Hybridization REF p difference q subclass Composite Element REF p difference q subclass AKT1 AKT2 AKT3|AKT_PS473 1.92139553448308e-47 1.75768782727796 9.75108233750163e-46 1 AKT1 AKT2 AKT3|AKT_PT308 4.20024449504504e-43 1.48138621615444 1.70529926498829e-41 1 ESR1|ER-ALPHA 5.67609650233227e-19 1.27494736046873 7.20154743733407e-18 1 MAPK1 MAPK3|MAPK_PT202_Y204 3.07938296688908e-38 1.10848766975345 8.93021060397833e-37 1 MAPK14|P38_PT180_Y182 2.67633189059567e-50 1.01209048101826 2.71647686895461e-48 1 PDCD4|PDCD4 5.65377393618768e-35 0.980332385495538 1.43464513630762e-33 1 GSK3A GSK3B|GSK3_PS9 2.83931251036895e-53 0.97501854492869 5.76380439604897e-51 1 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 1.18458612123964e-49 0.96661547451587 8.01569942038823e-48 1 SRC|SRC_PY527 3.72673736392694e-28 0.780755845919832 6.87752440797426e-27 1 RPS6|S6_PS235_S236 3.08896361629779e-18 0.703037954666955 3.68858596534383e-17 1 MYH11|MYH11 0.00532269508806285 0.621177927129691 0.00892981076757652 1 PRKCB|PKC-PAN_BETAII_PS660 3.02234189120244e-42 0.613891478383385 1.02255900652349e-40 1 NFKB1|NF-KB-P65_PS536 3.3105125243153e-14 0.606219229468145 2.68813616974402e-13 1 MAP2K1|MEK1_PS217_S221 9.75206292018065e-27 0.586043268319512 1.64972397733056e-25 1 ESR1|ER-ALPHA_PS118 1.24429792181197e-14 0.547775544264759 1.12519874943787e-13 1 TSC2|TUBERIN_PT1462 8.46783526189035e-34 0.5389612040667 1.9099672868486e-32 1 RB1|RB_PS807_S811 8.10942684376938e-15 0.538747488640445 7.83911261564373e-14 1 NDRG1|NDRG1_PT346 2.87346317204747e-08 0.510602500453664 1.04163039986721e-07 1 CTNNB1|BETA-CATENIN 3.78524968844074e-08 0.479837352153521 1.32483739095426e-07 1 CDH1|E-CADHERIN 1.16335791650867e-08 0.475916630151984 4.37336401946778e-08 1 RPS6|S6_PS240_S244 7.21812903400237e-09 0.440641024391557 2.87309841941663e-08 1 EIF4EBP1|4E-BP1_PT37_T46 1.68629743801691e-12 0.41176371028022 1.14106126639144e-11 1 YAP1|YAP_PS127 2.13590237293507e-13 0.405338931110209 1.605882154466e-12 1 AKT1S1|PRAS40_PT246 8.97357212758278e-32 0.358231497034633 1.8216351418993e-30 1 PRKAA1|AMPK_PT172 1.95197223800817e-07 0.344470547128416 6.09615945101013e-07 1 SRC|SRC_PY416 7.77445508901492e-11 0.334561085577618 4.04670354633341e-10 1 RICTOR|RICTOR 0.0063434883315972 0.311799438109163 0.0102684981932372 1 ACACA ACACB|ACC_PS79 3.69762144204026e-07 0.308728526847166 1.12032410855847e-06 1 BAD|BAD_PS112 2.05055454924895e-23 0.296391239512373 3.2020197961349e-22 1 STAT3|STAT3_PY705 2.46692708175439e-09 0.290788987980665 1.00157239519228e-08 1 CLDN7|CLAUDIN-7 0.00217516056650979 0.28616696835877 0.00390758933629635 1 RPS6KA1|P90RSK_PT359_S363 1.23634391204211e-11 0.282549499217753 7.60538830741056e-11 1 ANXA1|ANNEXIN-1 0.00552022014555171 0.274654163630312 0.00911060723208941 1 AR|AR 0.000244215098764869 0.259539214090498 0.0005058741331558 1 PRKCA |PKC-ALPHA_PS657 0.000877697727209126 0.25202248127705 0.00168087394927785 1 SYK|SYK 0.000289277362915334 0.23924366001283 0.000593164693654675 1 MTOR|MTOR_PS2448 3.59329004879728e-20 0.235686172200526 4.86291919937232e-19 1 YBX1|YB-1_PS102 1.9168931010114e-11 0.229133347981711 1.14449793972151e-10 1 TSC2|TUBERIN 1.76634598853459e-07 0.228292510811503 5.69155929638924e-07 1 PRKAA1|AMPK_ALPHA 5.45371657146373e-11 0.227668767138092 2.91343280001878e-10 1 EGFR|EGFR_PY1068 1.37543542686046e-06 0.220844406929279 3.93258298102357e-06 1 STAT5A|STAT5-ALPHA 0.00252430264224788 0.209475078454253 0.00445594292501147 1 PRKCA |PKC-ALPHA 0.0135243859195321 0.19453495125505 0.0206424837719174 1 TP53BP1|53BP1 0.0033375029285475 0.168010077443923 0.00570654878015635 1 ATM|ATM 0.0385067389328433 0.166860487257469 0.0535401918038849 1 FOXO3|FOXO3A_PS318_S321 1.603932512224e-13 0.165669995570917 1.25230115377489e-12 1 MAPK8|JNK_PT183_PY185 2.57504735508133e-07 0.152875094913131 7.92022141032591e-07 1 RAB25|RAB25 0.0156719345523375 0.14897229318938 0.0235659460305519 1 JUN|C-JUN_PS73 3.70502607072917e-06 0.144054111559444 1.01637877345679e-05 1 CHEK1|CHK1_PS345 7.61073909594982e-08 0.141772856204645 2.57496672746302e-07 1 AKT1 AKT2 AKT3|AKT 0.000467742978851968 