		Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	196 (50%)	199	9.9999e-06	0.000736	0.00083999	0.0283	3e-04	0.0128	0.02421	0.316	5e-05	0.0027	2e-05	0.00125	0.00155	0.0448	0.14416	0.618	0.0056199	0.126	0.00141	0.0439
RB1	70 (18%)	325	9.9999e-06	0.000736	0.04065	0.397	5e-05	0.0027	0.00021	0.00945	8.9999e-05	0.00456	2e-05	0.00125	0.00011	0.00524	0.3676	0.781	0.00067999	0.025	0.00154	0.0448
ELF3	46 (12%)	349	0.84886	0.975	0.10853	0.541	0.62745	0.911	0.063809	0.46	0.076669	0.474	0.0403	0.397	0.41599	0.806	0.63906	0.911	0.25941	0.713	0.5846	0.88
TSC1	33 (8%)	362	0.21597	0.669	0.93136	0.992	0.31276	0.732	0.20451	0.669	0.32028	0.745	0.23427	0.678	0.52656	0.854	0.072519	0.47	0.59085	0.883	0.85984	0.978
PIK3CA	86 (22%)	309	0.80103	0.966	0.94853	0.992	0.84226	0.974	0.94671	0.992	0.02397	0.316	0.76495	0.95	0.74316	0.945	0.68531	0.924	0.96967	1	0.83897	0.974
RHOB	26 (7%)	369	0.37122	0.781	0.29416	0.727	0.91839	0.987	0.6771	0.919	0.2479	0.702	0.15905	0.638	0.42022	0.807	0.82922	0.97	0.77146	0.953	0.80643	0.966
KDM6A	103 (26%)	292	0.38706	0.795	0.00222	0.0607	0.051719	0.414	0.22193	0.669	0.00446	0.106	0.01129	0.183	0.11704	0.558	0.16925	0.638	0.03729	0.382	0.17013	0.638
CDKN2A	26 (7%)	369	0.85596	0.977	0.03863	0.391	0.68094	0.919	0.02751	0.343	0.28396	0.726	0.4474	0.823	0.0066699	0.14	0.19037	0.664	0.078999	0.478	0.00076999	0.0271
ARID1A	97 (25%)	298	0.24487	0.701	0.48797	0.85	0.76632	0.95	0.52281	0.854	0.14843	0.626	0.78202	0.956	0.0493	0.399	0.066119	0.46	0.11019	0.541	0.6595	0.914
STAG2	56 (14%)	339	0.052989	0.414	0.03001	0.348	0.10609	0.541	0.18971	0.664	0.50806	0.85	0.0067299	0.14	0.10155	0.541	0.22213	0.669	0.04525	0.399	0.03024	0.348
ZFP36L1	25 (6%)	370	0.96098	0.998	0.38447	0.795	0.30724	0.727	0.93157	0.992	0.50945	0.851	0.23453	0.678	0.72299	0.933	0.32664	0.754	0.5674	0.88	0.24643	0.702
CDKN1A	35 (9%)	360	0.95047	0.992	0.16993	0.638	0.30518	0.727	0.03288	0.35	0.72018	0.932	0.35564	0.781	0.17213	0.638	0.087389	0.499	0.29614	0.727	0.50425	0.85
EP300	61 (15%)	334	0.12965	0.587	0.81347	0.966	0.42093	0.807	0.66334	0.914	0.27255	0.717	0.30955	0.727	0.57934	0.88	0.84242	0.974	0.46829	0.843	0.86603	0.98
MLL2	114 (29%)	281	0.15561	0.638	0.60766	0.897	0.90776	0.986	0.10336	0.541	0.67974	0.919	0.93652	0.992	0.44812	0.823	0.34565	0.776	0.5045	0.85	0.068039	0.46
FGFR3	56 (14%)	339	9.9999e-06	0.000736	9.9999e-06	0.000736	9.9999e-06	0.000736	9.9999e-06	0.000736	9.9999e-06	0.000736	9.9999e-06	0.000736	9.9999e-06	0.000736	0.00041	0.0166	9.9999e-06	0.000736	9.9999e-06	0.000736
