Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Aurora B signaling	191.0	12838.0	67.0	-0.289	0.368	1000.0	-1000.0	-0.032	-1000.0
Endothelins	126.0	12152.0	96.0	-0.396	0.161	1000.0	-1000.0	-0.033	-1000.0
Aurora C signaling	122.0	855.0	7.0	-0.0	0.227	1000.0	-1000.0	-0.007	-1000.0
Signaling events regulated by Ret tyrosine kinase	109.0	8967.0	82.0	-0.145	0.038	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	106.0	9414.0	88.0	-0.303	0.112	1000.0	-1000.0	-0.049	-1000.0
p75(NTR)-mediated signaling	100.0	12504.0	125.0	-0.166	0.075	1000.0	-1000.0	-0.045	-1000.0
FOXM1 transcription factor network	95.0	4871.0	51.0	-0.286	0.273	1000.0	-1000.0	-0.067	-1000.0
PDGFR-alpha signaling pathway	87.0	3867.0	44.0	-0.28	0.037	1000.0	-1000.0	-0.029	-1000.0
Integrins in angiogenesis	81.0	6854.0	84.0	-0.26	0.096	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by the Hedgehog family	80.0	4198.0	52.0	-0.201	0.11	1000.0	-1000.0	-0.017	-1000.0
HIF-1-alpha transcription factor network	80.0	6144.0	76.0	-0.249	0.044	1000.0	-1000.0	-0.027	-1000.0
PLK1 signaling events	78.0	6697.0	85.0	-0.056	0.25	1000.0	-1000.0	-0.027	-1000.0
Reelin signaling pathway	77.0	4344.0	56.0	-0.116	0.045	1000.0	-1000.0	-0.02	-1000.0
Cellular roles of Anthrax toxin	70.0	2732.0	39.0	-0.093	0.053	1000.0	-1000.0	-0.014	-1000.0
S1P3 pathway	65.0	2742.0	42.0	-0.391	0.031	1000.0	-1000.0	-0.021	-1000.0
Nongenotropic Androgen signaling	62.0	3229.0	52.0	-0.235	0.138	1000.0	-1000.0	-0.025	-1000.0
Fc-epsilon receptor I signaling in mast cells	59.0	5803.0	97.0	-0.096	0.024	1000.0	-1000.0	-0.046	-1000.0
Aurora A signaling	58.0	3515.0	60.0	-0.137	0.219	1000.0	-1000.0	-0.017	-1000.0
Effects of Botulinum toxin	58.0	1516.0	26.0	-0.102	0.114	1000.0	-1000.0	-0.01	-1000.0
Wnt signaling	56.0	396.0	7.0	-0.065	0.037	1000.0	-1000.0	-0.005	-1000.0
IGF1 pathway	54.0	3117.0	57.0	-0.076	0.035	1000.0	-1000.0	-0.021	-1000.0
Signaling mediated by p38-alpha and p38-beta	53.0	2333.0	44.0	-0.079	0.023	1000.0	-1000.0	-0.017	-1000.0
LPA4-mediated signaling events	51.0	622.0	12.0	-0.11	0.0	1000.0	-1000.0	-0.014	-1000.0
TCGA08_p53	51.0	357.0	7.0	-0.033	0.019	1000.0	-1000.0	-0.01	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	50.0	6003.0	120.0	-0.152	0.114	1000.0	-1000.0	-0.03	-1000.0
Ephrin B reverse signaling	49.0	2363.0	48.0	-0.095	0.028	1000.0	-1000.0	-0.026	-1000.0
Glypican 1 network	48.0	2306.0	48.0	-0.169	0.103	1000.0	-1000.0	-0.021	-1000.0
TCGA08_retinoblastoma	45.0	367.0	8.0	-0.04	0.13	1000.0	-1000.0	-0.005	-1000.0
Noncanonical Wnt signaling pathway	44.0	1154.0	26.0	-0.122	0.037	1000.0	-1000.0	-0.028	-1000.0
Thromboxane A2 receptor signaling	44.0	4683.0	105.0	-0.136	0.048	1000.0	-1000.0	-0.03	-1000.0
FOXA2 and FOXA3 transcription factor networks	42.0	1971.0	46.0	-0.197	0.191	1000.0	-1000.0	-0.075	-1000.0
S1P4 pathway	42.0	1055.0	25.0	-0.065	0.038	1000.0	-1000.0	-0.013	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	41.0	1423.0	34.0	-0.017	0.029	1000.0	-1000.0	-0.021	-1000.0
BMP receptor signaling	41.0	3362.0	81.0	-0.231	0.043	1000.0	-1000.0	-0.019	-1000.0