0.13781831046504 0.000921862375795626 1 SHC1|SHC_PY317 2.13671797966633e-05 0.126304253034208 5.28967987649104e-05 1 RICTOR|RICTOR_PT1135 2.40531770362771e-10 0.12477667243513 1.13553370659634e-09 1 PDK1|PDK1_PS241 9.00375259914338e-05 0.124406827810326 0.000200852942596275 1 RPS6KA1|P90RSK 0.00116694212730165 0.115730774966119 0.00219341899853921 1 NF2|NF2 0.00637355060269897 0.105778409557417 0.0102684981932372 1 CDK1|CDK1_PY15 0.00951383010057615 0.102395492514096 0.0151715160318657 1 EIF4EBP1|4E-BP1_PS65 0.00536914531233336 0.0976556424983819 0.00893390572462026 1 PRKCD|PKC-DELTA_PS664 9.11610103778929e-05 0.0907935617503433 0.000201148751159916 1 MTOR|MTOR 0.00309921773635397 0.0792480218478851 0.00537727521777655 1 MAPK9|JNK2 0.0478496082490967 0.0675262627498202 0.0660780304392288 1 RAF1|C-RAF_PS338 4.56851974376317e-05 0.0658614454373856 0.000107838314881852 1 CDKN1B|P27_PT157 2.15292940233922e-06 -0.052865215259071 5.98691326951865e-06 1 ERBB3|HER3_PY1289 0.000347680221182323 -0.059436822606809 0.000691951812745212 1 STK11|LKB1 0.00152971403108406 -0.0597664144791612 0.00279758511991049 1 ACVRL1|ACVRL1 0.0172784333712791 -0.0618456227367776 0.0256023501778807 1 ANXA7|ANNEXIN_VII 0.00956627611861485 -0.0646731912765265 0.0151715160318657 1 SMAD3|SMAD3 0.0120897299848597 -0.0695225362113134 0.0188100858846974 1 PARK7|DJ-1 0.0121385283295338 -0.0717875806132486 0.0188100858846974 1 MYH9|MYOSIN-IIA 0.0372656244684557 -0.0757523632827353 0.052171874255838 1 RB1|RB 0.0166850980507342 -0.0763434332132093 0.0249049625316106 1 GSK3A GSK3B|GSK3-ALPHA-BETA 0.000959812353993921 -0.0767498541005655 0.0018209524099137 1 EIF4EBP1|4E-BP1_PT70 8.08773679276456e-05 -0.0802331328952504 0.000182423396547912 1 FOXO3|FOXO3A 1.90619377324607e-05 -0.0813608707186356 4.77725106134509e-05 1 DIRAS3|ARHI 0.00334521825043648 -0.0819792737437729 0.00570654878015635 1 MET|C-MET_PY1235 4.58013700419111e-10 -0.0850890686932695 2.06615069300177e-09 1 RAB11A RAB11B|RAB11 0.000341588274350256 -0.0873360103360519 0.000686558610822792 1 SCD|SCD 1.74454410272029e-05 -0.0900073344862546 4.42678066065274e-05 1 EGFR|EGFR_PY1173 6.88980548924983e-10 -0.0902280427276902 3.04050111808199e-09 1 BAP1|BAP1-C-4 0.013129539359215 -0.092318396640151 0.0201916400751564 1 XBP1|XBP1 0.000190191363819245 -0.0966585115238134 0.000402175488076112 1 BECN1|BECLIN 8.04471000647158e-09 -0.0975171432865618 3.14053102175717e-08 1 BAK1|BAK 0.0326568747068813 -0.0981923689528145 0.0466855321513866 1 GATA6|GATA6 0.00152328094990518 -0.0999045652879388 0.00279758511991049 1 SRSF1|SF2 7.1697620901431e-07 -0.099969575906299 2.0792310061415e-06 1 BID|BID 4.01098522780307e-07 -0.103898501676402 1.19739706065298e-06 1 CHEK1|CHK1 9.11926231539357e-06 -0.107024703374559 2.37334647439089e-05 1 CDKN1A|P21 0.00455021355869017 -0.107292696977854 0.00769744460345087 1 XRCC1|XRCC1 9.23683336850747e-05 -0.107694645067485 0.000201621201484625 1 YWHAE|14-3-3_EPSILON 2.3422478220197e-11 -0.111158498822552 1.35850373677143e-10 1 PREX1|PREX1 0.0216658328951346 -0.112627562025938 0.0316414681849808 1 ERCC1|ERCC1 0.000238260470254569 -0.113850453177971 0.00049862758207915 1 YWHAB|14-3-3_BETA 2.77892089862061e-11 -0.114074079849356 1.56700261783329e-10 1 MRE11A|MRE11 3.11370879424426e-13 -0.115813296857332 2.17959615597098e-12 1 PARP1|PARP_CLEAVED 0.0335608668955686 -0.119427494571832 0.0476423495090939 1 MYC|C-MYC 0.0150049826161844 -0.120794975315752 0.0227314288886973 1 BRCA2|BRCA2 1.88019419486415e-07 -0.124366654096653 5.96374096183473e-07 1 CCNE2|CYCLIN_E2 3.79193744108541e-05 -0.124412545519499 9.05603882988633e-05 1 GAB2|GAB2 0.0356075226258912 -0.126861260169178 0.0501967159239994 1 ETS1|ETS-1 0.0219614960286864 -0.133059680451572 0.0318441692415953 1 WWTR1|TAZ 3.47904526415154e-08 -0.135948043212131 1.23902840109257e-07 1 NRAS|N-RAS 1.57719801107873e-09 -0.136379533765347 6.5341060458976e-09 1 ARID1A|ARID1A 0.000117642678542441 -0.136457252591993 0.000252475336373623 1 CCND1|CYCLIN_D1 1.59796966127717e-05 -0.136469250225304 4.10617520556032e-05 1 DVL3|DVL3 1.59421398399508e-06 -0.1424459141309 