rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(2), CDKN2A(19), E2F1(2), MDM2(2), PIK3CA(21), PIK3R1(5), POLR1A(4), POLR1B(3), POLR1C(5), RAC1(1), RB1(8), TBX2(2), TP53(174), TWIST1(2)	5500423	250	165	171	15	53	53	23	23	95	3	1.34e-14	<1.00e-15	<6.31e-14
2	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(4), DLD(4), DUSP10(3), DUSP4(1), GAB1(1), GCK(1), IL1R1(1), JUN(1), MAP2K4(3), MAP2K5(2), MAP3K1(8), MAP3K10(4), MAP3K11(3), MAP3K12(2), MAP3K13(2), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAP3K5(8), MAP3K7(3), MAP3K9(2), MAPK10(3), MAPK7(1), MAPK8(1), MAPK9(2), MYEF2(2), NFATC3(2), NR2C2(4), PAPPA(6), TP53(174), TRAF6(1), ZAK(4)	13707275	263	163	192	23	66	56	25	27	86	3	9.94e-12	<1.00e-15	<6.31e-14
3	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(2), ATM(22), BRCA1(6), CDKN1A(2), CHEK1(1), CHEK2(3), JUN(1), MAPK8(1), MDM2(2), MRE11A(2), NFKB1(2), RAD50(3), RAD51(3), RBBP8(3), TP53(174), TP73(3)	8026064	230	161	157	10	53	51	22	24	77	3	1.18e-14	<1.00e-15	<6.31e-14
4	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(3), IFNG(1), IFNGR1(1), IKBKB(2), JAK2(2), LIN7A(2), NFKB1(2), RB1(8), TNFRSF1B(1), TP53(174), WT1(4)	5099114	200	161	130	12	52	33	19	18	75	3	8.62e-13	<1.00e-15	<6.31e-14
5	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(22), ATR(5), BRCA1(6), BRCA2(9), CHEK1(1), CHEK2(3), FANCA(5), FANCC(2), FANCD2(4), FANCF(1), FANCG(1), MRE11A(2), RAD17(4), RAD50(3), RAD51(3), TP53(174), TREX1(1)	11882135	246	160	174	14	53	52	29	26	83	3	1.64e-12	<1.00e-15	<6.31e-14
6	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(22), CDC25A(3), CDC25B(2), CDK2(1), CHEK1(1), MYT1(4), RB1(8), TP53(174), WEE1(1)	4826897	216	160	146	6	51	44	21	19	78	3	<1.00e-15	<1.00e-15	<6.31e-14
7	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CCND1(1), CDK2(1), CDKN1A(2), CDKN2A(19), CFL1(1), E2F1(2), E2F2(2), MDM2(2), NXT1(1), PRB1(2), TP53(174)	2257529	208	159	137	5	51	37	18	19	80	3	<1.00e-15	<1.00e-15	<6.31e-14
8	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(13), DAXX(3), HRAS(1), PML(4), RB1(8), SIRT1(5), SP100(7), TNFRSF1B(1), TP53(174)	5160329	216	157	146	6	52	37	22	20	82	3	<1.00e-15	<1.00e-15	<6.31e-14
9	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(22), ATR(5), CHEK1(1), CHEK2(3), TP53(174)	4342671	205	156	135	4	50	37	22	22	71	3	<1.00e-15	<1.00e-15	<6.31e-14
10	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(5), DNAJC3(1), EIF2S1(1), NFKB1(2), TP53(174)	2784224	183	155	113	4	47	32	18	16	67	3	1.11e-15	1.22e-15	6.31e-14
11	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	APAF1(3), BAK1(1), BAX(2), BCL2L1(1), BCL2L11(3), BID(1), BIRC2(1), BIRC3(2), BNIP3L(1), CASP1(5), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CHUK(5), DFFA(1), DFFB(2), FADD(1), FASLG(1), HELLS(2), IKBKB(2), IRF1(1), IRF4(4), IRF5(1), IRF6(1), JUN(1), MAP2K4(3), MAP3K1(8), MAPK10(3), MDM2(2), NFKB1(2), PLEKHG5(4), PRF1(4), RIPK1(2), TNFRSF10B(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(4), TNFSF10(1), TP53(174), TP73(3), TRAF1(2), TRAF2(1), TRAF3(1)	15804413	271	167	201	26	70	56	30	28	84	3	1.04e-11	1.33e-15	6.31e-14
12	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(2), ATM(22), ATR(5), CCNA1(3), CCND1(1), CCNE1(2), CDC25A(3), CDK2(1), CDK6(2), CDKN1A(2), CDKN2A(19), E2F1(2), GSK3B(3), HDAC1(1), RB1(8), TFDP1(1), TGFB2(1), TGFB3(2), TP53(174)	8232799	254	163	183	12	53	51	26	25	96	3	<1.00e-15	1.33e-15	6.31e-14
13	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(4), APAF1(3), ATM(22), BAX(2), BCL2L1(1), BID(1), CASP6(1), CASP7(1), CASP9(1), EIF2S1(1), PRKCA(1), PTK2(1), PXN(3), STAT1(3), TLN1(7), TP53(174)	7511408	226	159	156	13	59	47	24	20	73	3	5.35e-14	1.33e-15	6.31e-14
14	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	APAF1(3), BAK1(1), BAX(2), BCL2L1(1), BID(1), BIRC2(1), BIRC3(2), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), FADD(1), FASLG(1), JUN(1), MAP2K4(3), MAP3K1(8), MAPK10(3), MCL1(1), MDM2(2), NFKB1(2), PARP1(2), PRF1(4), RIPK1(2), TNFRSF1B(1), TNFSF10(1), TP53(174), TRAF1(2), TRAF2(1)	10290800	231	163	161	18	59	43	25	22	79	3	4.96e-12	1.78e-15	7.82e-14
15	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(22), ATR(5), BRCA1(6), CCNB1(1), CDC25A(3), CDC25B(2), CDKN1A(2), CDKN2D(1), CHEK1(1), CHEK2(3), EP300(12), MDM2(2), MYT1(4), PRKDC(14), RPS6KA1(1), TP53(174), WEE1(1), YWHAQ(1)	11842579	255	164	185	17	54	60	27	27	84	3	1.46e-12	2.11e-15	8.45e-14
16	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MAX(1), SP1(1), SP3(2), TP53(174), WT1(4)	1904802	183	154	113	6	48	31	18	18	65	3	1.89e-15	2.22e-15	8.45e-14
17	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(3), ATM(22), BAX(2), CCND1(1), CCNE1(2), CDK2(1), CDKN1A(2), E2F1(2), MDM2(2), RB1(8), TIMP3(2), TP53(174)	5001239	221	161	151	9	51	42	23	21	81	3	4.66e-15	2.33e-15	8.45e-14
18	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(4), EGFR(5), IGF1R(4), POLR2A(3), PPP2CA(1), PRKCA(1), RB1(8), TEP1(2), TERF1(2), TERT(2), TNKS(2), TP53(174), XRCC5(4)	7711695	212	159	141	15	52	41	22	16	78	3	4.08e-12	2.55e-15	8.74e-14
19	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(7), AKT1(4), ATM(22), BAX(2), CDKN1A(2), CPB2(1), CSNK1A1(2), CSNK1D(1), HIC1(1), HIF1A(5), IGFBP3(2), MAPK8(1), MDM2(2), NQO1(1), TP53(174)	5717213	227	161	156	9	53	52	25	22	72	3	<1.00e-15	3.11e-15	9.92e-14
20	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(3), ATM(22), ATR(5), BAI1(6), BAX(2), BID(1), CASP8(6), CASP9(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND1(1), CCNE1(2), CDK2(1), CDK6(2), CDKN1A(2), CDKN2A(19), CHEK1(1), CHEK2(3), DDB2(1), EI24(1), GADD45B(2), GTSE1(2), IGF1(1), IGFBP3(2), MDM2(2), MDM4(1), PERP(2), PMAIP1(1), PPM1D(2), PTEN(7), RCHY1(3), RFWD2(1), RRM2B(1), SERPINB5(2), SESN2(3), SESN3(1), STEAP3(4), THBS1(2), TNFRSF10B(1), TP53(174), TP73(3), TSC2(7)	18030959	308	169	237	21	71	64	31	29	109	4	<1.00e-15	3.22e-15	9.92e-14
21	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(22), CCNA1(3), CCNB1(1), CCND1(1), CCNE1(2), CDC25A(3), CDK2(1), CDKN1A(2), CDKN1C(1), CDKN2A(19), CDKN2C(1), CDKN2D(1), CREB3L1(2), CREB3L4(1), E2F1(2), E2F2(2), E2F3(1), E2F5(1), E2F6(1), GBA2(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), MDM2(2), MNAT1(1), MYT1(4), NACA(7), POLA2(2), POLE(8), POLE2(1), PRIM1(4), RB1(8), RBL1(2), RPA1(3), TFDP1(1), TFDP2(4), TNXB(14), TP53(174), WEE1(1)	21250868	314	165	243	29	73	71	30	35	102	3	2.32e-13	1.61e-13	4.72e-12
22	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(2), ATM(22), BUB1(2), BUB1B(3), CCNA1(3), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(3), CCNE1(2), CDAN1(4), CDC14A(2), CDC14B(1), CDC20(3), CDC25A(3), CDC25B(2), CDC6(5), CDC7(1), CDH1(1), CDK2(1), CDKN1A(2), CDKN2A(19), CHEK1(1), CHEK2(3), DTX4(2), E2F1(2), E2F2(2), E2F3(1), E2F5(1), E2F6(1), EP300(12), ESPL1(8), GSK3B(3), HDAC1(1), HDAC3(3), HDAC4(12), HDAC5(2), HDAC6(3), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), MDM2(2), MPEG1(2), MPL(2), PLK1(2), PRKDC(14), PTPRA(4), RB1(8), RBL1(2), SMAD4(14), TBC1D8(3), TFDP1(1), TP53(174), WEE1(1)	30563516	380	172	303	34	86	92	38	35	126	3	<1.00e-15	3.38e-06	9.47e-05
23	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(4), PIK3CA(21), PIK3R1(5), PLCB1(3), PLCG1(5), PRKCA(1), VAV1(8)	3557761	47	38	39	3	6	21	5	5	10	0	0.00101	0.000132	0.00354
