(6), MAPK10(10), MAPK7(14), MAPK8(11), MAPK9(4), MYEF2(7), NFATC3(11), NR2C2(7), PAPPA(27), SHC1(6), TP53(74), TRAF6(7), ZAK(14) 17971185 391 123 363 95 124 130 65 4 66 2 0.0160 1.000 1.000 269 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(27), EEF1A2(4), EEF1B2(3), EEF1D(6), EEF1G(5), EEF2(13), EEF2K(11), EIF1AX(4), EIF2AK1(8), EIF2AK2(13), EIF2AK3(12), EIF2B2(5), EIF2B3(7), EIF2B4(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF4A1(5), EIF4A2(8), EIF4E(1), EIF4EBP2(1), EIF4G1(16), EIF4G3(23), EIF5(3), EIF5A(4), EIF5B(15), ETF1(7), GSPT2(18), PABPC1(10), PABPC3(8), PAIP1(7), SLC35A4(5) 15890643 275 71 268 57 81 99 44 6 42 3 0.000814 1.000 1.000 270 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN4(8), AKT1(4), AKT2(6), AKT3(11), ARHGAP5(21), BAD(1), BCAR1(8), BIRC2(10), BIRC3(5), BRAF(10), CAPN2(11), CAV1(2), CAV2(1), CCND1(14), CCND2(9), CCND3(4), CDC42(3), CHAD(3), COL11A1(35), COL11A2(10), COL1A1(12), COL1A2(24), COL2A1(16), COL3A1(18), COL4A1(21), COL4A2(14), COL4A4(23), COL4A6(31), COL5A1(30), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(12), COL6A3(44), COL6A6(27), COMP(7), CRK(2), CRKL(6), CTNNB1(80), DIAPH1(12), DOCK1(21), EGF(19), EGFR(12), ELK1(3), ERBB2(10), FARP2(14), FIGF(5), FLNA(38), FLNB(33), FLNC(37), FLT1(20), FN1(42), FYN(5), GRB2(3), GSK3B(13), HGF(14), HRAS(1), IBSP(7), IGF1(5), IGF1R(13), ILK(5), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(11), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(19), ITGA9(16), ITGAV(10), ITGB1(8), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), JUN(1), KDR(26), LAMA1(31), LAMA2(61), LAMA3(29), LAMA4(16), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(15), LAMB4(30), LAMC1(18), LAMC2(17), LAMC3(17), MAP2K1(2), MAPK1(2), MAPK10(10), MAPK3(3), MAPK8(11), MAPK9(4), MET(17), MYL2(2), MYL5(1), MYL7(1), MYL9(3), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PARVA(4), PARVB(4), PARVG(7), PDGFA(3), PDGFB(2), PDGFC(3), PDGFD(8), PDGFRA(24), PDGFRB(12), PDPK1(3), PGF(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP5K1C(6), PPP1CA(2), PPP1CB(9), PPP1CC(2), PPP1R12A(8), PRKCA(11), PRKCG(8), PTEN(227), PTK2(12), PXN(6), RAC1(1), RAC2(2), RAF1(9), RAP1A(4), RAP1B(2), RAPGEF1(10), RELN(48), RHOA(3), ROCK1(22), ROCK2(17), SHC1(6), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SPP1(2), SRC(3), THBS1(10), THBS2(20), THBS3(3), THBS4(12), TLN1(23), TLN2(29), TNC(26), TNN(19), TNR(14), TNXB(19), VASP(3), VAV1(12), VAV2(7), VAV3(13), VCL(11), VEGFA(2), VEGFB(3), VEGFC(6), VTN(3), VWF(25), ZYX(11) 132352116 2775 237 2453 741 705 958 487 58 499 68 3.19e-08 1.000 1.000 271 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(4), ACTN1(9), ACTN2(16), ACTN4(8), APC(56), ARAF(12), ARHGEF1(12), ARHGEF12(28), ARHGEF4(8), ARHGEF6(25), ARHGEF7(15), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(5), BCAR1(8), BDKRB1(3), BDKRB2(8), BRAF(10), CD14(2), CDC42(3), CFL1(1), CFL2(8), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CRK(2), CRKL(6), CSK(1), CYFIP1(8), CYFIP2(18), DIAPH1(12), DIAPH2(31), DIAPH3(25), DOCK1(21), EGF(19), EGFR(12), EZR(4), F2(8), F2R(6), FGD1(15), FGD3(9), FGF10(2), FGF11(1), FGF12(5), FGF13(4), FGF14(4), FGF16(1), FGF17(1), FGF18(1), FGF21(1), FGF23(3), FGF3(1), FGF5(9), FGF6(3), FGF7(5), FGF8(3), FGF9(1), FGFR1(9), FGFR2(33), FGFR3(3), FGFR4(11), FN1(42), GIT1(9), GNA12(7), GNA13(7), GNG12(1), GSN(4), HRAS(1), INS(1), IQGAP1(12), IQGAP2(24), IQGAP3(16), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(11), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(19), ITGA9(16), ITGAD(11), ITGAE(9), ITGAL(17), ITGAM(21), ITGAV(10), ITGAX(14), ITGB1(8), ITGB2(15), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), KRAS(52), LIMK1(8), LIMK2(13), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MOS(6), MRAS(2), MSN(18), MYH10(29), MYH14(21), MYH9(23), MYL2(2), MYL5(1), MYL7(1), MYL9(3), MYLK(14), MYLK2(8), NCKAP1(8), NCKAP1L(19), NRAS(9), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PDGFA(3), PDGFB(2), PDGFRA(24), PDGFRB(12), PFN1(1), PFN2(2), PFN4(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(6), PPP1CA(2), PPP1CB(9), PPP1CC(2), PPP1R12A(8), PPP1R12B(19), PTK2(12), PXN(6), RAC1(1), RAC2(2), RAF1(9), RDX(17), RHOA(3), ROCK1(22), ROCK2(17), RRAS(3), RRAS2(4), SCIN(6), SLC9A1(7), SOS1(13), SOS2(17), SSH1(15), SSH2(13), SSH3(4), TIAM1(27), TIAM2(14), VAV1(12), VAV2(7), VAV3(13), VCL(11), WAS(11), WASF1(3), WASF2(3), WASL(8) 100375796 2053 224 1825 575 542 726 389 25 336 35 0.000136 1.000 1.000 272 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN1(9), ACTN2(16), ACTN4(8), ARHGAP5(21), BCAR1(8), CDC42(3), CDH5(6), CLDN1(3), CLDN10(7), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CTNNA1(17), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTNND1(27), CXCL12(3), CXCR4(1), CYBA(2), CYBB(9), ESAM(1), EZR(4), F11R(1), GNAI1(5), GNAI2(6), GNAI3(4), ICAM1(2), ITGA4(10), ITGAL(17), ITGAM(21), ITGB1(8), ITGB2(15), ITK(7), JAM2(9), JAM3(2), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MLLT4(21), MMP2(7), MMP9(12), MSN(18), MYL2(2), MYL5(1), MYL7(1), MYL9(3), NCF1(2), NCF2(8), NCF4(5), NOX1(16), NOX3(7), OCLN(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(27), PRKCA(11), PRKCG(8), PTK2(12), PTK2B(15), PTPN11(8), PXN(6), RAC1(1), RAC2(2), RAP1A(4), RAP1B(2), RAPGEF3(8), RAPGEF4(15), RASSF5(3), RHOA(3), RHOH(1), ROCK1(22), ROCK2(17), SIPA1(1), THY1(1), TXK(6), VASP(3), VAV1(12), VAV2(7), VAV3(13), VCAM1(12), VCL(11) 44542115 1110 221 922 278 269 387 228 12 193 21 0.000244 1.000 1.000 273 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(31), ACACB(29), AKT1(4), AKT2(6), AKT3(11), ARAF(12), BAD(1), BRAF(10), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CBL(12), CBLB(12), CBLC(5), CRK(2), CRKL(6), ELK1(3), EXOC7(4), FASN(9), FBP1(2), FBP2(1), FLOT1(1), FLOT2(2), FOXO1(12), G6PC(5), G6PC2(11), GCK(2), GRB2(3), GSK3B(13), GYS1(13), GYS2(16), HRAS(1), IKBKB(13), INPP5D(9), INS(1), INSR(18), IRS1(13), IRS4(20), KRAS(52), LIPE(13), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK10(10), MAPK3(3), MAPK8(11), MAPK9(4), MKNK1(3), MKNK2(2), NRAS(9), PCK1(9), PCK2(7), PDE3A(19), PDE3B(15), PDPK1(3), PFKL(8), PFKM(8), PFKP(8), PHKA1(20), PHKA2(21), PHKB(13), PHKG1(7), PHKG2(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PKLR(6), PPARGC1A(9), PPP1CA(2), PPP1CB(9), PPP1CC(2), PPP1R3A(32), PPP1R3B(2), PPP1R3C(4), PRKAA1(8), PRKAA2(11), PRKAB1(6), PRKAB2(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAG2(4), PRKAG3(6), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCI(6), PRKCZ(2), PRKX(2), PTPN1(5), PTPRF(26), PYGB(11), PYGL(8), PYGM(10), RAF1(9), RAPGEF1(10), RHEB(3), RHOQ(1), RPS6(7), RPS6KB1(3), RPS6KB2(4), SH2B2(1), SHC1(6), SHC2(5), SHC3(15), SHC4(5), SLC2A4(9), SOCS2(6), SOCS4(5), SORBS1(18), SOS1(13), SOS2(17), SREBF1(2), TRIP10(10), TSC1(12), TSC2(14) 56199251 1314 221 1121 331 370 428 260 14 222 20 3.25e-06 1.000 1.000 274 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(56), AXIN1(9), AXIN2(9), BTRC(14), CACYBP(2), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CCND1(14), CCND2(9), CCND3(4), CER1(4), CHD8(34), CREBBP(32), CSNK1A1(3), CSNK1A1L(4), CSNK1E(3), CSNK2A1(9), CSNK2A2(4), CTBP1(1), CTBP2(3), CTNNB1(80), CUL1(13), CXXC4(1), DAAM1(18), DAAM2(10), DKK1(3), DKK2(3), DKK4(3), DVL1(3), DVL2(10), DVL3(9), EP300(32), FBXW11(5), FOSL1(3), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD4(4), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GSK3B(13), JUN(1), LEF1(8), LRP5(14), LRP6(26), MAP3K7(9), MAPK10(10), MAPK8(11), MAPK9(4), MYC(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NKD1(3), NLK(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PORCN(9), PPARD(3), PPP2CA(6), PPP2CB(4), PPP2R1A(31), PPP2R1B(5), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRICKLE1(6), PRICKLE2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKX(2), PSEN1(5), RAC1(1), RAC2(2), RBX1(1), RHOA(3), ROCK1(22), ROCK2(17), RUVBL1(2), SENP2(11), SFRP1(6), SFRP2(4), SFRP4(9), SFRP5(2), SIAH1(6), SMAD2(9), SMAD3(7), SMAD4(5), SOX17(7), TBL1X(8), TBL1XR1(16), TCF7(3), TCF7L1(4), TCF7L2(11), TP53(74), VANGL1(6), VANGL2(10), WIF1(5), WNT1(1), WNT10A(2), WNT10B(1), WNT11(5), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT3A(1), WNT4(1), WNT5A(6), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2) 56493350 1161 217 1041 307 370 404 213 10 157 7 1.39e-05 1.000 1.000 275 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN4(8), AKT1(4), AKT2(6), AKT3(11), AMOTL1(12), ASH1L(42), CASK(17), CDC42(3), CDK4(2), CGN(14), CLDN1(3), CLDN10(7), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CSNK2A1(9), CSNK2A2(4), CTNNA1(17), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTTN(3), EPB41(11), EPB41L1(15), EPB41L2(14), EPB41L3(17), EXOC3(8), EXOC4(6), F11R(1), GNAI1(5), GNAI2(6), GNAI3(4), HCLS1(11), HRAS(1), IGSF5(5), INADL(21), JAM2(9), JAM3(2), KRAS(52), LLGL1(10), LLGL2(6), MAGI1(22), MAGI2(28), MAGI3(16), MLLT4(21), MPDZ(21), MPP5(10), MRAS(2), MYH1(43), MYH10(29), MYH11(30), MYH13(22), MYH14(21), MYH15(23), MYH2(41), MYH3(31), MYH4(30), MYH6(16), MYH7(35), MYH7B(14), MYH8(29), MYH9(23), MYL2(2), MYL5(1), MYL7(1), MYL9(3), NRAS(9), OCLN(2), PARD3(19), PARD6B(3), PARD6G(1), PPM1J(3), PPP2CA(6), PPP2CB(4), PPP2R1A(31), PPP2R1B(5), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PPP2R3A(10), PPP2R3B(9), PPP2R4(3), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(2), PTEN(227), RAB13(3), RAB3B(2), RHOA(3), RRAS(3), RRAS2(4), SPTAN1(31), SRC(3), SYMPK(16), TJAP1(6), TJP1(24), TJP2(16), TJP3(6), VAPA(5), YES1(8), ZAK(14) 70594305 1623 216 1382 443 420 555 266 53 285 44 0.00137 1.000 1.000 276 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1B(8), ACVR1C(6), AKT1(4), AKT2(6), AKT3(11), ARRB1(4), ARRB2(5), ATF2(8), ATF4(3), BDNF(7), BRAF(10), CACNA1A(19), CACNA1B(31), CACNA1C(38), CACNA1D(28), CACNA1E(58), CACNA1F(38), CACNA1G(23), CACNA1H(12), CACNA1I(8), CACNA1S(34), CACNA2D1(15), CACNA2D2(11), CACNA2D3(22), CACNA2D4(16), CACNB1(11), CACNB2(13), CACNB3(5), CACNB4(13), CACNG1(1), CACNG2(4), CACNG3(10), CACNG4(6), CACNG5(3), CACNG6(4), CACNG7(7), CACNG8(1), CASP3(4), CD14(2), CDC25B(3), CDC42(3), CHUK(8), CRK(2), CRKL(6), DAXX(9), DDIT3(2), DUSP1(2), DUSP10(5), DUSP14(4), DUSP16(11), DUSP3(2), DUSP5(4), DUSP6(2), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(5), EGF(19), EGFR(12), ELK1(3), ELK4(3), FAS(8), FASLG(7), FGF10(2), FGF11(1), FGF12(5), FGF13(4), FGF14(4), FGF16(1), FGF17(1), FGF18(1), FGF21(1), FGF23(3), FGF3(1), FGF5(9), FGF6(3), FGF7(5), FGF8(3), FGF9(1), FGFR1(9), FGFR2(33), FGFR3(3), FGFR4(11), FLNA(38), FLNB(33), FLNC(37), FOS(3), GADD45G(1), GNA12(7), GNG12(1), GRB2(3), HRAS(1), IKBKB(13), IKBKG(3), IL1B(2), IL1R1(5), IL1R2(5), JUN(1), KRAS(52), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K5(3), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K12(6), MAP3K13(13), MAP3K2(12), MAP3K3(8), MAP3K4(21), MAP3K5(25), MAP3K6(7), MAP3K7(9), MAP3K8(10), MAP4K1(12), MAP4K2(5), MAP4K3(16), MAP4K4(10), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK7(14), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(5), MAPT(9), MAX(9), MEF2C(10), MKNK1(3), MKNK2(2), MOS(6), MRAS(2), MYC(8), NF1(35), NFATC2(13), NFATC4(5), NFKB1(10), NFKB2(9), NLK(5), NR4A1(6), NRAS(9), NTF3(5), NTRK1(13), NTRK2(13), PAK1(3), PAK2(3), PDGFA(3), PDGFB(2), PDGFRA(24), PDGFRB(12), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PPM1A(5), PPM1B(3), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PPP5C(7), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKX(2), PTPN5(8), PTPN7(6), PTPRR(17), RAC1(1), RAC2(2), RAF1(9), RAP1A(4), RAP1B(2), RAPGEF2(31), RASA1(29), RASA2(11), RASGRF1(11), RASGRF2(18), RASGRP1(8), RASGRP2(4), RASGRP3(11), RASGRP4(6), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA4(2), RPS6KA5(11), RPS6KA6(19), RRAS(3), RRAS2(4), SOS1(13), SOS2(17), SRF(3), STK3(12), STK4(9), STMN1(4), TAOK1(12), TAOK2(8), TAOK3(5), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6), TNFRSF1A(4), TP53(74), TRAF2(3), TRAF6(7), ZAK(14) 104048776 2054 201 1923 623 633 723 350 28 303 17 0.000141 1.000 1.000 277 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(8), ACVR1B(8), ACVRL1(2), AKT1(4), AURKB(4), BMPR1A(5), BMPR2(12), BUB1(10), CDKL1(4), CDKL2(5), CDS1(5), CLK1(7), CLK2(8), CLK4(7), COL4A3BP(3), CSNK2A1(9), CSNK2A2(4), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKQ(2), DGKZ(10), IMPA1(3), INPP1(3), INPP4A(19), INPP4B(16), INPP5A(4), INPPL1(18), ITPKA(1), ITPKB(11), MAP3K10(7), MOS(6), NEK1(19), NEK3(7), OCRL(19), PIK3C2A(22), PIK3C2B(10), PIK3C2G(16), PIK3CA(172), PIK3CB(17), PIK3CG(23), PIM2(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(4), PLCG1(12), PLCG2(27), PLK3(8), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), PRKCZ(2), PRKD1(8), PRKG1(11), RAF1(9), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA4(2), RPS6KB1(3), STK11(2), TGFBR1(6), VRK1(12) 41274078 859 185 743 253 243 278 204 10 120 4 0.0972 1.000 1.000 278 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CREB1(5), CREB3L1(3), CREB3L2(4), CREB3L3(7), CREB3L4(6), CREBBP(32), CTNNB1(80), DCT(11), DVL1(3), DVL2(10), DVL3(9), EDN1(4), EDNRB(4), EP300(32), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD4(4), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GNAI1(5), GNAI2(6), GNAI3(4), GNAO1(6), GNAQ(3), GNAS(24), GSK3B(13), HRAS(1), KIT(23), KITLG(3), KRAS(52), LEF1(8), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MC1R(3), MITF(5), NRAS(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), POMC(4), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKX(2), RAF1(9), TCF7(3), TCF7L1(4), TCF7L2(11), TYR(12), TYRP1(7), WNT1(1), WNT10A(2), WNT10B(1), WNT11(5), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT3A(1), WNT4(1), WNT5A(6), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2) 37866316 823 177 706 261 264 297 156 11 93 2 0.0131 1.000 1.000 279 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(8), ANAPC1(21), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(8), ANAPC7(5), ATM(54), ATR(38), BUB1(10), BUB1B(6), BUB3(4), CCNA1(5), CCNA2(7), CCNB1(8), CCNB2(5), CCNB3(33), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNH(7), CDC14A(6), CDC14B(6), CDC16(11), CDC20(4), CDC23(5), CDC25A(8), CDC25B(3), CDC25C(5), CDC6(3), CDC7(11), CDK2(2), CDK4(2), CDK6(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(1), CDKN2C(4), CDKN2D(1), CHEK1(2), CHEK2(13), CREBBP(32), CUL1(13), DBF4(11), E2F1(9), E2F2(3), E2F3(4), EP300(32), ESPL1(12), FZR1(2), GADD45G(1), GSK3B(13), HDAC1(5), HDAC2(3), MAD1L1(12), MAD2L1(3), MAD2L2(2), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(5), PCNA(3), PKMYT1(2), PLK1(4), PRKDC(54), PTTG1(2), RB1(26), RBL1(13), RBL2(19), RBX1(1), SKP2(6), SMAD2(9), SMAD3(7), SMAD4(5), SMC1A(18), SMC1B(19), TFDP1(13), TGFB1(1), TGFB2(5), TGFB3(9), TP53(74), WEE1(2), YWHAE(5), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1) 49263559 892 172 845 221 250 291 175 5 158 13 0.00377 1.000 1.000 280 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY7(9), ADCY8(22), ADCY9(27), ADORA2A(6), ADORA2B(1), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRB2(7), ADRB3(3), AGTR1(4), ATP2A1(13), ATP2A2(8), ATP2A3(11), ATP2B1(15), ATP2B2(12), ATP2B3(16), ATP2B4(14), AVPR1A(7), AVPR1B(3), BDKRB1(3), BDKRB2(8), BST1(1), CACNA1A(19), CACNA1B(31), CACNA1C(38), CACNA1D(28), CACNA1E(58), CACNA1F(38), CACNA1G(23), CACNA1H(12), CACNA1I(8), CACNA1S(34), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CAMK4(5), CCKAR(9), CCKBR(3), CD38(6), CHRM1(6), CHRM2(10), CHRM3(8), CHRM5(9), CHRNA7(5), CYSLTR1(8), CYSLTR2(5), DRD1(6), EDNRA(5), EDNRB(4), EGFR(12), ERBB2(10), ERBB3(19), ERBB4(27), F2R(6), GNA11(2), GNA14(7), GNA15(1), GNAL(6), GNAQ(3), GNAS(24), GRIN1(4), GRIN2A(25), GRIN2C(6), GRIN2D(5), GRM1(26), GRM5(26), GRPR(4), HRH1(10), HRH2(4), HTR2A(11), HTR2B(2), HTR2C(16), HTR4(6), HTR5A(12), HTR6(4), HTR7(5), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), LHCGR(17), LTB4R2(4), MYLK(14), MYLK2(8), NOS1(18), NOS3(11), NTSR1(5), OXTR(4), P2RX1(5), P2RX2(3), P2RX3(8), P2RX4(1), P2RX5(5), P2RX7(1), PDE1A(14), PDE1B(7), PDE1C(11), PDGFRA(24), PDGFRB(12), PHKA1(20), PHKA2(21), PHKB(13), PHKG1(7), PHKG2(3), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(4), PLCD3(3), PLCD4(10), PLCE1(39), PLCG1(12), PLCG2(27), PLCZ1(13), PLN(2), PPID(2), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKX(2), PTAFR(4), PTGER3(4), PTGFR(10), PTK2B(15), RYR1(73), RYR2(109), RYR3(93), SLC25A4(2), SLC25A5(2), SLC25A6(5), SLC8A1(13), SLC8A2(6), SLC8A3(13), SPHK1(2), SPHK2(2), TACR1(7), TACR2(3), TACR3(9), TNNC1(2), TNNC2(3), TRHR(3), TRPC1(13), VDAC1(2), VDAC2(3), VDAC3(2) 98590383 1919 171 1872 743 653 690 332 15 212 17 0.638 1.000 1.000 281 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(8), ABLIM1(6), ABLIM2(7), ABLIM3(8), ARHGEF12(28), CDC42(3), CDK5(2), CFL1(1), CFL2(8), CXCL12(3), CXCR4(1), DCC(34), DPYSL2(12), DPYSL5(4), EFNA1(1), EFNA3(1), EFNA4(3), EFNA5(3), EFNB1(6), EFNB2(2), EFNB3(1), EPHA1(11), EPHA2(5), EPHA3(18), EPHA4(19), EPHA5(25), EPHA6(20), EPHA7(10), EPHA8(13), EPHB1(26), EPHB2(11), EPHB3(6), EPHB4(4), EPHB6(11), FES(15), FYN(5), GNAI1(5), GNAI2(6), GNAI3(4), GSK3B(13), HRAS(1), ITGB1(8), KRAS(52), L1CAM(20), LIMK1(8), LIMK2(13), LRRC4C(13), MAPK1(2), MAPK3(3), MET(17), NCK1(4), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NGEF(15), NRAS(9), NRP1(13), NTN1(3), NTN4(5), NTNG1(7), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PLXNA1(24), PLXNA2(25), PLXNA3(18), PLXNB1(13), PLXNB2(16), PLXNB3(21), PLXNC1(26), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PTK2(12), RAC1(1), RAC2(2), RASA1(29), RGS3(8), RHOA(3), RHOD(1), RND1(6), ROBO1(23), ROBO2(25), ROBO3(16), ROCK1(22), ROCK2(17), SEMA3A(8), SEMA3C(11), SEMA3D(12), SEMA3E(9), SEMA3F(6), SEMA3G(5), SEMA4A(8), SEMA4B(3), SEMA4C(7), SEMA4D(6), SEMA4F(11), SEMA4G(4), SEMA5A(19), SEMA5B(8), SEMA6A(9), SEMA6B(3), SEMA6C(5), SEMA6D(26), SEMA7A(11), SLIT1(13), SLIT2(28), SLIT3(19), SRGAP1(18), SRGAP2(14), SRGAP3(10), UNC5A(9), UNC5B(8), UNC5C(10), UNC5D(16) 69179806 1301 163 1223 432 405 469 224 9 183 11 0.100 1.000 1.000 282 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 233 ADCYAP1R1(5), ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(4), ADRA1A(12), ADRA1B(6), ADRA2A(6), ADRA2B(5), ADRA2C(2), ADRB2(7), ADRB3(3), AGTR1(4), AGTR2(11), AVPR1A(7), AVPR1B(3), AVPR2(4), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), C5AR1(4), CALCR(9), CALCRL(8), CCKAR(9), CCKBR(3), CGA(1), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CNR1(11), CNR2(6), CRHR1(3), CRHR2(2), CTSG(3), CYSLTR1(8), CYSLTR2(5), DRD1(6), DRD2(8), DRD3(6), DRD5(11), EDNRA(5), EDNRB(4), F2(8), F2R(6), F2RL1(4), F2RL2(2), FPR1(2), FSHR(15), GABBR1(11), GABBR2(15), GABRA1(14), GABRA2(13), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(8), GABRB1(9), GABRB2(15), GABRB3(10), GABRD(6), GABRE(7), GABRG1(10), GABRG2(16), GABRG3(9), GABRP(5), GABRQ(11), GABRR1(3), GALR1(3), GALR3(2), GH1(2), GH2(1), GHR(8), GHRHR(2), GHSR(8), GIPR(5), GLP1R(5), GLP2R(11), GLRA1(8), GLRA2(8), GLRA3(9), GLRB(7), GNRHR(4), GPR156(7), GPR35(3), GPR50(8), GPR63(5), GPR83(3), GRIA1(12), GRIA2(21), GRIA3(21), GRIA4(17), GRID1(12), GRID2(17), GRIK1(17), GRIK2(12), GRIK3(16), GRIK4(7), GRIK5(17), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), GRIN3A(15), GRIN3B(3), GRM1(26), GRM2(9), GRM3(18), GRM4(11), GRM5(26), GRM6(15), GRM7(19), GRM8(19), GRPR(4), GZMA(6), HCRTR2(11), HRH1(10), HRH2(4), HRH3(2), HRH4(5), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(16), HTR4(6), HTR5A(12), HTR6(4), HTR7(5), LEP(2), LEPR(12), LHB(2), LHCGR(17), LTB4R(2), LTB4R2(4), MAS1(3), MC1R(3), MC2R(4), MC3R(5), MC4R(5), MC5R(14), MCHR1(8), MCHR2(3), MLNR(3), MTNR1A(5), MTNR1B(4), NMBR(4), NMUR1(4), NMUR2(8), NPBWR2(1), NPFFR1(1), NPFFR2(13), NPY1R(9), NPY2R(5), NPY5R(13), NR3C1(17), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(11), OXTR(4), P2RX1(5), P2RX2(3), P2RX3(8), P2RX4(1), P2RX5(5), P2RX7(1), P2RY1(3), P2RY10(8), P2RY11(7), P2RY13(2), P2RY14(6), P2RY2(3), P2RY4(5), P2RY6(4), P2RY8(7), PARD3(19), PRL(9), PRLHR(1), PRLR(5), PRSS1(2), PRSS3(2), PTAFR(4), PTGDR(9), PTGER2(3), PTGER3(4), PTGER4(12), PTGFR(10), PTGIR(3), PTH2R(12), RXFP1(21), RXFP2(14), SCTR(5), SSTR1(9), SSTR2(3), SSTR3(3), SSTR4(10), SSTR5(2), TAAR1(7), TAAR2(7), TAAR5(5), TAAR6(6), TAAR8(3), TACR1(7), TACR2(3), TACR3(9), THRA(4), THRB(4), TRHR(3), TRPV1(2), TSHB(3), TSHR(8), TSPO(2), VIPR1(3), VIPR2(4) 77867473 1688 161 1631 650 515 713 274 19 159 8 0.271 1.000 1.000 283 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(3), ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN4(8), ACVR1B(8), ACVR1C(6), BAIAP2(5), CDC42(3), CDH1(14), CREBBP(32), CSNK2A1(9), CSNK2A2(4), CTNNA1(17), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTNND1(27), EGFR(12), EP300(32), ERBB2(10), FARP2(14), FER(14), FGFR1(9), FYN(5), IGF1R(13), INSR(18), IQGAP1(12), LEF1(8), LMO7(26), MAP3K7(9), MAPK1(2), MAPK3(3), MET(17), MLLT4(21), NLK(5), PARD3(19), PTPN1(5), PTPN6(5), PTPRB(28), PTPRF(26), PTPRJ(18), PTPRM(15), PVRL1(10), PVRL2(5), PVRL3(7), PVRL4(4), RAC1(1), RAC2(2), RHOA(3), SMAD2(9), SMAD3(7), SMAD4(5), SNAI1(2), SNAI2(5), SORBS1(18), SRC(3), SSX2IP(11), TCF7(3), TCF7L1(4), TCF7L2(11), TGFBR1(6), TGFBR2(6), TJP1(24), VCL(11), WAS(11), WASF1(3), WASF2(3), WASF3(8), WASL(8), YES1(8) 43898605 823 160 746 210 244 294 162 11 106 6 0.000125 1.000 1.000 284 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(8), ATM(54), BUB1(10), BUB1B(6), BUB3(4), CCNA1(5), CCNA2(7), CCNB1(8), CCNB2(5), CCNB3(33), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNH(7), CDAN1(9), CDC14A(6), CDC14B(6), CDC20(4), CDC25A(8), CDC25B(3), CDC25C(5), CDC6(3), CDC7(11), CDH1(14), CDK2(2), CDK4(2), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(13), DTX4(4), E2F1(9), E2F2(3), E2F3(4), E2F4(3), E2F5(5), E2F6(1), EP300(32), ESPL1(12), GSK3B(13), HDAC1(5), HDAC2(3), HDAC3(12), HDAC4(14), HDAC5(12), HDAC6(24), HDAC8(1), MAD1L1(12), MAD2L1(3), MAD2L2(2), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(5), MPEG1(9), MPL(7), PCNA(3), PLK1(4), PRKDC(54), PTPRA(10), PTTG1(2), RB1(26), RBL1(13), SKP2(6), SMAD4(5), TBC1D8(15), TFDP1(13), TGFB1(1), TP53(74), WEE1(2) 40838039 734 157 692 196 220 236 135 5 128 10 0.0178 1.000 1.000 285 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRB2(7), ADRB3(3), ANXA6(12), ARRB1(4), ARRB2(5), ATP1A4(24), ATP1B1(6), ATP1B2(5), ATP1B3(3), ATP2A2(8), ATP2A3(11), ATP2B1(15), ATP2B2(12), ATP2B3(16), CACNA1A(19), CACNA1B(31), CACNA1C(38), CACNA1D(28), CACNA1E(58), CACNA1S(34), CACNB1(11), CACNB3(5), CALM1(2), CALM2(3), CALR(3), CAMK1(3), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CAMK4(5), CASQ1(7), CASQ2(9), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), GJA1(5), GJA4(1), GJA5(6), GJB1(3), GJB2(3), GJB3(4), GJB4(6), GJB5(2), GJB6(3), GNA11(2), GNAI2(6), GNAI3(4), GNAO1(6), GNAQ(3), GNAZ(4), GNB1(2), GNB2(5), GNB3(2), GNB4(4), GNB5(3), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GRK4(10), GRK5(8), GRK6(2), ITPR1(34), ITPR2(35), ITPR3(22), KCNB1(13), KCNJ3(9), KCNJ5(7), MIB1(9), MYCBP(2), NME7(4), PEA15(2), PKIA(1), PLCB3(11), PLN(2), PRKACA(6), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), PRKCZ(2), PRKD1(8), RGS1(6), RGS10(2), RGS11(1), RGS14(4), RGS16(5), RGS17(4), RGS18(3), RGS19(3), RGS2(3), RGS20(2), RGS3(8), RGS4(6), RGS5(4), RGS6(10), RGS7(9), RGS9(11), RYR1(73), RYR2(109), RYR3(93), SLC8A1(13), SLC8A3(13), USP5(13), YWHAH(3), YWHAQ(1) 69521324 1367 153 1337 521 472 502 216 11 155 11 0.456 1.000 1.000 286 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(12), BRAF(10), CACNA1A(19), CRH(1), CRHR1(3), GNA11(2), GNA12(7), GNA13(7), GNAI1(5), GNAI2(6), GNAI3(4), GNAO1(6), GNAQ(3), GNAS(24), GNAZ(4), GRIA1(12), GRIA2(21), GRIA3(21), GRID2(17), GRM1(26), GRM5(26), GUCY1A2(10), GUCY1A3(11), GUCY1B3(7), GUCY2C(14), GUCY2D(7), GUCY2F(27), HRAS(1), IGF1(5), IGF1R(13), ITPR1(34), ITPR2(35), ITPR3(22), KRAS(52), LYN(9), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NOS1(18), NOS3(11), NPR1(11), NPR2(11), NRAS(9), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PPP2CA(6), PPP2CB(4), PPP2R1A(31), PPP2R1B(5), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PRKCA(11), PRKCG(8), PRKG1(11), PRKG2(11), RAF1(9), RYR1(73) 40168024 836 149 760 261 252 348 127 9 98 2 0.0235 1.000 1.000 287 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(3), ACTG1(6), CHAD(3), COL11A1(35), COL11A2(10), COL17A1(20), COL1A1(12), COL1A2(24), COL2A1(16), COL3A1(18), COL4A1(21), COL4A2(14), COL4A4(23), COL4A6(31), COL5A1(30), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(12), COL6A3(44), COL6A6(27), COMP(7), DES(7), DSC1(18), DSC2(13), DSC3(20), DSG1(24), DSG2(15), DSG3(23), DSG4(15), FN1(42), GJA1(5), GJA10(10), GJA3(5), GJA4(1), GJA5(6), GJA8(6), GJA9(15), GJB1(3), GJB2(3), GJB3(4), GJB4(6), GJB5(2), GJB6(3), GJB7(8), GJC1(2), GJC3(2), GJD2(8), GJD4(3), IBSP(7), INA(4), ITGA6(12), ITGB4(8), KRT1(8), KRT10(3), KRT12(8), KRT13(6), KRT14(9), KRT15(10), KRT16(8), KRT17(4), KRT18(1), KRT19(6), KRT2(7), KRT20(4), KRT23(10), KRT24(5), KRT25(7), KRT27(4), KRT28(4), KRT3(9), KRT31(8), KRT32(10), KRT33A(7), KRT33B(5), KRT34(8), KRT35(9), KRT36(6), KRT37(8), KRT38(8), KRT39(14), KRT4(10), KRT40(5), KRT5(7), KRT6A(4), KRT6B(9), KRT6C(8), KRT7(3), KRT71(5), KRT72(6), KRT73(7), KRT74(1), KRT75(4), KRT76(6), KRT77(7), KRT78(5), KRT79(5), KRT8(7), KRT81(4), KRT82(1), KRT83(4), KRT84(7), KRT85(6), KRT86(1), KRT9(8), LAMA1(31), LAMA2(61), LAMA3(29), LAMA4(16), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(15), LAMB4(30), LAMC1(18), LAMC2(17), LAMC3(17), LMNA(7), LMNB1(5), LMNB2(4), NES(27), RELN(48), SPP1(2), THBS1(10), THBS2(20), THBS3(3), THBS4(12), TNC(26), TNN(19), TNR(14), TNXB(19), VIM(8), VTN(3), VWF(25) 88632952 1579 144 1545 531 473 613 248 19 210 16 0.113 1.000 1.000 288 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ATF4(3), CACNA1C(38), CACNA1D(28), CACNA1F(38), CACNA1S(34), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CDC42(3), CGA(1), EGFR(12), ELK1(3), GNA11(2), GNAQ(3), GNAS(24), GNRH1(1), GNRH2(1), GNRHR(4), GRB2(3), HBEGF(2), HRAS(1), ITPR1(34), ITPR2(35), ITPR3(22), JUN(1), KRAS(52), LHB(2), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K2(12), MAP3K3(8), MAP3K4(21), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK7(14), MAPK8(11), MAPK9(4), MMP14(7), MMP2(7), NRAS(9), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLD1(13), PLD2(10), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCD(5), PRKX(2), PTK2B(15), RAF1(9), SOS1(13), SOS2(17), SRC(3) 46763646 925 142 857 278 313 329 147 13 114 9 0.00245 1.000 1.000 289 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(56), AXIN1(9), CCND1(14), CCND2(9), CCND3(4), CSNK1E(3), CTNNB1(80), DVL1(3), DVL2(10), DVL3(9), FBXW2(4), FOSL1(3), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GSK3B(13), JUN(1), LDLR(7), MAPK10(10), MAPK9(4), MYC(8), PAFAH1B1(3), PPP2R5C(7), PPP2R5E(8), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(2), PRKD1(8), RAC1(1), RHOA(3), SFRP4(9), TCF7(3), WNT1(1), WNT10A(2), WNT10B(1), WNT11(5), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT4(1), WNT5A(6), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2) 20506676 450 140 381 138 132 172 86 4 53 3 0.0546 1.000 1.000 290 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(11), CD36(8), CD44(5), CD47(6), CHAD(3), COL11A1(35), COL11A2(10), COL1A1(12), COL1A2(24), COL2A1(16), COL3A1(18), COL4A1(21), COL4A2(14), COL4A4(23), COL4A6(31), COL5A1(30), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(12), COL6A3(44), COL6A6(27), DAG1(6), FN1(42), FNDC1(34), FNDC3A(7), FNDC4(3), FNDC5(2), GP5(3), GP6(2), GP9(1), HMMR(12), HSPG2(22), IBSP(7), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(11), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(19), ITGA9(16), ITGAV(10), ITGB1(8), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), LAMA1(31), LAMA2(61), LAMA3(29), LAMA4(16), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(15), LAMB4(30), LAMC1(18), LAMC2(17), LAMC3(17), RELN(48), SDC1(1), SDC2(1), SDC3(2), SDC4(4), SPP1(2), SV2A(14), SV2B(13), SV2C(17), THBS1(10), THBS2(20), THBS3(3), THBS4(12), TNC(26), TNN(19), TNR(14), TNXB(19), VTN(3), VWF(25) 79695637 1302 136 1274 450 376 505 201 15 188 17 0.306 1.000 1.000 291 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 56 ALG2(2), BAK1(3), BAX(2), BFAR(7), BTK(12), CAD(25), CASP10(8), CASP3(4), CASP8(21), CD7(3), CDK2AP1(1), CSNK1A1(3), DAXX(9), DEDD(2), DEDD2(2), DIABLO(3), EGFR(12), EPHB2(11), FADD(1), FAF1(10), FAIM2(3), MAP2K4(9), MAP2K7(4), MAP3K1(30), MAP3K5(25), MAPK1(2), MAPK10(10), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4), MET(17), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), NR0B2(2), PFN1(1), PFN2(2), PTPN13(29), RALBP1(6), RIPK1(8), ROCK1(22), SMPD1(4), TP53(74), TPX2(12), TRAF2(3), TUFM(2) 24662302 481 136 447 122 125 176 80 1 93 6 0.00921 1.000 1.000 292 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(5), ACTA2(7), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADM(2), ARRB1(4), ARRB2(5), ATF1(6), ATF2(8), ATF3(3), ATF4(3), ATF5(6), ATP2A2(8), ATP2A3(11), CACNB3(5), CALCA(1), CALM1(2), CALM2(3), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CNN1(3), CNN2(1), CORIN(12), CRH(1), CRHR1(3), DGKZ(10), ETS2(6), FOS(3), GABPA(7), GABPB2(12), GBA2(9), GJA1(5), GNAQ(3), GNB1(2), GNB2(5), GNB3(2), GNB4(4), GNB5(3), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GRK4(10), GRK5(8), GRK6(2), GSTO1(3), GUCA2B(1), GUCY1A3(11), IGFBP1(4), IGFBP2(4), IGFBP3(4), IGFBP4(3), IGFBP6(2), IL1B(2), IL6(5), ITPR1(34), ITPR2(35), ITPR3(22), JUN(1), MIB1(9), MYL2(2), MYLK2(8), NFKB1(10), NOS1(18), NOS3(11), OXTR(4), PDE4B(9), PDE4D(9), PKIA(1), PLCB3(11), PLCD1(4), PLCG1(12), PLCG2(27), PRKACA(6), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), PRKCD(5), PRKCE(10), PRKCH(10), PRKCQ(9), PRKCZ(2), PRKD1(8), RAMP1(1), RAMP3(2), RGS1(6), RGS10(2), RGS11(1), RGS14(4), RGS16(5), RGS17(4), RGS18(3), RGS19(3), RGS2(3), RGS20(2), RGS3(8), RGS4(6), RGS5(4), RGS6(10), RGS7(9), RGS9(11), RLN1(1), RYR1(73), RYR2(109), RYR3(93), SLC8A1(13), SP1(7), TNXB(19), USP5(13), YWHAH(3), YWHAQ(1) 62417276 1139 135 1111 424 375 422 192 7 133 10 0.520 1.000 1.000 293 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), AKAP1(9), AKAP10(9), AKAP11(23), AKAP12(21), AKAP2(11), AKAP3(21), AKAP4(15), AKAP5(3), AKAP6(34), AKAP7(7), AKAP8(7), AKAP9(52), ARHGEF1(12), CALM1(2), CALM2(3), CHMP1B(1), GNA11(2), GNA12(7), GNA13(7), GNA14(7), GNA15(1), GNAI2(6), GNAI3(4), GNAL(6), GNAO1(6), GNAQ(3), GNAZ(4), GNB1(2), GNB2(5), GNB3(2), GNB5(3), GNG12(1), GNG13(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GNGT2(3), HRAS(1), IL18BP(1), ITPR1(34), KCNJ3(9), KRAS(52), NRAS(9), PALM2(10), PDE1A(14), PDE1B(7), PDE1C(11), PDE4A(8), PDE4B(9), PDE4C(2), PDE4D(9), PDE7A(1), PDE7B(7), PDE8A(7), PDE8B(19), PLCB3(11), PPP3CA(4), PPP3CC(6), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(2), PRKD1(8), PRKD3(11), RHOA(3), RRAS(3), SLC9A1(7), USP5(13) 42506319 831 134 771 294 255 289 169 7 105 6 0.442 1.000 1.000 294 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 246 ACVR1(8), ACVR1B(8), ACVR2A(7), ACVR2B(5), AMHR2(3), BMP2(6), BMP7(12), BMPR1A(5), BMPR1B(6), BMPR2(12), CCL1(1), CCL13(2), CCL14(1), CCL15(1), CCL16(1), CCL17(1), CCL18(1), CCL21(1), CCL23(3), CCL24(3), CCL25(1), CCL28(2), CCL4(5), CCL5(2), CCL7(4), CCL8(2), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CCR9(4), CD27(4), CD40(1), CD40LG(6), CD70(2), CLCF1(1), CNTF(3), CNTFR(4), CRLF2(5), CSF1(6), CSF1R(8), CSF2(1), CSF2RA(10), CSF2RB(14), CSF3(1), CSF3R(7), CX3CL1(3), CX3CR1(6), CXCL1(3), CXCL10(2), CXCL12(3), CXCL13(2), CXCL2(2), CXCL3(1), CXCL5(3), CXCL9(2), CXCR3(5), CXCR4(1), CXCR6(1), EDA(4), EDA2R(6), EDAR(5), EGF(19), EGFR(12), EPO(3), EPOR(4), FAS(8), FASLG(7), FLT1(20), FLT3(16), FLT3LG(2), FLT4(8), GDF5(7), GH1(2), GH2(1), GHR(8), HGF(14), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(10), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(3), IL10(4), IL10RA(4), IL10RB(6), IL11(2), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL13RA1(11), IL15(2), IL17RA(5), IL17RB(5), IL18(2), IL18R1(9), IL18RAP(14), IL19(2), IL1B(2), IL1R1(5), IL1R2(5), IL1RAP(8), IL2(2), IL20(9), IL20RA(4), IL21(3), IL21R(7), IL22RA1(4), IL22RA2(1), IL23A(4), IL23R(5), IL24(5), IL25(2), IL26(3), IL2RA(4), IL2RB(3), IL2RG(11), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL6ST(11), IL7(1), IL7R(12), IL9(1), IL9R(3), INHBA(7), INHBB(2), INHBC(3), INHBE(6), KDR(26), KIT(23), KITLG(3), LEP(2), LEPR(12), LIF(3), LIFR(27), LTA(3), LTBR(5), MET(17), MPL(7), NGFR(3), OSM(2), OSMR(13), PDGFB(2), PDGFC(3), PDGFRA(24), PDGFRB(12), PF4(1), PF4V1(1), PLEKHO2(6), PPBP(1), PRL(9), PRLR(5), RELT(2), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFRSF11A(4), TNFRSF11B(13), TNFRSF13B(3), TNFRSF14(2), TNFRSF17(1), TNFRSF19(4), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(2), TNFRSF8(6), TNFRSF9(2), TNFSF10(1), TNFSF11(7), TNFSF12(6), TNFSF13(3), TNFSF13B(5), TNFSF14(2), TNFSF15(3), TNFSF18(4), TNFSF4(4), TNFSF8(1), TNFSF9(6), TPO(14), TSLP(2), VEGFA(2), VEGFB(3), VEGFC(6), XCL2(2), XCR1(3) 63931396 1130 132 1109 352 280 442 224 7 172 5 0.0340 1.000 1.000 295 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 127 ALCAM(7), CADM1(4), CADM3(10), CD2(4), CD22(14), CD226(6), CD274(1), CD276(2), CD28(3), CD34(1), CD4(6), CD40(1), CD40LG(6), CD58(2), CD6(6), CD80(5), CD86(5), CD8A(2), CD8B(1), CDH1(14), CDH15(8), CDH2(18), CDH3(5), CDH4(17), CDH5(6), CLDN1(3), CLDN10(7), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CNTN1(18), CNTN2(6), CNTNAP1(12), CNTNAP2(31), CTLA4(2), ESAM(1), F11R(1), GLG1(8), HLA-A(1), HLA-B(2), HLA-C(2), HLA-DMA(3), HLA-DOA(2), HLA-DOB(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), ICAM1(2), ICAM2(3), ICAM3(3), ICOS(3), ICOSLG(2), ITGA4(10), ITGA6(12), ITGA8(19), ITGA9(16), ITGAL(17), ITGAM(21), ITGAV(10), ITGB1(8), ITGB2(15), ITGB7(4), ITGB8(9), JAM2(9), JAM3(2), L1CAM(20), MADCAM1(2), MAG(7), MPZ(3), MPZL1(3), NCAM1(10), NCAM2(33), NEGR1(7), NEO1(17), NFASC(31), NLGN1(9), NLGN2(8), NLGN3(25), NRCAM(15), NRXN1(34), NRXN2(16), NRXN3(27), OCLN(2), PDCD1(3), PDCD1LG2(1), PTPRC(17), PTPRF(26), PTPRM(15), PVR(3), PVRL1(10), PVRL2(5), PVRL3(7), SDC1(1), SDC2(1), SDC3(2), SDC4(4), SELE(5), SELL(5), SELP(13), SELPLG(9), SIGLEC1(11), SPN(1), VCAM1(12), VCAN(64) 51647538 954 132 926 315 292 368 160 4 121 9 0.0264 1.000 1.000 296 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), CSNK1D(3), DRD1(6), DRD2(8), EGF(19), EGFR(12), GJA1(5), GJD2(8), GNA11(2), GNAI1(5), GNAI2(6), GNAI3(4), GNAQ(3), GNAS(24), GRB2(3), GRM1(26), GRM5(26), GUCY1A2(10), GUCY1A3(11), GUCY1B3(7), GUCY2C(14), GUCY2D(7), GUCY2F(27), HRAS(1), HTR2A(11), HTR2B(2), HTR2C(16), ITPR1(34), ITPR2(35), ITPR3(22), KRAS(52), MAP2K1(2), MAP2K2(5), MAP2K5(3), MAP3K2(12), MAPK1(2), MAPK3(3), MAPK7(14), NPR1(11), NPR2(11), NRAS(9), PDGFA(3), PDGFB(2), PDGFC(3), PDGFD(8), PDGFRA(24), PDGFRB(12), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKG1(11), PRKG2(11), PRKX(2), RAF1(9), SOS1(13), SOS2(17), SRC(3), TJP1(24), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(10), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4) 47468487 938 132 871 287 280 357 178 12 107 4 0.00734 1.000 1.000 297 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(21), ADCY8(22), ARAF(12), ATF4(3), BRAF(10), CACNA1C(38), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CAMK4(5), CREBBP(32), EP300(32), GNAQ(3), GRIA1(12), GRIA2(21), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), GRM1(26), GRM5(26), HRAS(1), ITPR1(34), ITPR2(35), ITPR3(22), KRAS(52), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NRAS(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PPP1CA(2), PPP1CB(9), PPP1CC(2), PPP1R12A(8), PPP1R1A(2), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKX(2), RAF1(9), RAP1A(4), RAP1B(2), RAPGEF3(8), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA6(19) 36763828 725 131 661 232 213 271 142 6 90 3 0.0678 1.000 1.000 298 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(17), BAD(1), BAK1(3), BAX(2), BCL2L1(4), BCL2L11(6), BID(2), BIRC2(10), BIRC3(5), BIRC5(5), BNIP3L(1), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CHUK(8), CYCS(2), DFFB(4), FADD(1), FAS(8), FASLG(7), GZMB(4), HELLS(12), IKBKB(13), IKBKG(3), IRF1(1), IRF2(5), IRF3(2), IRF4(8), IRF5(6), IRF6(9), IRF7(1), JUN(1), LTA(3), MAP2K4(9), MAP3K1(30), MAPK10(10), MDM2(5), MYC(8), NFKB1(10), NFKBIA(3), NFKBIB(1), NFKBIE(6), PLEKHG5(5), PRF1(8), RELA(6), RIPK1(8), TNFRSF10B(5), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(2), TNFSF10(1), TP53(74), TP73(5), TRAF1(5), TRAF2(3), TRAF3(5) 20246836 437 127 405 108 109 162 74 3 88 1 0.00729 1.000 1.000 299 