rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNGT1(1), PLCB1(5), TUB(2)	517190	8	7	8	0	2	0	1	2	3	0	0.170	0.00527	1.000
2	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), NFKBIA(3), PLCB1(5)	608492	9	8	9	2	1	0	1	3	4	0	0.531	0.00550	1.000
3	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(6), EP300(3), NCOA1(1), NCOA2(1), PPARG(1)	1337157	12	11	12	1	1	1	3	5	2	0	0.139	0.00721	1.000
4	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(1), ITPKA(1), PDE1B(1), PLCB1(5)	818032	8	8	8	1	0	2	1	2	3	0	0.326	0.00885	1.000
5	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(6), DFFA(1), HMGB2(1), PRF1(2)	788678	10	10	10	2	3	0	2	3	2	0	0.357	0.0131	1.000
6	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	51556	2	2	2	0	1	0	0	1	0	0	0.590	0.0155	1.000
7	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(1)	84242	2	2	2	0	0	1	0	0	1	0	0.411	0.0217	1.000
8	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3D(1), CD3G(1), CD58(1), IL6(2), KITLG(1)	460709	6	5	6	1	1	1	1	1	2	0	0.372	0.0251	1.000
9	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(2)	222942	3	3	2	0	2	0	0	0	1	0	0.305	0.0494	1.000
10	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(2), AASS(2)	342070	4	4	4	0	0	1	1	1	1	0	0.384	0.0502	1.000
11	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGEF1(1), GNA13(2), GNGT1(1), MYLK(3), PLCB1(5)	1504290	12	11	12	1	3	1	1	2	5	0	0.118	0.0624	1.000
12	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(1)	488712	4	4	4	1	1	0	1	0	2	0	0.543	0.0662	1.000
13	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(1)	144812	2	2	2	0	1	1	0	0	0	0	0.477	0.0748	1.000
14	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDKN1A(2), CDKN2A(1), E2F1(2), E2F2(1), PRB1(1)	545497	7	6	7	2	2	2	1	0	2	0	0.500	0.0777	1.000
15	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(1), AGT(1), AGTR1(2), AGTR2(3)	741110	7	7	7	1	1	0	0	6	0	0	0.422	0.0797	1.000
16	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), CD3G(1), IL2RA(1), TGFB2(1), TGFBR3(2)	785579	6	6	6	0	1	2	0	1	2	0	0.0787	0.0905	1.000
17	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDKN1A(2), NEK1(3)	565779	5	5	5	0	3	1	0	1	0	0	0.229	0.0939	1.000
18	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GGT1(1), SHMT1(1), SHMT2(1)	423071	5	5	5	1	1	1	1	1	1	0	0.428	0.0993	1.000
19	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(2), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1)	476131	6	5	6	0	1	1	2	2	0	0	0.138	0.111	1.000
20	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(3), PHPT1(1), THTPA(2)	464267	6	5	6	2	1	1	1	2	1	0	0.612	0.115	1.000
21	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(2), CHKA(1), PDHA2(1), PEMT(1)	503543	5	5	5	1	3	1	1	0	0	0	0.312	0.122	1.000
22	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), JUNB(1), MAP2K3(2), NFATC1(2), NFATC2(2)	921502	9	9	9	3	3	2	2	1	1	0	0.410	0.122	1.000
23	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR171(1), GPR34(1), GPR39(1), GPR68(1), GPR75(1)	715879	6	5	6	0	1	2	2	0	1	0	0.112	0.134	1.000
24	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDHPPT(2), AASS(2)	502133	4	4	4	0	0	1	1	1	1	0	0.382	0.140	1.000
25	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCR3(1), IL5RA(1), IL6(2)	348096	4	3	4	1	1	1	1	1	0	0	0.546	0.164	1.000
26	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3D(1), CD3G(1)	235227	2	2	2	0	0	1	0	0	1	0	0.345	0.169	1.000
27	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(2), LRP8(1), RELN(5), VLDLR(2)	1008604	11	7	11	1	2	1	3	4	1	0	0.141	0.173	1.000
28	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA3(1), P2RY1(1), P2RY6(1)	424295	4	4	4	0	2	1	0	1	0	0	0.180	0.187	1.000
29	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(2)	248068	2	2	2	0	1	0	1	0	0	0	0.452	0.194	1.000
30	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CREBBP(6), EP300(3), IKBKB(2), MAP2K3(2), MAPK11(1), NFKB1(1), NFKBIA(3), TLR2(2), TNF(3)	2139291	23	19	23	6	4	1	4	8	6	0	0.327	0.203	1.000
31	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(1), ACE2(1), AGT(1), AGTR1(2), AGTR2(3), CMA1(1), CTSG(1), ENPEP(1), LNPEP(1), MME(2), NLN(2), THOP1(1)	1540715	17	11	17	2	3	1	2	9	2	0	0.129	0.211	1.000
32	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(1), ALDOC(1)	284076	2	2	2	0	1	0	1	0	0	0	0.500	0.211	1.000
33	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(1), E2F1(2), RB1(1)	618831	4	4	4	1	1	0	1	0	2	0	0.672	0.212	1.000
34	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2B5(2), EIF2S2(1), PPP1CA(1)	840952	6	5	6	1	2	0	1	2	1	0	0.461	0.213	1.000
35	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3D(1), CD3G(1), PTPRC(1), ZAP70(1)	632850	4	4	4	0	1	2	0	0	1	0	0.159	0.214	1.000
36	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), ALDOC(1), FBP2(2), MDH2(1), ME2(1), ME3(1)	1330472	7	7	7	1	3	1	1	2	0	0	0.250	0.219	1.000
37	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), GRM1(1), PLCB1(5), PPP1CA(1), PPP2CA(1), PPP3CA(1)	1180726	10	9	10	3	0	1	0	4	5	0	0.654	0.222	1.000
38	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CUL1(1), E2F1(2), RB1(1), SKP2(1)	626122	5	4	5	1	1	0	1	0	3	0	0.532	0.223	1.000
39	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CUL1(1), E2F1(2), RB1(1), SKP2(1)	635036	5	4	5	1	1	0	1	0	3	0	0.523	0.227	1.000
40	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD3D(1), CD3G(1), GRB2(1), PIK3CA(2)	890776	5	5	5	0	0	2	0	1	2	0	0.156	0.228	1.000
41	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(3), CAPN2(1), EP300(3), HDAC2(2), NFATC1(2), NFATC2(2), PPP3CA(1), PPP3CC(1)	1783310	15	10	15	2	5	0	3	5	2	0	0.108	0.237	1.000
42	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	PPARG(1), TNF(3)	416737	4	4	4	2	0	1	0	2	1	0	0.789	0.237	1.000
43	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	IL12B(2), IL12RB1(1), IL12RB2(2), IL2RA(1), IL4R(1)	882685	7	7	6	2	2	1	1	1	2	0	0.409	0.256	1.000
44	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(3), SNCAIP(1)	451128	4	4	4	1	0	0	0	4	0	0	0.811	0.258	1.000
45	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(1)	344273	2	2	2	1	1	1	0	0	0	0	0.745	0.264	1.000
46	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	120022	1	1	1	0	1	0	0	0	0	0	0.654	0.283	1.000
47	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1), SHMT1(1), SHMT2(1)	319924	3	3	3	1	1	1	0	1	0	0	0.658	0.297	1.000
48	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	CD3D(1), CD3G(1), CREBBP(6), CSK(3), GNAS(1), GNGT1(1), PTPRC(1), ZAP70(1)	1682668	15	12	15	4	4	2	2	3	4	0	0.370	0.314	1.000
49	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	CD3D(1), CD3G(1), CREBBP(6), CSK(3), GNAS(1), GNGT1(1), PTPRC(1), ZAP70(1)	1682668	15	12	15	4	4	2	2	3	4	0	0.370	0.314	1.000
50	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	GBA(2), TPO(4)	618695	6	4	6	2	2	0	2	1	1	0	0.582	0.322	1.000
51	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), TAT(1), TYR(2)	339632	4	4	4	2	3	1	0	0	0	0	0.681	0.338	1.000
52	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(8), ATR(2), CDC25C(2), CHEK2(2)	1080189	14	10	12	3	1	3	5	4	0	1	0.316	0.347	1.000
53	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CDK5R1(1), CSNK1A1(2), PPP2CA(1)	721733	4	4	4	1	0	1	0	1	2	0	0.567	0.358	1.000
54	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), IL6(2)	385027	3	2	3	1	1	0	1	1	0	0	0.648	0.362	1.000
55	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(3)	278637	3	3	3	2	0	0	0	2	1	0	0.954	0.364	1.000
56	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(1), FLAD1(1), TYR(2)	720331	4	4	4	1	1	1	1	1	0	0	0.559	0.386	1.000
57	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	KLRC4(1), MAP2K1(2), PIK3CA(2), PTPN6(4)	1315285	9	6	9	1	2	1	2	2	2	0	0.225	0.390	1.000
58	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1), SNAP25(1)	230341	2	2	2	0	0	0	0	1	1	0	0.471	0.397	1.000
59	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25C(2), CSK(3), GRB2(1), PTPRA(1)	678402	7	7	7	3	1	0	1	2	3	0	0.847	0.398	1.000
60	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), GGPS1(1)	320695	2	2	2	1	0	0	1	1	0	0	0.813	0.412	1.000
61	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), PTGS1(1), PTGS2(1)	381456	3	3	3	0	1	0	0	2	0	0	0.502	0.419	1.000
62	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS2(1), UROS(1)	568954	3	3	3	1	2	0	1	0	0	0	0.750	0.429	1.000
63	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADM(1)	400262	2	2	2	1	0	1	1	0	0	0	0.745	0.435	1.000
64	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	SPCS1(1)	225000	1	1	1	1	0	0	0	0	1	0	1.000	0.449	1.000
65	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(1), COASY(2), DPYD(3), DPYS(1), PANK2(1), PANK4(2), VNN1(3)	1282087	13	10	13	4	1	2	2	6	2	0	0.560	0.455	1.000
66	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	EIF2S2(1), NFKB1(1), NFKBIA(3)	688437	5	5	5	2	2	0	1	1	1	0	0.664	0.459	1.000
67	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCR3(1)	176118	1	1	1	0	0	0	0	1	0	0	0.825	0.460	1.000
68	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ITPKA(1), ITPKB(5)	444148	6	6	6	4	0	2	1	1	2	0	0.877	0.466	1.000
69	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(3), LDHA(1), LDHAL6A(2), SULT1C2(1)	922822	7	4	7	1	0	1	2	2	2	0	0.425	0.493	1.000
70	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP8(2)	276675	3	2	3	4	2	0	0	0	1	0	0.974	0.493	1.000
71	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(1)	191112	1	1	1	1	1	0	0	0	0	0	0.894	0.501	1.000
72	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(2), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), GPHN(1), UBQLN1(1)	932848	8	5	8	0	1	1	2	4	0	0	0.101	0.517	1.000
73	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(8), CDC25C(2), MYT1(1)	1014844	11	8	9	3	1	2	5	3	0	0	0.376	0.517	1.000
74	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	TPO(4), TYR(2)	716695	6	5	6	2	3	1	1	1	0	0	0.521	0.550	1.000
75	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), GLS(1)	430702	2	2	2	0	1	0	0	1	0	0	0.553	0.551	1.000
76	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(1), ACP6(1), FLAD1(1), MTMR1(3), PHPT1(1), TYR(2)	1116158	9	7	9	3	2	2	2	2	1	0	0.509	0.554	1.000
77	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(2), PLCB1(5)	939047	7	7	7	4	0	1	0	3	3	0	0.931	0.556	1.000
78	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2)	588587	5	4	5	2	1	2	0	1	1	0	0.608	0.559	1.000
79	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2)	588587	5	4	5	2	1	2	0	1	1	0	0.608	0.559	1.000
80	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1)	243414	1	1	1	1	0	0	1	0	0	0	0.887	0.564	1.000
81	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR2(2), CCR3(1), CXCR4(3), IL12B(2), IL12RB1(1), IL12RB2(2), IL4R(1), TGFB2(1)	1470755	13	11	12	3	3	3	1	5	1	0	0.276	0.564	1.000
82	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), CBS(2), MUT(1)	364148	4	3	4	2	2	0	1	1	0	0	0.747	0.564	1.000
83	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UXS1(1)	296956	1	1	1	0	0	1	0	0	0	0	0.645	0.566	1.000
84	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CREBBP(6), EP300(3), IKBKB(2), NFKB1(1), NFKBIA(3), TNF(3), TNFRSF1B(1), TRAF6(1)	1696262	20	17	20	8	4	2	3	6	5	0	0.644	0.575	1.000
85	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(2), TNF(3), TNFRSF1B(1)	611399	6	5	6	9	1	2	0	1	2	0	0.998	0.606	1.000
86	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	MTHFR(1), SHMT1(1), SHMT2(1), TPO(4)	846904	7	6	7	2	3	2	1	1	0	0	0.407	0.608	1.000
87	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(2), HSD3B7(1), PON1(2), PON2(1)	649246	6	6	6	2	1	0	0	5	0	0	0.770	0.622	1.000
88	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCL2(1), CXCR4(3), MAPK8(1)	987940	5	5	5	2	0	2	1	2	0	0	0.640	0.629	1.000
89	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1)	330026	1	1	1	1	0	0	0	1	0	0	0.942	0.643	1.000
90	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT3(1), FUT8(1), MAN1B1(1), MGAT1(2), MGAT4A(2), MGAT5(1), ST6GAL1(3)	1490312	11	7	11	3	2	3	2	4	0	0	0.379	0.652	1.000
91	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCS2(1), OXCT1(2)	555702	3	2	3	0	2	0	1	0	0	0	0.309	0.652	1.000
92	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(2), DPYD(3), DPYS(1), PANK2(1), PANK4(2)	1032407	9	9	9	4	1	2	2	3	1	0	0.747	0.657	1.000
93	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT3(1), FUT8(1)	568409	3	3	3	1	2	0	0	1	0	0	0.739	0.659	1.000
94	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CDKN2A(1), E2F1(2), E2F2(1), PRB1(1)	659154	5	4	5	3	1	1	1	0	2	0	0.848	0.661	1.000
95	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UXS1(1)	371833	1	1	1	0	0	1	0	0	0	0	0.652	0.664	1.000
96	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	HEMK1(1), LCMT1(1), LCMT2(1), PCYT1B(1), PRMT2(1), PRMT8(1)	1023131	6	5	6	2	2	2	1	1	0	0	0.502	0.669	1.000
97	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(4), NRG2(1), PSEN1(1)	663032	6	5	6	4	1	1	0	2	2	0	0.866	0.687	1.000
98	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(1), POLR2B(1), POLR2E(1), POLR3A(2)	1688473	8	7	8	1	1	0	4	3	0	0	0.305	0.687	1.000
99	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CSNK1E(1), PER1(1)	633431	2	2	2	0	1	0	0	0	1	0	0.722	0.690	1.000
100	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), CYP1A2(1), CYP2C19(1), CYP2C8(2), CYP2C9(1), CYP2J2(1), CYP3A4(1), CYP3A43(2), CYP3A5(3), HSD3B7(1), PLA2G4A(1), PLA2G5(1)	1787057	17	11	17	5	6	2	2	3	4	0	0.440	0.693	1.000
101	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADM(1), ACADVL(1), ACSL3(2), CPT2(1), EHHADH(2)	1226141	8	6	8	2	1	3	3	0	1	0	0.391	0.703	1.000
102	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(6), RB1(1), SIRT1(1), SP100(2), TNF(3), TNFRSF1B(1)	1338156	14	12	14	8	2	3	1	4	4	0	0.881	0.705	1.000
103	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(6), EP300(3), JAK1(2), JAK3(2), PIK3CA(2)	2069090	16	12	16	5	5	2	2	5	2	0	0.477	0.706	1.000
104	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1)	795943	7	5	7	3	3	2	0	1	1	0	0.616	0.713	1.000
105	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	IL6(2)	460993	2	1	2	1	1	0	1	0	0	0	0.765	0.717	1.000
106	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFS1(1), NDUFV2(1)	520163	2	2	2	0	1	1	0	0	0	0	0.473	0.727	1.000
107	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), ALDOC(1), FBP2(2), MDH2(1), ME3(1), PGK2(1)	1482453	7	7	7	2	3	1	1	2	0	0	0.448	0.728	1.000
108	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), EHHADH(2)	896625	7	4	7	2	1	2	2	1	1	0	0.440	0.728	1.000
109	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	GH1(1), GHR(1), NFKB1(1), NFKBIA(3), PDPK1(1), PIK3CA(2), PPP2CA(1)	1081965	10	8	10	6	1	3	1	2	3	0	0.859	0.728	1.000
110	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(3), ALG10(1), ALG11(1), ALG12(1), ALG14(2), ALG6(3), ALG9(1), B4GALT3(1), DOLPP1(1), FUT8(1), GANAB(2), MAN1A2(1), MAN1B1(1), MAN1C1(1), MGAT1(2), MGAT4A(2), MGAT5(1), MGAT5B(1), RFT1(1), ST6GAL1(3)	3152563	30	17	29	5	7	6	7	9	1	0	0.0497	0.749	1.000
111	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(4), ELK1(1), GRB2(1), MAP2K1(2), MAPK8(1), NGFR(2), PIK3CA(2), RAF1(4)	1403096	17	11	17	6	1	7	4	1	4	0	0.426	0.753	1.000
112	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT5(1)	370970	1	1	1	1	0	0	0	0	1	0	0.917	0.755	1.000
113	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B4GALT3(1), CHST2(1), CHST4(2), CHST6(1), FUT8(1)	890903	7	7	7	3	2	3	0	1	1	0	0.693	0.758	1.000