24	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(3), ERBB4(17), NRG2(2), NRG3(8), PRKCA(1), PSEN1(2)	2524886	33	29	33	2	6	10	7	2	8	0	0.00484	0.000412	0.0106
25	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BAK1(1), BAX(2), BTK(1), CAD(11), CASP8(6), CD7(1), CSNK1A1(2), DAXX(3), DEDD(1), DEDD2(1), DFFA(1), EGFR(5), EPHB2(4), FADD(1), FAF1(3), FAIM2(1), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MET(4), NFAT5(4), NFKB1(2), NFKB2(2), NR0B2(1), PTPN13(7), RALBP1(2), RIPK1(2), ROCK1(2), SMPD1(2), TP53(174), TPX2(3), TRAF2(1)	20190050	281	164	211	36	71	63	29	29	86	3	1.81e-08	0.000493	0.0122
26	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	AIFM1(1), AKT1(4), AKT2(1), AKT3(2), APAF1(3), ATM(22), BAX(2), BCL2L1(1), BID(1), BIRC2(1), BIRC3(2), CAPN1(1), CAPN2(1), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CFLAR(2), CHUK(5), CSF2RB(6), DFFA(1), DFFB(2), ENDOG(1), FADD(1), FASLG(1), IKBKB(2), IL1B(3), IL1R1(1), IL1RAP(2), IL3(2), IL3RA(1), IRAK1(2), IRAK3(1), IRAK4(1), NFKB1(2), NFKB2(2), NTRK1(5), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKACA(3), PRKAR1B(2), PRKAR2B(3), RIPK1(2), TNFRSF10A(1), TNFRSF10B(1), TNFSF10(1), TP53(174), TRAF2(1)	23247581	332	170	254	37	78	84	35	36	96	3	2.07e-12	0.000659	0.0156
27	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR3(1), PAK1(2), PDGFRA(4), PIK3CA(21), PIK3R1(5), RAC1(1), WASL(2)	3706822	36	33	28	2	3	14	4	8	7	0	0.00685	0.00108	0.0246
28	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(2), CDK2(1), CUL1(4), E2F1(2), FBXW7(14), RB1(8), TFDP1(1)	2346981	32	26	30	3	2	6	3	4	17	0	0.0946	0.00122	0.0268
29	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(6), FMOD(2), KERA(2), LUM(3)	981573	14	14	14	0	2	6	2	3	1	0	0.0195	0.00162	0.0344
30	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(3), APC(15), AXIN1(2), BTRC(3), CTNNB1(9), DLL1(1), FZD1(4), GSK3B(3), NOTCH1(20), PSEN1(2), WNT1(1)	5943593	63	50	62	6	10	10	12	7	21	3	0.0104	0.00432	0.0888
31	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(7), GABRA2(8), GABRA3(1), GABRA4(3), GABRA5(4), GABRA6(7), PRKCE(2)	2197196	32	27	32	3	7	8	11	2	4	0	0.0105	0.00518	0.103
32	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(3), DLL1(1), FURIN(2), NOTCH1(20), PSEN1(2)	2782582	28	25	28	2	5	2	3	5	11	2	0.0664	0.00688	0.133
33	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNA2(1), CCND1(1), CCNE1(2), CDK2(1), CDKN2A(19), E2F1(2), E2F2(2), PRB1(2)	2466158	33	30	32	5	6	7	3	3	14	0	0.0753	0.0113	0.211
34	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(3), CCNB1(1), CCND1(1), CCNE1(2), CDC25A(3), CDK2(1), CDK6(2), CDKN1A(2), CDKN2A(19), CDKN2C(1), CDKN2D(1), E2F1(2), RB1(8), RBL1(2), TFDP1(1)	4420427	49	40	48	6	4	13	4	4	24	0	0.0287	0.0117	0.212
35	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3E(1), CD80(1), CD86(1), HLA-DRB1(1), ITK(7), LCK(1), PIK3CA(21), PIK3R1(5), PTPN11(2)	3487944	41	37	33	5	5	17	7	5	7	0	0.0302	0.0276	0.486
36	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(1), IFNG(1), IL2RA(1), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15), TGFBR3(3), TOB1(2), TOB2(1)	2842910	30	28	27	4	4	11	3	6	6	0	0.129	0.0303	0.519
37	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(4), HRAS(1), KLK2(1), NTRK1(5), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), SOS1(3)	4293193	46	38	38	5	8	19	5	7	7	0	0.00940	0.0635	1.000
38	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABRA1(7), GABRA2(8), GABRA3(1), GABRA4(3), GABRA5(4), GABRA6(7), GPHN(3), UBQLN1(1)	3356212	38	31	38	4	10	9	11	3	5	0	0.00940	0.0681	1.000
39	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(1), JUN(1), KEAP1(6), MAPK1(1), MAPK14(1), MAPK8(1), NFE2L2(18), PRKCA(1)	2590982	30	27	26	5	5	8	7	7	3	0	0.142	0.0685	1.000
40	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(4), EIF2B5(2), EIF2S1(1), EIF2S3(2), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(4), INPPL1(2), PDK2(1), PIK3CA(21), PIK3R1(5), PPP2CA(1), PTEN(7)	5494188	55	46	47	6	4	21	9	6	14	1	0.00721	0.0707	1.000
41	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(3), CPS1(11), GLS(2), GLUD1(1)	2139811	18	16	18	1	2	8	5	2	1	0	0.0318	0.0888	1.000
42	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(4), AKT2(1), AKT3(2), CDKN1A(2), ELK1(2), HRAS(1), MAP2K1(2), MAP2K2(3), NGFR(2), NTRK1(5), PIK3CA(21), PIK3CD(5), SOS1(3)	4628732	53	44	45	7	13	22	5	9	4	0	0.00423	0.0941	1.000
43	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(4), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(6), EIF4G2(1), EIF4G3(4), MKNK1(1), PDK2(1), PIK3CA(21), PIK3R1(5), PPP2CA(1), PTEN(7), TSC1(10), TSC2(7)	7692411	72	60	64	8	5	26	11	8	21	1	0.00249	0.0994	1.000
44	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), INSR(9), IRS1(6), JUN(1), MAP2K1(2), MAPK8(1), PIK3CA(21), PIK3R1(5), PTPN11(2), RAF1(2), RASA1(9), SOS1(3)	6976484	66	53	58	6	12	24	10	8	12	0	0.000613	0.109	1.000
45	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(5), ACADS(2), ACAT1(3), ECHS1(1), HADHA(2)	1517471	13	12	13	0	2	6	1	0	4	0	0.0680	0.116	1.000
46	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(4), SNAP25(1), STX1A(2)	881127	9	8	8	0	6	1	1	1	0	0	0.0557	0.117	1.000
47	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(5), IFNG(1), IL12B(1)	817967	7	7	7	1	0	4	2	0	1	0	0.356	0.125	1.000
48	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), AKT1(4), CALM3(1), GNAS(16), GNGT1(1), NFKB1(2), NOS3(5), NR3C1(1), PIK3CA(21), PIK3R1(5), SYT1(3)	4995573	60	50	52	9	14	22	7	5	12	0	0.0210	0.126	1.000
49	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(4), AOC3(5), CES1(5)	1669838	14	13	14	2	6	2	1	2	3	0	0.125	0.159	1.000
50	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(15), AXIN1(2), CREBBP(13), CTNNB1(9), EP300(12), FZD1(4), GSK3B(3), HDAC1(1), LDB1(1), PITX2(1), TRRAP(15), WNT1(1)	8831400	77	57	76	8	12	22	13	6	23	1	0.00167	0.176	1.000
51	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(4), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1)	2127906	19	19	19	2	5	7	4	2	1	0	0.0616	0.182	1.000
52	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(2), ANAPC1(5), ANAPC2(2), ANAPC4(2), ANAPC5(3), ANAPC7(1), ATM(22), ATR(5), BUB1(2), BUB1B(3), CCNA1(3), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND1(1), CCNE1(2), CDC14A(2), CDC14B(1), CDC20(3), CDC23(1), CDC25A(3), CDC25B(2), CDC26(1), CDC27(7), CDC6(5), CDC7(1), CDK2(1), CDK6(2), CDKN1A(2), CDKN1C(1), CDKN2A(19), CDKN2C(1), CDKN2D(1), CHEK1(1), CHEK2(3), CREBBP(13), CUL1(4), DBF4(3), E2F1(2), E2F2(2), E2F3(1), EP300(12), ESPL1(8), FZR1(4), GADD45B(2), GSK3B(3), HDAC1(1), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), MDM2(2), PKMYT1(2), PLK1(2), PRKDC(14), RB1(8), RBL1(2), RBL2(4), SMAD2(2), SMAD3(3), SMAD4(14), SMC1B(4), TFDP1(1), TGFB2(1), TGFB3(2), TP53(174), WEE1(1), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1)	37645484	423	172	351	42	78	112	43	44	142	4	1.47e-14	0.215	1.000
53	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(3), ESR1(6), GREB1(9), HSPB2(1), MTA1(3), MTA3(2), PDZK1(1), TUBA8(5)	3143384	30	26	30	3	8	8	5	5	4	0	0.00955	0.226	1.000
54	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(3)	1046227	7	7	7	0	2	1	2	0	2	0	0.125	0.238	1.000
55	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1), SRP54(5), SRP68(2), SRP72(2), SRPR(2)	2062185	13	13	13	1	1	4	3	3	2	0	0.205	0.245	1.000