4.49479776043057e-06 1 ERRFI1|MIG-6 2.71518619190146e-14 -0.143405470412052 2.29659498731665e-13 1 CHEK2|CHK2 0.000487605591667888 -0.14747515793853 0.000951768606813281 1 COL6A1|COLLAGEN_VI 5.745798428792e-05 -0.148614870405645 0.000134068630005147 1 PIK3CA |PI3K-P110-ALPHA 6.26560262386829e-06 -0.152317650796401 1.65184069174709e-05 1 GATA3|GATA3 5.19575516503381e-06 -0.153439223199121 1.40631773133582e-05 1 MS4A1|CD20 1.20601925101982e-10 -0.155129503574121 5.97126604773228e-10 1 DIABLO|SMAC 0.00071802525465136 -0.158690881517668 0.00138818215899263 1 MSH2|MSH2 0.00011815348253938 -0.158859574568041 0.000252475336373623 1 NRG1|HEREGULIN 5.62568500309178e-15 -0.16112536363917 5.71007027813816e-14 1 BCL2L1|BCL-XL 1.66637061130658e-08 -0.163230446967426 6.1504224380952e-08 1 CDH3|P-CADHERIN 1.93357026656252e-10 -0.166956275788098 9.34558962171885e-10 1 NOTCH1|NOTCH1 1.91204245505805e-12 -0.168419447268518 1.25207941411866e-11 1 BAX|BAX 6.88921311446814e-05 -0.17316944912701 0.000157135984521015 1 EIF4G1|EIF4G 0.0013083691017662 -0.175294989658097 0.00243668740971136 1 PECAM1|CD31 1.27485572596409e-14 -0.180003322117727 1.12519874943787e-13 1 PEA15|PEA15_PS116 0.00583132411708934 -0.180480816955593 0.009546441901364 1 CDH2|N-CADHERIN 5.3319969054995e-06 -0.182560671261621 1.42420443660052e-05 1 MSH6|MSH6 0.00195706935642285 -0.1870228702137 0.00354718820851642 1 FASN|FASN 0.0120627631160071 -0.190017816416825 0.0188100858846974 1 YWHAZ|14-3-3_ZETA 1.15295276553753e-07 -0.193244456434444 3.83687559678883e-07 1 RAD51|RAD51 7.27752136716456e-16 -0.19611689045288 8.20742687519114e-15 1 ERBB3|HER3 2.83665833548084e-05 -0.197196895224977 6.8552576440787e-05 1 PRDX1|PRDX1 8.32375648815986e-09 -0.199780703113085 3.18815578697444e-08 1 ASNS|ASNS 0.0024888288939424 -0.200321198819381 0.00443186197780971 1 CHEK2|CHK2_PT68 6.13541441899967e-12 -0.215093818252141 3.89215352205292e-11 1 STMN1|STATHMIN 1.94179599708943e-21 -0.221016430603802 2.81560419577967e-20 1 GAPDH|GAPDH 0.0211627639976275 -0.227647924508875 0.0311307325472347 1 SLC1A5|SLC1A5 0.00280224461900836 -0.245976345680607 0.00490392808326463 1 FOXM1|FOXM1 1.53711780427977e-07 -0.248350023267733 5.03282119788376e-07 1 HSPA1A|HSP70 0.000319445678022221 -0.249911687149467 0.000648474726385109 1 IGFBP2|IGFBP2 0.0246111848632884 -0.270158286782443 0.0354331243067202 1 SQSTM1|P62-LCK-LIGAND 5.5956843737506e-07 -0.280507328932221 1.64626656213242e-06 1 BCL2L11|BIM 5.06683604530886e-11 -0.298712582934869 2.77991274918297e-10 1 PCNA|PCNA 1.76470732808217e-15 -0.304027676608509 1.88545046105621e-14 1 SERPINE1|PAI-1 7.37580433736678e-08 -0.313553366048983 2.53777674658552e-07 1 G6PD|G6PD 9.71393188220173e-11 -0.315502896728017 4.92982043021738e-10 1 FN1|FIBRONECTIN 7.28345266715153e-10 -0.353057533990079 3.14583168389736e-09 1 TFRC|TFRC 2.26606880787171e-05 -0.414734237079351 5.54231286744527e-05 1 CASP7|CASPASE-7_CLEAVEDD198 6.33444318875995e-05 -0.424108337573173 0.000146124087195258 1 TP53|P53 2.64408912107279e-13 -0.458657640633287 1.91696461277777e-12 1 CCNE1|CYCLIN_E1 1.03331486553222e-09 -0.477697079441668 4.37006078548001e-09 1 CCNB1|CYCLIN_B1 3.0867516700865e-10 -0.640861061674735 1.42411497506264e-09 1 GAPDH|GAPDH 1.29664808959446e-21 0.900368277760914 5.26439124375351e-20 2 PEA15|PEA15_PS116 1.58090740766843e-30 0.731238666603939 1.60462101878346e-28 2 EEF2|EEF2 2.38400211235742e-28 0.724792603245357 1.61317476269519e-26 2 MYH11|MYH11 0.00128846051183842 0.713866139445117 0.0025642890578745 2 ETS1|ETS-1 8.52461492896091e-34 0.624198627345699 1.73049683057906e-31 2 BAX|BAX 3.28406247323263e-20 0.46285475709988 9.52378117237463e-19 2 CASP7|CASPASE-7_CLEAVEDD198 0.00037401291212546 0.446779309071519 0.000843606901794093 2 TGM2|TRANSGLUTAMINASE 3.19202144938361e-06 0.430084604573349 1.07996725704145e-05 2 ANXA1|ANNEXIN-1 9.21121855198625e-05 0.418811519120366 0.00023669333747509 2 CAV1|CAVEOLIN-1 0.017517801923307 0.38503291580011 0.0293893701688539 2 GATA3|GATA3 1.19702580983753e-20 0.357420397400068 4.04993732328364e-19 2 G6PD|G6PD 2.49329983912738e-06 0.346301796682522 