114	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(6), EP300(3), PELP1(2)	1122315	11	9	11	5	1	1	2	4	3	0	0.808	0.777	1.000
115	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	KEAP1(1), MAPK8(1)	680914	2	2	2	1	0	1	1	0	0	0	0.736	0.777	1.000
116	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	IFNA1(1), IKBKB(2), IL1A(1), IL1R1(1), IL6(2), IRAK2(1), MAP2K3(2), MAP3K1(3), MAPK8(1), NFKB1(1), NFKBIA(3), TGFB2(1), TNF(3), TRAF6(1)	2137046	23	17	22	9	8	1	6	3	5	0	0.502	0.782	1.000
117	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	CKM(1), LDHA(1), NCL(2)	663110	4	4	4	2	1	0	1	0	2	0	0.890	0.788	1.000
118	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	SHMT1(1), SHMT2(1), TPO(4)	872150	6	5	6	2	3	1	1	1	0	0	0.518	0.795	1.000
119	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(8), CDC25C(2), MYT1(1), RB1(1)	1234865	12	9	10	4	1	2	5	3	1	0	0.498	0.797	1.000
120	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ARHGEF1(1), F2R(1), GNA13(2), GNGT1(1), PIK3CA(2), PLCB1(5)	1892787	12	10	12	4	1	3	0	3	5	0	0.565	0.799	1.000
121	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), PLA2G4A(1), PLA2G5(1)	790092	5	3	5	0	3	0	1	1	0	0	0.189	0.801	1.000
122	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), MST1R(1), TNF(3)	468866	5	5	5	3	0	2	0	2	1	0	0.792	0.807	1.000
123	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	PAPSS1(1), SUOX(1)	613543	2	2	2	0	0	1	0	0	1	0	0.444	0.810	1.000
124	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(2), SDHC(1)	473181	3	3	3	5	0	1	0	1	1	0	0.995	0.811	1.000
125	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	14	CHST11(1), CHST12(2), PAPSS1(1), SULT1A1(2), SULT2B1(1), SUOX(1)	850793	8	5	8	2	0	1	1	4	2	0	0.625	0.811	1.000
126	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(2), ALOX15B(2), GGT1(1), LTA4H(2), PTGS1(1), PTGS2(1), TBXAS1(3)	1168123	12	8	12	4	3	0	1	6	2	0	0.687	0.812	1.000
127	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	CASP1(1), CASP8(2), PRF1(2)	925166	5	4	5	3	3	0	0	0	2	0	0.806	0.812	1.000
128	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	ELK1(1), IKBKB(2), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAPK8(1), NFKB1(1), NFKBIA(3), TIRAP(1), TLR2(2), TLR3(1), TLR4(2), TLR6(1), TRAF6(1)	2696002	22	16	21	7	5	1	7	6	3	0	0.374	0.815	1.000
129	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(1), MAP2K1(2), NGFR(2), RAF1(4)	621918	10	7	10	7	1	3	3	1	2	0	0.894	0.821	1.000
130	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), JAK1(2), PTPRU(1), STAT1(1), STAT2(1), TYK2(1)	918688	7	6	7	3	2	2	0	2	1	0	0.677	0.824	1.000
131	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), GBGT1(2), NAGA(1)	731897	4	4	3	5	0	0	1	1	2	0	0.988	0.827	1.000
132	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(1), GLS(1)	565382	2	1	2	2	0	0	0	1	1	0	0.954	0.829	1.000
133	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), EHHADH(2)	617928	3	2	3	1	0	0	3	0	0	0	0.582	0.833	1.000
134	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2R(1), GNGT1(1), MAP2K1(2), PLA2G4A(1), PLCB1(5), PTGS1(1), PTK2(1), RAF1(4), TBXAS1(3)	1779098	19	13	19	7	3	4	3	6	3	0	0.664	0.836	1.000
135	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP68(1), SRP72(1), SRPR(1)	542736	3	3	3	2	2	0	0	1	0	0	0.875	0.839	1.000
136	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	LDHA(1)	493188	1	1	1	0	0	0	1	0	0	0	0.700	0.846	1.000
137	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(3)	586001	3	2	3	2	0	0	1	2	0	0	0.879	0.846	1.000
138	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(1), IL1A(1), IL6(2), KITLG(1), TGFB2(1)	631490	6	5	6	3	4	0	1	1	0	0	0.687	0.846	1.000
139	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), GBGT1(2), NAGA(1)	775409	4	4	3	5	0	0	1	1	2	0	0.989	0.848	1.000
140	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	29	EDNRA(1), HPGD(1), PLA2G4A(1), PTGFR(1), PTGIR(2), PTGS1(1), PTGS2(1), TBXAS1(3)	1618270	11	7	11	3	2	0	2	7	0	0	0.563	0.849	1.000
141	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST6GALNAC2(1)	409943	1	1	1	1	1	0	0	0	0	0	0.926	0.852	1.000
142	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDFT1(1), HMGCR(1), LSS(2), NSDHL(1)	977112	6	4	6	2	2	2	1	1	0	0	0.492	0.853	1.000
143	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	POLG(1), RRM1(1), SRM(1)	957892	3	3	3	1	0	1	1	1	0	0	0.674	0.853	1.000
144	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(1), EP300(3), LDHA(1)	1247726	5	4	5	2	1	0	2	2	0	0	0.700	0.854	1.000
145	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP6(2), ARHGEF1(1), ARHGEF11(2), ARHGEF5(1), GSN(1), LIMK1(1), MYLK(3), PFN1(3), PIP5K1A(1), TLN1(3)	3532824	18	13	18	3	6	2	3	5	2	0	0.104	0.858	1.000
146	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), HSD3B2(2)	502862	3	2	3	2	1	1	1	0	0	0	0.753	0.862	1.000
147	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(6), EP300(3), NCOA3(2)	1523791	11	10	11	5	1	1	2	4	3	0	0.802	0.865	1.000
148	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(2)	356381	2	1	2	0	0	0	2	0	0	0	0.470	0.866	1.000
149	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1)	444881	1	1	1	0	1	0	0	0	0	0	0.695	0.868	1.000
150	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSB(1), PAH(1), TAT(1)	632714	3	3	3	3	1	0	0	1	1	0	0.957	0.869	1.000
151	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1)	455083	1	1	1	1	1	0	0	0	0	0	0.941	0.877	1.000
152	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), ELK1(1), GRB2(1), IL2RA(1), JAK1(2), JAK3(2), MAP2K1(2), MAPK8(1), RAF1(4)	1768450	18	13	18	6	4	7	3	0	4	0	0.328	0.878	1.000
153	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1)	636551	1	1	1	4	0	0	0	0	1	0	0.997	0.880	1.000
154	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CSNK1E(1), NPAS2(1), PER1(1), PER2(1), PER3(3)	1266817	7	6	7	3	2	2	0	2	1	0	0.761	0.882	1.000
155	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(2), ABCC1(2), ABCC3(2)	1054274	6	5	6	5	2	0	2	0	2	0	0.965	0.882	1.000
156	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMB2(1)	639812	1	1	1	1	0	0	0	0	1	0	1.000	0.886	1.000
157	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), GAD1(2), GAD2(1), GGT1(1)	428172	5	4	5	3	2	1	0	2	0	0	0.820	0.886	1.000
158	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(3), ELOVL6(1), FASN(1)	1132589	6	5	6	2	2	0	1	3	0	0	0.604	0.888	1.000
159	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(2), ATM(8), CDKN1A(2), CSNK1A1(2), MAPK8(1), NFKBIB(1), NQO1(1)	1531410	17	12	15	6	3	4	6	2	2	0	0.454	0.888	1.000
160	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(2), ABCC2(1), CYP3A4(1), CYP3A5(3), UGT1A10(1)	1661311	8	7	8	6	2	1	1	0	4	0	0.909	0.888	1.000
161	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPP(2), ALPPL2(1), FPGS(1), GCH1(1)	518717	5	5	5	5	3	0	1	0	1	0	0.901	0.889	1.000
162	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA3(1), CA9(1), CPS1(1), GLS(1)	1378211	5	4	5	3	0	1	0	1	3	0	0.949	0.892	1.000
163	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(2), GGT1(1), PAPSS1(1)	916094	4	3	4	1	0	0	1	2	1	0	0.667	0.893	1.000
164	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(1), GRB2(1), ILK(1), PDPK1(1), PIK3CA(2), PTEN(2), PTK2(1)	1450523	9	8	9	6	2	1	0	3	3	0	0.914	0.894	1.000
165	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GNT5(2)	522310	2	1	2	1	0	1	1	0	0	0	0.816	0.895	1.000
166	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2B(1), POLR2E(1), POLRMT(3)	997709	6	4	6	3	0	2	2	2	0	0	0.735	0.896	1.000
167	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ALDH1A3(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(2), EHHADH(2), GAD1(2), GAD2(1), OXCT1(2), PDHA2(1)	1892140	14	10	14	5	3	3	4	2	2	0	0.502	0.897	1.000
168	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(1), AGTR1(2), AGTR2(3), CMA1(1), COL4A1(1), COL4A3(1), COL4A4(2), COL4A5(1)	1880144	13	11	13	5	2	1	0	7	3	0	0.739	0.898	1.000
169	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	HDAC9(1), MEF2B(3)	634155	4	4	3	4	0	1	0	2	1	0	0.989	0.900	1.000
170	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	C9orf47(1), MTNR1A(2), MTNR1B(2), PTAFR(1), PTGFR(1), PTGIR(2)	848418	9	7	9	3	2	1	3	3	0	0	0.513	0.904	1.000
171	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CDKN1A(2), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(1), PPP3CC(1)	1502460	10	7	10	3	4	1	2	2	1	0	0.390	0.908	1.000
172	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKB(2), MAP3K1(3), NFKB1(1), NFKBIA(3), TRAF6(1)	1281025	10	8	9	6	3	0	3	2	2	0	0.895	0.908	1.000
173	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IL12B(2), IL16(1), IL1A(1), IL6(2), LTA(1), TNF(3)	716613	11	9	10	5	7	1	1	1	1	0	0.537	0.910	1.000
174	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	8	CD3D(1), CD3G(1), PRF1(2)	556095	4	3	4	4	2	1	0	0	1	0	0.864	0.911	1.000
175	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(3), BCAR1(1), CSK(3), CTNNA2(2), PTK2(1)	1433513	10	7	8	3	2	0	2	5	1	0	0.642	0.912	1.000
176	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), PAH(1), TAT(1)	595778	3	3	3	2	1	0	0	2	0	0	0.890	0.914	1.000
177	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHB1(1), L1CAM(1), LYN(2)	1140399	4	4	3	2	2	0	2	0	0	0	0.812	0.916	1.000
178	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	MBTPS1(1), SREBF1(1), SREBF2(1)	931385	3	3	3	1	1	0	1	1	0	0	0.686	0.917	1.000
179	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), THBS1(1)	517679	2	1	2	4	0	0	0	1	1	0	0.996	0.919	1.000
180	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2)	631532	5	4	5	4	1	2	0	1	1	0	0.896	0.924	1.000
181	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(1), HGSNAT(1), HPSE(1), HPSE2(3), IDS(1), LCT(1), NAGLU(3)	1543835	11	6	11	3	4	2	0	5	0	0	0.423	0.925	1.000
182	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	NFKB1(1), TNF(3)	738471	4	4	4	8	0	1	1	1	1	0	0.999	0.927	1.000
183	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A2(1), EIF4G1(1), EIF4G2(1), EIF4G3(1), GHR(1), MKNK1(1), PABPC1(5), PDPK1(1), PIK3CA(2), PTEN(2)	2077640	16	9	16	9	1	1	1	8	5	0	0.946	0.930	1.000
184	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	GNAS(1), XPO1(2)	704071	3	3	3	2	2	0	0	1	0	0	0.878	0.931	1.000
185	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS2(1), UROS(1)	621764	3	3	3	2	2	0	1	0	0	0	0.897	0.931	1.000
186	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), CA13(1), CA3(1), CA9(1), CPS1(1), GLS(1)	1540055	6	4	6	4	0	1	1	1	3	0	0.950	0.933	1.000
187	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA2(1), LCT(1), MANBA(1), NEU2(1)	1250472	6	5	6	3	0	4	1	0	1	0	0.589	0.934	1.000
188	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCND2(1), CCND3(2), CDKN1A(2), CDKN2A(1), CDKN2B(1), E2F1(2), RB1(1)	1174635	10	10	10	8	3	3	2	0	2	0	0.945	0.935	1.000
189	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	DFFA(1), ENDOG(2), HMGB2(1), TOP2B(1)	775933	5	4	5	4	0	1	1	2	1	0	0.976	0.936	1.000
190	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3B1(1), XYLT1(2), XYLT2(1)	514100	5	3	4	3	1	1	0	2	1	0	0.677	0.936	1.000
191	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3B1(1), XYLT1(2), XYLT2(1)	514100	5	3	4	3	1	1	0	2	1	0	0.677	0.936	1.000
192	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	ATM(8), BCL2(1), CDKN1A(2), E2F1(2), RB1(1)	1261450	14	11	12	8	3	3	5	1	2	0	0.832	0.936	1.000
193	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	CS(2), PC(1)	672578	3	2	3	2	0	0	0	3	0	0	0.886	0.937	1.000
194	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(8), ATR(2), BRCA1(2), CDC25C(2), CDKN1A(2), CHEK2(2), EP300(3), MYT1(1)	3083407	22	14	20	6	2	6	6	7	0	1	0.319	0.937	1.000
195	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12B(1), ALOX15(2), ALOX15B(2), CYP2B6(1), CYP2C19(1), CYP2C8(2), CYP2C9(1), CYP2J2(1), CYP4A22(1), CYP4F3(1), DHRS4(2), EPHX2(1), GGT1(1), GPX5(1), LTA4H(2), PLA2G4A(1), PLA2G5(1), PTGES2(1), PTGS1(1), PTGS2(1), TBXAS1(3)	2960201	30	16	29	7	8	2	8	10	2	0	0.248	0.937	1.000
196	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CD3G(1), ETV5(1), IL12B(2), IL12RB1(1), IL12RB2(2), JAK2(2), MAPK8(1), TYK2(1)	1381689	12	10	11	6	2	2	1	4	3	0	0.780	0.941	1.000
197	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	12	IL10RA(2), IL1A(1), IL6(2), JAK1(2), STAT1(1), TNF(3)	779760	11	7	11	7	4	3	1	2	1	0	0.807	0.941	1.000
198	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), GNAS(1), GNGT1(1), LIMK1(1), MAP2K1(2), PIK3C2G(5), PLCB1(5), PTK2(1), RAF1(4)	1878938	21	15	21	9	4	3	3	8	3	0	0.864	0.943	1.000
199	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	CFTR(2), GNAS(1)	971932	3	2	3	5	1	0	0	0	2	0	0.999	0.944	1.000
200	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IKBKB(2), MAP3K1(3), MAP4K5(1), MAPK8(1), NFKB1(1), NFKBIA(3)	1462264	11	9	10	6	2	0	5	2	2	0	0.839	0.945	1.000
201	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), CASP1(1), CASP8(2), INSR(1), ITCH(1), MAGI1(3), MAGI2(4), RERE(2), WWP2(1)	1743666	16	13	15	9	1	5	1	6	3	0	0.852	0.945	1.000
202	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(2), HEMK1(1), LCMT1(1), LCMT2(1), PRMT2(1), PRMT8(1)	1089110	7	6	7	3	2	2	1	2	0	0	0.674	0.945	1.000
203	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(3), RAF1(4), SNX13(1)	848206	9	8	9	5	0	4	3	1	1	0	0.744	0.946	1.000
204	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	GRB2(1), IL3RA(1), JAK2(2), MAP2K1(2), PTPN6(4), RAF1(4)	1314470	14	9	14	9	2	3	3	4	2	0	0.902	0.947	1.000
205	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ACADM(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), CNDP1(2), DPYD(3), DPYS(1), EHHADH(2), GAD1(2), GAD2(1), SRM(1)	1960112	19	12	19	6	4	4	4	6	1	0	0.386	0.949	1.000
206	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), CNDP1(2), DDC(1), HDC(1)	1797143	10	8	10	3	4	2	1	2	1	0	0.369	0.950	1.000
207	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	CD33(3), IFNA1(1), IL12B(2), TLR2(2), TLR4(2)	1349278	10	7	9	4	3	1	3	3	0	0	0.673	0.957	1.000
208	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(1), IDS(1), LCT(1), NAGLU(3)	1077485	6	3	6	1	3	1	0	2	0	0	0.301	0.957	1.000
209	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	19	PSMB2(1)	945874	1	1	1	1	0	0	0	0	1	0	1.000	0.959	1.000
210	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	NT5C(1), NT5M(1)	1071560	2	2	2	1	2	0	0	0	0	0	0.707	0.959	1.000
211	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(4), ELK1(1), GRB2(1), MAP2K1(2), MAPK8(1), PIK3CA(2), RAF1(4)	1814064	15	10	15	8	1	7	3	1	3	0	0.804	0.962	1.000
212	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3D(1), CD3G(1), PTPRC(1)	767381	3	3	3	2	0	2	0	0	1	0	0.703	0.962	1.000
213	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	BCL2(1), BIRC2(1), CASP8(2), DFFA(1), ENDOG(2)	991943	7	5	7	8	2	1	1	2	1	0	0.993	0.962	1.000
214	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX15(2), CYP4F3(1), GGT1(1), LTA4H(2), PLA2G4A(1), PLA2G5(1), PTGES2(1), PTGS1(1), PTGS2(1), TBXAS1(3), TPO(4)	2096266	20	13	20	6	6	0	6	7	1	0	0.522	0.963	1.000
215	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V1G3(1), SHMT1(1)	1106699	5	3	5	2	2	1	1	1	0	0	0.637	0.964	1.000
216	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V1G3(1), SHMT1(1)	1106699	5	3	5	2	2	1	1	1	0	0	0.637	0.964	1.000
217	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V1G3(1), SHMT1(1)	1106699	5	3	5	2	2	1	1	1	0	0	0.637	0.964	1.000
218	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	BIRC2(1), CASP1(1), CASP4(2), CASP8(2), DFFA(1), PRF1(2)	1424390	9	6	9	8	4	0	1	2	2	0	0.980	0.965	1.000
