		Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
ZFPM1	24 (39%)	38	0.43268	1	0.098799	1	0.37489	1	0.87178	1	0.24003	1	0.74714	1	0.61031	1	0.92097	1	0.7424	1	0.53516	1
LACTB	19 (31%)	43	0.074059	1	0.37486	1	0.89306	1	0.56953	1	1	1	0.31489	1	0.93409	1	0.74991	1	0.64027	1	0.34046	1
CCDC102A	17 (27%)	45	0.66019	1	0.58963	1	1	1	0.50505	1	0.97642	1	0.82465	1	0.49845	1	0.46888	1	0.26082	1	0.43855	1
ZNF517	13 (21%)	49	0.94522	1	0.73365	1	NA	NA	NA	NA	0.82273	1	0.95244	1	0.27516	1	0.69418	1	0.86137	1	0.46074	1
MAL2	11 (18%)	51	0.91536	1	0.079519	1	0.28498	1	1	1	0.31397	1	0.51093	1	0.70705	1	0.26686	1	0.81159	1	0.50557	1
TOR3A	12 (19%)	50	0.19018	1	0.30736	1	0.1117	1	0.31265	1	0.55577	1	0.0050799	1	1	1	0.84243	1	0.62579	1	0.66614	1
TP53	13 (21%)	49	0.14059	1	0.34611	1	0.27524	1	0.60123	1	0.02993	1	0.32228	1	0.02428	1	0.59641	1	0.03323	1	0.083369	1
CLDN23	10 (16%)	52	0.22506	1	0.4032	1	1	1	0.34848	1	0.03533	1	0.2117	1	0.34491	1	0.18125	1	0.50672	1	0.30669	1
GDF1	5 (8%)	57	0.0265	1	0.13998	1	NA	NA	NA	NA	0.44155	1	0.35398	1	0.23826	1	0.51149	1	0.47328	1	0.60526	1
LZTR1	6 (10%)	56	0.02105	1	0.9426	1	NA	NA	NA	NA	0.13178	1	0.1175	1	0.18265	1	0.01468	1	0.38709	1	0.066059	1
ANKRD43	19 (31%)	43	0.377	1	0.17433	1	0.48078	1	0.59898	1	0.26756	1	0.22552	1	0.56533	1	0.10257	1	0.5206	1	0.59592	1
KCNK17	9 (15%)	53	0.15568	1	0.01034	1	0.37555	1	0.44037	1	0.074009	1	0.0095299	1	0.79715	1	0.54569	1	0.40523	1	0.56742	1
RINL	8 (13%)	54	0.32644	1	0.96235	1	0.074919	1	0.57853	1	0.47646	1	0.27508	1	0.26779	1	0.16861	1	0.098039	1	0.36163	1
ZAR1	11 (18%)	51	0.20926	1	0.29784	1	0.2292	1	0.79311	1	0.50704	1	0.86978	1	0.42809	1	0.97039	1	0.3001	1	0.70094	1
CTNNB1	8 (13%)	54	0.64145	1	0.32004	1	0.11162	1	0.3128	1	0.0085199	1	0.0060499	1	0.0052499	1	0.16741	1	0.04287	1	0.40349	1
APOE	7 (11%)	55	0.11114	1	0.70699	1	0.46716	1	0.38286	1	0.03756	1	0.39998	1	0.65151	1	0.79038	1	0.17058	1	0.92146	1
GPRIN2	8 (13%)	54	0.52638	1	0.17781	1	0.22688	1	0.69217	1	0.74485	1	0.39952	1	0.87997	1	0.75297	1	0.62655	1	0.50167	1
ASPDH	8 (13%)	54	0.28227	1	0.29925	1	0.71279	1	0.31377	1	0.0090299	1	0.3983	1	0.31368	1	0.03239	1	0.070229	1	0.01477	1
ERCC2	10 (16%)	52	0.21417	1	0.11681	1	0.095429	1	0.23282	1	0.50911	1	0.17185	1	0.38099	1	0.26848	1	0.37974	1	0.4886	1
IDUA	8 (13%)	54	0.0199	1	0.52632	1	0.81789	1	0.79131	1	0.57051	1	0.54561	1	0.68749	1	0.43228	1	0.81902	1	0.47617	1
C1ORF106	9 (15%)	53	0.40649	1	0.49655	1	0.26499	1	0.04808	1	0.41217	1	0.76231	1	0.6266	1	0.69139	1	0.59933	1	0.98759	1