56	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(3), CCNE1(2), CDK2(1), CUL1(4), E2F1(2), RB1(8), TFDP1(1)	2420467	21	20	21	4	1	5	2	2	11	0	0.404	0.246	1.000
57	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(2), CDK2(1), CUL1(4), E2F1(2), NEDD8(2), RB1(8), TFDP1(1), UBE2M(1)	2384711	21	19	21	4	0	6	2	2	11	0	0.428	0.252	1.000
58	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(13), EP300(12), LPL(2), NCOA1(7), NCOA2(6), PPARG(2)	4973922	42	34	42	4	7	15	3	3	14	0	0.0122	0.263	1.000
59	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(22), CDC25A(3), CDC25B(2), CHEK1(1), MYT1(4), WEE1(1)	3766467	33	28	33	4	5	15	4	3	6	0	0.0353	0.281	1.000
60	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(8)	1025905	8	7	8	0	0	3	2	3	0	0	0.137	0.283	1.000
61	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), JUN(1), KLK2(1), MAP2K1(2), MAPK8(1), NGFR(2), PIK3CA(21), PIK3R1(5), PLCG1(5), RAF1(2), SOS1(3)	5263606	48	40	40	7	8	20	6	7	7	0	0.0303	0.284	1.000
62	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(6), CFL1(1), CFLAR(2)	1010390	9	7	9	1	0	4	1	2	2	0	0.372	0.287	1.000
63	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(8), BCAR1(6), CSK(2), CTNNA1(7), CTNNA2(8), CTNNB1(9), PTK2(1), PXN(3), VCL(8)	5416110	53	46	51	7	17	16	6	6	8	0	0.00242	0.298	1.000
64	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(3), JAK2(2), JAK3(6), PIAS1(7), PIAS3(1), PTPRU(7), REG1A(1), SOAT1(1)	3863611	28	25	24	2	13	3	4	3	5	0	0.00762	0.300	1.000
65	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), HGD(2)	616902	4	4	4	0	1	1	0	0	2	0	0.469	0.300	1.000
66	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(8), CASP1(5), CASP8(6), CASP9(1), JUN(1), PRF1(4)	3494274	28	24	28	4	3	12	8	1	4	0	0.121	0.317	1.000
67	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(4)	557991	4	4	4	0	0	2	1	1	0	0	0.340	0.322	1.000
68	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(2)	475782	4	4	4	1	0	2	1	1	0	0	0.616	0.326	1.000
69	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS2(2), CPO(4), FECH(1), GATA1(1), HBA2(1), HBB(2), HMBS(1), UROD(1), UROS(1)	2228973	15	15	15	2	3	6	4	0	2	0	0.133	0.355	1.000
70	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(4), BCAR1(6), ILK(2), ITGB1(1), MAPK1(1), PDK2(1), PIK3CA(21), PIK3R1(5), PTEN(7), PTK2(1), SOS1(3)	5351483	52	46	44	9	5	20	7	9	10	1	0.0912	0.357	1.000
71	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(13), EP300(12), FYN(1), IL2RG(3), IL7R(3), JAK1(3), JAK3(6), LCK(1), PIK3CA(21), PIK3R1(5), PTK2B(4), STAT5A(3), STAT5B(2)	7654155	77	62	69	10	11	27	8	10	21	0	0.00640	0.366	1.000
72	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(4), BAIAP2(2), CASP1(5), CASP7(1), CASP8(6), GAPDH(2), INSR(9), ITCH(3), MAGI1(4), MAGI2(8), RERE(7), WWP1(6), WWP2(3)	6362409	60	47	60	6	12	18	9	10	11	0	0.00241	0.383	1.000
73	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOB(2), ALDOC(4)	1053617	8	8	8	2	2	3	2	1	0	0	0.501	0.394	1.000
74	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS2(2), CPOX(1), FECH(1), HMBS(1), PPOX(4), UROD(1), UROS(1)	2036423	12	12	12	0	3	3	1	1	4	0	0.0382	0.408	1.000
75	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), TGDS(2), UGDH(3), UXS1(1)	1102634	7	7	7	1	1	2	1	1	2	0	0.524	0.409	1.000
76	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), IGF1(1), IGF1R(4), IRS1(6), JUN(1), MAP2K1(2), MAPK8(1), PIK3CA(21), PIK3R1(5), PTPN11(2), RAF1(2), RASA1(9), SOS1(3)	6814758	62	47	54	9	10	23	10	7	12	0	0.0224	0.425	1.000
77	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(4), IL2RG(3), IL4R(3), IRS1(6), JAK1(3), JAK3(6), STAT6(3)	4092468	28	24	28	2	5	4	6	7	6	0	0.0309	0.442	1.000
78	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(14), GNA12(1), PRKAG1(1), PRKAR2B(3)	2698874	19	17	19	2	1	11	1	4	2	0	0.113	0.449	1.000
79	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1)	2130519	18	17	18	3	7	4	2	1	4	0	0.168	0.483	1.000
80	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1)	2130519	18	17	18	3	7	4	2	1	4	0	0.168	0.483	1.000
81	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(1), EHHADH(1), HADHA(2), SDS(1)	1349243	8	8	8	1	3	5	0	0	0	0	0.208	0.484	1.000
82	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	195128	1	1	1	0	1	0	0	0	0	0	0.721	0.490	1.000
83	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(1), COPS5(3), EP300(12), HIF1A(5), JUN(1), NOS3(5), P4HB(2)	4694880	29	28	29	2	2	16	3	2	6	0	0.0256	0.498	1.000
84	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(2), NFYC(1), RB1(8), SP1(1), SP3(2)	1793973	15	13	15	6	0	4	0	2	9	0	0.962	0.502	1.000
85	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	445864	2	2	2	0	1	0	1	0	0	0	0.517	0.507	1.000
86	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(1), CCR3(2), HLA-DRB1(1), IL3(2)	836730	6	5	6	1	2	1	0	0	3	0	0.482	0.517	1.000
87	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), JAK1(3), PTPRU(7), REG1A(1), STAT1(3), STAT2(4), TYK2(3)	3478016	23	20	23	1	8	6	2	3	4	0	0.00470	0.524	1.000
88	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(3), CSF1(1), IL6(1), LDLR(3), LPL(2)	1449176	10	9	10	1	1	3	1	0	5	0	0.205	0.524	1.000
89	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(16), GNGT1(1), PRKACA(3)	1804529	25	25	25	5	10	6	2	2	5	0	0.271	0.525	1.000
90	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(3), ACAT2(1), BDH1(1), BDH2(4), HMGCS2(2), OXCT2(1)	1974087	12	11	12	1	0	7	1	1	3	0	0.228	0.536	1.000
91	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), ADRB2(1), CFTR(8), GNAS(16), PRKAR1B(2), PRKAR2B(3), SLC9A3R1(3)	3580931	38	35	38	7	11	11	2	6	8	0	0.198	0.553	1.000
92	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(2), HLA-DRB1(1), IL1B(3), IL5RA(4), IL6(1)	1455578	11	10	11	2	2	5	0	0	4	0	0.313	0.555	1.000
93	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(7), ABCB11(6), ABCB4(4), ABCC1(3), ABCC3(2), GSTP1(1)	4014069	23	22	21	0	2	9	6	1	5	0	0.00117	0.563	1.000
94	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(4), FUT1(1), FUT9(4)	1675929	9	9	9	0	5	3	0	1	0	0	0.0392	0.569	1.000
95	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(1), IFNGR1(1), JAK1(3), JAK2(2), PTPRU(7), REG1A(1), STAT1(3)	3156241	18	17	18	1	6	5	1	1	5	0	0.0211	0.577	1.000
96	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PDXP(3), PNPO(2), PSAT1(3)	1312884	12	12	12	4	2	6	2	1	1	0	0.600	0.603	1.000
97	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), TGDS(2), UGDH(3), UXS1(1)	1384425	7	7	7	1	1	2	1	1	2	0	0.527	0.618	1.000
98	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(4), CHRNB1(6), CHRNG(3), MUSK(2), PIK3CA(21), PIK3R1(5), PTK2(1), PTK2B(4), RAPSN(2), TERT(2)	4605445	50	38	42	9	11	18	4	5	12	0	0.0388	0.629	1.000
99	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(4), ACAT1(3), ACAT2(1), ECHS1(1), EHHADH(1), HADHA(2), SDS(1)	2325113	13	12	13	1	1	8	0	0	4	0	0.193	0.649	1.000
100	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(3), CDC25B(2), CDKN1A(2), CHEK1(1), NEK1(3), WEE1(1)	2118074	12	12	12	2	3	6	0	1	2	0	0.330	0.649	1.000
101	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(3)	812690	4	4	4	1	0	2	1	0	1	0	0.683	0.651	1.000
102	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), IDH2(4), MDH1(2), OGDH(2), SDHA(4)	2609673	13	13	13	0	4	5	1	1	2	0	0.0127	0.651	1.000
103	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(13), EP300(12), ESR1(6), MAPK1(1), PELP1(3)	3966827	35	30	35	6	7	11	5	2	10	0	0.110	0.653	1.000
