Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.134 0.191 -9999.0 0.0 -0.46 11.0 11.0 IHH -0.111 0.165 -9999.0 0.0 -0.297 21.0 21.0 SHH Np/Cholesterol/GAS1 -0.056 0.095 -9999.0 0.0 -0.183 16.0 16.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.055 0.095 0.182 16.0 -9999.0 0.0 16.0 SMO/beta Arrestin2 -0.137 0.185 -9999.0 0.0 -0.394 13.0 13.0 SMO -0.15 0.193 -9999.0 0.0 -0.401 15.0 15.0 AKT1 -0.083 0.153 -9999.0 0.0 -0.518 4.0 4.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.017 0.081 -9999.0 0.0 -0.212 8.0 8.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.148 0.19 -9999.0 0.0 -0.396 15.0 15.0 STIL -0.101 0.136 -9999.0 0.0 -0.285 15.0 15.0 DHH N/PTCH2 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.097 0.131 -9999.0 0.0 -0.3 11.0 11.0 PIK3CA 0.01 0.049 -9999.0 0.0 -0.345 1.0 1.0 DHH 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.169 0.231 -9999.0 0.0 -0.546 11.0 11.0 determination of left/right symmetry -0.148 0.19 -9999.0 0.0 -0.396 15.0 15.0 PIK3R1 -0.027 0.108 -9999.0 0.0 -0.278 8.0 8.0 skeletal system development -0.168 0.229 -9999.0 0.0 -0.541 11.0 11.0 IHH N/Hhip -0.14 0.132 -9999.0 0.0 -0.244 29.0 29.0 DHH N/Hhip -0.021 0.089 -9999.0 0.0 -0.23 6.0 6.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.148 0.19 -9999.0 0.0 -0.396 15.0 15.0 pancreas development -0.049 0.126 -9999.0 0.0 -0.278 12.0 12.0 HHAT -0.041 0.13 -9999.0 0.0 -0.33 9.0 9.0 PI3K -0.01 0.091 -9999.0 0.0 -0.207 8.0 8.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.082 0.144 -9999.0 0.0 -0.278 18.0 18.0 somite specification -0.148 0.19 -9999.0 0.0 -0.396 15.0 15.0 SHH Np/Cholesterol/PTCH1 -0.105 0.139 -9999.0 0.0 -0.299 14.0 14.0 SHH Np/Cholesterol/PTCH2 -0.005 0.069 -9999.0 0.0 -0.165 8.0 8.0 SHH Np/Cholesterol/Megalin -0.013 0.076 -9999.0 0.0 -0.178 8.0 8.0 SHH -0.02 0.09 -9999.0 0.0 -0.219 9.0 9.0 catabolic process -0.118 0.146 -9999.0 0.0 -0.344 11.0 11.0 SMO/Vitamin D3 -0.128 0.169 -9999.0 0.0 -0.353 15.0 15.0 SHH Np/Cholesterol/Hhip -0.039 0.09 -9999.0 0.0 -0.179 13.0 13.0 LRP2 -0.0 0.06 -9999.0 0.0 -0.212 4.0 4.0 receptor-mediated endocytosis -0.12 0.165 -9999.0 0.0 -0.37 11.0 11.0 SHH Np/Cholesterol/BOC -0.021 0.086 -9999.0 0.0 -0.203 8.0 8.0 SHH Np/Cholesterol/CDO -0.013 0.076 -9999.0 0.0 -0.178 8.0 8.0 mesenchymal cell differentiation 0.039 0.09 0.178 13.0 -9999.0 0.0 13.0 mol:Vitamin D3 -0.105 0.14 -9999.0 0.0 -0.301 14.0 14.0 IHH N/PTCH2 -0.094 0.105 -9999.0 0.0 -0.208 22.0 22.0 CDON -0.0 0.06 -9999.0 0.0 -0.212 4.0 4.0 IHH N/PTCH1 -0.118 0.15 -9999.0 0.0 -0.347 11.0 11.0 Megalin/LRPAP1 0.013 0.041 -9999.0 0.0 -0.131 4.0 4.0 PTCH2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.014 0.067 -9999.0 0.0 -0.171 8.0 8.0 PTCH1 -0.119 0.147 -9999.0 0.0 -0.345 11.0 11.0 HHIP -0.049 0.127 -9999.0 0.0 -0.278 12.0 12.0