8.98662478070907e-06 2 MAPK1|ERK2 1.56245985836268e-19 0.343164762564185 3.9647418905953e-18 2 DIABLO|SMAC 1.02418921868052e-09 0.308820539321624 5.33103618954219e-09 2 YWHAZ|14-3-3_ZETA 1.41604574568387e-12 0.298983847272516 1.1498291454953e-11 2 TFRC|TFRC 0.00360178624004003 0.298095575130836 0.00664693278843751 2 LCK|LCK 1.12425613602114e-12 0.295440492662489 9.51831293212595e-12 2 CDH2|N-CADHERIN 2.41125114279178e-15 0.289028720588452 3.05927488741707e-14 2 BCL2L1|BCL-XL 2.60927997359121e-23 0.288825226754503 1.32420958659754e-21 2 MYH9|MYOSIN-IIA 4.63137400824046e-13 0.276370379955753 4.70084461836407e-12 2 PARK7|DJ-1 8.99036271834681e-15 0.272939829063314 1.07355507754377e-13 2 COL6A1|COLLAGEN_VI 4.62366610048771e-09 0.249333707578209 2.34651054599751e-08 2 FN1|FIBRONECTIN 0.000219657310590798 0.247311539349984 0.000530838500594428 2 SERPINE1|PAI-1 0.00092715051376702 0.241214953738233 0.00190112681105763 2 CCND1|CYCLIN_D1 1.12531778507893e-12 0.228972664676634 9.51831293212595e-12 2 RAB11A RAB11B|RAB11 3.53429311642986e-13 0.220442505134041 3.77611317176453e-12 2 PRDX1|PRDX1 1.19929810117675e-07 0.21706865211744 4.8691502907776e-07 2 RAD50|RAD50 1.27223331794505e-05 0.21478273261622 3.85467706780366e-05 2 PEA15|PEA15 7.74978580751274e-09 0.209201328848817 3.74572980696449e-08 2 ITGA2|CD49B 0.000308294258099845 0.208369177378972 0.000719353268899638 2 MS4A1|CD20 2.94009340295209e-16 0.203734303351482 4.80259778020647e-15 2 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.0480567992823756 0.201871969006141 0.0717318401053106 2 TIGAR|TIGAR 2.67190790213547e-10 0.195878453511262 1.59528618862794e-09 2 NF2|NF2 1.58441865001939e-05 0.188633725856099 4.72995567579318e-05 2 SLC1A5|SLC1A5 0.0396670823477078 0.184241971236317 0.0605444941096593 2 HSPA1A|HSP70 0.0275079479448215 0.176331562260635 0.0439693971086517 2 YBX1|YB-1 9.9415226892374e-08 0.169174606427836 4.11863082839835e-07 2 MYH9|MYOSIN-IIA_PS1943 1.90456379520775e-05 0.163510593845298 5.55359561885156e-05 2 ANXA7|ANNEXIN_VII 2.14185171786978e-07 0.15240188237068 8.52540977897187e-07 2 BID|BID 3.00656434779015e-10 0.150730391474052 1.74380732171829e-09 2 STK11|LKB1 8.78035923154223e-12 0.149057273234313 6.36576044286812e-11 2 RB1|RB 1.98375017450954e-05 0.145506008084881 5.67184909049911e-05 2 ERCC1|ERCC1 7.67427782179616e-05 0.13447631084333 0.000199727999721105 2 ERRFI1|MIG-6 2.46510251726015e-10 0.122912577871272 1.5164115484964e-09 2 SMAD3|SMAD3 0.000182067374868692 0.109411026182696 0.000450727769492006 2 RAD51|RAD51 2.44638974051714e-05 0.108364026972293 6.80297420993123e-05 2 WWTR1|TAZ 2.23900379913891e-05 0.103982293278561 6.31274682257221e-05 2 EGFR|EGFR 0.00141717862581221 0.102752947538769 0.00276622366384499 2 PCNA|PCNA 0.0262551285906711 0.0968154717255505 0.0422999293960812 2 CDKN1A|P21 0.0100423841645081 0.0960307218642516 0.0176178848758596 2 YWHAE|14-3-3_EPSILON 6.88669184222534e-06 0.0893637012399571 2.15076683687961e-05 2 ACVRL1|ACVRL1 0.000658214841349267 0.0872191687430928 0.0013918501332698 2 CDH3|P-CADHERIN 0.00237960186929763 0.0852672021831144 0.00455716207044735 2 XBP1|XBP1 0.0146473324711594 0.0714955636911975 0.0254137477918407 2 YAP1|YAP 0.0225925592722327 0.0665957051541095 0.0366903162581059 2 PDK1|PDK1 0.00329288482958513 0.0644428985486813 0.00618940389264612 2 STMN1|STATHMIN 0.0313368200118741 0.0595910747266306 0.0489336497108496 2 GSK3A GSK3B|GSK3-ALPHA-BETA 0.0210934272560277 0.0581765373962529 0.0349857427332035 2 BECN1|BECLIN 0.00267585322955413 0.0573092289266515 0.00507661874392045 2 EGFR|EGFR_PY1173 0.000522861561308983 0.0559930467707041 0.001129158478146 2 YWHAB|14-3-3_BETA 0.0100673627862055 0.0475152113059282 0.0176178848758596 2 MET|C-MET_PY1235 0.0161737621688906 0.0376595570750035 0.0278243535617355 2 CDKN1B|P27_PT157 0.0399659875482316 0.0223874918755574 0.0605454885991867 2 RICTOR|RICTOR_PT1135 0.0219739807242104 -0.0418312121983398 0.0359735329597961 2 ARAF|A-RAF_PS299 0.0288572799571044 -0.0507914939604993 0.0455981142154752 2 RPS6KB1|P70S6K 0.0332077790448516 -0.0738147403666905 0.0514593827946937 2 