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(4), AKT2(6), AKT3(11), ANKRD6(8), APC(56), AXIN1(9), AXIN2(9), CER1(4), CSNK1A1(3), CTNNB1(80), DACT1(14), DKK1(3), DKK2(3), DKK3(1), DKK4(3), DVL1(3), FSTL1(4), GSK3A(10), GSK3B(13), LRP1(51), MVP(14), NKD1(3), PSEN1(5), PTPRA(10), SENP2(11), SFRP1(6), TSHB(3), WIF1(5) 14398562 352 126 286 95 110 149 53 2 35 3 0.0114 1.000 1.000 300 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(2), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADK(2), ADSL(8), ADSS(6), ADSSL1(5), AK1(1), AK2(3), AK5(8), AK7(13), ALLC(8), AMPD1(23), AMPD2(6), AMPD3(7), ATIC(7), CANT1(1), DCK(3), ENPP1(12), ENPP3(17), ENTPD1(4), ENTPD3(5), ENTPD4(2), ENTPD5(2), ENTPD6(11), ENTPD8(5), FHIT(4), GART(9), GDA(4), GMPR(6), GMPR2(3), GMPS(14), GUCY1A2(10), GUCY1A3(11), GUCY1B3(7), GUCY2C(14), GUCY2D(7), GUCY2F(27), GUK1(5), HPRT1(2), IMPDH1(6), ITPA(1), NME1(2), NME2(3), NME4(1), NME6(2), NME7(4), NPR1(11), NPR2(11), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5E(6), NT5M(2), NUDT2(2), NUDT5(2), NUDT9(1), PAICS(4), PAPSS1(8), PAPSS2(7), PDE10A(14), PDE11A(12), PDE1A(14), PDE1C(11), PDE2A(14), PDE3B(15), PDE4A(8), PDE4B(9), PDE4C(2), PDE4D(9), PDE5A(14), PDE6D(2), PDE6G(1), PDE6H(1), PDE7A(1), PDE7B(7), PDE8A(7), PDE8B(19), PDE9A(8), PFAS(11), PKLR(6), PNPT1(7), POLA1(29), POLA2(3), POLD1(10), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLR1A(15), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(2), POLR3H(4), PPAT(9), PRIM1(3), PRPS1(2), PRPS1L1(5), PRPS2(4), PRUNE(5), RFC5(8), RRM1(2), RRM2(6), RRM2B(5), XDH(14) 59133569 1014 125 983 308 313 343 188 10 156 4 0.0338 1.000 1.000 301 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 149 ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(4), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRA2A(6), ADRA2C(2), ADRB2(7), ADRB3(3), AGTR1(4), AGTR2(11), AVPR1A(7), AVPR1B(3), AVPR2(4), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), CCKAR(9), CCKBR(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CCR9(4), CCRL2(1), CHML(10), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CMKLR1(9), CNR1(11), CNR2(6), CX3CR1(6), CXCR3(5), CXCR4(1), DRD1(6), DRD2(8), DRD3(6), DRD5(11), EDNRA(5), EDNRB(4), F2R(6), F2RL1(4), F2RL2(2), FPR1(2), FSHR(15), GALR1(3), GALR3(2), GALT(3), GHSR(8), GNB2L1(1), GPR17(6), GPR173(6), GPR174(12), GPR3(5), GPR35(3), GPR37(9), GPR37L1(5), GPR4(9), GPR50(8), GPR6(4), GPR63(5), GPR83(3), GPR85(7), GPR87(7), GRPR(4), HCRTR2(11), HRH1(10), HRH2(4), HRH3(2), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(16), HTR4(6), HTR5A(12), HTR6(4), HTR7(5), LHCGR(17), LTB4R(2), MAS1(3), MC1R(3), MC3R(5), MC4R(5), MC5R(14), MLNR(3), MTNR1A(5), MTNR1B(4), NMBR(4), NMUR1(4), NMUR2(8), NPY1R(9), NPY2R(5), NPY5R(13), NTSR1(5), NTSR2(1), OPN1SW(6), OPN3(2), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(11), OXTR(4), P2RY1(3), P2RY10(8), P2RY11(7), P2RY12(5), P2RY13(2), P2RY14(6), P2RY2(3), P2RY6(4), PTAFR(4), PTGDR(9), PTGER2(3), PTGER4(12), PTGFR(10), PTGIR(3), RGR(6), RHO(4), RRH(2), SSTR1(9), SSTR2(3), SSTR3(3), SSTR4(10), SUCNR1(3), TRHR(3) 39736749 844 124 820 320 285 339 141 11 66 2 0.0615 1.000 1.000 302 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(8), ACVR1B(8), ACVR1C(6), ACVR2A(7), ACVR2B(5), ACVRL1(2), AMHR2(3), BMP2(6), BMP4(10), BMP5(14), BMP6(5), BMP7(12), BMP8A(3), BMP8B(1), BMPR1A(5), BMPR1B(6), BMPR2(12), CHRD(12), COMP(7), CREBBP(32), CUL1(13), DCN(11), E2F4(3), E2F5(5), EP300(32), FST(4), GDF5(7), GDF6(3), ID1(2), ID2(1), IFNG(10), INHBA(7), INHBB(2), INHBC(3), INHBE(6), LEFTY1(4), LEFTY2(1), LTBP1(17), MAPK1(2), MAPK3(3), MYC(8), NODAL(3), NOG(2), PITX2(8), PPP2CA(6), PPP2CB(4), PPP2R1A(31), PPP2R1B(5), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), RBL1(13), RBL2(19), RBX1(1), RHOA(3), ROCK1(22), ROCK2(17), RPS6KB1(3), RPS6KB2(4), SMAD1(2), SMAD2(9), SMAD3(7), SMAD4(5), SMAD5(9), SMAD7(3), SMAD9(2), SMURF1(12), SMURF2(8), SP1(7), TFDP1(13), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6), THBS1(10), THBS2(20), THBS3(3), THBS4(12), ZFYVE16(18), ZFYVE9(18) 35156888 658 120 627 184 223 211 117 4 97 6 0.0186 1.000 1.000 303 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(5), ACTA2(7), ACTN2(16), ACTN4(8), DES(7), DMD(84), MYBPC1(16), MYBPC2(13), MYBPC3(13), MYH3(31), MYH6(16), MYH7(35), MYH8(29), MYL1(5), MYL2(2), MYL3(1), MYL9(3), MYOM1(35), NEB(114), TMOD1(4), TNNC2(3), TNNI1(1), TNNI2(4), TNNI3(4), TNNT1(4), TNNT2(8), TNNT3(4), TPM1(3), TPM2(1), TPM3(5), TPM4(4), TTN(491), VIM(8) 52150257 984 119 947 313 275 407 205 3 66 28 0.529 1.000 1.000 304 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(4), AKT3(11), BCAR1(8), CAPN1(5), CAPN10(6), CAPN11(9), CAPN2(11), CAPN3(11), CAPN5(9), CAPN6(13), CAPN7(9), CAPN9(11), CAPNS1(2), CAV1(2), CAV2(1), CDC42(3), CRK(2), CSK(1), DOCK1(21), FYN(5), GIT2(9), GRB2(3), ILK(5), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(11), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(19), ITGA9(16), ITGAD(11), ITGAE(9), ITGAL(17), ITGAM(21), ITGAV(10), ITGAX(14), ITGB1(8), ITGB2(15), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAPK10(10), MAPK12(2), MAPK4(4), MAPK6(11), MAPK7(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PDPK1(3), PIK3R2(7), PTK2(12), PXN(6), RAC1(1), RAC2(2), RAP1B(2), RAPGEF1(10), RHO(4), ROCK1(22), ROCK2(17), SDCCAG8(13), SEPP1(1), SHC1(6), SHC3(15), SORBS1(18), SOS1(13), SRC(3), TLN1(23), TNS1(19), VASP(3), VAV2(7), VAV3(13), VCL(11), ZYX(11) 48776737 785 114 763 284 235 289 132 5 117 7 0.594 1.000 1.000 305 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADK(2), ADSL(8), ADSS(6), AK1(1), AK2(3), AK5(8), ALLC(8), AMPD1(23), AMPD2(6), AMPD3(7), ATIC(7), ATP1B1(6), ATP5A1(8), ATP5B(5), ATP5C1(1), ATP5D(1), ATP5F1(4), ATP5G1(2), ATP5G2(1), ATP5G3(1), ATP5H(1), ATP5I(2), ATP5J(3), CANT1(1), DCK(3), ENPP1(12), ENPP3(17), ENTPD1(4), FHIT(4), GART(9), GDA(4), GMPS(14), GUCY1A2(10), GUCY1A3(11), GUCY1B3(7), GUCY2C(14), GUCY2D(7), GUCY2F(27), GUK1(5), HPRT1(2), IMPDH1(6), ITPA(1), NME1(2), NME2(3), NPR1(11), NPR2(11), NT5C(1), NT5E(6), NT5M(2), NUDT2(2), PAICS(4), PAPSS1(8), PAPSS2(7), PDE1A(14), PDE4A(8), PDE4B(9), PDE4C(2), PDE4D(9), PDE5A(14), PDE6B(5), PDE6C(12), PDE6G(1), PDE7B(7), PDE8A(7), PDE9A(8), PFAS(11), PKLR(6), POLB(4), POLD1(10), POLD2(6), POLE(47), POLG(6), POLL(6), POLQ(29), POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLRMT(11), PPAT(9), PRPS1(2), PRPS1L1(5), PRPS2(4), PRUNE(5), RRM1(2), RRM2(6) 46086103 794 112 771 247 247 287 145 4 107 4 0.114 1.000 1.000 306 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(2), CDC40(9), CLK2(8), CLK3(6), CLK4(7), COL2A1(16), CPSF1(11), CPSF2(15), CPSF3(8), CPSF4(1), CSTF1(4), CSTF2(13), CSTF2T(5), CSTF3(9), DDIT3(2), DDX1(5), DDX20(4), DHX15(9), DHX16(11), DHX38(10), DHX8(9), DHX9(14), DICER1(36), DNAJC8(1), FUS(2), GIPC1(2), METTL3(6), NCBP1(9), NCBP2(3), NONO(17), NXF1(4), PABPN1(3), PAPOLA(13), PHF5A(1), POLR2A(21), PPM1G(8), PRPF18(5), PRPF3(10), PRPF4(5), PRPF4B(17), PRPF8(26), PSKH1(8), PTBP1(4), PTBP2(10), RBM17(4), RBM5(6), RNGTT(11), RNMT(7), RNPS1(3), SF3A1(4), SF3A2(2), SF3A3(8), SF3B1(16), SF3B2(9), SF3B4(4), SF3B5(2), SNRPA(2), SNRPB(1), SNRPB2(1), SNRPD1(1), SNRPD2(1), SNRPD3(3), SNRPE(1), SNRPN(4), SNURF(1), SPOP(23), SRPK1(10), SRPK2(6), SRRM1(12), SUPT5H(19), U2AF1(4), U2AF2(7), XRN2(19) 38070878 580 110 557 169 193 186 112 2 85 2 0.453 1.000 1.000 307 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(29), ABCA10(26), ABCA12(53), ABCA13(79), ABCA2(10), ABCA3(12), ABCA4(27), ABCA5(30), ABCA6(22), ABCA7(17), ABCA8(28), ABCA9(28), ABCB1(32), ABCB10(10), ABCB11(15), ABCB4(28), ABCB5(31), ABCB6(11), ABCB7(17), ABCB8(7), ABCB9(7), ABCC1(14), ABCC10(10), ABCC11(27), ABCC12(19), ABCC2(30), ABCC3(10), ABCC4(16), ABCC5(14), ABCC6(12), ABCC8(21), ABCC9(29), ABCD1(12), ABCD2(7), ABCD3(7), ABCD4(2), ABCG1(12), ABCG2(16), ABCG4(7), ABCG5(5), ABCG8(7), CFTR(14), TAP1(8), TAP2(1) 42524165 819 108 792 228 223 331 143 3 106 13 0.000224 1.000 1.000 308 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 56 ASH1L(42), ASH2L(12), CARM1(5), CTCFL(13), DOT1L(8), EED(12), EHMT1(23), EHMT2(2), EZH1(10), EZH2(15), FBXO11(8), HCFC1(26), HSF4(3), JMJD4(4), JMJD6(5), KDM6A(14), MEN1(8), NSD1(36), OGT(17), PAXIP1(10), PPP1CA(2), PPP1CB(9), PPP1CC(2), PRDM2(19), PRDM6(6), PRDM7(2), PRDM9(31), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), RBBP5(7), SATB1(18), SETD1A(12), SETD1B(18), SETD2(37), SETD7(7), SETD8(3), SETDB1(15), SETDB2(14), SETMAR(6), SMYD3(6), STK38(9), SUV39H1(7), SUV39H2(5), SUV420H1(15), SUZ12(13), WHSC1(19), WHSC1L1(17) 44102583 599 104 579 183 192 198 110 6 91 2 0.296 1.000 1.000 309 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 ACTB(3), BAD(1), CABIN1(19), CALM1(2), CALM2(3), CAMK2B(4), CAMK4(5), CD3E(2), CD3G(3), CD69(2), CDKN1A(1), CNR1(11), CREBBP(32), CSF2(1), CSNK2A1(9), CTLA4(2), EGR2(6), EGR3(7), EP300(32), FCER1A(9), FCGR3A(1), FKBP1B(1), FOS(3), FOSL1(3), GATA3(3), GATA4(3), GSK3A(10), GSK3B(13), HRAS(1), ICOS(3), IFNA1(2), IFNB1(3), IFNG(10), IL10(4), IL1B(2), IL2(2), IL2RA(4), IL3(2), IL4(1), IL6(5), ITK(7), KPNA5(7), MAP2K7(4), MAPK14(4), MAPK8(11), MAPK9(4), MEF2A(3), MEF2B(1), MEF2D(7), MYF5(6), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NFKB2(9), NFKBIB(1), NFKBIE(6), NPPB(2), NUP214(18), OPRD1(1), P2RX7(1), PAK1(3), PPIA(1), PPP3CB(6), PPP3CC(6), PPP3R1(1), PTPRC(17), RELA(6), RPL13A(1), SLA(4), SP1(7), SP3(10), TGFB1(1), TRAF2(3), TRPV6(10), VAV1(12), VAV2(7), VAV3(13), XPO5(11) 32447336 504 98 489 162 161 160 96 4 82 1 0.184 1.000 1.000 310 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(8), BRAF(10), CHUK(8), CREB1(5), DAXX(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IKBKB(13), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K5(3), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K11(5), MAP3K12(6), MAP3K13(13), MAP3K2(12), MAP3K3(8), MAP3K4(21), MAP3K5(25), MAP3K6(7), MAP3K7(9), MAP3K8(10), MAP3K9(6), MAP4K1(12), MAP4K2(5), MAP4K3(16), MAP4K4(10), MAP4K5(7), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK4(4), MAPK6(11), MAPK7(14), MAPK8(11), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(5), MAX(9), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), MKNK1(3), MKNK2(2), MYC(8), NFKB1(10), NFKBIA(3), PAK1(3), PAK2(3), RAC1(1), RAF1(9), RELA(6), RIPK1(8), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA4(2), RPS6KA5(11), RPS6KB1(3), RPS6KB2(4), SHC1(6), SP1(7), STAT1(15), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TRAF2(3) 34631614 591 98 575 161 183 211 99 3 92 3 0.0196 1.000 1.000 311 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(17), AMY2A(4), AMY2B(12), ASCC3(31), ATP13A2(5), DDX18(12), DDX19A(4), DDX23(9), DDX4(15), DDX41(3), DDX47(5), DDX50(10), DDX51(8), DDX52(4), DDX54(8), DDX55(6), DDX56(5), DHX58(6), ENPP1(12), ENPP3(17), ENTPD7(8), EP400(42), ERCC2(1), ERCC3(11), G6PC(5), G6PC2(11), GAA(4), GANC(15), GBA(4), GBE1(9), GCK(2), GPI(7), GUSB(5), GYS1(13), GYS2(16), HK1(11), HK2(9), HK3(9), IFIH1(5), LYZL1(4), MGAM(38), MOV10L1(19), NUDT5(2), NUDT8(1), PGM1(6), PGM3(3), PYGB(11), PYGL(8), PYGM(10), RAD54B(14), RAD54L(6), RUVBL2(4), SETX(33), SI(65), SKIV2L2(17), SMARCA2(24), SMARCA5(19), UGDH(2), UGP2(6), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2A1(9), UGT2A3(5), UGT2B10(18), UGT2B11(8), UGT2B15(9), UGT2B17(7), UGT2B28(15), UGT2B4(11), UGT2B7(5), UXS1(5) 45031394 809 97 782 198 214 282 191 9 107 6 0.000325 1.000 1.000 312 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(18), BDKRB1(3), BDKRB2(8), C1QA(4), C1QB(3), C1QC(4), C1R(11), C1S(8), C2(2), C3(22), C3AR1(9), C4BPA(6), C4BPB(6), C5(18), C5AR1(4), C6(16), C7(20), C8A(9), C8B(5), C8G(2), C9(19), CD46(3), CD55(6), CD59(4), CFB(3), CFH(22), CFI(8), CPB2(7), CR1(22), CR2(22), F10(12), F11(15), F12(2), F13A1(8), F13B(15), F2(8), F2R(6), F3(5), F5(47), F7(2), F8(45), F9(14), FGA(26), FGB(7), FGG(9), KLKB1(10), KNG1(11), MASP1(13), MASP2(7), MBL2(4), PLAT(6), PLAUR(7), PLG(14), PROC(4), PROS1(21), SERPINA1(4), SERPINA5(5), SERPINC1(10), SERPIND1(7), SERPINE1(5), SERPINF2(4), SERPING1(7), TFPI(8), THBD(1), VWF(25) 32691403 688 97 660 202 172 295 118 4 93 6 0.0489 1.000 1.000 313 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 106 A4GNT(7), ALG1(2), ALG10(6), ALG10B(6), ALG11(6), ALG12(6), ALG13(24), ALG14(2), ALG2(2), ALG6(5), ALG8(11), ALG9(2), B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), B4GALT5(2), B4GALT7(4), C1GALT1(2), C1GALT1C1(6), CHPF(5), CHST1(8), CHST11(8), CHST12(3), CHST14(3), CHST2(2), CHST3(4), CHST4(4), CHST6(6), CHST7(4), CHSY1(8), DAD1(2), DDOST(3), DPAGT1(3), EXT1(12), EXT2(6), EXTL1(9), EXTL2(8), EXTL3(10), FUT11(3), FUT8(10), GALNT1(10), GALNT10(8), GALNT11(12), GALNT12(6), GALNT13(18), GALNT14(6), GALNT2(10), GALNT3(8), GALNT4(8), GALNT5(5), GALNT6(1), GALNT7(12), GALNT8(11), GALNT9(8), GALNTL5(11), GANAB(10), GCNT1(5), GCNT3(5), GCNT4(1), HS2ST1(7), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), HS3ST5(9), HS6ST1(2), HS6ST2(9), HS6ST3(3), MAN1A1(13), MAN1A2(7), MAN1B1(5), MAN1C1(6), MAN2A1(20), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), MGAT5B(10), NDST1(14), NDST2(9), NDST3(14), NDST4(15), OGT(17), RPN1(3), RPN2(5), ST3GAL1(2), ST3GAL2(6), ST3GAL3(6), ST3GAL4(3), ST6GAL1(7), ST6GALNAC1(4), STT3B(5), UST(3), WBSCR17(15), XYLT1(16), XYLT2(4) 38860123 690 96 671 223 225 238 141 3 80 3 0.193 1.000 1.000 314 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(5), AK3(2), CAD(25), CANT1(1), CDA(2), CTPS2(7), DCK(3), DCTD(5), DHODH(3), DPYD(20), DPYS(6), DTYMK(2), ENTPD1(4), ENTPD3(5), ENTPD4(2), ENTPD5(2), ENTPD6(11), ENTPD8(5), ITPA(1), NME1(2), NME2(3), NME4(1), NME6(2), NME7(4), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5E(6), NT5M(2), NUDT2(2), PNPT1(7), POLA1(29), POLA2(3), POLD1(10), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLR1A(15), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(2), POLR3H(4), PRIM1(3), RFC5(8), RRM1(2), RRM2(6), RRM2B(5), TK1(3), TK2(6), TXNRD1(10), TXNRD2(5), UCK1(5), UCK2(5), UMPS(6), UPB1(10), UPP1(4), UPP2(4), UPRT(8) 29373971 481 94 462 156 144 168 91 5 72 1 0.303 1.000 1.000 315 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(6), APAF1(17), ARHGDIB(3), BAG4(5), BID(2), BIRC2(10), BIRC3(5), CASP2(6), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CFLAR(2), CHUK(8), CRADD(3), CYCS(2), DAXX(9), DFFB(4), FADD(1), GSN(4), LMNA(7), LMNB1(5), LMNB2(4), MAP2K7(4), MAP3K1(30), MAP3K5(25), MAPK8(11), MDM2(5), NFKB1(10), NFKBIA(3), NUMA1(20), PAK2(3), PRKCD(5), PRKDC(54), PSEN1(5), PSEN2(8), PTK2(12), RASA1(29), RB1(26), RELA(6), RIPK1(8), SPTAN1(31), TNFRSF1A(4), TNFRSF1B(2), TRAF1(5), TRAF2(3) 25165677 448 93 435 126 119 155 78 5 86 5 0.165 1.000 1.000 316 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(15), CD14(2), CD19(4), CD1A(5), CD1B(1), CD1C(15), CD1D(5), CD1E(6), CD2(4), CD22(14), CD33(6), CD34(1), CD36(8), CD37(2), CD38(6), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD44(5), CD5(10), CD55(6), CD59(4), CD7(3), CD8A(2), CD8B(1), CD9(2), CR1(22), CR2(22), CSF1(6), CSF1R(8), CSF2(1), CSF2RA(10), CSF3(1), CSF3R(7), DNTT(3), EPO(3), EPOR(4), FCER2(1), FCGR1A(6), FLT3(16), FLT3LG(2), GP5(3), GP9(1), HLA-DRA(1), HLA-DRB5(1), IL11(2), IL11RA(5), IL1B(2), IL1R1(5), IL1R2(5), IL2RA(4), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL7(1), IL7R(12), IL9R(3), ITGA1(17), ITGA2(19), ITGA2B(11), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGAM(21), ITGB3(11), KIT(23), KITLG(3), MME(11), MS4A1(7), TFRC(4), THPO(5), TPO(14) 29769275 524 91 514 182 123 207 99 3 89 3 0.473 1.000 1.000 317 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(29), ACSL1(13), ACSL3(7), ACSL4(21), ACSL5(8), ACSL6(12), ADIPOQ(2), ADIPOR1(3), ADIPOR2(7), AGRP(2), AKT1(4), AKT2(6), AKT3(11), CAMKK1(11), CAMKK2(6), CD36(8), CHUK(8), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), G6PC(5), G6PC2(11), IKBKB(13), IKBKG(3), IRS1(13), IRS4(20), JAK1(20), JAK2(17), JAK3(10), LEP(2), LEPR(12), MAPK10(10), MAPK8(11), MAPK9(4), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NPY(2), PCK1(9), PCK2(7), POMC(4), PPARA(2), PPARGC1A(9), PRKAA1(8), PRKAA2(11), PRKAB1(6), PRKAB2(1), PRKAG1(3), PRKAG2(4), PRKAG3(6), PRKCQ(9), PTPN11(8), RELA(6), RXRA(3), RXRG(9), SLC2A1(2), SLC2A4(9), STAT3(11), STK11(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3), TYK2(10) 28958077 522 90 511 183 147 191 94 5 81 4 0.454 1.000 1.000 318 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(12), CD28(3), CD3D(6), CSK(1), CTLA4(2), DAG1(6), DTYMK(2), EPHB2(11), FBXW7(44), GRB2(3), ITK(7), ITPKA(1), ITPKB(11), LCK(4), LCP2(5), MAPK1(2), NCK1(4), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PLCG1(12), PTPRC(17), RAF1(9), RASGRP1(8), RASGRP2(4), RASGRP3(11), RASGRP4(6), SOS1(13), SOS2(17), VAV1(12), ZAP70(8) 19923014 322 88 299 110 97 113 55 4 51 2 0.622 1.000 1.000 319 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(11), CREBBP(32), CTBP1(1), CTBP2(3), DLL1(6), DLL3(6), DLL4(6), DTX1(7), DTX2(4), DTX3(5), DTX3L(7), DTX4(4), DVL1(3), DVL2(10), DVL3(9), EP300(32), HDAC1(5), HDAC2(3), HES1(1), JAG1(22), JAG2(2), LFNG(2), MAML1(6), MAML2(9), MAML3(13), MFNG(2), NCOR2(24), NCSTN(9), NOTCH1(10), NOTCH2(18), NOTCH3(29), NOTCH4(9), NUMB(9), NUMBL(4), PSEN1(5), PSEN2(8), RBPJ(5), RBPJL(8), SNW1(6) 22970247 355 85 346 122 129 105 57 6 56 2 0.302 1.000 1.000 320 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(4), AKT2(6), AKT3(11), ASAH1(6), BRAF(10), DAG1(6), DRD2(8), EGFR(12), EPHB2(11), GRB2(3), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), PI3(2), PIK3CB(17), PITX2(8), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), RAF1(9), RGS20(2), SHC1(6), SOS1(13), SOS2(17), SRC(3), STAT3(11), TERF2IP(2) 21223221 335 84 324 136 100 126 56 5 46 2 0.919 1.000 1.000 321 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(4), APC(56), ASAH1(6), CAMP(1), DAG1(6), DLG4(10), EPHB2(11), GNAI1(5), GNAQ(3), ITPR1(34), ITPR2(35), ITPR3(22), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), PITX2(8), PTX3(2), RAC1(1), RHO(4), RYR1(73) 16749934 303 84 292 127 82 140 34 3 40 4 0.875 1.000 1.000 322 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(6), BMP4(10), BMP5(14), BMP6(5), BMP7(12), BMP8A(3), BMP8B(1), BTRC(14), CSNK1A1(3), CSNK1A1L(4), CSNK1D(3), CSNK1E(3), CSNK1G1(6), CSNK1G2(2), CSNK1G3(8), DHH(2), FBXW11(5), GLI1(13), GLI2(10), GLI3(28), GSK3B(13), HHIP(12), IHH(3), LRP2(91), PRKACA(6), PRKACB(3), PRKACG(9), PRKX(2), PTCH1(22), PTCH2(11), RAB23(4), SHH(4), SMO(9), STK36(5), SUFU(3), WNT1(1), WNT10A(2), WNT10B(1), WNT11(5), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT3A(1), WNT4(1), WNT5A(6), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2), ZIC2(1) 