rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(1), CDKN2A(1), E2F1(1), MYC(2), PIK3CA(22), PIK3R1(8), POLR1A(2), POLR1B(1), RAC1(1), RB1(6), TBX2(1), TP53(55) 1719962 101 55 80 1 22 11 17 25 24 2 1.25e-10 <1.00e-15 <9.37e-14 2 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(2), ATM(3), BCL2L1(1), CASP7(1), EIF2S1(1), PXN(1), STAT1(1), TP53(55) 2302234 65 53 53 2 16 6 14 13 15 1 4.31e-06 <1.00e-15 <9.37e-14 3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CCND1(1), CDKN2A(1), E2F1(1), TP53(55) 728452 58 52 46 0 15 6 12 12 12 1 8.96e-08 <1.00e-15 <9.37e-14 4 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR3(1), PIK3CA(22), PIK3R1(8), RAC1(1), WASL(1) 1132069 33 27 24 1 4 6 5 11 7 0 0.00469 <1.00e-15 <9.37e-14 5 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 GNB1(1), ITGAV(1), PIK3CA(22), PIK3R1(8), RAC1(1) 2322413 33 27 24 1 4 6 5 11 7 0 0.00295 <1.00e-15 <9.37e-14 6 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 ITGB1(1), PDK2(1), PIK3CA(22), PIK3R1(8), PTEN(15) 1630880 47 30 37 0 4 8 9 13 12 1 1.53e-05 1.44e-15 9.37e-14 7 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(2), BCL2L1(1), CASP7(1), CASP8(2), GZMB(1), MAP2K4(1), MAP3K1(1), MAPK10(1), MYC(2), TP53(55) 3179857 67 52 55 5 18 6 12 13 17 1 5.75e-05 1.55e-15 9.37e-14 8 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 GAB1(1), GCK(1), IL1R1(1), MAP2K4(1), MAP3K1(1), MAP3K4(4), MAP3K5(2), MAP3K9(1), MAPK10(1), MAPK7(1), MAPK9(1), PAPPA(1), TP53(55), ZAK(1) 4282008 72 52 60 8 18 5 16 15 17 1 0.00255 1.55e-15 9.37e-14 9 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(3), ATR(3), BRCA2(4), CHEK2(2), FANCC(1), FANCD2(1), FANCE(1), FANCF(1), FANCG(1), HUS1(1), MRE11A(1), RAD9A(1), TP53(55) 3685680 75 52 63 4 16 7 18 18 15 1 7.44e-05 2.22e-15 9.37e-14 10 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 IRS1(2), PIK3CA(22), PIK3R1(8), PTPN11(1), RASA1(1) 2121354 34 27 25 2 3 6 5 11 9 0 0.0113 2.33e-15 9.37e-14 11 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(2), ATM(3), CCND1(1), E2F1(1), RB1(6), TP53(55) 1513923 68 53 56 0 16 6 12 14 18 2 2.89e-08 2.55e-15 9.37e-14 12 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(6), PML(1), RB1(6), SIRT1(1), TP53(55) 1613841 69 52 57 0 18 6 12 14 17 2 5.58e-09 2.55e-15 9.37e-14 13 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2S1(1), INPPL1(1), PDK2(1), PIK3CA(22), PIK3R1(8), PTEN(15) 1660531 48 29 38 3 4 8 9 12 13 2 0.00224 2.66e-15 9.37e-14 14 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(3), ATR(3), CHEK2(2), EP300(1), PRKDC(2), TP53(55), WEE1(1) 3513011 67 52 55 3 15 6 13 16 16 1 3.62e-05 2.78e-15 9.37e-14 15 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(3), RB1(6), TP53(55), WEE1(1) 1464466 65 53 53 1 14 5 12 15 17 2 2.76e-06 3.00e-15 9.37e-14 16 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3E(1), CD80(2), CD86(1), HLA-DRA(1), IL2(1), ITK(1), PIK3CA(22), PIK3R1(8), PTPN11(1) 1085606 38 29 29 0 6 8 5 12 7 0 0.000115 3.44e-15 9.37e-14 17 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 E2F1(1), FBXW7(24), RB1(6) 686904 31 27 22 0 13 4 5 2 6 1 5.13e-05 3.55e-15 9.37e-14 18 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 EIF2S1(1), TP53(55) 828525 56 51 44 1 14 5 11 12 13 1 6.59e-06 3.66e-15 9.37e-14 19 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(1), ATM(3), ATR(3), CCNA1(1), CCND1(1), CDK6(1), CDKN2A(1), CDKN2B(1), E2F1(1), RB1(6), TGFB1(1), TP53(55) 2540817 75 53 63 2 18 6 14 18 17 2 5.07e-07 3.77e-15 9.37e-14 20 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4B(1), EIF4G1(1), EIF4G2(1), EIF4G3(1), PDK2(1), PIK3CA(22), PIK3R1(8), PTEN(15), TSC1(1) 2341534 51 30 41 1 4 9 10 14 13 1 7.28e-05 3.89e-15 9.37e-14 21 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 MAPK7(1), MEF2C(1), NTRK1(2), PIK3CA(22), PIK3R1(8) 1610617 34 25 25 1 5 6 6 10 7 0 0.00204 3.89e-15 9.37e-14 22 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MYC(2), SP1(1), TP53(55) 599710 58 52 46 0 15 5 11 14 12 1 6.18e-08 4.00e-15 9.37e-14 23 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IKBKB(1), JAK2(2), LIN7A(1), RB1(6), TP53(55) 1529349 65 52 53 0 15 6 12 14 16 2 2.43e-08 4.00e-15 9.37e-14 24 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 BCL2L1(1), PIK3CA(22), PIK3R1(8), RAC1(1), RALGDS(2) 1634536 34 28 25 1 5 7 5 10 7 0 0.00174 4.33e-15 9.37e-14 25 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(3), ATM(3), FHL2(1), HIF1A(1), TP53(55) 1758312 63 53 51 0 17 5 13 14 13 1 6.75e-08 4.44e-15 9.37e-14 26 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(1), ATM(3), CCNA1(1), CCNB2(1), CCNB3(1), CCND2(1), CCNE2(1), CDC6(1), CDC7(1), CDKN2A(1), CHEK2(2), DTX4(2), E2F1(1), EP300(1), HDAC2(1), HDAC6(2), HDAC8(1), MAD1L1(3), MCM2(1), MCM3(1), MCM5(1), MCM6(1), MCM7(1), PLK1(1), PRKDC(2), PTPRA(1), RB1(6), SMAD4(1), TBC1D8(1), TGFB1(1), TP53(55), WEE1(1) 9308623 99 54 87 8 19 7 20 26 24 3 3.55e-05 4.66e-15 9.37e-14 27 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(3), CCNA1(1), CCND1(1), CCND2(1), CCNE2(1), CDKN2A(1), CDKN2B(1), E2F1(1), MCM2(1), MCM3(1), MCM5(1), MCM6(1), MCM7(1), MNAT1(1), MYC(2), NACA(2), POLE(1), POLE2(1), RB1(6), RPA1(1), TNXB(3), TP53(55), WEE1(1) 6583713 88 54 76 6 20 6 21 21 17 3 5.81e-06 4.66e-15 9.37e-14 28 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), APAF1(2), ATM(3), BCL2L1(1), CASP7(1), CASP8(2), CFLAR(1), CSF2RB(1), IKBKB(1), IL1A(1), IL1B(2), IL1R1(1), IL1RAP(1), IL3RA(1), IRAK4(1), MYD88(1), NTRK1(2), PIK3CA(22), PIK3CG(2), PIK3R1(8), PPP3CB(1), PRKAR1A(1), PRKAR2A(1), TP53(55) 7085113 113 55 92 5 26 13 22 29 22 1 8.51e-09 4.77e-15 9.37e-14 29 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 ITGB1(1), KLRC3(1), PIK3CA(22), PIK3R1(8), PTPN6(1), RAC1(1) 1567278 34 28 25 1 3 6 5 12 8 0 0.00396 4.88e-15 9.37e-14 30 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 PIK3CA(22), PIK3R1(8) 1400364 30 25 21 0 3 6 4 10 7 0 0.000853 5.00e-15 9.37e-14 31 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 PIK3CA(22), PTEN(15) 1728211 37 25 27 0 4 7 8 12 5 1 3.54e-05 5.11e-15 9.37e-14 32 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(1), ATM(3), CHEK2(2), MRE11A(1), TP53(55), TP73(1) 2501513 63 52 51 1 14 5 13 16 14 1 2.65e-06 5.22e-15 9.37e-14 33 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 MYC(2), POLR2A(2), RB1(6), TEP1(1), TNKS(1), TP53(55) 2390234 67 53 55 2 15 6 11 17 16 2 9.99e-07 5.55e-15 9.37e-14 34 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP3K1(1), PIK3CA(22), PIK3R1(8), RB1(6), SP1(1) 1627121 38 29 29 1 3 6 4 12 12 1 0.00224 5.66e-15 9.37e-14 35 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 CAMK2B(1), CAMK2D(1), CAMK2G(1), GNAS(2), PIK3CA(22), PIK3R1(8), PRKAR1A(1), PRKAR2A(1), RAC1(1), RPS6KA5(1) 2499430 39 28 30 1 6 8 6 12 7 0 0.000730 5.66e-15 9.37e-14 36 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(3), ATR(3), CHEK2(2), TP53(55) 1333162 63 52 51 2 15 5 13 15 14 1 8.60e-05 5.77e-15 9.37e-14 37 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(2), ATM(3), ATR(3), BAI1(1), CASP8(2), CCNB2(1), CCNB3(1), CCND1(1), CCND2(1), CCNE2(1), CDK6(1), CDKN2A(1), CHEK2(2), EI24(1), PMAIP1(1), PTEN(15), RFWD2(2), SERPINB5(1), SIAH1(2), TP53(55), TP73(1), ZMAT3(2) 5554937 100 54 87 4 23 11 21 22 21 2 1.24e-08 6.33e-15 9.37e-14 38 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(22), PIK3R1(8) 1089705 30 25 21 1 3 6 4 10 7 0 0.00743 6.55e-15 9.37e-14 39 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 GNAQ(1), GNB1(1), PIK3C2G(2), PIK3CA(22), PIK3R1(8), PXN(1) 2333386 35 28 26 2 5 6 5 11 8 0 0.00760 6.66e-15 9.37e-14 40 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 F2(1), GNAQ(1), GNB1(1), PIK3CA(22), PIK3R1(8) 2198938 33 28 24 0 5 6 4 10 8 0 0.000513 6.66e-15 9.37e-14 41 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 KLK2(1), PIK3CA(22), PIK3R1(8) 1636116 31 26 22 1 3 6 5 10 7 0 0.00536 6.66e-15 9.37e-14 42 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(6), EP300(1), JAK3(3), PIK3CA(22), PIK3R1(8) 2380795 40 30 31 2 8 7 4 12 9 0 0.00203 6.88e-15 9.37e-14 43 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(5), CCND1(1), CD14(1), DVL1(2), GJA1(1), LBP(1), MYD88(1), PIK3CA(22), PIK3R1(8), TLR4(1) 2628083 43 27 34 2 4 9 6 14 9 1 0.00129 7.33e-15 9.37e-14 44 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4G1(1), EIF4G2(1), EIF4G3(1), IRS1(2), PABPC1(1), PDK2(1), PIK3CA(22), PIK3R1(8), PTEN(15) 2385832 52 30 42 2 4 9 11 13 14 1 0.000434 7.44e-15 9.37e-14 45 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(2), BCL2L1(1), BCL2L11(2), CASP4(1), CASP7(1), CASP8(2), GZMB(1), HELLS(1), IKBKB(1), IRF2(1), IRF6(1), LTA(1), MAP2K4(1), MAP3K1(1), MAPK10(1), MYC(2), TNFRSF21(1), TP53(55), TP73(1) 4903224 77 52 64 5 20 7 12 17 20 1 1.51e-05 7.66e-15 9.37e-14 46 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CHN1(1), MAP3K1(1), MYLK(2), NCF2(1), PIK3CA(22), PIK3R1(8), RAC1(1), TRIO(1), WASF1(1) 2966375 38 30 29 2 6 6 8 10 8 0 0.00544 7.66e-15 9.37e-14 47 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 KLK2(1), NTRK1(2), PIK3CA(22), PIK3R1(8) 1324240 33 26 24 1 4 6 6 10 7 0 0.00378 7.77e-15 9.37e-14 48 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 GNAS(2), GNB1(1), NOS3(2), PIK3CA(22), PIK3R1(8) 1555845 35 27 26 1 4 7 5 11 8 0 0.00341 7.88e-15 9.37e-14 49 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CCND1(1), CDK6(1), E2F1(1), PIK3CA(22), PIK3R1(8), RAC1(1), RB1(6) 1708265 40 30 31 1 5 7 5 11 11 1 0.000621 7.99e-15 9.37e-14 50 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 INSR(1), IRS1(2), PIK3CA(22), PIK3R1(8), PTPN11(1), RASA1(1), SLC2A4(1) 2179419 36 27 27 1 3 6 6 12 9 0 0.00200 7.99e-15 9.37e-14 51 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 IRS1(2), PIK3CA(22), PIK3R1(8) 1608595 32 26 23 2 3 6 5 10 8 0 0.0166 7.99e-15 9.37e-14 52 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 PIK3CA(22), PIK3R1(8) 1133832 30 25 21 1 3 6 4 10 7 0 0.00623 7.99e-15 9.37e-14 53 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 BCL2L1(1), CSF2RB(1), IL3RA(1), KIT(2), KITLG(1), PIK3CA(22), PIK3R1(8), PRKAR1A(1), PRKAR2A(1) 1862270 38 28 29 3 4 7 6 13 8 0 0.00904 8.10e-15 9.37e-14 54 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 JAK2(2), MAP2K4(1), MAP3K1(1), MYC(2), PIK3CA(22), PIK3R1(8), STAT1(1) 2379367 37 29 28 2 4 7 5 12 9 0 0.00801 8.22e-15 9.37e-14 55 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 JAK2(2), PIK3CA(22), PIK3R1(8), RASA1(1), STAT1(1), STAT3(2) 2536692 36 27 27 2 3 7 5 12 9 0 0.0112 8.66e-15 9.70e-14 56 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 PIK3CA(22), PIK3R1(8) 1195240 30 25 21 0 3 6 4 10 7 0 0.00124 8.99e-15 9.89e-14 57 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BFAR(2), CAD(1), CASP8(2), EPHB2(2), HSPB1(1), IL1A(1), MAP2K4(1), MAP3K1(1), MAP3K5(2), MAPK10(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(1), MET(2), NFAT5(2), PFN2(1), PTPN13(1), TNFRSF6B(2), TP53(55), TPX2(1) 6152667 83 54 71 7 21 9 18 17 17 1 6.15e-05 9.66e-15 1.04e-13 58 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 BCL2L1(1), CBL(1), CFLAR(1), E2F1(1), IL2RA(1), IRS1(2), JAK3(3), MYC(2), PIK3CA(22), PIK3R1(8), PTPN6(1) 3081366 43 30 34 1 7 8 5 13 10 0 0.000255 1.09e-14 1.16e-13 59 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), DOCK1(1), GAB1(1), HGF(1), ITGA1(2), ITGB1(1), MET(2), PIK3CA(22), PIK3R1(8), PTEN(15), PTPN11(1), PXN(1), RAP1A(1), RASA1(1), STAT3(2) 3744487 60 32 50 3 4 10 12 18 15 1 0.000227 2.20e-14 2.30e-13 60 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 NTRK1(2), PIK3CA(22) 1393523 24 20 15 0 4 5 5 10 0 0 0.000846 3.52e-14 3.61e-13 61 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 INSR(1), IRS1(2), JAK2(2), PIK3CA(22), PIK3R1(8), PTPN6(1), SLC2A4(1) 2809364 37 27 28 2 3 7 6 12 9 0 0.00647 6.26e-14 6.32e-13 62 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 IRS1(2), JAK3(3), PIK3CA(22), PIK3R1(8) 3131633 35 27 26 1 5 6 5 11 8 0 0.00187 1.02e-13 1.01e-12 63 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 MAP2K4(1), MAP3K1(1), PIK3CA(22), PIK3R1(8), RASA1(1), STAT1(1), STAT3(2) 2977254 36 28 27 3 3 6 5 11 11 0 0.0419 4.26e-12 4.16e-11 64 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 CDKN2A(1), IGFBP1(1), INPP5D(1), PIK3CA(22), PTEN(15), RPS6KA2(1), TEC(2) 3050619 43 25 33 2 6 7 9 13 7 1 0.000675 1.29e-11 1.24e-10 65 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 CBL(1), CDKN2A(1), IGFBP1(1), INPPL1(1), IRS1(2), IRS4(1), LNPEP(1), PARD3(1), PIK3CA(22), PIK3R1(8), PTEN(15), RPS6KA2(1), SLC2A4(1) 5075355 56 32 46 4 5 8 12 14 15 2 0.00282 1.47e-11 1.40e-10 66 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 BRAF(1), EIF4B(1), HIF1A(1), PIK3CA(22), PIK3CG(2), PIK3R1(8), RPS6KA2(1), RPS6KA6(2), TSC1(1), ULK1(1) 4502502 40 30 31 2 6 8 6 11 9 0 0.00280 2.78e-11 2.59e-10 67 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(2), MAP2K4(1), MAP3K1(1), PIK3CA(22), PIK3R1(8), RASA1(1), STAT1(1), STAT3(2) 3195047 38 28 29 4 3 6 7 11 11 0 0.0785 2.33e-10 2.14e-09 68 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(1), MAPK10(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(1), PIK3CA(22), PIK3R1(8) 2874808 37 28 28 4 7 6 5 10 9 0 0.0291 3.57e-10 3.23e-09 69 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(5), BRAF(1), CCL13(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(2), ITPR1(1), ITPR2(1), ITPR3(1), KCNJ9(1), MAPK10(1), PHKA2(2), PIK3CA(22), PIK3R1(8) 4555487 49 27 40 2 6 7 9 15 11 1 0.000442 1.06e-09 9.43e-09 70 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 IL13RA1(1), INPP5D(1), JAK2(2), JAK3(3), PIK3CA(22) 3139461 29 22 20 0 6 6 4 13 0 0 0.000181 2.47e-09 2.17e-08 71 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), ITGA1(2), ITGB1(1), MYLK(2), PIK3CA(22), PIK3R1(8), PXN(1) 3144978 39 28 30 4 5 8 6 13 7 0 0.0235 3.29e-09 2.86e-08 72 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(1), ANAPC1(1), ANAPC2(1), ATM(3), ATR(3), CCNA1(1), CCNB2(1), CCNB3(1), CCND1(1), CCND2(1), CCNE2(1), CDC16(1), CDC23(1), CDC27(3), CDC6(1), CDC7(1), CDK6(1), CDKN2A(1), CDKN2B(1), CHEK2(2), CREBBP(6), E2F1(1), EP300(1), HDAC2(1), MAD1L1(3), MCM2(1), MCM3(1), MCM5(1), MCM6(1), MCM7(1), PLK1(1), PRKDC(2), RB1(6), SMAD4(1), SMC1A(2), TGFB1(1), TP53(55), WEE1(1) 11444259 113 54 101 10 28 10 19 29 24 3 1.10e-05 5.87e-09 5.02e-08 73 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 