Osteopontin-mediated events	40.0	1529.0	38.0	-0.089	0.097	1000.0	-1000.0	-0.019	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	40.0	2775.0	68.0	-0.149	0.074	1000.0	-1000.0	-0.072	-1000.0
Plasma membrane estrogen receptor signaling	40.0	3516.0	86.0	-0.192	0.08	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	40.0	3175.0	78.0	-0.134	0.055	1000.0	-1000.0	-0.034	-1000.0
S1P1 pathway	39.0	1411.0	36.0	-0.152	0.022	1000.0	-1000.0	-0.016	-1000.0
Syndecan-1-mediated signaling events	38.0	1293.0	34.0	-0.05	0.157	1000.0	-1000.0	-0.021	-1000.0
amb2 Integrin signaling	38.0	3171.0	82.0	-0.105	0.128	1000.0	-1000.0	-0.021	-1000.0
Ephrin A  reverse signaling	37.0	262.0	7.0	-0.027	0.012	1000.0	-1000.0	-0.006	-1000.0
LPA receptor mediated events	37.0	3809.0	102.0	-0.134	0.128	1000.0	-1000.0	-0.052	-1000.0
EPHB forward signaling	35.0	3057.0	85.0	-0.055	0.048	1000.0	-1000.0	-0.044	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	34.0	2947.0	85.0	-0.21	0.031	1000.0	-1000.0	-0.041	-1000.0
Ras signaling in the CD4+ TCR pathway	33.0	570.0	17.0	-0.091	0.023	1000.0	-1000.0	-0.019	-1000.0
IL4-mediated signaling events	32.0	2972.0	91.0	-0.303	0.094	1000.0	-1000.0	-0.077	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	30.0	1627.0	54.0	-0.101	0.048	1000.0	-1000.0	-0.02	-1000.0
Arf6 signaling events	30.0	1862.0	62.0	-0.063	0.043	1000.0	-1000.0	-0.041	-1000.0
Visual signal transduction: Rods	30.0	1604.0	52.0	-0.057	0.113	1000.0	-1000.0	-0.015	-1000.0
HIF-2-alpha transcription factor network	29.0	1261.0	43.0	-0.164	0.075	1000.0	-1000.0	-0.039	-1000.0
FAS signaling pathway (CD95)	29.0	1391.0	47.0	-0.05	0.038	1000.0	-1000.0	-0.03	-1000.0
EGFR-dependent Endothelin signaling events	29.0	618.0	21.0	-0.082	0.048	1000.0	-1000.0	-0.027	-1000.0
Glucocorticoid receptor regulatory network	27.0	3191.0	114.0	-0.15	0.206	1000.0	-1000.0	-0.036	-1000.0
S1P5 pathway	27.0	474.0	17.0	-0.065	0.036	1000.0	-1000.0	-0.005	-1000.0
Glypican 2 network	27.0	108.0	4.0	0.023	0.043	1000.0	-1000.0	0.019	-1000.0
Syndecan-4-mediated signaling events	27.0	1845.0	67.0	-0.205	0.128	1000.0	-1000.0	-0.026	-1000.0
Coregulation of Androgen receptor activity	26.0	1998.0	76.0	-0.09	0.125	1000.0	-1000.0	-0.022	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	26.0	1377.0	52.0	-0.055	0.047	1000.0	-1000.0	-0.028	-1000.0
Calcium signaling in the CD4+ TCR pathway	26.0	819.0	31.0	-0.09	0.042	1000.0	-1000.0	-0.033	-1000.0
Visual signal transduction: Cones	25.0	958.0	38.0	-0.057	0.033	1000.0	-1000.0	-0.013	-1000.0
Syndecan-2-mediated signaling events	25.0	1744.0	69.0	-0.01	0.103	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by PTP1B	25.0	1900.0	76.0	-0.086	0.037	1000.0	-1000.0	-0.034	-1000.0
Presenilin action in Notch and Wnt signaling	25.0	1547.0	61.0	-0.089	0.083	1000.0	-1000.0	-0.029	-1000.0
TCR signaling in naïve CD8+ T cells	25.0	2377.0	93.0	-0.015	0.053	1000.0	-1000.0	-0.032	-1000.0
Insulin Pathway	25.0	1914.0	74.0	-0.096	0.112	1000.0	-1000.0	-0.032	-1000.0