20670823 408 81 399 141 149 156 55 4 42 2 0.280 1.000 1.000 323 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(4), ADAM17(11), ATP6AP1(7), ATP6V0A1(8), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), CASP3(4), CCL5(2), CDC42(3), CHUK(8), CSK(1), CXCL1(3), EGFR(12), F11R(1), GIT1(9), HBEGF(2), IGSF5(5), IKBKB(13), IKBKG(3), JAM2(9), JAM3(2), JUN(1), LYN(9), MAP2K4(9), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK8(11), MAPK9(4), MET(17), NFKB1(10), NFKB2(9), NFKBIA(3), NOD1(9), PAK1(3), PLCG1(12), PLCG2(27), PTPN11(8), PTPRZ1(46), RAC1(1), RELA(6), SRC(3), TCIRG1(6), TJP1(24) 25714605 457 81 451 144 115 190 80 1 69 2 0.301 1.000 1.000 324 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(17), CARM1(5), CCND1(14), CREBBP(32), EP300(32), ERCC3(11), ESR1(11), GRIP1(12), GTF2A1(3), GTF2E1(3), GTF2F1(7), HDAC1(5), HDAC2(3), HDAC3(12), HDAC4(14), HDAC5(12), HDAC6(24), MEF2C(10), NCOR2(24), NR0B1(8), NRIP1(17), PELP1(9), POLR2A(21), TBP(3) 16878927 309 80 295 82 112 89 53 1 53 1 0.00855 1.000 1.000 325 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 48 ADORA3(4), ALG6(5), CCKBR(3), CCR2(5), CCR3(4), CCR5(6), CELSR1(24), CELSR2(22), CELSR3(26), CHRM2(10), CHRM3(8), CIDEB(2), CXCR3(5), EDNRA(5), EMR2(4), EMR3(3), F2R(6), FSHR(15), GHRHR(2), GNRHR(4), GPR116(21), GPR132(6), GPR133(15), GPR135(4), GPR143(4), GPR17(6), GPR18(3), GPR55(3), GPR56(3), GPR61(4), GPR84(3), GRM1(26), GRPR(4), HRH4(5), LGR6(12), LPHN2(22), LPHN3(21), LTB4R2(4), NTSR1(5), P2RY11(7), P2RY13(2), PTGFR(10), SMO(9), SSTR2(3), TAAR5(5), TSHR(8), VN1R1(5) 22229698 383 80 381 152 110 161 60 3 47 2 0.592 1.000 1.000 326 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(5), ACADL(8), ACADM(9), ACOX1(7), ACOX2(9), ACOX3(8), ACSL1(13), ACSL3(7), ACSL4(21), ACSL5(8), ACSL6(12), ADIPOQ(2), APOA1(3), APOA2(2), APOA5(2), APOC3(1), AQP7(3), CD36(8), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), CYP27A1(9), CYP4A11(7), CYP4A22(7), CYP7A1(11), CYP8B1(4), DBI(1), EHHADH(10), FABP1(4), FABP2(2), FABP3(1), FABP4(2), FABP5(3), FABP6(3), FABP7(1), FADS2(2), GK(17), GK2(20), HMGCS2(9), ILK(5), LPL(16), ME1(12), MMP1(4), NR1H3(4), OLR1(2), PCK1(9), PCK2(7), PDPK1(3), PLTP(7), PPARA(2), PPARD(3), PPARG(6), RXRA(3), RXRG(9), SCD(6), SCP2(10), SLC27A1(10), SLC27A2(3), SLC27A4(5), SLC27A5(3), SLC27A6(9), SORBS1(18), UBC(8), UCP1(2) 23302521 441 80 432 130 130 160 86 1 64 0 0.0629 1.000 1.000 327 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(2), CAD(25), CANT1(1), CDA(2), CTPS2(7), DCK(3), DCTD(5), DHODH(3), DPYD(20), DPYS(6), DTYMK(2), ENTPD1(4), ITPA(1), NME1(2), NME2(3), NT5C(1), NT5E(6), NT5M(2), NUDT2(2), POLB(4), POLD1(10), POLD2(6), POLE(47), POLG(6), POLL(6), POLQ(29), POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLRMT(11), RRM1(2), RRM2(6), TK1(3), TK2(6), TXNRD1(10), UCK1(5), UCK2(5), UMPS(6), UNG(3), UPB1(10), UPP1(4) 20573408 350 80 333 109 105 137 62 1 44 1 0.207 1.000 1.000 328 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(6), AASDHPPT(9), AASS(12), ACAT1(6), ACAT2(4), AKR1B10(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), BBOX1(1), DLST(8), DOT1L(8), ECHS1(3), EHHADH(10), EHMT1(23), EHMT2(2), GCDH(4), HADH(1), HADHA(5), HSD17B10(4), HSD17B4(12), HSD3B7(5), NSD1(36), OGDH(13), OGDHL(19), PIPOX(4), PLOD1(4), PLOD2(11), PLOD3(6), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SETD1A(12), SETD7(7), SETDB1(15), SHMT1(5), SHMT2(5), SPCS3(2), SUV39H1(7), SUV39H2(5), TMLHE(6) 20158536 323 79 312 114 115 107 63 9 28 1 0.507 1.000 1.000 329 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR1(4), AGTR2(11), ATP8A1(16), AVPR1A(7), AVPR1B(3), AVPR2(4), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), CCKAR(9), CCKBR(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CX3CR1(6), CXCR3(5), CXCR4(1), CXCR6(1), EDNRA(5), EDNRB(4), FPR1(2), FSHR(15), GALR1(3), GALR3(2), GALT(3), GHSR(8), GNB2L1(1), GNRHR(4), GRPR(4), LHCGR(17), MC1R(3), MC2R(4), MC3R(5), MC4R(5), MC5R(14), NMBR(4), NPY1R(9), NPY2R(5), NPY5R(13), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(11), OXTR(4), SSTR1(9), SSTR2(3), SSTR3(3), SSTR4(10), TACR1(7), TACR2(3), TACR3(9), TRHR(3), TSHR(8) 18351949 368 79 356 139 109 158 49 6 44 2 0.195 1.000 1.000 330 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(22), ATP4A(9), ATP4B(4), ATP5A1(8), ATP5B(5), ATP5C1(1), ATP5D(1), ATP5E(2), ATP5F1(4), ATP5G1(2), ATP5G2(1), ATP5G3(1), ATP5H(1), ATP5I(2), ATP5J(3), ATP5L(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), COX10(3), COX15(3), COX17(1), COX4I1(3), COX5A(1), COX5B(1), COX6A1(3), COX6A2(1), COX6B1(1), COX6C(3), COX7A1(3), COX7B(4), COX7B2(3), COX7C(2), COX8A(1), COX8C(1), CYC1(3), LHPP(2), NDUFA1(1), NDUFA10(6), NDUFA13(1), NDUFA2(3), NDUFA3(1), NDUFA4(1), NDUFA4L2(1), NDUFA5(1), NDUFA6(2), NDUFA8(5), NDUFA9(5), NDUFAB1(2), NDUFB1(1), NDUFB10(1), NDUFB11(3), NDUFB7(3), NDUFB8(2), NDUFC1(1), NDUFC2(1), NDUFS1(13), NDUFS2(7), NDUFS4(3), NDUFS5(1), NDUFS7(1), NDUFS8(3), NDUFV1(3), NDUFV2(2), PPA1(4), PPA2(5), SDHA(14), SDHB(2), SDHC(2), SDHD(3), TCIRG1(6), UQCRB(4), UQCRC1(2), UQCRC2(7), UQCRFS1(3), UQCRH(1), UQCRQ(2) 20433737 360 78 356 97 114 128 53 2 61 2 0.0141 1.000 1.000 331 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(6), AANAT(2), ACAT1(6), ACAT2(4), ACMSD(8), AFMID(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), AOC2(7), AOC3(10), AOX1(18), ASMT(5), CARM1(5), CAT(4), CYP1A1(11), CYP1A2(11), CYP1B1(2), DDC(8), ECHS1(3), EHHADH(10), GCDH(4), HAAO(2), HADH(1), HADHA(5), HEMK1(2), HSD17B10(4), HSD17B4(12), INMT(2), KMO(8), KYNU(7), LCMT1(2), LCMT2(9), LNX1(8), MAOA(12), MAOB(7), METTL2B(4), METTL6(4), NFX1(15), OGDH(13), OGDHL(19), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), TDO2(3), TPH1(9), TPH2(4), WARS(6), WARS2(3), WBSCR22(2) 21980296 356 78 345 109 106 135 70 6 37 2 0.122 1.000 1.000 332 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(17), AMY2A(4), AMY2B(12), ENPP1(12), ENPP3(17), G6PC(5), GAA(4), GANAB(10), GBE1(9), GCK(2), GPI(7), GUSB(5), GYS1(13), GYS2(16), HK1(11), HK2(9), HK3(9), MGAM(38), PGM1(6), PGM3(3), PYGB(11), PYGL(8), PYGM(10), RNPC3(6), SI(65), UCHL1(4), UGDH(2), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2B15(9), UGT2B4(11), UXS1(5) 21023868 385 76 380 96 89 142 90 5 59 0 0.0139 1.000 1.000 333 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), ALDH1A3(8), ALDH3A1(4), ALDH3B2(7), AOC2(7), AOC3(10), AOX1(18), CARM1(5), COMT(3), DBH(9), DCT(11), DDC(8), ECH1(2), ESCO1(16), ESCO2(8), FAH(6), GOT1(9), GOT2(3), GSTZ1(5), HEMK1(2), HGD(4), HPD(2), LCMT1(2), LCMT2(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(4), NAT6(1), PNMT(2), PNPLA3(7), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SH3GLB1(7), TAT(7), TH(3), TPO(14), TYR(12), TYRP1(7), WBSCR22(2) 21082149 312 74 307 94 90 113 59 4 46 0 0.120 1.000 1.000 334 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AGK(10), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), AKR1A1(1), AKR1B1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), CEL(5), DAK(4), DGAT1(3), DGAT2(6), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKI(18), DGKQ(2), DGKZ(10), GK(17), GK2(20), GLA(9), GLB1(6), GPAM(9), LCT(32), LIPA(8), LIPC(8), LIPF(6), LIPG(7), LPL(16), MGLL(2), PNLIP(6), PNLIPRP1(5), PNPLA3(7), PPAP2A(5), PPAP2B(3), PPAP2C(1) 21221405 376 74 369 130 116 138 77 3 40 2 0.346 1.000 1.000 335 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(6), ACTR2(6), ACTR3(1), AKT1(4), ANGPTL2(6), CDC42(3), CFL1(1), CFL2(8), FLNA(38), FLNC(37), FSCN1(5), FSCN3(5), GDI1(4), GDI2(1), LIMK1(8), MYH2(41), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PFN1(1), PFN2(2), RHO(4), ROCK1(22), ROCK2(17), RPS4X(1), VASP(3), WASF1(3), WASL(8) 16540338 292 74 289 89 88 117 42 3 37 5 0.0507 1.000 1.000 336 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(8), AGTR2(11), CALM1(2), CALM2(3), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CDK5(2), F2(8), FYN(5), GNA11(2), GNAI1(5), GNB1(2), GNGT1(1), GRB2(3), HRAS(1), JAK2(17), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(11), MAPT(9), MYLK(14), PLCG1(12), PRKCA(11), PTK2B(15), RAF1(9), SHC1(6), SOS1(13), STAT1(15), STAT3(11), STAT5A(5), SYT1(4) 15149973 244 73 235 84 82 84 43 1 31 3 0.433 1.000 1.000 337 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 37 ATF2(8), CDC42(3), CREB1(5), DAXX(9), DDIT3(2), ELK1(3), GRB2(3), HMGN1(2), HRAS(1), HSPB2(1), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K5(25), MAP3K7(9), MAP3K9(6), MAPK14(4), MAPKAPK2(5), MAPKAPK5(5), MAX(9), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), MKNK1(3), MYC(8), PLA2G4A(13), RAC1(1), RIPK1(8), RPS6KA5(11), SHC1(6), STAT1(15), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TRAF2(3) 13320121 259 73 250 65 71 96 48 1 42 1 0.0565 1.000 1.000 338 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(3), CDC7(11), CDK2(2), CDT1(1), DIAPH2(31), GMNN(2), MCM10(8), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), NACA(20), PCNA(3), POLA2(3), POLD1(10), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), PRIM1(3), RFC1(21), RFC2(4), RFC3(4), RFC4(5), RFC5(8), RPA1(6), RPA2(3), RPA3(3), RPA4(4), RPS27A(4), UBA52(1), UBB(2), UBC(8) 18401804 281 72 260 79 70 133 35 3 38 2 0.216 1.000 1.000 339 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(22), ATP4B(4), ATP5E(2), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), ATP7A(29), ATP7B(14), COX10(3), COX4I1(3), COX5A(1), COX5B(1), COX6A1(3), COX6A2(1), COX6B1(1), COX6C(3), COX7A1(3), COX7B(4), COX7C(2), COX8A(1), NDUFA1(1), NDUFA10(6), NDUFA4(1), NDUFA5(1), NDUFA8(5), NDUFB7(3), NDUFS1(13), NDUFS2(7), NDUFV1(3), NDUFV2(2), PPA2(5), SDHA(14), SDHB(2), SHMT1(5), UQCRB(4), UQCRC1(2), UQCRFS1(3), UQCRH(1) 14142139 273 72 269 70 76 103 38 2 52 2 0.0146 1.000 1.000 340 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT1(4), AKT2(6), AKT3(11), ARHGEF11(20), CDC42(3), DLG4(10), GNA13(7), IKBKG(3), LPA(14), MAP2K4(9), MAP3K1(30), MAP3K5(25), MAPK8(11), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), PDK1(2), PHKA2(21), PI3(2), PIK3CB(17), PLD1(13), PLD2(10), PLD3(5), PTK2(12), RDX(17), ROCK1(22), ROCK2(17), SERPINA4(4), SRF(3) 17689412 328 72 316 83 100 106 54 0 64 4 0.0353 1.000 1.000 341 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(8), AKT1(4), AKT2(6), AKT3(11), DAG1(6), GNAQ(3), IKBKG(3), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), PDK1(2), PHKA2(21), PIK3CB(17), PITX2(8), PLD1(13), PLD2(10), PLD3(5), VN1R1(5) 16052704 255 72 247 94 81 98 32 1 42 1 0.585 1.000 1.000 342 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(12), ADCY6(14), ADCY8(22), CACNA1A(19), CACNA1B(31), GNAS(24), GNAT3(8), GNB1(2), GNB3(2), GNG13(2), GNG3(2), GRM4(11), ITPR3(22), KCNB1(13), PDE1A(14), PLCB2(8), PRKACA(6), PRKACB(3), PRKACG(9), PRKX(2), SCNN1A(3), SCNN1B(4), SCNN1G(9), TAS1R1(10), TAS1R2(11), TAS1R3(4), TAS2R1(4), TAS2R10(9), TAS2R13(3), TAS2R14(6), TAS2R16(4), TAS2R3(4), TAS2R38(5), TAS2R39(9), TAS2R4(3), TAS2R40(5), TAS2R41(4), TAS2R42(4), TAS2R43(1), TAS2R46(2), TAS2R5(4), TAS2R50(4), TAS2R60(6), TAS2R7(3), TAS2R8(6), TAS2R9(3), TRPM5(8) 20433711 364 71 357 143 120 134 67 2 40 1 0.702 1.000 1.000 343 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(8), DAXX(9), EGF(19), EGFR(12), ETS1(6), ETS2(6), FOS(3), HOXA7(8), HRAS(1), IKBKB(13), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K5(25), MAPK1(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(11), NFKB1(10), NFKBIA(3), PPP2CA(6), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), RAF1(9), RELA(6), RIPK1(8), SP1(7), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3) 17531738 308 71 300 91 85 108 56 1 57 1 0.115 1.000 1.000 344 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(5), AKT1(4), BDKRB2(8), CALM1(2), CALM2(3), CAV1(2), CHRM1(6), CHRNA1(7), FLT1(20), FLT4(8), KDR(26), NOS3(11), PDE2A(14), PDE3A(19), PDE3B(15), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKG1(11), PRKG2(11), RYR2(109), SLC7A1(8), SYT1(4), TNNI1(1) 14841596 321 71 313 112 92 115 61 3 45 5 0.435 1.000 1.000 345 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AGPAT2(2), AGPAT3(4), AGPAT4(5), AKR1A1(1), AKR1B1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), CEL(5), DGAT1(3), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKQ(2), DGKZ(10), GK(17), GLA(9), GLB1(6), LCT(32), LIPC(8), LIPF(6), LIPG(7), LPL(16), PNLIP(6), PNLIPRP1(5), PPAP2A(5), PPAP2B(3), PPAP2C(1) 17350704 306 70 303 100 92 110 67 3 33 1 0.191 1.000 1.000 346 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 58 A4GALT(2), B3GALNT1(6), B3GALT1(12), B3GALT2(8), B3GALT4(3), B3GALT5(4), B3GNT1(5), B3GNT2(1), B3GNT3(5), B3GNT4(4), B3GNT5(6), B4GALNT1(6), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), B4GALT6(6), FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), FUT7(2), FUT9(9), GBGT1(6), GCNT2(4), PIGA(8), PIGB(11), PIGC(3), PIGF(2), PIGG(6), PIGH(5), PIGK(9), PIGL(1), PIGM(1), PIGN(13), PIGO(9), PIGP(3), PIGQ(5), PIGS(1), PIGT(8), PIGU(2), PIGV(7), PIGX(2), PIGZ(5), ST3GAL1(2), ST3GAL2(6), ST3GAL3(6), ST3GAL4(3), ST3GAL5(4), ST3GAL6(6), ST6GALNAC3(8), ST6GALNAC4(4), ST6GALNAC5(2), ST6GALNAC6(6), ST8SIA1(2), ST8SIA5(8), UGCG(4) 16968686 297 70 290 74 101 107 51 2 36 0 0.00245 1.000 1.000 347 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(29), POLA2(3), POLB(4), POLD1(10), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLG(6), POLG2(3), POLH(12), POLI(6), POLK(11), POLL(6), POLM(6), POLQ(29), PRIM1(3), REV1(14), REV3L(35), RFC5(8) 14833216 253 70 234 61 58 106 43 3 42 1 0.0990 1.000 1.000 348 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(6), ACTR3(1), ARHGAP1(2), ARHGAP4(10), ARHGAP5(21), ARHGAP6(18), ARHGEF1(12), ARHGEF11(20), ARHGEF5(13), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(5), CFL1(1), DIAPH1(12), GSN(4), LIMK1(8), MYL2(2), MYLK(14), OPHN1(19), PFN1(1), PIP5K1A(8), PIP5K1B(5), PPP1R12B(19), ROCK1(22), SRC(3), TLN1(23), VCL(11) 16688465 274 70 267 83 97 95 46 0 33 3 0.225 1.000 1.000 349 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(7), AARS2(6), CARS(8), CARS2(5), DARS(7), DARS2(10), EARS2(5), EPRS(15), FARS2(2), FARSA(6), FARSB(7), GARS(8), HARS(5), HARS2(7), IARS(8), IARS2(20), KARS(5), LARS(18), LARS2(8), MARS(11), MARS2(4), NARS(10), NARS2(10), PARS2(4), QARS(7), RARS(13), RARS2(8), SARS(4), SARS2(4), TARS(9), TARS2(9), VARS(6), VARS2(1), WARS(6), WARS2(3), YARS(5), YARS2(3) 19060344 274 69 269 89 80 105 50 3 36 0 0.672 1.000 1.000 350 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRA2A(6), ADRA2C(2), ADRB2(7), ADRB3(3), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), DRD1(6), DRD2(8), DRD3(6), DRD5(11), HRH1(10), HRH2(4), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(16), HTR4(6), HTR5A(12), HTR6(4), HTR7(5) 8984624 228 69 220 83 89 83 42 3 11 0 0.0982 1.000 1.000 351 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(18), AR(12), ESR1(11), ESR2(5), ESRRA(2), HNF4A(12), NPM1(2), NR0B1(8), NR1D1(4), NR1D2(2), NR1H2(3), NR1H3(4), NR1I2(3), NR1I3(4), NR2C2(7), NR2E1(8), NR2F1(7), NR2F2(5), NR2F6(4), NR3C1(17), NR4A1(6), NR4A2(11), NR5A1(3), NR5A2(13), PGR(13), PPARA(2), PPARD(3), PPARG(6), RARA(2), RARB(3), RARG(6), ROR1(10), RORA(6), RORC(8), RXRA(3), RXRG(9), THRA(4), THRB(4), VDR(8) 14380270 258 69 248 79 95 87 44 3 28 1 0.102 1.000 1.000 352 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(5), ACSS2(5), ACYP1(2), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1A1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH3B2(7), ALDH7A1(1), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), G6PC2(11), GALM(1), GAPDH(2), GAPDHS(10), GCK(2), GPI(7), HK1(11), HK2(9), HK3(9), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(5), PDHA1(7), PDHA2(9), PDHB(3), PFKL(8), PFKM(8), PFKP(8), PGAM1(3), PGAM2(1), PGAM4(5), PGK1(7), PGK2(6), PGM1(6), PGM3(3), PKLR(6), TPI1(2) 20778184 293 68 290 107 92 111 52 2 36 0 0.564 1.000 1.000 353 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(4), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), CDS1(5), CHAT(5), CHKA(9), CHKB(6), CHPT1(1), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKI(18), DGKQ(2), DGKZ(10), ESCO1(16), ESCO2(8), ETNK1(9), ETNK2(3), GNPAT(11), GPAM(9), GPD1(3), GPD1L(4), GPD2(3), LCAT(4), LYPLA1(1), LYPLA2(7), NAT6(1), PCYT1A(3), PCYT1B(4), PEMT(1), PISD(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLD1(13), PLD2(10), PNPLA3(7), PPAP2A(5), PPAP2B(3), PPAP2C(1), PTDSS1(5), PTDSS2(2), SH3GLB1(7) 23545860 340 68 336 129 104 119 67 3 45 2 0.857 1.000 1.000 354 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(56), CDH1(14), CREBBP(32), EP300(32), MAP2K1(2), MAP3K7(9), MAPK3(3), SKIL(7), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6) 9444442 182 68 173 48 48 61 36 2 31 4 0.182 1.000 1.000 355 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(3), BAG4(5), CASP2(6), CASP3(4), CASP8(21), CRADD(3), DFFB(4), FADD(1), JUN(1), LMNA(7), LMNB1(5), LMNB2(4), MADD(16), MAP2K4(9), MAP3K1(30), MAP3K7(9), MAPK8(11), PAK1(3), PAK2(3), PRKDC(54), RB1(26), RIPK1(8), SPTAN1(31), TNFRSF1A(4), TRAF2(3) 14248497 271 68 263 82 74 78 52 4 59 4 0.466 1.000 1.000 356 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(8), AGTR1(4), ATF2(8), CALM1(2), CALM2(3), EGFR(12), ELK1(3), GNAQ(3), GRB2(3), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(11), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), PAK1(3), PRKCA(11), PTK2(12), PTK2B(15), RAC1(1), RAF1(9), SHC1(6), SOS1(13), SRC(3), SYT1(4) 12424151 208 67 201 62 58 76 40 0 33 1 0.227 1.000 1.000 357 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(4), BTK(12), CALM1(2), CALM2(3), CD79A(1), CD79B(2), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP3K1(30), MAPK14(4), MAPK3(3), MAPK8(11), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKCA(11), RAC1(1), RAF1(9), SHC1(6), SOS1(13), SYK(4), SYT1(4), VAV1(12) 13601950 221 67 213 67 64 77 47 1 31 1 0.262 1.000 1.000 358 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(3), CASP10(8), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CFLAR(2), DAXX(9), DFFB(4), FADD(1), FAF1(10), JUN(1), LMNA(7), LMNB1(5), LMNB2(4), MAP2K4(9), MAP3K1(30), MAP3K7(9), MAPK8(11), PAK1(3), PAK2(3), PRKDC(54), PTPN13(29), RB1(26), RIPK2(6), SPTAN1(31) 15656179 298 67 289 80 75 95 55 4 64 5 0.257 1.000 1.000 359 