BRAF(1), CREB5(1), CREBBP(6), DAG1(1), FRS2(1), GNAQ(1), MAP1B(4), MAP2K4(1), MAPK10(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(1), NTRK1(2), PIK3C2G(2), PIK3CA(22), PIK3R1(8), PTPN11(1), TH(1) 4390299 58 30 49 4 14 8 8 15 13 0 0.000306 1.50e-08 1.27e-07 74 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR3(1), DAG1(1), DGKA(2), ITGA9(2), ITPKA(1), ITPKB(2), ITPR1(1), ITPR2(1), ITPR3(1), PDE3A(1), PDE3B(1), PIK3C2G(2), PIK3CA(22), PIK3R1(8), RIPK3(1) 4118492 47 28 38 3 5 6 10 15 11 0 0.00395 1.76e-08 1.46e-07 75 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CD36(1), CPT1B(1), CREBBP(6), EP300(1), MRPL11(1), MYC(2), NCOA1(1), NCOR2(1), NR1H3(1), NRIP1(1), PIK3CA(22), PIK3R1(8), PRKAR1A(1), PRKAR2A(1), RB1(6), SP1(1) 5344190 55 34 46 5 11 8 7 14 14 1 0.00290 1.86e-08 1.53e-07 76 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(1), ARAF(1), AREG(1), BRAF(1), CAMK2B(1), CAMK2D(1), CAMK2G(1), CBL(1), CBLB(3), EGF(2), ERBB2(1), ERBB3(5), ERBB4(1), GAB1(1), KRAS(7), MAP2K4(1), MAPK10(1), MAPK9(1), MYC(2), NCK1(2), NRAS(1), NRG1(1), NRG3(1), PAK4(2), PIK3CA(22), PIK3CG(2), PIK3R1(8), PRKCG(1) 8767087 73 40 59 5 13 14 17 14 15 0 4.82e-05 3.28e-08 2.66e-07 77 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), CALR(1), CREBBP(6), ELSPBP1(1), F2(1), GATA4(1), MEF2C(1), MYH2(2), NFATC1(1), NFATC2(1), PIK3CA(22), PIK3R1(8), PPP3CB(1), PRKAR1A(1), PRKAR2A(1) 4308325 49 31 40 5 13 8 5 12 11 0 0.00553 6.95e-07 5.56e-06 78 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 CD19(1), DAG1(1), EPHB2(2), ITPKA(1), ITPKB(2), LYN(2), NFAT5(2), PIK3CA(22), PIK3R1(8) 4481453 41 26 32 3 4 7 7 15 8 0 0.00923 7.72e-07 6.10e-06 79 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF1(1), EIF2S1(1), FLT1(1), HIF1A(1), KDR(2), NOS3(2), PIK3CA(22), PIK3R1(8), PXN(1) 2895300 39 29 30 6 4 6 8 11 10 0 0.117 1.08e-06 8.43e-06 80 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR3(1), ARHGAP4(1), ARHGEF11(3), INPPL1(1), ITPR1(1), ITPR2(1), ITPR3(1), MYLK(2), PAK4(2), PIK3CA(22), PIK3CG(2), PIK3R1(8), PTEN(15), RACGAP1(1), ROCK2(4), WASF1(1), WASL(1) 5959487 67 31 57 5 10 9 12 15 19 2 0.000367 1.23e-06 9.47e-06 81 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 BCL10(1), CARD11(2), CD19(1), CR2(1), IKBKB(1), INPP5D(1), KRAS(7), LYN(2), NFAT5(2), NFATC1(1), NFATC2(1), NRAS(1), PIK3CA(22), PIK3CG(2), PIK3R1(8), PPP3CB(1), PTPN6(1), RAC1(1), RAC3(1), VAV2(1) 6318835 58 35 44 7 11 12 11 14 10 0 0.00644 5.89e-06 4.45e-05 82 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 INSR(1), MAPK7(1), MEF2C(1), NFATC1(1), NFATC2(1), PIK3CA(22), PIK3R1(8), PPP3CB(1) 2959025 36 25 27 5 6 6 5 12 7 0 0.0619 5.93e-06 4.45e-05 83 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC2(1), BTRC(1), CDC16(1), CDC23(1), CDC27(3), FBXW11(1), FBXW7(24), ITCH(2), UBA1(1), WWP1(3) 3373018 39 25 30 4 17 6 5 8 3 0 0.00540 7.48e-06 5.55e-05 84 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 KDR(2), KRAS(7), NFAT5(2), NFATC1(1), NFATC2(1), NOS3(2), NRAS(1), PIK3CA(22), PIK3CG(2), PIK3R1(8), PLA2G1B(1), PPP3CB(1), PRKCG(1), PXN(1), RAC1(1), RAC3(1) 6136071 54 35 40 7 8 11 14 13 8 0 0.0111 2.76e-05 0.000202 85 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 CD19(1), CDKN2A(1), GAB1(1), ITPR1(1), ITPR2(1), ITPR3(1), LYN(2), PIK3CA(22), PREX1(1), PTEN(15), RPS6KA2(1), TEC(2) 4680117 49 25 39 4 7 7 10 15 9 1 0.00149 4.13e-05 0.000299 86 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 BCL10(1), CARD11(2), CBL(1), CBLB(3), CD247(1), CD3E(1), CD40LG(1), IKBKB(1), IL2(1), ITK(1), KRAS(7), MAP3K8(2), NCK1(2), NFAT5(2), NFATC1(1), NFATC2(1), NRAS(1), PAK4(2), PDCD1(1), PIK3CA(22), PIK3CG(2), PIK3R1(8), PPP3CB(1), PRKCQ(1), PTPN6(1), RASGRP1(1), TEC(2), VAV2(1) 8602174 71 40 57 9 14 15 12 15 15 0 0.00302 8.14e-05 0.000583 87 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 BCL2L1(1), CBL(1), CBLB(3), CCND1(1), CCND2(1), CREBBP(6), CSF2RA(2), CSF2RB(1), EP300(1), IFNA16(1), IFNA2(2), IFNA7(1), IFNW1(2), IL12A(1), IL13RA1(1), IL2(1), IL21(1), IL2RA(1), IL3RA(1), IL5RA(1), IL6ST(1), JAK2(2), JAK3(3), LEPR(1), MYC(2), PIAS1(1), PIK3CA(22), PIK3CG(2), PIK3R1(8), PTPN11(1), PTPN6(1), SOCS2(1), SOCS5(1), SPRY1(1), STAT1(1), STAT3(2), TPO(1) 12326422 81 41 72 7 15 17 12 21 16 0 7.64e-05 0.000156 0.00110 88 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 FCER1A(1), INPP5D(1), KRAS(7), LYN(2), MAP2K4(1), MAPK10(1), MAPK9(1), NRAS(1), PIK3CA(22), PIK3CG(2), PIK3R1(8), PLA2G1B(1), PRKCE(1), RAC1(1), RAC3(1), VAV2(1) 6094953 52 33 38 7 7 10 11 13 11 0 0.0213 0.000219 0.00153 89 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(6), SP1(1) 548880 7 6 7 0 0 0 0 2 4 1 0.227 0.000515 0.00357 90 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 CD19(1), CR2(1), DAG1(1), INPP5D(1), ITPR1(1), ITPR2(1), ITPR3(1), LYN(2), NFATC1(1), NFATC2(1), PIK3CA(22), PIK3R1(8), PPP3CB(1) 6286667 42 26 33 4 7 6 4 15 10 0 0.0148 0.000533 0.00365 91 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 CASP8(2), CD14(1), CD80(2), CD86(1), IFNA16(1), IFNA2(2), IFNA7(1), IKBKB(1), IL12A(1), IL1B(2), IRAK4(1), LBP(1), MAP2K4(1), MAP3K8(2), MAPK10(1), MAPK9(1), MYD88(1), PIK3CA(22), PIK3CG(2), PIK3R1(8), RAC1(1), STAT1(1), TBK1(1), TLR1(1), TLR2(2), TLR4(1), TLR5(1), TLR6(2), TLR7(1), TLR8(1) 7612994 66 32 57 6 8 8 18 18 14 0 0.00138 0.000849 0.00574 92 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), E2F1(1), RB1(6) 710863 8 7 8 0 1 0 0 2 4 1 0.160 0.00113 0.00754 93 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 E2F1(1), RB1(6), UBE2M(2) 718601 9 7 9 0 2 0 0 2 4 1 0.110 0.00127 0.00838 94 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR3(1), NCK1(2), NCKAP1(3), NTRK1(2), PSMA7(1), RAC1(1), WASF1(1), WASF3(1), WASL(1) 1290167 14 9 14 1 5 1 4 1 3 0 0.0740 0.00184 0.0121 95 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 FCER1A(1), LYN(2), MAP2K4(1), MAP3K1(1), NFATC1(1), NFATC2(1), PIK3CA(22), PIK3R1(8), PPP3CB(1) 3660578 38 26 29 6 5 6 4 13 10 0 0.169 0.00222 0.0144 96 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3E(1), MAP2K4(1), MAP3K1(1), NFATC1(1), NFATC2(1), PIK3CA(22), PIK3R1(8), PPP3CB(1), RAC1(1), RASA1(1) 4079930 38 29 29 7 5 7 5 11 10 0 0.208 0.00253 0.0162 97 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 BCL2L1(1), CDKN2A(1), CREB5(1), ERBB4(1), GAB1(1), IGFBP1(1), INPPL1(1), IRS1(2), IRS4(1), MET(2), MYC(2), PAK4(2), PARD3(1), PIK3CA(22), PREX1(1), PTEN(15), RPS6KA2(1), SLC2A4(1), TSC1(1) 6581763 58 27 48 6 7 8 15 16 10 2 0.00325 0.00304 0.0193 98 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), DAG1(1), EPHB2(2), FBXW7(24), ITK(1), ITPKA(1), ITPKB(2), NCK1(2), NFAT5(2), PAK4(2), RASGRP1(1), RASGRP4(1) 4741699 40 28 31 5 15 6 10 4 5 0 0.0115 0.00324 0.0204 99 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(2), HLA-DRA(1), IL1B(2), IL5RA(1) 453522 6 5 6 0 2 1 3 0 0 0 0.140 0.00397 0.0247 100 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD80(2), HLA-DRA(1), IL2(1) 337807 4 4 4 0 2 1 1 0 0 0 0.228 0.00739 0.0455 101 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND1(1), CCND2(1), CDK6(1), CDKN2A(1), CDKN2B(1), E2F1(1), RB1(6) 1353906 13 8 13 0 4 1 1 2 4 1 0.0279 0.00945 0.0577 102 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), SNCAIP(2), UBE2G1(2) 546771 7 5 7 1 2 2 1 1 1 0 0.278 0.0149 0.0900 103 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(2), BCL10(1), BCL2L1(1), BCL2L11(2) 919398 6 6 5 1 2 1 0 0 3 0 0.486 0.0155 0.0926 104 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(1), IL2(1), IL2RA(1), TGFB1(1), TGFBR3(1), TOB2(1) 897887 6 6 6 0 2 2 0 1 1 0 0.116 0.0172 0.102 105 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(5), AXIN2(1), BTRC(1), CAMK2B(1), CAMK2D(1), CAMK2G(1), CCND1(1), CCND2(1), CHD8(3), CREBBP(6), CSNK2B(1), CTBP2(2), DAAM1(4), DKK1(2), DVL1(2), DVL3(1), EP300(1), FBXW11(1), FZD2(1), FZD3(1), LRP5(1), LRP6(3), MAPK10(1), MAPK9(1), MYC(2), NFAT5(2), NFATC1(1), NFATC2(1), NKD1(1), NLK(1), PLCB2(1), PLCB3(1), PPP2R1A(17), PPP2R2B(1), PPP3CB(1), PRICKLE2(1), PRKCG(1), PRKX(1), PSEN1(1), RAC1(1), RAC3(1), ROCK2(4), SFRP4(1), SIAH1(2), SMAD4(1), SOX17(1), TBL1XR1(1), TCF7L2(1), TP53(55), WNT10A(1), WNT16(1), WNT2B(2), WNT4(1), WNT5B(2), WNT8B(1), WNT9B(2) 13719830 154 56 135 20 48 17 31 30 26 2 3.50e-06 0.0228 0.134 106 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(1), ARAF(1), BRAF(1), CBL(1), CBLB(3), EXOC7(1), FASN(1), GCK(1), GYS2(1), IKBKB(1), INPP5D(1), INSR(1), IRS1(2), IRS4(1), KRAS(7), LIPE(1), MAPK10(1), MAPK9(1), NRAS(1), PCK1(1), PDE3A(1), PDE3B(1), PFKL(1), PFKP(1), PHKA1(1), PHKA2(2), PIK3CA(22), PIK3CG(2), PIK3R1(8), PPP1CB(1), PPP1R3A(4), PRKAR1A(1), PRKAR2A(1), PRKX(1), PTPRF(1), PYGM(2), SLC2A4(1), SOCS2(1), TSC1(1) 13722150 82 39 68 9 15 13 23 15 16 0 0.000726 0.0290 0.168 107 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(2), HLA-DRA(1) 259845 3 3 3 0 1 1 1 0 0 0 0.316 0.0292 0.168 108 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), ERBB3(5), NRG1(1) 875639 8 5 8 1 2 1 4 0 1 0 0.316 0.0357 0.204 109 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT2(1), GAA(1), GCK(1), GLA(1), HK2(1), LCT(2), MGAM(7), PFKL(1), PFKP(1), PGM3(1), RDH14(2), UGP2(1) 3288784 20 13 20 3 5 4 4 4 3 0 0.0812 0.0384 0.217 110 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A7(2), XDH(1) 677093 5 5 5 1 1 1 2 1 0 0 0.541 0.0411 0.230 111 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 SDHA(2), UQCRC1(2) 560922 4 4 4 0 0 0 2 1 1 0 0.416 0.0430 0.238 112 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(2), HSPB1(1), IL1A(1) 959865 5 5 5 1 1 1 0 1 2 0 0.398 0.0518 0.285 113 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(2), CPOX(1), PPOX(1) 654289 4 4 4 1 3 0 0 0 1 0 0.660 0.0614 0.334 114 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(1), UXS1(2) 322847 4 3 4 0 0 0 3 1 0 0 0.461 0.0668 0.361 115 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), GAA(1), GCK(1), GLA(1), HK2(1), LCT(2), MGAM(7), PFKP(1), PGM3(1) 2772815 16 11 16 3 4 4 3 3 2 0 0.139 0.0761 0.407 116 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(1), ACVR1B(1), BMP4(1), BMPR2(1), CDKN2B(1), CREBBP(6), EP300(1), FST(1), GDF6(1), INHBA(1), LTBP1(1), MYC(2), PPP2R1A(17), PPP2R2B(1), ROCK2(4), SMAD4(1), SP1(1), TGFB1(1), THBS2(1), ZFYVE16(2), ZFYVE9(2) 8431319 48 28 41 5 15 4 9 9 11 0 0.00445 0.0771 0.407 117 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1), GNAQ(1), ITPKA(1), ITPKB(2) 509992 5 4 5 1 1 0 2 2 0 0 0.609 0.0774 0.407 118 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(2), NOTCH1(2), PSEN1(1) 806181 5 5 5 1 2 1 0 1 1 0 0.379 0.0828 0.432 119 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(1), F2(1), FGA(1), FGB(2), FGG(2), SERPINB2(1) 1134412 8 5 8 1 2 0 1 1 4 0 0.347 0.0906 0.467 120 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ7(1), NDUFA13(1) 338647 2 2 2 0 1 1 0 0 0 0 0.456 0.0910 0.467 121 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1) 95559 1 1 1 0 0 1 0 0 0 0 0.640 0.0999 0.508 122 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 HMGCL(1), OXCT1(1) 283309 2 2 2 0 1 0 1 0 0 0 0.594 0.101 0.508 123 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(1), UGP2(1), UXS1(2) 412165 5 3 5 0 1 0 3 1 0 0 0.323 0.101 0.508 124 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK2(2), JAK3(3), STAT3(2) 992129 7 5 7 0 2 1 0 3 1 0 0.163 0.112 0.555 125 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(2), CPO(1), GATA1(1), HBA1(1) 686118 5 4 5 1 2 0 0 0 3 0 0.624 0.120 0.590 126 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 GOT1(1), YARS(3) 698545 4 4 4 1 1 0 2 0 1 0 0.667 0.121 0.592 127 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR3(1), RAC1(1), WASF1(1), WASL(1) 686853 5 4 5 1 1 0 2 1 1 0 0.591 0.123 0.595 128 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 HLA-DRA(1), IL12A(1), IL1A(1), IL2(1), LTA(1), TGFB1(1) 1137300 6 5 6 0 1 1 1 3 0 0 0.176 0.125 0.595 129 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IL12A(1), IL2(1) 245934 2 2 2 0 1 0 1 0 0 0 0.586 0.125 0.595 130 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(1), CD3E(1), KITLG(1) 522746 3 3 3 0 0 1 1 0 1 0 0.506 0.126 0.595 131 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 127352 1 1 1 0 0 0 0 1 0 0 0.756 0.137 0.645 132 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRA(1), IL12A(1), IL2(1), IL2RA(1) 1068516 5 4 5 0 1 2 1 1 0 0 0.170 0.144 0.674 133 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRA(1) 203680 1 1 1 0 0 1 0 0 0 0 0.575 0.154 0.715 134 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH2(1), HMGCL(1), HMGCS2(1), OXCT1(1) 605376 4 3 4 0 3 0 1 0 0 0 0.281 0.160 0.736 135 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(1), HMGCR(1), LSS(1), NSDHL(1), SQLE(1) 1112016 6 5 6 1 0 1 1 2 2 0 0.553 0.164 0.747 136 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT2(1), B4GALT3(1), ST3GAL4(1) 683062 4 4 4 0 1 0 1 1 1 0 0.465 0.166 0.747 137 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(6), EP300(1), NCOA1(1), NCOA2(1) 1567268 9 6 9 0 3 1 1 1 3 0 0.113 0.166 0.747 138 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), CHST12(1), SULT1A1(1), SULT2A1(3) 785284 6 4 6 0 1 0 1 4 0 0 0.258 0.167 0.747 139 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(2), ARHGAP5(3), CASP8(2), GZMB(1) 1086781 8 4 8 1 2 1 2 1 2 0 0.281 0.170 0.751 140 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(6), EP300(1), PELP1(1) 1248027 8 5 8 0 4 1 0 1 2 0 0.0868 0.177 0.777 141 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(1), MAP2(4), PRKAR2A(1), PRKCE(1) 1534847 7 6 7 1 1 1 1 3 1 0 0.438 0.179 0.781 142 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1) 356793 2 2 2 0 1 0 0 0 1 0 0.540 0.183 0.792 143 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 JAK2(2), JAK3(3), STAT1(1), STAT3(2) 1563458 8 6 8 1 2 1 1 3 1 0 0.384 0.189 0.809 144 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(1), CLTB(1), COPA(1), GBF1(1), GPLD1(1), KDELR1(1), KDELR2(1) 1375384 7 4 7 1 1 0 0 2 3 1 0.396 0.189 0.809 145 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(6), EP300(1), PRKAR1A(1), PRKAR2A(1) 1755686 9 7 9 1 4 1 1 1 2 0 0.219 0.192 0.817 146 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 MPO(1), TPO(1), TYR(1) 825016 3 3 3 0 0 0 1 1 1 0 0.454 0.196 0.824 147 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(5), CREBBP(6), EP300(1), TGFB1(1) 2181871 13 6 13 0 3 2 1 4 2 1 0.0268 0.197 0.824 148 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4B(1), INPP5A(1), INPPL1(1), ITPKA(1), ITPKB(2), OCRL(2), PIK3C2A(1), PIK3C2G(2), PIK3CA(22), PIK3CG(2), PLCB2(1), PLCB3(1) 