PRKCD|PKC-DELTA_PS664 0.000508156822068418 -0.0817193708092206 0.0011092025255902 2 TSC1|TSC1 0.00638015253147884 -0.0879108901949428 0.0115640264633054 2 CHEK1|CHK1_PS345 0.00110546814436108 -0.0888502765787314 0.00224410033305299 2 FOXO3|FOXO3A_PS318_S321 2.70078405114012e-05 -0.0977013680342572 7.40890759974925e-05 2 GATA6|GATA6 0.000589149484974693 -0.0990016949147967 0.00125891942578803 2 SMAD1|SMAD1 0.000441752311783298 -0.111099963291173 0.000985447464747357 2 RPTOR|RAPTOR 6.39756989531777e-05 -0.118252633282515 0.000170882459045988 2 PREX1|PREX1 0.0211982579122366 -0.126545613548228 0.0349857427332035 2 CHEK2|CHK2_PT68 7.22554197702501e-05 -0.127358119574864 0.000190491561212478 2 MAPK8|JNK_PT183_PY185 6.33463239986662e-07 -0.127594938554134 2.42628373051495e-06 2 XRCC5|KU80 0.00359363273336443 -0.144275520241682 0.00664693278843751 2 EEF2K|EEF2K 0.0351966857278746 -0.149357952065788 0.0541282363845344 2 RAF1|C-RAF 1.29565011642203e-08 -0.151600633692678 5.88597123672207e-08 2 CHEK2|CHK2 0.000353168843065621 -0.157607212001298 0.00080554241732945 2 PRKCA |PKC-ALPHA_PS657 0.0170484426530008 -0.163763868010391 0.0290826374668837 2 RPS6KA1|P90RSK_PT359_S363 2.88973363409332e-06 -0.163986392093382 9.96600677165912e-06 2 ESR1|ER-ALPHA_PS118 0.00940519395245227 -0.16581574541498 0.016747845371472 2 BAP1|BAP1-C-4 0.000294028799209481 -0.166118407162715 0.000694044723715403 2 RPS6|S6 0.00126455543972356 -0.166176282757221 0.00254163123033547 2 RPS6KB1|P70S6K_PT389 5.03226882443714e-08 -0.170330167809569 2.12823035700154e-07 2 BRD4|BRD4 0.0016979983841849 -0.176972084375046 0.00328279687609081 2 EIF4G1|EIF4G 0.00441384280478056 -0.186151917738093 0.00807216296730138 2 BAD|BAD_PS112 1.24091756938422e-08 -0.19426125192322 5.85828526941853e-08 2 MTOR|MTOR 4.78385282764176e-10 -0.202580342304726 2.69756145558688e-09 2 SHC1|SHC_PY317 1.70679507324516e-12 -0.204183760987118 1.29296624471531e-11 2 PTEN|PTEN 0.00718239308938063 -0.20557494100128 0.0129028831605687 2 RICTOR|RICTOR 0.0464908875471451 -0.207826655974645 0.0699085197931145 2 PIK3CA |PI3K-P110-ALPHA 1.71970879838982e-12 -0.210457732798455 1.29296624471531e-11 2 AKT1S1|PRAS40_PT246 1.58147110055942e-13 -0.218767790115785 1.78354796340868e-12 2 JUN|C-JUN_PS73 1.24613788106021e-15 -0.219907576920955 1.68643993236815e-14 2 AKT1 AKT2 AKT3|AKT 5.0764137273513e-06 -0.220539262912767 1.63573331214653e-05 2 AR|AR 0.000800046471977547 -0.224428890393657 0.00167432405991177 2 SRC|SRC_PY416 4.1466587310543e-08 -0.228197939745845 1.79100366468941e-07 2 ACACA|ACC1 0.000905337599532875 -0.229279214164231 0.00187534217046096 2 EGFR|EGFR_PY1068 2.89652413560536e-06 -0.232493693742692 9.96600677165912e-06 2 STAT3|STAT3_PY705 1.08344143474615e-05 -0.235305548928533 3.33240320081013e-05 2 CCNB1|CYCLIN_B1 0.0289761415457946 -0.236011735899702 0.0455981142154752 2 FOXM1|FOXM1 4.92499139878284e-07 -0.240928431046591 1.92264087298638e-06 2 MTOR|MTOR_PS2448 2.34542721376616e-17 -0.24477278785542 4.32837931267755e-16 2 SYK|SYK 0.00132696976853703 -0.245075023233825 0.00261528993216521 2 RBM15|RBM15 0.000222998146211643 -0.247293050665363 0.000532572043305453 2 MAP2K1|MEK1_PS217_S221 1.43793689327535e-08 -0.247965751640626 6.34567802901948e-08 2 ASNS|ASNS 0.000203338270494557 -0.258596485136637 0.000497321312173435 2 AKT1 AKT2 AKT3|AKT_PT308 0.0172601507151379 -0.264253502718582 0.0291984216264416 2 FASN|FASN 0.000465453613102305 -0.265262764957973 0.00102703351586704 2 MSH6|MSH6 1.91503297201778e-05 -0.278558436476178 5.55359561885156e-05 2 MSH2|MSH2 8.00743103563029e-13 -0.294255444109862 7.38867500105886e-12 2 TP53|P53 8.54872930875462e-07 -0.31743950086467 3.21368898088368e-06 2 TSC2|TUBERIN_PT1462 3.86623851522466e-16 -0.320847015369338 5.60604584707576e-15 2 PDCD4|PDCD4 0.000157922235331103 -0.324051755254939 0.000395780416940912 2 PRKAA1|AMPK_PT172 0.000340498490764907 -0.335395305719279 0.000785468109378138 2 CDK1|CDK1_PY15 3.32494875783056e-18 -0.336272422732209 6.74964597839604e-17 2 NDRG1|NDRG1_PT346 0.000124664424999061 -0.356270839518196 0.000316335978435117 2 TSC2|TUBERIN 7.81282420734082e-10 -0.362607777453357 4.17369293181628e-09 2 EIF4EBP1|4E-BP1_PT37_T46 3.63685877104494e-06 -0.367329490048072 1.21029890249528e-05 2 RPS6|S6_PS240_S244 9.58424388937989e-07 -0.37400570190174 3.53745729008021e-06 2 PRKCB|PKC-PAN_BETAII_PS660 7.09072746915297e-13 -0.38979988072569 6.85436988684787e-12 2 ACACA ACACB|ACC_PS79 5.83284600717818e-10 -0.40724255972893 3.20018307961397e-09 2 MAPK14|P38_PT180_Y182 4.27588530388964e-06 -0.407764753667715 1.40000760756387e-05 2 STAT5A|STAT5-ALPHA 2.52333799261289e-06 -0.411223163707625 8.98662478070907e-06 2 RB1|RB_PS807_S811 5.09545128830369e-09 -0.44384110388202 2.5228697842089e-08 2 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 1.30477194902706e-08 -0.457812431171234 5.88597123672207e-08 2 GSK3A GSK3B|GSK3_PS9 1.32049631817267e-10 -0.481910396974906 8.64712105125974e-10 2 AKT1 AKT2 AKT3|AKT_PS473 5.59438085030215e-05 -0.49210030332347 0.000151421241681512 2 MAPK1 MAPK3|MAPK_PT202_Y204 2.32244246062804e-10 -0.498034656946667 1.47329943596091e-09 2 RPS6|S6_PS235_S236 5.9686165531987e-11 -0.510463231520878 4.03876386766445e-10 2 ATM|ATM 1.0264120247497e-11 -0.581810041652681 7.1848841732479e-11 2 SRC|SRC_PY527 3.07555522870365e-16 -0.641003698740323 4.80259778020647e-15 2 VHL|VHL 5.31487300559331e-06 -0.645758729304517 1.68581128146163e-05 2 NFKB1|NF-KB-P65_PS536 2.59097449881742e-19 -0.706961244339602 5.8440869251104e-18 2 CCNB1|CYCLIN_B1 3.73765720565375e-18 0.868709426415951 9.48430515934639e-17 3 TP53|P53 1.47193173421468e-17 0.762115625899732 3.32002380050644e-16 3 CCNE1|CYCLIN_E1 1.2440671753921e-11 0.587382534747291 9.7132937155614e-11 3 FOXM1|FOXM1 3.43112149395328e-20 0.477924380547512 9.95025233246451e-19 3 MSH6|MSH6 7.59616146267827e-13 0.451708749565855 8.11589882591415e-12 3 ASNS|ASNS 5.50095682488725e-10 0.446237977694601 2.79173558863028e-09 3 FASN|FASN 3.83633935544635e-09 0.442158892170429 1.6569721045864e-08 3 MSH2|MSH2 2.06757908352519e-23 0.438172688599972 1.04929638488903e-21 3 VHL|VHL 0.0010816128775651 0.427887886638403 0.00231123593837595 3 ATM|ATM 4.99256061855505e-06 0.381825587477269 1.51267135159205e-05 3 EIF4G1|EIF4G 3.08741855086873e-10 0.352550769496781 1.74096101618431e-09 3 PIK3CA |PI3K-P110-ALPHA 1.33242508852439e-25 0.352376322859275 9.01607643234837e-24 3 IGFBP2|IGFBP2 0.00448029275860511 0.346404062349709 0.00834403146786089 3 CHEK2|CHK2_PT68 9.16302775029894e-16 0.337073794243801 1.24006308887379e-14 3 CHEK2|CHK2 1.36334100425239e-10 0.297543378466599 8.38661284434046e-10 3 SQSTM1|P62-LCK-LIGAND 5.61457563655267e-06 0.294186866500206 1.67611596208852e-05 3 BCL2L11|BIM 5.51390533349827e-08 0.281968446513461 2.19475055431402e-07 3 PTEN|PTEN 0.000601082410823753 0.252109988412608 0.0013710081954744 3 BAP1|BAP1-C-4 2.20312766253988e-10 0.250020908660994 1.27781404427313e-09 3 PREX1|PREX1 8.75204962183261e-06 0.233076947163234 2.53809439033146e-05 3 BRD4|BRD4 1.91843355565911e-05 0.222256909103318 5.33482207943561e-05 3 CDK1|CDK1_PY15 5.88335498311882e-08 0.216189662332076 2.2534359652323e-07 3 PCNA|PCNA 3.37020650045878e-08 0.214780248084725 1.36830383918626e-07 3 GAB2|GAB2 0.00328162193764322 0.212693312562924 0.00634446907944356 3 ACACA|ACC1 0.00359803228714113 0.207251080269421 0.00676296809527453 3 RPS6KB1|P70S6K_PT389 4.11006396607086e-07 0.198334842699129 1.46375962300418e-06 3 GATA6|GATA6 5.65573326609936e-11 0.193170856301408 3.82704617672723e-10 3 ERBB3|HER3 0.000345718453353046 0.19138802412668 0.000816056349193818 3 ARID1A|ARID1A 5.52246791090832e-07 0.183284538656863 1.93286376881791e-06 3 RPS6|S6 0.000184947035604451 0.182362038886757 0.000463509237379056 3 STAT5A|STAT5-ALPHA 0.0169120608634884 0.177654799600334 0.0281405602892471 3 NOTCH1|NOTCH1 9.15930449859745e-10 0.174748427935314 4.32404375166345e-09 3 STMN1|STATHMIN 9.68233484840752e-11 0.166335757697021 6.14223116945852e-10 3 PARP1|PARP_CLEAVED 0.00153426450301878 0.160867249549554 0.00317811932768176 3 BRCA2|BRCA2 3.91299486329796e-11 0.159453185885118 2.73909640430857e-10 3 NRG1|HEREGULIN 3.85449681540399e-10 0.146317485465496 2.11476446899192e-09 3 NRAS|N-RAS 7.44068829118131e-12 