219	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADL(1), ACADM(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), CNDP1(2), DPYD(3), DPYS(1), EHHADH(2), GAD1(2), GAD2(1)	2109652	19	12	19	6	4	5	4	5	1	0	0.340	0.965	1.000
220	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(1), GRB2(1), ILK(1), PIK3CA(2), PIK3CD(1), PTEN(2)	1478442	8	7	8	4	3	1	0	2	2	0	0.741	0.966	1.000
221	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(2), EPOR(1), JAK2(2), NFKB1(1), NFKBIA(3)	967345	9	6	9	6	2	1	1	4	1	0	0.887	0.966	1.000
222	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2A1(1), GTF2F1(3), NCOA1(1), NCOA2(1), NCOA3(2), NCOR2(4), TBP(1)	1867153	13	8	13	6	2	4	2	2	3	0	0.722	0.967	1.000
223	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	GH1(1), GHR(1), PIK3CA(2)	960523	4	4	4	8	0	2	0	1	1	0	0.997	0.967	1.000
224	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3D(1), CD3G(1), PTPRC(1)	809519	3	3	3	2	0	2	0	0	1	0	0.702	0.968	1.000
225	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GPRC5C(2), GRM1(1), GRM2(1), GRM4(1), GRM5(1), GRM8(1)	1515042	9	6	9	4	3	1	1	4	0	0	0.707	0.968	1.000
226	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(1), GLI2(2), GLI3(1), SHH(1), SMO(1)	1223834	8	7	8	9	2	1	1	2	2	0	0.993	0.968	1.000
227	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(3), C5(2), C6(3), C7(1), C8A(1)	926345	10	6	10	5	2	4	1	2	1	0	0.718	0.968	1.000
228	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(4), ELK1(1), GRB2(1), INSR(1), MAP2K1(2), MAPK8(1), PIK3CA(2), RAF1(4), SLC2A4(1)	1871350	17	10	17	9	2	8	3	1	3	0	0.783	0.968	1.000
229	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	EHHADH(2)	570606	2	1	2	0	0	0	2	0	0	0	0.465	0.968	1.000
230	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT4(1), B3GNT5(2), B4GALT3(1), FUT4(1), FUT5(1)	1175531	7	5	7	3	3	1	2	0	1	0	0.616	0.969	1.000
231	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK2(1), HK3(1), PGM3(1)	766618	3	3	3	4	1	1	0	0	1	0	0.975	0.969	1.000
232	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(1), CD3G(1), IL12B(2), IL12RB1(1), IL12RB2(2), JAK2(2), TYK2(1)	1100637	10	8	9	6	2	2	0	4	2	0	0.869	0.970	1.000
233	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	IFNA1(1), IL12B(2), IL1A(1), IL6(2), LTA(1), TGFB2(1), TNF(3)	968468	11	9	10	5	7	1	1	1	1	0	0.542	0.970	1.000
234	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	UGT1A10(1), UGT2B11(1), UGT2B17(2), UGT2B7(2)	1851875	6	5	6	3	1	1	1	0	3	0	0.747	0.971	1.000
235	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(1), ACACB(6), FASN(1)	1217851	8	6	7	3	5	1	1	1	0	0	0.601	0.972	1.000
236	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(1), HMGCR(1), LSS(2), NQO1(1)	823173	6	4	6	3	2	2	1	1	0	0	0.641	0.973	1.000
237	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(2), ATP6V0A4(1), ATP6V1G3(1), SHMT1(1)	1175640	5	3	5	2	2	1	1	1	0	0	0.638	0.974	1.000
238	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(3), PPP1CA(1), PPP2CA(1)	1224276	5	5	5	3	0	1	0	4	0	0	0.911	0.974	1.000
239	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2R(1), F5(1), F7(1), FGG(1), PROC(1)	1207552	6	5	6	3	3	1	1	1	0	0	0.756	0.978	1.000
240	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(2), EIF2S2(1), PDPK1(1), PIK3CA(2), PPP2CA(1), PTEN(2)	1483847	9	8	9	6	2	2	0	3	2	0	0.921	0.979	1.000
241	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(1), CD44(1), FCGR3A(1), TGFB2(1), TNF(3), TNFRSF1B(1), TNFRSF8(1)	1024926	9	9	9	6	1	4	0	3	1	0	0.842	0.979	1.000
242	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), FUCA2(1), GALNS(1), GBA(2), HGSNAT(1), HPSE(1), HPSE2(3), IDS(1), LCT(1), MAN2B1(1), MAN2B2(2), MANBA(1), NAGLU(3), NEU2(1)	2626601	21	10	21	8	5	5	2	7	2	0	0.495	0.980	1.000
243	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMB2(1)	1168763	1	1	1	1	0	0	0	0	1	0	1.000	0.982	1.000
244	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2)	978665	5	4	5	5	1	2	0	1	1	0	0.949	0.982	1.000
245	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	GRB2(1), NTRK1(1), PIK3CA(2)	1141683	4	4	4	8	1	1	0	1	1	0	0.998	0.983	1.000
246	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(1), IL4R(1), JAK1(2), JAK3(2), STAT6(4)	1084453	10	6	10	7	3	2	3	1	1	0	0.869	0.983	1.000
247	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLE(2), POLG(1), POLQ(6)	1233070	9	7	9	4	0	3	1	5	0	0	0.753	0.983	1.000
248	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK2(1), HK3(1), IMPA2(1), PGM3(1)	877141	4	4	4	6	1	2	0	0	1	0	0.984	0.985	1.000
249	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK2G(1), CAMK4(1), MEF2B(3), PPP3CA(1), PPP3CC(1), SLC2A4(1)	1563287	8	6	7	7	1	1	1	3	2	0	0.976	0.987	1.000
250	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(2)	1280246	2	2	2	1	0	0	1	1	0	0	0.844	0.990	1.000
251	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(3), CDH1(1), CREBBP(6), EP300(3), MAP2K1(2), TGFB2(1)	1878924	16	11	16	9	4	1	3	6	2	0	0.919	0.990	1.000
252	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(1), PAPSS1(1), PRMT2(1), PRMT8(1)	1834106	9	7	9	3	2	2	2	2	1	0	0.500	0.991	1.000
253	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(1), AOC2(1), DDC(1), TAT(1), TPO(4)	1626548	8	8	8	4	5	0	1	1	1	0	0.677	0.992	1.000
254	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	MUSK(3), PIK3CA(2), PTK2(1)	1234919	6	5	6	5	1	1	0	3	1	0	0.953	0.992	1.000
255	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	IL10RA(2), IL22RA2(2), JAK1(2), JAK2(2), JAK3(2), SOCS3(1), STAT1(1), TYK2(1)	1284880	13	11	13	9	4	3	1	4	1	0	0.942	0.993	1.000
256	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC2(1), CASP8(2), DFFA(1), PRF1(2), SREBF1(1), SREBF2(1)	1391676	8	6	8	5	4	0	2	1	1	0	0.885	0.993	1.000
257	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(3), PIK3CA(2), PLD1(1), RALBP1(1), TRIO(3), WASF1(1)	2554515	16	12	15	5	6	1	4	4	1	0	0.427	0.994	1.000
258	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	CKM(1), CPS1(1), OTC(1)	1372499	3	3	3	4	2	0	0	0	1	0	0.976	0.994	1.000
259	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(1), MAP2K1(2), PIK3CA(2), RAF1(4)	1373965	9	6	9	9	1	4	2	1	1	0	0.970	0.994	1.000
260	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT2(1), BTK(2), CDKN2A(1), GRB2(1), PIK3CA(2), PTEN(2), SFN(2), SOS2(1)	2627883	12	10	12	7	1	3	2	3	3	0	0.826	0.994	1.000
261	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	BST1(1), NT5C(1), NT5C1B(1), NT5M(1), NUDT12(1)	1583122	5	3	5	2	2	0	2	0	1	0	0.625	0.995	1.000
262	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CBS(2), SRM(1), TAT(1)	1528170	4	3	4	2	1	0	1	2	0	0	0.794	0.995	1.000
263	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	BTK(2), EEA1(1), LYN(2), PDPK1(1)	1820945	6	5	5	9	2	1	1	0	2	0	0.996	0.996	1.000
264	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	CDC16(2), CDC27(2), CUL1(1), FZR1(1), ITCH(1), SKP1(1), SKP2(1), SMURF1(1), SMURF2(1), UBA1(1), UBE2D3(1), WWP2(1)	3026471	14	14	14	8	2	2	3	3	4	0	0.901	0.996	1.000
265	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(1), EXTL3(1), HS3ST1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(2), HS6ST2(1), HS6ST3(1), NDST1(1), NDST3(1)	1549052	12	9	12	5	2	1	3	4	2	0	0.711	0.996	1.000
266	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	GAL3ST1(1), GBA(2), LCT(1), NEU2(1), SMPD2(1)	1799739	6	4	6	5	1	1	2	0	2	0	0.936	0.996	1.000
267	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP25(1), STX16(1), TSNARE1(1)	1245829	3	3	3	4	1	0	1	0	1	0	0.966	0.996	1.000
268	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), AMT(1), MTHFR(1), SHMT1(1), SHMT2(1)	1303963	5	5	5	3	1	3	0	1	0	0	0.749	0.997	1.000
269	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(1), GFPT1(1), HK2(1), HK3(1), PGM3(1)	1258083	5	4	5	6	2	1	0	1	1	0	0.985	0.997	1.000
270	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), EPHB2(1), MAPK7(1), MAPK8(1), PLD1(1), PLD2(2), PTK2(1), RAF1(4)	2044240	13	10	13	7	2	4	3	2	2	0	0.749	0.997	1.000
271	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA2(1), LCT(1), MAN2B1(1), MAN2B2(2), MANBA(1), NEU2(1)	1540625	9	6	9	5	1	4	1	2	1	0	0.734	0.997	1.000
272	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	EIF4G2(1), ETV6(1), MYF6(1), NCKAP1(1), PER1(1), PER2(1), PIGF(1), UCP3(1)	2669205	8	7	8	6	3	2	0	1	1	1	0.876	0.998	1.000
273	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(3), INSR(1), MAPK7(1), MEF2B(3), NFATC1(2), NFATC2(2), PIK3CA(2), PPP3CA(1), PPP3CC(1)	2582756	16	11	15	8	4	3	2	4	3	0	0.721	0.998	1.000
274	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A3(1), COL4A4(2), COL4A5(1), SLC23A1(1)	1889149	6	6	6	7	1	1	0	2	2	0	0.994	0.998	1.000
275	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(8), ATR(2), BRCA1(2), BRCA2(2), CHEK2(2), FANCA(1), FANCD2(2), FANCE(1), FANCG(1), HUS1(1), RAD50(1)	3119235	23	15	21	8	4	5	6	5	2	1	0.595	0.998	1.000
276	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), AMT(1), MTHFR(1), SHMT1(1), SHMT2(1)	1405984	5	5	5	3	1	3	0	1	0	0	0.747	0.998	1.000
277	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	GGT1(1), GPX5(1), GSTA3(2), GSTA4(1), IDH1(1), PGD(1)	1369233	7	6	7	4	1	2	2	2	0	0	0.777	0.998	1.000
278	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(3), EEF1B2(1), EIF2AK1(1), EIF2AK3(2), EIF2B3(2), EIF2B4(2), EIF2B5(2), EIF2S2(1), EIF4A2(1), EIF4G1(1), EIF4G3(1), PABPC1(5), PABPC3(1)	3271411	23	14	23	8	2	1	5	10	5	0	0.599	0.998	1.000
279	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), CPS1(1), OTC(1), SRM(1)	2171687	10	8	10	8	3	2	0	3	2	0	0.957	0.998	1.000
280	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT2(1), BCL10(1), BTK(2), CD22(1), CD79A(2), CR2(1), FCGR2B(1), IKBKB(2), LILRB3(4), LYN(2), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(1), NFKB2(3), NFKBIA(3), NFKBIB(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PTPN6(4), VAV3(1)	5268389	46	23	45	14	13	6	7	13	7	0	0.213	0.998	1.000
281	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	PGAP1(1), PIGB(1), PIGC(1), PIGF(1), PIGL(1), PIGP(1), PIGS(1), PIGW(2), PIGZ(1)	1820298	10	8	10	5	1	0	3	5	1	0	0.792	0.999	1.000
282	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	FBP2(2), GAA(1), GALK2(1), GANAB(2), HK2(1), HK3(1), LALBA(1), LCT(1), MGAM(7), PGM3(1)	2384083	18	10	17	9	3	3	4	5	3	0	0.838	0.999	1.000
283	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ALDH1A3(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(2), EHHADH(2), GAD1(2), GAD2(1), HMGCS2(1), HSD17B4(1), HSD3B7(1), OXCT1(2), PDHA2(1), PLA1A(2)	3021343	20	11	20	8	5	4	6	3	2	0	0.542	0.999	1.000
284	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(1), ENPP2(3), PLA2G4A(1), PLA2G5(1), PLD1(1), PLD2(2)	1736404	10	7	10	8	6	1	1	1	1	0	0.948	0.999	1.000
285	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS2(1), CP(1), UGT1A10(1), UGT2B11(1), UGT2B17(2), UGT2B7(2), UROS(1)	2938763	10	7	10	6	4	1	2	0	3	0	0.848	0.999	1.000
286	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	IFNA1(1), IFNA10(2), IFNA13(1), IFNA17(1), IFNA4(1), IFNA5(1), PRKAA1(1), ULK1(1), ULK2(1), ULK3(1)	1574589	11	7	11	9	3	2	2	3	1	0	0.943	0.999	1.000
287	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAP2K4(1), MAPK11(1), MAPK8(1), MAPK8IP1(1), NFKB1(1), NFKB2(3), NFKBIA(3), NFKBIB(1), PIK3CA(2), PIK3CD(1), TRAF6(1)	2611810	17	12	17	7	6	3	3	4	1	0	0.593	0.999	1.000
288	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), ALDH5A1(1), CAD(1), CPS1(1), GAD1(2), GAD2(1), GFPT1(1), GLS(1), GMPS(1), QARS(1)	2439238	11	8	11	6	4	1	0	3	3	0	0.879	0.999	1.000
289	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), AKR1C4(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), BAAT(1), CEL(1)	1704298	9	7	9	7	3	3	1	1	1	0	0.889	0.999	1.000
290	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	BIN1(1), PPP3CA(1), PPP3CC(1), SYNJ2(2)	1686103	5	4	5	5	1	1	1	0	2	0	0.951	1.000	1.000
291	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1S(3), C3(3), C4A(2), C5(2), C6(3), C7(1), C8A(1), MASP2(2), MBL2(1)	2551455	18	10	18	7	5	5	1	6	1	0	0.541	1.000	1.000
292	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	GGT1(1), GPX5(1), GSTA3(2), GSTA4(1), IDH1(1), OPLAH(2)	1693654	8	5	8	4	2	1	3	2	0	0	0.741	1.000	1.000
293	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2F1(3), TAF1(2), TAF1L(1), TAF4(1), TAF5L(2), TAF6(1), TAF6L(1), TAF7L(3)	2721143	15	7	15	5	2	3	1	6	3	0	0.645	1.000	1.000
294	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(1), ACADL(1), ACADM(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), EHHADH(2), LDHA(1), MCEE(1), MUT(1), PCCA(1), PCCB(1), SUCLG2(1)	2418125	16	8	16	7	2	4	6	2	2	0	0.646	1.000	1.000
295	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1D(2), ADRA2C(1), ADRB1(1), CHRM3(4), HTR1B(1), HTR2A(2), HTR4(1), HTR7(1)	1909000	13	11	13	7	2	1	2	7	1	0	0.916	1.000	1.000
296	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(1), ALDOC(1), FBP2(2), FPGT(1), HK2(1), HK3(1), PMM2(1)	1774868	8	8	8	8	2	1	1	3	1	0	0.974	1.000	1.000
297	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDHPPT(2), AASS(2), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), EHHADH(2), EHMT1(1), EHMT2(1), PLOD1(1), PLOD2(2), SHMT1(1), SHMT2(1)	2719521	18	12	18	8	3	4	5	4	2	0	0.678	1.000	1.000
298	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1S(3), C3(3), C4A(2), C5(2), C6(3), C7(1), C8A(1)	2264301	15	9	15	7	3	5	1	5	1	0	0.686	1.000	1.000
299	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), ALDH5A1(1), CAD(1), CPS1(1), GAD1(2), GAD2(1), GFPT1(1), GLS(1), GMPS(1), QARS(1)	2892271	11	8	11	7	4	1	0	3	3	0	0.922	1.000	1.000
300	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1S(3), C3(3), C4A(2), C5(2), C6(3), C7(1), C8A(1), C8B(1)	2500893	16	9	16	7	3	5	1	6	1	0	0.655	1.000	1.000
301	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	GSN(1), MAP2K1(2), MYLK(3), PFN1(3), PIK3CA(2), PTK2(1), RAF1(4), TLN1(3)	2752225	19	14	19	8	4	6	3	5	1	0	0.612	1.000	1.000
302	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	ILK(1), POLR1A(3), POLR1B(1), POLR2B(1), POLR2E(1), TAF6(1), TBP(1)	2586925	9	8	9	6	2	0	3	3	1	0	0.960	1.000	1.000
303	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), CYP2C19(1), CYP2C9(1), DHRS2(2), EHHADH(2)	2253090	11	8	11	9	2	3	2	3	1	0	0.959	1.000	1.000
304	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(1), AOC2(1), DDC(1), TAT(1), TPO(4)	2500214	8	8	8	7	5	0	1	1	1	0	0.924	1.000	1.000
305	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(1), CD3D(1), CSK(3), EPHB2(1), GRAP2(1), GRB2(1), ITPKA(1), ITPKB(5), LCP2(1), NFKB1(1), NFKB2(3), NFKBIA(3), NFKBIB(1), PAK4(2), PAK6(1), PAK7(2), PTPRC(1), RAF1(4), SOS2(1), ZAP70(1)	4182020	35	24	35	11	9	12	5	4	5	0	0.220	1.000	1.000
306	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), DLAT(1), GLO1(1), GRHPR(4), LDHA(1), MDH2(1), ME2(1), ME3(1), PC(1), PDHA2(1)	2693336	18	13	18	9	4	4	3	6	1	0	0.774	1.000	1.000
307	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLD3(1), POLE(2), POLG(1), POLM(1), POLQ(6), REV1(1), REV3L(3), RFC5(1)	3042921	16	12	16	9	2	5	1	7	1	0	0.878	1.000	1.000
308	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP6V0A1(2), ATP6V0A4(1), ATP6V1G3(1), COX7B(1), NDUFS1(1), NDUFV2(1), PPA2(1), SHMT1(1), UQCRH(1)	2813214	11	6	11	9	3	2	2	3	1	0	0.971	1.000	1.000
309	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), CNDP1(2), DDC(1), HDC(1), HEMK1(1), LCMT1(1), LCMT2(1), PRMT2(1), PRMT8(1)	2933698	15	10	15	8	6	4	2	2	1	0	0.701	1.000	1.000