ERCC2	38 (10%)	357	0.54839	0.871	0.42372	0.807	0.04622	0.399	0.2536	0.711	0.39972	0.795	0.70531	0.928	0.16865	0.638	0.42829	0.807	0.14715	0.624	0.39556	0.795
CREBBP	48 (12%)	347	0.47214	0.848	0.49364	0.85	0.64427	0.914	0.8186	0.967	0.26369	0.714	0.54331	0.866	0.087029	0.499	0.00348	0.0854	0.13925	0.6	0.054209	0.414
HRAS	17 (4%)	378	0.24442	0.701	0.1993	0.669	0.50605	0.85	0.84556	0.975	0.84302	0.974	0.77723	0.956	0.34055	0.773	0.42925	0.807	0.35836	0.781	0.27102	0.717
FOXA1	14 (4%)	381	0.74547	0.945	0.5202	0.854	0.81445	0.966	0.16576	0.638	0.36632	0.781	0.22813	0.672	0.27344	0.717	0.15799	0.638	0.02097	0.288	0.27129	0.717
KRAS	13 (3%)	382	0.071779	0.469	0.62179	0.909	0.58351	0.88	0.15226	0.638	0.10791	0.541	0.17285	0.638	0.63859	0.911	0.56198	0.879	0.7032	0.928	0.58642	0.88
RHOA	18 (5%)	377	0.49576	0.85	0.3529	0.781	0.40308	0.796	0.1782	0.647	0.88552	0.98	0.48047	0.85	0.18071	0.648	0.11087	0.541	0.67611	0.919	0.8158	0.966
KIAA1267	24 (6%)	371	0.4062	0.797	0.04913	0.399	0.95488	0.994	0.64728	0.914	0.33888	0.771	0.21166	0.669	0.25117	0.706	0.78082	0.956	0.056299	0.426	0.52685	0.854
MLL	44 (11%)	351	0.04275	0.399	0.70785	0.928	0.064429	0.46	0.17073	0.638	0.40069	0.795	0.073109	0.47	0.0064599	0.14	0.0109	0.18	0.03221	0.35	0.00471	0.109
FAT1	50 (13%)	345	0.80684	0.966	0.067439	0.46	0.23021	0.676	0.12415	0.575	0.39243	0.795	0.19375	0.665	0.11274	0.547	0.03241	0.35	0.34878	0.78	0.081539	0.486
KLF5	23 (6%)	372	0.66067	0.914	0.95197	0.992	0.04922	0.399	0.6569	0.914	0.58211	0.88	0.70817	0.928	0.24826	0.702	0.062389	0.455	0.15681	0.638	0.084549	0.496
PTEN	14 (4%)	381	0.83372	0.97	0.13507	0.6	0.47782	0.85	0.37144	0.781	0.13833	0.6	0.16203	0.638	0.43393	0.812	1	1	0.93783	0.992	0.66654	0.915
C3ORF70	17 (4%)	378	0.57047	0.88	0.24857	0.702	1	1	0.66758	0.915	0.87165	0.98	0.56887	0.88	0.8754	0.98	0.49372	0.85	0.95139	0.992	0.91444	0.987
PSIP1	20 (5%)	375	0.75039	0.945	0.04815	0.399	0.0178	0.257	0.16727	0.638	0.75198	0.945	0.01628	0.249	0.10683	0.541	0.94219	0.992	0.02803	0.344	0.02571	0.331
MLL3	74 (19%)	321	0.0094899	0.167	0.62805	0.911	0.1158	0.555	0.22462	0.669	0.40152	0.795	0.47931	0.85	0.36916	0.781	0.02885	0.345	0.12428	0.575	0.29701	0.727
ASXL2	36 (9%)	359	0.82034	0.967	0.78473	0.956	0.092479	0.511	0.21696	0.669	0.52174	0.854	0.593	0.883	0.32841	0.756	0.21319	0.669	0.42819	0.807	0.49037	0.85
ZBTB7B	11 (3%)	384	0.90567	0.986	0.87983	0.98	0.78738	0.956	0.53437	0.859	0.42002	0.807	0.39683	0.795	0.52562	0.854	0.21413	0.669	0.67176	0.919	0.40679	0.797