3772836 37 23 28 7 5 6 9 14 2 1 0.137 0.206 0.856 149 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 SPCS3(1) 257718 1 1 1 0 0 0 1 0 0 0 0.814 0.210 0.870 150 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(1), TH(1) 514383 4 3 4 1 1 1 1 1 0 0 0.507 0.212 0.872 151 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 KERA(1), LUM(2) 310545 3 2 3 0 0 1 1 1 0 0 0.368 0.214 0.872 152 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 IL1A(1), STAT1(1), STAT3(2) 1030770 4 4 4 1 0 0 1 2 1 0 0.858 0.215 0.872 153 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 140441 1 1 1 1 0 0 0 0 1 0 0.959 0.217 0.874 154 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA3(1), GABRA4(2), GABRA6(1), PRKCE(1) 664776 6 4 6 4 0 0 4 0 2 0 0.959 0.227 0.908 155 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 JAK2(2), JAK3(3), STAT3(2) 1294686 7 5 7 0 2 1 0 3 1 0 0.161 0.235 0.932 156 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2) 453197 2 2 2 1 1 1 0 0 0 0 0.801 0.236 0.932 157 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(2), BRAF(1), CREB5(1) 927155 4 4 4 1 0 1 0 0 3 0 0.706 0.241 0.943 158 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), GNB1(1), ITGA1(2), ITGB1(1), TBXAS1(2) 2064304 7 6 7 0 1 1 0 2 3 0 0.171 0.242 0.943 159 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(2) 276283 2 2 2 0 0 0 1 1 0 0 0.678 0.244 0.943 160 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK2(1), PGM3(1), TGDS(1) 873232 4 4 4 0 1 2 0 1 0 0 0.204 0.245 0.943 161 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(2), APC(5), BTRC(1), DVL1(2), NOTCH1(2), PSEN1(1) 1846136 13 7 13 2 4 2 1 4 1 1 0.154 0.247 0.943 162 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 144907 1 1 1 0 0 1 0 0 0 0 0.623 0.248 0.943 163 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 GNAS(2), GNB1(1), PRKAR1A(1) 587001 4 4 4 0 1 1 1 1 0 0 0.331 0.253 0.948 164 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CD3E(1), CREBBP(6), GNAS(2), GNB1(1), HLA-DRA(1), PRKAR1A(1), PRKAR2A(1) 1983994 13 7 13 1 5 4 1 2 1 0 0.0479 0.254 0.948 165 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CD3E(1), CREBBP(6), GNAS(2), GNB1(1), HLA-DRA(1), PRKAR1A(1), PRKAR2A(1) 1983994 13 7 13 1 5 4 1 2 1 0 0.0479 0.254 0.948 166 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), HMGCR(1), LSS(1), SQLE(1) 935020 4 4 4 1 0 1 1 1 1 0 0.700 0.255 0.948 167 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(5), BTRC(1), CCND1(1), CREBBP(6), DVL1(2), MYC(2), NLK(1), TLE1(1) 2487208 19 9 19 2 6 3 1 5 3 1 0.0676 0.257 0.949 168 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(2), CMA1(1), CPA3(1), ENPEP(2), LNPEP(1) 1794084 9 5 9 1 2 0 4 3 0 0 0.286 0.266 0.968 169 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(1), ALDH3A1(1), UGDH(1) 720372 3 3 3 1 2 0 1 0 0 0 0.621 0.266 0.968 170 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH14(2) 405932 2 2 2 0 0 0 1 1 0 0 0.657 0.272 0.985 171 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT5(1), FUT1(1), ST3GAL4(1) 615532 3 3 3 0 1 0 1 1 0 0 0.456 0.279 1.000 172 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP19(1), SRP72(1) 636635 2 2 2 1 0 0 1 0 1 0 0.958 0.281 1.000 173 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(1), GPR34(2), GPR39(1), GPR45(1) 837581 6 3 6 1 2 0 1 3 0 0 0.400 0.286 1.000 174 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1) 1985632 6 5 6 1 2 1 0 2 1 0 0.413 0.288 1.000 175 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(6), EP300(1), IKBKB(1), IL1B(2), MYD88(1), TLR2(2) 2514274 13 8 13 1 4 1 3 3 2 0 0.126 0.290 1.000 176 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 IL6ST(1), JAK2(2), JAK3(3), PTPN11(1), STAT3(2) 2041174 9 6 9 0 2 2 0 4 1 0 0.0746 0.292 1.000 177 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(1), TYR(1) 395889 2 2 2 1 0 0 0 1 1 0 0.876 0.293 1.000 178 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 IFNA16(1), IFNA2(2), IFNA7(1), PIK3C3(4), ULK1(1) 1776530 9 5 9 0 2 0 5 1 1 0 0.106 0.301 1.000 179 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3E(1) 272223 1 1 1 1 0 1 0 0 0 0 0.923 0.304 1.000 180 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 GNAS(2), GNB1(1), ITGB1(1), KLK2(1), MYC(2), PTPRR(1), RPS6KA5(1), STAT3(2) 2839766 11 8 11 1 2 1 1 6 1 0 0.212 0.309 1.000 181 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(5), CREB5(1), DAG1(1), EPHB2(2), GNAQ(1), ITPKA(1), ITPKB(2), MAP2K4(1), MAPK10(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(1) 2425160 20 8 20 3 6 1 4 5 3 1 0.114 0.312 1.000 182 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(5), BMP10(1), BMP4(1), BMPR2(1), DVL1(2), GATA4(1), MEF2C(1), RFC1(3), TGFB1(1), TGFBR3(1) 3116406 18 7 18 1 4 1 2 6 4 1 0.0354 0.315 1.000 183 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(2), BCL2L1(1), CASP7(1), CASP8(2) 1128816 6 4 6 1 3 1 0 0 2 0 0.318 0.320 1.000 184 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT1(1) 529415 2 2 2 1 1 0 1 0 0 0 0.791 0.320 1.000 185 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IKBKB(1), IL2(1), MAP3K1(1), MAP3K5(2) 1613047 5 5 5 0 3 0 1 0 1 0 0.273 0.328 1.000 186 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ARAF(1), BRAF(1), CACNA1C(2), CAMK2B(1), CAMK2D(1), CAMK2G(1), CREBBP(6), EP300(1), GNAQ(1), GRIA1(2), GRIN2A(2), GRM1(2), GRM5(1), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(7), NRAS(1), PLCB2(1), PLCB3(1), PPP1CB(1), PPP3CB(1), PRKCG(1), PRKX(1), RAP1A(1), RAPGEF3(1), RPS6KA2(1), RPS6KA6(2) 8464878 44 21 39 4 13 8 10 4 9 0 0.00185 0.331 1.000 187 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK2(1), PGM3(1), TGDS(1) 1002144 4 4 4 0 1 2 0 1 0 0 0.197 0.338 1.000 188 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(1), ERBB2(1), ERBB4(1), ETV6(1), FMN2(5), KRAS(7), NOTCH1(2), NOTCH3(1), NOTCH4(1), PIWIL1(1), PIWIL3(3), PIWIL4(2), SPIRE1(1), SPIRE2(2) 4466784 29 16 24 4 9 3 8 5 4 0 0.0687 0.348 1.000 189 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(1), MTMR6(1) 541383 3 2 3 0 1 1 0 1 0 0 0.374 0.353 1.000 190 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 DLG4(1), EPHB2(2), F2(1), F2RL1(2), MAPK7(1), PLD3(1), TEC(2) 2340726 10 6 10 1 2 1 1 3 3 0 0.285 0.364 1.000 191 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 KHK(1), LCT(2), PYGM(2) 1145006 5 4 5 1 2 1 2 0 0 0 0.381 0.370 1.000 192 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ITPKA(1), PDE1A(2), PDE1B(2), PLCB2(1), VIP(1) 942811 7 3 7 1 2 0 2 3 0 0 0.420 0.371 1.000 193 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA4(1), PSMA7(1), PSMB1(1), PSMD11(1), PSMD2(1) 1345236 5 4 5 1 2 0 1 2 0 0 0.582 0.378 1.000 194 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 MPO(1), TPO(1) 717978 2 2 2 0 0 0 1 0 1 0 0.556 0.381 1.000 195 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AMY2A(1), AMY2B(1), ENPP1(1), ENPP3(1), GAA(1), GCK(1), GYS2(1), HK2(1), MGAM(7), PGM3(1), PYGM(2), SI(7), UGDH(1), UGT1A5(1), UGT1A6(1), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1), UXS1(2) 4808243 35 18 35 5 8 5 10 8 4 0 0.0424 0.384 1.000 196 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), CMA1(1), COL4A1(2), COL4A2(1), COL4A4(1), COL4A5(4), COL4A6(1) 2131707 12 7 12 2 2 0 7 1 2 0 0.395 0.387 1.000 197 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(2), POLR2B(1) 1132733 4 3 4 1 1 1 0 2 0 0 0.581 0.394 1.000 198 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(2), ERBB4(1), NRG3(1), PSEN1(1) 767955 5 3 5 0 2 0 0 2 1 0 0.240 0.396 1.000 199 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(1), ADH4(1), ADH6(2) 471088 4 2 4 0 0 1 3 0 0 0 0.393 0.398 1.000 200 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACPP(1), ENPP1(1), ENPP3(1), MTMR1(1), MTMR2(1), MTMR6(1), TYR(1) 1273220 7 4 7 0 2 1 1 3 0 0 0.134 0.404 1.000 201 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSB(2), GOT1(1), YARS(3), YARS2(1) 732652 7 5 7 2 1 0 2 2 2 0 0.717 0.408 1.000 202 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(1), GABRA3(1), GABRA4(2), GABRA6(1) 1012393 5 4 5 5 0 0 3 0 2 0 0.989 0.408 1.000 203 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 CNR1(2), CNR2(1), MTNR1A(1) 961149 4 4 4 1 2 0 2 0 0 0 0.601 0.413 1.000 204 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(2), LCT(2), MAN2C1(1) 1417908 6 6 6 2 2 1 2 0 1 0 0.568 0.415 1.000 205 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(2), GNB1(1), PRKAR1A(1), PRKAR2A(1) 839725 5 4 5 1 2 1 1 1 0 0 0.574 0.416 1.000 206 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 SULT2A1(3) 515505 3 2 3 0 0 0 0 3 0 0 0.483 0.421 1.000 207 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 SQLE(1) 265133 1 1 1 0 0 0 0 0 1 0 1.000 0.428 1.000 208 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12A(1), IL16(2), IL1A(1), IL2(1), LTA(1) 836018 6 3 6 0 1 0 3 2 0 0 0.235 0.428 1.000 209 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCND1(1), CCNE2(1), CDKN2A(1), E2F1(1) 774134 5 3 5 0 1 1 1 2 0 0 0.217 0.429 1.000 210 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA11(1), NDUFB5(1), NDUFV2(1) 587934 3 2 3 0 0 0 0 1 2 0 0.395 0.433 1.000 211 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(2) 717366 2 2 2 1 0 1 0 1 0 0 0.822 0.433 1.000 212 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), RELN(1) 1190976 3 3 3 1 0 0 1 0 2 0 0.945 0.440 1.000 213 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(1), CREBBP(6), GZMB(1), NME1(1) 895644 10 5 10 2 5 2 1 1 1 0 0.273 0.441 1.000 214 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1) 219503 1 1 1 1 0 0 0 0 1 0 0.948 0.444 1.000 215 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(1), NR1H4(2) 461958 3 2 3 0 2 0 0 1 0 0 0.356 0.445 1.000 216 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPP(1), ENPP1(1), ENPP3(1), TYR(1) 824787 4 3 4 0 1 0 1 2 0 0 0.379 0.445 1.000 217 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), ARG1(1) 473335 3 2 3 0 0 0 2 1 0 0 0.547 0.448 1.000 218 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 GART(2), MTHFS(1), MTR(1), TYMS(1) 1512637 5 4 5 1 2 0 1 1 1 0 0.453 0.453 1.000 219 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 GMDS(1), GMPPA(1), HK2(1), KHK(1), MTMR1(1), MTMR2(1), MTMR6(1), PFKFB1(1), PFKL(1), PFKP(1), PGM2(2), RDH14(2) 3162858 14 8 14 1 5 2 3 3 1 0 0.0619 0.459 1.000 220 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AMY2A(1), AMY2B(1), ASCC3(1), ATP13A2(1), DDX4(3), DDX51(1), DDX54(1), DDX55(2), DDX56(1), DHX58(2), ENPP1(1), ENPP3(1), EP400(2), GAA(1), GCK(1), GYS2(1), HK2(1), MGAM(7), NUDT5(1), PGM3(1), PYGM(2), RAD54B(1), RAD54L(2), SI(7), SKIV2L2(2), SMARCA2(2), SMARCA5(1), UGDH(1), UGP2(1), UGT1A5(1), UGT1A6(1), UGT1A7(1), UGT1A9(1), UGT2B10(1), UGT2B11(1), UGT2B15(2), UGT2B28(1), UGT2B4(1), UXS1(2) 10448089 62 25 62 7 12 9 18 13 10 0 0.00175 0.459 1.000 221 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 PFKL(1), PGAM1(1) 796878 2 2 2 0 1 0 0 0 1 0 0.663 0.463 1.000 222 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 GCK(1), GMDS(1), GMPPA(1), HK2(1), KHK(1), PFKFB1(1), PFKP(1) 2043454 7 6 7 1 4 1 2 0 0 0 0.228 0.467 1.000 223 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(1), CASP8(2), CRADD(1), MADD(1), MAP2K4(1), MAP3K1(1), PRKDC(2), RB1(6) 3271995 15 9 15 3 2 1 1 1 9 1 0.496 0.471 1.000 224 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), GNB1(1) 605090 2 2 2 0 2 0 0 0 0 0 0.484 0.473 1.000 225 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1) 333142 1 1 1 1 0 0 0 0 1 0 0.960 0.473 1.000 226 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(1) 171828 1 1 1 0 0 0 0 1 0 0 0.806 0.474 1.000 227 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP7(1), CASP8(2), CFLAR(1), MAP2K4(1), MAP3K1(1), PRKDC(2), PTPN13(1), RB1(6) 3388506 15 8 15 5 2 1 0 3 8 1 0.868 0.477 1.000 228 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BRAF(1), CD247(1), CD48(1), GZMB(1), HLA-B(1), HLA-C(1), HLA-E(1), IFNA16(1), IFNA2(2), IFNA7(1), ITGAL(1), KIR3DL1(2), KLRC3(1), KRAS(7), NFAT5(2), NFATC1(1), NFATC2(1), NRAS(1), PIK3CA(22), PIK3CG(2), PIK3R1(8), PPP3CB(1), PRKCG(1), PTPN11(1), PTPN6(1), RAC1(1), RAC3(1), ULBP2(1), VAV2(1) 9640336 68 36 54 12 9 13 15 20 11 0 0.0318 0.480 1.000 229 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT2(1), IARS2(1), LARS2(1), VARS2(1) 1583936 4 4 4 1 1 1 0 1 1 0 0.710 0.482 1.000 230 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(1) 455431 1 1 1 0 1 0 0 0 0 0 0.661 0.482 1.000 231 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2) 331087 2 1 2 1 1 0 0 0 1 0 0.888 0.487 1.000 232 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(2), ITGA1(2), ITGB1(1), L1CAM(3), LYN(2), SELP(2) 1337759 14 7 14 3 3 2 2 5 2 0 0.289 0.492 1.000 233 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ATF3(1), IL1A(1), IL1R1(1), NR4A3(1) 903232 4 3 4 1 0 0 1 2 1 0 0.630 0.495 1.000 234 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(1), IL1A(1), KITLG(1), TGFB1(1) 708967 4 2 4 0 0 0 1 2 1 0 0.449 0.496 1.000 235 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), NOX1(1), XDH(1) 838243 3 3 3 1 1 0 1 0 1 0 0.873 0.501 1.000 236 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IRS1(2), JAK3(3) 1264655 5 4 5 1 2 0 1 1 1 0 0.538 0.507 1.000 237 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 LCT(2), ST6GALNAC3(2), ST6GALNAC5(1) 1394266 5 4 5 1 0 1 3 1 0 0 0.496 0.514 1.000 238 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(3), ABCB11(2), ABCB4(2), ABCC1(2) 1217771 9 3 9 0 3 1 1 3 1 0 0.0615 0.515 1.000 239 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(1), GFPT1(1), HK2(1), PGM3(1), RENBP(1), UAP1(1) 1446205 6 4 6 0 1 2 2 1 0 0 0.143 0.518 1.000 240 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ADRBK2(1), CAMK2B(1), CAMK2D(1), CAMK2G(1), CLCA1(1), CLCA4(2), CNGA3(1), CNGB1(2), PDC(1), PDE1C(1), PRKX(1) 2593052 14 6 14 1 3 2 2 2 5 0 0.0586 0.522 1.000 241 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 SQLE(1) 356782 1 1 1 0 0 0 0 0 1 0 1.000 0.522 1.000 242 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 ANKRD6(1), APC(5), AXIN2(1), DKK1(2), DVL1(2), LRP1(3), NKD1(1), PSEN1(1), PTPRA(1) 3457319 17 9 17 2 5 2 3 4 2 1 0.101 0.524 1.000 243 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), CASP8(2) 718745 3 2 3 1 1 0 1 0 1 0 0.698 0.524 1.000 244 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(2), ABCC2(4), ABCG2(1), BCHE(2), UGT1A5(1), UGT1A6(1), UGT1A7(1), UGT1A9(1) 1935332 13 6 13 2 5 0 2 4 2 0 0.261 0.531 1.000 245 