310	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(1), ACADM(1), ACOX1(3), ACOX2(1), ACSL3(2), ACSL5(1), ADIPOQ(2), ANGPTL4(2), APOA1(1), CD36(1), CPT1C(1), CPT2(1), CYP4A22(1), CYP8B1(1), EHHADH(2), FABP7(1), HMGCS2(1), ILK(1), PCK2(1), PDPK1(1), PPARG(1), SLC27A1(1), SLC27A5(4), SLC27A6(1)	4804945	34	16	34	12	12	6	8	6	2	0	0.411	1.000	1.000
311	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	191	ACTB(5), ACTN1(3), ACTN4(1), AKT2(1), BCAR1(1), BCL2(1), BIRC2(1), BRAF(3), CAPN2(1), CAV1(1), CCND2(1), CCND3(2), CHAD(1), COL11A1(4), COL1A2(1), COL2A1(1), COL3A1(2), COL4A1(1), COL4A4(2), COL5A1(2), COL5A2(2), COL5A3(1), COL6A1(1), COL6A2(3), COL6A3(2), COL6A6(1), COMP(1), DOCK1(3), EGFR(4), ELK1(1), ERBB2(3), FARP2(5), FLNA(4), FLNC(5), FLT1(2), FN1(2), GRB2(1), ILK(1), ITGA10(2), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(1), ITGB3(1), ITGB4(2), KDR(6), LAMA1(8), LAMA2(4), LAMA3(4), LAMA4(2), LAMA5(8), LAMB1(2), LAMB2(2), LAMB3(1), LAMB4(2), LAMC1(2), LAMC2(1), MAP2K1(2), MAPK8(1), MET(2), MYLK(3), PAK4(2), PAK6(1), PAK7(2), PARVA(1), PARVB(2), PARVG(1), PDGFC(1), PDGFRB(2), PDPK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PRKCG(2), PTEN(2), PTK2(1), RAF1(4), RAPGEF1(1), RELN(5), RHOA(2), SHC2(1), SOS2(1), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TLN1(3), TLN2(5), TNC(1), TNN(1), TNR(1), TNXB(3), VAV3(1), VEGFB(1), VEGFC(1), VWF(5)	27715924	208	39	201	139	62	49	29	54	14	0	1.000	1.000	1.000
312	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1C(1), AKT2(1), ATF4(3), BDNF(1), BRAF(3), CACNA1A(2), CACNA1C(2), CACNA1E(2), CACNA1F(4), CACNA1G(2), CACNA1H(5), CACNA1S(1), CACNA2D1(3), CACNA2D2(1), CACNA2D3(1), CACNA2D4(3), CACNB4(1), CACNG6(1), CACNG7(1), DUSP16(1), DUSP4(2), DUSP8(1), ECSIT(1), EGFR(4), ELK1(1), FGF12(1), FGF16(1), FGF21(2), FGF5(1), FGF6(1), FGFR2(2), FGFR4(1), FLNA(4), FLNC(5), GRB2(1), IKBKB(2), IL1A(1), IL1R1(1), MAP2K1(2), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAP3K10(1), MAP3K4(1), MAP4K1(1), MAP4K3(2), MAP4K4(1), MAPK11(1), MAPK7(1), MAPK8(1), MAPK8IP1(1), MAPKAPK2(1), MKNK1(1), MOS(1), MYC(6), NF1(2), NFATC2(2), NFATC4(1), NFKB1(1), NFKB2(3), NTRK1(1), PDGFRB(2), PLA2G4A(1), PLA2G5(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCG(2), PTPN7(1), PTPRR(1), RAF1(4), RASA2(2), RPS6KA5(1), RPS6KA6(1), RRAS2(1), SOS2(1), STK3(1), TAOK1(1), TGFB2(1), TNF(3), TRAF6(1)	21918297	136	38	133	91	44	30	18	28	16	0	1.000	1.000	1.000
313	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(3), AXIN2(1), CAMK2G(1), CCND2(1), CCND3(2), CHD8(3), CREBBP(6), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(4), CSNK2B(1), CUL1(1), DAAM2(3), DVL1(1), EP300(3), FZD1(1), FZD10(1), FZD2(1), FZD7(1), LRP5(1), LRP6(1), MAPK8(1), MYC(6), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NKD2(2), PLCB1(5), PLCB3(1), PLCB4(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE2(2), PRKACA(1), PRKCG(2), PSEN1(1), RHOA(2), SKP1(1), SOX17(1), TBL1XR1(2), TCF7L1(1), VANGL1(3), WNT10A(1), WNT16(1), WNT3A(1), WNT5A(1), WNT7B(1), WNT9B(1)	11933323	92	38	92	49	28	11	13	24	16	0	0.979	1.000	1.000
314	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(5), CHAD(1), COL11A1(4), COL1A2(1), COL2A1(1), COL3A1(2), COL4A1(1), COL4A4(2), COL5A1(2), COL5A2(2), COL5A3(1), COL6A1(1), COL6A2(3), COL6A3(2), COL6A6(1), COMP(1), DES(2), DSC1(1), DSC2(1), DSC3(2), DSG1(5), DSG2(1), DSG3(4), DSG4(1), FN1(2), GJA4(1), GJA9(1), GJB4(1), GJD4(1), ITGA6(1), ITGB4(2), KRT1(3), KRT12(2), KRT14(1), KRT16(2), KRT17(1), KRT19(1), KRT20(1), KRT23(1), KRT25(2), KRT3(1), KRT31(1), KRT32(1), KRT33A(1), KRT33B(2), KRT37(2), KRT38(1), KRT6A(1), KRT7(1), KRT72(2), KRT73(3), KRT75(1), KRT78(1), KRT79(1), KRT81(1), KRT82(2), KRT84(2), KRT85(1), KRT86(1), KRT9(1), LAMA1(8), LAMA2(4), LAMA3(4), LAMA4(2), LAMA5(8), LAMB1(2), LAMB2(2), LAMB3(1), LAMB4(2), LAMC1(2), LAMC2(1), RELN(5), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TNC(1), TNN(1), TNR(1), TNXB(3), VWF(5)	18565654	153	37	151	84	49	29	22	40	13	0	0.977	1.000	1.000
315	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(3), ABLIM1(1), ABLIM2(1), ABLIM3(4), ARHGEF12(1), CXCR4(3), DCC(3), EFNB1(1), EPHA1(1), EPHA2(2), EPHA3(4), EPHA5(2), EPHA6(3), EPHA7(2), EPHB1(1), EPHB2(1), EPHB4(2), EPHB6(1), GNAI2(2), L1CAM(1), LIMK1(1), MET(2), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NGEF(1), NTN4(1), PAK4(2), PAK6(1), PAK7(2), PLXNA1(1), PLXNA2(1), PLXNA3(1), PLXNB2(2), PLXNB3(4), PPP3CA(1), PPP3CC(1), PTK2(1), RGS3(1), RHOA(2), ROBO1(2), ROBO2(3), ROBO3(1), SEMA3A(1), SEMA3C(3), SEMA3D(2), SEMA3E(2), SEMA3G(1), SEMA4F(1), SEMA5A(2), SEMA5B(1), SEMA6A(1), SEMA6B(2), SEMA6C(1), SEMA6D(2), SEMA7A(1), SLIT2(2), SLIT3(1), SRGAP1(1), SRGAP2(2), SRGAP3(1), UNC5B(3), UNC5C(3), UNC5D(1)	14737140	110	37	110	92	35	20	14	35	6	0	1.000	1.000	1.000
316	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(3), ADORA1(1), ADORA3(1), ADRA2B(1), ADRA2C(1), ADRB1(1), AGTR1(2), AGTR2(3), AVPR1B(1), CALCRL(2), CHRM3(4), CTSG(1), CYSLTR1(1), EDNRA(1), F2R(1), GABBR2(1), GABRA1(2), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), GABRB1(1), GABRG3(6), GABRQ(3), GALR1(1), GALR2(1), GALR3(1), GH1(1), GH2(1), GHR(1), GHSR(1), GLP2R(1), GLRB(1), GPR156(1), GPR35(1), GPR50(1), GRIA2(3), GRID1(3), GRID2(2), GRIK1(1), GRIK2(1), GRIK4(3), GRIK5(1), GRIN2A(2), GRIN2B(2), GRIN2C(1), GRIN2D(1), GRIN3A(1), GRIN3B(1), GRM1(1), GRM2(1), GRM4(1), GRM5(1), GRM6(1), GRM8(1), HCRTR2(1), HTR1B(1), HTR2A(2), HTR4(1), HTR7(1), LEPR(1), LHB(1), MC1R(1), MCHR1(1), MTNR1A(2), MTNR1B(2), NMUR1(1), NMUR2(1), NPFFR2(1), NPY2R(1), OPRK1(1), OPRM1(1), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(2), P2RY1(1), P2RY10(1), P2RY6(1), PARD3(2), PTAFR(1), PTGFR(1), PTGIR(2), PTH2R(1), RXFP2(3), SCTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(2), TAAR2(1), TACR3(1), THRA(1), THRB(2), TSHR(1), VIPR2(1)	16300709	132	36	132	68	30	26	16	49	11	0	0.956	1.000	1.000
317	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT2(1), CBL(1), CBLB(1), CBLC(2), CCND2(1), CCND3(2), CISH(1), CLCF1(1), CREBBP(6), CSF3R(1), EP300(3), EPOR(1), GH1(1), GH2(1), GHR(1), GRB2(1), IFNA1(1), IFNA10(2), IFNA13(1), IFNA17(1), IFNA4(1), IFNA5(1), IFNAR1(1), IL10RA(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL13RA1(1), IL21R(1), IL22RA2(2), IL2RA(1), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6ST(4), JAK1(2), JAK2(2), JAK3(2), LEPR(1), LIFR(1), MYC(6), OSMR(1), PIAS1(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PIM1(38), PTPN6(4), SOCS1(9), SOCS3(1), SOS2(1), SPRED2(1), SPRY3(1), STAT1(1), STAT2(1), STAT6(4), TPO(4), TYK2(1)	10614516	140	36	132	73	21	42	16	44	14	3	0.943	1.000	1.000
318	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(5), ACTN1(3), ACTN4(1), AKT2(1), AMOTL1(3), ASH1L(1), CGN(2), CLDN22(1), CSNK2A1(4), CSNK2B(1), CTNNA2(2), CTNNA3(3), CTTN(1), EPB41L1(1), EPB41L3(1), EXOC4(3), GNAI2(2), IGSF5(1), INADL(2), LLGL2(3), MAGI1(3), MAGI2(4), MLLT4(1), MPDZ(1), MYH1(3), MYH10(2), MYH11(3), MYH13(2), MYH14(3), MYH2(1), MYH4(1), MYH6(1), MYH7B(1), MYH8(2), MYH9(3), PARD3(2), PARD6G(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PRKCD(1), PRKCG(2), PTEN(2), RHOA(2), RRAS2(1), SPTAN1(1), SYMPK(2), TJP1(2), TJP2(4), TJP3(2), YES1(1)	14176638	102	35	99	72	29	25	13	28	7	0	1.000	1.000	1.000
319	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVRL1(1), AURKB(2), BUB1(1), CDKL1(1), CDKL2(1), CLK2(1), CSNK2A1(4), CSNK2B(1), DGKB(2), DGKD(1), DGKE(1), DGKH(1), DGKQ(1), DGKZ(3), INPP4B(3), ITPKA(1), ITPKB(5), MAP3K10(1), MOS(1), NEK1(3), NEK3(3), OCRL(1), PAK4(2), PIK3C2A(2), PIK3C2G(5), PIK3CA(2), PIK3CG(1), PIM2(1), PLCB1(5), PLCB3(1), PLCB4(1), PLCG2(4), PRKACA(1), PRKCD(1), PRKCG(2), PRKD1(2), PRKG1(2), RAF1(4)	8511200	75	35	75	35	18	13	9	25	10	0	0.902	1.000	1.000
320	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	169	ADCY2(3), ADCY3(1), ADCY4(1), ADCY9(1), ADRA1D(2), ADRB1(1), AGTR1(2), ATP2A3(2), AVPR1B(1), BST1(1), CACNA1A(2), CACNA1C(2), CACNA1E(2), CACNA1F(4), CACNA1G(2), CACNA1H(5), CACNA1S(1), CAMK2G(1), CAMK4(1), CHRM3(4), CYSLTR1(1), EDNRA(1), EGFR(4), ERBB2(3), ERBB4(4), F2R(1), GNAS(1), GRIN2A(2), GRIN2C(1), GRIN2D(1), GRM1(1), GRM5(1), HTR2A(2), HTR4(1), HTR7(1), ITPKA(1), ITPKB(5), ITPR1(3), ITPR2(2), MYLK(3), NOS1(1), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(2), PDE1B(1), PDE1C(3), PDGFRB(2), PHKA1(1), PLCB1(5), PLCB3(1), PLCB4(1), PLCD4(2), PLCE1(2), PLCG2(4), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCG(2), PTAFR(1), PTGFR(1), RYR1(2), RYR2(2), SLC25A6(1), SLC8A1(1), SLC8A3(1), SPHK1(1), SPHK2(1), TACR3(1)	20645101	123	34	121	82	37	21	14	31	19	1	1.000	1.000	1.000
321	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	BMP2(1), BMP7(1), CCL18(1), CCL2(1), CCL27(1), CCR2(2), CCR3(1), CCR6(1), CCR8(2), CD27(1), CLCF1(1), CSF3R(1), CX3CL1(1), CXCL14(1), CXCL3(1), CXCR4(3), CXCR6(1), EDA(1), EGFR(4), EPOR(1), FLT1(2), FLT3(1), FLT3LG(1), GDF5(1), GH1(1), GH2(1), GHR(1), IFNA1(1), IFNA10(2), IFNA13(1), IFNA17(1), IFNA4(1), IFNA5(1), IFNAR1(1), IL10RA(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL13RA1(1), IL17B(1), IL17RA(1), IL1A(1), IL1R1(1), IL21R(1), IL22RA2(2), IL25(1), IL2RA(1), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6ST(4), INHBB(1), INHBE(1), KDR(6), KITLG(1), LEPR(1), LIFR(1), LTA(1), LTB(5), MET(2), NGFR(2), OSMR(1), PDGFC(1), PDGFRB(2), PLEKHO2(2), TGFB2(1), TNF(3), TNFRSF10C(3), TNFRSF11A(1), TNFRSF11B(1), TNFRSF13B(2), TNFRSF18(2), TNFRSF1B(1), TNFRSF21(1), TNFRSF6B(1), TNFRSF8(1), TNFSF13B(1), TNFSF15(1), TNFSF4(1), TPO(4), VEGFB(1), VEGFC(1), XCL1(2)	13030068	124	33	119	80	28	29	18	34	15	0	0.998	1.000	1.000
322	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	DGKB(2), DGKD(1), DGKE(1), DGKH(1), DGKI(5), DGKQ(1), DGKZ(3), IMPA2(1), INPP4B(3), INPP5B(2), ITPKA(1), ITPKB(5), ITPR1(3), ITPR2(2), OCRL(1), PI4KA(1), PIK3C2A(2), PIK3C2G(5), PIK3CA(2), PIK3CD(1), PIK3CG(1), PIP5K1A(1), PIP5K1C(2), PLCB1(5), PLCB3(1), PLCB4(1), PLCD4(2), PLCE1(2), PLCG2(4), PRKCG(2), PTEN(2), SYNJ2(2)	9394739	68	33	68	27	13	11	8	24	12	0	0.655	1.000	1.000
323	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(2), CD36(1), CD44(1), CHAD(1), COL11A1(4), COL1A2(1), COL2A1(1), COL3A1(2), COL4A1(1), COL4A4(2), COL5A1(2), COL5A2(2), COL5A3(1), COL6A1(1), COL6A2(3), COL6A3(2), COL6A6(1), FN1(2), FNDC1(3), FNDC3A(2), FNDC4(1), GP9(1), HMMR(3), HSPG2(4), ITGA10(2), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(1), ITGB3(1), ITGB4(2), LAMA1(8), LAMA2(4), LAMA3(4), LAMA4(2), LAMA5(8), LAMB1(2), LAMB2(2), LAMB3(1), LAMB4(2), LAMC1(2), LAMC2(1), RELN(5), SDC4(2), SPP1(1), SV2B(2), THBS1(1), THBS2(1), THBS4(1), TNC(1), TNN(1), TNR(1), TNXB(3), VWF(5)	16915114	119	33	117	82	40	25	17	27	10	0	0.999	1.000	1.000
324	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	201	ACTN1(3), ACTN4(1), APC(3), ARHGEF1(1), ARHGEF12(1), BCAR1(1), BRAF(3), CHRM3(4), CSK(3), DIAPH3(1), DOCK1(3), EGFR(4), EZR(1), F2R(1), FGF12(1), FGF16(1), FGF21(2), FGF5(1), FGF6(1), FGFR2(2), FGFR4(1), FN1(2), GNA13(2), GSN(1), IQGAP3(1), ITGA10(2), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(1), ITGAD(1), ITGAE(1), ITGB3(1), ITGB4(2), LIMK1(1), MAP2K1(2), MOS(1), MSN(2), MYH10(2), MYH14(3), MYH9(3), MYLK(3), NCKAP1(1), PAK4(2), PAK6(1), PAK7(2), PDGFRB(2), PFN1(3), PIK3CA(2), PIK3CD(1), PIK3CG(1), PIP5K1A(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PTK2(1), RAF1(4), RHOA(2), RRAS2(1), SCIN(1), SOS2(1), SSH1(2), TIAM1(2), TIAM2(5), VAV3(1), WAS(1), WASF1(1), WASL(1)	20793721	122	33	118	105	37	25	16	33	11	0	1.000	1.000	1.000
325	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ATF4(3), BRAF(3), CACNA1C(2), CAMK2G(1), CAMK4(1), CREBBP(6), EP300(3), GRIA2(3), GRIN2A(2), GRIN2B(2), GRIN2C(1), GRIN2D(1), GRM1(1), GRM5(1), ITPR1(3), ITPR2(2), MAP2K1(2), PLCB1(5), PLCB3(1), PLCB4(1), PPP1CA(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCG(2), RAF1(4), RAPGEF3(3), RPS6KA6(1)	7533361	59	30	59	29	12	8	10	18	11	0	0.917	1.000	1.000
326	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1C(1), ACVRL1(1), BMP2(1), BMP5(1), BMP7(1), CDKN2B(1), CHRD(3), COMP(1), CREBBP(6), CUL1(1), EP300(3), GDF5(1), ID3(2), INHBB(1), INHBE(1), LEFTY1(2), LTBP1(3), MYC(6), PITX2(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), RHOA(2), SKP1(1), SMAD7(1), SMAD9(1), SMURF1(1), SMURF2(1), TGFB2(1), THBS1(1), THBS2(1), THBS4(1), TNF(3)	7290751	56	29	55	32	14	14	7	13	8	0	0.955	1.000	1.000
327	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	126	CADM1(1), CADM3(1), CD22(1), CD274(1), CD276(1), CD58(1), CD8B(1), CDH1(1), CDH15(1), CDH2(2), CDH3(1), CDH4(2), CLDN22(1), CNTN1(2), CNTN2(1), CNTNAP1(2), HLA-DMA(1), HLA-DMB(1), HLA-DPA1(2), HLA-DQB1(1), HLA-DRB5(4), HLA-G(1), ICOSLG(1), ITGA4(2), ITGA6(1), L1CAM(1), MPZL1(1), NCAM2(4), NEGR1(2), NFASC(1), NLGN1(1), NRCAM(1), NRXN1(2), NRXN2(1), NRXN3(2), PTPRC(1), PTPRF(1), PTPRM(1), PVR(2), PVRL1(3), PVRL2(1), SDC4(2), SIGLEC1(1), VCAM1(1), VCAN(8)	10725402	71	29	71	48	21	12	12	17	8	1	0.989	1.000	1.000
328	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTB(5), ACTN1(3), ACTN4(1), ACVR1C(1), CDH1(1), CREBBP(6), CSNK2A1(4), CSNK2B(1), CTNNA2(2), CTNNA3(3), CTNND1(1), EGFR(4), EP300(3), ERBB2(3), FARP2(5), FER(1), INSR(1), LMO7(4), MET(2), MLLT4(1), PARD3(2), PTPN1(1), PTPN6(4), PTPRF(1), PTPRJ(2), PTPRM(1), PVRL1(3), PVRL2(1), RHOA(2), SNAI1(1), SSX2IP(1), TCF7L1(1), TJP1(2), WAS(1), WASF1(1), WASF3(2), WASL(1), YES1(1)	8784691	80	29	76	44	21	13	12	25	9	0	0.976	1.000	1.000
329	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY2(3), ADCY3(1), ADCY4(1), ADCY6(1), ADCY9(1), CAMK2G(1), CREB3L4(1), CREBBP(6), DCT(1), DVL1(1), EP300(3), FZD1(1), FZD10(1), FZD2(1), FZD7(1), GNAI2(2), GNAS(1), KITLG(1), MAP2K1(2), MC1R(1), MITF(1), PLCB1(5), PLCB3(1), PLCB4(1), POMC(1), PRKACA(1), PRKCG(2), RAF1(4), TCF7L1(1), TYR(2), TYRP1(1), WNT10A(1), WNT16(1), WNT3A(1), WNT5A(1), WNT7B(1), WNT9B(1)	8098212	57	29	57	42	14	10	10	16	7	0	0.999	1.000	1.000
330	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(5), BCL2(1), CABIN1(3), CAMK4(1), CD3G(1), CDKN1A(2), CREBBP(6), CSNK2A1(4), CSNK2B(1), EP300(3), FCGR3A(1), GATA3(2), IFNA1(1), IL2RA(1), IL6(2), JUNB(1), MAPK8(1), MEF2B(3), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB2(3), NFKBIB(1), NUP214(1), P2RX7(2), PPP3CC(1), PTPRC(1), SFN(2), SLA(1), TNF(3), VAV3(1)	6702073	61	28	60	27	15	12	7	17	10	0	0.723	1.000	1.000
331	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	130	ACACA(1), ACACB(6), AKT2(1), BRAF(3), CBL(1), CBLB(1), CBLC(2), ELK1(1), EXOC7(2), FASN(1), FBP2(2), FOXO1(2), GRB2(1), IKBKB(2), INSR(1), IRS4(1), LIPE(2), MAP2K1(2), MAPK8(1), MKNK1(1), PCK2(1), PDE3A(6), PDPK1(1), PHKA1(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PPP1CA(1), PPP1R3A(4), PRKAA1(1), PRKACA(1), PTPN1(1), PTPRF(1), PYGB(1), PYGL(1), RAF1(4), RAPGEF1(1), SHC2(1), SLC2A4(1), SOCS1(9), SOCS3(1), SOS2(1), SREBF1(1), TRIP10(1)	12048196	78	28	77	62	20	24	12	13	9	0	1.000	1.000	1.000
332	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY2(3), ADCY3(1), ADCY4(1), ADCY6(1), ADCY9(1), ADRA1D(2), ADRB1(1), ATP2A3(2), CACNA1A(2), CACNA1C(2), CACNA1E(2), CACNA1S(1), CAMK2G(1), CAMK4(1), CASQ1(1), CHRM3(4), GJA4(1), GJB4(1), GNAI2(2), GNGT1(1), ITPR1(3), ITPR2(2), KCNJ3(1), PLCB3(1), PRKACA(1), PRKCD(1), PRKCG(2), PRKD1(2), RGS1(1), RGS14(2), RGS3(1), RGS6(1), RGS7(1), RGS9(1), RYR1(2), RYR2(2), SFN(2), SLC8A1(1), SLC8A3(1)	14188441	59	27	59	57	10	17	5	15	11	1	1.000	1.000	1.000