C10ORF95	6 (10%)	56	0.23707	1	0.69127	1	NA	NA	NA	NA	0.60612	1	1	1	0.60988	1	0.35873	1	0.7718	1	0.78333	1
RGS9BP	8 (13%)	54	0.20208	1	0.57782	1	0.87913	1	0.12769	1	1	1	0.93466	1	0.23564	1	0.96255	1	0.5607	1	0.25443	1
THEM4	5 (8%)	57	0.12396	1	0.2141	1	NA	NA	NA	NA	0.44125	1	0.87569	1	0.53894	1	0.10672	1	0.51284	1	0.30367	1
TSC22D2	8 (13%)	54	0.65984	1	0.26518	1	0.67383	1	0.95508	1	0.68282	1	0.81663	1	0.87832	1	0.4297	1	0.62453	1	0.67125	1
SYT8	8 (13%)	54	0.17399	1	0.30519	1	0.46765	1	1	1	0.064429	1	0.17528	1	1	1	0.18389	1	0.63277	1	0.7048	1
PLIN5	5 (8%)	57	0.8963	1	0.75255	1	0.30934	1	0.38185	1	0.79725	1	0.66739	1	0.72096	1	0.26591	1	0.85659	1	0.31216	1
LRIG1	16 (26%)	46	0.44847	1	0.64883	1	0.28256	1	1	1	0.87069	1	0.61113	1	0.58648	1	0.43211	1	0.69415	1	0.98454	1
HHIPL1	6 (10%)	56	0.15129	1	0.57631	1	NA	NA	NA	NA	0.56636	1	0.51247	1	0.35981	1	0.42528	1	0.050789	1	0.29794	1
CCDC105	6 (10%)	56	0.83732	1	0.076319	1	0.46625	1	0.67328	1	0.93288	1	0.79269	1	0.86524	1	0.054569	1	0.33323	1	0.15325	1
C19ORF10	7 (11%)	55	0.76012	1	0.23094	1	0.81857	1	0.3917	1	0.28962	1	0.12539	1	0.65568	1	0.86499	1	0.34829	1	0.86211	1
OPRD1	12 (19%)	50	0.90671	1	0.58171	1	0.22857	1	0.48103	1	0.82645	1	0.96003	1	0.4938	1	0.6147	1	0.50475	1	0.52481	1
ATXN1	10 (16%)	52	0.44961	1	0.02952	1	0.1482	1	0.91588	1	0.13969	1	0.656	1	0.4288	1	0.87018	1	0.04684	1	0.59422	1
AATK	6 (10%)	56	0.098409	1	0.31565	1	NA	NA	NA	NA	0.22518	1	0.35492	1	1	1	0.54455	1	0.77077	1	0.7407	1
ZNF628	7 (11%)	55	0.77935	1	0.85044	1	1	1	0.67452	1	0.28081	1	0.11329	1	0.49889	1	0.50304	1	0.14981	1	0.66978	1
KRTAP4-5	5 (8%)	57	0.76965	1	0.82446	1	NA	NA	NA	NA	0.90539	1	0.87571	1	1	1	0.84242	1	1	1	0.96532	1
NOXA1	5 (8%)	57	0.15545	1	0.74119	1	NA	NA	NA	NA	0.23994	1	0.44233	1	0.10308	1	0.34967	1	0.19323	1	0.15442	1
TRIOBP	10 (16%)	52	0.90478	1	0.41865	1	0.46357	1	0.12881	1	1	1	0.11143	1	0.53287	1	0.86935	1	0.45679	1	0.89107	1
ZNF598	12 (19%)	50	0.64893	1	0.77274	1	0.58641	1	0.74832	1	0.82305	1	0.95242	1	0.90137	1	0.22711	1	0.1772	1	0.24966	1
IRX3	5 (8%)	57	0.31716	1	0.43606	1	NA	NA	NA	NA	0.53164	1	0.11763	1	0.54002	1	0.78074	1	0.16986	1	0.082949	1
WDR34	5 (8%)	57	0.19356	1	0.89768	1	NA	NA	NA	NA	0.85792	1	0.81619	1	0.60599	1	0.55101	1	0.22292	1	0.097189	1
BHLHE22	5 (8%)	57	0.9431	1	0.29444	1	0.8162	1	0.91631	1	0.04595	1	0.81196	1	1	1	0.83545	1	0.59281	1	0.81683	1
PANK2	5 (8%)	57	0.76789	1	0.79458	1	0.5858	1	0.3476	1	0.079289	1	0.050019	1	0.76721	1	0.35098	1	0.01758	1	0.30483	1