104	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(2), GBA(2), SHMT1(2), SHMT2(2)	1595795	8	8	8	1	2	2	1	1	2	0	0.303	0.654	1.000
105	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1)	310721	1	1	1	0	0	1	0	0	0	0	0.743	0.660	1.000
106	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(2), F2(4), F2R(4), F5(4), F7(1), FGA(4), FGB(3), FGG(1), PROC(1), PROS1(5), TFPI(2)	4498404	31	27	30	4	5	9	6	4	7	0	0.0977	0.661	1.000
107	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), FHL5(2), FSHR(6), GNAS(16), XPO1(4)	2613014	33	29	32	7	10	9	3	5	6	0	0.387	0.662	1.000
108	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF1(1), EIF2B1(4), EIF2B2(1), EIF2B4(1), EIF2B5(2), EIF2S1(1), EIF2S3(2), ELAVL1(3), FLT1(7), FLT4(5), HIF1A(5), HRAS(1), KDR(5), NOS3(5), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), PTK2(1), PXN(3)	9452084	79	57	70	9	13	36	6	12	12	0	0.000655	0.663	1.000
109	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), ECHS1(1), EHHADH(1), HADHA(2), SDS(1)	3296820	23	21	23	3	8	8	2	1	4	0	0.0564	0.678	1.000
110	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(2), ACO2(1), ACSS1(2), ACSS2(8), IDH1(1), IDH2(4), MDH1(2), MDH2(2)	3642127	24	19	24	1	3	16	0	3	2	0	0.00435	0.682	1.000
111	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	412019	1	1	1	0	0	0	0	0	1	0	0.803	0.684	1.000
112	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), ACO2(1), IDH1(1), IDH2(4), MDH1(2), MDH2(2)	2453598	12	12	12	0	3	7	0	1	1	0	0.0289	0.684	1.000
113	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(4), CCND1(1), CCNE1(2), CDK2(1), CDK6(2), CDKN1A(2), E2F1(2), HRAS(1), MAPK1(1), NFKB1(2), PAK1(2), PIK3CA(21), PIK3R1(5), RAC1(1), RAF1(2), RB1(8), TFDP1(1)	5604184	58	47	50	10	3	21	6	9	19	0	0.0631	0.691	1.000
114	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(4), ECHS1(1), HADH(1), HADHA(2), HSD17B4(4), PPT1(1), PPT2(1)	2357126	14	13	14	2	2	7	0	1	4	0	0.312	0.691	1.000
115	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), ACO2(1), DLD(4), IDH1(1), IDH2(4), IDH3A(1), IDH3B(2), IDH3G(2), MDH1(2), MDH2(2), PC(1), PCK1(2), SDHA(4), SUCLG1(2), SUCLG2(1)	5674098	31	28	30	1	5	15	3	1	7	0	0.00129	0.695	1.000
116	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(3), SNCAIP(4), UBE2F(1), UBE2G2(1), UBE2L6(1)	1699678	12	11	12	3	3	4	1	1	3	0	0.433	0.700	1.000
117	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(1), MUT(3)	1333526	7	7	7	0	1	3	1	1	1	0	0.132	0.713	1.000
118	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(2), IDI1(1), SQLE(1)	921844	6	6	6	2	0	5	1	0	0	0	0.647	0.716	1.000
119	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(3), ACAT2(1)	942886	4	4	4	0	0	2	0	0	2	0	0.617	0.724	1.000
120	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC1(2), APOBEC2(2), APOBEC3F(1), APOBEC3G(2), APOBEC4(2)	2013603	14	13	14	3	4	8	1	1	0	0	0.293	0.729	1.000
121	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(6), CSF1R(9), EGF(4), EGFR(5), MET(4), PDGFRA(4), PRKCA(1), SH3GLB1(2), SH3GLB2(2), SH3KBP1(5)	5320627	42	35	42	6	6	20	2	6	8	0	0.0442	0.736	1.000
122	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(5), DPYS(4), ENPP1(5), ENPP3(4), PANK1(3), PANK2(4), PANK3(4), PANK4(4)	3853861	34	33	34	8	4	17	3	4	6	0	0.255	0.741	1.000
123	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(4), AKT2(1), AKT3(2), BTK(1), CDKN2A(19), DAPP1(1), GSK3A(2), GSK3B(3), IARS(4), INPP5D(4), PIK3CA(21), PPP1R13B(4), PTEN(7), RPS6KA1(1), RPS6KA2(1), SOS1(3), SOS2(1), TEC(1), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1)	9823471	87	67	78	12	11	33	11	10	21	1	0.00427	0.744	1.000
124	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(15), CDH1(1), CREBBP(13), EP300(12), MAP2K1(2), MAP3K7(3), SKIL(2), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15)	6789133	68	55	63	12	10	20	9	6	23	0	0.147	0.755	1.000
125	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(5), ACADS(2), ACADVL(2), ACSL1(2), ACSL3(3), ACSL4(1), CPT1A(2), CPT2(1), EHHADH(1), HADHA(2), SCP2(1)	4590338	22	20	22	0	4	10	2	1	5	0	0.00218	0.761	1.000
126	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(4), CASP9(1), CHUK(5), GH1(1), GHR(2), NFKB1(2), PIK3CA(21), PIK3R1(5), PPP2CA(1)	3883701	42	35	34	9	3	18	8	4	9	0	0.257	0.776	1.000
127	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), JAK1(3), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), PDGFA(2), PDGFRA(4), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RASA1(9), SOS1(3), STAT1(3), STAT3(2), STAT5A(3)	9614440	83	60	75	10	15	31	12	9	16	0	0.00154	0.782	1.000
128	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), SHMT1(2), SHMT2(2)	1212733	5	5	5	1	1	2	1	0	1	0	0.521	0.784	1.000
129	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(2), ACO2(1), CLYBL(1), DLD(4), IDH1(1), IDH2(4), IDH3A(1), IDH3B(2), IDH3G(2), MDH1(2), MDH2(2), OGDH(2), OGDHL(6), PC(1), PCK1(2), PCK2(2), SDHA(4), SDHD(2), SUCLG1(2), SUCLG2(1)	8196688	46	37	45	1	9	20	5	3	9	0	1.41e-05	0.787	1.000
130	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(3), ACAT2(1), ACYP1(1), ECHS1(1), EHHADH(1), GCDH(1), HADHA(2), SDS(1)	2178288	11	10	11	1	1	8	0	0	2	0	0.197	0.798	1.000
131	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(4), EIF2B5(2), EIF2S1(1), EIF2S3(2), GSK3B(3), PPP1CA(1)	3132538	14	13	14	1	2	6	2	0	3	1	0.0728	0.808	1.000
132	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(5), PRKCA(1), PTK2B(4)	1797444	10	10	10	2	2	5	0	0	3	0	0.342	0.814	1.000
133	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(2), IDI1(1), IDI2(1), SQLE(1)	1216703	7	7	7	2	1	5	1	0	0	0	0.555	0.815	1.000
134	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	CSAD(2), GAD1(3), GAD2(2)	1618379	7	7	7	1	1	4	0	0	2	0	0.408	0.815	1.000
135	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLUD1(1), GLUD2(4)	1225159	7	6	7	2	1	4	1	0	1	0	0.555	0.826	1.000
136	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(4), ACOX3(1), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3)	2941902	17	16	17	2	6	7	0	0	4	0	0.0619	0.829	1.000
137	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(1), GRHPR(2), HAO1(1), HAO2(1), MDH1(2), MDH2(2), MTHFD1(2), MTHFD1L(4), MTHFD2(2)	3490731	19	17	19	2	3	9	5	1	1	0	0.0607	0.832	1.000
138	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(3), MST1R(7)	1780726	11	8	11	1	1	5	0	2	3	0	0.182	0.833	1.000
139	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(3), IL4R(3), JAK1(3), JAK2(2), TYK2(3)	2906993	15	14	15	2	2	2	5	4	2	0	0.216	0.834	1.000
140	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(3), IL4R(3), JAK1(3), JAK2(2), TYK2(3)	2906993	15	14	15	2	2	2	5	4	2	0	0.216	0.834	1.000
141	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT2(2), B3GNT5(1), FUT1(1), FUT3(2), ST3GAL3(1), ST3GAL4(1)	1943274	8	8	8	0	2	3	0	3	0	0	0.0962	0.835	1.000
142	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), JAK1(3), STAT1(3), STAT2(4), TYK2(3)	3035561	15	14	15	1	4	5	2	3	1	0	0.0615	0.846	1.000
143	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(1), AFMID(1), GRHPR(2), HAO1(1), HAO2(1), MDH1(2), MDH2(2), MTHFD1(2), MTHFD1L(4), MTHFD2(2)	3668877	20	18	20	2	4	9	5	1	1	0	0.0447	0.859	1.000
144	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(4), APC(15), AXIN1(2), CCND1(1), CD14(1), CTNNB1(9), FZD1(4), GJA1(1), GNAI1(1), GSK3B(3), IRAK1(2), NFKB1(2), PIK3CA(21), PIK3R1(5), PPP2CA(1), TLR4(6), TOLLIP(1), WNT1(1)	8234266	80	60	71	12	7	25	19	7	21	1	0.0143	0.865	1.000