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F5(1), FGA(1), FGB(2), FGG(2), PROS1(3), SERPINC1(2), TFPI(2) 1384576 15 5 15 3 2 1 3 3 6 0 0.284 0.532 1.000 246 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 RDH14(2) 762009 2 2 2 0 0 0 1 1 0 0 0.650 0.538 1.000 247 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 MPO(1), TPO(1) 984391 2 2 2 0 0 0 1 0 1 0 0.561 0.546 1.000 248 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK2(2), STAT1(1) 688529 3 2 3 1 0 1 1 1 0 0 0.811 0.550 1.000 249 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 MPO(1), TPO(1) 1003159 2 2 2 0 0 0 1 0 1 0 0.551 0.557 1.000 250 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), HSPB1(1), TUBA8(1) 944723 3 3 3 0 0 1 1 0 1 0 0.449 0.563 1.000 251 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), IL1B(2), TGFB1(1) 1135420 5 3 5 0 1 0 3 1 0 0 0.279 0.565 1.000 252 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(1), CAMK2D(1), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(2), ITPR1(1), ITPR2(1), ITPR3(1), NFAT5(2), PDE6A(1), PDE6B(1), TF(1) 3044425 15 7 15 2 3 2 5 3 2 0 0.170 0.568 1.000 253 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFLAR(1) 328362 3 1 3 0 1 0 0 1 1 0 0.466 0.574 1.000 254 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 IL1B(2) 559161 2 2 2 0 0 0 2 0 0 0 0.635 0.581 1.000 255 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(1), ADH4(1), ADH6(2), ALDH1B1(1), ALDH3A1(1) 1111138 6 3 6 1 2 1 3 0 0 0 0.366 0.582 1.000 256 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(2), LCT(2), MAN2C1(1) 1746858 6 6 6 2 2 1 2 0 1 0 0.546 0.584 1.000 257 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 IL2(1) 517765 1 1 1 0 1 0 0 0 0 0 0.651 0.585 1.000 258 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), IL3RA(1), JAK2(2), PTPN6(1) 1497396 5 3 5 1 0 1 0 3 1 0 0.621 0.589 1.000 259 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 RRM1(1), SRM(1) 1070438 2 2 2 1 1 0 0 0 1 0 0.879 0.589 1.000 260 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA4(1), PSMA7(1), PSMB1(1), RPN2(1), UBE3A(1) 1078035 5 3 5 1 3 0 1 1 0 0 0.536 0.595 1.000 261 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 G6PD(1), H6PD(1), PFKL(1), PFKP(1), PGM3(1) 2070760 5 5 5 0 1 1 1 1 1 0 0.258 0.604 1.000 262 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(2), GNAQ(1), GNAS(2), GNB1(1), NOX1(1), PIK3C2G(2), ROCK2(4) 2136093 13 5 13 0 4 1 2 3 3 0 0.0409 0.605 1.000 263 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), ST3GAL4(1) 1079460 5 4 5 2 1 0 2 1 1 0 0.788 0.608 1.000 264 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(1), ATP4A(5), ATP5B(1), ATP5H(1), ATP6AP1(1), ATP6V0A2(1), ATP6V0A4(1), ATP6V0D2(2), ATP6V1C1(1), NDUFA11(1), NDUFA13(1), NDUFB5(1), NDUFV2(1), SDHA(2), UQCRC1(2) 4732622 22 14 22 4 5 1 5 5 6 0 0.173 0.610 1.000 265 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(2), CASP4(1), CASP7(1), CASP8(2), GZMB(1) 1633831 7 4 7 2 3 1 1 0 2 0 0.542 0.611 1.000 266 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA4(1), ANXA5(1), ANXA6(1), EDNRB(1), TBXAS1(2) 1760211 6 5 6 2 0 0 1 3 2 0 0.789 0.613 1.000 267 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(2), BAG4(1), CASP7(1), CASP8(2), CFLAR(1), CRADD(1), MAP3K1(1), MAP3K5(2), PRKDC(2), PSEN1(1), RASA1(1), RB1(6) 5834087 21 12 21 2 6 1 2 2 9 1 0.0834 0.614 1.000 268 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(1), COL4A4(1), COL4A5(4), COL4A6(1) 2122312 9 6 9 2 2 0 4 1 2 0 0.488 0.619 1.000 269 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKB(1), MAP3K1(1), TNFAIP3(1) 1534522 3 3 3 1 2 0 0 0 1 0 0.796 0.619 1.000 270 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1) 436192 1 1 1 1 1 0 0 0 0 0 0.890 0.620 1.000 271 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(1), ATP6V1C1(1) 1264117 3 3 3 1 2 0 1 0 0 0 0.654 0.623 1.000 272 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(1), ATP6V1C1(1) 1264117 3 3 3 1 2 0 1 0 0 0 0.654 0.623 1.000 273 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(1), ATP6V1C1(1) 1264117 3 3 3 1 2 0 1 0 0 0 0.654 0.623 1.000 274 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 POLR2A(2), PRKAR1A(1), PRKAR2A(1) 1093519 4 4 4 2 1 1 1 1 0 0 0.751 0.623 1.000 275 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), GNAS(2), GNB1(1), PRKAR1A(1), PRKAR2A(1) 1781470 6 5 6 1 2 1 1 1 1 0 0.374 0.628 1.000 276 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ADH1B(1), ADH4(1), ADH6(2), ALDH1B1(1), ALDH3A1(1), GAPDH(1), GCK(1), HK2(1), PFKL(1), PFKP(1), PGAM1(1), PGAM4(1), PGM3(1) 4938235 14 10 14 2 4 3 4 2 1 0 0.133 0.630 1.000 277 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP2(1), MMP9(1), TIMP1(1) 641199 3 2 3 0 2 0 1 0 0 0 0.332 0.633 1.000 278 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3E(1), GZMB(1), ITGAL(1) 745703 3 2 3 1 0 1 1 1 0 0 0.673 0.634 1.000 279 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ASCC3(1), ATP13A2(1), DDX4(3), DDX51(1), DDX54(1), DDX55(2), DDX56(1), DHX58(2), EP400(2), NUDT5(1), RAD54B(1), RAD54L(2), SKIV2L2(2), SMARCA2(2), SMARCA5(1) 5313033 23 11 23 2 3 4 6 5 5 0 0.0246 0.636 1.000 280 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR2(1) 529306 2 2 2 0 1 0 0 1 0 0 0.582 0.637 1.000 281 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ACADS(1), ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), ALDH5A1(1), GAD1(1), HMGCL(1), OXCT1(1) 2186565 9 6 9 2 6 1 1 0 1 0 0.295 0.641 1.000 282 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC1(2), APOBEC3F(1) 617823 3 3 3 2 2 0 1 0 0 0 0.903 0.643 1.000 283 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(1), ACSL1(2), ACSL4(2), SCP2(1) 1423727 6 3 6 1 1 0 1 2 2 0 0.437 0.646 1.000 284 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 STX19(1), STX3(1), STX7(1) 1422080 3 3 3 0 1 0 0 2 0 0 0.472 0.647 1.000 285 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2) 780318 2 2 2 0 0 0 0 1 1 0 0.664 0.650 1.000 286 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKB(1), LTA(1), MAP3K1(1), TNFAIP3(1) 1903914 4 4 4 0 2 0 0 1 1 0 0.372 0.655 1.000 287 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), GNAQ(1), GNB1(1), MYLK(2) 1747453 7 4 7 1 4 1 1 1 0 0 0.291 0.655 1.000 288 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 G6PD(1), H6PD(1), PFKP(1), PGM3(1) 1744613 4 4 4 0 1 1 1 1 0 0 0.256 0.662 1.000 289 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 DBH(2), GAD1(1), SLC18A3(2), TH(1) 1237102 6 3 6 1 2 2 1 1 0 0 0.261 0.664 1.000 290 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 IDH2(1), SDHA(2) 796624 3 2 3 1 0 0 2 0 1 0 0.784 0.665 1.000 291 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A4(1), ATP6V1C1(1), FDXR(1) 1346814 4 3 4 1 3 0 1 0 0 0 0.525 0.667 1.000 292 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH1B(1), ADH4(1), ADH6(2), ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), CEL(2), CYP7A1(1) 1969047 11 5 11 2 3 1 4 0 3 0 0.423 0.667 1.000 293 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 GNAS(2), GNB1(1), PRKAR1A(1), PRKAR2A(1) 1326580 5 4 5 0 2 1 1 1 0 0 0.221 0.673 1.000 294 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(1), LEPR(1) 1219404 2 2 2 0 0 1 1 0 0 0 0.552 0.678 1.000 295 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK2(2), JAK3(3), PIAS1(1) 1152543 6 3 6 1 2 1 0 3 0 0 0.373 0.679 1.000 296 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 GAPDH(1), GCK(1), GOT1(1), HK2(1), PCK1(1), PFKL(1), PFKP(1), PGAM1(1) 3608609 8 7 8 1 3 1 1 1 2 0 0.275 0.679 1.000 297 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(1) 419534 2 1 2 0 0 0 0 1 1 0 0.645 0.684 1.000 298 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN2(1), ACTN4(1), ARHGAP5(3), CLDN19(1), CLDN20(1), CLDN4(1), CLDN5(1), CTNNA2(2), CTNND1(1), EZR(1), GNAI2(1), GNAI3(1), ITGA4(2), ITGAL(1), ITGAM(1), ITGB1(1), ITK(1), MLLT4(1), MMP2(1), MMP9(1), NCF1(2), NCF2(1), NOX1(1), NOX3(1), OCLN(1), PIK3CA(22), PIK3CG(2), PIK3R1(8), PRKCG(1), PTPN11(1), PXN(1), RAC1(1), RAP1A(1), RAPGEF3(1), RAPGEF4(1), RASSF5(1), ROCK2(4), VAV2(1) 10581851 75 34 66 10 17 11 16 18 13 0 0.00393 0.688 1.000 299 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3E(1), ITGAL(1) 913955 2 2 2 1 0 1 0 1 0 0 0.752 0.688 1.000 300 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15B(1), ALOX5(1), TBXAS1(2) 1270749 4 4 4 2 1 0 0 1 2 0 0.869 0.696 1.000 301 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 LARS2(1) 840220 1 1 1 1 0 0 0 1 0 0 0.950 0.699 1.000 302 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN2(1), ITGA1(2), ITGB1(1), PXN(1), RAC1(1) 2431943 7 6 7 2 1 1 2 2 1 0 0.575 0.700 1.000 303 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACPP(1), CYP1A1(1), CYP1A2(2), CYP2A7(2), CYP2C9(1), CYP2F1(1), CYP4B1(2), CYP51A1(1) 2498715 11 7 11 2 2 2 2 4 1 0 0.355 0.701 1.000 304 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS2(1), AGXT(1), AGXT2(1), ASNS(1), CAD(1), DARS(1), DARS2(2), GAD1(1), GOT1(1) 3211174 10 6 10 1 4 1 1 3 1 0 0.167 0.701 1.000 305 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(2), CCR3(2), CCR6(1), CCR8(1), CX3CR1(1), EDNRB(1), FSHR(1), GALR1(1), GNRHR(1), GRPR(1), LHCGR(4), MC1R(1), MC2R(1), MC3R(2), NPY5R(1), NTSR1(2), OPRD1(1), OPRL1(1), OXTR(1), SSTR4(1), TACR1(1), TRHR(2), TSHR(2) 4486209 35 13 35 9 10 2 9 10 4 0 0.200 0.702 1.000 306 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3E(1), ITGAL(1) 959035 2 2 2 1 0 1 0 1 0 0 0.752 0.703 1.000 307 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), NFATC1(1), NFATC2(1), PRKAR1A(1), PRKAR2A(1) 1041963 5 5 5 2 4 0 1 0 0 0 0.504 0.706 1.000 308 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F12(1), F13B(1), F2(1), F5(1), F8(4), F9(2), FGA(1), FGB(2), FGG(2), LPA(1), SERPINB2(1), VWF(2) 3001221 20 11 20 8 5 2 1 4 8 0 0.586 0.711 1.000 309 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(1), MYC(2) 1318072 3 3 3 0 1 0 1 1 0 0 0.434 0.712 1.000 310 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 CASP7(1), CASP8(2), GAPDH(1), INSR(1), ITCH(2), MAGI2(2), RERE(2), WWP1(3) 2042462 14 6 14 2 3 2 2 5 2 0 0.198 0.722 1.000 311 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ACADS(1), ALDH1B1(1), ALDH3A1(1), ALDH5A1(1), BDH2(1), DDHD1(1), GAD1(1), HMGCL(1), HMGCS2(1), OXCT1(1), PLA1A(1), RDH14(2) 3430764 14 8 14 2 7 1 3 2 1 0 0.101 0.724 1.000 312 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT6(1), ENPP2(1), ENPP6(2), PAFAH1B1(1), PLA2G1B(1) 1966927 6 4 6 0 2 0 1 3 0 0 0.209 0.724 1.000 313 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 IL12A(1), ITGAX(1), TLR2(2), TLR4(1), TLR7(1) 1582831 6 4 6 1 0 0 3 2 1 0 0.552 0.729 1.000 314 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH4(1), ADH6(2), ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), GAPDH(1), GCK(1), HK2(1), PFKP(1), PGAM1(1), PGM3(1) 4146751 14 8 14 3 5 3 4 1 1 0 0.230 0.729 1.000 315 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH4(1), ADH6(2), ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), GAPDH(1), GCK(1), HK2(1), PFKP(1), PGAM1(1), PGM3(1) 4146751 14 8 14 3 5 3 4 1 1 0 0.230 0.729 1.000 316 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), GLA(1), ST3GAL4(1) 859224 3 2 3 1 1 0 0 2 0 0 0.752 0.730 1.000 317 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 PTPRA(1) 782251 1 1 1 0 0 1 0 0 0 0 0.601 0.736 1.000 318 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CLDN5(1), CRY1(1), CRY2(1), EIF4G2(1), ETV6(1), GFRA1(1), MYF6(2), NCKAP1(3), PER2(1), PIGF(1), PSMA4(1), UCP3(1), UGP2(1), ZFR(3) 3097554 19 6 19 2 5 0 6 5 3 0 0.123 0.739 1.000 319 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ADCY3(1), ADCY9(1), ATP6V0A2(1), ATP6V0A4(1), ATP6V0D2(2), ATP6V1C1(1), GNAS(2), PDIA4(2), SEC61A1(2), TRIM23(2) 3141560 15 7 15 2 3 3 1 4 4 0 0.128 0.744 1.000 320 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 KLK2(1) 694066 1 1 1 0 0 0 1 0 0 0 0.791 0.744 1.000 321 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 EP300(1), HIF1A(1), NOS3(2) 1444464 4 3 4 0 0 0 2 0 2 0 0.485 0.745 1.000 322 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 CFTR(1), GNAS(2), PRKAR1A(1), PRKAR2A(1) 1135630 5 3 5 0 1 1 1 1 1 0 0.254 0.747 1.000 323 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACADS(1), ALDH1B1(1), ALDH3A1(1), ALDH6A1(1), BCAT2(1), BCKDHB(1), HIBADH(1), HMGCL(1), HMGCS2(1), OXCT1(1) 3646163 10 8 10 2 6 0 1 1 2 0 0.338 0.750 1.000 324 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT2(2), GALNT3(1), GALNT4(1), GALNT9(1), ST3GAL4(1), WBSCR17(2) 1227071 8 4 8 2 0 1 2 3 2 0 0.586 0.755 1.000 325 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CRY1(1), CRY2(1) 712754 2 2 2 1 1 0 1 0 0 0 0.824 0.758 1.000 326 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1R(1), C2(1), C7(2), C8A(1), C9(1) 1471692 6 3 6 2 1 2 1 0 2 0 0.627 0.760 1.000 327 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK2(2), STAT1(1) 965655 3 2 3 1 0 1 1 1 0 0 0.780 0.760 1.000 328 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(2), ARSE(2), DEGS1(1), ENPP7(1), GALC(2), GLA(1), LCT(2), SGMS1(1), SGMS2(1), SPTLC1(1), UGCG(1), UGT8(1) 3065669 17 6 17 1 5 1 2 4 5 0 0.0468 0.761 1.000 329 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1) 698642 1 1 1 0 1 0 0 0 0 0 0.680 0.775 1.000 330 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1B1(1), ALDH3A1(1) 678479 4 2 4 2 3 0 0 0 1 0 0.746 0.778 1.000 331 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1B1(1), ALDH3A1(1) 678479 4 2 4 2 3 0 0 0 1 0 0.746 0.778 1.000 332 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA4(1), PSMA7(1), PSMB1(1) 731825 3 2 3 1 2 0 0 1 0 0 0.706 0.778 1.000 333 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AGXT(1), AGXT2(1), ASNS(1), CAD(1), DARS(1), GAD1(1), GOT1(1) 2212675 7 4 7 1 3 1 1 1 1 0 0.299 0.779 1.000 334 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 GOT1(1) 577743 1 1 1 1 0 0 0 0 1 0 0.949 0.779 1.000 335 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(1), PIGA(3), PIGC(2), PIGF(1), PIGS(1) 1986052 8 3 8 3 0 1 2 3 2 0 0.792 0.782 1.000 336 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), EGF(2), ITGA1(2), ITGB1(1), MYLK(2), PRKAR1A(1), PRKAR2A(1), PXN(1) 2791331 11 6 11 3 3 1 4 2 1 0 0.517 0.783 1.000 337 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 IL2(1), IL2RA(1), JAK3(3) 1994170 5 4 5 0 3 1 0 1 0 0 0.152 0.783 1.000 338 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3E(1), IL12A(1), JAK2(2) 1254656 4 2 4 1 0 2 1 1 0 0 0.605 0.784 1.000 