RXRA	24 (6%)	371	0.13465	0.6	0.01036	0.177	0.58255	0.88	0.27695	0.721	0.30975	0.727	0.25757	0.713	0.28655	0.727	0.34545	0.776	0.5407	0.865	0.37075	0.781
FBXW7	30 (8%)	365	0.02189	0.296	0.067029	0.46	0.71056	0.929	0.44073	0.819	0.49044	0.85	0.17081	0.638	0.36506	0.781	0.19819	0.669	0.20914	0.669	0.04687	0.399
RBM10	22 (6%)	373	0.28806	0.727	0.45439	0.828	0.48423	0.85	0.90536	0.986	0.30436	0.727	0.88581	0.98	0.20854	0.669	0.20964	0.669	0.30869	0.727	0.27996	0.724
NFE2L2	24 (6%)	371	0.059369	0.437	0.01449	0.226	0.12006	0.562	0.068719	0.46	0.0084399	0.157	0.0082999	0.157	0.089039	0.5	0.65622	0.914	0.55079	0.873	0.04462	0.399
CUL1	19 (5%)	376	0.81189	0.966	0.6006	0.891	0.10665	0.541	0.2979	0.727	0.78954	0.957	0.45768	0.829	0.8542	0.977	0.83132	0.97	0.80599	0.966	0.3006	0.727
HLA-A	5 (1%)	390	0.48968	0.85	1	1	NA	NA	NA	NA	0.29662	0.727	1	1	0.90692	0.986	0.29099	0.727	0.93006	0.992	0.69325	0.926
GNA13	12 (3%)	383	0.79788	0.963	0.22018	0.669	0.36615	0.781	0.77539	0.956	0.69407	0.926	0.36539	0.781	0.5417	0.865	0.21666	0.669	0.067379	0.46	0.53471	0.859
NUDT11	7 (2%)	388	0.81078	0.966	0.40565	0.797	0.00323	0.0835	0.81239	0.966	0.24369	0.701	0.7164	0.931	0.75845	0.95	0.37042	0.781	0.34441	0.776	0.57845	0.88
MBD1	12 (3%)	383	0.19275	0.664	0.87463	0.98	0.50793	0.85	0.29444	0.727	0.20707	0.669	0.66113	0.914	0.79621	0.963	0.59718	0.888	0.57451	0.88	0.76913	0.951
SCARF2	8 (2%)	387	0.38472	0.795	0.053399	0.414	0.32477	0.754	0.19882	0.669	0.070179	0.462	0.16265	0.638	0.87111	0.98	0.49632	0.85	0.27934	0.724	0.55544	0.874
FOXQ1	14 (4%)	381	0.73691	0.943	0.76673	0.95	0.61843	0.906	0.26793	0.717	0.73296	0.941	0.88671	0.98	0.83096	0.97	0.84131	0.974	1	1	0.96846	1
FAM47C	21 (5%)	374	0.39655	0.795	0.82111	0.967	0.0069799	0.141	0.74313	0.945	0.3887	0.795	0.71817	0.932	0.30517	0.727	0.15466	0.638	0.67702	0.919	0.40753	0.797
METTL3	17 (4%)	378	0.76115	0.95	0.72241	0.933	1	1	0.69134	0.926	0.55815	0.876	0.2184	0.669	0.41232	0.802	0.29926	0.727	0.57479	0.88	0.11002	0.541
ZNF185	5 (1%)	390	0.86851	0.98	0.70762	0.928	0.076269	0.474	0.35634	0.781	0.37835	0.792	0.86384	0.98	0.65675	0.914	0.65167	0.914	0.74458	0.945	0.25756	0.713
ERBB2	48 (12%)	347	0.76208	0.95	0.22297	0.669	0.52955	0.854	0.67878	0.919	0.4493	0.823	0.20688	0.669	0.070059	0.462	0.23288	0.678	0.36151	0.781	0.39306	0.795
ATM	53 (13%)	342	0.48172	0.85	0.17948	0.647	0.17193	0.638	0.01827	0.26	0.63061	0.911	0.65382	0.914	0.26886	0.717	0.20669	0.669	0.27627	0.721	0.097609	0.534
UNC93B1	7 (2%)	388	0.56385	0.88	0.65659	0.914	0.51142	0.852	0.89589	0.982	0.93029	0.992	0.88848	0.98	1	1	1	1	0.67254	0.919	0.66343	0.914