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(8), CALM1(2), CALM2(3), CRKL(6), GNAQ(3), GRB2(3), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(11), PAK1(3), PLCG1(12), PRKCA(11), PTK2B(15), RAC1(1), RAF1(9), SHC1(6), SOS1(13), SRC(3), SYT1(4) 10198568 177 67 170 54 50 62 35 0 29 1 0.335 1.000 1.000 360 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ACAT1(6), ACAT2(4), ACMSD(8), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), AOC2(7), AOC3(10), AOX1(18), ASMT(5), CAT(4), CYP19A1(13), CYP1A1(11), CYP1A2(11), CYP2A13(9), CYP2A6(13), CYP2A7(6), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(5), CYP3A4(10), CYP3A5(6), CYP3A7(5), CYP4B1(4), CYP51A1(4), DDC(8), ECHS1(3), EHHADH(10), GCDH(4), HAAO(2), HADHA(5), KMO(8), KYNU(7), MAOA(12), MAOB(7), SDS(1), TDO2(3), TPH1(9), WARS(6), WARS2(3) 20087936 341 67 335 110 95 133 66 4 40 3 0.269 1.000 1.000 361 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1C1(6), AKR1C2(3), AKR1C3(2), AKR1C4(6), ALDH1A3(8), ALDH3A1(4), ALDH3B2(7), CYP1A1(11), CYP1A2(11), CYP1B1(2), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2F1(4), CYP2S1(8), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(5), DHDH(4), EPHX1(2), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTA5(4), GSTK1(5), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), MGST1(4), MGST3(2), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2A1(9), UGT2A3(5), UGT2B10(18), UGT2B11(8), UGT2B15(9), UGT2B17(7), UGT2B28(15), UGT2B4(11), UGT2B7(5) 20623799 356 66 344 93 95 144 68 3 46 0 0.0146 1.000 1.000 362 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(5), ACTN1(9), ACTN2(16), BCAR1(8), BCR(6), CAPN1(5), CAPNS1(2), CAPNS2(3), CAV1(2), CRKL(6), CSK(1), FYN(5), GRB2(3), HRAS(1), ITGA1(17), ITGB1(8), JUN(1), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MAPK8(11), PPP1R12B(19), PTK2(12), PXN(6), RAF1(9), RAP1A(4), ROCK1(22), SHC1(6), SOS1(13), SRC(3), TLN1(23), VCL(11), ZYX(11) 16913420 260 66 252 70 93 84 47 0 34 2 0.0192 1.000 1.000 363 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(4), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPS(8), CDS1(5), CHAT(5), CHKA(9), CHKB(6), CLC(1), CPT1B(6), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKQ(2), DGKZ(10), ETNK1(9), GNPAT(11), GPD1(3), GPD2(3), LCAT(4), LGALS13(1), LYPLA1(1), LYPLA2(7), PAFAH1B1(3), PAFAH2(2), PCYT1A(3), PCYT1B(4), PEMT(1), PISD(2), PLA2G2E(5), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB2(8), PLCG1(12), PLCG2(27), PPAP2A(5), PPAP2B(3), PPAP2C(1) 17808076 288 65 283 106 91 99 60 3 32 3 0.716 1.000 1.000 364 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(5), ALDOB(9), ALDOC(3), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(2), GAPDHS(10), GCK(2), GOT1(9), GOT2(3), GPI(7), HK1(11), HK2(9), HK3(9), LDHA(6), LDHAL6B(2), LDHB(3), LDHC(5), MDH1(2), MDH2(4), PC(12), PCK1(9), PDHA1(7), PDHA2(9), PDHB(3), PDHX(11), PFKL(8), PFKM(8), PFKP(8), PGAM1(3), PGAM2(1), PGK1(7), PGK2(6), PKLR(6), TNFAIP1(3), TPI1(2) 15179743 235 65 232 82 77 85 41 2 30 0 0.383 1.000 1.000 365 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(2), ALOX12(8), ALOX12B(10), ALOX15(9), ALOX15B(6), ALOX5(10), CBR1(3), CBR3(2), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2J2(5), CYP2U1(2), CYP4A11(7), CYP4A22(7), CYP4F2(12), CYP4F3(8), EPHX2(7), GGT1(5), GPX2(1), GPX5(6), GPX6(7), GPX7(1), LTA4H(4), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PTGDS(4), PTGES(2), PTGES2(3), PTGIS(7), PTGS1(5), PTGS2(9), TBXAS1(7) 14108848 243 65 235 71 87 83 37 5 31 0 0.0700 1.000 1.000 366 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(31), ACACB(29), ACAT1(6), ACAT2(4), ACOT12(11), ACSS1(5), ACSS2(5), ACYP1(2), AKR1B1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), DLAT(3), DLD(5), GRHPR(2), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(5), LDHD(2), MDH1(2), MDH2(4), ME1(12), ME2(8), ME3(9), PC(12), PCK1(9), PCK2(7), PDHA1(7), PDHA2(9), PDHB(3), PKLR(6) 16736435 245 65 238 89 76 89 40 5 33 2 0.659 1.000 1.000 367 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(3), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH4A1(4), ALDH9A1(2), AMD1(3), AOC2(7), AOC3(10), ARG1(5), ARG2(3), ASL(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(22), DAO(8), GAMT(3), GATM(5), GLUD1(3), GOT1(9), GOT2(3), MAOA(12), MAOB(7), NOS1(18), NOS3(11), OAT(7), ODC1(2), OTC(7), P4HA1(6), P4HA2(12), P4HA3(3), P4HB(5), PYCR1(3), RARS(13), SMS(8) 15728089 259 64 254 88 84 91 47 6 29 2 0.380 1.000 1.000 368 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(2), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1A1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(2), GCK(2), GPI(7), HK1(11), HK2(9), HK3(9), LDHA(6), LDHB(3), LDHC(5), PDHA1(7), PDHA2(9), PDHB(3), PFKM(8), PFKP(8), PGAM1(3), PGK1(7), PGM1(6), PGM3(3), PKLR(6), TPI1(2) 17484356 251 64 249 87 76 91 45 2 37 0 0.406 1.000 1.000 369 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(4), AGXT2(13), ALAS1(8), ALAS2(10), AMT(2), AOC2(7), AOC3(10), ATP6V0C(1), BHMT(2), CBS(11), CHDH(2), CHKA(9), CHKB(6), CPT1B(6), CTH(6), DAO(8), DLD(5), DMGDH(4), GAMT(3), GARS(8), GATM(5), GLDC(16), MAOA(12), MAOB(7), PEMT(1), PISD(2), PLCB2(8), PLCG1(12), PLCG2(27), PSPH(1), SARDH(8), SARS(4), SHMT1(5), SHMT2(5), TARS(9) 15209542 247 64 239 82 77 91 45 0 34 0 0.376 1.000 1.000 370 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(2), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1A1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(2), GCK(2), GPI(7), HK1(11), HK2(9), HK3(9), LDHA(6), LDHB(3), LDHC(5), PDHA1(7), PDHA2(9), PDHB(3), PFKM(8), PFKP(8), PGAM1(3), PGK1(7), PGM1(6), PGM3(3), PKLR(6), TPI1(2) 17484356 251 64 249 87 76 91 45 2 37 0 0.406 1.000 1.000 371 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), AKR1B10(4), B4GALT1(2), B4GALT2(5), G6PC(5), G6PC2(11), GAA(4), GALK1(1), GALK2(3), GALT(3), GANC(15), GCK(2), GLA(9), GLB1(6), HK1(11), HK2(9), HK3(9), HSD3B7(5), LALBA(2), LCT(32), MGAM(38), PFKL(8), PFKM(8), PFKP(8), PGM1(6), PGM3(3), RDH11(1), RDH12(5), RDH13(4), RDH14(2), UGP2(6) 13671150 228 64 224 81 73 80 42 3 30 0 0.503 1.000 1.000 372 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(7), AARS2(6), ABAT(9), ACY3(3), ADSL(8), ADSS(6), ADSSL1(5), AGXT(4), AGXT2(13), ASL(2), ASNS(9), ASPA(5), ASS1(1), CAD(25), CRAT(3), DARS(7), DARS2(10), DDO(7), DLAT(3), DLD(5), GAD1(6), GAD2(12), GOT1(9), GOT2(3), GPT(2), GPT2(5), NARS(10), NARS2(10), PC(12), PDHA1(7), PDHA2(9), PDHB(3) 13551574 226 64 220 78 52 88 37 5 44 0 0.554 1.000 1.000 373 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(9), ACAA1(5), ACAA2(3), ACADM(9), ACADS(3), ACAT1(6), ACAT2(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH6A1(6), ALDH7A1(1), ALDH9A1(2), AOX1(18), AUH(4), BCAT1(7), BCAT2(3), BCKDHA(5), BCKDHB(4), DBT(5), DLD(5), ECHS1(3), EHHADH(10), HADH(1), HADHA(5), HADHB(4), HIBADH(5), HIBCH(6), HMGCL(2), HMGCS1(6), HMGCS2(9), HSD17B10(4), HSD17B4(12), IVD(2), MCCC1(8), MCCC2(5), MCEE(1), MUT(10), OXCT1(10), OXCT2(2), PCCA(6), PCCB(8) 15810646 242 64 238 71 60 95 54 2 31 0 0.209 1.000 1.000 374 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), ASCC3(31), ATP13A2(5), DDX18(12), DDX19A(4), DDX23(9), DDX4(15), DDX41(3), DDX47(5), DDX50(10), DDX51(8), DDX52(4), DDX54(8), DDX55(6), DDX56(5), DHFR(4), DHX58(6), ENTPD7(8), EP400(42), ERCC2(1), ERCC3(11), FPGS(5), GCH1(1), GGH(2), IFIH1(5), MOV10L1(19), NUDT5(2), NUDT8(1), PTS(1), RAD54B(14), RAD54L(6), RUVBL2(4), SETX(33), SKIV2L2(17), SMARCA2(24), SMARCA5(19), SPR(1) 22546741 366 64 351 97 125 111 81 4 39 6 0.0231 1.000 1.000 375 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 28 AGA(7), ARSB(5), FUCA1(3), FUCA2(4), GALNS(4), GBA(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), HGSNAT(10), HPSE(6), HPSE2(11), HYAL1(2), HYAL2(4), IDS(8), IDUA(5), LCT(32), MAN2B1(14), MAN2B2(5), MAN2C1(7), MANBA(12), NAGLU(3), NEU2(4), NEU3(3), SPAM1(15) 11933424 192 64 191 77 49 82 36 3 22 0 0.871 1.000 1.000 376 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(39), B3GALT4(3), CDR1(2), DGKI(18), IL6ST(11), MRPL19(6), PIGK(9), RPL10(4), RPL11(3), RPL13(1), RPL13A(1), RPL14(2), RPL15(2), RPL17(6), RPL18(1), RPL18A(2), RPL19(4), RPL21(3), RPL22(5), RPL23(1), RPL24(2), RPL27(1), RPL27A(3), RPL28(2), RPL29(2), RPL3(2), RPL34(1), RPL35A(2), RPL37(2), RPL38(1), RPL39(4), RPL3L(3), RPL4(4), RPL5(7), RPL6(3), RPL7(1), RPL7A(2), RPL8(2), RPL9(2), RPLP0(5), RPS10(1), RPS11(1), RPS12(2), RPS13(1), RPS15(1), RPS16(1), RPS18(3), RPS2(1), RPS20(3), RPS21(1), RPS24(2), RPS25(2), RPS27(1), RPS27A(4), RPS28(1), RPS29(2), RPS3(3), RPS3A(1), RPS4X(1), RPS6(7), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA6(19), RPS6KB1(3), RPS6KB2(4), RPS7(5), RPS8(2), RPSA(1), SLC36A2(6), TBC1D10C(1), TSPAN9(4), UBA52(1), UBB(2), UBC(8) 19078569 302 63 293 114 83 111 62 2 41 3 0.983 1.000 1.000 377 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), AKR1B10(4), ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), FPGT(6), FUK(8), GMDS(4), GMPPA(4), GMPPB(2), HK1(11), HK2(9), HK3(9), HSD3B7(5), KHK(2), LHPP(2), MPI(5), MTMR1(16), MTMR2(5), MTMR6(10), PFKFB1(8), PFKFB2(4), PFKFB3(4), PFKFB4(4), PFKL(8), PFKM(8), PFKP(8), PGM2(8), PHPT1(1), PMM2(6), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SORD(5), TPI1(2), TSTA3(3) 13401284 204 62 199 78 75 60 35 2 32 0 0.658 1.000 1.000 378 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(6), AKR1D1(8), ARSD(5), ARSE(10), CARM1(5), CYP11B1(8), CYP11B2(8), CYP19A1(13), HEMK1(2), HSD11B1(6), HSD17B1(4), HSD17B12(4), HSD17B2(2), HSD17B3(7), HSD17B7(5), HSD17B8(2), HSD3B1(3), HSD3B2(6), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(4), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SRD5A1(4), STS(8), SULT1E1(9), SULT2A1(7), SULT2B1(4), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2A1(9), UGT2A3(5), UGT2B10(18), UGT2B11(8), UGT2B15(9), UGT2B17(7), UGT2B28(15), UGT2B4(11), UGT2B7(5), WBSCR22(2) 17574364 325 62 313 102 71 149 52 3 48 2 0.233 1.000 1.000 379 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(9), ALDH4A1(4), ALDH5A1(7), CAD(25), CPS1(22), EARS2(5), EPRS(15), GAD1(6), GAD2(12), GCLC(8), GCLM(2), GFPT1(9), GFPT2(12), GLS(11), GLS2(7), GLUD1(3), GLUD2(9), GLUL(7), GMPS(14), GNPNAT1(2), GOT1(9), GOT2(3), GPT(2), GPT2(5), GSR(6), GSS(5), NADSYN1(6), NAGK(2), PPAT(9), QARS(7) 14398876 243 62 237 76 73 77 47 4 40 2 0.284 1.000 1.000 380 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(5), ACAA2(3), ACADL(8), ACADM(9), ACADS(3), ACADSB(6), ACADVL(9), ACAT1(6), ACAT2(4), ACOX1(7), ACOX3(8), ACSL1(13), ACSL3(7), ACSL4(21), ACSL5(8), ACSL6(12), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), CYP4A11(7), CYP4A22(7), ECHS1(3), EHHADH(10), GCDH(4), HADH(1), HADHA(5), HADHB(4), HSD17B10(4), HSD17B4(12) 17830726 276 61 270 82 79 94 61 2 40 0 0.105 1.000 1.000 381 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(4), AGXT2(13), AKR1B10(4), ALAS1(8), ALAS2(10), AMT(2), AOC2(7), AOC3(10), BHMT(2), CBS(11), CHDH(2), CHKA(9), CHKB(6), CTH(6), DAO(8), DLD(5), DMGDH(4), GAMT(3), GARS(8), GATM(5), GLDC(16), GNMT(3), HSD3B7(5), MAOA(12), MAOB(7), PEMT(1), PHGDH(5), PIPOX(4), PISD(2), PSAT1(5), PSPH(1), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SARDH(8), SARS(4), SARS2(4), SDS(1), SHMT1(5), SHMT2(5), TARS(9), TARS2(9) 15514922 245 61 238 91 76 93 42 1 33 0 0.676 1.000 1.000 382 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(6), ALG10B(6), ALG11(6), ALG12(6), ALG13(24), ALG14(2), ALG2(2), ALG5(2), ALG6(5), ALG8(11), ALG9(2), B4GALT1(2), B4GALT2(5), B4GALT3(10), DAD1(2), DDOST(3), DHDDS(4), DOLPP1(2), DPAGT1(3), DPM1(2), FUT8(10), GANAB(10), MAN1A1(13), MAN1A2(7), MAN1B1(5), MAN1C1(6), MAN2A1(20), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), MGAT5B(10), RFT1(6), RPN1(3), RPN2(5), ST6GAL1(7), STT3B(5) 15130995 248 61 235 66 80 80 53 1 33 1 0.0523 1.000 1.000 383 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(9), ACACA(31), ACACB(29), ACADM(9), ACAT1(6), ACAT2(4), ACSS1(5), ACSS2(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH6A1(6), ALDH7A1(1), ALDH9A1(2), ECHS1(3), EHHADH(10), HADHA(5), HIBCH(6), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(5), MCEE(1), MLYCD(3), MUT(10), PCCA(6), PCCB(8), SUCLA2(5), SUCLG1(5), SUCLG2(10) 14485204 227 61 222 63 59 83 51 5 27 2 0.121 1.000 1.000 384 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(7), AADAC(6), ABAT(9), ACADS(3), ACAT1(6), ACAT2(4), ACSM1(12), AKR1B10(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH5A1(7), ALDH7A1(1), ALDH9A1(2), BDH1(3), BDH2(4), DDHD1(9), ECHS1(3), EHHADH(10), GAD1(6), GAD2(12), HADH(1), HADHA(5), HMGCL(2), HMGCS1(6), HMGCS2(9), HSD17B10(4), HSD17B4(12), HSD3B7(5), ILVBL(8), L2HGDH(5), OXCT1(10), OXCT2(2), PDHA1(7), PDHA2(9), PDHB(3), PLA1A(6), PPME1(3), PRDX6(4), RDH11(1), RDH12(5), RDH13(4), RDH14(2) 14787189 245 61 236 77 75 83 46 6 34 1 0.199 1.000 1.000 385 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A1L(6), GTF2B(5), GTF2E1(3), GTF2E2(2), GTF2F1(7), GTF2F2(1), GTF2H1(9), GTF2H3(3), GTF2H4(3), GTF2I(4), GTF2IRD1(7), STON1(6), TAF1(58), TAF10(1), TAF1L(40), TAF2(19), TAF4(10), TAF4B(4), TAF5(8), TAF5L(5), TAF6(9), TAF6L(5), TAF7(4), TAF7L(10), TAF9(4), TAF9B(12), TBPL1(5), TBPL2(5) 12968048 258 61 251 65 84 95 47 2 29 1 0.0810 1.000 1.000 386 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(12), ADRBK2(15), ARRB2(5), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CLCA1(15), CLCA2(10), CLCA4(15), CNGA3(13), CNGA4(9), CNGB1(13), GNAL(6), GUCA1A(4), GUCA1B(2), GUCA1C(4), PDC(1), PDE1C(11), PRKACA(6), PRKACB(3), PRKACG(9), PRKG1(11), PRKG2(11), PRKX(2) 11219988 212 61 208 70 61 81 33 2 33 2 0.335 1.000 1.000 387 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(8), ALOX15(9), ALOX5(10), CBR1(3), CBR3(2), CYP4F2(12), CYP4F3(8), EPX(15), GGT1(5), LPO(6), LTA4H(4), MPO(8), PLA2G2E(5), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PRDX2(2), PRDX5(1), PRDX6(4), PTGDS(4), PTGES2(3), PTGIS(7), PTGS1(5), PTGS2(9), TBXAS1(7), TPO(14) 10064017 183 61 175 61 75 57 26 5 20 0 0.275 1.000 1.000 388 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(5), ARG2(3), ASL(2), ASS1(1), CKM(3), CKMT1A(1), CKMT2(4), CPS1(22), DAO(8), EPRS(15), GAMT(3), GATM(5), GLUD1(3), GLUD2(9), GOT1(9), GOT2(3), LAP3(10), NOS1(18), NOS3(11), OAT(7), OTC(7), P4HA1(6), P4HA2(12), P4HA3(3), PARS2(4), PRODH(10), PYCR1(3), PYCR2(2), PYCRL(1), RARS(13), RARS2(8) 12782303 215 60 211 82 67 79 38 5 24 2 0.810 1.000 1.000 389 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(8), CREBBP(32), DUSP1(2), EP300(32), IKBKB(13), IL1B(2), MAP2K3(7), MAP2K6(10), MAP3K7(9), MAPK11(3), MAPK14(4), MYD88(2), NFKB1(10), NFKBIA(3), NR3C1(17), RELA(6), TGFBR1(6), TGFBR2(6), TLR2(16) 10691056 188 60 181 49 53 59 41 1 33 1 0.109 1.000 1.000 390 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(8), BCR(6), BLNK(4), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8IP3(9), PAPPA(27), RAC1(1), RPS6KA1(1), RPS6KA3(19), SHC1(6), SOS1(13), SYK(4), VAV1(12), VAV2(7), VAV3(13) 11251667 187 60 181 57 51 69 38 1 27 1 0.270 1.000 1.000 391 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 34 AKT1(4), ATF1(6), CDC42(3), CREB1(5), CREB5(5), DUSP1(2), DUSP10(5), EEF2K(11), EIF4E(1), ELK1(3), IL1R1(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K10(7), MAP3K4(21), MAP3K5(25), MAP3K7(9), MAPK1(2), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPKAPK2(5), MAPKAPK5(5), MKNK1(3), MKNK2(2), MYEF2(7), NFKB1(10), NR2C2(7), SRF(3), TRAF6(7) 11929413 202 60 199 60 67 69 39 1 26 0 0.202 1.000 1.000 392 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(17), BAD(1), BAX(2), BCL2L1(4), BCL2L2(2), BOK(2), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CD40(1), CD40LG(6), CRADD(3), CYCS(2), DAXX(9), DFFB(4), FADD(1), FAS(8), FASLG(7), IKBKE(4), LTA(3), MCL1(1), NFKB1(10), NFKBIA(3), NGFR(3), NR3C1(17), NTRK1(13), PTPN13(29), RIPK1(8), TFG(4), TNFRSF1A(4), TNFRSF1B(2), TRAF1(5), TRAF2(3), TRAF3(5), TRAF6(7) 15655494 253 59 247 80 58 96 47 2 49 1 0.493 1.000 1.000 393 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(12), ELK1(3), GNAS(24), GNB1(2), GNGT1(1), GRB2(3), HRAS(1), IGF1R(13), ITGB1(8), KLK2(2), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(2), MYC(8), NGFR(3), PDGFRA(24), PPP2CA(6), PTPRR(17), RAF1(9), RPS6KA1(1), RPS6KA5(11), SHC1(6), SOS1(13), SRC(3), STAT3(11) 11799432 199 59 190 49 53 74 43 1 27 1 0.0232 1.000 1.000 394 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), DAG1(6), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), NFAT5(16), PDE6A(10), PDE6B(5), PDE6C(12), PDE6D(2), PDE6G(1), PDE6H(1), SLC6A13(8), TF(13) 13059603 200 59 198 69 56 85 24 1 32 2 0.318 1.000 1.000 395 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(12), F11(15), F12(2), F13B(15), F2(8), F5(47), F7(2), F8(45), F9(14), FGA(26), FGB(7), FGG(9), LPA(14), PLAT(6), PLG(14), SERPINB2(9), SERPINE1(5), SERPINF2(4), VWF(25) 12712243 279 58 263 79 65 127 50 0 36 1 0.133 1.000 1.000 396 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CALM2(3), CAMK1(3), CAMK1G(5), ELK1(3), FPR1(2), GNA15(1), GNB1(2), GNGT1(1), HRAS(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(2), NCF2(8), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NFKB1(10), NFKBIA(3), PAK1(3), PIK3C2G(16), PLCB1(5), PPP3CA(4), PPP3CB(6), PPP3CC(6), RAC1(1), RAF1(9), RELA(6), SYT1(4) 13841989 208 58 203 69 60 72 40 2 33 1 0.448 1.000 1.000 397 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CALR(3), CANX(4), CD4(6), CD74(1), CD8A(2), CD8B(1), CIITA(15), CREB1(5), CTSS(4), HLA-A(1), HLA-B(2), HLA-C(2), HLA-DMA(3), HLA-DOA(2), HLA-DOB(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), HSP90AA1(7), HSP90AB1(21), HSPA5(6), IFI30(1), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), KIR2DL3(1), KIR3DL1(10), KIR3DL2(5), KIR3DL3(3), KLRC1(7), KLRC2(1), KLRC3(2), KLRC4(5), KLRD1(3), LGMN(7), LTA(3), NFYA(9), NFYB(2), NFYC(3), PDIA3(5), PSME1(1), PSME2(3), RFX5(8), RFXANK(4), RFXAP(2), TAP1(8), TAP2(1), TAPBP(4) 15021381 234 58 225 65 60 104 38 0 30 2 0.0583 1.000 1.000 398 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(7), ABAT(9), ADSL(8), ADSS(6), AGXT(4), AGXT2(13), ASL(2), ASNS(9), ASPA(5), CAD(25), CRAT(3), DARS(7), DDO(7), GAD1(6), GAD2(12), GOT1(9), GOT2(3), GPT(2), GPT2(5), NARS(10), PC(12) 9296781 164 57 160 52 41 59 27 4 33 0 0.306 1.000 1.000 399 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(2), B4GALT2(5), FBP2(1), G6PC(5), GAA(4), GALK1(1), GALK2(3), GALT(3), GANAB(10), GCK(2), GLA(9), GLB1(6), HK1(11), HK2(9), HK3(9), LALBA(2), LCT(32), MGAM(38), PFKM(8), PFKP(8), PGM1(6), PGM3(3) 