145	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1), ST3GAL5(1)	1481459	7	7	7	1	1	2	2	2	0	0	0.367	0.865	1.000
146	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(3), CDC25B(2), CSK(2), PRKCA(1), PTPRA(4)	2558073	13	13	13	2	3	8	0	0	2	0	0.138	0.876	1.000
147	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), DLAT(1), DLD(4), IDH2(4), IDH3A(1), IDH3B(2), IDH3G(2), MDH1(2), MDH2(2), OGDH(2), PC(1), PDHA2(5), PDHX(1), PDK2(1), PDK3(2), PDK4(1), SDHA(4), SDHD(2), SUCLG1(2), SUCLG2(1)	7832029	41	39	40	4	6	16	7	1	11	0	0.00918	0.879	1.000
148	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(2), FARSB(1), PAH(4), TAT(2), YARS(1), YARS2(2)	2404317	12	12	12	3	1	3	3	1	4	0	0.484	0.879	1.000
149	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), TAT(2), TYR(3)	1270875	7	7	7	2	3	2	1	0	1	0	0.527	0.883	1.000
150	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(14), MAP2(11), PPP1CA(1), PPP2CA(1), PRKAG1(1), PRKAR2B(3), PRKCE(2)	4782075	33	28	33	5	4	10	5	8	6	0	0.136	0.889	1.000
151	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(2)	718746	2	2	2	0	0	1	0	0	1	0	0.500	0.889	1.000
152	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HSD17B4(4), NTAN1(2), SIRT1(5), SIRT5(1), SIRT7(1)	3274960	21	18	21	4	5	11	2	0	3	0	0.236	0.902	1.000
153	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD80(1), HLA-DRB1(1), IL10(2)	1079094	5	5	5	2	1	2	1	0	1	0	0.761	0.904	1.000
154	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAK1(1), BAX(2), BCL10(1), BCL2L1(1), BCL2L11(3), BID(1), CASP9(1), CES1(5)	3071027	18	17	18	4	6	5	3	0	4	0	0.298	0.906	1.000
155	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(4), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G1(6), EIF4G2(1), EIF4G3(4), GHR(2), IRS1(6), MAPK1(1), MAPK14(1), MKNK1(1), PABPC1(2), PDK2(1), PIK3CA(21), PIK3R1(5), PRKCA(1), PTEN(7)	7749922	67	53	59	11	5	24	10	6	21	1	0.0541	0.910	1.000
156	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(4), HLA-A(1), ITGB1(1), KLRC3(1), KLRC4(1), KLRD1(2), MAP2K1(2), PAK1(2), PIK3CA(21), PIK3R1(5), PTK2B(4), RAC1(1), SYK(2), VAV1(8)	5223603	55	41	47	10	6	20	4	10	15	0	0.101	0.913	1.000
157	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), THTPA(1)	1739953	9	6	8	2	0	4	1	0	4	0	0.556	0.917	1.000
158	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), HLA-DRB1(1)	640755	2	2	2	2	0	1	0	0	1	0	0.970	0.923	1.000
159	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(5), GNAS(16), GNGT1(1), PRKAR1B(2), PRKAR2B(3), PRKCA(1)	2672013	28	27	28	7	12	6	2	1	6	1	0.334	0.923	1.000
160	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(2), C1R(1), C1S(1), C2(2), C3(9), C5(2), C6(6), C7(4), C8A(5), C9(2), MASP1(4), MBL2(4)	5944043	42	36	42	7	7	18	2	7	8	0	0.0684	0.924	1.000
161	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(1), HK2(3), HK3(2), IMPA1(1), PGM1(1), TGDS(2)	2859277	11	11	11	1	3	5	0	0	3	0	0.132	0.924	1.000
162	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(4), BCL2L1(1), CASP9(1), CHUK(5), ELK1(2), H2AFX(1), HRAS(1), MAP2K1(2), NFKB1(2), PIK3CA(21), PIK3R1(5), RAC1(1), RAF1(2), RALA(1), RALBP1(2), RHOA(3)	5453038	54	39	46	10	7	22	9	6	10	0	0.0611	0.925	1.000
163	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), FYN(1), HLA-DRB1(1), LCK(1), PTPRC(9), ZAP70(3)	2511337	16	14	16	4	3	9	2	0	2	0	0.339	0.928	1.000
164	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(2), C1R(1), C1S(1), C2(2), C3(9), C5(2), C6(6), C7(4), C8A(5), C9(2)	4876386	34	30	34	6	6	14	2	6	6	0	0.147	0.933	1.000
165	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(9), C5(2), C6(6), C7(4), C8A(5), C9(2)	3485087	28	25	28	6	4	12	2	5	5	0	0.327	0.935	1.000
166	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(1), JAK1(3), JAK2(2), JAK3(6), PIAS3(1), PTPRU(7), REG1A(1), STAT3(2)	4245760	24	23	24	4	7	5	3	3	6	0	0.0943	0.937	1.000
167	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(2), C1R(1), C1S(1), C2(2), C3(9), C5(2), C6(6), C7(4), C8A(5), C8B(3), C9(2), MASP1(4)	5775304	41	34	41	7	8	15	3	7	8	0	0.0829	0.941	1.000
168	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(5), AKT1(4), BAX(2), BCL2L1(1), CSF2RB(6), IGF1(1), IGF1R(4), IL3(2), IL3RA(1), KIT(7), KITLG(2), PIK3CA(21), PIK3R1(5), PRKAR1B(2), PRKAR2B(3)	6035083	66	51	58	14	9	23	12	9	13	0	0.0932	0.942	1.000
169	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), ADRB2(1), GNAS(16), PLCE1(10), PRKAR1B(2), PRKAR2B(3), RAP2B(1)	4033559	38	34	38	9	12	12	3	4	7	0	0.284	0.942	1.000
170	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(4), B3GNT2(1), B3GNT5(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT3(2), FUT4(1), FUT5(1), FUT6(2), FUT7(1), FUT9(4), ST3GAL6(1)	4317984	26	23	26	4	9	9	4	3	1	0	0.0578	0.943	1.000
171	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(1), JAK1(3), JAK2(2), STAT1(3)	2255006	10	9	10	2	2	4	1	1	2	0	0.413	0.944	1.000
172	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(6), ABCG2(6), BCHE(9), CES1(5), CES2(1), CYP3A5(2), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2)	6256205	42	35	42	7	9	13	5	3	12	0	0.0458	0.944	1.000
173	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(5), ACADS(2), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADHA(2), L2HGDH(3), PDHA2(5), SDS(1)	7031960	48	39	48	6	11	19	4	5	9	0	0.0100	0.944	1.000
174	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(4), CREB5(2), MAPK1(1), RAF1(2), SNX13(6), TERF2IP(1)	3193499	16	15	16	3	1	8	1	5	1	0	0.324	0.945	1.000
175	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS3(2), DHRSX(1), HSD3B7(2), PON1(1), PON2(2), PON3(4), RDH13(1)	2430675	14	12	14	4	2	1	4	3	4	0	0.612	0.946	1.000
176	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5R1(1), CFL1(1), CHN1(1), LIMK1(1), MAP3K1(8), MYLK(6), PAK1(2), PDGFRA(4), PIK3CA(21), PIK3R1(5), PLD1(4), PPP1R12B(1), RAC1(1), RALBP1(2), TRIO(4), VAV1(8), WASF1(3)	9558555	74	60	65	12	10	25	12	9	18	0	0.0219	0.950	1.000
177	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(2), FLT3(9), IGF1(1), IL3(2), IL6(1), KITLG(2), TGFB2(1), TGFB3(2)	2330556	20	17	20	5	2	7	3	1	7	0	0.357	0.951	1.000
178	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(1), HK2(3), HK3(2), IMPA1(1), ISYNA1(1), PGM1(1), TGDS(2)	3250139	12	12	12	1	3	5	0	1	3	0	0.106	0.952	1.000
179	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(2), NR3C1(1), PPARG(2), RETN(1)	1561641	7	7	7	2	3	0	0	0	4	0	0.657	0.954	1.000
180	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(1), GLS(2), GLUD1(1), OAT(3)	1616974	11	11	11	4	3	3	3	0	2	0	0.598	0.954	1.000
181	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(4), XDH(9)	2230932	14	14	14	4	1	5	5	1	2	0	0.489	0.958	1.000
182	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT3(2), FUT5(1), FUT6(2), ST3GAL3(1)	1399674	7	7	7	2	3	3	0	1	0	0	0.442	0.958	1.000
183	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(2), CD3E(1), CD58(1), CSF3(2), IL3(2), IL6(1), KITLG(2)	1727349	12	10	12	4	2	5	1	1	3	0	0.625	0.961	1.000
184	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(2), CASP8(6), FADD(1), RIPK1(2), TNFRSF1B(1), TRAF2(1)	2290847	13	11	13	3	3	3	2	2	3	0	0.399	0.961	1.000
185	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(13), DFFA(1), DFFB(2), GZMA(1), HMGB2(1), PRF1(4), SET(3)	2890230	26	24	26	7	7	7	2	2	8	0	0.457	0.965	1.000