FPGS	5 (8%)	57	0.57276	1	0.090389	1	0.46807	1	0.34922	1	0.68555	1	0.59779	1	0.23833	1	0.62507	1	0.65872	1	0.88008	1
GLTPD2	6 (10%)	56	0.098899	1	0.82644	1	NA	NA	NA	NA	0.82982	1	0.39934	1	0.86636	1	0.53283	1	0.33384	1	0.22792	1
TNIP2	5 (8%)	57	0.84479	1	0.4246	1	NA	NA	NA	NA	0.74594	1	0.87538	1	0.82283	1	0.41346	1	0.60766	1	0.26506	1
AKAP2	6 (10%)	56	0.070939	1	0.82449	1	0.91701	1	0.75521	1	0.82938	1	0.59267	1	0.65632	1	0.28149	1	0.93953	1	0.70741	1
RREB1	5 (8%)	57	0.2778	1	0.85962	1	NA	NA	NA	NA	0.61892	1	1	1	0.23595	1	0.54576	1	0.28557	1	0.48949	1
TPO	12 (19%)	50	0.2828	1	0.52663	1	0.88593	1	0.69298	1	0.22082	1	0.12495	1	0.2213	1	0.3423	1	0.47663	1	0.19547	1
OBSCN	18 (29%)	44	0.96346	1	0.33994	1	0.89135	1	0.54522	1	0.56802	1	0.80753	1	0.21911	1	0.49674	1	0.95591	1	0.56283	1
SNED1	5 (8%)	57	0.31571	1	0.89892	1	NA	NA	NA	NA	0.43905	1	0.66762	1	0.03268	1	0.66167	1	0.29753	1	0.88045	1
MEN1	5 (8%)	57	0.2854	1	0.01784	1	NA	NA	NA	NA	0.0189	1	0.0065899	1	0.17358	1	0.04278	1	0.02407	1	0.075459	1
BTBD11	6 (10%)	56	1	1	0.88448	1	NA	NA	NA	NA	0.79806	1	1	1	0.17439	1	0.18369	1	0.34278	1	0.2367	1
RNF149	4 (6%)	58	0.21491	1	0.060759	1	0.67473	1	0.95362	1	0.43902	1	0.60067	1	0.82162	1	0.25994	1	0.60571	1	0.55265	1
KIAA1984	4 (6%)	58	0.1488	1	0.11692	1	1	1	0.50595	1	0.10255	1	0.04961	1	0.18033	1	0.58401	1	0.38871	1	0.96657	1
CCDC150	4 (6%)	58	0.53695	1	0.58069	1	1	1	0.60186	1	0.17761	1	0.11703	1	0.53502	1	0.20987	1	0.16944	1	0.29927	1
FAM18B2	4 (6%)	58	0.22984	1	0.96559	1	NA	NA	NA	NA	0.22272	1	0.48117	1	0.097289	1	0.50971	1	0.02857	1	0.60301	1
MUC5B	22 (35%)	40	0.9973	1	0.13312	1	0.53838	1	0.81241	1	0.77008	1	0.67007	1	0.93605	1	0.61673	1	0.87443	1	0.96726	1
PTPLA	4 (6%)	58	0.23062	1	0.44439	1	NA	NA	NA	NA	0.61728	1	0.4407	1	1	1	1	1	0.19287	1	0.49665	1
SRPX	3 (5%)	59	0.66139	1	0.44383	1	NA	NA	NA	NA	0.61747	1	1	1	1	1	0.71785	1	1	1	0.84861	1
GARS	19 (31%)	43	0.4308	1	0.22848	1	0.51743	1	0.33511	1	0.30784	1	0.10161	1	0.074439	1	0.40265	1	0.17418	1	0.4843	1
PRSS27	3 (5%)	59	0.086469	1	0.73999	1	NA	NA	NA	NA	0.12742	1	0.050239	1	0.49947	1	1	1	0.69035	1	0.49291	1
SEMA5B	8 (13%)	54	0.12837	1	0.53357	1	0.58763	1	0.17476	1	0.46145	1	0.21353	1	0.48605	1	0.29818	1	0.44387	1	0.60256	1
CD320	4 (6%)	58	0.96828	1	1	1	NA	NA	NA	NA	1	1	0.65386	1	0.36674	1	0.22457	1	0.11076	1	0.2274	1
TAF5	4 (6%)	58	0.96703	1	1	1	0.31004	1	0.95426	1	1	1	0.87571	1	0.099489	1	0.1155	1	0.4693	1	0.16676	1
NEFH	6 (10%)	56	0.64002	1	0.36577	1	NA	NA	NA	NA	0.079239	1	0.051049	1	0.53519	1	0.21125	1	0.00318	1	0.18244	1