IL12-mediated signaling events	24.0	2153.0	87.0	-0.296	0.061	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	24.0	3119.0	125.0	-0.056	0.044	1000.0	-1000.0	-0.022	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	23.0	771.0	33.0	-0.122	0.126	1000.0	-1000.0	-0.02	-1000.0
IL2 signaling events mediated by STAT5	22.0	505.0	22.0	-0.095	0.077	1000.0	-1000.0	-0.026	-1000.0
BARD1 signaling events	21.0	1202.0	57.0	-0.045	0.131	1000.0	-1000.0	-0.035	-1000.0
Canonical Wnt signaling pathway	21.0	1110.0	51.0	-0.046	0.083	1000.0	-1000.0	-0.027	-1000.0
TCGA08_rtk_signaling	21.0	569.0	26.0	-0.096	0.032	1000.0	-1000.0	-0.013	-1000.0
IL6-mediated signaling events	21.0	1581.0	75.0	-0.088	0.09	1000.0	-1000.0	-0.031	-1000.0
BCR signaling pathway	21.0	2099.0	99.0	-0.035	0.058	1000.0	-1000.0	-0.034	-1000.0
Regulation of Androgen receptor activity	21.0	1517.0	70.0	-0.038	0.19	1000.0	-1000.0	-0.034	-1000.0
EPO signaling pathway	20.0	1139.0	55.0	-0.04	0.038	1000.0	-1000.0	-0.023	-1000.0
Class I PI3K signaling events mediated by Akt	20.0	1361.0	68.0	-0.082	0.206	1000.0	-1000.0	-0.019	-1000.0
Regulation of p38-alpha and p38-beta	20.0	1101.0	54.0	-0.135	0.054	1000.0	-1000.0	-0.043	-1000.0
Hedgehog signaling events mediated by Gli proteins	18.0	1224.0	65.0	-0.096	0.052	1000.0	-1000.0	-0.033	-1000.0
IFN-gamma pathway	18.0	1265.0	68.0	-0.181	0.074	1000.0	-1000.0	-0.032	-1000.0
Retinoic acid receptors-mediated signaling	18.0	1081.0	58.0	-0.018	0.05	1000.0	-1000.0	-0.024	-1000.0
Rapid glucocorticoid signaling	18.0	365.0	20.0	-0.031	0.026	1000.0	-1000.0	-0.007	-1000.0
Regulation of nuclear SMAD2/3 signaling	17.0	2368.0	136.0	-0.088	0.138	1000.0	-1000.0	-0.027	-1000.0
mTOR signaling pathway	17.0	924.0	53.0	-0.029	0.025	1000.0	-1000.0	-0.026	-1000.0
Sphingosine 1-phosphate (S1P) pathway	16.0	451.0	28.0	-0.065	0.041	1000.0	-1000.0	-0.016	-1000.0
Insulin-mediated glucose transport	16.0	534.0	32.0	-0.085	0.206	1000.0	-1000.0	-0.015	-1000.0
Nectin adhesion pathway	16.0	1062.0	63.0	-0.04	0.054	1000.0	-1000.0	-0.046	-1000.0
Syndecan-3-mediated signaling events	16.0	586.0	35.0	-0.06	0.095	1000.0	-1000.0	-0.014	-1000.0
IL2 signaling events mediated by PI3K	16.0	928.0	58.0	-0.03	0.116	1000.0	-1000.0	-0.023	-1000.0
Regulation of Telomerase	16.0	1679.0	102.0	-0.241	0.087	1000.0	-1000.0	-0.034	-1000.0
ErbB2/ErbB3 signaling events	15.0	1027.0	65.0	-0.076	0.048	1000.0	-1000.0	-0.054	-1000.0
JNK signaling in the CD4+ TCR pathway	15.0	255.0	17.0	-0.044	0.056	1000.0	-1000.0	-0.025	-1000.0
Ceramide signaling pathway	15.0	1148.0	76.0	-0.046	0.061	1000.0	-1000.0	-0.017	-1000.0
FoxO family signaling	15.0	1010.0	64.0	-0.016	0.206	1000.0	-1000.0	-0.031	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	14.0	1171.0	83.0	-0.023	0.206	1000.0	-1000.0	-0.023	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	14.0	655.0	45.0	-0.006	0.058	1000.0	-1000.0	-0.025	-1000.0
PDGFR-beta signaling pathway	14.0	1428.0	97.0	-0.021	0.05	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by PRL	14.0	485.0	34.0	-0.036	0.091	1000.0	-1000.0	-0.037	-1000.0
