E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.016 0.092 -9999.0 0.0 -0.272 59.0 59.0 KLHL20 -0.005 0.062 0.2 2.0 -0.204 26.0 28.0 CYFIP2 0.021 0.028 -9999.0 0.0 -0.35 3.0 3.0 Rac1/GDP 0.001 0.069 0.247 3.0 -0.285 5.0 8.0 ENAH -0.019 0.093 -9999.0 0.0 -0.275 60.0 60.0 AP1M1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.014 0.028 -9999.0 0.0 -0.216 1.0 1.0 ABI1/Sra1/Nap1 -0.013 0.037 -9999.0 0.0 -0.141 27.0 27.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.028 -9999.0 0.0 -0.191 2.0 2.0 RAPGEF1 -0.011 0.08 0.224 2.0 -0.314 9.0 11.0 CTNND1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.012 0.101 -9999.0 0.0 -0.28 65.0 65.0 CRK -0.009 0.082 -9999.0 0.0 -0.269 40.0 40.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.027 -9999.0 0.0 -0.287 2.0 2.0 alphaE/beta7 Integrin 0.032 0.013 0.209 1.0 -9999.0 0.0 1.0 IQGAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.042 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.013 0.087 -9999.0 0.0 -0.275 51.0 51.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.016 -9999.0 0.0 -0.145 2.0 2.0 MLLT4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.036 -9999.0 0.0 -0.185 12.0 12.0 PI3K -0.019 0.02 -9999.0 0.0 -0.209 1.0 1.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.028 0.027 -9999.0 0.0 -0.345 2.0 2.0 TIAM1 0.014 0.057 -9999.0 0.0 -0.35 13.0 13.0 E-cadherin(dimer)/Ca2+ 0.046 0.024 -9999.0 0.0 -0.17 2.0 2.0 AKT1 -0.011 0.021 -9999.0 0.0 -0.126 1.0 1.0 PIK3R1 0.018 0.036 -9999.0 0.0 -0.35 5.0 5.0 CDH1 0.019 0.024 -9999.0 0.0 -0.35 2.0 2.0 RhoA/GDP 0.001 0.068 0.231 1.0 -0.272 5.0 6.0 actin cytoskeleton organization -0.002 0.048 0.173 3.0 -0.151 24.0 27.0 CDC42/GDP 0.003 0.069 0.247 3.0 -0.276 6.0 9.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.022 -9999.0 0.0 -0.325 2.0 2.0 ITGB7 0.023 0.011 0.279 1.0 -9999.0 0.0 1.0 RAC1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.026 -9999.0 0.0 -0.182 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.019 -9999.0 0.0 -0.166 2.0 2.0 mol:GDP -0.01 0.074 0.254 3.0 -0.301 8.0 11.0 CDC42/GTP/IQGAP1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.017 -9999.0 0.0 -0.35 1.0 1.0 p120 catenin/RhoA/GDP 0.008 0.069 0.235 1.0 -0.28 4.0 5.0 RAC1/GTP/IQGAP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.004 0.037 0.147 7.0 -0.106 2.0 9.0 NME1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.01 0.084 -9999.0 0.0 -0.272 49.0 49.0 regulation of cell-cell adhesion 0.008 0.023 -9999.0 0.0 -0.191 1.0 1.0 WASF2 -0.001 0.025 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.017 0.038 -9999.0 0.0 -0.237 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.034 -9999.0 0.0 -0.339 1.0 1.0 CCND1 0.004 0.043 0.176 6.0 -0.128 2.0 8.0 VAV2 -0.029 0.164 -9999.0 0.0 -0.581 32.0 32.0 RAP1/GDP 0.018 0.06 0.251 4.0 -0.256 4.0 8.0 adherens junction assembly -0.011 0.085 -9999.0 0.0 -0.265 51.0 51.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.041 0.029 -9999.0 0.0 -0.329 1.0 1.0 E-cadherin/beta catenin 0.008 0.019 -9999.0 0.0 -0.29 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.016 0.092 -9999.0 0.0 -0.275 58.0 58.0 PIK3CA 0.02 0.018 -9999.0 0.0 -0.35 1.0 1.0 Rac1/GTP -0.018 0.086 0.182 1.0 -0.315 29.0 30.0 E-cadherin/beta catenin/alpha catenin 0.039 0.022 -9999.0 0.0 -0.198 2.0 2.0 ITGAE 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.013 0.102 -9999.0 0.0 -0.285 65.0 65.0