186	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(5), CREBBP(13), EP300(12), IKBKB(2), IL1B(3), MAP3K7(3), MAPK11(1), MAPK14(1), NFKB1(2), NR3C1(1), TGFBR1(2), TGFBR2(15), TLR2(5)	7999458	65	51	61	11	11	18	10	5	21	0	0.0953	0.966	1.000
187	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CDC25A(3), CDC25B(2), MNAT1(1), XPO1(4)	2377248	11	9	10	3	2	4	0	2	3	0	0.691	0.966	1.000
188	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), PAPSS2(3), SCLY(2), SEPHS1(3)	3449819	17	15	17	3	5	4	3	2	3	0	0.157	0.966	1.000
189	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(4), EGFR(5), ELK1(2), FOS(1), HRAS(1), JAK1(3), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RASA1(9), SOS1(3), STAT1(3), STAT3(2), STAT5A(3)	10288864	86	59	78	12	13	37	11	9	16	0	0.00442	0.967	1.000
190	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM3(1), CDKN1A(2), GNAQ(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), SP1(1), SP3(2), SYT1(3)	5487856	38	33	38	7	10	14	2	5	7	0	0.0906	0.968	1.000
191	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	606620	1	1	1	0	0	1	0	0	0	0	0.721	0.968	1.000
192	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(2), NDUFA1(1), SDHA(4), SDHD(2)	1773501	11	11	11	4	1	5	2	0	3	0	0.754	0.969	1.000
193	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB1A(1), RAB27A(2), RAB4A(1), RAB5A(1)	1164903	6	6	6	3	2	3	0	0	1	0	0.800	0.973	1.000
194	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(2), CYP11B2(4), CYP17A1(1), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3)	1896878	14	11	14	4	3	8	0	1	2	0	0.402	0.973	1.000
195	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(2), FOS(1), FYN(1), JUN(1), MAPK14(1), THBS1(2)	1986112	8	8	8	2	1	3	2	0	2	0	0.649	0.973	1.000
196	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1), CD3E(1)	866172	3	3	3	2	1	2	0	0	0	0	0.820	0.973	1.000
197	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), GBA(2), LPO(3), MPO(3), PRDX6(3), TPO(8)	2329253	21	20	21	6	6	4	2	3	6	0	0.398	0.974	1.000
198	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(3), HDC(2), TH(3), TPH1(2)	1655011	11	9	11	3	4	5	0	2	0	0	0.371	0.974	1.000
199	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRA2A(3), ADRA2C(2), ADRB1(1), ADRB2(1), CHRM1(2), CHRM2(8), CHRM3(5), CHRM4(2), CHRM5(1), DRD1(3), DRD2(4), DRD3(2), DRD4(1), HRH1(2), HRH2(3), HTR1A(1), HTR1B(1), HTR1D(4), HTR1E(5), HTR1F(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3)	6897069	74	58	73	17	20	25	10	10	9	0	0.0119	0.975	1.000
200	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(4), MMP2(3), MMP9(3), RECK(4), TIMP3(2), TIMP4(2)	2133835	19	18	19	5	7	7	0	2	3	0	0.304	0.977	1.000
201	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1A(1), BMPR1B(4), BMPR2(3)	1666481	9	9	9	3	0	4	4	0	1	0	0.706	0.977	1.000
202	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), COQ5(2), NDUFA13(1)	1178758	4	4	4	2	1	2	1	0	0	0	0.766	0.977	1.000
203	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ATP6V0C(1), EPX(2), LPO(3), MPO(3), PRDX1(2), PRDX2(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(8)	3283440	27	26	27	7	7	7	4	3	6	0	0.282	0.978	1.000
204	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(3), RANBP2(6), RANGAP1(1)	2355983	10	7	10	2	0	6	3	0	1	0	0.572	0.979	1.000
205	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(3), HMOX1(1), IL10(2), IL10RA(3), IL10RB(1), IL6(1), JAK1(3), STAT1(3), STAT3(2), STAT5A(3)	3357001	22	16	21	4	4	8	2	2	6	0	0.112	0.980	1.000
206	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), MIOX(2), UGDH(3)	2301132	16	14	16	4	6	6	0	1	3	0	0.405	0.981	1.000
207	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(5), AASS(3), KARS(2)	1892480	11	11	11	4	1	6	1	1	2	0	0.793	0.981	1.000
208	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(1), CKM(1), FBL(2), GPT(4), MAPK14(1), NCL(5)	2510653	14	13	14	4	6	2	0	1	5	0	0.543	0.983	1.000
209	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(3), BAK1(1), BAX(2), BCL2L1(1), BID(1), BIK(1), BIRC2(1), BIRC3(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), DFFA(1), DFFB(2), ENDOG(1)	3742336	25	20	25	6	6	8	3	1	7	0	0.376	0.984	1.000
210	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADL(5), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), DPYD(5), DPYS(4), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADHA(2), SDS(1)	7903442	52	45	52	9	16	19	5	3	9	0	0.0251	0.987	1.000
211	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(3), NR0B2(1), NR1H4(2)	1487957	7	7	7	3	1	3	1	0	2	0	0.726	0.987	1.000
212	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(4), FYN(1), LRP8(3), RELN(17)	3792313	26	24	24	6	5	13	2	3	3	0	0.309	0.987	1.000
213	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(4), HRAS(1), IGF1R(4), IRS1(6), MAP2K1(2), MAPK1(1), PIK3CA(21), PIK3R1(5), RAF1(2), SOS1(3)	5182218	49	38	41	10	7	18	8	7	9	0	0.155	0.987	1.000
214	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), FOS(1), HRAS(1), JAK2(2), JUN(1), MAP2K1(2), MPL(2), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RASA1(9), SOS1(3), STAT1(3), STAT3(2), STAT5A(3), STAT5B(2), THPO(2)	8233552	68	49	60	10	12	29	6	8	13	0	0.0151	0.987	1.000
215	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(3), AGT(1), AGTR2(2), KNG1(2), NOS3(5), REN(2)	2712517	15	14	15	4	1	8	2	0	4	0	0.375	0.988	1.000
216	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1), GNAQ(1), ITPKB(6)	1545526	8	7	8	7	1	4	0	0	3	0	0.966	0.988	1.000
217	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(4), GLI2(5), GLI3(9), GSK3B(3), PRKAR1B(2), PRKAR2B(3), SMO(4), SUFU(2)	4490658	36	29	36	9	5	12	5	4	10	0	0.333	0.990	1.000
218	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(1), F2(4), F2R(4), FGA(4), FGB(3), FGG(1), PLAT(1), PLG(3), SERPINB2(2)	3679760	24	20	23	5	4	7	3	1	9	0	0.404	0.990	1.000
219	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(5), AKT1(4), CAMK2A(3), CAMK2B(2), GNAS(16), HRAS(1), MAPK1(1), MAPK14(1), PIK3CA(21), PIK3R1(5), PRKAR1B(2), PRKAR2B(3), PRKCA(1), RAC1(1), RPS6KA1(1), RPS6KA5(4), SOS1(3)	8035746	74	57	66	13	18	26	7	11	12	0	0.0325	0.990	1.000
220	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), CALM3(1), ELK1(2), FOS(1), HRAS(1), JUN(1), LYN(2), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK8(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PAK2(1), PIK3CA(21), PIK3R1(5), PLA2G4A(1), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), RAF1(2), SOS1(3), SYK(2), SYT1(3), VAV1(8)	11666378	97	64	89	14	20	34	12	11	20	0	0.00220	0.991	1.000
221	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(2), HDAC9(11), MEF2A(1), MEF2C(2), MEF2D(3), MYOD1(1)	2341377	21	20	21	9	5	8	2	0	6	0	0.712	0.991	1.000
222	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(3), HSD17B1(1), HSD17B4(4), HSD3B1(2), HSD3B2(3)	2189461	14	9	14	3	2	7	2	0	3	0	0.438	0.991	1.000
223	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), BIRC2(1), BIRC3(2), CASP1(5), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), DFFA(1), DFFB(2), LMNA(2), LMNB1(1), LMNB2(5), PRF1(4)	5263175	37	31	37	7	8	13	5	2	9	0	0.140	0.992	1.000
224	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(4), AKT2(1), AKT3(2), BCL2L1(1), CDK2(1), CDKN2A(19), CREB5(2), ERBB4(17), F2RL2(1), GAB1(1), GSK3A(2), GSK3B(3), IFI27(2), IGF1(1), INPPL1(2), IRS1(6), IRS2(3), IRS4(3), MET(4), NOLC1(4), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PARD3(7), PARD6A(1), PIK3CA(21), PIK3CD(5), PPP1R13B(4), PREX1(5), PTEN(7), PTK2(1), PTPN1(5), RPS6KA1(1), RPS6KA2(1), SOS1(3), SOS2(1), TSC1(10), TSC2(7), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1)	21060993	181	105	172	25	33	59	21	21	46	1	6.88e-06	0.992	1.000