333	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	164	ADORA1(1), ADORA3(1), ADRA1D(2), ADRA2C(1), ADRB1(1), AGTR1(2), AGTR2(3), AVPR1B(1), CCR2(2), CCR3(1), CCR6(1), CCR8(2), CHML(1), CHRM3(4), CXCR4(3), EDNRA(1), F2R(1), GALR1(1), GALR2(1), GALR3(1), GHSR(1), GPR35(1), GPR50(1), GPR87(1), HCRTR2(1), HTR1B(1), HTR2A(2), HTR4(1), HTR7(1), MC1R(1), MTNR1A(2), MTNR1B(2), NMUR1(1), NMUR2(1), NPY2R(1), OPRK1(1), OPRM1(1), OR10A5(1), OR11A1(2), OR12D3(1), OR1F1(1), OR2H1(4), OR7C1(1), P2RY1(1), P2RY10(1), P2RY6(1), PTAFR(1), PTGFR(1), PTGIR(2), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(2)	8860857	73	27	71	37	11	16	9	30	7	0	0.911	1.000	1.000
334	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	83	AGL(1), AMY2A(1), AMY2B(2), ASCC3(1), DDX23(1), DDX41(1), DDX47(2), DDX51(2), DDX52(2), DDX54(2), DDX55(2), ENTPD7(1), EP400(1), ERCC2(1), GAA(1), GANC(1), GBA(2), GBE1(1), HK2(1), HK3(1), IFIH1(2), MGAM(7), NUDT5(1), PGM3(1), PYGB(1), PYGL(1), RAD54B(2), SETX(1), SI(2), SKIV2L2(1), SMARCA2(2), SMARCA5(1), UGT1A10(1), UGT2B11(1), UGT2B17(2), UGT2B7(2), UXS1(1)	9719884	56	27	56	33	14	7	12	13	10	0	0.992	1.000	1.000
335	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(3), ACTN1(3), AKT2(1), ANGPTL2(1), BCAR1(1), BRAF(3), CAV1(1), CDKN2A(1), DOCK1(3), EPHB2(1), GRB2(1), ILK(1), ITGA10(2), ITGA11(4), ITGA2(1), ITGA4(2), ITGA5(1), ITGA6(1), MAP2K4(1), MAP3K11(1), MAPK8(1), MAPK8IP1(1), MYLK(3), PAK4(2), PAK6(1), PAK7(2), PIK3CA(2), PLCG2(4), PTEN(2), PTK2(1), RAF1(4), SOS2(1), TLN1(3), TLN2(5), WAS(1)	9117849	66	27	64	47	22	17	9	14	4	0	0.997	1.000	1.000
336	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(3), AKT2(1), BRAF(3), CAMK2G(1), CBL(1), CBLB(1), CBLC(2), CDKN1A(2), EGFR(4), ELK1(1), ERBB2(3), ERBB4(4), GAB1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAPK8(1), MYC(6), NRG1(2), NRG2(1), PAK4(2), PAK6(1), PAK7(2), PIK3CA(2), PIK3CD(1), PIK3CG(1), PLCG2(4), PRKCG(2), PTK2(1), RAF1(4), SHC2(1), SOS2(1)	7651688	63	26	60	52	15	17	11	15	5	0	1.000	1.000	1.000
337	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(3), ATM(8), ATR(2), BUB1(1), BUB1B(1), CCNB2(1), CCNB3(1), CCND2(1), CCND3(2), CDC14A(1), CDC16(2), CDC25C(2), CDC27(2), CDKN1A(2), CDKN2A(1), CDKN2B(1), CHEK2(2), CREBBP(6), CUL1(1), DBF4(2), E2F1(2), E2F2(1), E2F3(1), EP300(3), ESPL1(1), FZR1(1), HDAC2(2), MAD2L1(1), MCM4(1), PKMYT1(2), PLK1(1), RB1(1), SFN(2), SKP1(1), SKP2(1), SMC1B(2), TGFB2(1)	10049031	66	26	64	37	13	11	17	16	8	1	0.977	1.000	1.000
338	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT2(1), BCL10(1), CBL(1), CBLB(1), CBLC(2), CD247(1), CD3D(1), CD3G(1), CD8B(1), GRAP2(1), GRB2(1), IKBKB(2), LCP2(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(1), NFKB2(3), NFKBIA(3), NFKBIB(1), PAK4(2), PAK6(1), PAK7(2), PIK3CA(2), PIK3CD(1), PIK3CG(1), PPP3CA(1), PPP3CC(1), PTPN6(4), PTPRC(1), RHOA(2), SOS2(1), TNF(3), VAV3(1), ZAP70(1)	7285366	53	26	53	21	19	11	6	9	8	0	0.392	1.000	1.000
339	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	BRAF(3), CACNA1A(2), GNA13(2), GNAI2(2), GNAS(1), GRIA2(3), GRID2(2), GRM1(1), GRM5(1), GUCY1A3(1), ITPR1(3), ITPR2(2), LYN(2), MAP2K1(2), NOS1(1), NPR1(1), NPR2(1), PLA2G4A(1), PLA2G5(1), PLCB1(5), PLCB3(1), PLCB4(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PRKCG(2), PRKG1(2), PRKG2(1), RAF1(4), RYR1(2)	8265697	55	26	54	30	14	11	9	11	10	0	0.950	1.000	1.000
340	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY2(3), ADCY3(1), ADCY4(1), ADCY6(1), ADCY9(1), ATF4(3), CACNA1C(2), CACNA1F(4), CACNA1S(1), CAMK2G(1), EGFR(4), ELK1(1), GNAS(1), GNRH1(1), GRB2(1), ITPR1(3), ITPR2(2), LHB(1), MAP2K1(2), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAP3K4(1), MAPK11(1), MAPK7(1), MAPK8(1), MMP2(1), PLA2G4A(1), PLA2G5(1), PLCB1(5), PLCB3(1), PLCB4(1), PLD1(1), PLD2(2), PRKACA(1), PRKCD(1), RAF1(4), SOS2(1)	9645542	64	26	62	37	14	16	10	14	10	0	0.922	1.000	1.000
341	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY2(3), ADCY3(1), ADCY4(1), ADCY6(1), ADCY9(1), AKAP1(1), AKAP10(1), AKAP11(3), AKAP3(1), AKAP4(2), AKAP5(1), AKAP7(1), AKAP9(3), ARHGEF1(1), GNA13(2), GNAI2(2), GNGT1(1), IL18BP(1), ITPR1(3), KCNJ3(1), PALM2(1), PDE1B(1), PDE1C(3), PDE4A(2), PDE4C(2), PLCB3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCD(1), PRKCG(2), PRKD1(2), RHOA(2)	8544817	51	25	51	39	12	14	6	13	6	0	0.997	1.000	1.000
342	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(1), ABCA10(1), ABCA12(1), ABCA13(5), ABCA2(1), ABCA3(4), ABCA4(1), ABCA7(5), ABCA8(3), ABCB1(2), ABCB5(4), ABCB8(3), ABCB9(1), ABCC1(2), ABCC10(2), ABCC11(1), ABCC12(3), ABCC2(1), ABCC3(2), ABCC6(5), ABCD4(2), ABCG4(2), ABCG8(1), CFTR(2), TAP1(1)	8858326	56	25	55	39	13	6	7	17	13	0	0.999	1.000	1.000
343	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ATP6V0A1(2), ATP6V0A4(1), ATP6V0D2(1), ATP6V1G3(1), CSK(3), EGFR(4), IGSF5(1), IKBKB(2), LYN(2), MAP2K4(1), MAPK11(1), MAPK8(1), MET(2), NFKB1(1), NFKB2(3), NFKBIA(3), NOD1(1), PLCG2(4), PTPRZ1(4), TJP1(2)	5259254	40	25	38	34	13	4	8	11	4	0	1.000	1.000	1.000
344	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(3), ELK1(1), GRB2(1), IKBKB(2), MAP2K1(2), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K4(1), MAP4K1(1), MAP4K3(2), MAP4K4(1), MAP4K5(1), MAPK11(1), MAPK7(1), MAPK8(1), MAPKAPK2(1), MEF2B(3), MKNK1(1), MYC(6), NFKB1(1), NFKBIA(3), RAF1(4), RPS6KA5(1), STAT1(1), TGFB2(1)	7345625	48	25	46	37	7	11	11	13	6	0	0.999	1.000	1.000
345	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY2(3), ADCY3(1), ADCY4(1), ADCY6(1), ADCY9(1), ATF4(3), ATP2A3(2), CALCA(1), CAMK2G(1), DGKZ(3), ETS2(2), GNGT1(1), GUCY1A3(1), IGFBP4(1), IL6(2), ITPR1(3), ITPR2(2), NFKB1(1), NOS1(1), PLCB3(1), PLCG2(4), PRKACA(1), PRKCD(1), PRKD1(2), RGS1(1), RGS14(2), RGS3(1), RGS6(1), RGS7(1), RGS9(1), RYR1(2), RYR2(2), SFN(2), SLC8A1(1), TNXB(3)	13051165	57	25	57	57	11	15	8	15	7	1	1.000	1.000	1.000
346	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BFAR(1), BTK(2), CAD(1), CASP8(2), CSNK1A1(2), DFFA(1), EGFR(4), EPHB2(1), FAF1(1), IL1A(1), MAP2K4(1), MAP3K1(3), MAPK8(1), MAPK8IP1(1), MET(2), NFKB1(1), NFKB2(3), NFKBIA(3), NFKBIB(1), PFN1(3), PTPN13(1), RALBP1(1), TNFRSF6B(1), TPX2(1), TUFM(1)	5411995	40	25	38	41	11	6	9	9	5	0	1.000	1.000	1.000
347	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG1(3), ALG10(1), ALG11(1), ALG12(1), ALG14(2), ALG6(3), ALG9(1), B3GNT1(1), B3GNT6(1), B4GALT3(1), CHST11(1), CHST12(2), CHST2(1), CHST4(2), CHST6(1), EXT1(1), EXT2(1), EXTL3(1), FUT8(1), GALNT1(1), GALNT10(1), GALNT2(1), GALNT4(1), GALNT8(2), GANAB(2), GCNT1(2), HS3ST1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(2), HS6ST2(1), HS6ST3(1), MAN1A2(1), MAN1B1(1), MAN1C1(1), MGAT1(2), MGAT4A(2), MGAT5(1), MGAT5B(1), NDST1(1), NDST3(1), ST6GAL1(3), UST(1), WBSCR17(1), XYLT1(2), XYLT2(1)	8188685	62	24	60	28	10	16	9	23	4	0	0.779	1.000	1.000
348	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY2(3), ADCY3(1), ADCY4(1), ADCY6(1), ADCY9(1), ADRB1(1), EGFR(4), GNAI2(2), GNAS(1), GRB2(1), GRM1(1), GRM5(1), GUCY1A3(1), HTR2A(2), ITPR1(3), ITPR2(2), MAP2K1(2), MAPK7(1), NPR1(1), NPR2(1), PDGFC(1), PDGFRB(2), PLCB1(5), PLCB3(1), PLCB4(1), PRKACA(1), PRKCG(2), PRKG1(2), PRKG2(1), RAF1(4), SOS2(1), TJP1(2), TUBA3D(1), TUBA8(2), TUBB1(1)	9829344	58	24	57	41	12	15	8	15	8	0	0.998	1.000	1.000
349	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(3), ACTN4(1), BCAR1(1), CLDN22(1), CTNNA2(2), CTNNA3(3), CTNND1(1), CXCR4(3), CYBB(1), EZR(1), GNAI2(2), ITGA4(2), MAPK11(1), MLLT4(1), MMP2(1), MSN(2), PIK3CA(2), PIK3CD(1), PIK3CG(1), PLCG2(4), PRKCG(2), PTK2(1), RAPGEF3(3), RHOA(2), SIPA1(1), VAV3(1), VCAM1(1)	9309365	45	24	43	23	15	7	6	12	5	0	0.881	1.000	1.000
350	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	BCAR1(1), CAPN2(1), CAPN9(1), CAV1(1), CSK(3), DOCK1(3), GRB2(1), ILK(1), ITGA10(2), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(1), ITGAD(1), ITGAE(1), ITGB3(1), ITGB4(2), MAP2K1(2), MAP2K3(2), MAPK7(1), PAK4(2), PAK6(1), PDPK1(1), PTK2(1), RAPGEF1(1), TLN1(3), TNS1(4), VAV3(1)	10157057	48	24	48	53	17	10	5	11	5	0	1.000	1.000	1.000
351	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	ELK1(1), GNGT1(1), MAP2K1(2), MAP2K3(2), MAP3K1(3), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(1), NFKBIA(3), PIK3C2G(5), PLCB1(5), PPP3CA(1), PPP3CC(1), RAF1(4)	2892818	35	23	34	14	7	4	8	10	6	0	0.655	1.000	1.000
352	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(1), ALG6(3), CCR2(2), CCR3(1), CELSR1(4), CELSR2(1), CELSR3(1), CHRM3(4), CIDEB(1), EDNRA(1), EMR2(1), EMR3(1), F2R(1), GPR116(1), GPR133(3), GPR55(2), GPR56(1), GRM1(1), LPHN2(3), LPHN3(1), PTGFR(1), SMO(1), SSTR2(1), TSHR(1), VN1R1(1)	4908410	39	23	39	18	9	6	4	19	1	0	0.825	1.000	1.000
353	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY2(3), ADCY3(1), ADCY4(1), ADCY6(1), ADCY9(1), ADSSL1(1), AK2(2), ALLC(1), AMPD1(1), AMPD3(1), DCK(1), ENTPD3(1), ENTPD4(1), ENTPD5(2), GDA(1), GMPS(1), GUCY1A3(1), NPR1(1), NPR2(1), NT5C(1), NT5C1B(1), NT5M(1), NUDT5(1), NUDT9(1), PAPSS1(1), PDE10A(1), PDE11A(1), PDE1C(3), PDE4A(2), PDE4C(2), PDE5A(2), PDE6H(1), PDE9A(2), PFAS(2), POLD3(1), POLE(2), POLR1A(3), POLR1B(1), POLR2B(1), POLR2E(1), POLR3A(2), PRUNE(1), RFC5(1), RRM1(1)	12165105	59	23	59	29	19	7	11	18	4	0	0.869	1.000	1.000
354	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA2(1), INPP4B(3), INPP5B(2), ITPKA(1), ITPKB(5), OCRL(1), PI4KA(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PIP5K1A(1), PIP5K1C(2), PLCB1(5), PLCB3(1), PLCB4(1), PLCD4(2), PLCE1(2), PLCG2(4), PTEN(2), SYNJ2(2)	5547705	40	23	40	17	8	8	4	11	9	0	0.671	1.000	1.000
355	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AKT2(1), ATM(8), BCL2(1), BIRC2(1), CAPN2(1), CASP8(2), DFFA(1), ENDOG(2), IKBKB(2), IL1A(1), IL1R1(1), IL3RA(1), IRAK2(1), NFKB1(1), NFKB2(3), NFKBIA(3), NTRK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PPP3CA(1), PPP3CC(1), PRKACA(1), TNF(3), TNFRSF10C(3)	6102272	44	23	41	29	12	9	9	8	6	0	0.968	1.000	1.000
356	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT2(1), CASP8(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA17(1), IFNA4(1), IFNA5(1), IFNAR1(1), IKBKB(2), IKBKE(1), IL12B(2), IL6(2), IRF5(1), LBP(1), MAP2K1(2), MAP2K3(2), MAP2K4(1), MAPK11(1), MAPK8(1), NFKB1(1), NFKB2(3), NFKBIA(3), PIK3CA(2), PIK3CD(1), PIK3CG(1), SPP1(1), STAT1(1), TIRAP(1), TLR2(2), TLR3(1), TLR4(2), TLR6(1), TNF(3), TRAF6(1)	6592106	51	23	50	30	17	7	9	12	6	0	0.930	1.000	1.000
357	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(3), APOA1(1), CD36(1), CREBBP(6), EHHADH(2), EP300(3), HSD17B4(1), MYC(6), NCOA1(1), NCOR1(1), NCOR2(4), NFKBIA(3), NRIP1(1), PIK3CA(2), PTGS2(1), RB1(1), TNF(3)	4739156	40	23	40	22	6	4	10	14	6	0	0.932	1.000	1.000
358	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT2(1), BRAF(3), EGFR(4), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(5), ITPR1(3), ITPR2(2), KCNJ3(1), PITX2(1), PLCB1(5), PLCB3(1), PLCB4(1), RAF1(4), SOS2(1)	4200931	35	23	34	21	6	10	4	7	8	0	0.925	1.000	1.000
359	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	BRAF(3), CD247(1), CD48(1), FCGR3A(1), GRB2(1), HLA-G(1), IFNA1(1), IFNA10(2), IFNA13(1), IFNA17(1), IFNA4(1), IFNA5(1), IFNAR1(1), KIR3DL1(1), KIR3DL2(1), KLRK1(1), LCP2(1), MAP2K1(2), MICA(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PRF1(2), PRKCG(2), PTPN6(4), RAF1(4), SHC2(1), SOS2(1), TNF(3), TNFRSF10C(3), ULBP3(1), VAV3(1), ZAP70(1)	8145431	62	22	61	40	17	13	12	12	8	0	0.984	1.000	1.000
360	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(6), ACSL3(2), ACSL5(1), ADIPOQ(2), AKT2(1), CD36(1), CPT1C(1), CPT2(1), IKBKB(2), IRS4(1), JAK1(2), JAK2(2), JAK3(2), LEPR(1), MAPK8(1), NFKB1(1), NFKB2(3), NFKBIA(3), NFKBIB(1), PCK2(1), POMC(1), PRKAA1(1), SLC2A4(1), SOCS3(1), TNF(3), TNFRSF1B(1), TYK2(1)	6035220	44	22	43	34	16	10	6	8	4	0	0.996	1.000	1.000
361	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT2(1), BCR(1), BTK(2), CSK(3), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(5), LYN(2), MAP2K1(2), NFKB1(1), NFKB2(3), NFKBIA(3), NFKBIB(1), PIK3CA(2), PIK3CD(1), PLCG2(4), RAF1(4), SOS2(1)	3861506	39	22	38	17	10	8	7	7	7	0	0.621	1.000	1.000
362	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	81	ABL1(3), ATM(8), BUB1(1), BUB1B(1), CCNB2(1), CCNB3(1), CCND2(1), CCND3(2), CDAN1(3), CDC14A(1), CDC25C(2), CDH1(1), CDKN1A(2), CDKN2A(1), CHEK2(2), E2F1(2), E2F2(1), E2F3(1), EP300(3), ESPL1(1), HDAC2(2), HDAC8(1), MAD2L1(1), MCM4(1), MPEG1(5), PLK1(1), PTPRA(1), RB1(1), SKP2(1)	8149628	52	21	50	43	11	14	12	7	7	1	1.000	1.000	1.000
363	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(3), EGFR(4), ERBB2(3), ERBB4(4), ETS1(1), ETS2(2), ETV6(1), ETV7(2), FMN2(3), GRB2(1), MAP2K1(2), NOTCH1(1), NOTCH2(4), NOTCH3(1), NOTCH4(1), PIWIL1(2), RAF1(4), SOS2(1), SPIRE2(1)	3884971	41	21	39	29	8	9	6	10	7	1	0.996	1.000	1.000
364	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	69	A2M(1), C1S(3), C3(3), C4A(2), C4BPA(1), C5(2), C6(3), C7(1), C8A(1), C8B(1), CFH(2), CFI(2), CR1(1), CR2(1), F10(1), F11(1), F12(1), F13B(1), F2R(1), F5(1), F7(1), F8(1), FGG(1), KLKB1(1), MASP2(2), MBL2(1), PLAT(1), PLG(1), PROC(1), SERPINA5(1), SERPIND1(2), VWF(5)	7751213	48	21	48	27	15	13	3	14	3	0	0.945	1.000	1.000
365	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	CD1B(1), CD1E(1), CD22(1), CD33(3), CD36(1), CD3D(1), CD3G(1), CD44(1), CD8B(1), CR1(1), CR2(1), CSF3R(1), EPOR(1), FCER2(1), FLT3(1), FLT3LG(1), GP9(1), HLA-DRB5(4), IL1A(1), IL1R1(1), IL2RA(1), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), ITGA2(1), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(1), ITGB3(1), KITLG(1), MME(2), TNF(3), TPO(4)	6127055	48	21	48	44	10	12	10	9	7	0	1.000	1.000	1.000
366	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4B(3), ITPKA(1), ITPKB(5), OCRL(1), PIK3C2A(2), PIK3C2G(5), PIK3CA(2), PIK3CG(1), PLCB1(5), PLCB3(1), PLCB4(1), PLCG2(4)	3347357	31	21	31	11	3	5	2	14	7	0	0.665	1.000	1.000
367	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), EGFR(4), ETS1(1), ETS2(2), HOXA7(1), IKBKB(2), MAP2K1(2), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAPK8(1), NFKB1(1), NFKBIA(3), PPP2CA(1), PRKCD(1), PRKCG(2), RAF1(4), TNF(3), TNFRSF1B(1)	3488884	36	21	34	24	7	11	9	5	4	0	0.969	1.000	1.000
368	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN4(1), DES(2), DMD(2), MYBPC2(1), MYBPC3(1), MYH6(1), MYH8(2), MYOM1(2), NEB(3), TMOD1(1), TPM1(1), TTN(23)	10289363	40	21	40	25	15	8	7	7	3	0	0.977	1.000	1.000
369	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	BCL2(1), BIRC2(1), CASP1(1), CASP4(2), CASP8(2), DFFA(1), IKBKB(2), IRF1(3), IRF2(1), IRF5(1), LTA(1), MAP2K4(1), MAP3K1(3), MYC(6), NFKB1(1), NFKBIA(3), NFKBIB(1), PRF1(2), TNF(3), TNFRSF1B(1), TNFRSF21(1)	4091673	38	20	37	31	11	4	7	10	6	0	0.998	1.000	1.000
370	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(6), DTX1(4), DTX2(1), DTX3L(2), DVL1(1), EP300(3), HDAC2(2), JAG1(1), MAML1(1), MAML2(2), MAML3(5), NCOR2(4), NOTCH1(1), NOTCH2(4), NOTCH3(1), NOTCH4(1), NUMBL(1), PSEN1(1), PTCRA(2), RBPJL(5)	5412659	48	20	48	32	7	6	9	18	8	0	0.997	1.000	1.000