0.144236529048154 6.56721618743394e-11 3 CCNE2|CYCLIN_E2 1.18333693645478e-05 0.138512992523357 3.38334363521578e-05 3 SRSF1|SF2 1.56639094352529e-12 0.137638068461709 1.58988680767817e-11 3 PECAM1|CD31 6.6966986856611e-08 0.134145061737231 2.51746265405408e-07 3 RBM15|RBM15 0.0306437193195845 0.131814075475919 0.0471263259233004 3 KIT|C-KIT 0.0119232458619549 0.125149652761287 0.0201701575831404 3 SRC|SRC 0.00217000646346386 0.123912060977714 0.00431873835375651 3 FN1|FIBRONECTIN 0.0485885004557981 0.121925847243669 0.0689752838638253 3 XRCC5|KU80 0.00687154976377645 0.118167947375823 0.0121297791482315 3 DVL3|DVL3 0.000884333081519376 0.117864762107102 0.00193031844675735 3 RAF1|C-RAF 4.88179699702598e-05 0.116109777652728 0.000128701920830685 3 TSC2|TUBERIN 0.030580630523658 0.112745963831942 0.0471263259233004 3 MTOR|MTOR 0.000198897124112517 0.111641490497917 0.000480668049938583 3 RPTOR|RAPTOR 0.000517858843481751 0.109858954213141 0.00119460619575904 3 SCD|SCD 8.76834887330402e-08 0.108285303037764 3.23631785687403e-07 3 EIF4EBP1|4E-BP1 0.0462982300663194 0.103686508111893 0.0661869063624144 3 AXL|AXL 0.0114786786304583 0.100849494230015 0.0195812753107818 3 MYC|C-MYC 0.0253506074948326 0.100095501127157 0.0402044790738361 3 MRE11A|MRE11 7.88301086026723e-11 0.0966012710380442 5.16210066011048e-10 3 BAK1|BAK 0.0353381843488699 0.0956957766565155 0.0523624191446758 3 DIRAS3|ARHI 0.000814708472451894 0.0951596301187595 0.00179767195551885 3 RAD51|RAD51 6.59289531289068e-05 0.0951506161686014 0.000171584326732924 3 XRCC1|XRCC1 0.00348451609484237 0.0900914994364668 0.00665483316714328 3 CDH3|P-CADHERIN 0.00151023206083393 0.0876041346193028 0.00316058874586895 3 MAPK14|P38_MAPK 0.012115238141793 0.078084023962351 0.0203255648163965 3 FOXO3|FOXO3A 7.93760040605272e-05 0.0777847735108921 0.000203966187649203 3 YWHAB|14-3-3_BETA 4.75495029636278e-05 0.0700116135101347 0.000127007225021269 3 EIF4EBP1|4E-BP1_PT70 0.00215988384996887 0.069197769472708 0.00431873835375651 3 SMAD1|SMAD1 0.030956557906822 0.0679888828014473 0.0472494831209388 3 ERBB3|HER3_PY1289 7.05653616389284e-06 0.0677708550077636 2.07605339314528e-05 3 SHC1|SHC_PY317 0.0193838844435784 0.0657505960294326 0.031991288959727 3 JUN|C-JUN_PS73 0.0325686402530353 0.062730813803555 0.0486134850835747 3 ARAF|A-RAF_PS299 0.0066496887059743 0.0582312893171557 0.011841112344849 3 CHEK1|CHK1 0.0296803778200463 0.0572732458935569 0.0463470515189954 3 MET|C-MET_PY1235 0.000116050957219917 0.0501264632252437 0.000294479303945539 3 SMAD4|SMAD4 0.0462528830298087 0.0441032964207255 0.0661869063624144 3 BECN1|BECLIN 0.00959285258525104 0.0440741276022443 0.0165029582610675 3 EGFR|EGFR_PY1173 0.00741014796384663 0.0379748354973572 0.0129677589367316 3 CDKN1B|P27_PT157 0.00286399418008817 0.03209796724604 0.00559029633228749 3 RAF1|C-RAF_PS338 0.00579445821012101 -0.0396037159860782 0.0105970722221132 3 CHEK1|CHK1_PS345 0.0252907088676538 -0.0588465579480257 0.0402044790738361 3 RB1|RB 0.0419765775500677 -0.0606209291705773 0.0613039226090917 3 FOXO3|FOXO3A_PS318_S321 0.00096685905928253 -0.0745554843965702 0.00208800413866334 3 ANXA7|ANNEXIN_VII 0.00201213738092725 -0.0788960205582477 0.00408463888328232 3 CCND1|CYCLIN_D1 0.00915221322358773 -0.0789404636322285 0.0158794810631479 3 STK11|LKB1 3.28742103219101e-05 -0.0806779853989577 8.89795292713033e-05 3 COL6A1|COLLAGEN_VI 0.0220585194876347 -0.0859497450918873 0.0355387258411892 3 RICTOR|RICTOR_PT1135 3.81134966617481e-06 -0.0861663870980291 1.19031381882075e-05 3 YWHAZ|14-3-3_ZETA 0.0211502499901896 -0.0879174067435042 0.0346250060323265 3 CDH2|N-CADHERIN 0.0261068824299993 -0.0892711019921705 0.0410829235138749 3 MAPK9|JNK2 0.00350771994524301 -0.105285290745085 0.00665483316714328 3 BCL2L1|BCL-XL 0.000632796027951417 -0.108552849393409 0.00142730659637931 3 BAD|BAD_PS112 0.0022189147508122 -0.114981042826261 0.00437320091664929 3 RAB11A RAB11B|RAB11 2.57516839914422e-06 -0.120376656594769 8.16811226603557e-06 3 SRC|SRC_PY416 0.0064078675301623 -0.121357948475441 0.0116142598984192 3 MYH9|MYOSIN-IIA_PS1943 