225	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(4), CD3E(1), HLA-A(1), ICAM1(1), ITGAL(6), PRF1(4)	2368742	17	15	17	8	2	6	0	3	6	0	0.860	0.993	1.000
226	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB3(1), PSMB5(1), PSMB6(2), PSMB7(1), PSMC3(1), PSMD14(1), RPN1(3), RPN2(3), UBE3A(3)	3659562	22	18	22	5	3	9	2	4	4	0	0.311	0.993	1.000
227	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(4), AKT2(1), AKT3(2), GSK3A(2), GSK3B(3), IL4R(3), IRS1(6), IRS2(3), JAK1(3), JAK3(6), MAPK1(1), PIK3CA(21), PIK3CD(5), PIK3R1(5), PPP1R13B(4), RAF1(2), SOS1(3), SOS2(1), STAT6(3)	10039590	78	60	70	13	13	25	11	13	16	0	0.0202	0.994	1.000
228	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC2(4), AOC3(5), CES1(5), DDHD1(4), ESCO1(3), ESCO2(1), PLA1A(1), PPME1(1), PRDX6(3), SH3GLB1(2)	6815960	29	26	29	4	8	8	2	2	9	0	0.0473	0.994	1.000
229	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(4), HRAS(1), MAPK1(1), MAPK7(1), MEF2A(1), MEF2C(2), MEF2D(3), NTRK1(5), PIK3CA(21), PIK3R1(5), PLCG1(5), RPS6KA1(1)	5390256	50	42	42	10	10	20	5	6	9	0	0.0767	0.994	1.000
230	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(1), HLA-DRB1(1), IFNG(1), IFNGR1(1), IL12B(1), IL12RB2(5), IL18R1(1), IL2RA(1), IL4R(3)	3466155	16	14	16	4	0	6	2	5	3	0	0.622	0.994	1.000
231	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(5), IFNG(1), IKBKB(2), JUN(1), MAP3K1(8), MAP3K5(8), MAP4K5(6), MAPK14(1), MAPK8(1), NFKB1(2), TNFRSF9(1), TNFSF9(2), TRAF2(1)	5427842	39	28	39	9	7	11	6	5	10	0	0.460	0.995	1.000
232	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(2), ADORA2A(5), ADORA2B(2), ADORA3(1), P2RY1(2), P2RY6(2)	1518997	14	13	14	5	3	7	1	2	1	0	0.414	0.995	1.000
233	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASS(3), KARS(2)	1296491	6	6	6	3	1	2	1	1	1	0	0.860	0.995	1.000
234	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), FDXR(2), SHMT1(2)	4409891	19	18	19	4	5	4	2	5	3	0	0.346	0.995	1.000
235	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(4), DHCR7(3), FDFT1(2), FDPS(2), HMGCR(1), IDI1(1), LSS(2), MVK(1), SQLE(1)	3675562	17	17	17	4	2	10	1	0	4	0	0.402	0.996	1.000
236	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(4), EGFR(5), HGS(1), RAB5A(1), TF(4), TFRC(2)	3504948	19	17	19	5	2	11	4	0	2	0	0.376	0.996	1.000
237	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM3(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(2), CAMKK2(4), SYT1(3)	3213717	16	15	16	4	7	3	3	0	3	0	0.330	0.996	1.000
238	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(22), BMPR1B(4), DMC1(2), EGR1(2), ESR2(1), FSHR(6), INHA(1), LHCGR(6), MLH1(2), MSH5(1), NCOR1(4), NRIP1(3), PGR(5), PRLR(3), PTGER2(1), SMPD1(2), VDR(2), ZP2(1)	9437626	68	57	68	11	9	25	8	10	15	1	0.0153	0.996	1.000
239	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(2), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT5(1), DDOST(1), FUT8(2), MAN1A1(2), MAN1B1(2), MGAT1(1), MGAT2(1), MGAT3(3), MGAT4A(2), MGAT4B(2), MGAT5(3), RPN1(3), RPN2(3)	5383550	34	32	34	8	7	13	5	4	5	0	0.192	0.996	1.000
240	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(5), CREBBP(13), EP300(12), FADD(1), HDAC3(3), IKBKB(2), NFKB1(2), RIPK1(2), TNFRSF1B(1), TRAF6(1)	6102439	42	35	42	9	6	12	6	3	15	0	0.282	0.996	1.000
241	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO2(3), PAH(4), TAT(2), YARS(1)	2256562	11	11	11	4	1	3	3	2	2	0	0.672	0.997	1.000
242	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(1), EIF4EBP1(1), IFNG(1), IL1R1(1), NR4A3(2), WDR1(1)	2948940	8	8	8	2	2	2	0	0	4	0	0.356	0.997	1.000
243	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(5)	1874055	5	5	5	2	2	2	0	1	0	0	0.709	0.997	1.000
244	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), MDH1(2), ME1(1), PC(1), SLC25A1(1)	2561793	7	7	7	1	2	3	1	1	0	0	0.296	0.997	1.000
245	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B4GALT7(3), HS3ST1(4), HS3ST3A1(2), XYLT1(3), XYLT2(3)	1828015	15	13	15	5	6	4	1	1	3	0	0.567	0.997	1.000
246	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B4GALT7(3), HS3ST1(4), HS3ST3A1(2), XYLT1(3), XYLT2(3)	1828015	15	13	15	5	6	4	1	1	3	0	0.567	0.997	1.000
247	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(4), AKT2(1), AKT3(2), IARS(4), IL13RA1(1), IL2RG(3), IL4R(3), INPP5D(4), JAK1(3), JAK2(2), JAK3(6), NR0B2(1), PIK3CA(21), PPP1R13B(4), SERPINA4(4), SOS1(3), SOS2(1), STAT6(3), TYK2(3)	10222713	73	58	65	11	13	24	10	17	9	0	0.0112	0.997	1.000
248	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(4), EPHB2(4), F2(4), F2RL1(1), F2RL2(1), F2RL3(2), JUN(1), MAP2K5(2), MAPK1(1), MAPK7(1), MAPK8(1), MYEF2(2), PLD1(4), PLD2(3), PLD3(1), PTK2(1), RAF1(2), TEC(1), VAV1(8)	7570878	45	40	44	9	10	15	5	3	12	0	0.142	0.997	1.000
249	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(1), FUT9(4), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1)	2705823	11	11	11	3	4	4	1	2	0	0	0.438	0.997	1.000
250	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(3), MBTPS1(4), MBTPS2(5), SCAP(4), SREBF1(3), SREBF2(2)	3246479	21	18	20	6	4	9	1	3	4	0	0.389	0.997	1.000
251	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), LPO(3), MPO(3), PRDX1(2), PRDX2(1), PRDX6(3), TPO(8), TYR(3)	2686387	25	24	25	8	7	6	4	3	5	0	0.468	0.997	1.000
252	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF1(1), CSF3(2), IL3(2), IL6(1)	1714946	6	5	6	7	2	1	0	0	3	0	0.995	0.998	1.000
253	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(2), HSD3B7(2), RDH13(1)	1333296	5	5	5	3	1	2	0	1	1	0	0.801	0.998	1.000
254	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM3(1), CD3E(1), ELK1(2), FOS(1), FYN(1), HRAS(1), JUN(1), LCK(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), PIK3CA(21), PIK3R1(5), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), PTPN7(1), RAC1(1), RAF1(2), RASA1(9), SOS1(3), SYT1(3), VAV1(8), ZAP70(3)	13051025	109	72	101	16	23	40	12	11	23	0	0.00118	0.998	1.000
255	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(2), RPE(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1)	4789116	19	19	19	4	5	7	3	3	1	0	0.253	0.998	1.000
256	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ADSL(3), AGXT(2), ASL(3), ASNS(5), ASPA(2), CAD(11), CRAT(2), DDO(1), GAD1(3), GAD2(2), GPT(4), GPT2(1), PC(1)	7233311	43	36	43	6	14	12	6	5	6	0	0.0292	0.998	1.000
257	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), ALOX5(4), CYP1A2(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2E1(2), CYP2J2(1), CYP3A43(1), CYP3A5(2), CYP3A7(1), HSD3B7(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), RDH13(1)	6790113	35	28	35	6	11	14	2	4	4	0	0.0570	0.998	1.000
258	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), SHMT1(2)	4165043	17	16	17	4	4	3	2	5	3	0	0.468	0.998	1.000
259	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), SHMT1(2)	4165043	17	16	17	4	4	3	2	5	3	0	0.468	0.998	1.000
260	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), SHMT1(2)	4165043	17	16	17	4	4	3	2	5	3	0	0.468	0.998	1.000
261	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(8), CALM3(1), CAPN2(1), CAPNS1(3), CAPNS2(1), EP300(12), HDAC1(1), MEF2D(3), NFATC1(4), NFATC2(6), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), SYT1(3)	6558104	50	44	49	11	13	18	4	2	13	0	0.0837	0.999	1.000