339 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 FSHR(1), GNAS(2), XPO1(1) 837172 4 2 4 0 1 1 0 2 0 0 0.334 0.788 1.000 340 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP51A1(1), DHCR7(1), HMGCR(1), LSS(1), NSDHL(1), SQLE(1) 1634970 6 5 6 2 0 1 1 2 2 0 0.789 0.795 1.000 341 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 GOT1(1), SULT1B1(1) 1059035 2 2 2 2 0 0 0 0 2 0 0.989 0.799 1.000 342 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2G1(2), UBE2M(2), UBE3A(1) 883379 5 2 5 1 2 1 0 1 1 0 0.419 0.801 1.000 343 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ALG6(1), CCR3(2), CELSR1(1), CELSR2(3), CELSR3(3), CHRM2(2), CHRM3(1), FSHR(1), GNRHR(1), GPR116(1), GPR132(1), GPR133(1), GPR61(1), GPR88(1), GRM1(2), GRPR(1), LGR6(2), LPHN2(2), LPHN3(1), NTSR1(2), OR2M4(1), SMO(1), TSHR(2), VN1R1(1) 5686610 35 12 35 4 9 5 12 5 4 0 0.0127 0.801 1.000 344 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 SIRT1(1), SIRT2(1), VNN2(1) 1011868 3 2 3 0 2 1 0 0 0 0 0.314 0.806 1.000 345 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(1), IL1A(1), IL1R1(1), MAP3K1(1), MYD88(1), TLR4(1), TNFAIP3(1) 2077750 7 5 7 2 2 0 1 2 2 0 0.665 0.809 1.000 346 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 SLC18A3(2) 600278 2 1 2 1 1 1 0 0 0 0 0.691 0.812 1.000 347 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(1), ARHGEF2(1), CD14(1), EZR(1), HCLS1(1), ITGB1(1), KRT18(1), NCK1(2), NCL(1), OCLN(1), ROCK2(4), TLR4(1), TLR5(1), TUBA3C(2), TUBA3D(1), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2B(1), WAS(3), WASL(1) 4463269 30 9 30 3 8 4 4 7 7 0 0.0183 0.812 1.000 348 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(1), ARHGEF2(1), CD14(1), EZR(1), HCLS1(1), ITGB1(1), KRT18(1), NCK1(2), NCL(1), OCLN(1), ROCK2(4), TLR4(1), TLR5(1), TUBA3C(2), TUBA3D(1), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2B(1), WAS(3), WASL(1) 4463269 30 9 30 3 8 4 4 7 7 0 0.0183 0.812 1.000 349 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 GNAS(2), PLCE1(2), PRKAR1A(1), PRKAR2A(1) 1297929 6 3 6 0 2 1 1 1 1 0 0.174 0.812 1.000 350 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), EDNRB(1), EGF(2), MYC(2) 1744522 6 5 6 2 1 0 2 2 1 0 0.681 0.814 1.000 351 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), HGSNAT(1), HYAL2(1), LCT(2), NAGLU(1) 1736536 6 5 6 2 2 1 2 0 1 0 0.559 0.816 1.000 352 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY2(4), ADCY3(1), ADCY6(2), ADCY7(1), ADCY9(1), AKAP12(3), AKAP3(1), AKAP4(2), AKAP6(2), AKAP8(1), AKAP9(1), GNAI2(1), GNAI3(1), GNAQ(1), GNB1(1), GNB5(1), IL18BP(1), ITPR1(1), KRAS(7), NRAS(1), PDE1A(2), PDE1B(2), PDE1C(1), PDE4D(2), PDE8B(1), PLCB3(1), PRKAR1A(1), PRKAR2A(1), PRKCE(1), PRKCG(1), PRKCQ(1), PRKD3(2) 9930459 50 22 45 6 12 7 13 8 10 0 0.00710 0.817 1.000 353 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT1(1), GLA(1) 912063 3 3 3 2 1 0 1 1 0 0 0.912 0.819 1.000 354 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 NFE2L2(1) 767118 1 1 1 1 0 1 0 0 0 0 0.934 0.820 1.000 355 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 ALDH1B1(1), ALDH3A1(1), DLST(1), EHMT1(1), NSD1(5), OGDHL(4), RDH14(2), SETD1A(2), SETDB1(3), SPCS3(1), SUV39H1(1), TMLHE(1) 4933133 23 13 23 4 7 4 3 7 2 0 0.106 0.821 1.000 356 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IKBKB(1), IL1A(1), IL1B(2), IL1R1(1), IL1RAP(1), MAP3K1(1), MYD88(1), TGFB1(1) 2531339 9 6 9 2 2 0 3 3 1 0 0.555 0.822 1.000 357 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(1), GFPT1(1), HK2(1), MTMR1(1), MTMR2(1), MTMR6(1), PGM3(1), RENBP(1), UAP1(1) 2440369 9 4 9 0 1 3 3 2 0 0 0.0606 0.822 1.000 358 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT2(1), DPYD(1), ENPP1(1), ENPP3(1), UPB1(1) 1475795 5 3 5 1 2 0 1 2 0 0 0.494 0.822 1.000 359 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 UGDH(1), UGT1A5(1), UGT1A6(1), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1) 1490709 8 4 8 3 2 0 2 1 3 0 0.776 0.822 1.000 360 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(1), COL4A4(1), COL4A5(4), COL4A6(1), F10(1), F12(1), F2(1), F5(1), F8(4), F9(2), FGA(1), FGB(2), FGG(2), KLKB1(3), PROS1(3), SERPINC1(2) 3760722 32 13 32 6 5 2 8 8 9 0 0.122 0.824 1.000 361 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX5(1), CYP4F2(2), CYP4F3(2), MPO(1), PLA2G1B(1), TBXAS1(2), TPO(1) 2380854 10 7 10 4 2 0 3 2 3 0 0.823 0.832 1.000 362 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), LCT(2), NAGLU(1) 1222513 4 4 4 2 1 1 1 0 1 0 0.711 0.834 1.000 363 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 STAT1(1) 923559 1 1 1 1 0 0 1 0 0 0 0.970 0.837 1.000 364 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 GART(2), MTFMT(1), MTHFS(1), MTR(1), TYMS(1) 1604034 6 5 6 2 2 0 1 1 2 0 0.707 0.839 1.000 365 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C7(2), C8A(1), C9(1) 1048267 4 2 4 1 1 1 0 0 2 0 0.635 0.839 1.000 366 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 HIF1A(1), JAK2(2) 1071085 3 2 3 0 0 1 1 1 0 0 0.416 0.840 1.000 367 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(2), CASP7(1), CASP8(2), GZMB(1), SCAP(1) 1543939 7 3 7 3 4 0 1 0 2 0 0.695 0.840 1.000 368 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 CREB5(1), EEF2K(1), HSPB1(1), IL1R1(1), MAP2K4(1), MAP3K4(4), MAP3K5(2) 2850700 11 10 11 8 2 1 2 2 4 0 0.978 0.845 1.000 369 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), GOT1(1) 664172 2 1 2 2 0 0 0 1 1 0 0.965 0.847 1.000 370 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(6), EP300(1), IKBKB(1) 1903397 8 5 8 2 4 1 0 1 2 0 0.467 0.848 1.000 371 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(2), PTPRB(1), RASA1(1), SPRY1(1) 2115071 6 3 6 2 0 1 2 1 2 0 0.831 0.850 1.000 372 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4B(1), INPP5A(1), INPP5E(1), INPPL1(1), IPMK(1), ITPKA(1), ITPKB(2), OCRL(2), PI4KA(2), PI4KB(2), PIK3C3(4), PIK3CA(22), PIK3CG(2), PIP4K2A(1), PIP4K2B(1), PIP5K1B(1), PLCB2(1), PLCB3(1), PLCD4(1), PLCE1(2), PTEN(15), SYNJ1(2) 6296413 67 31 57 11 9 8 19 17 11 3 0.0202 0.851 1.000 373 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 GNAQ(1), MAP3K1(1), MYC(2), NFATC1(1), NFATC2(1), PPP3CB(1), PRKAR1A(1), PRKAR2A(1), VIP(1) 2373787 10 6 10 3 5 0 1 3 1 0 0.550 0.851 1.000 374 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1R(1), C2(1), C7(2), C8A(1), C9(1) 1794965 6 3 6 2 1 2 1 0 2 0 0.619 0.851 1.000 375 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(2), CPOX(1), HCCS(1), PPOX(1), UGT1A5(1), UGT1A6(1), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1) 2324396 12 7 12 4 3 1 3 1 4 0 0.718 0.852 1.000 376 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA5B(1), CA8(1) 1607813 3 2 3 1 1 1 1 0 0 0 0.720 0.854 1.000 377 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP7(1), GZMB(1), TOP2B(1) 702788 3 1 3 0 1 0 1 0 1 0 0.554 0.859 1.000 378 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD2(1), GRM1(2), PRKAR1A(1), PRKAR2A(1) 1357677 5 3 5 0 3 0 1 0 1 0 0.188 0.865 1.000 379 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1B(1), ADH4(1), ADH6(2), ALDH3A1(1), DBH(2), DCT(2), GOT1(1), TH(1), TPO(1), TYR(1) 2689423 13 7 13 3 1 2 5 3 2 0 0.327 0.870 1.000 380 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD2(1), POLE(1), POLQ(2) 1434389 4 2 4 2 1 0 2 0 1 0 0.874 0.870 1.000 381 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), JAK2(2) 884847 3 1 3 0 0 1 0 2 0 0 0.404 0.871 1.000 382 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), JAK2(2) 884847 3 1 3 0 0 1 0 2 0 0 0.404 0.871 1.000 383 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1) 428439 1 1 1 1 1 0 0 0 0 0 0.844 0.872 1.000 384 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), MAP3K1(1), NCOR2(1) 1470055 4 3 4 2 1 0 2 0 1 0 0.908 0.872 1.000 385 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(1), IL12A(1), JAK2(2) 1587398 4 2 4 1 0 2 1 1 0 0 0.623 0.872 1.000 386 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1B(1), ADH4(1), ADH6(2), AGK(1), AGPAT6(1), ALDH1B1(1), ALDH3A1(1), CEL(2), DAK(1), DGAT1(1), DGKA(2), DGKB(2), DGKI(1), DGKZ(2), GK(1), GLA(1), GPAM(1), LCT(2), MGLL(1), PNLIP(1), PNLIPRP1(2) 4939493 28 13 28 6 5 3 9 5 6 0 0.236 0.876 1.000 387 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1B(1), ADRA2A(1), CHRM2(2), CHRM3(1), CHRM5(1), DRD2(1), DRD3(1), HTR1B(2), HTR1E(1), HTR4(1), HTR5A(1) 2227315 13 7 13 3 4 2 5 1 1 0 0.232 0.884 1.000 388 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(3), WEE1(1) 1156039 4 2 4 1 0 0 1 2 1 0 0.661 0.884 1.000 389 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(1), BTRC(1), DHH(2), FBXW11(1), GLI1(1), GLI2(2), GLI3(1), HHIP(2), LRP2(11), PRKX(1), PTCH1(2), SMO(1), WNT10A(1), WNT16(1), WNT2B(2), WNT4(1), WNT5B(2), WNT8B(1), WNT9B(2), ZIC2(1) 5219207 37 15 37 9 11 3 8 10 5 0 0.232 0.887 1.000 390 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(2), ALG12(1), ALG13(2), ALG6(1), B4GALT2(1), B4GALT3(1), MAN1A2(1), MAN1B1(2), MAN1C1(1), MAN2A1(2), MGAT4A(2), MGAT5(1), RPN2(1) 3608696 19 8 18 4 3 1 7 3 4 1 0.369 0.887 1.000 391 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 STAT1(1) 1064870 1 1 1 1 0 0 1 0 0 0 0.965 0.888 1.000 392 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(1) 490148 1 1 1 0 1 0 0 0 0 0 0.661 0.889 1.000 393 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(1), EEF1B2(1), EEF2K(1), EIF2AK2(1), EIF2S1(1), EIF4G1(1), EIF4G3(1), EIF5(1), GSPT2(1), PABPC1(1), PABPC3(1) 3721853 11 7 11 2 2 2 2 1 4 0 0.313 0.890 1.000 394 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(1), CRHR1(1), EMR1(2), GLP2R(1), GPR64(1), LPHN1(1), LPHN2(2), LPHN3(1) 2263020 10 6 10 3 2 3 3 2 0 0 0.502 0.893 1.000 395 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1B1(1), ALDH3A1(1) 1034933 4 2 4 2 3 0 0 0 1 0 0.748 0.896 1.000 396 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 WEE1(1) 561174 1 1 1 0 0 0 0 1 0 0 0.770 0.898 1.000 397 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL4(1) 481086 1 1 1 0 0 0 0 1 0 0 0.853 0.898 1.000 398 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), ARSB(1), FUCA1(2), HGSNAT(1), HYAL2(1), LCT(2), MAN2C1(1), NAGLU(1) 2950084 10 8 10 3 4 1 3 0 2 0 0.437 0.900 1.000 399 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), EGF(2), MET(2), SH3KBP1(1) 1649053 6 3 6 3 1 0 3 1 1 0 0.901 0.904 1.000 400 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 ENPP1(1), ENPP3(1), NADSYN1(1) 1235934 3 2 3 1 2 0 1 0 0 0 0.702 0.905 1.000 401 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 DNMT3B(1), MAT2B(1), MTFMT(1), MTR(1), SRM(1) 1765705 5 5 5 4 2 0 1 0 2 0 0.957 0.906 1.000 402 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 CASP8(2), MAP2K4(1), MAP3K1(1) 1744248 4 2 4 2 1 0 0 0 3 0 0.913 0.907 1.000 403 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK2B(1), CAMK2D(1), CAMK2G(1) 980489 3 3 3 2 2 1 0 0 0 0 0.816 0.908 1.000 404 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 JAK2(2), PTPN6(1) 1835655 3 2 3 1 0 1 0 1 1 0 0.756 0.910 1.000 405 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), KNG1(1), NOS3(2) 856368 5 1 5 0 2 0 2 0 1 0 0.180 0.912 1.000 406 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 DPYD(1), ENPP1(1), ENPP3(1), UPB1(1) 1186801 4 2 4 1 1 0 1 2 0 0 0.623 0.913 1.000 407 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(1), ARSD(2), ARSE(2), HSD3B2(1), SULT2A1(3), UGT1A5(1), UGT1A6(1), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1) 2325882 16 5 16 5 4 0 2 4 6 0 0.672 0.918 1.000 408 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 B4GALT2(1), B4GALT3(1), MAN1B1(2), MGAT4A(2), MGAT5(1), RPN2(1) 1716550 8 6 7 3 1 1 4 0 2 0 0.722 0.921 1.000 409 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACADS(1), ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), ALDH6A1(1), BCKDHB(1), HIBADH(1), HMGCL(1), OXCT1(1) 3050388 10 6 10 3 5 0 1 1 3 0 0.582 0.922 1.000 410 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(2), ALDH5A1(1), CAD(1), GAD1(1), GFPT1(1), GMPS(2), GOT1(1), NADSYN1(1) 2816357 10 5 10 2 2 1 3 3 1 0 0.447 0.923 1.000 411 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP17A1(1), HSD3B2(1) 586185 2 1 2 1 0 0 2 0 0 0 0.882 0.924 1.000 412 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ADH1B(1), ADH4(1), ADH6(2), ALDH1B1(1), ALDH3A1(1), CEL(2), CYP7A1(1), RDH14(2) 2682491 11 6 11 3 2 1 5 1 2 0 0.578 0.925 1.000 413 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), FUT1(1) 1390222 5 4 5 3 2 0 2 0 1 0 0.893 0.929 1.000 414 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPS7(2), RPL34(1), RPL38(1), RPS2(1), RPS28(1), RPS7(1), RPSA(1) 1890242 8 5 8 2 0 2 3 3 0 0 0.549 0.931 1.000 415 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 CPT1B(1), DGKA(2), DGKB(2), DGKZ(2), LYPLA2(2), PAFAH1B1(1), PLA2G1B(1), PLCB2(1) 4224242 12 8 12 6 2 0 4 2 4 0 0.930 0.934 1.000 416 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT6(1), DGKA(2), DGKB(2), DGKI(1), DGKZ(2), ESCO1(1), GPAM(1), LYPLA2(2), PLA2G1B(1) 5556478 13 10 13 5 3 0 2 2 6 0 0.822 0.934 1.000 417 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(1), CYP1A2(2), CYP2C9(1), CYP3A43(1), PLA2G1B(1), RDH14(2) 2029894 8 4 8 2 2 1 2 3 0 0 0.586 0.935 1.000 418 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(1), ARSD(2), ARSE(2), GALC(2), GLA(1), LCT(2), SPTLC1(1), UGCG(1) 2058406 13 4 13 2 4 1 1 2 5 0 0.274 0.935 1.000 419 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(5), CREBBP(6), DVL1(2), EP300(1), TRRAP(3) 2826627 17 6 17 3 6 3 1 4 2 1 0.156 0.936 1.000 420 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 DNMT3B(1), MAT2B(1), MTR(1) 1481843 3 3 3 2 1 0 1 0 1 0 0.876 0.936 1.000 421 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1B(1), GLI2(2), GLI3(1), PRKAR1A(1), PRKAR2A(1), SMO(1) 1423192 7 4 7 4 2 1 2 2 0 0 0.820 0.938 1.000 422 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 GTF2E1(1), GTF2E2(1), GTF2H1(1), GTF2H4(1), MNAT1(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), TAF5(3), TAF7(1) 2963943 15 8 15 3 4 2 3 5 1 0 0.348 0.938 1.000 423 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(1), HSD3B2(1) 682566 3 1 3 0 0 0 2 0 1 0 0.572 0.939 1.000 424 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 DLST(1), IDH2(1), PCK1(1), SDHA(2), SUCLG1(1) 1746850 6 4 6 2 1 2 2 0 1 0 0.576 0.940 1.000 425 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1B(1), ADH4(1), ADH6(2), ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), CEL(2), DGAT1(1), DGKA(2), DGKB(2), DGKZ(2), GK(1), GLA(1), LCT(2), PNLIP(1), PNLIPRP1(2) 