11638492 178 57 175 73 54 65 32 2 25 0 0.865 1.000 1.000 400 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(11), ACO1(17), ACO2(7), CLYBL(6), CS(6), DLD(5), DLST(8), FH(8), IDH1(4), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(9), MDH1(2), MDH2(4), OGDH(13), OGDHL(19), PC(12), PCK1(9), PCK2(7), SDHA(14), SDHB(2), SDHC(2), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(10) 10928355 199 57 195 71 79 60 35 4 21 0 0.387 1.000 1.000 401 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(2), C1GALT1(2), C1GALT1C1(6), GALNT1(10), GALNT10(8), GALNT11(12), GALNT12(6), GALNT13(18), GALNT14(6), GALNT2(10), GALNT3(8), GALNT4(8), GALNT5(5), GALNT6(1), GALNT7(12), GALNT8(11), GALNT9(8), GALNTL5(11), GCNT1(5), GCNT3(5), GCNT4(1), OGT(17), ST3GAL1(2), ST3GAL2(6), ST6GALNAC1(4), WBSCR17(15) 11810588 199 57 195 64 56 73 40 1 28 1 0.516 1.000 1.000 402 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(54), BMPR1B(6), CCND2(9), CDK4(2), CDKN1B(7), DAZL(6), DMC1(5), EGR1(6), ESR2(5), FSHR(15), GJA4(1), INHA(1), LHCGR(17), MLH1(7), MSH5(8), NCOR1(22), NR5A1(3), NRIP1(17), PGR(13), PRLR(5), PTGER2(3), SMPD1(4), VDR(8), ZP2(12) 12345156 236 57 228 60 46 90 38 5 49 8 0.146 1.000 1.000 403 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(31), ACAT1(6), ACAT2(4), ACYP1(2), AKR1B1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), DLAT(3), DLD(5), GRHPR(2), LDHA(6), LDHB(3), LDHC(5), LDHD(2), MDH1(2), MDH2(4), ME1(12), ME2(8), ME3(9), PC(12), PCK1(9), PDHA1(7), PDHA2(9), PDHB(3), PKLR(6) 13180165 198 57 195 66 56 73 36 4 28 1 0.475 1.000 1.000 404 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(9), ACADL(8), ACADM(9), ACADSB(6), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), AOC2(7), AOC3(10), CNDP1(4), DPYD(20), DPYS(6), ECHS1(3), EHHADH(10), GAD1(6), GAD2(12), HADHA(5), MLYCD(3), SDS(1), SMS(8), UPB1(10) 10447050 184 56 181 64 48 65 44 3 24 0 0.410 1.000 1.000 405 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(17), BID(2), BIRC2(10), BIRC3(5), CASP10(8), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CFLAR(2), CHUK(8), CYCS(2), DFFB(4), FADD(1), GAS2(7), LMNA(7), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(8), SPTAN1(31), TNFRSF10A(2), TNFRSF10B(5), TNFRSF25(2), TNFSF10(1), TNFSF12(6), TRAF2(3) 11978937 186 56 180 50 49 71 20 2 44 0 0.167 1.000 1.000 406 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(9), ALDH4A1(4), ALDH5A1(7), CAD(25), CPS1(22), EPRS(15), GAD1(6), GAD2(12), GCLC(8), GCLM(2), GFPT1(9), GLS(11), GLS2(7), GLUD1(3), GLUL(7), GMPS(14), GOT1(9), GOT2(3), GPT(2), GPT2(5), GSS(5), NADSYN1(6), PPAT(9), QARS(7) 12092421 207 56 201 63 54 68 43 4 36 2 0.337 1.000 1.000 407 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ACY3(3), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH3B2(7), ALDH7A1(1), ALDH9A1(2), AMDHD1(13), AOC2(7), AOC3(10), ASPA(5), CARM1(5), CNDP1(4), DDC(8), FTCD(7), HAL(6), HARS(5), HARS2(7), HDC(9), HEMK1(2), HNMT(2), LCMT1(2), LCMT2(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(4), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), PRPS1(2), PRPS2(4), UROC1(9), WBSCR22(2) 13908656 218 56 212 77 65 82 39 3 29 0 0.482 1.000 1.000 408 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(9), ACACA(31), ACADL(8), ACADM(9), ACADSB(6), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH6A1(6), ALDH9A1(2), ECHS1(3), EHHADH(10), HADHA(5), LDHA(6), LDHB(3), LDHC(5), MCEE(1), MLYCD(3), MUT(10), PCCA(6), PCCB(8), SDS(1), SUCLA2(5), SUCLG1(5), SUCLG2(10) 12101964 207 56 204 57 46 71 53 4 32 1 0.165 1.000 1.000 409 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(6), BAD(1), BRAF(10), CREB1(5), CREB5(5), DUSP6(2), DUSP9(1), EEF2K(11), EIF4E(1), GRB2(3), MAP2K1(2), MAP2K2(5), MAP3K8(10), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(2), MOS(6), NFKB1(10), RAP1A(4), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), SHC1(6), SOS1(13), SOS2(17), TRAF3(5) 10740371 166 56 162 60 48 59 35 1 21 2 0.669 1.000 1.000 410 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(12), DLG4(10), EPHB2(11), F2(8), F2RL1(4), F2RL2(2), JUN(1), MAP2K5(3), MAPK1(2), MAPK7(14), MAPK8(11), MYEF2(7), PLD1(13), PLD2(10), PLD3(5), PTK2(12), RAF1(9), RASAL1(14), SRC(3), TEC(7), VAV1(12) 10013158 170 56 167 62 56 55 28 3 27 1 0.737 1.000 1.000 411 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(56), ASAH1(6), CAMP(1), CASP3(4), CERK(7), CREB1(5), CREB5(5), CXCL2(2), DAG1(6), EPHB2(11), FOS(3), GNAQ(3), ITPKA(1), ITPKB(11), JUN(1), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(10), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4) 9812900 176 56 172 57 45 67 20 1 40 3 0.318 1.000 1.000 412 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(5), ACAA2(3), ACADL(8), ACADM(9), ACADS(3), ACADSB(6), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH6A1(6), ALDH9A1(2), AOX1(18), BCAT1(7), BCKDHA(5), BCKDHB(4), ECHS1(3), EHHADH(10), HADHA(5), HADHB(4), HIBADH(5), HMGCL(2), IVD(2), MCCC1(8), MCCC2(5), MCEE(1), MUT(10), OXCT1(10), PCCA(6), PCCB(8), SDS(1) 13157737 211 56 208 70 52 79 47 2 31 0 0.476 1.000 1.000 413 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM2(3), CHUK(8), EGR2(6), EGR3(7), GNAQ(3), MAP3K1(30), MYC(8), NFATC1(10), NFATC2(13), NFKB1(10), NFKBIA(3), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RELA(6), SYT1(4), VIP(4), VIPR2(4) 9816248 176 56 171 55 49 65 32 2 26 2 0.264 1.000 1.000 414 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 35 ARSA(3), ARSD(5), ARSE(10), ASAH1(6), B4GALT6(6), CERK(7), DEGS1(5), DEGS2(3), ENPP7(3), GAL3ST1(7), GALC(8), GBA(4), GLA(9), GLB1(6), LCT(32), NEU2(4), NEU3(3), PPAP2A(5), PPAP2B(3), PPAP2C(1), SGMS1(5), SGMS2(5), SGPP1(2), SGPP2(4), SMPD1(4), SMPD2(6), SMPD3(7), SMPD4(8), SPHK1(2), SPHK2(2), SPTLC1(5), SPTLC2(5), UGCG(4), UGT8(14) 12070767 203 55 199 60 51 93 31 3 25 0 0.0806 1.000 1.000 415 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(7), CDK7(7), ERCC3(11), GTF2B(5), GTF2E1(3), GTF2E2(2), GTF2F2(1), GTF2H1(9), GTF2H4(3), ILK(5), POLR1A(15), POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLR3B(14), POLR3D(3), POLR3E(4), POLR3H(4), TAF5(8), TAF6(9), TAF7(4), TAF9(4), TBP(3) 12564504 192 55 191 59 66 62 29 2 32 1 0.346 1.000 1.000 416 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(21), CALM1(2), CALM2(3), CREB1(5), ELK1(3), FOS(3), GNAI1(5), GNAQ(3), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), JUN(1), MAP2K1(2), MAPK3(3), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), RAF1(9), RPS6KA3(19), SYT1(4) 12116635 216 54 208 71 80 62 42 1 30 1 0.264 1.000 1.000 417 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(6), AASDH(10), AASDHPPT(9), AASS(12), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), ATP6V0C(1), BBOX1(1), DLST(8), DOT1L(8), ECHS1(3), EHHADH(10), EHMT1(23), EHMT2(2), GCDH(4), HADHA(5), PLOD1(4), PLOD2(11), PLOD3(6), SDS(1), SHMT1(5), SHMT2(5), TMLHE(6) 12530482 197 54 192 74 65 66 39 5 21 1 0.573 1.000 1.000 418 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(4), AP2A1(7), AP2M1(6), ARF1(3), BAD(1), BTK(12), EEA1(17), GRASP(4), GSK3A(10), GSK3B(13), LYN(9), PDPK1(3), PFKL(8), PFKM(8), PFKP(8), PLCG1(12), PRKCE(10), PRKCZ(2), RAB5A(2), RAC1(1), RPS6KB1(3), VAV2(7) 8954356 150 54 145 55 57 47 24 0 22 0 0.559 1.000 1.000 419 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(4), ALOX15(9), ALOX5(10), CYP1A2(11), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2J2(5), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(5), HSD3B7(5), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), RDH11(1), RDH12(5), RDH13(4), RDH14(2) 8757420 151 53 146 43 47 53 22 4 25 0 0.138 1.000 1.000 420 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), GOT1(9), GOT2(3), GPT(2), GPT2(5), MDH1(2), MDH2(4), ME1(12), ME3(9), PGK1(7), PGK2(6), PKLR(6), RPE(5), RPIA(9), TKT(6), TKTL1(9), TKTL2(16), TPI1(2) 7208802 132 53 128 39 42 56 18 2 14 0 0.110 1.000 1.000 421 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(29), APOA1(3), APOA4(3), APOC1(3), APOC3(1), APOE(1), CETP(5), CYP7A1(11), DGAT1(3), HMGCR(12), LCAT(4), LDLR(7), LIPC(8), LPL(16), LRP1(51), SCARB1(6), SOAT1(9) 9737188 172 53 169 46 66 54 36 0 15 1 0.0275 1.000 1.000 422 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(7), AZIN1(8), CBX3(4), CLOCK(9), CRY1(9), CRY2(3), DNAJA1(3), EIF4G2(7), ETV6(6), GFRA1(9), GSTM3(5), GSTP1(2), HERPUD1(2), HSPA8(8), IDI1(3), KLF9(3), MYF6(8), NCKAP1(8), NCOA4(7), NR1D2(2), PER1(10), PER2(13), PIGF(2), PPP1R3C(4), PPP2CB(4), PSMA4(2), SF3A3(8), SUMO3(3), TOB1(4), TUBB3(6), UGP2(6), VAPA(5), ZFR(10) 13167207 190 52 185 59 59 69 37 2 23 0 0.443 1.000 1.000 423 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(9), ACADM(9), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), AOC2(7), AOC3(10), CNDP1(4), DPYD(20), DPYS(6), ECHS1(3), EHHADH(10), GAD1(6), GAD2(12), HADHA(5), HIBCH(6), MLYCD(3), SMS(8), SRM(1), UPB1(10) 9640368 156 52 153 49 43 58 35 3 17 0 0.205 1.000 1.000 424 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(3), CHIT1(6), CMAS(7), CTBS(4), CYB5R1(3), CYB5R3(4), GFPT1(9), GFPT2(12), GNE(10), GNPDA1(2), GNPDA2(10), GNPNAT1(2), HEXA(3), HEXB(5), HK1(11), HK2(9), HK3(9), LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), NAGK(2), NANS(7), NPL(7), PGM3(3), PHPT1(1), RENBP(4), UAP1(6) 10429868 176 52 174 52 54 57 36 1 28 0 0.258 1.000 1.000 425 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(7), CS(6), DLAT(3), DLD(5), DLST(8), FH(8), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(9), MDH1(2), MDH2(4), OGDH(13), PC(12), PDHA1(7), PDHA2(9), PDHB(3), PDHX(11), PDK1(2), PDK2(4), PDK3(12), PDK4(10), PDP2(4), SDHA(14), SDHB(2), SDHC(2), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(10) 10367375 191 52 189 65 67 68 30 2 24 0 0.408 1.000 1.000 426 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(7), CARS(8), DARS(7), EPRS(15), FARS2(2), GARS(8), HARS(5), IARS(8), KARS(5), LARS(18), LARS2(8), MARS(11), MARS2(4), NARS(10), QARS(7), RARS(13), SARS(4), TARS(9), WARS(6), WARS2(3), YARS(5) 11765558 163 51 160 60 42 65 30 1 25 0 0.901 1.000 1.000 427 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(5), CREB1(5), CREBBP(32), EP300(32), NCOA3(10), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RARA(2), RXRA(3) 7436105 116 51 111 32 30 35 23 3 23 2 0.166 1.000 1.000 428 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(20), GABBR1(11), GPRC5A(7), GPRC5B(6), GPRC5C(3), GPRC5D(4), GRM1(26), GRM2(9), GRM3(18), GRM4(11), GRM5(26), GRM7(19), GRM8(19) 7056881 179 51 171 68 58 64 31 3 20 3 0.371 1.000 1.000 429 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(5), ALDOB(9), ALDOC(3), DERA(8), FBP1(2), FBP2(1), G6PD(6), GPI(7), H6PD(7), PFKL(8), PFKM(8), PFKP(8), PGD(3), PGLS(2), PGM1(6), PGM3(3), PRPS1(2), PRPS1L1(5), PRPS2(4), RBKS(1), RPE(5), RPIA(9), TALDO1(6), TKT(6), TKTL1(9), TKTL2(16) 8567433 149 51 143 48 60 47 19 0 23 0 0.136 1.000 1.000 430 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(5), ACAA2(3), ACAD8(5), ACAD9(8), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1B10(4), AKR1C4(6), AKR1D1(8), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), BAAT(7), CEL(5), CYP27A1(9), CYP7A1(11), HADHB(4), HSD3B7(5), LIPA(8), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SLC27A5(3), SOAT1(9), SOAT2(5), SRD5A1(4) 11346074 177 51 174 66 62 57 31 4 22 1 0.546 1.000 1.000 431 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 25 ALDH1A3(8), ALDH3A1(4), ALDH3B2(7), AOC2(7), AOC3(10), DDC(8), EPX(15), ESCO1(16), ESCO2(8), GOT1(9), GOT2(3), HPD(2), LPO(6), MAOA(12), MAOB(7), MPO(8), NAT6(1), PNPLA3(7), PRDX6(4), SH3GLB1(7), TAT(7), TPO(14) 12074023 170 51 166 56 56 60 31 3 20 0 0.371 1.000 1.000 432 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(16), AP2A1(7), AP2M1(6), BIN1(3), CALM1(2), CALM2(3), DNM1(4), EPN1(8), EPS15(11), NME1(2), NME2(3), PICALM(11), PPP3CA(4), PPP3CB(6), PPP3CC(6), SYNJ1(29), SYNJ2(11), SYT1(4) 8178295 136 51 132 51 45 43 25 0 23 0 0.633 1.000 1.000 433 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(6), CASP2(6), CHUK(8), CRADD(3), IKBKB(13), IKBKG(3), JUN(1), LTA(3), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP4K2(5), MAPK14(4), MAPK8(11), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(8), TANK(4), TNFRSF1A(4), TRAF2(3) 8545840 157 51 155 42 31 59 30 0 36 1 0.196 1.000 1.000 434 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3D(6), CD3E(2), CD3G(3), CD4(6), CREBBP(32), CSK(1), GNAS(24), GNB1(2), GNGT1(1), HLA-DRA(1), LCK(4), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTPRC(17), ZAP70(8) 7957941 155 50 149 51 55 50 24 1 23 2 0.301 1.000 1.000 435 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3D(6), CD3E(2), CD3G(3), CD4(6), CREBBP(32), CSK(1), GNAS(24), GNB1(2), GNGT1(1), HLA-DRA(1), LCK(4), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTPRC(17), ZAP70(8) 7957941 155 50 149 51 55 50 24 1 23 2 0.301 1.000 1.000 436 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(3), ACP2(1), ACP5(5), ACPP(6), ACPT(5), ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), CYP19A1(13), CYP1A1(11), CYP1A2(11), CYP2A13(9), CYP2A6(13), CYP2A7(6), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(5), CYP3A4(10), CYP3A5(6), CYP3A7(5), CYP4B1(4), CYP51A1(4), PON1(12) 10550838 189 50 185 65 57 71 35 1 23 2 0.422 1.000 1.000 437 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(5), CAPN1(5), CAPN2(11), CAPNS1(2), CAPNS2(3), CXCR3(5), EGF(19), EGFR(12), HRAS(1), ITGA1(17), ITGB1(8), MAPK1(2), MAPK3(3), MYL2(2), MYLK(14), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTK2(12), PXN(6), TLN1(23) 12110743 177 50 174 56 64 52 34 1 25 1 0.176 1.000 1.000 438 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM2(3), DLG4(10), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), NOS1(18), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), SYT1(4) 9115431 156 50 153 73 53 50 32 1 19 1 0.941 1.000 1.000 439 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(8), CREBBP(32), EP300(32), FADD(1), HDAC3(12), IKBKB(13), IKBKG(3), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(8), TNFRSF1A(4), TNFRSF1B(2), TRAF6(7) 7984364 141 50 135 36 39 42 29 1 29 1 0.106 1.000 1.000 440 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(5), ACTN1(9), ACTN2(16), CAPN1(5), CAPNS1(2), CAPNS2(3), ITGA1(17), ITGB1(8), ITGB3(11), PTK2(12), PXN(6), RAC1(1), SPTAN1(31), SRC(3), TLN1(23) 10471567 152 50 149 56 60 44 21 1 26 0 0.621 1.000 1.000 441 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(17), ACO2(7), CS(6), DLD(5), DLST(8), FH(8), IDH1(4), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(9), MDH1(2), MDH2(4), PC(12), PCK1(9), SDHA(14), SDHB(2), SUCLA2(5), SUCLG1(5), SUCLG2(10) 7507343 138 49 137 53 58 43 21 2 14 0 0.564 1.000 1.000 442 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(3), ALAS1(8), ALAS2(10), BLVRA(1), BLVRB(1), COX10(3), COX15(3), CP(13), CPOX(6), EARS2(5), EPRS(15), FECH(7), FTH1(2), FTMT(7), GUSB(5), HCCS(1), HMBS(8), HMOX1(4), HMOX2(3), MMAB(2), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2A1(9), UGT2A3(5), UGT2B10(18), UGT2B11(8), UGT2B15(9), UGT2B17(7), UGT2B28(15), UGT2B4(11), UGT2B7(5), UROD(3), UROS(3) 15055211 245 49 233 67 66 105 43 2 29 0 0.127 1.000 1.000 443 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(14), ACE2(22), AGT(8), AGTR1(4), AGTR2(11), ANPEP(15), CMA1(2), CPA3(5), CTSA(9), CTSG(3), ENPEP(19), LNPEP(10), MAS1(3), MME(11), NLN(3), REN(4), THOP1(3) 7592031 146 49 142 51 33 60 32 2 18 1 0.540 1.000 1.000 444 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(8), BAIAP2(5), CASP1(8), CASP3(4), CASP7(1), CASP8(21), GAPDH(2), INS(1), INSR(18), ITCH(10), MAGI1(22), MAGI2(28), RERE(19), WWP1(19), WWP2(9) 8511067 175 49 169 52 53 58 33 1 28 2 0.309 1.000 1.000 445 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(7), ABAT(9), ACADS(3), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH5A1(7), ALDH9A1(2), ECHS1(3), EHHADH(10), GAD1(6), GAD2(12), HADHA(5), HMGCL(2), L2HGDH(5), OXCT1(10), PDHA1(7), PDHA2(9), PDHB(3), SDHB(2), SDS(1) 9314002 158 48 154 49 45 54 32 3 24 0 0.205 1.000 1.000 446 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(5), GALNS(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), HGSNAT(10), HPSE(6), HPSE2(11), HYAL1(2), HYAL2(4), IDS(8), IDUA(5), LCT(32), NAGLU(3), SPAM1(15) 7347340 129 48 129 52 28 57 26 2 16 0 0.871 1.000 1.000 447 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), AGPS(8), CHPT1(1), ENPP2(22), ENPP6(11), PAFAH1B1(3), PAFAH1B2(3), PAFAH2(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLD1(13), PLD2(10), PPAP2A(5), PPAP2B(3), PPAP2C(1) 8426272 144 48 139 43 45 51 19 3 25 1 0.245 1.000 1.000 448 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(5), BIRC2(10), BIRC3(5), CASP3(4), CASP8(21), CFLAR(2), FADD(1), IKBKG(3), JUN(1), MAP2K4(9), MAP3K3(8), MAP3K7(9), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), NR2C2(7), RALBP1(6), RIPK1(8), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3) 9349804 141 48 138 39 35 55 23 0 26 2 0.212 1.000 1.000 449 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(6), AKR1D1(8), ARSB(5), ARSD(5), ARSE(10), CYP11B1(8), CYP11B2(8), HSD11B1(6), HSD17B2(2), HSD17B3(7), HSD17B8(2), HSD3B1(3), HSD3B2(6), SRD5A1(4), STS(8), SULT1E1(9), SULT2A1(7), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2B15(9), UGT2B4(11) 9754557 169 47 163 57 45 79 25 2 18 0 0.411 1.000 1.000 450 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 22 ARSA(3), ARSB(5), ARSD(5), ARSE(10), ASAH1(6), GAL3ST1(7), GALC(8), GBA(4), GLA(9), GLB1(6), LCT(32), NEU2(4), NEU3(3), PPAP2A(5), PPAP2B(3), PPAP2C(1), SMPD1(4), SMPD2(6), SPTLC1(5), SPTLC2(5), UGCG(4) 8264638 135 47 133 43 33 65 23 1 13 0 0.312 1.000 1.000 451 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(3), ALDH18A1(9), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), AMD1(3), AOC2(7), AOC3(10), ARG1(5), ARG2(3), ASL(2), ASS1(1), CPS1(22), GATM(5), MAOA(12), MAOB(7), NAGS(3), ODC1(2), OTC(7), SAT1(5), SAT2(1), SMS(8), SRM(1) 10557702 146 47 143 60 46 52 26 3 17 2 0.848 1.000 1.000 452 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(6), CARM1(5), CBS(11), CTH(6), GGT1(5), HEMK1(2), LCMT1(2), LCMT2(9), MARS(11), MARS2(4), MAT1A(4), MAT2B(10), METTL2B(4), METTL6(4), PAPSS1(8), PAPSS2(7), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SCLY(3), SEPHS1(12), SEPHS2(5), WBSCR22(2) 8840900 156 47 152 53 55 58 16 2 25 0 0.322 1.000 1.000 453 