0.0017185575035935 -0.123108029271727 0.00352391084070182 3 YBX1|YB-1 1.25899110692268e-05 -0.124749118458514 3.54965548201811e-05 3 RPS6KA1|P90RSK_PT359_S363 0.000191306058907654 -0.12965213904384 0.000467893132027154 3 DIABLO|SMAC 0.00664060894129064 -0.132025807555185 0.011841112344849 3 INPP4B|INPP4B 0.0215525671996193 -0.134148657091048 0.0350013691321817 3 PGR|PR 0.00115589400272431 -0.135666683213174 0.00244423419326078 3 EGFR|EGFR 1.87645642335278e-06 -0.142462176405857 6.1438815151712e-06 3 PIK3R1 PIK3R2|PI3K-P85 0.000383421874306922 -0.144591909782676 0.000894651040049485 3 PRKCA |PKC-ALPHA 0.045801501454541 -0.148207375118002 0.0661869063624144 3 AKT1S1|PRAS40_PT246 7.98596808248088e-07 -0.154117922853858 2.74771444193834e-06 3 PDK1|PDK1_PS241 4.36900662580755e-06 -0.155802470003252 1.34380052278626e-05 3 TIGAR|TIGAR 3.08692901653587e-08 -0.157617814621048 1.27887059256486e-07 3 RAD50|RAD50 0.000188449786352303 -0.16015894751542 0.000466528129628262 3 PEA15|PEA15 1.60685474369166e-06 -0.170036354520821 5.34740185195749e-06 3 KDR|VEGFR2 0.000763289339634806 -0.17350751598453 0.00170272237303149 3 NDRG1|NDRG1_PT346 0.0403466125269002 -0.177654813213043 0.0593504517605851 3 ITGA2|CD49B 0.000205275182537818 -0.179406193574713 0.000490245435943259 3 SRC|SRC_PY527 0.0315729783119637 -0.180688753116471 0.0478307059502137 3 GATA3|GATA3 5.64409819185363e-08 -0.183253228283911 2.20336910181978e-07 3 PARK7|DJ-1 1.20713429939717e-09 -0.18566137481574 5.56927869949149e-09 3 MYH9|MYOSIN-IIA 1.44674958717711e-07 -0.186047356087733 5.24446725351702e-07 3 YBX1|YB-1_PS102 4.17774208595133e-10 -0.200750521225392 2.23179379854768e-09 3 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.0322917949522653 -0.21397435970802 0.0485572916689619 3 RPS6|S6_PS235_S236 0.00493765555096909 -0.22577953757687 0.00911221888042477 3 LCK|LCK 7.07071746898389e-10 -0.238451003459963 3.41751344334221e-09 3 TSC2|TUBERIN_PT1462 3.11673634452415e-09 -0.239707242299867 1.37542929986609e-08 3 PRKCB|PKC-PAN_BETAII_PS660 1.5989465703722e-06 -0.250020810449705 5.34740185195749e-06 3 BAX|BAX 4.75633255692663e-10 -0.263032913475178 2.47573207450284e-09 3 PRKAA1|AMPK_ALPHA 2.51366860478668e-15 -0.274699978123996 3.1892170423231e-14 3 NF2|NF2 6.14595972838542e-12 -0.284862619531787 5.67104465846473e-11 3 MAPK1|ERK2 3.52912348288108e-22 -0.337097265148019 1.43282413404972e-20 3 MAP2K1|MEK1_PS217_S221 3.94611053777996e-16 -0.356027223237873 6.16200337822563e-15 3 CDH1|E-CADHERIN 2.34087671367654e-05 -0.393074114307408 6.42159422805862e-05 3 ESR1|ER-ALPHA_PS118 1.53684485565141e-11 -0.395123029877058 1.1554796507305e-10 3 ETS1|ETS-1 8.48220571437834e-16 -0.455943728436467 1.22991982858486e-14 3 TGM2|TRANSGLUTAMINASE 6.73665501413967e-10 -0.460329557339253 3.33546577529354e-09 3 YAP1|YAP_PS127 1.19688083489479e-13 -0.50008334137067 1.34981560824246e-12 3 PEA15|PEA15_PS116 1.87889752498247e-17 -0.509344103818769 3.81416197571441e-16 3 CTNNB1|BETA-CATENIN 6.86211937982907e-09 -0.522360433360329 2.90210465438604e-08 3 GSK3A GSK3B|GSK3_PS9 2.77925128017508e-12 -0.526772545362733 2.68660957083591e-11 3 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 3.56780177106829e-11 -0.541084377162377 2.58665628402451e-10 3 CAV1|CAVEOLIN-1 2.54616984961302e-06 -0.55718109929985 8.16811226603557e-06 3 EEF2|EEF2 3.08134789227142e-20 -0.586426457149699 9.95025233246451e-19 3 GAPDH|GAPDH 2.03711987327334e-09 -0.621687578269059 9.18967409498862e-09 3 MAPK14|P38_PT180_Y182 6.82136523245534e-15 -0.634202991356772 8.14551260110843e-14 3 MAPK1 MAPK3|MAPK_PT202_Y204 8.59611766485294e-17 -0.645994338056189 1.45417657163762e-15 3 ANXA1|ANNEXIN-1 9.0776818302557e-12 -0.672559717959931 7.37107764616763e-11 3 PDCD4|PDCD4 2.95546206805326e-17 -0.681334217801233 5.45417090740738e-16 3 ESR1|ER-ALPHA 1.75131029101314e-10 -1.01425915740577 1.04563526198726e-09 3 AKT1 AKT2 AKT3|AKT_PT308 1.07088905219095e-29 -1.2426385789886 2.17390477594763e-27 3 MYH11|MYH11 8.20375307336579e-12 -1.30054867552872 6.93900780788857e-11 3 AKT1 AKT2 AKT3|AKT_PS473 2.48228737318785e-26 -1.30563535223926 2.51952168378567e-24 3