DMKN	3 (5%)	59	0.099739	1	0.44084	1	NA	NA	NA	NA	0.6173	1	0.44314	1	0.051199	1	0.57074	1	0.12037	1	0.89258	1
NPTX1	3 (5%)	59	0.25596	1	0.5504	1	NA	NA	NA	NA	1	1	0.81224	1	0.27695	1	0.79567	1	0.48499	1	0.76172	1
NOTCH2	5 (8%)	57	0.03152	1	0.82256	1	NA	NA	NA	NA	0.52842	1	0.11881	1	0.01402	1	0.31869	1	0.02872	1	0.55445	1
RNF39	5 (8%)	57	0.78775	1	0.41056	1	0.074429	1	0.79361	1	0.14646	1	0.26343	1	0.3593	1	0.70299	1	0.38476	1	0.50856	1
KBTBD13	9 (15%)	53	0.76755	1	0.40281	1	0.48851	1	0.79294	1	0.70859	1	0.1176	1	0.53425	1	0.33098	1	0.66103	1	0.90487	1
IER5	3 (5%)	59	0.2593	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
SCRT1	3 (5%)	59	0.94197	1	0.59292	1	NA	NA	NA	NA	0.46801	1	0.61762	1	0.76821	1	0.795	1	0.36923	1	1	1
KNDC1	9 (15%)	53	0.66854	1	0.01582	1	0.58593	1	0.55496	1	0.04098	1	0.32666	1	0.51629	1	0.3652	1	0.36183	1	0.5492	1
MAP1S	5 (8%)	57	0.51587	1	0.36393	1	0.28516	1	0.41691	1	0.44444	1	1	1	1	1	0.83577	1	1	1	0.81644	1
RGMB	6 (10%)	56	0.3669	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
LRP11	6 (10%)	56	0.32062	1	0.38834	1	NA	NA	NA	NA	0.79819	1	0.66572	1	1	1	0.93553	1	0.92382	1	0.59469	1
AR	4 (6%)	58	0.30755	1	0.28219	1	1	1	0.9544	1	0.46698	1	0.44407	1	0.77086	1	1	1	0.19205	1	1	1
VARS	6 (10%)	56	0.54405	1	0.35901	1	0.31062	1	0.38075	1	0.48307	1	0.067699	1	1	1	0.86115	1	0.83627	1	1	1
SEZ6L2	8 (13%)	54	0.65582	1	0.143	1	0.87982	1	0.78795	1	0.83074	1	1	1	0.86598	1	0.62782	1	1	1	0.57593	1
PABPC1	4 (6%)	58	0.33073	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
FANK1	3 (5%)	59	1	1	0.051779	1	NA	NA	NA	NA	0.86554	1	0.28794	1	0.27912	1	0.23248	1	0.27976	1	0.03672	1
NMU	5 (8%)	57	0.33211	1	0.8407	1	NA	NA	NA	NA	0.12528	1	0.61697	1	0.82267	1	0.54478	1	1	1	0.15965	1
ADAD2	4 (6%)	58	0.19145	1	0.48016	1	NA	NA	NA	NA	0.74605	1	0.17323	1	0.097869	1	0.51003	1	0.4686	1	0.87877	1
CLIC6	5 (8%)	57	0.22784	1	0.43418	1	NA	NA	NA	NA	0.68484	1	0.1179	1	0.18483	1	0.58374	1	0.04871	1	0.96719	1
PCDHB13	5 (8%)	57	0.52923	1	0.02808	1	NA	NA	NA	NA	0.44072	1	0.35574	1	0.37005	1	0.059589	1	0.12942	1	0.095719	1
PLEC	13 (21%)	49	0.68779	1	0.2018	1	0.11119	1	0.04722	1	0.1413	1	0.71966	1	0.6247	1	0.6316	1	0.3498	1	0.062589	1
AMDHD1	10 (16%)	52	0.28428	1	0.66972	1	1	1	0.34984	1	0.59082	1	0.13634	1	0.72992	1	0.85328	1	0.54064	1	0.87991	1
DSPP	9 (15%)	53	0.11997	1	0.15875	1	0.23042	1	0.69196	1	1	1	0.48348	1	0.72899	1	0.53954	1	0.42743	1	0.35501	1
TMEM189	3 (5%)	59	0.7828	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
CRIPAK	10 (16%)	52	0.12966	1	0.52986	1	0.8192	1	0.9336	1	0.4229	1	0.68975	1	0.35043	1	0.32777	1	0.49313	1	0.44621	1