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), FPGT(6), GCK(2), GMDS(4), GMPPA(4), GMPPB(2), HK1(11), HK2(9), HK3(9), KHK(2), MPI(5), PFKFB1(8), PFKFB3(4), PFKFB4(4), PFKM(8), PFKP(8), PMM2(6), SORD(5), TPI1(2) 8759023 120 46 118 60 46 33 22 0 19 0 0.969 1.000 1.000 454 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(5), ACAA2(3), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1C4(6), AKR1D1(8), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), BAAT(7), CEL(5), CYP27A1(9), CYP7A1(11), HADHB(4), SOAT2(5), SRD5A1(4) 8301184 143 45 140 51 49 45 28 3 18 0 0.436 1.000 1.000 455 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), GOT1(9), GOT2(3), GPT(2), GPT2(5), MDH1(2), MDH2(4), ME1(12), ME2(8), ME3(9), PGK1(7), PKLR(6), RPE(5), RPIA(9), TKT(6), TPI1(2) 6427743 109 45 107 32 32 45 19 2 11 0 0.160 1.000 1.000 456 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(9), AGT(8), AGTR2(11), EDN1(4), EDNRA(5), EDNRB(4), EGF(19), EGFR(12), FOS(3), HRAS(1), JUN(1), MYC(8), NFKB1(10), PLCG1(12), PRKCA(11), RELA(6) 7459154 124 45 120 46 30 47 31 2 14 0 0.706 1.000 1.000 457 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(4), POLD1(10), POLD2(6), POLE(47), POLG(6), POLL(6), POLQ(29) 6044414 108 45 95 31 31 56 14 1 6 0 0.249 1.000 1.000 458 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(15), G6PD(6), GCLC(8), GCLM(2), GGT1(5), GPX2(1), GPX5(6), GPX6(7), GPX7(1), GSR(6), GSS(5), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTA5(4), GSTK1(5), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), IDH1(4), IDH2(5), MGST1(4), MGST3(2), TXNDC12(5) 7340923 129 45 125 41 39 44 30 1 14 1 0.294 1.000 1.000 459 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(7), FUCA1(3), FUCA2(4), GLB1(6), HEXA(3), HEXB(5), LCT(32), MAN2B1(14), MAN2B2(5), MAN2C1(7), MANBA(12), NEU2(4), NEU3(3) 6888206 105 45 104 41 29 40 22 3 11 0 0.778 1.000 1.000 460 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(15), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(2), POLR3H(4) 8487029 124 45 123 37 43 42 17 2 19 1 0.284 1.000 1.000 461 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(8), CHUK(8), IFNG(10), IKBKB(13), IL2(2), IL4(1), JUN(1), MAP3K1(30), MAP3K5(25), MAP4K5(7), MAPK14(4), MAPK8(11), NFKB1(10), NFKBIA(3), RELA(6), TNFRSF9(2), TNFSF9(6), TRAF2(3) 7209024 150 44 146 40 39 62 19 1 28 1 0.222 1.000 1.000 462 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(4), CFL1(1), GNAQ(3), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), LIMK1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(2), NOX1(16), PIK3C2G(16), PLCB1(5), PPP1R12B(19), PRKCA(11), PTK2(12), RAF1(9), ROCK2(17) 9254834 158 44 153 46 49 47 32 3 27 0 0.391 1.000 1.000 463 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(5), CALCR(9), CALCRL(8), CD97(13), CRHR1(3), CRHR2(2), ELTD1(12), EMR1(17), EMR2(4), GHRHR(2), GIPR(5), GLP1R(5), GLP2R(11), GPR64(11), LPHN1(17), LPHN2(22), LPHN3(21), SCTR(5), VIPR1(3), VIPR2(4) 10055000 179 44 174 70 53 71 27 1 25 2 0.607 1.000 1.000 464 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(6), AMD1(3), BHMT(2), CBS(11), CTH(6), DNMT1(14), DNMT3A(8), DNMT3B(15), MARS(11), MARS2(4), MAT1A(4), MAT2B(10), MTAP(4), MTR(11), SRM(1), TAT(7) 7468924 117 44 114 51 46 37 19 1 14 0 0.861 1.000 1.000 465 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), CYP2C19(6), CYP2C9(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ECHS1(3), EHHADH(10), ESCO1(16), ESCO2(8), HADHA(5), NAT6(1), PNPLA3(7), SH3GLB1(7), YOD1(2) 11203507 118 44 117 43 37 47 19 2 13 0 0.683 1.000 1.000 466 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(9), CA1(6), CA12(1), CA13(4), CA14(4), CA2(2), CA3(5), CA4(1), CA5A(6), CA5B(7), CA6(2), CA7(5), CA8(6), CA9(4), CPS1(22), CTH(6), GLS(11), GLS2(7), GLUD1(3), GLUD2(9), GLUL(7), HAL(6) 7721466 135 44 130 46 39 52 17 2 23 2 0.554 1.000 1.000 467 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(8), FADD(1), IKBKB(13), IKBKG(3), IL1R1(5), IRAK1(4), MAP3K1(30), MAP3K7(9), MYD88(2), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(8), TLR4(17), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF6(7) 8589976 135 44 134 32 29 53 24 0 27 2 0.109 1.000 1.000 468 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(5), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR7(6), CD28(3), CD4(6), CSF2(1), CXCR3(5), CXCR4(1), IFNG(10), IFNGR1(4), IFNGR2(4), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18R1(9), IL2(2), IL4(1), IL4R(6), IL5(2), TGFB1(1), TGFB2(5), TGFB3(9) 7439499 134 44 133 42 37 52 23 1 21 0 0.249 1.000 1.000 469 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 ALDH1A3(8), ALDH3A1(4), ALDH3B2(7), AOC2(7), AOC3(10), DDC(8), EPX(15), GOT1(9), GOT2(3), HPD(2), LPO(6), MAOA(12), MAOB(7), MPO(8), PRDX2(2), PRDX5(1), PRDX6(4), TAT(7), TPO(14) 7660602 134 44 130 48 46 45 25 3 15 0 0.435 1.000 1.000 470 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(21), ADRB2(7), GNAS(24), PLCE1(39), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3) 5147041 118 44 114 34 44 28 27 1 17 1 0.186 1.000 1.000 471 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(12), DYRK1B(4), GLI2(10), GLI3(28), GSK3B(13), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), SHH(4), SMO(9), SUFU(3) 5610085 110 44 107 55 40 38 12 3 15 2 0.903 1.000 1.000 472 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(17), BIRC2(10), BIRC3(5), CASP10(8), CASP3(4), CASP7(1), CASP8(21), CASP9(3), DFFB(4), GZMB(4), PRF1(8), SCAP(11), SREBF1(2), SREBF2(13) 6378058 111 43 106 38 30 43 15 0 23 0 0.596 1.000 1.000 473 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(7), CYB5R3(4), GCK(2), GFPT1(9), GNE(10), GNPDA1(2), GNPDA2(10), HEXA(3), HEXB(5), HK1(11), HK2(9), HK3(9), PGM3(3), RENBP(4), UAP1(6) 6187133 94 42 93 34 32 24 21 1 16 0 0.702 1.000 1.000 474 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(5), EPHA4(19), EPHB1(26), FYN(5), ITGA1(17), ITGB1(8), L1CAM(20), LYN(9), RAP1B(2), SELP(13) 5796064 124 42 121 38 38 46 21 1 18 0 0.206 1.000 1.000 475 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(3), B4GALNT1(6), GLB1(6), HEXA(3), HEXB(5), LCT(32), SLC33A1(9), ST3GAL1(2), ST3GAL2(6), ST3GAL5(4), ST6GALNAC3(8), ST6GALNAC4(4), ST6GALNAC5(2), ST6GALNAC6(6), ST8SIA1(2), ST8SIA5(8) 5831166 106 42 104 40 30 42 18 2 14 0 0.654 1.000 1.000 476 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPS7(3), RPL10A(1), RPL10L(8), RPL11(3), RPL13(1), RPL13A(1), RPL14(2), RPL18(1), RPL18A(2), RPL19(4), RPL21(3), RPL22L1(4), RPL23A(4), RPL24(2), RPL27(1), RPL27A(3), RPL28(2), RPL29(2), RPL3(2), RPL34(1), RPL35A(2), RPL36AL(1), RPL37(2), RPL37A(1), RPL38(1), RPL39(4), RPL3L(3), RPL6(3), RPL7(1), RPL8(2), RPL9(2), RPS10(1), RPS11(1), RPS12(2), RPS13(1), RPS15A(1), RPS16(1), RPS18(3), RPS2(1), RPS20(3), RPS21(1), RPS24(2), RPS25(2), RPS27(1), RPS28(1), RPS29(2), RPS3(3), RPS3A(1), RPS6(7), RPS7(5), RPS8(2), RPSA(1) 8167792 114 42 111 38 34 46 24 2 8 0 0.764 1.000 1.000 477 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(19), CALM1(2), CALM2(3), CAPN2(11), CAPNS1(2), CAPNS2(3), EP300(32), HDAC1(5), HDAC2(3), MEF2D(7), NFATC1(10), NFATC2(13), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKCA(11), SYT1(4) 8576701 141 42 136 40 51 31 31 1 27 0 0.160 1.000 1.000 478 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(5), ADCY1(21), CAP1(4), CCNB1(8), CDC25C(5), GNAI1(5), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), MAPK1(2), MAPK3(3), MYT1(18), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RPS6KA1(1), SRC(3) 7150582 130 42 126 40 50 39 23 1 16 1 0.171 1.000 1.000 479 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), G6PD(6), GPI(7), H6PD(7), PFKM(8), PFKP(8), PGD(3), PGLS(2), PGM1(6), PGM3(3), PRPS1(2), PRPS1L1(5), PRPS2(4), RBKS(1), RPE(5), RPIA(9), TAL1(1), TALDO1(6), TKT(6) 7121683 109 42 106 40 40 36 17 0 16 0 0.437 1.000 1.000 480 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(8), DUSP1(2), IKBKAP(13), IKBKB(13), IKBKG(3), LTA(3), MAP3K1(30), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(8), TANK(4), TNFAIP3(3), TNFRSF1B(2), TRAF1(5), TRAF2(3), TRAF3(5) 8209617 121 42 120 32 28 50 16 0 26 1 0.171 1.000 1.000 481 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(12), CSF1R(8), EGF(19), EGFR(12), GRB2(3), MET(17), PDGFRA(24), PRKCA(11), SH3GLB1(7), SH3GLB2(6), SH3KBP1(7), SRC(3) 7155198 129 41 126 42 33 44 32 0 18 2 0.358 1.000 1.000 482 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(12), F2(8), F2R(6), F3(5), F5(47), F7(2), FGA(26), FGB(7), FGG(9), PROC(4), PROS1(21), SERPINC1(10), TFPI(8) 5927459 165 41 157 42 34 83 31 1 14 2 0.139 1.000 1.000 483 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(12), EXT2(6), EXTL1(9), EXTL2(8), EXTL3(10), GLCE(5), HS2ST1(7), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), HS3ST5(9), HS6ST1(2), HS6ST2(9), HS6ST3(3), NDST1(14), NDST2(9), NDST3(14), NDST4(15) 7439901 149 41 147 48 40 58 32 1 17 1 0.370 1.000 1.000 484 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(4), GRB2(3), IL2RG(11), IL4(1), IL4R(6), IRS1(13), JAK1(20), JAK3(10), RPS6KB1(3), SHC1(6), STAT6(10) 5172677 87 41 87 29 25 31 16 1 14 0 0.478 1.000 1.000 485 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(6), BHMT(2), CBS(11), CTH(6), DNMT1(14), DNMT3A(8), DNMT3B(15), MARS(11), MARS2(4), MAT1A(4), MAT2B(10), MTR(11) 6295427 102 41 99 42 41 31 15 1 14 0 0.750 1.000 1.000 486 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(21), ARHGEF1(12), GNA12(7), GNA13(7), GNAQ(3), GNB1(2), GNGT1(1), MYL2(2), MYLK(14), PLCB1(5), PPP1R12B(19), PRKCA(11), ROCK1(22) 7598901 126 41 122 47 43 40 26 2 11 4 0.777 1.000 1.000 487 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(9), CA1(6), CA12(1), CA14(4), CA2(2), CA3(5), CA4(1), CA5A(6), CA5B(7), CA6(2), CA7(5), CA8(6), CA9(4), CPS1(22), CTH(6), GLS(11), GLS2(7), GLUD1(3), GLUL(7), HAL(6) 6927980 122 41 117 36 33 48 16 2 21 2 0.304 1.000 1.000 488 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(11), GTF2A1(3), GTF2B(5), GTF2E1(3), GTF2F1(7), HDAC3(12), NCOA1(19), NCOA2(15), NCOA3(10), NCOR2(24), POLR2A(21), RARA(2), RXRA(3), TBP(3) 8960600 138 41 135 45 53 40 26 1 18 0 0.378 1.000 1.000 489 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(17), ARHGDIB(3), BIRC2(10), BIRC3(5), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CYCS(2), DFFB(4), GZMB(4), LMNA(7), LMNB1(5), LMNB2(4), PRF1(8) 6936180 132 40 126 40 35 49 20 1 27 0 0.509 1.000 1.000 490 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(4), C1QB(3), C1R(11), C1S(8), C2(2), C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19), MASP1(13), MASP2(7), MBL2(4) 7752035 156 40 149 50 34 74 30 0 16 2 0.420 1.000 1.000 491 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(15), CD2(4), CD33(6), CD5(10), CD7(3), CSF2(1), IFNA1(2), IFNB1(3), IFNG(10), IL10(4), IL12A(5), IL12B(2), IL3(2), IL4(1), IL5(2), ITGAX(14), TLR2(16), TLR4(17), TLR7(17), TLR9(6) 6754142 140 40 138 43 41 58 19 1 19 2 0.119 1.000 1.000 492 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(17), ACO2(7), AFMID(6), CS(6), GRHPR(2), HAO1(3), HAO2(10), HYI(2), MDH1(2), MDH2(4), MTHFD1(7), MTHFD1L(15), MTHFD2(4) 4944780 85 40 84 29 35 23 18 0 9 0 0.344 1.000 1.000 493 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(7), FUCA1(3), FUCA2(4), GLB1(6), HEXA(3), HEXB(5), LCT(32), MAN2C1(7), MANBA(12), NEU2(4), NEU3(3) 5549271 86 40 85 32 19 32 22 2 11 0 0.788 1.000 1.000 494 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(3), BLVRA(1), BLVRB(1), CP(13), CPOX(6), EPRS(15), FECH(7), GUSB(5), HCCS(1), HMBS(8), HMOX1(4), HMOX2(3), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2B15(9), UGT2B4(11), UROD(3), UROS(3) 10003330 138 40 133 44 42 61 20 1 14 0 0.470 1.000 1.000 495 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 CNR1(11), CNR2(6), DNMT1(14), MTNR1A(5), MTNR1B(4), PTAFR(4), PTGDR(9), PTGER2(3), PTGER4(12), PTGFR(10), PTGIR(3) 3658357 81 40 79 29 31 30 16 0 4 0 0.277 1.000 1.000 496 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(4), C1QB(3), C1R(11), C1S(8), C2(2), C3(22), C5(18), C6(16), C7(20), C8A(9), C8B(5), C9(19), MASP1(13) 7552563 150 39 142 47 33 67 31 0 17 2 0.386 1.000 1.000 497 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(15), G6PD(6), GCLC(8), GCLM(2), GGT1(5), GPX2(1), GPX5(6), GSS(5), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), IDH1(4), IDH2(5), MGST1(4), MGST3(2), PGD(3) 6581275 104 39 101 33 29 39 25 1 9 1 0.333 1.000 1.000 498 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(31), ACACB(29), FASN(9), MCAT(3), OLAH(4), OXSM(6) 5404313 82 39 79 35 31 22 15 2 9 3 0.770 1.000 1.000 499 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 21 AOX1(18), BST1(1), CD38(6), ENPP1(12), ENPP3(17), NADK(7), NADSYN1(6), NMNAT1(3), NMNAT2(3), NMNAT3(1), NNMT(6), NNT(7), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5E(6), NT5M(2), NUDT12(4), QPRT(2) 7699061 118 39 116 38 37 42 33 0 6 0 0.339 1.000 1.000 500 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG5(3), ATG7(5), BECN1(1), GABARAP(1), GABARAPL1(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNG(10), INS(1), PIK3C3(14), PIK3R4(21), PRKAA1(8), PRKAA2(11), ULK1(5), ULK2(11), ULK3(5) 7623927 137 39 136 38 29 64 24 0 19 1 0.366 1.000 1.000 501 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(14), ABCC2(30), ABCG2(16), BCHE(17), CES1(13), CES2(2), CYP3A4(10), CYP3A5(6), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3) 8435358 153 39 149 44 35 65 40 0 11 2 0.152 1.000 1.000 502 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(8), F2R(6), GNAI1(5), GNB1(2), GNGT1(1), HRAS(1), ITGA1(17), ITGB1(8), MAP2K1(2), MAPK1(2), MAPK3(3), PLA2G4A(13), PLCB1(5), PRKCA(11), PTGS1(5), PTK2(12), RAF1(9), SRC(3), SYK(4), TBXAS1(7) 8821295 124 39 123 45 29 44 27 4 20 0 0.695 1.000 1.000 503 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM2(3), CCL4(5), CCR5(6), CXCL12(3), CXCR4(1), FOS(3), GNAQ(3), JUN(1), MAPK14(4), MAPK8(11), PLCG1(12), PRKCA(11), PTK2B(15), SYT1(4) 4962945 84 38 82 32 25 29 18 0 12 0 0.681 1.000 1.000 504 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(21), GNAS(24), GNB1(2), GNGT1(1), PPP2CA(6), PRKAA1(8), PRKAA2(11), PRKAB1(6), PRKAB2(1), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAG2(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3) 5373906 114 38 110 35 47 32 16 2 16 1 0.276 1.000 1.000 505 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(19), EGFR(12), MAP2K1(2), MAP3K1(30), MAPK14(4), NCOR2(24), RARA(2), RXRA(3), THRA(4), THRB(4) 6019780 104 38 102 36 29 32 21 1 20 1 0.610 1.000 1.000 506 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(4), GABARAP(1), GABRA1(14), GABRA2(13), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(8), GPHN(17), NSF(3), SRC(3), UBQLN1(6) 4390786 112 38 106 31 31 47 20 0 14 0 0.193 1.000 1.000 507 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(5), GALNS(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), IDS(8), IDUA(5), LCT(32), NAGLU(3) 5119464 81 38 81 34 19 33 18 2 9 0 0.832 1.000 1.000 508 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 23 ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), AOC2(7), AOC3(10), ASPA(5), CNDP1(4), DDC(8), HAL(6), HARS(5), HDC(9), HNMT(2), MAOA(12), MAOB(7), PRPS1(2), PRPS2(4) 8613975 135 38 130 45 42 46 27 2 18 0 0.361 1.000 1.000 509 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BET1(2), BNIP1(4), GOSR1(3), GOSR2(1), SNAP23(3), SNAP25(7), SNAP29(4), STX10(1), STX11(6), STX12(3), STX16(1), STX17(1), STX18(2), STX19(3), STX2(6), STX3(7), STX4(6), STX5(5), STX6(3), STX7(6), STX8(3), TSNARE1(3), USE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP5(1), VAMP7(3), VTI1A(1), VTI1B(6), YKT6(4) 5962055 102 38 98 30 33 29 19 0 21 0 0.363 1.000 1.000 510 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM2(3), CAMK1(3), CAMK1G(5), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CAMK4(5), ESRRA(2), HDAC5(12), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), PPARA(2), PPP3CA(4), PPP3CB(6), PPP3CC(6), SLC2A4(9), SYT1(4), YWHAH(3) 7515013 110 38 109 37 41 33 19 0 17 0 0.345 1.000 1.000 511 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLRMT(11) 4571137 85 38 84 25 32 26 13 0 13 1 0.307 1.000 1.000 512 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM1(2), CALM2(3), CDKN1A(1), GNAQ(3), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKCA(11), SP1(7), SP3(10), SYT1(4) 7204844 108 37 104 42 38 32 23 0 15 0 0.735 1.000 1.000 513 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(3), CSNK1D(3), DRD1(6), DRD2(8), GRM1(26), PLCB1(5), PPP1CA(2), PPP1R1B(2), PPP2CA(6), PPP3CA(4), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3) 5735718 94 37 93 41 30 35 12 4 12 1 0.762 1.000 1.000 514 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(6), AOC2(7), AOC3(10), CES1(13), DDHD1(9), ESCO1(16), ESCO2(8), LIPA(8), NAT6(1), PLA1A(6), PNPLA3(7), PPME1(3), PRDX6(4), SH3GLB1(7) 9195734 105 37 102 31 27 42 21 0 14 1 0.348 1.000 1.000 515 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22RA1(4), IL22RA2(1), JAK1(20), JAK2(17), JAK3(10), STAT1(15), STAT3(11), STAT5A(5), STAT5B(7), TYK2(10) 6607070 104 37 103 41 29 38 18 0 16 3 0.752 1.000 1.000 516 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 10 CD44(5), ICAM1(2), ITGA4(10), ITGAL(17), ITGAM(21), ITGB1(8), ITGB2(15), SELE(5), SELL(5), SELP(13) 5968706 101 37 97 34 25 40 14 0 21 1 0.419 1.000 1.000 517 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(9), ARG1(5), ARG2(3), ASL(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(22), GAMT(3), GATM(5), GLUD1(3), NAGS(3), OAT(7), ODC1(2), OTC(7), PYCR1(3), SMS(8) 6217565 93 37 92 38 28 32 17 2 12 2 0.882 1.000 1.000 518 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(4), C1QB(3), C1R(11), C1S(8), C2(2), C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19) 6333689 132 36 126 43 25 60 29 0 16 2 0.539 1.000 1.000 519 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(17), ACO2(7), CS(6), GRHPR(2), HAO1(3), HAO2(10), HYI(2), MDH1(2), MDH2(4), MTHFD1(7), MTHFD1L(15), MTHFD2(4) 4710422 79 36 78 27 32 21 18 0 8 0 0.384 1.000 1.000 520 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(8), CARS2(5), CDO1(4), CTH(6), GOT1(9), GOT2(3), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(5), MPST(1), SDS(1), SULT1B1(7), SULT1C2(4), SULT1C4(4), SULT4A1(4) 4529700 80 36 77 30 17 30 18 2 13 0 0.811 1.000 1.000 521 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ATP6V0C(1), CAT(4), EPX(15), LPO(6), MPO(8), PRDX2(2), PRDX5(1), PRDX6(4), SHMT1(5), SHMT2(5), TPO(14) 