4063462 24 9 24 7 5 3 8 3 5 0 0.499 0.940 1.000 426 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR3(2), IL12A(1), IL2(1), TGFB1(1) 1713224 5 4 5 2 2 0 2 1 0 0 0.743 0.940 1.000 427 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 UGDH(1), UGP2(1), UGT1A5(1), UGT1A6(1), UGT1A7(1), UGT1A9(1), UGT2B10(1), UGT2B11(1), UGT2B15(2), UGT2B28(1), UGT2B4(1) 2306988 12 5 12 3 3 0 4 1 4 0 0.550 0.941 1.000 428 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CRADD(1), IKBKB(1), LTA(1), MAP2K4(1), MAP3K1(1), MAP4K2(1) 2059878 6 4 6 3 3 0 0 1 2 0 0.839 0.944 1.000 429 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(3), CCND2(1), DAZL(1), FSHR(1), LHCGR(4), MLH1(1), NRIP1(1), PGR(2), ZP2(1) 2942410 15 6 15 3 3 1 3 4 4 0 0.433 0.945 1.000 430 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 MNAT1(1), XPO1(1) 723888 2 1 2 0 0 0 0 2 0 0 0.618 0.947 1.000 431 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN2A(2), NOS1(1), PPP3CB(1), PRKAR1A(1), PRKAR2A(1) 2176364 7 5 7 2 3 0 2 2 0 0 0.574 0.948 1.000 432 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 MEF2C(1) 651842 1 1 1 0 1 0 0 0 0 0 0.662 0.948 1.000 433 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), CA5B(1), CA8(1) 1794694 3 2 3 2 1 1 1 0 0 0 0.906 0.949 1.000 434 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 EEA1(1), LYN(2), PFKL(1), PFKP(1), PRKCE(1), RAC1(1), VAV2(1) 2127484 8 5 8 3 1 0 3 2 2 0 0.849 0.949 1.000 435 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 MAT2B(1), SEPHS1(1) 1051625 2 1 2 1 1 0 0 0 1 0 0.802 0.950 1.000 436 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CRY1(1), CRY2(1), PER2(1) 1438502 3 2 3 1 1 0 2 0 0 0 0.719 0.953 1.000 437 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH3A1(1), GOT1(1), MPO(1), TPO(1) 1874196 4 4 4 3 1 0 1 0 2 0 0.851 0.955 1.000 438 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 DARS(1), HARS(1), LARS2(1), TARS(1), WARS(1), YARS(3) 2691002 8 5 8 2 2 0 3 2 1 0 0.611 0.956 1.000 439 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 IDH2(1) 751769 1 1 1 0 0 0 1 0 0 0 0.828 0.956 1.000 440 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGA4(2), ITGAL(1), ITGAM(1), ITGB1(1), SELP(2) 1351904 7 2 7 2 1 1 2 3 0 0 0.665 0.958 1.000 441 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), DIAPH2(1), MCM2(1), MCM3(1), MCM5(1), MCM6(1), MCM7(1), NACA(2), POLD2(1), POLE(1), POLE2(1), RFC1(3), RFC4(1), RFC5(2), RPA1(1), RPA4(1), UBC(1) 4280880 22 8 22 7 6 1 7 4 3 1 0.596 0.958 1.000 442 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(1), ACOT12(1), ALDH1B1(1), ALDH3A1(1), HAGHL(1), LDHD(1), ME2(1), PCK1(1) 3959789 8 7 8 2 4 0 3 0 1 0 0.499 0.959 1.000 443 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(1), ATP6AP1(1), ATP6V0A4(1), ATP6V1C1(1), ATP7A(1), ATP7B(1), NDUFA11(1), NDUFB5(1), NDUFV2(1), SDHA(2), UQCRC1(2) 3217313 13 7 13 3 2 0 5 3 3 0 0.396 0.962 1.000 444 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(1), ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), HAGHL(1), LDHD(1), ME2(1), PCK1(1) 3120219 9 6 9 2 5 0 3 0 1 0 0.430 0.962 1.000 445 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 CKM(1), FBL(1), NCL(1) 769448 3 3 3 2 2 0 0 1 0 0 0.833 0.965 1.000 446 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 LYN(2), MAP3K1(1), MAPK8IP3(2), PAPPA(1), RAC1(1), VAV2(1) 2731466 8 6 8 3 1 0 2 3 2 0 0.880 0.969 1.000 447 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(1), CANT1(1), DPYD(1), NME1(1), POLD2(1), POLE(1), POLQ(2), POLR1B(1), POLR2A(2), POLR2B(1), RRM1(1), TK1(1), TK2(1), TYMS(1), UCK2(1), UPB1(1) 4869662 18 9 18 4 4 2 3 5 4 0 0.380 0.969 1.000 448 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(1), CREB5(1), EEF2K(1), MAP3K8(2), RAP1A(1), RPS6KA2(1) 2491926 7 5 7 3 2 1 0 2 2 0 0.785 0.970 1.000 449 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 EGF(2), IKBKB(1), MAP2K4(1), MAP3K1(1), MAP3K5(2), PRKCE(1), PRKCG(1), PRKCQ(1), SP1(1) 4195449 11 7 11 3 3 0 4 1 3 0 0.601 0.970 1.000 450 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(2), CP(2), CPOX(1), HCCS(1), MMAB(1), PPOX(1), UGT1A5(1), UGT1A6(1), UGT1A7(1), UGT1A9(1), UGT2B10(1), UGT2B11(1), UGT2B15(2), UGT2B28(1), UGT2B4(1) 3582433 18 9 18 5 6 1 5 1 5 0 0.526 0.970 1.000 451 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH1B(1), ADH4(1), ADH6(2), ESCO1(1) 2100229 5 2 5 1 1 1 3 0 0 0 0.542 0.971 1.000 452 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 GNAQ(1), MAP2K4(1), MAP3K1(1), RAC1(1) 2413906 4 4 4 5 1 0 1 0 2 0 0.996 0.972 1.000 453 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY6(2), CACNA1A(4), CACNA1B(3), GNAS(2), GNB1(1), GRM4(3), ITPR3(1), KCNB1(2), PDE1A(2), PLCB2(1), PRKX(1), SCNN1A(1), TAS1R3(1), TAS2R3(1), TAS2R50(1), TAS2R9(1) 4891802 27 14 27 5 10 5 4 4 4 0 0.0622 0.973 1.000 454 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1R(1), C2(1), C7(2), C8A(1), C9(1) 1751767 6 3 6 4 1 2 1 0 2 0 0.922 0.975 1.000 455 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 DGKA(2), DGKB(2), DGKI(1), DGKZ(2), INPP4B(1), INPP5A(1), INPP5D(1), INPP5E(1), INPPL1(1), ITPKA(1), ITPKB(2), ITPR1(1), ITPR2(1), ITPR3(1), OCRL(2), PI4KA(2), PI4KB(2), PIK3C2A(1), PIK3C2G(2), PIK3C3(4), PIK3CA(22), PIK3CG(2), PIK3R1(8), PIP4K2A(1), PIP4K2B(1), PIP5K1B(1), PLCB2(1), PLCB3(1), PLCD4(1), PLCE1(2), PRKCG(1), PTEN(15), SYNJ1(2) 10532686 89 36 79 16 13 9 21 20 23 3 0.0380 0.976 1.000 456 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 EP300(1), HDAC2(1), NFATC1(1), NFATC2(1), PPP3CB(1) 2073265 5 3 5 3 2 0 0 2 1 0 0.901 0.977 1.000 457 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ALDH1B1(1), ALDH3A1(1), CNDP1(1), DPYD(1), GAD1(1), SMS(1), SRM(1), UPB1(1) 2291003 8 4 8 2 4 1 0 3 0 0 0.364 0.978 1.000 458 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 PLA2G1B(1) 860882 1 1 1 0 0 0 0 1 0 0 0.828 0.978 1.000 459 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(1), ITGAM(1) 883755 2 1 2 0 0 0 1 1 0 0 0.665 0.980 1.000 460 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(5), CCND1(1), CCND2(1), DVL1(2), DVL3(1), FZD2(1), FZD3(1), MAPK10(1), MAPK9(1), MYC(2), PAFAH1B1(1), PPP2R5E(1), PRKCE(1), PRKCG(1), PRKCQ(1), RAC1(1), SFRP4(1), WNT10A(1), WNT16(1), WNT2B(2), WNT4(1), WNT5B(2) 5159240 30 11 30 6 12 4 3 7 3 1 0.0620 0.980 1.000 461 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 CAMK2B(1), CAMK2D(1), CAMK2G(1), F2(1), GNB1(1), JAK2(2), MYLK(2), STAT1(1), STAT3(2) 3515148 12 9 12 5 5 2 1 2 2 0 0.746 0.981 1.000 462 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2S1(1), EIF5(1) 963627 2 1 2 1 0 0 1 0 1 0 0.838 0.981 1.000 463 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLST(1), IDH2(1), PDK2(1), PDK3(1), SDHA(2), SUCLG1(1) 2401682 7 5 7 3 0 2 3 1 1 0 0.741 0.981 1.000 464 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 ARHGEF11(3), DLG4(1), LPA(1), MAP2K4(1), MAP3K1(1), MAP3K5(2), PHKA2(2), PLD3(1), ROCK2(4) 4155475 16 10 16 5 3 0 4 3 6 0 0.715 0.981 1.000 465 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), C1GALT1C1(1), GALNT12(2), GALNT13(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(1), GALNT9(1), GCNT4(1), OGT(3), WBSCR17(2) 2747162 17 5 17 3 3 1 5 6 2 0 0.294 0.981 1.000 466 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(2), CASP7(1), CASP8(2), CFLAR(1), GAS2(1) 2837242 7 3 7 2 3 0 1 1 2 0 0.524 0.983 1.000 467 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX15B(1), ALOX5(1), CYP2C9(1), CYP2U1(1), CYP4F2(2), CYP4F3(2), GPX6(1), PLA2G1B(1), TBXAS1(2) 3303052 12 7 12 6 4 0 2 4 2 0 0.910 0.983 1.000 468 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(1), ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), ALDH6A1(1), SUCLG1(1) 2799919 7 3 7 3 3 1 1 0 2 0 0.792 0.983 1.000 469 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP4(1), ARHGAP5(3), ARHGAP6(2), ARHGEF11(3), ARHGEF5(2), MYLK(2), OPHN1(3), PIP5K1B(1) 3865735 18 7 18 6 6 1 6 1 4 0 0.548 0.983 1.000 470 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 E2F1(1), HDAC2(1), NCOR2(1), SIN3A(1) 2216065 4 4 4 3 2 0 0 1 1 0 0.832 0.984 1.000 471 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E1(1), GTF2E2(1), GTF2H1(1), GTF2H4(1), TAF1(2), TAF1L(1), TAF4B(1), TAF5(3), TAF7(1), TAF7L(2) 3046623 14 7 14 3 2 1 7 4 0 0 0.495 0.984 1.000 472 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH1B1(1), ALDH3A1(1), ARG1(1), ODC1(1), SMS(1), SRM(1) 2502140 6 4 6 2 3 1 0 2 0 0 0.575 0.985 1.000 473 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 GNAQ(1), MAP2K4(1), MAP3K1(1), MEF2C(1), RAC1(1) 2847213 5 4 5 3 2 0 1 0 2 0 0.943 0.985 1.000 474 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGA4(2), ITGAL(1), ITGB1(1) 1023750 4 2 4 2 0 1 0 3 0 0 0.872 0.986 1.000 475 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), CHRNA1(2), FLT1(1), KDR(2), NOS3(2), PDE2A(1), PDE3A(1), PDE3B(1), PRKAR1A(1), PRKAR2A(1), RYR2(9) 3446714 22 10 22 6 5 0 9 5 2 1 0.520 0.987 1.000 476 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 G6PD(1), GPX6(1), GSR(1), GSTA3(1), IDH2(1) 1891028 5 3 5 3 1 0 2 1 1 0 0.923 0.987 1.000 477 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C7(2), IL1A(1), ITGA4(2), ITGAL(1), ITGB1(1), SELP(2) 2086038 9 3 9 3 1 2 1 4 1 0 0.637 0.988 1.000 478 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT5(1), B3GNT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), FUT1(1), PIGA(3), PIGC(2), PIGF(1), PIGS(1), ST3GAL4(1), ST6GALNAC3(2), ST6GALNAC5(1), UGCG(1) 4110253 18 8 18 6 2 1 7 5 3 0 0.768 0.988 1.000 479 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), EPS15(2), NME1(1), PPP3CB(1), SYNJ1(2) 1859510 8 5 8 3 0 2 2 3 1 0 0.688 0.988 1.000 480 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(1), EGF(2), TF(1) 1082924 4 1 4 2 1 0 2 1 0 0 0.859 0.988 1.000 481 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(2), ITPR1(1), ITPR2(1), ITPR3(1), PHKA2(2), PLD3(1), VN1R1(1) 3829888 13 7 13 3 3 1 4 3 2 0 0.421 0.989 1.000 482 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), IKBKB(1), MAP2K4(1), MAP3K1(1), MYD88(1), TLR10(1), TLR2(2), TLR4(1), TLR6(2), TLR7(1) 3115315 12 6 12 4 1 1 4 3 3 0 0.717 0.990 1.000 483 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), CNDP1(1), HARS(1) 2072775 6 3 6 3 3 0 1 1 1 0 0.783 0.991 1.000 484 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 HSPB1(1), MAP2K4(1), MAP3K1(1), MAP3K5(2), MAP3K9(1), MEF2C(1), MYC(2), RAC1(1), RPS6KA5(1), STAT1(1), TGFB1(1) 3124665 13 9 13 6 4 1 3 3 2 0 0.852 0.991 1.000 485 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), CETP(1), CYP7A1(1), DGAT1(1), HMGCR(1), LRP1(3) 2334823 9 4 9 3 2 1 2 3 0 1 0.585 0.992 1.000 486 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 IDH2(1) 1126565 1 1 1 1 0 0 1 0 0 0 0.938 0.992 1.000 487 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 GTF2E1(1), NCOA1(1), NCOA2(1), NCOR2(1), POLR2A(2) 2118162 6 5 6 4 2 1 1 1 1 0 0.914 0.992 1.000 488 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH3A1(1), ESCO1(1), GOT1(1), MPO(1), TPO(1) 2905560 5 4 5 3 2 0 1 0 2 0 0.803 0.992 1.000 489 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CALR(1), CANX(1), CD74(1), HLA-B(1), HLA-C(1), HLA-DPA1(1), HLA-DQA1(1), HLA-DRA(1), HLA-E(1), IFNA16(1), IFNA2(2), IFNA7(1), KIR3DL1(2), KLRC3(1), LTA(1) 3976174 17 12 17 5 4 2 4 6 1 0 0.401 0.993 1.000 490 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 GNB1(1), MAP3K1(1), NCF1(2), NCF2(1), NFATC1(1), NFATC2(1), PIK3C2G(2), PPP3CB(1), RAC1(1) 3237189 11 7 11 5 4 0 3 2 2 0 0.838 0.993 1.000 491 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACSL1(2), ACSL4(2), ACSL5(1), APOA5(1), CD36(1), CPT1B(1), CYP7A1(1), GK(1), HMGCS2(1), MMP1(2), NR1H3(1), PCK1(1), SCD(1), SCP2(1), SLC27A1(1), SLC27A6(1), UBC(1) 5565026 20 8 20 3 6 1 5 4 4 0 0.0974 0.993 1.000 492 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG1(1), CKM(1), GOT1(1), LAP3(1), NOS1(1), NOS3(2), PYCR2(1) 3057104 10 5 10 4 3 0 3 2 2 0 0.748 0.993 1.000 493 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLD2(1), POLE(1), POLE2(1), POLI(1), POLK(1), POLQ(2), REV1(2), REV3L(5), RFC5(2) 3421042 16 7 16 3 3 1 6 2 4 0 0.341 0.994 1.000 494 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 CCND1(1), CREBBP(6), EP300(1), GTF2E1(1), HDAC2(1), HDAC6(2), MEF2C(1), NCOR2(1), NRIP1(1), PELP1(1), POLR2A(2) 3941537 18 10 18 5 7 3 2 3 3 0 0.368 0.994 1.000 495 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), CNDP1(1), DPYD(1), GAD1(1), SMS(1), UPB1(1) 2464934 9 3 9 3 4 1 0 3 1 0 0.536 0.995 1.000 496 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1B(1), ADH4(1), ADH6(2), ALDH3A1(1), DBH(2), DCT(2), ESCO1(1), GOT1(1), PRMT3(1), TH(1), TPO(1), TYR(1), TYRP1(1) 5029388 16 7 16 3 2 2 6 3 3 0 0.261 0.995 1.000 497 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 BRAF(1), DAG1(1), DRD2(1), EPHB2(2), ITPKA(1), ITPKB(2), ITPR1(1), ITPR2(1), ITPR3(1), KCNJ9(1), PLCB2(1), PLCB3(1), STAT3(2) 4958375 16 9 16 4 4 0 4 4 4 0 0.578 0.995 1.000 498 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(2), ARSE(2), HSD3B2(1), PRMT3(1), SULT2A1(3), UGT1A5(1), UGT1A6(1), UGT1A7(1), UGT1A9(1), UGT2B10(1), UGT2B11(1), UGT2B15(2), UGT2B28(1), UGT2B4(1) 4252931 19 5 19 4 4 0 5 4 6 0 0.414 0.996 1.000 499 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(2), CR1(1), CR2(1), HLA-DRA(1), ITGAL(1) 1293022 6 4 6 3 1 2 1 2 0 0 0.738 0.996 1.000 500 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 PRMT3(1) 1190474 1 1 1 1 0 0 1 0 0 0 0.938 0.996 1.000 501 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(5), DAG1(1), DLG4(1), EPHB2(2), GNAQ(1), ITPR1(1), ITPR2(1), ITPR3(1), KCNJ9(1), RAC1(1), RYR1(1) 3910994 16 5 16 4 5 1 2 5 2 1 0.330 0.996 1.000 502 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(2), BCL2L1(1), CASP4(1), CASP7(1), CASP8(2), CD40LG(1), CRADD(1), LTA(1), NTRK1(2), PTPN13(1) 3658846 13 6 13 6 5 2 1 3 2 0 0.740 0.996 1.000 503 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACADS(1), ACSL1(2), ACSL4(2), ACSL5(1), ADH1B(1), ADH4(1), ADH6(2), ALDH1B1(1), ALDH3A1(1), CPT1B(1) 4142870 13 4 13 2 3 1 4 2 3 0 0.179 0.996 1.000 504 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 LYN(2), MAP3K1(1), NFATC1(1), NFATC2(1), PPP3CB(1), RAC1(1) 3257715 7 4 7 6 2 0 1 3 1 0 0.984 0.997 1.000 505 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 ESCO1(1) 1398481 1 1 1 0 1 0 0 0 0 0 0.689 0.997 1.000 506 