371	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT2(1), KDR(6), MAP2K1(2), MAPK11(1), MAPKAPK2(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PLA2G4A(1), PLA2G5(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PRKCG(2), PTGS2(1), PTK2(1), RAF1(4), SHC2(1), SPHK1(1), SPHK2(1)	5390444	40	20	38	18	14	5	9	10	2	0	0.704	1.000	1.000
372	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT2(1), BTK(2), GRB2(1), LCP2(1), LYN(2), MAP2K1(2), MAP2K3(2), MAP2K4(1), MAPK11(1), MAPK8(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PLA2G4A(1), PLA2G5(1), PLCG2(4), PRKCD(1), RAF1(4), SOS2(1), TNF(3), VAV3(1)	5223246	34	20	33	20	8	8	9	4	5	0	0.904	1.000	1.000
373	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY2(3), ADCY3(1), ADCY4(1), ADCY6(1), AK2(2), ALLC(1), AMPD1(1), AMPD3(1), DCK(1), GDA(1), GMPS(1), GUCY1A3(1), NPR1(1), NPR2(1), NT5C(1), NT5M(1), PAPSS1(1), PDE4A(2), PDE4C(2), PDE5A(2), PDE9A(2), PFAS(2), POLE(2), POLG(1), POLQ(6), POLR1B(1), POLR2B(1), POLR2E(1), POLRMT(3), PRUNE(1), RRM1(1)	9553111	47	20	47	24	11	11	7	15	3	0	0.806	1.000	1.000
374	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT2(1), CDKN2A(1), ERBB4(4), GAB1(1), GRB2(1), IRS4(1), MET(2), MYC(6), PAK4(2), PAK6(1), PAK7(2), PARD3(2), PIK3CA(2), PIK3CD(1), PREX1(1), PTEN(2), PTK2(1), PTPN1(1), SFN(2), SLC2A4(1), SOS2(1)	5630802	36	20	36	43	7	9	4	12	4	0	1.000	1.000	1.000
375	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	BRAF(3), CREBBP(6), EGR1(1), EGR4(1), ELK1(1), MAP1B(3), MAP2K4(1), MAPK8(1), MAPK8IP1(1), NTRK1(1), OPN1LW(1), PIK3C2G(5), PIK3CA(2), PIK3CD(1)	3905858	28	20	28	25	5	5	5	11	2	0	0.998	1.000	1.000
376	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(3), CCND2(1), CCND3(2), CSNK1E(1), DVL1(1), FZD1(1), FZD10(1), FZD2(1), FZD7(1), MYC(6), PRKCD(1), PRKCG(2), PRKD1(2), RHOA(2), WNT10A(1), WNT16(1), WNT5A(1), WNT7B(1)	4287548	29	20	29	28	8	5	4	9	3	0	1.000	1.000	1.000
377	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(8), CCND2(1), CCND3(2), CCNG2(1), CDKN1A(2), CDKN2A(1), CDKN2B(1), CREB3L4(1), E2F1(2), E2F2(1), E2F3(1), MCM4(1), MYC(6), MYT1(1), POLE(2), RB1(1), TFDP2(1), TNXB(3)	5678492	36	19	34	29	4	9	9	10	4	0	0.997	1.000	1.000
378	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(1), BMP5(1), BMP7(1), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK1G3(1), GLI2(2), GLI3(1), LRP2(7), PRKACA(1), PTCH1(1), PTCH2(1), SHH(1), SMO(1), STK36(1), WNT10A(1), WNT16(1), WNT3A(1), WNT5A(1), WNT7B(1), WNT9B(1)	4469825	31	19	31	26	10	3	5	9	4	0	1.000	1.000	1.000
379	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	AGT(1), CAMK4(1), CREBBP(6), CSNK1A1(2), MAP2K1(2), MAPK8(1), MYH2(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NKX2-5(1), PIK3CA(2), PPP3CA(1), PPP3CC(1), RAF1(4)	3721089	29	19	29	19	7	5	6	7	4	0	0.963	1.000	1.000
380	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AGTR2(3), ATP8A1(2), AVPR1B(1), CCR2(2), CCR3(1), CCR6(1), CCR8(2), CXCR4(3), CXCR6(1), EDNRA(1), GALR1(1), GALR2(1), GALR3(1), GHSR(1), MC1R(1), NPY2R(1), OPRK1(1), OPRM1(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(2), TACR3(1), TSHR(1)	3777692	34	19	33	14	4	10	2	14	4	0	0.500	1.000	1.000
381	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(1), BCL2(1), BCR(1), BTK(2), CD22(1), CR2(1), CSK(3), GRB2(1), ITPR1(3), ITPR2(2), LYN(2), MAP4K1(1), NFATC1(2), NFATC2(2), PIK3CA(2), PIK3CD(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PTPRC(1), RAF1(4), SOS2(1)	5419191	38	19	37	16	9	6	8	7	8	0	0.504	1.000	1.000
382	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(3), AR(4), BRAF(3), EGFR(4), ITPKA(1), ITPKB(5), ITPR1(3), ITPR2(2), KCNJ3(1), PIK3CA(2), PIK3CD(1), PITX2(1), PTX3(1), RAF1(4)	3963767	35	19	34	27	5	11	5	9	5	0	0.995	1.000	1.000
383	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT2(1), ITPKA(1), ITPKB(5), ITPR1(3), ITPR2(2), NFKB1(1), NFKB2(3), NFKBIA(3), NFKBIB(1), PITX2(1), PLD1(1), PLD2(2), VN1R1(1)	3377999	25	19	25	12	7	3	3	6	6	0	0.647	1.000	1.000
384	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(3), CREBBP(6), CSNK1A1(2), CSNK2A1(4), DVL1(1), FZD1(1), MYC(6), PPP2CA(1)	2234633	24	19	24	16	2	5	3	9	5	0	0.974	1.000	1.000
385	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	BCL2(1), BCL2A1(2), BOK(1), CASP1(1), CASP4(2), CASP8(2), DFFA(1), IKBKE(1), LTA(1), MCL1(1), NFKB1(1), NFKBIA(3), NGFR(2), NTRK1(1), PTPN13(1), TFG(1), TNF(3), TNFRSF1B(1), TRAF6(1)	3174219	27	18	27	22	10	3	3	6	5	0	0.992	1.000	1.000
386	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(4), ELK1(1), GNAS(1), GNGT1(1), GRB2(1), MAP2K1(2), MKNK1(1), MYC(6), NGFR(2), PPP2CA(1), PTPRR(1), RAF1(4), RPS6KA5(1)	2359550	26	18	25	23	6	9	4	5	2	0	0.996	1.000	1.000
387	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(1), AGPAT2(1), CHAT(2), CHKA(1), DGKB(2), DGKD(1), DGKE(1), DGKH(1), DGKI(5), DGKQ(1), DGKZ(3), ETNK2(1), GPAM(1), GPD1(1), GPD1L(1), GPD2(2), LYPLA1(1), PCYT1B(1), PEMT(1), PLA2G4A(1), PLA2G5(1), PLD1(1), PLD2(2)	4960637	33	18	33	17	9	5	6	11	2	0	0.866	1.000	1.000
388	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(3), CDR1(1), DGKI(5), IL6ST(4), MRPL19(2), RPL13(1), RPL3(1), RPL37(1), RPL3L(2), RPL4(1), RPL6(1), RPS6KA6(1), TBC1D10C(1), UBB(1)	3795127	25	18	25	14	6	7	2	7	3	0	0.920	1.000	1.000
389	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT2(1), ANGPTL2(1), ARHGEF11(2), BTK(2), GDI1(1), ITPR1(3), ITPR2(2), LIMK1(1), MYLK(3), PAK4(2), PAK6(1), PAK7(2), PIK3CA(2), PIK3CD(1), PIK3CG(1), PITX2(1), PTEN(2), RACGAP1(1), WASF1(1), WASL(1)	5210714	31	18	31	14	13	3	7	4	4	0	0.640	1.000	1.000
390	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(1), ASH2L(1), EHMT1(1), EHMT2(1), EZH2(6), KDM6A(1), NSD1(3), PPP1CA(1), PRDM2(1), PRDM9(4), PRMT8(1), SETD1A(1), SETMAR(2), SMYD3(1), SUV39H1(1), SUV39H2(1), SUV420H2(1), WHSC1(2), WHSC1L1(1)	9124090	31	17	29	15	6	5	4	16	0	0	0.884	1.000	1.000
391	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(3), ATM(8), BRCA1(2), CDKN1A(2), CHEK2(2), MAPK8(1), NFKB1(1), NFKBIA(3), RAD50(1)	2095257	23	17	21	14	4	6	9	2	1	1	0.912	1.000	1.000
392	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	ATM(8), ATR(2), CASP8(2), CCNB2(1), CCNB3(1), CCND2(1), CCND3(2), CCNG2(1), CDKN1A(2), CDKN2A(1), CHEK2(2), PTEN(2), SFN(2), THBS1(1)	4756879	28	17	26	16	3	7	9	6	2	1	0.869	1.000	1.000
393	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2(1), CBL(1), E2F1(2), GRB2(1), IL2RA(1), JAK1(2), JAK3(2), MYC(6), PIK3CA(2), PTPN6(4), RAF1(4), SOCS1(9), SOCS3(1)	2671180	36	17	36	25	6	13	4	7	6	0	0.966	1.000	1.000
394	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ANGPTL2(1), ITPKA(1), ITPKB(5), ITPR1(3), ITPR2(2), MAP2K1(2), PDE3A(6), PIK3C2G(5), PIK3CA(2), PIK3CD(1)	3650365	28	17	28	15	6	4	5	8	5	0	0.864	1.000	1.000
395	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT2(1), ARHGEF11(2), BCL2(1), GNA13(2), LPA(1), MAP2K4(1), MAP3K1(3), MAPK8(1), NFKB1(1), NFKB2(3), NFKBIA(3), NFKBIB(1), PLD1(1), PLD2(2), PTK2(1)	3707665	24	17	23	16	9	2	5	5	3	0	0.954	1.000	1.000
396	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3D(1), CD3G(1), ELK1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK8(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(1), NFKBIA(3), PIK3CA(2), PPP3CA(1), PPP3CC(1), PTPN7(1), RAF1(4), ZAP70(1)	3519620	31	17	30	12	7	6	9	5	4	0	0.464	1.000	1.000
397	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	BCL2(1), BIRC2(1), CASP8(2), MAP2K4(1), MAP3K1(3), MCL1(1), MYC(6), NFKB1(1), NFKBIA(3), PRF1(2), TNF(3), TNFRSF1B(1)	2667773	25	16	24	28	5	3	5	9	3	0	1.000	1.000	1.000
398	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), EGFR(4), ELK1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK8(1), MEF2B(3), PTK2(1), RAF1(4)	2511670	24	16	21	16	3	6	6	7	2	0	0.975	1.000	1.000
399	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BTK(2), CD79A(2), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP3K1(3), MAPK8(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(1), PPP3CC(1), RAF1(4)	2756669	26	16	24	10	6	4	8	4	4	0	0.527	1.000	1.000
400	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(4), EGFR(4), ELK1(1), GRB2(1), JAK1(2), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK8(1), PIK3CA(2), RAF1(4), STAT1(1)	2629914	26	16	24	16	3	11	6	3	3	0	0.938	1.000	1.000
401	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(2), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK8(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PLA2G4A(1), PPP3CA(1), PPP3CC(1), RAF1(4)	3140558	28	16	26	12	6	5	10	4	3	0	0.622	1.000	1.000
402	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(1), AGPAT2(1), CHAT(2), CHKA(1), DGKB(2), DGKD(1), DGKE(1), DGKH(1), DGKQ(1), DGKZ(3), GPD1(1), GPD2(2), LGALS13(1), LYPLA1(1), PCYT1B(1), PEMT(1), PLA2G4A(1), PLA2G5(1), PLCG2(4)	3794789	27	16	27	14	8	4	4	10	1	0	0.874	1.000	1.000
403	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(1), CTPS2(1), DCK(1), DPYD(3), DPYS(1), ENTPD3(1), ENTPD4(1), ENTPD5(2), NT5C(1), NT5C1B(1), NT5M(1), POLD3(1), POLE(2), POLR1A(3), POLR1B(1), POLR2B(1), POLR2E(1), POLR3A(2), RFC5(1), RRM1(1), UPP2(2)	6027791	29	16	29	15	10	3	7	9	0	0	0.844	1.000	1.000
404	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(1), ACACB(6), ACOT12(1), ACSS2(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), DLAT(1), GLO1(1), GRHPR(4), LDHA(1), LDHAL6A(2), MDH2(1), ME2(1), ME3(1), PC(1), PCK2(1), PDHA2(1)	3395782	29	16	28	14	10	4	5	8	2	0	0.813	1.000	1.000
405	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPP(2), ALPPL2(1), ASCC3(1), DDX23(1), DDX41(1), DDX47(2), DDX51(2), DDX52(2), DDX54(2), DDX55(2), ENTPD7(1), EP400(1), ERCC2(1), FPGS(1), GCH1(1), IFIH1(2), NUDT5(1), RAD54B(2), SETX(1), SKIV2L2(1), SMARCA2(2), SMARCA5(1)	4657327	31	16	31	20	11	4	6	5	5	0	0.977	1.000	1.000
406	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(1), ADCY6(1), CACNA1A(2), GNAS(1), GNAT3(1), GRM4(1), PRKACA(1), SCNN1A(2), SCNN1G(1), TAS1R1(1), TAS1R2(3), TAS1R3(1), TAS2R14(1), TAS2R16(2), TAS2R39(1), TAS2R43(1), TAS2R5(1), TAS2R8(1), TRPM5(4)	4332525	27	16	26	14	12	5	1	6	3	0	0.738	1.000	1.000
407	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(4), ELK1(1), GRB2(1), IL6(2), IL6ST(4), JAK1(2), JAK2(2), JAK3(2), MAP2K1(2), RAF1(4)	1661946	24	16	24	11	6	9	3	3	3	0	0.651	1.000	1.000
408	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CLK2(1), COL2A1(1), CPSF1(2), DHX38(1), DHX9(1), NXF1(2), PRPF18(1), PRPF4(1), PTBP1(1), PTBP2(1), RBM17(1), RBM5(1), RNGTT(1), SF3A2(1), SF3B1(2), SNRPD2(1), SPOP(1), SRPK1(1), SRRM1(2)	7805498	24	16	24	29	7	5	5	3	4	0	1.000	1.000	1.000
409	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT2(1), BRD4(2), CBL(1), CDKN2A(1), GRB2(1), IRS4(1), LNPEP(1), PARD3(2), PIK3CA(2), PIK3CD(1), PTEN(2), PTPN1(1), RAF1(4), SFN(2), SLC2A4(1), SOS2(1)	4329199	24	16	24	15	3	10	2	6	3	0	0.891	1.000	1.000
410	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ANGPTL2(1), FLNA(4), FLNC(5), GDI1(1), LIMK1(1), MYH2(1), MYLK(3), PAK4(2), PAK6(1), PAK7(2), PFN1(3), WASF1(1), WASL(1)	3516548	26	16	26	11	8	6	3	7	2	0	0.510	1.000	1.000
411	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(1), AMY2A(1), AMY2B(2), GAA(1), GANAB(2), GBE1(1), HK2(1), HK3(1), MGAM(7), PGM3(1), PYGB(1), PYGL(1), SI(2), UGT1A10(1), UXS1(1)	4897742	24	16	23	17	6	2	6	8	2	0	0.992	1.000	1.000
412	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	IKBKB(2), LTA(1), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAPK8(1), NFKB1(1), NFKBIA(3), TANK(2), TNF(3)	1841230	19	16	18	10	4	1	6	3	5	0	0.792	1.000	1.000
413	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCL2(1), BCR(1), GRB2(1), JAK2(2), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK8(1), MYC(6), PIK3CA(2), RAF1(4), STAT1(1)	2025614	25	15	24	24	2	6	8	8	1	0	0.999	1.000	1.000
414	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), FBP2(2), HK2(1), HK3(1), LDHA(1), LDHAL6A(2), PDHA2(1), PGAM2(1), PGAM4(1), PGK2(1), PGM3(1)	4254169	22	15	22	17	5	4	4	5	4	0	0.981	1.000	1.000
415	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(2), AASS(2), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), EHHADH(2), EHMT1(1), EHMT2(1), HSD17B4(1), HSD3B7(1), NSD1(3), OGDH(1), OGDHL(2), PIPOX(1), PLOD1(1), PLOD2(2), SETD1A(1), SHMT1(1), SHMT2(1), SPCS1(1), SUV39H1(1), SUV39H2(1)	4262125	31	15	31	14	5	8	6	9	3	0	0.763	1.000	1.000
416	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ALDH1A3(1), AOC2(1), DCT(1), DDC(1), HEMK1(1), LCMT1(1), LCMT2(1), PRMT2(1), PRMT8(1), TAT(1), TPO(4), TYR(2), TYRP1(1)	4320695	17	15	17	20	8	3	3	2	1	0	0.998	1.000	1.000
417	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	AGPAT1(1), AGPAT2(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), CEL(1), DGKB(2), DGKD(1), DGKE(1), DGKH(1), DGKI(5), DGKQ(1), DGKZ(3), GPAM(1), LCT(1), PNLIPRP1(1)	4395822	25	15	25	16	5	7	3	8	2	0	0.928	1.000	1.000
418	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	AKR1C1(1), AKR1C2(2), AKR1C3(2), AKR1C4(1), ALDH1A3(1), CYP1A2(1), CYP2B6(1), CYP2C19(1), CYP2C8(2), CYP2C9(1), CYP3A4(1), CYP3A43(2), CYP3A5(3), EPHX1(1), GSTA3(2), GSTA4(1), UGT1A10(1), UGT2B11(1), UGT2B17(2), UGT2B7(2)	4125662	29	15	29	13	2	6	7	6	8	0	0.763	1.000	1.000
419	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(3), BCAR1(1), BCR(1), CAV1(1), CSK(3), GRB2(1), MAP2K1(2), MAPK8(1), PTK2(1), RAF1(4), TLN1(3)	3511825	21	15	19	16	3	5	5	6	2	0	0.988	1.000	1.000
420	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	CAV1(1), CHRNA1(1), FLT1(2), KDR(6), PDE3A(6), PRKG1(2), PRKG2(1), RYR2(2), SLC7A1(1)	3104373	22	15	20	15	2	2	5	11	2	0	0.981	1.000	1.000
421	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT2(1), BCR(1), BTK(2), CDKN2A(1), GAB1(1), ITPR1(3), ITPR2(2), LYN(2), PIK3CA(2), PITX2(1), PLCG2(4), PREX1(1), PTEN(2), PTPRC(1)	4072491	24	15	23	11	6	3	5	5	5	0	0.627	1.000	1.000
422	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B3(2), EIF2B4(2), EIF2B5(2), EIF2S2(1), ELAVL1(1), FLT1(2), KDR(6), PIK3CA(2), PTK2(1)	2546146	19	15	17	11	3	2	4	10	0	0	0.931	1.000	1.000
423	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(1), AGTR2(3), CAMK2G(1), GNGT1(1), GRB2(1), JAK2(2), MAP2K1(2), MAPK8(1), MYLK(3), RAF1(4), STAT1(1)	2994125	20	14	20	17	5	5	4	5	1	0	0.989	1.000	1.000
424	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	26	BRCA1(2), CREBBP(6), EP300(3), GRIP1(1), GTF2A1(1), GTF2F1(3), HDAC2(2), NCOR2(4), NR0B1(2), NRIP1(1), PELP1(2), TBP(1)	3571992	28	14	28	18	6	5	4	8	5	0	0.962	1.000	1.000
425	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	MAP2K1(2), MYC(6), NFKB1(1), NFKBIA(3), PLCB1(5), RAF1(4), TNF(3)	1124288	24	14	24	13	2	5	4	8	5	0	0.882	1.000	1.000
426	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(1), GRB2(1), INSR(1), JAK2(2), MAP2K1(2), PIK3CA(2), PTPN6(4), RAF1(4), SLC2A4(1), SOCS1(9)	2443030	28	14	28	18	3	11	4	5	5	0	0.928	1.000	1.000
427	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ALAS2(1), AMT(1), AOC2(1), CBS(2), CHKA(1), DAO(2), DMGDH(1), GARS(1), GCAT(1), PEMT(1), PLCG2(4), PSPH(1), SARDH(1), SHMT1(1), SHMT2(1)	3139026	20	14	20	13	9	2	3	4	2	0	0.920	1.000	1.000
428	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	BCL2(1), BIRC2(1), CASP8(2), DFFA(1), GSN(1), MAP3K1(3), MAPK8(1), NFKB1(1), NFKBIA(3), NUMA1(2), PRKCD(1), PSEN1(1), PTK2(1), RB1(1), SPTAN1(1), TNF(3), TNFRSF1B(1)	5125987	25	14	24	30	5	4	6	6	4	0	1.000	1.000	1.000
429	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), CYP11B1(1), HEMK1(1), HSD17B1(2), HSD3B2(2), LCMT1(1), LCMT2(1), PRMT2(1), PRMT8(1), SULT2B1(1), UGT1A10(1), UGT2B11(1), UGT2B17(2), UGT2B7(2)	3537887	18	14	17	11	6	5	3	0	4	0	0.831	1.000	1.000