4251973 65 36 63 29 27 22 8 1 7 0 0.824 1.000 1.000 522 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(11), ESR2(5), ITPKA(1), PDE1A(14), PDE1B(7), PLCB1(5), PLCB2(8), PRL(9), TRH(1), VIP(4) 3949492 65 36 62 24 17 19 15 3 11 0 0.789 1.000 1.000 523 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(5), ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(4), NCKAP1(8), NTRK1(13), PIR(6), PSMA7(2), RAC1(1), WASF1(3), WASF2(3), WASF3(8), WASL(8) 5632560 82 35 82 27 25 36 10 0 11 0 0.503 1.000 1.000 524 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 GATA3(3), IL4(1), IL5(2), MAF(2), MAP2K3(7), MAPK14(4), NFATC1(10), NFATC2(13), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3) 3863826 69 35 67 30 27 18 13 1 9 1 0.602 1.000 1.000 525 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(4), EPX(15), LPO(6), MPO(8), MTHFR(9), PRDX6(4), SHMT1(5), SHMT2(5), TPO(14) 4173957 70 35 67 28 30 21 8 2 9 0 0.699 1.000 1.000 526 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(10), AMT(2), ATIC(7), ATP6V0C(1), DHFR(4), GART(9), MTHFD1(7), MTHFD1L(15), MTHFD2(4), MTHFR(9), MTR(11), SHMT1(5), SHMT2(5) 6599249 89 35 86 30 35 30 13 1 10 0 0.286 1.000 1.000 527 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(3), CD3D(6), CD3E(2), CD3G(3), IFNG(10), IL2(2), IL2RA(4), IL4(1), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6), TGFBR3(15), TOB1(4), TOB2(5) 3917492 82 35 82 29 25 35 10 1 11 0 0.629 1.000 1.000 528 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(3), ACP2(1), ACP5(5), ACP6(4), ACPP(6), ACPT(5), ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), CMBL(3), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), PON1(12), PON2(6), PON3(5) 6438004 106 34 104 30 24 39 26 1 16 0 0.148 1.000 1.000 529 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(4), B3GAT2(1), B3GAT3(2), B4GALT7(4), CHPF(5), CHST11(8), CHST12(3), CHST14(3), CHST3(4), CHST7(4), CHSY1(8), DSE(22), UST(3), XYLT1(16), XYLT2(4) 4484184 91 34 90 35 36 30 21 0 4 0 0.603 1.000 1.000 530 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(10), AMT(2), ATIC(7), DHFR(4), FTCD(7), GART(9), MTHFD1(7), MTHFD1L(15), MTHFD2(4), MTHFR(9), MTR(11), SHMT1(5), SHMT2(5) 6928161 95 34 92 33 36 32 16 1 10 0 0.371 1.000 1.000 531 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(32), ABCB11(15), ABCB4(28), ABCC1(14), ABCC3(10), GSTP1(2) 5405704 101 34 98 38 19 41 24 0 13 4 0.681 1.000 1.000 532 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(2), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT5(2), DDOST(3), DPAGT1(3), DPM1(2), FUT8(10), MAN1A1(13), MAN1B1(5), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), RPN1(3), RPN2(5), ST6GAL1(7) 6843201 106 34 100 37 37 32 27 1 9 0 0.618 1.000 1.000 533 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(15), CKM(3), EIF4E(1), FBL(3), GPT(2), LDHA(6), LDHB(3), LDHC(5), MAPK14(4), NCL(7) 3281547 49 34 49 22 9 18 11 3 7 1 0.930 1.000 1.000 534 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(4), CHAT(5), COMT(3), DBH(9), DDC(8), GAD1(6), GAD2(12), HDC(9), MAOA(12), PAH(2), PNMT(2), SLC18A3(6), TH(3), TPH1(9) 4928980 92 33 90 33 28 27 19 1 15 2 0.430 1.000 1.000 535 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(11), ACO1(17), ACO2(7), ACSS1(5), ACSS2(5), FH(8), IDH1(4), IDH2(5), MDH1(2), MDH2(4), SUCLA2(5) 4873171 73 33 73 34 28 24 14 0 7 0 0.863 1.000 1.000 536 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), BLVRB(1), HMOX1(4), IL10(4), IL10RA(4), IL10RB(6), IL6(5), JAK1(20), STAT1(15), STAT3(11), STAT5A(5) 4358319 76 33 75 28 25 20 13 0 18 0 0.580 1.000 1.000 537 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(8), ADSS(6), DHFR(4), HPRT1(2), IMPDH1(6), MTHFD2(4), NME2(3), OAZ1(1), POLB(4), POLD1(10), POLG(6), PRPS2(4), RRM1(2), SRM(1) 4466818 61 33 60 28 21 17 12 0 11 0 0.926 1.000 1.000 538 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(6), CBS(11), CTH(6), GGT1(5), MARS(11), MARS2(4), MAT1A(4), MAT2B(10), PAPSS1(8), PAPSS2(7), SCLY(3), SEPHS1(12) 4419353 87 33 84 30 38 27 9 1 12 0 0.362 1.000 1.000 539 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(15), LPO(6), MPO(8), PRDX2(2), PRDX5(1), PRDX6(4), TPO(14), TYR(12) 3491995 62 33 60 26 21 21 13 1 6 0 0.804 1.000 1.000 540 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(15), GBA(4), LPO(6), MPO(8), PRDX6(4), TPO(14) 3039937 51 32 49 23 19 18 8 1 5 0 0.842 1.000 1.000 541 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 7 CD44(5), ICAM1(2), ITGAL(17), ITGAM(21), ITGB2(15), SELE(5), SELL(5) 3941677 70 32 69 31 19 26 9 0 15 1 0.813 1.000 1.000 542 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(24), GNB1(2), GNGT1(1), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11) 3374899 69 31 66 24 31 17 10 1 9 1 0.555 1.000 1.000 543 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(29), GNA12(7), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAR2A(4), PRKAR2B(3) 3655022 58 31 56 20 15 20 13 0 9 1 0.677 1.000 1.000 544 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), CHST1(8), CHST2(2), CHST4(4), CHST6(6), FUT8(10), ST3GAL1(2), ST3GAL2(6), ST3GAL3(6), ST3GAL4(3) 4140897 78 31 76 42 38 21 13 1 5 0 0.970 1.000 1.000 545 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(5), ACOX1(7), ACOX3(8), ELOVL2(8), ELOVL5(2), ELOVL6(4), FADS1(4), FADS2(2), FASN(9), HADHA(5), HSD17B12(4), PECR(6), SCD(6) 4854200 70 31 70 28 26 21 12 0 11 0 0.568 1.000 1.000 546 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(4), PSMB7(2), PSMC2(3), PSMC3(1), PSMD1(12), PSMD11(6), PSMD12(5), PSMD13(1), PSMD2(11), PSMD6(2) 5921391 77 31 73 24 21 25 12 0 19 0 0.545 1.000 1.000 547 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(20), JAK2(17), JAK3(10), MAPK1(2), MAPK3(3), STAT3(11), TYK2(10) 4165944 73 31 73 26 16 25 15 0 14 3 0.654 1.000 1.000 548 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(4), DHCR7(2), FDFT1(1), FDPS(8), HMGCR(12), HMGCS1(6), IDI1(3), LSS(6), MVD(3), MVK(3), NSDHL(10), PMVK(3), SQLE(5) 4725661 66 30 65 30 18 24 17 0 7 0 0.922 1.000 1.000 549 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(11), ERBB4(27), NRG2(4), NRG3(15), PRKCA(11), PSEN1(5) 3322589 73 30 72 26 23 25 14 0 10 1 0.664 1.000 1.000 550 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(8), CYP51A1(4), DHCR24(6), DHCR7(2), EBP(2), FDFT1(1), FDPS(8), GGCX(9), GGPS1(2), HMGCR(12), HSD17B7(5), IDI1(3), IDI2(1), LSS(6), MVD(3), MVK(3), NQO1(3), NSDHL(10), PMVK(3), SQLE(5), TM7SF2(2), VKORC1(1) 6930322 99 30 98 51 28 43 18 0 10 0 0.994 1.000 1.000 551 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(5), CHPT1(1), HEMK1(2), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(4), PCYT1A(3), PCYT1B(4), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), WBSCR22(2) 5002863 72 30 71 28 18 30 7 2 15 0 0.748 1.000 1.000 552 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), ECHS1(3), EHHADH(10), HADHA(5), SDS(1) 4375145 66 30 65 31 19 25 15 2 5 0 0.870 1.000 1.000 553 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGA4(10), ITGAL(17), ITGB1(8), ITGB2(15), SELE(5), SELL(5) 4471919 67 30 65 28 19 24 12 0 12 0 0.769 1.000 1.000 554 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(4), PSMB7(2), PSMC3(1), PSMD14(2), RPN1(3), RPN2(5), UBE2A(3), UBE3A(16) 4871346 66 30 64 24 21 15 14 1 15 0 0.750 1.000 1.000 555 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(17), ACO2(7), FH(8), IDH1(4), IDH2(5), MDH1(2), MDH2(4), SDHB(2), SUCLA2(5) 3292258 54 30 54 26 23 15 11 0 5 0 0.879 1.000 1.000 556 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(6), GNAQ(3), GNB1(2), GNGT1(1), HTR2C(16), PLCB1(5), TUB(13) 2575796 46 30 44 19 15 12 10 4 5 0 0.782 1.000 1.000 557 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(6), AKR1D1(8), CYP11A1(9), CYP11B1(8), CYP11B2(8), CYP17A1(3), CYP21A2(6), HSD11B1(6), HSD3B1(3), HSD3B2(6) 3205297 63 29 63 25 17 24 8 1 13 0 0.703 1.000 1.000 558 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(5), FOS(3), HRAS(1), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MYC(8), NFKB1(10), NFKBIA(3), PLCB1(5), PRKCA(11), RAF1(9), RELA(6) 5458669 69 29 68 27 19 21 20 2 7 0 0.738 1.000 1.000 559 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(8), CYSLTR2(5), GPR161(7), GPR171(5), GPR18(3), GPR34(9), GPR39(9), GPR45(3), GPR65(11), GPR68(6), GPR75(8) 3643783 74 29 69 31 28 21 20 0 5 0 0.666 1.000 1.000 560 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(6), AKR1D1(8), CYP11A1(9), CYP11B1(8), CYP11B2(8), CYP17A1(3), CYP21A2(6), HSD11B1(6), HSD3B1(3), HSD3B2(6) 3205297 63 29 63 25 17 24 8 1 13 0 0.703 1.000 1.000 561 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(15), HSD17B1(4), HSD17B2(2), HSD17B3(7), HSD17B4(12), HSD17B7(5), HSD3B1(3), HSD3B2(6) 2949521 57 29 55 21 12 27 6 0 12 0 0.689 1.000 1.000 562 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(11), KHK(2), LCT(32), MPI(5), PGM1(6), PYGL(8), PYGM(10), TPI1(2) 4908197 76 28 76 36 20 29 19 0 8 0 0.928 1.000 1.000 563 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(8), CYP11A1(9), CYP11B2(8), CYP17A1(3), HSD11B1(6), HSD3B1(3), HSD3B2(6) 2498956 43 28 43 19 11 16 8 0 8 0 0.732 1.000 1.000 564 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(11), HK2(9), HK3(9), IMPA1(3), IMPA2(6), ISYNA1(2), PGM1(6), PGM3(3), TGDS(4) 4130241 55 28 55 28 21 15 12 0 7 0 0.915 1.000 1.000 565 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(11), CS(6), MDH1(2), ME1(12), PC(12), PDHA1(7), SLC25A1(2), SLC25A11(3) 3287841 55 28 55 28 15 26 7 1 6 0 0.938 1.000 1.000 566 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(3), DAB1(6), FYN(5), LRP8(4), RELN(48), VLDLR(4) 5115071 72 28 69 32 10 33 19 1 8 1 0.947 1.000 1.000 567 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(6), LDLR(7), MBTPS1(9), MBTPS2(10), SCAP(11), SREBF1(2), SREBF2(13) 4072172 58 28 57 25 22 20 9 0 7 0 0.711 1.000 1.000 568 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(2), B3GALNT1(6), B3GALT5(4), FUT1(4), FUT2(1), FUT9(9), GBGT1(6), GLA(9), HEXA(3), HEXB(5), NAGA(4), ST3GAL1(2), ST3GAL2(6), ST8SIA1(2) 3755630 63 27 59 25 20 26 9 1 7 0 0.657 1.000 1.000 569 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(3), EHHADH(10), HADH(1), HADHA(5), HSD17B10(4), HSD17B4(12), NTAN1(3), SIRT1(6), SIRT2(7), SIRT5(5), SIRT7(6), VNN2(11) 4305314 74 27 72 26 19 31 18 0 6 0 0.714 1.000 1.000 570 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(8), CDC25A(8), CDC25B(3), CDC25C(5), CSK(1), GRB2(3), PRKCA(11), PTPRA(10), SRC(3) 3330501 52 27 51 25 19 10 13 0 10 0 0.936 1.000 1.000 571 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDFT1(1), FDPS(8), HMGCR(12), IDI1(3), LSS(6), MVD(3), MVK(3), NQO1(3), NQO2(5), PMVK(3), SQLE(5), VKORC1(1) 3924470 55 26 53 27 16 22 12 0 5 0 0.938 1.000 1.000 572 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(4), CASP7(1), DFFB(4), ENDOG(1), GZMB(4), HMGB1(4), HMGB2(4), TOP2A(14), TOP2B(24) 3857901 60 26 59 21 9 20 15 0 16 0 0.922 1.000 1.000 573 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(2), FUT1(4), FUT2(1), FUT9(9), GBGT1(6), GLA(9), HEXA(3), HEXB(5), NAGA(4), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), ST8SIA1(2) 3538266 56 26 55 23 18 23 10 1 4 0 0.714 1.000 1.000 574 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(12), PRKCA(11), PTK2B(15) 2445611 41 26 40 24 19 10 9 0 3 0 0.979 1.000 1.000 575 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(7), CS(6), FH(8), IDH2(5), MDH1(2), OGDH(13), SDHA(14), SUCLA2(5) 3504439 60 26 60 25 25 19 12 0 4 0 0.648 1.000 1.000 576 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(3), NFKB1(10), NFKBIA(3), PLCB1(5), PRKCA(11), RELA(6) 2991782 38 26 38 21 10 11 9 2 6 0 0.974 1.000 1.000 577 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(7), MMP2(7), MMP9(12), RECK(13), TIMP1(3), TIMP2(2), TIMP3(7), TIMP4(1) 2748434 53 26 53 23 11 23 11 0 8 0 0.781 1.000 1.000 578 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(14), CD44(5), CSF1(6), FCGR3A(1), IL1B(2), IL6R(7), SELL(5), SPN(1), TGFB1(1), TGFB2(5), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(6), TNFSF8(1) 4738496 60 26 57 30 18 19 13 0 10 0 0.933 1.000 1.000 579 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2) 4869763 56 25 55 22 23 14 11 2 6 0 0.557 1.000 1.000 580 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(6), AASDH(10), AASDHPPT(9), AASS(12), KARS(5) 2587026 42 25 39 19 6 19 12 1 4 0 0.954 1.000 1.000 581 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(11), HK2(9), HK3(9), IMPA1(3), PGM1(6), PGM3(3), TGDS(4) 3696126 47 25 47 23 16 14 11 0 6 0 0.900 1.000 1.000 582 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(4), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), XYLT1(16), XYLT2(4) 2130232 43 24 43 20 21 11 8 0 3 0 0.772 1.000 1.000 583 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(4), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), XYLT1(16), XYLT2(4) 2130232 43 24 43 20 21 11 8 0 3 0 0.772 1.000 1.000 584 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 9 B3GALT1(12), B3GALT2(8), B3GALT5(4), B3GNT5(6), FUT1(4), FUT2(1), FUT3(8), ST3GAL3(6), ST3GAL4(3) 2404103 52 24 50 17 20 15 9 1 7 0 0.418 1.000 1.000 585 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(5), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT5(2), FUT8(10), ST3GAL1(2), ST3GAL2(6), ST3GAL3(6), ST3GAL4(3) 2788833 51 24 49 21 25 12 10 1 3 0 0.802 1.000 1.000 586 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2) 2852783 47 23 46 19 16 17 8 2 4 0 0.589 1.000 1.000 587 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2) 2852783 47 23 46 19 16 17 8 2 4 0 0.589 1.000 1.000 588 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(4), EPHX2(7), HSD3B7(5), RDH11(1), RDH12(5), RDH13(4), RDH14(2) 1698250 28 23 28 12 12 9 4 1 2 0 0.695 1.000 1.000 589 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(6), ACAT2(4), ACYP1(2), ECHS1(3), EHHADH(10), GCDH(4), HADHA(5), SDHB(2), SDS(1) 2849217 37 22 37 14 7 15 11 0 4 0 0.722 1.000 1.000 590 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(5), ACAA2(3), ACAT1(6), ACAT2(4), ECHS1(3), EHHADH(10), HADHA(5), HADHB(4), SDS(1) 3075552 41 22 41 16 11 14 13 0 3 0 0.715 1.000 1.000 591 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(3), ALAS1(8), ALAS2(10), CPOX(6), FECH(7), HMBS(8), UROD(3), UROS(3) 2842724 48 22 46 13 20 16 7 0 5 0 0.399 1.000 1.000 592 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(11), DLL1(6), FURIN(6), NOTCH1(10), PSEN1(5) 2760552 38 22 38 25 14 13 5 0 5 1 0.958 1.000 1.000 593 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB10(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(4), PSMB7(2), PSMB8(1), PSMB9(1) 3015723 40 22 38 14 11 10 7 0 12 0 0.655 1.000 1.000 594 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(5), ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(3), RAC1(1), WASF1(3), WASL(8) 3012972 41 22 41 13 16 16 2 0 7 0 0.467 1.000 1.000 595 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(6), CAMP(1), DAG1(6), GNAQ(3), ITPKA(1), ITPKB(11) 2031746 28 22 28 10 10 13 1 0 4 0 0.472 1.000 1.000 596 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(4), CHAT(5), CHKA(9), PCYT1A(3), PDHA1(7), PDHA2(9), PEMT(1), SLC18A3(6) 2387107 44 21 43 26 9 19 8 1 6 1 0.968 1.000 1.000 597 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), MIOX(5), UGDH(2) 3009817 34 21 33 18 16 11 4 2 1 0 0.856 1.000 1.000 598 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(6), AASDHPPT(9), AASS(12), KARS(5) 1761211 32 21 29 13 6 17 7 1 1 0 0.890 1.000 1.000 599 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 BPNT1(3), CHST11(8), CHST12(3), PAPSS1(8), PAPSS2(7), SULT1A1(3), SULT1A2(1), SULT1E1(9), SULT2A1(7), SULT2B1(4), SUOX(2) 3159305 55 21 51 18 27 20 5 0 3 0 0.442 1.000 1.000 600 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(4), LTB4R(2), P2RY1(3), P2RY2(3), P2RY6(4) 2030439 26 21 26 17 11 6 9 0 0 0 0.953 1.000 1.000 601 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(6), PLCD1(4), PRKCA(11), TGM2(10) 1783266 31 21 31 16 15 7 6 0 3 0 0.830 1.000 1.000 602 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(3), DPM2(1), EGR1(6), HRAS(1), KLK2(2), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NGFR(3), RAF1(9) 2829678 39 20 38 19 19 11 7 0 2 0 0.763 1.000 1.000 603 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(9), PARK2(5), SNCA(3), SNCAIP(10), UBE2E2(3), UBE2F(1), UBE2G1(2), UBE2L3(2), UBE2L6(3) 2308876 38 20 38 16 9 17 8 0 3 1 0.787 1.000 1.000 604 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 6 FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), ST3GAL3(6) 1510570 30 19 30 13 18 9 1 0 2 0 0.545 1.000 1.000 605 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(11), GLS2(7), GLUD1(3), GLUD2(9) 1620963 30 19 29 14 9 9 6 0 6 0 0.936 1.000 1.000 606 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(4), CD36(8), FOS(3), FYN(5), JUN(1), MAPK14(4), THBS1(10) 2646788 35 19 35 14 10 10 7 0 8 0 0.724 1.000 1.000 607 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(8), ACADM(9), ACADS(3), ACAT1(6), ECHS1(3), HADHA(5) 1930428 34 18 34 12 6 14 11 0 3 0 0.689 1.000 1.000 608 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(8), CYCS(2), GPD2(3), NDUFA1(1), SDHA(14), SDHB(2), SDHC(2), SDHD(3), UQCRC1(2) 2400407 37 18 37 12 17 10 6 0 4 0 0.518 1.000 1.000 609 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), DHFR(4), FPGS(5), GCH1(1), GGH(2), SPR(1) 2130667 28 18 28 13 11 11 4 0 2 0 0.652 1.000 1.000 610 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(11), CYP2E1(2), NR1I3(4), PTGS1(5), PTGS2(9) 1942207 31 17 30 10 12 9 6 1 3 0 0.539 1.000 1.000 611 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(4), CASP8(21), CFL1(1), CFLAR(2), PDE6D(2) 1403178 30 17 28 10 4 12 5 0 9 0 0.683 1.000 1.000 612 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(3), PAPSS1(8), PAPSS2(7), SULT1A2(1), SULT1E1(9), SULT2A1(7), SUOX(2) 2256029 37 17 34 11 18 13 3 0 3 0 0.622 1.000 1.000 613 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(3), EHHADH(10), HADHA(5), SDS(1) 1772376 20 16 20 16 3 9 7 0 1 0 0.997 1.000 1.000 614 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(3), CD4(6), CD80(5), HLA-DRA(1), IL10(4), IL2(2), IL4(1) 1330988 22 15 22 10 5 8 3 1 5 0 0.847 1.000 1.000 615 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(18), PDXK(4), PNPO(1), PSAT1(5) 1718955 28 15 28 12 6 13 4 0 5 0 0.790 1.000 1.000 616 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(4), GGT1(5), SHMT1(5), SHMT2(5) 2046382 19 14 19 10 7 8 2 0 2 0 0.827 1.000 1.000