Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.014 0.059 -9999.0 0.0 -0.156 11.0 11.0 epithelial cell differentiation 0.009 0.036 -9999.0 0.0 -0.086 10.0 10.0 CYFIP2 0.009 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.021 0.021 -9999.0 0.0 -0.119 1.0 1.0 EGFR 0.01 0.002 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.01 0.001 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.019 0.028 -9999.0 0.0 -0.158 1.0 1.0 CTNNB1 0.01 0.001 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.002 0.044 -9999.0 0.0 -0.103 12.0 12.0 AQP5 -0.046 0.1 -9999.0 0.0 -0.336 8.0 8.0 CTNND1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.018 0.024 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.028 -9999.0 0.0 -0.156 1.0 1.0 EGF 0.007 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.01 0.001 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.037 0.089 -9999.0 0.0 -0.336 6.0 6.0 cortical microtubule organization 0.009 0.036 -9999.0 0.0 -0.086 10.0 10.0 GO:0000145 -0.017 0.023 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.011 0.037 -9999.0 0.0 -0.086 10.0 10.0 MLLT4 0.01 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.023 0.026 -9999.0 0.0 -0.085 11.0 11.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.019 -9999.0 0.0 -0.093 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.013 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.018 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.026 0.018 -9999.0 0.0 -0.087 2.0 2.0 CDH1 0.009 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.003 0.04 -9999.0 0.0 -0.087 14.0 14.0 RhoA/GDP 0.009 0.035 -9999.0 0.0 -0.083 10.0 10.0 actin cytoskeleton organization -0.019 0.03 -9999.0 0.0 -0.096 10.0 10.0 IGF-1R heterotetramer 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.009 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DIAPH1 -0.058 0.193 -9999.0 0.0 -0.517 12.0 12.0 Wnt receptor signaling pathway -0.009 0.036 0.086 10.0 -9999.0 0.0 10.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.023 0.026 -9999.0 0.0 -0.086 11.0 11.0 CTNNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.031 -9999.0 0.0 -0.098 10.0 10.0 EFNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.019 0.024 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.006 0.035 -9999.0 0.0 -0.082 11.0 11.0 SEC6/SEC8 -0.023 0.027 -9999.0 0.0 -0.087 11.0 11.0 MGAT3 -0.016 0.028 -9999.0 0.0 -0.158 1.0 1.0 HGF/MET -0.004 0.045 -9999.0 0.0 -0.091 16.0 16.0 HGF 0.008 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.014 0.059 -9999.0 0.0 -0.156 11.0 11.0 actin cable formation -0.023 0.043 -9999.0 0.0 -0.173 2.0 2.0 KIAA1543 -0.015 0.026 -9999.0 0.0 -0.153 1.0 1.0 KIFC3 -0.018 0.025 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.01 0.001 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.018 0.025 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.014 0.015 -9999.0 0.0 -0.124 1.0 1.0 mol:GDP 0.009 0.036 -9999.0 0.0 -0.086 10.0 10.0 EXOC4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.018 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.018 0.025 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.01 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.023 0.024 -9999.0 0.0 -0.134 1.0 1.0 adherens junction assembly -0.036 0.059 -9999.0 0.0 -0.204 1.0 1.0 IGF-1R heterotetramer/IGF1 0.002 0.039 -9999.0 0.0 -0.088 12.0 12.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.012 0.022 -9999.0 0.0 -0.124 2.0 2.0 MET 0.01 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.018 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.023 0.018 -9999.0 0.0 -0.092 2.0 2.0 establishment of epithelial cell apical/basal polarity -0.023 0.026 -9999.0 0.0 -0.146 1.0 1.0 cortical actin cytoskeleton stabilization -0.014 0.059 -9999.0 0.0 -0.156 11.0 11.0 regulation of cell-cell adhesion -0.019 0.03 -9999.0 0.0 -0.096 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.014 0.059 -9999.0 0.0 -0.156 11.0 11.0