SF1	10 (3%)	385	0.36457	0.781	0.63827	0.911	0.30615	0.727	0.01722	0.254	0.89507	0.982	1	1	0.0033	0.0835	0.01675	0.251	0.092739	0.511	0.49035	0.85
BCL2L1	4 (1%)	391	0.066219	0.46	0.03264	0.35	0.076939	0.474	0.52494	0.854	0.7123	0.929	0.69185	0.926	0.74885	0.945	1	1	0.39603	0.795	0.81573	0.966
DNAH6	16 (4%)	379	0.73384	0.941	0.13907	0.6	0.45195	0.826	0.19104	0.664	0.02053	0.287	0.01235	0.196	0.33035	0.758	0.13663	0.6	0.068539	0.46	0.086129	0.499
HES1	11 (3%)	384	1	1	0.948	0.992	0.58181	0.88	0.1273	0.583	0.91954	0.987	0.63193	0.911	0.35391	0.781	0.30812	0.727	0.87764	0.98	0.49842	0.85
ERBB3	41 (10%)	354	0.47883	0.85	0.35869	0.781	0.9007	0.985	0.26776	0.717	0.52155	0.854	0.21892	0.669	0.8575	0.977	0.85596	0.977	0.94408	0.992	0.30063	0.727
TXNIP	17 (4%)	378	0.72459	0.933	0.49366	0.85	0.12805	0.583	0.74588	0.945	0.30962	0.727	0.0086199	0.157	0.71943	0.932	0.42924	0.807	0.92728	0.992	0.77908	0.956
THRAP3	14 (4%)	381	0.84713	0.975	0.64573	0.914	1	1	1	1	1	1	0.78424	0.956	0.33567	0.766	0.92038	0.987	0.96024	0.998	0.84655	0.975
SPTAN1	45 (11%)	350	0.6518	0.914	0.1575	0.638	0.26156	0.713	0.11983	0.562	0.26737	0.717	0.20289	0.669	0.22423	0.669	0.58583	0.88	0.30863	0.727	0.17234	0.638
ARID1B	23 (6%)	372	0.52878	0.854	0.089469	0.5	0.18657	0.664	0.5852	0.88	0.099179	0.539	0.057859	0.431	0.21031	0.669	0.16255	0.638	0.17541	0.64	0.10883	0.541
NRAS	7 (2%)	388	0.29535	0.727	0.43969	0.819	1	1	0.63788	0.911	0.65844	0.914	0.63831	0.911	0.42298	0.807	0.36754	0.781	0.04343	0.399	0.22475	0.669
RPTN	15 (4%)	380	0.93779	0.992	0.3505	0.781	0.87208	0.98	0.76418	0.95	0.49414	0.85	1	1	0.21441	0.669	0.22008	0.669	0.78641	0.956	0.78217	0.956
RAI1	21 (5%)	374	0.65376	0.914	0.13746	0.6	0.11896	0.562	0.077189	0.474	0.02698	0.341	0.03243	0.35	0.17358	0.638	0.43027	0.807	0.39601	0.795	0.56479	0.88
TMCO4	12 (3%)	383	0.75338	0.945	0.053179	0.414	0.55419	0.874	0.2871	0.727	0.04795	0.399	0.075349	0.474	0.21524	0.669	1	1	0.04922	0.399	0.20347	0.669
CNOT1	21 (5%)	374	0.44169	0.819	0.16202	0.638	0.36274	0.781	0.3888	0.795	0.60548	0.895	0.45502	0.828	0.55482	0.874	0.89504	0.982	0.91046	0.986	0.88131	0.98
PARD3	22 (6%)	373	0.1084	0.541	0.64674	0.914	0.41897	0.807	0.36666	0.781	0.088469	0.5	0.85191	0.977	0.97092	1	0.26075	0.713	0.87603	0.98	0.26132	0.713
EZR	12 (3%)	383	0.44582	0.823	0.48561	0.85	1	1	0.38432	0.795	0.41279	0.802	0.87125	0.98	0.93629	0.992	0.17986	0.647	0.89201	0.982	0.73138	0.94