430	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ALAS2(1), AMT(1), AOC2(1), CBS(2), CHKA(1), DAO(2), DMGDH(1), GARS(1), GCAT(1), HSD3B7(1), PEMT(1), PIPOX(1), PSPH(1), SARDH(1), SHMT1(1), SHMT2(1)	3194363	18	14	18	15	10	2	3	2	1	0	0.980	1.000	1.000
431	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	67	CANX(1), CD8B(1), HLA-DMA(1), HLA-DMB(1), HLA-DPA1(2), HLA-DQB1(1), HLA-DRB5(4), HLA-G(1), HSP90AA1(1), IFNA1(1), IFNA10(2), IFNA13(1), IFNA17(1), IFNA4(1), IFNA5(1), KIR3DL1(1), KIR3DL2(1), KLRC4(1), LTA(1), NFYA(1), NFYC(2), PDIA3(1), RFX5(1), RFXANK(1), TAP1(1)	3075755	31	14	31	15	7	6	4	8	6	0	0.775	1.000	1.000
432	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(3), ACTB(5), ARHGEF2(2), CDH1(1), CTTN(1), EZR(1), NCL(2), RHOA(2), TLR4(2), TUBA3D(1), TUBA8(2), TUBB1(1), WAS(1), WASL(1)	3786024	25	14	25	23	9	4	2	6	4	0	1.000	1.000	1.000
433	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(3), ACTB(5), ARHGEF2(2), CDH1(1), CTTN(1), EZR(1), NCL(2), RHOA(2), TLR4(2), TUBA3D(1), TUBA8(2), TUBB1(1), WAS(1), WASL(1)	3786024	25	14	25	23	9	4	2	6	4	0	1.000	1.000	1.000
434	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	DOCK1(3), ELK1(1), GAB1(1), GRB2(1), MAP2K1(2), MAP4K1(1), MAPK8(1), MET(2), PIK3CA(2), PTEN(2), PTK2(1), RAF1(4)	3225592	21	14	21	26	1	9	4	4	3	0	1.000	1.000	1.000
435	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	IKBKB(2), IL1A(1), IL1R1(1), MAP3K1(3), NFKB1(1), NFKBIA(3), TLR4(2), TNF(3), TNFRSF1B(1), TRAF6(1)	1691438	18	14	17	12	5	2	4	4	3	0	0.922	1.000	1.000
436	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(4), ESR2(1), NR0B1(2), NR2F2(1), PGR(2), PPARG(1), THRA(1), THRB(2)	3152858	17	14	17	24	4	4	1	5	3	0	1.000	1.000	1.000
437	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(8), CCND2(1), EGR1(1), ESR2(1), GJA4(1), INHA(2), MLH1(5), NCOR1(1), NRIP1(1), PGR(2), ZP2(1)	2543618	24	14	20	13	2	6	12	4	0	0	0.766	1.000	1.000
438	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ELK1(1), GRB2(1), MAP2K4(1), MAP3K1(3), MAPKAPK2(1), MEF2B(3), MKNK1(1), MYC(6), PLA2G4A(1), RPS6KA5(1), STAT1(1), TGFB2(1)	2755235	21	14	19	17	2	5	5	7	2	0	0.992	1.000	1.000
439	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(4), ELK1(1), GRB2(1), JAK1(2), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK8(1), PIK3CA(2), RAF1(4), STAT1(1)	2452743	22	14	21	13	2	9	6	2	3	0	0.895	1.000	1.000
440	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(1), CTPS2(1), DCK(1), DPYD(3), DPYS(1), NT5C(1), NT5M(1), POLE(2), POLG(1), POLQ(6), POLR1B(1), POLR2B(1), POLR2E(1), POLRMT(3), RRM1(1)	4277682	25	14	25	15	3	8	5	9	0	0	0.902	1.000	1.000
441	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BIRC2(1), CASP8(2), MAP2K4(1), NFKB1(1), NFKB2(3), NFKBIA(3), NFKBIB(1), RALBP1(1), TNF(3), TNFRSF1B(1)	1932946	17	14	17	10	5	3	2	4	3	0	0.877	1.000	1.000
442	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	BCL2(1), EGFR(4), MYC(6), PPP2CA(1), RB1(1), TEP1(2), TNKS(2), XRCC5(2)	1969938	19	14	18	20	4	4	2	7	2	0	0.999	1.000	1.000
443	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), ELK1(1), EPOR(1), GRB2(1), JAK2(2), MAP2K1(2), MAPK8(1), PTPN6(4), RAF1(4)	1616140	20	13	20	10	2	6	4	4	4	0	0.767	1.000	1.000
444	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(3), ATM(8), ATR(2), CDKN1A(2), CDKN2A(1), CDKN2B(1), E2F1(2), RB1(1), SKP2(1), TGFB2(1)	2141217	22	13	20	15	5	4	7	3	3	0	0.962	1.000	1.000
445	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), FBP2(2), HK2(1), HK3(1), LDHA(1), PDHA2(1), PGM3(1)	3563180	16	13	16	11	4	4	3	3	2	0	0.906	1.000	1.000
446	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	AGPAT1(1), AGPAT2(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), CEL(1), DGKB(2), DGKD(1), DGKE(1), DGKH(1), DGKQ(1), DGKZ(3), LCT(1), PNLIPRP1(1)	3629870	19	13	19	12	5	6	2	5	1	0	0.855	1.000	1.000
447	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), FBP2(2), HK2(1), HK3(1), LDHA(1), PDHA2(1), PGM3(1)	3563180	16	13	16	11	4	4	3	3	2	0	0.906	1.000	1.000
448	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(3), EPHB2(1), ITPKA(1), ITPKB(5), MAP2K4(1), MAPK8(1), MAPK8IP1(1)	2114383	13	13	13	14	1	4	3	3	2	0	0.997	1.000	1.000
449	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(1), CISH(1), GRB2(1), IL13RA1(1), IL4R(1), JAK1(2), JAK2(2), JAK3(2), PIK3CA(2), SOS2(1), STAT6(4), TYK2(1)	2707386	19	13	19	13	4	4	3	7	1	0	0.945	1.000	1.000
450	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	DUSP4(2), DUSP8(1), GAB1(1), IL1R1(1), MAP2K4(1), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K4(1), MAPK7(1), MAPK8(1), NFATC3(1), PAPPA(3), TRAF6(1)	3638958	19	13	18	20	6	3	4	6	0	0	0.999	1.000	1.000
451	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(3), CDKN2A(1), E2F1(2), MYC(6), PIK3CA(2), POLR1A(3), POLR1B(1), RB1(1)	1408115	19	12	19	16	4	2	5	6	2	0	0.995	1.000	1.000
452	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	AGT(1), AGTR2(3), EDNRA(1), EGFR(4), MYC(6), NFKB1(1)	1485033	16	12	15	18	3	3	2	8	0	0	0.999	1.000	1.000
453	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	ATM(8), BCL2(1), PTK2(1), STAT1(1), TLN1(3)	1934847	14	12	12	11	2	5	5	2	0	0	0.935	1.000	1.000
454	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CXCR4(3), GNGT1(1), MAP2K1(2), NFKB1(1), PIK3C2G(5), PIK3CA(2), PTK2(1), RAF1(4)	2083046	20	12	20	11	4	6	3	7	0	0	0.860	1.000	1.000
455	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(4), MAP2K1(2), MAP3K1(3), NCOR2(4), THRA(1), THRB(2)	1301855	16	12	14	11	4	5	3	3	1	0	0.927	1.000	1.000
456	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), FBP2(2), HK2(1), HK3(1), LDHA(1), MDH2(1), PC(1), PDHA2(1), PGAM2(1), PGK2(1)	3067490	14	12	14	11	4	1	3	4	2	0	0.956	1.000	1.000
457	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCRL(2), EMR2(1), GLP2R(1), LPHN1(1), LPHN2(3), LPHN3(1), SCTR(1), VIPR2(1)	2053320	14	12	14	10	4	2	3	4	1	0	0.953	1.000	1.000
458	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ELK1(1), GNAS(1), GNGT1(1), MAP2K1(2), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(1), PPP3CC(1), RAF1(4)	2587317	17	12	17	12	6	4	4	2	1	0	0.925	1.000	1.000
459	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOB(1), ALDOC(1), FBP2(2), FPGT(1), FUK(2), HK2(1), HK3(1), HSD3B7(1), MTMR1(3), PHPT1(1), PMM2(1)	2779768	15	12	15	10	6	1	2	4	2	0	0.900	1.000	1.000
460	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAD8(1), AKR1C4(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), BAAT(1), CEL(1), HSD3B7(1), SLC27A5(4)	2344992	15	12	15	10	6	3	1	4	1	0	0.891	1.000	1.000
461	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), CYP1A2(1), DDC(1), EHHADH(2), HEMK1(1), HSD17B4(1), INMT(1), LCMT1(1), LCMT2(1), LNX1(1), OGDH(1), OGDHL(2), PRMT2(1), PRMT8(1), TDO2(1)	4422017	22	12	22	12	7	4	4	6	1	0	0.823	1.000	1.000
462	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT2(1), BRAF(3), PDPK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PRKAA1(1), RICTOR(1), RPS6KA6(1), ULK1(1), ULK2(1), ULK3(1), VEGFB(1), VEGFC(1)	4010905	17	12	17	17	5	3	4	3	2	0	0.998	1.000	1.000
463	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(3), C5(2), C6(3), C7(1), IL1A(1), IL6(2), ITGA4(2), TNF(3), VCAM1(1)	1800032	18	12	18	12	6	4	2	4	2	0	0.888	1.000	1.000
464	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(3), CREBBP(6), DVL1(1), EP300(3), FZD1(1), PITX2(1)	2430669	15	12	15	11	3	1	3	6	2	0	0.971	1.000	1.000
465	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), GRB2(1), MAP2K1(2), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAPK8(1), RAF1(4)	2100377	15	12	14	11	2	3	7	1	2	0	0.951	1.000	1.000
466	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(1), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP3K1(3), PAPPA(3), VAV3(1)	2369020	14	12	12	13	5	2	4	2	1	0	0.989	1.000	1.000
467	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(1), BCL2(1), GRB2(1), IL4R(1), JAK1(2), JAK3(2), MAP4K1(1), PIK3CA(2), PIK3CD(1), RAF1(4), SOCS1(9), SOS2(1), STAT6(4)	2709873	30	12	30	15	6	12	5	3	4	0	0.619	1.000	1.000
468	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2G(1), ITPKA(1), ITPKB(5), ITPR1(3), ITPR2(2), PDE6A(1), PDE6H(1), SLC6A13(2)	2666040	16	12	16	13	3	3	3	2	5	0	0.961	1.000	1.000
469	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	MAP3K1(3), MYC(6), NFATC1(2), NFATC2(2), NFKB1(1), NFKBIA(3), PPP3CA(1), PPP3CC(1), VIPR2(1)	2047935	20	12	19	14	4	1	6	7	2	0	0.952	1.000	1.000
470	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	GNGT1(1), ITGB3(1), PIK3CA(2), PLCB1(5), PTK2(1), SMPD2(1), SPHK1(1)	1985882	12	11	12	16	3	1	0	4	4	0	1.000	1.000	1.000
471	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(1), ALPP(2), ALPPL2(1), CYP1A2(1), CYP2A13(1), CYP2A6(1), CYP2B6(1), CYP2C19(1), CYP2C8(2), CYP2C9(1), CYP2D6(2), CYP2J2(1), CYP3A4(1), CYP3A5(3), PON1(2)	2173728	21	11	21	12	4	4	3	6	4	0	0.883	1.000	1.000
472	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(1), ACACB(6), ACADM(1), ACSS2(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), EHHADH(2), LDHA(1), LDHAL6A(2), MCEE(1), MUT(1), PCCA(1), PCCB(1), SUCLG2(1)	2888515	24	11	23	10	7	3	8	3	3	0	0.671	1.000	1.000
473	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), CAMK2G(1), CLCA2(2), CLCA4(3), CNGB1(2), GUCA1C(1), PDE1C(3), PRKACA(1), PRKG1(2), PRKG2(1)	2276287	17	11	17	11	2	5	2	7	1	0	0.941	1.000	1.000
474	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A3(1), COL4A4(2), COL4A5(1), F10(1), F11(1), F12(1), F2R(1), F5(1), F8(1), FGG(1), KLKB1(1), PROC(1)	3290647	14	11	14	11	6	3	0	4	1	0	0.966	1.000	1.000
475	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGFR(4), GRB2(1), MAP2K1(2), RAF1(4), SPRY3(1)	1828397	13	11	12	17	2	6	2	2	1	0	1.000	1.000	1.000
476	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), APC(3), EPHB2(1), ITPR1(3), ITPR2(2), KCNJ3(1), PITX2(1), PTX3(1), RYR1(2)	3412968	15	11	15	16	3	3	3	4	2	0	0.996	1.000	1.000
477	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT2(1), APC(3), AXIN2(1), CSNK1A1(2), DACT1(1), DVL1(1), LRP1(3), MVP(2), NKD2(2), PSEN1(1), PTPRA(1)	3007405	18	11	18	23	7	4	0	5	2	0	1.000	1.000	1.000
478	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	IKBKB(2), JAK2(2), NFKB1(1), NFKBIA(3), RB1(1), TNF(3), TNFRSF1B(1)	1349903	13	11	13	13	2	2	1	4	4	0	0.993	1.000	1.000
479	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKB(2), LTA(1), MAP3K1(3), NFKB1(1), NFKBIA(3), TANK(2), TNFRSF1B(1)	1588397	13	11	12	10	4	1	3	2	3	0	0.958	1.000	1.000
480	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(4), GRB2(1), JAK2(2), MAP2K1(2), PIK3CA(2), RAF1(4), STAT1(1)	2079522	16	11	16	11	1	7	2	3	3	0	0.951	1.000	1.000
481	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	21	F10(1), F11(1), F12(1), F13B(1), F5(1), F7(1), F8(1), FGG(1), LPA(1), PLAT(1), PLG(1), SERPINB2(1), VWF(5)	2649739	17	10	17	10	10	2	1	4	0	0	0.885	1.000	1.000
482	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BCL2(1), CASP8(2), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK8(1), NFKB1(1), RAF1(4)	1497609	15	10	14	14	3	3	7	1	1	0	0.990	1.000	1.000
483	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	MCM10(2), MCM4(1), POLD3(1), POLE(2), RFC4(2), RFC5(1), UBB(1)	3749026	10	10	10	11	3	1	1	3	2	0	0.997	1.000	1.000
484	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	APC(3), DVL1(1), FZD1(1), LBP(1), NFKB1(1), PDPK1(1), PIK3CA(2), PPP2CA(1), TIRAP(1), TLR4(2)	2258359	14	10	14	18	2	3	3	5	1	0	1.000	1.000	1.000
485	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(1), ACP6(1), ALPP(2), ALPPL2(1), CYP3A4(1), CYP3A43(2), CYP3A5(3), DHRS2(2), PON1(2), PON2(1)	1357289	16	10	16	11	2	2	1	6	5	0	0.969	1.000	1.000
486	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GNT1(1), B3GNT4(1), B3GNT5(2), B4GALNT1(1), B4GALT3(1), FUT4(1), FUT5(1), GBGT1(2), PIGB(1), PIGC(1), PIGF(1), PIGL(1), PIGP(1), PIGS(1), PIGZ(1)	3632832	18	10	17	14	5	1	4	4	4	0	0.975	1.000	1.000
487	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN2(1), EGFR(4), MYLK(3), PTK2(1), TLN1(3)	2464145	12	10	11	15	5	4	1	2	0	0	0.999	1.000	1.000
488	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CDKN1A(2), E2F1(2), NFKB1(1), NFKBIA(3), PIK3CA(2), RAF1(4), RB1(1)	1489831	15	10	15	12	3	5	2	2	3	0	0.962	1.000	1.000
489	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	ELK1(1), IL1R1(1), MAP2K3(2), MAP2K4(1), MAP3K10(1), MAP3K4(1), MAPK11(1), MAPKAPK2(1), MKNK1(1), NFKB1(1), TRAF6(1)	2532189	12	10	12	12	5	2	3	1	1	0	0.984	1.000	1.000
490	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), CYP1A2(1), CYP2A13(1), CYP2A6(1), CYP2B6(1), CYP2C19(1), CYP2C8(2), CYP2C9(1), CYP2D6(2), CYP2J2(1), CYP3A4(1), CYP3A5(3), DDC(1), EHHADH(2), TDO2(1)	4022322	25	10	25	10	6	6	4	5	4	0	0.514	1.000	1.000
491	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ALDH1A3(1), AOC2(1), DCT(1), DDC(1), TAT(1), TPO(4), TYR(2)	2303781	11	10	11	14	6	1	2	1	1	0	0.995	1.000	1.000
492	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A3(1), ALDH3A2(2), ALDH4A1(1), ALDH9A1(2), AOC2(1), CKM(1), CPS1(1), DAO(2), NOS1(1), OTC(1), P4HA3(1)	3328985	15	9	15	10	7	3	0	3	2	0	0.895	1.000	1.000
493	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	CS(2), IDH1(1), IDH3A(1), IDH3B(1), MDH2(1), OGDH(1), OGDHL(2), PC(1), PCK2(1), SDHC(1), SUCLG2(1)	2163943	13	9	13	10	2	2	2	6	1	0	0.957	1.000	1.000
494	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADL(1), ACADM(1), ACADVL(1), ACOX1(3), ACSL3(2), ACSL5(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), CPT1C(1), CPT2(1), CYP4A22(1), EHHADH(2), HSD17B4(1)	3583464	21	9	21	12	5	5	6	3	2	0	0.837	1.000	1.000
495	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS2(2), ADSSL1(1), CAD(1), DARS2(1), DLAT(1), GAD1(2), GAD2(1), NARS2(1), PC(1), PDHA2(1)	2795367	12	9	12	8	5	1	3	3	0	0	0.878	1.000	1.000
496	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(1), ACADM(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), BCAT2(1), BCKDHA(1), BCKDHB(1), EHHADH(2), HMGCS2(1), HSD17B4(1), MCCC1(2), MCCC2(1), MCEE(1), MUT(1), OXCT1(2), PCCA(1), PCCB(1)	3223373	23	9	23	11	7	3	7	3	3	0	0.721	1.000	1.000
497	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(1), CHIT1(1), CTBS(1), CYB5R3(1), GFPT1(1), HK2(1), HK3(1), MTMR1(3), PGM3(1), PHPT1(1)	2117481	13	9	13	11	5	1	2	3	2	0	0.978	1.000	1.000
498	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(2), DLAT(1), IDH3A(1), IDH3B(1), MDH2(1), OGDH(1), PC(1), PDHA2(1), SDHC(1), SUCLG2(1)	2087926	11	9	11	10	2	1	3	4	1	0	0.972	1.000	1.000
499	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(3), DUSP4(2), GRB2(1), MAP2K1(2), MKNK1(1), MOS(1), NFKB1(1), SOS2(1)	2214013	12	9	12	12	4	3	3	1	1	0	0.985	1.000	1.000
500	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADL(1), ACADM(1), ALDH1A3(1), ALDH3A2(2), ALDH9A1(2), BCKDHA(1), BCKDHB(1), EHHADH(2), MCCC1(2), MCCC2(1), MCEE(1), MUT(1), OXCT1(2), PCCA(1), PCCB(1)	2666035	21	9	21	10	6	4	6	2	3	0	0.700	1.000	1.000
501	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(3), BMP10(2), BMP2(1), BMP5(1), BMP7(1), CHRD(3), DVL1(1), FZD1(1), NKX2-5(1), TGFB2(1), TGFBR3(2)	2695065	17	8	16	12	6	4	2	5	0	0	0.960	1.000	1.000
502	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), EGFR(4), GRB2(1), MET(2), SH3GLB2(1)	1409572	9	8	8	30	1	5	1	1	1	0	1.000	1.000	1.000