PDCD6	3 (5%)	59	0.60636	1	0.64258	1	NA	NA	NA	NA	NA	NA	NA	NA	1	1	0.63941	1	1	1	0.68577	1
MAP7	3 (5%)	59	0.85743	1	0.82603	1	NA	NA	NA	NA	1	1	0.81289	1	0.49805	1	0.79318	1	0.48125	1	0.76531	1
NOM1	6 (10%)	56	0.63894	1	0.88538	1	NA	NA	NA	NA	0.64658	1	1	1	1	1	0.78751	1	1	1	0.15969	1
SHOX2	3 (5%)	59	0.04347	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
HSD17B1	4 (6%)	58	0.45633	1	0.47901	1	0.87833	1	0.50662	1	0.90519	1	0.0078199	1	0.82431	1	0.84042	1	1	1	0.31234	1
PRKAR1A	6 (10%)	56	0.83815	1	0.47058	1	0.82007	1	0.79215	1	0.22806	1	0.39818	1	0.16896	1	0.58747	1	0.088339	1	0.18003	1
KRTAP5-5	3 (5%)	59	0.063629	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
DLEU7	3 (5%)	59	0.71492	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
FEZ2	3 (5%)	59	0.8551	1	0.04022	1	NA	NA	NA	NA	0.23974	1	0.81452	1	0.2795	1	0.79056	1	0.48461	1	0.49687	1
RASIP1	6 (10%)	56	0.063419	1	0.18101	1	NA	NA	NA	NA	0.0028	1	0.18947	1	0.11655	1	0.69847	1	0.04345	1	0.73884	1
JMJD4	3 (5%)	59	0.49789	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
COQ2	5 (8%)	57	0.13276	1	0.085019	1	NA	NA	NA	NA	0.44169	1	0.60261	1	1	1	0.66913	1	0.7699	1	0.4913	1
UQCRFS1	5 (8%)	57	0.62253	1	0.45202	1	NA	NA	NA	NA	1	1	0.87677	1	0.6091	1	0.20258	1	0.59324	1	0.11798	1
C9ORF66	5 (8%)	57	0.40709	1	1	1	NA	NA	NA	NA	0.36787	1	0.51389	1	1	1	0.9358	1	0.92295	1	0.88216	1
POLRMT	4 (6%)	58	0.51722	1	0.083969	1	0.10799	1	0.34944	1	0.36893	1	0.058129	1	0.18294	1	0.26205	1	0.23364	1	0.55047	1
ADAMTS7	4 (6%)	58	0.01008	1	0.72162	1	0.0276	1	0.35125	1	0.13149	1	0.4384	1	0.1007	1	0.26314	1	0.20918	1	0.34923	1
BTNL9	4 (6%)	58	0.056559	1	0.18004	1	NA	NA	NA	NA	0.15295	1	0.096549	1	0.49431	1	1	1	0.69019	1	1	1
NF1	7 (11%)	55	0.33585	1	0.82788	1	0.81869	1	0.39164	1	0.31389	1	0.19016	1	0.87685	1	0.88348	1	0.04946	1	0.4175	1
ZNF814	3 (5%)	59	0.94304	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
RNF135	3 (5%)	59	0.7166	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
CSGALNACT2	3 (5%)	59	0.85591	1	0.22085	1	NA	NA	NA	NA	0.772	1	0.81565	1	0.27944	1	0.87393	1	0.48163	1	0.94155	1
SPIRE2	3 (5%)	59	0.94217	1	0.13079	1	NA	NA	NA	NA	1	1	0.81189	1	0.76764	1	0.79348	1	0.54428	1	1	1
CYP4A22	4 (6%)	58	0.15217	1	0.82369	1	NA	NA	NA	NA	0.22392	1	0.48466	1	0.18187	1	0.19891	1	0.04815	1	0.87929	1
HLA-A	3 (5%)	59	0.71753	1	0.94985	1	NA	NA	NA	NA	0.8657	1	0.19595	1	0.76758	1	0.51004	1	1	1	0.34732	1
GLI3	5 (8%)	57	0.12586	1	0.6231	1	NA	NA	NA	NA	0.90668	1	0.87596	1	0.36995	1	0.4139	1	0.51194	1	0.13767	1