MOAP1	7 (2%)	388	0.80709	0.966	0.30064	0.727	0.52272	0.854	0.60167	0.891	0.22712	0.672	0.63721	0.911	0.27217	0.717	0.85672	0.977	0.90839	0.986	0.75306	0.945
SF3B1	24 (6%)	371	0.34283	0.776	0.88516	0.98	0.50586	0.85	0.45722	0.829	0.70149	0.928	0.61625	0.904	0.94748	0.992	0.59238	0.883	0.38516	0.795	0.14695	0.624
RUNX1	13 (3%)	382	0.65202	0.914	0.67531	0.919	0.26072	0.713	0.51784	0.854	0.00225	0.0607	0.04647	0.399	0.19221	0.664	0.91672	0.987	0.81333	0.966	0.00109	0.0353
MEGF8	20 (5%)	375	0.6643	0.914	0.44071	0.819	0.68921	0.926	1	1	0.13749	0.6	0.54015	0.865	0.2154	0.669	0.58742	0.88	0.90937	0.986	0.88899	0.98
CASP8	14 (4%)	381	0.49739	0.85	0.48804	0.85	0.082209	0.486	0.10104	0.541	0.87893	0.98	0.57717	0.88	0.16258	0.638	0.40151	0.795	0.54696	0.87	0.28323	0.726
DAZAP1	6 (2%)	389	0.36475	0.781	0.087529	0.499	0.55552	0.874	0.31994	0.745	0.4598	0.831	0.01047	0.177	0.19177	0.664	0.37762	0.792	0.47483	0.85	0.58619	0.88
USP28	13 (3%)	382	0.39652	0.795	0.93878	0.992	0.58345	0.88	0.39722	0.795	0.83318	0.97	1	1	0.75178	0.945	1	1	0.61312	0.901	0.40961	0.799
SETD2	27 (7%)	368	0.70513	0.928	0.71163	0.929	0.50189	0.85	0.82587	0.97	1	1	0.81917	0.967	0.26266	0.714	0.42965	0.807	0.83213	0.97	0.86472	0.98
EME1	5 (1%)	390	0.62845	0.911	0.28694	0.727	0.69665	0.928	0.28211	0.726	0.52293	0.854	0.3351	0.766	0.49324	0.85	0.10458	0.541	0.16012	0.638	0.10874	0.541
ADC	5 (1%)	390	0.081699	0.486	0.9339	0.992	0.69408	0.926	0.70042	0.928	0.9171	0.987	1	1	1	1	0.5262	0.854	0.56911	0.88	0.76159	0.95
CNOT3	10 (3%)	385	0.11018	0.541	0.32673	0.754	0.70202	0.928	0.17411	0.638	0.04831	0.399	0.11553	0.555	0.0087099	0.157	0.44643	0.823	0.0073499	0.145	0.00059999	0.0231
SSH3	15 (4%)	380	0.20742	0.669	0.057969	0.431	0.03417	0.359	0.04379	0.399	0.077889	0.474	0.39455	0.795	0.12543	0.577	0.21983	0.669	0.03693	0.382	0.029	0.345
AHR	22 (6%)	373	0.63147	0.911	0.10268	0.541	0.15703	0.638	0.77785	0.956	0.52137	0.854	0.074089	0.473	0.70469	0.928	0.94798	0.992	0.50412	0.85	0.20593	0.669
EIF4A2	11 (3%)	384	0.51806	0.854	0.71375	0.929	0.3994	0.795	0.61094	0.9	0.73847	0.943	0.26076	0.713	0.42692	0.807	0.1877	0.664	0.62252	0.909	0.054079	0.414
EPHA2	19 (5%)	376	0.94244	0.992	0.0398	0.397	0.64105	0.913	0.49379	0.85	0.90125	0.985	1	1	0.75189	0.945	0.50784	0.85	0.91421	0.987	0.29511	0.727
OGDH	19 (5%)	376	0.21946	0.669	0.13043	0.587	0.88171	0.98	0.56035	0.878	0.82324	0.968	0.86653	0.98	0.46698	0.842	0.23128	0.676	0.43016	0.807	0.27342	0.717
POU3F1	3 (1%)	392	0.57739	0.88	0.18927	0.664	0.03054	0.348	0.63288	0.911	0.04464	0.399	0.79152	0.958	0.28248	0.726	0.16818	0.638	0.04419	0.399	0.22817	0.672