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(2), CREBBP(6), CTBP2(2), DTX3L(1), DTX4(2), DVL1(2), DVL3(1), EP300(1), HDAC2(1), JAG1(1), MAML1(1), MAML2(2), NCOR2(1), NOTCH1(2), NOTCH3(1), NOTCH4(1), PSEN1(1), PTCRA(1) 5980692 29 16 29 7 12 7 0 5 5 0 0.141 0.997 1.000 507 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 PRMT3(1) 1266545 1 1 1 0 0 0 1 0 0 0 0.809 0.997 1.000 508 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTR3(1), FLNA(7), FSCN3(3), MYH2(2), MYLK(2), PAK4(2), PFN2(1), ROCK2(4), WASF1(1), WASL(1) 4097320 24 10 24 9 8 1 7 2 6 0 0.617 0.997 1.000 509 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(1), CANT1(1), DPYD(1), NME1(1), NT5C1A(1), NT5C1B(1), PNPT1(1), POLD2(1), POLE(1), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), RFC5(2), RRM1(1), TK1(1), TK2(1), TYMS(1), UCK2(1), UPB1(1) 6854152 24 11 24 5 7 3 3 6 5 0 0.198 0.997 1.000 510 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(1), ALDH1B1(1), ALDH3A1(1), ALDH6A1(1), SUCLG1(1) 3360450 5 3 5 3 2 1 1 0 1 0 0.872 0.998 1.000 511 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(1), CACNA1A(4), CRHR1(1), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(2), GRIA1(2), GRIA3(5), GRID2(1), GRM1(2), GRM5(1), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(7), LYN(2), NOS1(1), NOS3(2), NPR1(1), NRAS(1), PLA2G1B(1), PLCB2(1), PLCB3(1), PPP2R1A(17), PPP2R2B(1), PRKCG(1), RYR1(1) 9402376 63 25 51 12 18 11 19 6 9 0 0.0187 0.998 1.000 512 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACSL1(2), ACSL4(2), ACSL5(1), ADIPOR1(1), CD36(1), CPT1B(1), IKBKB(1), IRS1(2), IRS4(1), JAK2(2), JAK3(3), LEPR(1), MAPK10(1), MAPK9(1), NPY(1), PCK1(1), POMC(1), PRKCQ(1), PTPN11(1), SLC2A4(1), STAT3(2) 7076589 28 10 28 9 6 4 3 7 8 0 0.378 0.998 1.000 513 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(2), NR1H3(1), NR4A1(1), PGR(2), RARG(1) 3625155 7 7 7 9 3 2 0 1 1 0 0.996 0.998 1.000 514 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ARG1(1), CKM(1), ODC1(1), SMS(1) 1488015 4 2 4 2 1 1 0 2 0 0 0.803 0.999 1.000 515 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(1), ACTR3(1), ARHGEF6(2), BRAF(1), CDKN2A(1), DOCK1(1), EPHB2(2), ITGA1(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA3(1), ITGA4(2), ITGA7(1), ITGA8(1), ITGA9(2), MAP2K4(1), MAPK10(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(1), MYLK(2), PAK4(2), PIK3CA(22), PTEN(15), ROCK2(4), TLN2(2), WAS(3) 10378874 79 33 69 15 14 11 16 23 14 1 0.0281 0.999 1.000 516 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS2(1), DARS(1), DARS2(2), FARSB(2), HARS(1), IARS2(1), LARS2(1), MTFMT(1), TARS(1), VARS2(1), WARS(1), YARS(3), YARS2(1) 4596767 17 10 17 5 3 1 3 6 4 0 0.732 0.999 1.000 517 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 164 ADRA1B(1), ADRA2A(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(2), CCR3(2), CCR6(1), CCR8(1), CHRM2(2), CHRM3(1), CHRM5(1), CMKLR1(2), CNR1(2), CNR2(1), CX3CR1(1), DRD2(1), DRD3(1), EDNRB(1), F2RL1(2), FSHR(1), GALR1(1), GPR37(3), GPR63(2), GPR85(1), GRPR(1), HCRTR2(4), HTR1B(2), HTR1E(1), HTR4(1), HTR5A(1), LHCGR(4), MC1R(1), MC3R(2), MTNR1A(1), NPY5R(1), NTSR1(2), OPN1SW(1), OPRD1(1), OPRL1(1), OR12D3(1), OR1C1(2), OR7C1(1), OXTR(1), P2RY10(3), P2RY12(1), SSTR4(1), TRHR(2) 10476617 70 24 70 16 18 10 18 17 7 0 0.0285 0.999 1.000 518 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 G6PD(1), GSTA3(1), IDH2(1) 1529650 3 3 3 2 0 0 2 1 0 0 0.894 0.999 1.000 519 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACPP(1), CYP3A43(1) 1539224 2 1 2 0 0 0 1 1 0 0 0.657 0.999 1.000 520 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(2), ABCA12(5), ABCA13(3), ABCA2(1), ABCA3(1), ABCA4(2), ABCA5(3), ABCA6(2), ABCA7(2), ABCA8(2), ABCA9(2), ABCB1(3), ABCB11(2), ABCB4(2), ABCB5(1), ABCB6(1), ABCB7(2), ABCB8(1), ABCB9(1), ABCC1(2), ABCC10(2), ABCC12(1), ABCC2(4), ABCC4(1), ABCC8(1), ABCC9(1), ABCD2(2), ABCG2(1), ABCG8(2), CFTR(1) 9967943 56 18 56 13 14 7 14 15 4 2 0.104 0.999 1.000 521 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(3), CDR1(1), DGKI(1), IL6ST(1), MRPL19(1), RPL34(1), RPL38(1), RPS2(1), RPS28(1), RPS6KA2(1), RPS6KA6(2), RPS7(1), RPSA(1), SLC36A2(1), TSPAN9(1), UBC(1) 4411918 19 7 19 7 6 4 3 4 2 0 0.628 0.999 1.000 522 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 GOT1(1), ME2(1) 1543471 2 1 2 1 1 0 0 0 1 0 0.808 0.999 1.000 523 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(2), ALDH5A1(1), CAD(1), GAD1(1), GFPT1(1), GMPS(2), GOT1(1), GSR(1), NADSYN1(1) 3354941 11 5 11 3 2 1 3 3 2 0 0.652 0.999 1.000 524 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), DLST(1), EHMT1(1), TMLHE(1) 3136411 7 4 7 3 4 1 0 1 1 0 0.644 0.999 1.000 525 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1B(1), ADH4(1), ADH6(2), ALDH3A1(1), CYP1A1(1), CYP1A2(2), CYP2C9(1), CYP2F1(1), CYP2S1(1), CYP3A43(1), GSTA3(1), UGT1A5(1), UGT1A6(1), UGT1A7(1), UGT1A9(1), UGT2B10(1), UGT2B11(1), UGT2B15(2), UGT2B28(1), UGT2B4(1) 4863545 23 10 23 9 4 3 9 3 4 0 0.772 0.999 1.000 526 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN2(1), ITGA1(2), ITGB1(1), PXN(1), RAP1A(1) 4002759 7 6 7 4 1 2 1 2 1 0 0.827 0.999 1.000 527 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY2(4), ADCY3(1), ADCY6(2), ADCY7(1), ADCY9(1), CACNA1C(2), CACNA1D(2), CACNA1F(2), CACNA1S(1), CAMK2B(1), CAMK2D(1), CAMK2G(1), GNAQ(1), GNAS(2), GNRHR(1), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(7), MAP2K4(1), MAP3K1(1), MAP3K4(4), MAPK10(1), MAPK7(1), MAPK9(1), MMP2(1), NRAS(1), PLA2G1B(1), PLCB2(1), PLCB3(1), PRKX(1) 10896190 48 22 43 9 10 6 11 8 13 0 0.0907 0.999 1.000 528 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK2B(1), CAMK2D(1), CAMK2G(1), MEF2C(1), PPP3CB(1), SLC2A4(1) 1715962 6 3 6 3 3 1 1 1 0 0 0.729 0.999 1.000 529 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN2(1), CTNNA2(2), PXN(1) 1644527 4 3 4 2 2 0 1 1 0 0 0.773 0.999 1.000 530 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 ENPP1(1), ENPP3(1), NADSYN1(1), NT5C1A(1), NT5C1B(1) 1830783 5 2 5 2 3 0 1 1 0 0 0.693 1.000 1.000 531 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(1), BMPR2(1), COL4A3BP(1), CSNK2B(1), DGKA(2), DGKB(2), DGKZ(2), INPP4B(1), INPP5A(1), INPPL1(1), ITPKA(1), ITPKB(2), OCRL(2), PAK4(2), PIK3C2A(1), PIK3C2G(2), PIK3CA(22), PIK3CG(2), PLCB2(1), PLCB3(1), PLK3(1), PRKAR1A(1), PRKAR2A(1), PRKCE(1), PRKCG(1), PRKCQ(1), RPS6KA2(1) 9546753 57 28 48 12 10 6 17 16 7 1 0.135 1.000 1.000 532 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 GOT1(1) 1724527 1 1 1 1 0 0 0 0 1 0 0.935 1.000 1.000 533 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), ALDH4A1(2), ARG1(1), CKM(1), GOT1(1), NOS1(1), NOS3(2), ODC1(1), SMS(1) 3760186 14 6 14 6 5 1 3 2 3 0 0.738 1.000 1.000 534 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(1), ACTN2(1), ACTN4(1), CLDN19(1), CLDN20(1), CLDN4(1), CLDN5(1), CSNK2B(1), CTNNA2(2), EPB41L2(3), EPB41L3(1), EXOC4(1), GNAI2(1), GNAI3(1), HCLS1(1), IGSF5(1), INADL(4), KRAS(7), MAGI2(2), MLLT4(1), MPP5(1), MYH1(2), MYH10(1), MYH11(1), MYH13(1), MYH2(2), MYH6(1), MYH7(2), MYH7B(1), MYH9(3), NRAS(1), OCLN(1), PARD3(1), PPP2R1A(17), PPP2R2B(1), PRKCE(1), PRKCG(1), PRKCQ(1), PTEN(15), RRAS2(1), SYMPK(2), TJP1(1), YES1(1), ZAK(1) 16495945 93 37 80 16 31 11 29 7 14 1 0.00254 1.000 1.000 535 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(1), GABBR1(1), GPRC5A(1), GRM1(2), GRM3(1), GRM4(3), GRM5(1), GRM7(3), GRM8(2) 1785120 15 8 15 8 6 2 4 2 1 0 0.762 1.000 1.000 536 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CAMK2B(1), CD3E(1), CNR1(2), CREBBP(6), CSNK2B(1), EP300(1), FCER1A(1), GATA3(1), GATA4(1), IL1B(2), IL2(1), IL2RA(1), ITK(1), MAPK9(1), NFAT5(2), NFATC1(1), NFATC2(1), OPRD1(1), PPP3CB(1), SP1(1), TGFB1(1), VAV2(1), XPO5(1) 7765388 32 15 32 6 12 4 6 5 5 0 0.0824 1.000 1.000 537 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM17(2), ATP6AP1(1), ATP6V0A2(1), ATP6V0A4(1), ATP6V0D2(2), ATP6V1C1(1), IGSF5(1), IKBKB(1), LYN(2), MAP2K4(1), MAPK10(1), MAPK9(1), MET(2), PTPN11(1), PTPRZ1(3), RAC1(1), TJP1(1) 5945979 23 7 23 7 5 0 6 8 4 0 0.578 1.000 1.000 538 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), DDHD1(1), ESCO1(1), PLA1A(1) 2134826 4 1 4 0 1 0 1 1 1 0 0.289 1.000 1.000 539 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY2(4), ADCY3(1), ADCY6(2), ADCY7(1), ADCY9(1), CAMK2B(1), CAMK2D(1), CAMK2G(1), CREBBP(6), DCT(2), DVL1(2), DVL3(1), EDNRB(1), EP300(1), FZD2(1), FZD3(1), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(2), KIT(2), KITLG(1), KRAS(7), MC1R(1), NRAS(1), PLCB2(1), PLCB3(1), POMC(1), PRKCG(1), PRKX(1), TCF7L2(1), TYR(1), TYRP1(1), WNT10A(1), WNT16(1), WNT2B(2), WNT4(1), WNT5B(2), WNT8B(1), WNT9B(2) 9373866 62 24 57 12 17 11 12 14 8 0 0.0242 1.000 1.000 540 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ESCO1(1) 2199234 1 1 1 1 1 0 0 0 0 0 0.898 1.000 1.000 541 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 MAT2B(1), PRMT3(1), SEPHS1(1) 2112270 3 1 3 1 1 0 1 0 1 0 0.714 1.000 1.000 542 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ALDH1A1(2), ALDH1B1(1), ALDH3A1(1), CYP1A1(1), CYP1A2(2), CYP2A7(2), CYP2C9(1), CYP2F1(1), CYP4B1(2), CYP51A1(1), KYNU(2), WARS(1) 4669772 17 9 17 6 7 3 2 3 2 0 0.572 1.000 1.000 543 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), CASP8(2), CFLAR(1), MAP2K4(1), TNFAIP3(1) 2331015 6 3 6 3 2 0 1 1 2 0 0.827 1.000 1.000 544 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(1), BDKRB1(1), C1R(1), C2(1), C3AR1(1), C4BPA(1), C7(2), C8A(1), C9(1), CD55(1), CR1(1), CR2(1), F10(1), F12(1), F13A1(1), F13B(1), F2(1), F5(1), F8(4), F9(2), FGA(1), FGB(2), FGG(2), KLKB1(3), KNG1(1), PROS1(3), SERPINC1(2), TFPI(2), VWF(2) 7670008 43 14 43 14 7 6 5 12 13 0 0.506 1.000 1.000 545 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1B1(1), ALDH3A1(1), CYP2C9(1), ESCO1(1) 2621280 4 3 4 2 3 0 0 1 0 0 0.726 1.000 1.000 546 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 CLYBL(1), DLST(1), IDH2(1), OGDHL(4), PCK1(1), SDHA(2), SUCLG1(1) 2532609 11 6 11 4 3 3 3 1 1 0 0.540 1.000 1.000 547 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ALDH1B1(1), ALDH3A1(1), CYP1A1(1), CYP1A2(2), KYNU(2), NFX1(1), OGDHL(4), PRMT3(1), TPH2(1), WARS(1) 5141502 15 9 15 6 7 4 2 1 1 0 0.525 1.000 1.000 548 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH2L(2), CTCFL(2), EHMT1(1), EZH2(1), HCFC1(3), JMJD4(1), KDM6A(1), MEN1(1), NSD1(5), OGT(3), PPP1CB(1), PRDM2(1), PRDM7(1), PRDM9(1), SATB1(1), SETD1A(2), SETD2(1), SETDB1(3), SUV39H1(1), SUV420H1(2) 10171539 34 17 34 6 10 4 5 10 5 0 0.101 1.000 1.000 549 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY2(4), ADCY3(1), ADCY6(2), ADCY7(1), ADCY9(1), DRD2(1), EGF(2), GJA1(1), GJD2(1), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(2), GRM1(2), GRM5(1), ITPR1(1), ITPR2(1), ITPR3(1), KRAS(7), MAPK7(1), NPR1(1), NRAS(1), PDGFRB(4), PLCB2(1), PLCB3(1), PRKCG(1), PRKX(1), TJP1(1), TUBA3C(2), TUBA3D(1), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2B(1) 11254287 52 20 47 11 15 8 16 5 8 0 0.0851 1.000 1.000 550 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(1), ACTN2(1), ACTN4(1), ACVR1B(1), CREBBP(6), CSNK2B(1), CTNNA2(2), CTNND1(1), EP300(1), ERBB2(1), FARP2(1), FER(2), INSR(1), IQGAP1(1), MET(2), MLLT4(1), NLK(1), PARD3(1), PTPN6(1), PTPRB(1), PTPRF(1), PTPRM(4), PVRL2(1), RAC1(1), RAC3(1), SMAD4(1), TCF7L2(1), TJP1(1), WAS(3), WASF1(1), WASF3(1), WASL(1), YES1(1) 10174058 46 20 45 12 10 3 10 8 15 0 0.383 1.000 1.000 551 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1B1(1), ALDH3A1(1), CNDP1(1), HARS(1), PRMT3(1) 3357903 5 3 5 2 2 0 2 1 0 0 0.668 1.000 1.000 552 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(1), ACVR1B(1), BMPR2(1), CCL1(1), CCL13(1), CCR3(2), CCR6(1), CCR8(1), CD40LG(1), CSF2RA(2), CSF2RB(1), CX3CR1(1), EDAR(2), EGF(2), FLT1(1), FLT3(1), FLT3LG(1), HGF(1), IFNA16(1), IFNA2(2), IFNA7(1), IFNW1(2), IL12A(1), IL13RA1(1), IL1A(1), IL1B(2), IL1R1(1), IL1R2(2), IL1RAP(1), IL2(1), IL21(1), IL2RA(1), IL3RA(1), IL5RA(1), IL6ST(1), INHBA(1), KDR(2), KIT(2), KITLG(1), LEPR(1), LTA(1), MET(2), PDGFRB(4), TGFB1(1), TNFRSF11A(1), TNFRSF11B(1), TNFRSF14(1), TNFRSF21(1), TNFRSF6B(2), TNFSF18(1), TPO(1), XCL2(1) 15086187 67 26 67 19 14 7 23 17 6 0 0.233 1.000 1.000 553 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AGXT2(1), ALAS2(2), CPT1B(1), PLCB2(1), SARDH(1), TARS(1) 3551315 8 4 8 3 4 1 2 0 1 0 0.594 1.000 1.000 554 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AGXT2(1), ALAS2(2), RDH14(2), SARDH(1), TARS(1) 3623312 8 5 8 3 4 1 1 1 1 0 0.649 1.000 1.000 555 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTN2(1), ACTN4(1), DMD(4), MYBPC1(2), MYBPC2(3), MYBPC3(1), MYH6(1), MYH7(2), MYOM1(1), NEB(4), TNNI3(1), TNNT1(2), TTN(32) 11499516 56 21 56 16 15 8 15 10 7 1 0.386 1.000 1.000 556 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(3), CD226(1), CD34(1), CD40LG(1), CD80(2), CD86(1), CDH2(1), CDH4(1), CLDN19(1), CLDN20(1), CLDN4(1), CLDN5(1), CNTN2(1), HLA-B(1), HLA-C(1), HLA-DPA1(1), HLA-DQA1(1), HLA-DRA(1), HLA-E(1), ICOSLG(1), ITGA4(2), ITGA8(1), ITGA9(2), ITGAL(1), ITGAM(1), ITGAV(1), ITGB1(1), ITGB8(1), L1CAM(3), MAG(2), NCAM1(1), NCAM2(1), NEO1(2), NLGN1(1), NRCAM(1), NRXN1(5), NRXN2(2), OCLN(1), PDCD1(1), PTPRF(1), PTPRM(4), PVRL2(1), SELP(2), SIGLEC1(1), VCAN(3) 12610586 65 25 65 22 14 7 13 22 9 0 0.546 1.000 1.000 557 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(1), BDNF(1), BRAF(1), CACNA1A(4), CACNA1B(3), CACNA1C(2), CACNA1D(2), CACNA1E(5), CACNA1F(2), CACNA1H(4), CACNA1I(1), CACNA1S(1), CACNA2D1(3), CACNA2D3(3), CACNB2(1), CACNB4(3), CACNG3(1), CACNG7(1), CD14(1), DUSP16(1), DUSP5(1), ECSIT(1), EGF(2), FGF12(1), FGF13(1), FGF14(2), FGF6(1), FGF7(1), FGFR2(2), FLNA(7), IKBKB(1), IL1A(1), IL1B(2), IL1R1(1), IL1R2(2), KRAS(7), MAP2K4(1), MAP3K1(1), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K8(2), MAP4K2(1), MAP4K3(1), MAPK10(1), MAPK7(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(1), MEF2C(1), MYC(2), NF1(4), NFATC2(1), NLK(1), NR4A1(1), NRAS(1), NTF3(1), NTRK1(2), PDGFRB(4), PLA2G1B(1), PPP3CB(1), PRKCG(1), PRKX(1), PTPN5(1), PTPRR(1), RAC1(1), RAC3(1), RAP1A(1), RASA1(1), RASGRF1(1), RASGRF2(2), RASGRP1(1), RASGRP4(1), RPS6KA2(1), RPS6KA5(1), RPS6KA6(2), RRAS2(1), STK3(1), STK4(1), TGFB1(1), TP53(55), ZAK(1) 24437614 191 57 174 33 47 20 46 41 36 1 0.000130 1.000 1.000 558 