503	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BCL2(1), BIRC2(1), CASP8(2), DFFA(1), NFKB1(1), NFKBIA(3), SPTAN1(1)	2478464	10	8	10	17	3	0	3	2	2	0	1.000	1.000	1.000
504	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	E2F1(2), ETS1(1), ETS2(2), HDAC2(2), NCOR2(4)	2019780	11	8	11	14	4	2	0	4	1	0	0.999	1.000	1.000
505	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(2), MAP2K3(2), MAP3K1(3), NFKB1(1), PIK3CA(2), RB1(1)	1441506	11	8	10	10	1	1	5	2	2	0	0.987	1.000	1.000
506	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	GAA(1), GALK2(1), GANC(1), HK2(1), HK3(1), HSD3B7(1), LALBA(1), LCT(1), MGAM(7), PGM3(1)	2828641	16	8	16	10	4	2	3	4	3	0	0.935	1.000	1.000
507	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	40	ADCY3(1), ADCY9(1), ATP6V0A1(2), ATP6V0A4(1), ATP6V0D2(1), ATP6V1G3(1), GNAS(1), PDIA4(2), PLCG2(4), SEC61A1(1), TRIM23(1)	2671635	16	8	16	10	7	2	3	3	1	0	0.868	1.000	1.000
508	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A2(1), EIF4G1(1), EIF4G2(1), EIF4G3(1), MKNK1(1), PDPK1(1), PIK3CA(2), PPP2CA(1), PTEN(2)	2061261	11	8	11	11	1	2	1	5	2	0	0.996	1.000	1.000
509	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	ELK1(1), MAP2K1(2), NFKB1(1), PIK3CA(2), RAF1(4), RALBP1(1), RALGDS(1), RHOA(2)	1448425	14	8	14	11	4	6	3	1	0	0	0.924	1.000	1.000
510	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(2), JAK2(2), JAK3(2), PIAS1(1), PTPRU(1)	1038087	9	8	9	5	3	1	1	4	0	0	0.854	1.000	1.000
511	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	CISH(1), IL6(2), JAK1(2), JAK2(2), JAK3(2), PTPRU(1)	1022685	10	8	10	5	4	1	1	4	0	0	0.793	1.000	1.000
512	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP8(2), DFFA(1), MAP2K4(1), MAP3K1(3), MAPK8(1), RB1(1), SPTAN1(1), TNF(3)	2935882	13	8	12	15	1	1	6	2	3	0	0.999	1.000	1.000
513	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(2), DDC(1), GAD1(2), GAD2(1), HDC(1), PAH(1)	1060398	8	7	8	11	3	2	1	2	0	0	0.995	1.000	1.000
514	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	GRB2(1), MAPK7(1), MEF2B(3), NTRK1(1), PIK3CA(2)	1459328	8	7	7	10	1	2	0	3	2	0	0.997	1.000	1.000
515	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP8(2), DFFA(1), FAF1(1), MAP2K4(1), MAP3K1(3), MAPK8(1), PTPN13(1), RB1(1), SPTAN1(1)	3154006	12	7	11	13	2	0	6	2	2	0	0.997	1.000	1.000
516	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	CS(2), GRHPR(4), HAO1(1), HYI(1), MDH2(1)	922493	9	7	9	7	1	1	0	7	0	0	0.974	1.000	1.000
517	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), ALDOC(1), DERA(1), FBP2(2), PGD(1), PGM3(1)	1789884	7	7	7	5	1	3	2	1	0	0	0.812	1.000	1.000
518	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP6V0A1(2), ATP6V0A4(1), ATP6V0D2(1), ATP6V1G3(1), COX7B(1), NDUFA9(1), NDUFS1(1), NDUFS4(1), NDUFV2(1), PPA2(1), SDHC(1), UQCRH(1)	4188997	14	7	14	11	4	2	2	4	2	0	0.975	1.000	1.000
519	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), CKM(1), CPS1(1), DAO(2), LAP3(1), NOS1(1), OTC(1), P4HA3(1), RARS2(1)	2729647	10	7	10	10	5	2	1	1	1	0	0.979	1.000	1.000
520	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), GALNT1(1), GALNT10(1), GALNT2(1), GALNT4(1), GALNT8(2), GCNT1(2), WBSCR17(1)	2371249	10	7	10	14	1	5	0	4	0	0	0.999	1.000	1.000
521	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ENPP7(2), GAL3ST1(1), GBA(2), LCT(1), NEU2(1), SGPP1(1), SMPD2(1), SPHK1(1), SPHK2(1)	2650200	11	7	11	11	5	1	2	1	2	0	0.984	1.000	1.000
522	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	CS(2), GRHPR(4), HAO1(1), HYI(1), MDH2(1)	968063	9	7	9	7	1	1	0	7	0	0	0.973	1.000	1.000
523	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(2), CARS2(3), DARS2(1), FARSB(1), GARS(1), NARS2(1), QARS(1), RARS2(1), VARS(1), VARS2(1)	3934887	13	7	13	11	4	3	1	3	2	0	0.983	1.000	1.000
524	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN2A(2), GRIN2B(2), GRIN2C(1), GRIN2D(1), NOS1(1), PPP3CA(1), PPP3CC(1)	1912188	9	7	9	10	5	1	2	0	1	0	0.970	1.000	1.000
525	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(1), GALNT2(1), GALNT4(1), GALNT8(2), GCNT1(2), WBSCR17(1)	1076400	9	7	9	8	1	4	0	4	0	0	0.960	1.000	1.000
526	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(1), CDKN1A(2), ELK1(1), GRB2(1), MAP2K1(2), NGFR(2), NTRK1(1), PIK3CA(2), PIK3CD(1)	1236506	13	7	13	10	5	3	2	1	2	0	0.935	1.000	1.000
527	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(1), APOA1(1), APOA4(1), APOC2(1), CETP(2), HMGCR(1), LRP1(3)	1991949	10	7	10	11	5	2	1	2	0	0	0.981	1.000	1.000
528	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(3), ITGB3(1), PTK2(1), SPTAN1(1), TLN1(3)	2124621	9	7	7	8	2	2	1	4	0	0	0.981	1.000	1.000
529	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	NCKAP1(1), NTRK1(1), WASF1(1), WASF3(2), WASL(1)	1125112	6	6	6	4	2	1	1	2	0	0	0.886	1.000	1.000
530	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	CS(2), IDH1(1), IDH3A(1), IDH3B(1), MDH2(1), PC(1), SUCLG2(1)	1500331	8	6	8	7	1	2	2	3	0	0	0.956	1.000	1.000
531	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	CAMK2G(1), GNAS(1), GRB2(1), PIK3CA(2), RPS6KA5(1)	2173768	6	6	6	12	1	3	0	1	1	0	0.999	1.000	1.000
532	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGFR(4), HGS(1)	929705	6	6	5	10	1	4	0	1	0	0	0.998	1.000	1.000
533	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	RPL13(1), RPL3(1), RPL37(1), RPL3L(2), RPL6(1)	1559020	6	6	6	8	3	2	1	0	0	0	0.992	1.000	1.000
534	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	BCL2(1), IL1A(1), MAPKAPK2(1), TNF(3)	766358	6	6	6	10	2	2	0	1	1	0	0.997	1.000	1.000
535	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), ALDOC(1), FBP2(2), PGD(1), PGM3(1)	1479934	6	6	6	4	1	3	1	1	0	0	0.755	1.000	1.000
536	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK1(2), JAK2(2), TYK2(1)	764587	7	6	7	7	1	1	1	4	0	0	0.984	1.000	1.000
537	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK1(2), JAK2(2), TYK2(1)	764587	7	6	7	7	1	1	1	4	0	0	0.984	1.000	1.000
538	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	6	JAK1(2), JAK2(2), JAK3(2), TYK2(1)	779117	7	6	7	6	3	1	0	3	0	0	0.954	1.000	1.000
539	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	CAD(1), GAD1(2), GAD2(1), PC(1)	1913999	5	5	5	5	2	1	0	2	0	0	0.945	1.000	1.000
540	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), CYP11B1(1), HSD3B2(2), UGT1A10(1)	1966703	5	5	5	9	2	2	1	0	0	0	0.997	1.000	1.000
541	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	BCL2(1), IL3RA(1), KITLG(1), PIK3CA(2)	1610040	5	5	5	11	1	1	0	3	0	0	1.000	1.000	1.000
542	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(4), NRG1(2)	739620	6	5	4	6	1	2	0	3	0	0	0.984	1.000	1.000
543	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F2R(1), FGG(1), PLAT(1), PLG(1), SERPINB2(1)	974522	5	5	5	4	1	2	0	2	0	0	0.931	1.000	1.000
544	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(1), FDFT1(1), GGPS1(1), HMGCR(1), LSS(2), NQO1(1), NSDHL(1)	1442027	8	5	8	6	2	3	1	2	0	0	0.869	1.000	1.000
545	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(3), DVL1(1), FZD1(1), NOTCH1(1), PSEN1(1)	1638098	7	5	7	18	1	2	1	2	1	0	1.000	1.000	1.000
546	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), JAK1(2), JAK2(2), PTPRU(1), STAT1(1)	836344	7	5	7	6	1	2	0	4	0	0	0.958	1.000	1.000
547	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAPK8(1), NFKB1(1), TNFRSF13B(2), TNFSF13B(1), TRAF6(1)	1058732	6	5	6	4	2	0	3	1	0	0	0.884	1.000	1.000
548	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11B1(1), HSD3B2(2)	662195	4	4	4	3	1	2	1	0	0	0	0.762	1.000	1.000
549	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	GNAS(1), GNGT1(1), NFKB1(1), PIK3CA(2)	1339315	5	4	5	8	2	1	1	1	0	0	0.995	1.000	1.000
550	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11B1(1), HSD3B2(2)	662195	4	4	4	3	1	2	1	0	0	0	0.762	1.000	1.000
551	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(1), NAT1(1)	583688	4	4	4	6	0	2	0	2	0	0	0.990	1.000	1.000
552	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(1), PDHA2(1), VARS(1), VARS2(1)	1352774	4	4	4	6	1	1	1	1	0	0	0.988	1.000	1.000
553	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC1(1), APOBEC3C(1), APOBEC3F(1), APOBEC3G(1)	527269	5	4	5	5	1	1	2	1	0	0	0.959	1.000	1.000
554	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ANKRD1(1), IL1A(1), IL1R1(1), MYOG(1)	810356	4	4	4	3	3	0	0	1	0	0	0.848	1.000	1.000
555	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(2), JAK2(2), STAT1(1)	592569	5	4	5	6	1	2	0	2	0	0	0.980	1.000	1.000
556	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	CDC25C(2), GNAS(1), GNGT1(1), MYT1(1)	1534712	5	4	5	11	3	0	0	2	0	0	1.000	1.000	1.000
557	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), GREB1(1), TUBA8(2)	848385	4	4	4	4	2	0	0	2	0	0	0.929	1.000	1.000
558	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25C(2), SHH(1), XPO1(2)	639780	5	4	5	4	3	0	0	2	0	0	0.938	1.000	1.000
559	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(1), MAPK8(1), NFKB1(1), TNFRSF11A(1), TRAF6(1)	800175	5	4	5	4	3	0	2	0	0	0	0.857	1.000	1.000
560	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B1(2), HSD17B4(1), HSD3B2(2)	589135	6	4	5	4	3	1	2	0	0	0	0.765	1.000	1.000
561	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CR1(1), CR2(1), FCGR2B(1), PTPRC(1)	1201244	4	3	4	3	0	1	1	2	0	0	0.890	1.000	1.000
562	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	PIK3CA(2), WASL(1)	981086	3	3	3	4	0	1	0	2	0	0	0.982	1.000	1.000
563	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	GNAS(1), GNGT1(1), PPP2CA(1), PRKAA1(1)	1146405	4	3	4	6	2	2	0	0	0	0	0.984	1.000	1.000
564	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	GNAS(1), GNGT1(1), PRKACA(1)	489989	3	3	3	3	3	0	0	0	0	0	0.943	1.000	1.000
565	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	CHST11(1), CHST12(2), DSE(1), UST(1), XYLT1(2), XYLT2(1)	1072776	8	3	7	5	0	1	0	7	0	0	0.903	1.000	1.000
566	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	DHRS2(2), EHHADH(2)	1885055	4	3	4	5	0	0	2	2	0	0	0.985	1.000	1.000
567	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(1), PLA1A(2)	1854740	4	3	4	3	1	1	1	1	0	0	0.854	1.000	1.000
568	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(1), LEPR(1), PRKAA1(1)	1041897	3	3	3	5	0	3	0	0	0	0	0.988	1.000	1.000
569	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ITGA4(2)	892169	3	3	3	7	1	1	0	1	0	0	0.997	1.000	1.000
570	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ITGA4(2)	1185802	3	3	3	7	1	1	0	1	0	0	0.997	1.000	1.000
571	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	FURIN(2), NOTCH1(1), PSEN1(1)	740733	4	3	4	11	2	1	0	0	1	0	1.000	1.000	1.000
572	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	GNAS(1), PLCE1(2)	1114755	3	3	3	5	2	1	0	0	0	0	0.979	1.000	1.000
573	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), CP(1), UGT1A10(1), UROS(1)	1959904	4	3	4	4	3	0	1	0	0	0	0.952	1.000	1.000
574	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP2(1), RECK(1), TIMP4(1)	567106	3	3	3	3	0	0	0	3	0	0	0.982	1.000	1.000
575	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MYC(6)	453360	6	3	6	6	0	1	1	4	0	0	0.974	1.000	1.000
576	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(1), GNGT1(1)	732388	2	2	2	3	2	0	0	0	0	0	0.965	1.000	1.000
577	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	GARS(1), QARS(1)	2301515	2	2	2	4	1	0	0	1	0	0	0.991	1.000	1.000
578	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP3(1), CLTB(1), COPA(1)	1176426	3	2	3	3	1	1	1	0	0	0	0.910	1.000	1.000
579	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK2G(1), CAMK4(1)	875442	2	2	2	6	0	1	0	1	0	0	0.999	1.000	1.000
580	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(1), PYGL(1)	1013251	2	2	2	4	0	1	0	1	0	0	0.977	1.000	1.000
581	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(1)	674641	2	2	2	2	0	0	1	1	0	0	0.928	1.000	1.000
582	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	132232	2	2	1	3	0	2	0	0	0	0	0.968	1.000	1.000
583	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), LCT(1)	1198130	2	2	2	5	1	1	0	0	0	0	0.994	1.000	1.000
584	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), DHRS2(2)	1804083	3	2	3	6	0	0	0	3	0	0	0.999	1.000	1.000
585	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2)	1190333	2	2	2	4	0	0	0	2	0	0	0.996	1.000	1.000
586	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACSS2(1), IDH1(1), MDH2(1)	964320	3	2	3	6	1	1	0	1	0	0	0.997	1.000	1.000
587	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(2), HSD17B4(1), SIRT1(1)	867807	4	2	4	4	0	0	3	1	0	0	0.937	1.000	1.000
588	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(2), OGDH(1)	684984	3	2	3	5	0	0	0	3	0	0	0.994	1.000	1.000
589	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(2), HDC(1)	442339	3	2	3	8	1	0	1	1	0	0	0.999	1.000	1.000
590	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	BCL10(1), BCL2(1)	861646	2	2	2	4	1	0	0	1	0	0	0.990	1.000	1.000
591	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	WASF1(1), WASL(1)	602723	2	2	2	2	1	0	0	1	0	0	0.955	1.000	1.000
592	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1)	742959	1	1	1	2	0	0	0	1	0	0	0.982	1.000	1.000
593	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	OPRK1(1)	943548	1	1	1	4	1	0	0	0	0	0	0.995	1.000	1.000
594	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HSD17B4(1)	629310	1	1	1	2	0	0	1	0	0	0	0.965	1.000	1.000
595	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1)	785544	1	1	1	5	0	1	0	0	0	0	0.997	1.000	1.000
596	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	UGT1A10(1)	1249774	1	1	1	3	1	0	0	0	0	0	0.995	1.000	1.000
597	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB9A(1)	312573	1	1	1	2	0	1	0	0	0	0	0.983	1.000	1.000
598	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	IDH1(1), MDH2(1)	647342	2	1	2	4	1	1	0	0	0	0	0.988	1.000	1.000
599	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1)	452082	1	1	1	2	1	0	0	0	0	0	0.989	1.000	1.000
600	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	UBE2D3(1)	748436	1	1	1	5	0	1	0	0	0	0	1.000	1.000	1.000
601	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	PDHA2(1)	724252	1	1	1	6	0	0	1	0	0	0	1.000	1.000	1.000
602	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7		405117	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
603	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7		252350	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
604	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3		137449	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
605	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6		388880	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
606	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		121917	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
607	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8		315346	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		36378	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
609	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2		128704	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
610	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		156741	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5		351159	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		109350	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4		273918	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4		490665	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
615	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4		372890	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5		260296	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