Caspase cascade in apoptosis	13.0	1028.0	74.0	-0.027	0.149	1000.0	-1000.0	-0.021	-1000.0
ErbB4 signaling events	13.0	918.0	69.0	-0.05	0.054	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	13.0	816.0	62.0	-0.014	0.067	1000.0	-1000.0	-0.021	-1000.0
IL23-mediated signaling events	13.0	805.0	60.0	-0.007	0.232	1000.0	-1000.0	-0.078	-1000.0
ceramide signaling pathway	12.0	635.0	49.0	-0.008	0.054	1000.0	-1000.0	-0.024	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	11.0	418.0	37.0	-0.021	0.063	1000.0	-1000.0	-0.023	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	866.0	74.0	-0.05	0.077	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by HDAC Class III	10.0	402.0	40.0	-0.054	0.04	1000.0	-1000.0	-0.03	-1000.0
IL27-mediated signaling events	10.0	528.0	51.0	-0.033	0.038	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling in the nascent adherens junction	10.0	783.0	76.0	-0.029	0.056	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in keratinocytes	10.0	452.0	43.0	-0.009	0.038	1000.0	-1000.0	-0.021	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.022	0.022	1000.0	-1000.0	-0.017	-1000.0
Canonical NF-kappaB pathway	9.0	388.0	39.0	-0.008	0.053	1000.0	-1000.0	-0.019	-1000.0
p38 MAPK signaling pathway	8.0	355.0	44.0	-0.002	0.063	1000.0	-1000.0	-0.013	-1000.0
Signaling events mediated by HDAC Class II	7.0	572.0	75.0	-0.031	0.045	1000.0	-1000.0	-0.023	-1000.0
Arf6 trafficking events	7.0	531.0	71.0	-0.157	0.04	1000.0	-1000.0	-0.027	-1000.0
Class I PI3K signaling events	6.0	466.0	73.0	-0.023	0.042	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class I	5.0	549.0	104.0	-0.035	0.057	1000.0	-1000.0	-0.032	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	-0.011	0.025	1000.0	-1000.0	-0.017	-1000.0
TRAIL signaling pathway	4.0	234.0	48.0	-0.01	0.05	1000.0	-1000.0	-0.017	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	67.0	15.0	-0.011	0.022	1000.0	-1000.0	-0.022	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	177.0	36.0	-0.041	0.043	1000.0	-1000.0	-0.023	-1000.0
VEGFR1 specific signals	4.0	239.0	56.0	-0.04	0.047	1000.0	-1000.0	-0.028	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	78.0	23.0	0.002	0.046	1000.0	-1000.0	-0.011	-1000.0
Arf6 downstream pathway	3.0	163.0	43.0	-0.037	0.041	1000.0	-1000.0	-0.023	-1000.0
Arf1 pathway	3.0	185.0	54.0	-0.005	0.041	1000.0	-1000.0	-0.01	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	10.0	5.0	0.022	0.034	1000.0	-1000.0	0.016	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	2.0	63.0	27.0	-0.014	0.054	1000.0	-1000.0	-0.028	-1000.0
Atypical NF-kappaB pathway	1.0	44.0	31.0	-0.011	0.027	1000.0	-1000.0	-0.017	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	0.019	0.038	1000.0	-1000.0	0.013	-1000.0
Circadian rhythm pathway	0.0	19.0	22.0	-0.006	0.048	1000.0	-1000.0	-0.02	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.0	0.059	1000.0	-1000.0	-0.0	-1000.0
Total	4221	253571	7203	-11.7082680564	10.3455851889	131000	-131000	-3.48482854228	-131000