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(1), ARHGEF12(1), DCC(8), EFNA5(1), EFNB2(1), EFNB3(1), EPHA1(1), EPHA2(1), EPHA3(3), EPHA4(1), EPHA5(5), EPHA6(1), EPHB1(2), EPHB2(2), EPHB4(1), GNAI2(1), GNAI3(1), ITGB1(1), KRAS(7), L1CAM(3), LRRC4C(1), MET(2), NCK1(2), NFAT5(2), NFATC1(1), NFATC2(1), NGEF(1), NRAS(1), PAK4(2), PLXNA1(1), PLXNA2(2), PLXNA3(2), PLXNB2(3), PLXNB3(1), PLXNC1(3), PPP3CB(1), RAC1(1), RAC3(1), RASA1(1), RGS3(1), ROBO1(1), ROBO2(3), ROBO3(1), ROCK2(4), SEMA3A(1), SEMA3E(2), SEMA3G(1), SEMA5A(3), SEMA5B(1), SEMA6A(2), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT2(1), UNC5D(2) 16814598 100 31 95 20 23 18 30 17 12 0 0.00892 1.000 1.000 559 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY2(4), ADCY3(1), ADCY6(2), ADCY7(1), ADCY9(1), ADRA1B(1), ANXA6(1), ATP1B2(1), ATP1B3(1), ATP2B1(1), ATP2B2(1), ATP2B3(1), CACNA1A(4), CACNA1B(3), CACNA1C(2), CACNA1D(2), CACNA1E(5), CACNA1S(1), CALR(1), CAMK2B(1), CAMK2D(1), CAMK2G(1), CASQ1(1), CHRM2(2), CHRM3(1), CHRM5(1), GJA1(1), GJB3(1), GNAI2(1), GNAI3(1), GNAQ(1), GNB1(1), GNB5(1), GRK4(1), ITPR1(1), ITPR2(1), ITPR3(1), KCNB1(2), PLCB3(1), PRKAR1A(1), PRKAR2A(1), PRKCE(1), PRKCG(1), PRKCQ(1), RGS14(2), RGS3(1), RGS7(2), RYR1(1), RYR2(9), RYR3(6), SLC8A1(2), SLC8A3(2) 15960063 86 27 86 27 29 10 19 12 15 1 0.228 1.000 1.000 560 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 ACTN2(1), ACTN4(1), APC(5), ARAF(1), ARHGEF12(1), ARHGEF6(2), BDKRB1(1), BRAF(1), CD14(1), CHRM2(2), CHRM3(1), CHRM5(1), CYFIP1(1), CYFIP2(3), DIAPH2(1), DOCK1(1), EGF(2), EZR(1), F2(1), FGF12(1), FGF13(1), FGF14(2), FGF6(1), FGF7(1), FGFR2(2), FN1(1), IQGAP1(1), IQGAP2(3), ITGA1(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA7(1), ITGA8(1), ITGA9(2), ITGAL(1), ITGAM(1), ITGAV(1), ITGAX(1), ITGB1(1), ITGB4(1), ITGB8(1), KRAS(7), MYH10(1), MYH9(3), MYLK(2), NCKAP1(3), NCKAP1L(1), NRAS(1), PAK4(2), PDGFRB(4), PFN2(1), PIK3CA(22), PIK3CG(2), PIK3R1(8), PIP4K2A(1), PIP4K2B(1), PIP5K1B(1), PPP1CB(1), PXN(1), RAC1(1), RAC3(1), ROCK2(4), RRAS2(1), SSH2(2), TIAM1(2), TIAM2(2), VAV2(1), WAS(3), WASF1(1), WASL(1) 23518755 143 46 129 31 24 23 33 38 24 1 0.0256 1.000 1.000 561 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(2), CD36(1), COL11A1(4), COL11A2(1), COL1A2(1), COL3A1(1), COL4A1(2), COL4A2(1), COL4A4(1), COL4A6(1), COL5A1(1), COL5A3(1), COL6A2(1), COL6A3(2), COL6A6(3), DAG1(1), FN1(1), FNDC1(2), FNDC3A(2), FNDC4(1), FNDC5(1), HMMR(2), HSPG2(1), ITGA1(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA7(1), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB4(1), ITGB8(1), LAMA1(1), LAMA2(1), LAMA3(2), LAMA4(1), LAMA5(3), LAMB1(1), LAMB2(2), LAMB3(2), LAMC1(2), LAMC3(1), RELN(1), SV2B(2), THBS2(1), TNC(1), TNXB(3), VTN(1), VWF(2) 19213951 79 26 79 23 16 10 19 21 13 0 0.304 1.000 1.000 562 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(1), ACTN2(1), ACTN4(1), ARHGAP5(3), BRAF(1), CAV2(1), CCND1(1), CCND2(1), COL11A1(4), COL11A2(1), COL1A2(1), COL3A1(1), COL4A1(2), COL4A2(1), COL4A4(1), COL4A6(1), COL5A1(1), COL5A3(1), COL6A2(1), COL6A3(2), COL6A6(3), DOCK1(1), EGF(2), ERBB2(1), FARP2(1), FLNA(7), FLT1(1), FN1(1), HGF(1), ITGA1(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA7(1), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB4(1), ITGB8(1), KDR(2), LAMA1(1), LAMA2(1), LAMA3(2), LAMA4(1), LAMA5(3), LAMB1(1), LAMB2(2), LAMB3(2), LAMC1(2), LAMC3(1), MAPK10(1), MAPK9(1), MET(2), MYLK(2), PAK4(2), PDGFRB(4), PIK3CA(22), PIK3CG(2), PIK3R1(8), PPP1CB(1), PRKCG(1), PTEN(15), PXN(1), RAC1(1), RAC3(1), RAP1A(1), RELN(1), ROCK2(4), THBS2(1), TLN2(2), TNC(1), TNXB(3), VAV2(1), VTN(1), VWF(2) 31635732 162 48 152 39 34 22 42 35 28 1 0.0488 1.000 1.000 563 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADRA1B(1), ADRA2A(1), ADRA2B(1), BDKRB1(1), BRS3(1), C3AR1(1), CALCR(1), CCKAR(2), CHRM2(2), CHRM3(1), CHRM5(1), CNR1(2), CNR2(1), CRHR1(1), CYSLTR1(1), CYSLTR2(1), DRD2(1), DRD3(1), EDNRB(1), F2(1), F2RL1(2), FSHR(1), GABBR1(1), GABBR2(1), GABRA1(1), GABRA3(1), GABRA4(2), GABRA6(1), GABRB2(3), GABRB3(1), GABRE(1), GABRG2(1), GABRR2(1), GALR1(1), GLP2R(1), GLRA1(1), GLRA3(2), GNRHR(1), GPR63(2), GRIA1(2), GRIA3(5), GRID1(1), GRID2(1), GRIK2(1), GRIK3(1), GRIK4(1), GRIN2A(2), GRM1(2), GRM3(1), GRM4(3), GRM5(1), GRM6(3), GRM7(3), GRM8(2), GRPR(1), HCRTR2(4), HTR1B(2), HTR1E(1), HTR4(1), HTR5A(1), LEPR(1), LHCGR(4), MC1R(1), MC2R(1), MC3R(2), MCHR2(1), MTNR1A(1), NPY5R(1), NTSR1(2), OPRD1(1), OPRL1(1), OXTR(1), P2RX2(1), P2RY10(3), PARD3(1), RXFP1(2), RXFP2(1), SSTR4(1), SSTR5(1), TACR1(1), TRHR(2), TSHR(2) 18951328 119 33 119 42 32 12 39 20 16 0 0.353 1.000 1.000 564 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 169 ADCY2(4), ADCY3(1), ADCY7(1), ADCY9(1), ADRA1B(1), ATP2B1(1), ATP2B2(1), ATP2B3(1), ATP2B4(1), BDKRB1(1), CACNA1A(4), CACNA1B(3), CACNA1C(2), CACNA1D(2), CACNA1E(5), CACNA1F(2), CACNA1H(4), CACNA1I(1), CACNA1S(1), CAMK2B(1), CAMK2D(1), CAMK2G(1), CCKAR(2), CHRM2(2), CHRM3(1), CHRM5(1), CYSLTR1(1), CYSLTR2(1), EDNRB(1), ERBB2(1), ERBB3(5), ERBB4(1), GNAQ(1), GNAS(2), GRIN2A(2), GRM1(2), GRM5(1), GRPR(1), HTR4(1), HTR5A(1), ITPKA(1), ITPKB(2), ITPR1(1), ITPR2(1), ITPR3(1), LHCGR(4), MYLK(2), NOS1(1), NOS3(2), NTSR1(2), OXTR(1), P2RX2(1), PDE1A(2), PDE1B(2), PDE1C(1), PDGFRB(4), PHKA1(1), PHKA2(2), PLCB2(1), PLCB3(1), PLCD4(1), PLCE1(2), PPP3CB(1), PRKCG(1), PRKX(1), RYR1(1), RYR2(9), RYR3(6), SLC25A5(1), SLC25A6(1), SLC8A1(2), SLC8A3(2), TACR1(1), TRHR(2), TRPC1(2) 23060608 133 31 133 36 40 12 34 24 22 1 0.0534 1.000 1.000 565 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), COL11A1(4), COL11A2(1), COL17A1(1), COL1A2(1), COL3A1(1), COL4A1(2), COL4A2(1), COL4A4(1), COL4A6(1), COL5A1(1), COL5A3(1), COL6A2(1), COL6A3(2), COL6A6(3), DSC1(2), DSC3(1), DSG4(2), FN1(1), GJA1(1), GJA3(1), GJA8(1), GJB3(1), GJC1(1), GJD2(1), INA(1), ITGB4(1), KRT18(1), KRT37(1), KRT4(1), KRT6A(1), KRT6B(1), KRT6C(2), KRT72(1), KRT76(3), KRT9(1), LAMA1(1), LAMA2(1), LAMA3(2), LAMA4(1), LAMA5(3), LAMB1(1), LAMB2(2), LAMB3(2), LAMC1(2), LAMC3(1), NES(1), RELN(1), THBS2(1), TNC(1), TNXB(3), VTN(1), VWF(2) 21370092 74 26 74 29 23 6 25 13 7 0 0.747 1.000 1.000 566 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY2(4), ADCY3(1), ADCY6(2), ADCY7(1), ADCY9(1), ATF3(1), ATF5(1), CAMK2B(1), CAMK2D(1), CAMK2G(1), CORIN(2), CRHR1(1), DGKZ(2), GJA1(1), GNAQ(1), GNB1(1), GNB5(1), GRK4(1), IGFBP1(1), IL1B(2), ITPR1(1), ITPR2(1), ITPR3(1), NOS1(1), NOS3(2), OXTR(1), PDE4D(2), PLCB3(1), PRKAR1A(1), PRKAR2A(1), PRKCE(1), PRKCQ(1), RGS14(2), RGS3(1), RGS7(2), RYR1(1), RYR2(9), RYR3(6), SLC8A1(2), SP1(1), TNXB(3) 14737362 69 23 69 25 22 5 17 11 13 1 0.565 1.000 1.000 567 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CPSF2(1), CSTF2(1), DHX8(1), DHX9(3), DICER1(2), NCBP1(1), NONO(1), POLR2A(2), PRPF4(1), PRPF4B(1), PRPF8(4), RBM17(1), SF3B1(1), SNRPA(1), SPOP(5), SRPK2(1), SRRM1(1), SUPT5H(2), U2AF1(2) 8998514 33 18 32 13 5 9 5 11 3 0 0.804 1.000 1.000 568 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY2(4), ADCY3(1), ADCY6(2), ADCY7(1), ADCY9(1), AK5(1), ALLC(2), AMPD2(1), CANT1(1), ENPP1(1), ENPP3(1), GART(2), GMPS(2), NME1(1), NPR1(1), NT5C1A(1), NT5C1B(1), NUDT5(1), PDE11A(2), PDE1A(2), PDE1C(1), PDE2A(1), PDE3B(1), PDE4D(2), PDE8B(1), PDE9A(1), PFAS(1), PNPT1(1), POLD2(1), POLE(1), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), RFC5(2), RRM1(1), XDH(1) 13835264 51 16 51 11 15 5 12 12 7 0 0.100 1.000 1.000 569 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 109 A4GNT(1), ALG1(1), ALG10B(2), ALG12(1), ALG13(2), ALG6(1), B3GNT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), C1GALT1(1), C1GALT1C1(1), CHST11(1), CHST12(1), CHST3(1), GALNT12(2), GALNT13(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(1), GALNT9(1), GCNT4(1), HS3ST3A1(1), MAN1A2(1), MAN1B1(2), MAN1C1(1), MAN2A1(2), MGAT4A(2), MGAT5(1), NDST4(1), OGT(3), RPN2(1), ST3GAL4(1), UST(1), WBSCR17(2), XYLT1(1), XYLT2(1) 9469907 48 16 47 18 10 2 17 12 6 1 0.719 1.000 1.000 570 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 CD14(1), CD19(1), CD1B(1), CD1D(1), CD1E(1), CD34(1), CD36(1), CD37(1), CD3E(1), CD55(1), CR1(1), CR2(1), CSF2RA(2), FLT3(1), FLT3LG(1), HLA-DRA(1), IL1A(1), IL1B(2), IL1R1(1), IL1R2(2), IL2RA(1), IL3RA(1), IL5RA(1), ITGA1(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(2), ITGAM(1), KIT(2), KITLG(1), TPO(1) 6932553 38 16 38 15 5 8 9 11 5 0 0.656 1.000 1.000 571 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 CAPN11(1), CAPN3(1), CAPN6(1), CAPN7(1), CAPN9(3), CAV2(1), DOCK1(1), GIT2(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA7(1), ITGA8(1), ITGA9(2), ITGAL(1), ITGAM(1), ITGAV(1), ITGAX(1), ITGB1(1), ITGB4(1), ITGB8(1), MAPK10(1), MAPK4(1), MAPK6(1), MAPK7(1), PAK4(2), PXN(1), RAC1(1), RAC3(1), ROCK2(4), VAV2(1) 11395175 43 14 43 16 3 5 11 15 9 0 0.749 1.000 1.000 572 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(1), IKBKB(1), MAP2K4(1), MAP3K1(1), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K8(2), MAP3K9(1), MAP4K2(1), MAP4K3(1), MAPK10(1), MAPK4(1), MAPK6(1), MAPK7(1), MAPK9(1), MEF2C(1), MYC(2), RAC1(1), RPS6KA2(1), RPS6KA5(1), SP1(1), STAT1(1), TGFB1(1) 8124332 30 14 30 11 9 0 5 10 6 0 0.794 1.000 1.000 573 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY2(4), ADCY3(1), ADCY6(2), ADCY7(1), AK5(1), ALLC(2), AMPD2(1), ATP5B(1), ATP5H(1), CANT1(1), ENPP1(1), ENPP3(1), GART(2), GMPS(2), NME1(1), NPR1(1), PDE1A(2), PDE4D(2), PDE6B(1), PDE9A(1), PFAS(1), POLD2(1), POLE(1), POLQ(2), POLR1B(1), POLR2A(2), POLR2B(1), RRM1(1) 10880829 39 14 39 10 11 3 8 12 5 0 0.318 1.000 1.000 574 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT1(1), CHST11(1), CHST12(1), CHST3(1), DSE(1), UST(1), XYLT1(1), XYLT2(1) 1251795 8 6 8 5 4 0 3 1 0 0 0.866 1.000 1.000 575 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 GNAQ(1), GNAS(2), GNB1(1), NFATC1(1), NFATC2(1), PPP3CB(1), PRKAR1A(1), PRKAR2A(1) 3010640 9 5 9 5 5 1 1 2 0 0 0.849 1.000 1.000 576 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(1), NFATC1(1), NFATC2(1), PPP3CB(1), SP1(1) 1783748 5 3 5 4 3 0 0 2 0 0 0.924 1.000 1.000 577 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST3A1(1), XYLT1(1), XYLT2(1) 564163 3 2 3 5 2 0 1 0 0 0 0.985 1.000 1.000 578 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST3A1(1), XYLT1(1), XYLT2(1) 564163 3 2 3 5 2 0 1 0 0 0 0.985 1.000 1.000 579 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(1), FASN(1), OLAH(1) 1392643 3 2 3 3 1 0 1 1 0 0 0.971 1.000 1.000 580 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 GLCE(1), HS3ST3A1(1), NDST4(1) 1777442 3 2 3 4 0 0 2 1 0 0 0.979 1.000 1.000 581 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 FASN(1), SCD(1) 1269295 2 2 2 2 1 0 0 1 0 0 0.943 1.000 1.000 582 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), HLA-DRA(1) 774370 2 2 2 2 0 2 0 0 0 0 0.840 1.000 1.000 583 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 PRKAR2A(1) 857860 1 1 1 3 1 0 0 0 0 0 0.993 1.000 1.000 584 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP17A1(1), HSD3B2(1) 799077 2 1 2 2 0 0 2 0 0 0 0.962 1.000 1.000 585 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 GNAQ(1) 1173582 1 1 1 3 1 0 0 0 0 0 0.996 1.000 1.000 586 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP17A1(1), HSD3B2(1) 799077 2 1 2 2 0 0 2 0 0 0 0.962 1.000 1.000 587 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 TNFRSF11A(1) 940151 1 1 1 2 0 0 1 0 0 0 0.988 1.000 1.000 588 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 SCAP(1) 1015024 1 1 1 2 1 0 0 0 0 0 0.974 1.000 1.000 589 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1) 624851 1 1 1 2 1 0 0 0 0 0 0.954 1.000 1.000 590 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 513463 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 591 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 661454 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 592 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 414020 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 593 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 348710 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 594 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 710699 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 595 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 559166 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 596 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 321328 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 597 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 1081967 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 598 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 750665 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 599 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 723338 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 600 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 394478 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 601 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 464228 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 602 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 388906 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 603 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 61457 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 604 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 157218 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 605 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 43206 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 606 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 1133101 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 607 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 186711 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 608 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 179065 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 609 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 410248 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 610 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 572322 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 611 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 449994 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 583016 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 788344 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 506397 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 1233346 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 616 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 488200 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000