262	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(2), LPO(3), MPO(3), MTHFR(2), PRDX6(3), SHMT1(2), SHMT2(2), TPO(8)	3180236	25	24	25	8	7	6	3	2	7	0	0.479	0.999	1.000
263	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(3), CP(3), CPOX(1), EPRS(3), FECH(1), GUSB(2), HCCS(2), HMBS(1), HMOX1(1), PPOX(4), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1), UROD(1), UROS(1)	7468091	37	34	37	6	9	12	5	5	6	0	0.0578	0.999	1.000
264	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(2), PTGS1(2)	1463913	5	4	5	3	1	3	0	0	1	0	0.789	0.999	1.000
265	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(2), COASY(1), DPYD(5), DPYS(4), ENPP1(5), ENPP3(4), ILVBL(1), PANK1(3), PANK2(4), PANK3(4), PANK4(4), PPCDC(1), VNN1(4)	4829209	42	40	42	11	5	23	4	4	6	0	0.266	0.999	1.000
266	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3)	1544872	9	9	9	7	4	3	0	1	1	0	0.948	0.999	1.000
267	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HRAS(1), PTK2B(4), SOS1(3)	2381055	8	8	8	3	1	3	0	2	2	0	0.787	0.999	1.000
268	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB7(1), NDUFS1(1), NDUFS2(2), NDUFV2(1)	1971862	8	6	8	3	4	2	0	0	2	0	0.624	0.999	1.000
269	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(4), ALDH5A1(1), CAD(11), CPS1(11), EARS2(1), EPRS(3), GAD1(3), GAD2(2), GCLC(1), GCLM(1), GFPT1(2), GFPT2(3), GLS(2), GLUD1(1), GLUD2(4), GLUL(2), GMPS(3), GPT(4), GPT2(1), GSR(3), NADSYN1(2), NAGK(2), QARS(3)	10865694	70	54	70	10	14	25	9	10	12	0	0.00836	0.999	1.000
270	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), HEMK1(1), LCMT1(1), METTL2B(1), PCYT1A(2), PCYT1B(3), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1)	3854921	17	15	17	4	4	8	1	1	3	0	0.331	0.999	1.000
271	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(1), ALDH18A1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(5), ARG1(1), ARG2(1), ASL(3), ASS1(1), CPS1(11), GATM(2), MAOA(2), MAOB(3), NAGS(1), ODC1(1), OTC(1), SAT1(1), SRM(3)	8066661	59	47	59	11	14	16	6	7	16	0	0.0620	0.999	1.000
272	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), AARS2(6), ADSL(3), ADSSL1(1), AGXT(2), ASL(3), ASNS(5), ASPA(2), ASRGL1(2), ASS1(1), CAD(11), CRAT(2), DARS2(2), DDO(1), DLAT(1), DLD(4), GAD1(3), GAD2(2), GPT(4), GPT2(1), NARS2(1), PC(1), PDHA2(5)	10502296	66	52	66	9	18	21	11	5	11	0	0.00647	0.999	1.000
273	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), ALDOC(4), FBP2(2), GPT(4), GPT2(1), MDH1(2), MDH2(2), ME1(1), ME2(3), ME3(1), PGK1(1), PKLR(3), RPE(1), RPIA(1), TKT(1)	4869690	29	27	29	7	8	11	1	2	7	0	0.238	0.999	1.000
274	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPN1(1), CAPNS1(3), CAPNS2(1), CDK5R1(1), CSNK1A1(2), CSNK1D(1), GSK3B(3), MAPT(1), PPP2CA(1)	2637756	17	15	17	5	3	8	3	0	3	0	0.380	0.999	1.000
275	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BET1L(1), BNIP1(1), GOSR1(1), GOSR2(1), SNAP25(1), STX10(1), STX11(1), STX12(1), STX16(3), STX17(2), STX18(1), STX19(2), STX2(1), STX5(1), STX6(2), VAMP4(2), VAMP5(1), VAMP8(1), VTI1A(3), YKT6(1)	4696263	29	28	29	7	7	9	5	4	4	0	0.345	0.999	1.000
276	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(3), ARG1(1), ARG2(1), ASL(3), CKB(2), CKM(1), CPS1(11), GAMT(1), GATM(2), GLUD1(1), NAGS(1), OAT(3), ODC1(1), OTC(1)	4944513	35	29	35	9	6	11	6	3	9	0	0.321	0.999	1.000
277	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CRY1(1), CRY2(2), CSNK1E(1), PER1(5)	2313732	11	10	11	5	3	4	1	0	3	0	0.717	0.999	1.000
278	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(4), GH1(1), GHR(2), HRAS(1), IGF1(1), IGF1R(4), PIK3CA(21), PIK3R1(5)	3597942	39	33	31	10	4	16	8	4	7	0	0.359	0.999	1.000
279	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(15), AXIN1(2), BTRC(3), CCND1(1), CREBBP(13), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTNNB1(9), FRAT1(1), FZD1(4), GSK3B(3), HDAC1(1), MAP3K7(3), NLK(4), PPP2CA(1), TLE1(2), WIF1(2), WNT1(1)	8075869	69	49	67	14	13	17	12	4	22	1	0.126	0.999	1.000
280	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), AMT(1), ATIC(2), ATP6V0C(1), GART(2), MTHFD1(2), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(7), SHMT1(2), SHMT2(2), TYMS(2)	4921193	33	30	33	9	3	13	8	5	4	0	0.372	0.999	1.000
281	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(4), MAP2K1(2), MAP2K2(3), MAP3K1(8), MAPK1(1), MAPK14(1), NFKB1(2), PIK3CA(21), PIK3R1(5), RB1(8), SP1(1)	5418502	56	44	48	13	8	19	7	5	17	0	0.306	0.999	1.000
282	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2D1(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), UBE2G2(1), UBE2H(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE3A(3)	2941220	16	15	16	5	1	7	0	5	3	0	0.664	1.000	1.000
283	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(7), AGT(1), AGTR2(2), EDNRA(1), EDNRB(3), EGF(4), EGFR(5), FOS(1), HRAS(1), JUN(1), NFKB1(2), PLCG1(5), PRKCA(1)	5583048	34	32	34	8	7	15	5	2	5	0	0.192	1.000	1.000
284	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(1), GNGT1(1), HTR2C(1), PLCB1(3), TUB(3)	1946427	11	11	11	5	2	3	1	3	2	0	0.802	1.000	1.000
285	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), DPYD(5), DPYS(4), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADHA(2), HIBCH(4), SRM(3)	7344068	45	37	45	9	14	19	3	3	6	0	0.0527	1.000	1.000
286	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(2), ADCY3(3), ADCY9(6), ARF1(1), ARF4(1), ARF5(1), ARF6(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), GNAS(16), PDIA4(3), PLCG1(5), PLCG2(3), PRKCA(1), SEC61A1(3), SEC61A2(1), TRIM23(2)	10180114	67	55	66	12	25	20	7	8	7	0	0.0162	1.000	1.000
287	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), DDC(2), EPX(2), LPO(3), MAOA(2), MAOB(3), MPO(3), PRDX1(2), PRDX2(1), PRDX6(3), TAT(2), TPO(8)	6134079	45	40	45	10	15	8	4	7	11	0	0.0847	1.000	1.000
288	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(1), BIRC3(2), CASP7(1), CASP8(6), CASP9(1), DFFA(1), DFFB(2), PRF1(4), SCAP(4), SREBF1(3), SREBF2(2)	4969809	30	28	30	8	8	11	2	4	5	0	0.370	1.000	1.000
289	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(4), ALDH5A1(1), CAD(11), CPS1(11), EPRS(3), GAD1(3), GAD2(2), GCLC(1), GCLM(1), GFPT1(2), GLS(2), GLUD1(1), GLUL(2), GMPS(3), GPT(4), GPT2(1), NADSYN1(2), QARS(3)	9126465	57	46	57	10	13	19	8	8	9	0	0.0559	1.000	1.000
290	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(1), ACP5(1), ACPP(3), ENPP1(5), ENPP3(4), FLAD1(1), RFK(1), TYR(3)	2694367	19	19	19	7	2	9	3	2	3	0	0.729	1.000	1.000
291	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CRY1(1), CRY2(2), CSNK1D(1), CSNK1E(1), NPAS2(4), NR1D1(2), PER1(5), PER2(5), PER3(5)	4614200	28	22	28	7	8	13	2	1	4	0	0.174	1.000	1.000
292	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(2), CYP11B1(2), CYP11B2(4), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3)	2740879	19	15	19	6	5	10	1	1	2	0	0.461	1.000	1.000
293	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(2), CYP11B1(2), CYP11B2(4), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3)	2740879	19	15	19	6	5	10	1	1	2	0	0.461	1.000	1.000
294	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(5), CARS2(2), LDHAL6A(3), LDHAL6B(1), SDS(1), SULT1C2(2)	3507694	14	11	14	4	5	6	0	2	1	0	0.386	1.000	1.000
295	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(4), AKT2(1), AKT3(2), ILK(2), MAPK1(1), PIK3CA(21), PIK3CD(5), PTEN(7), PTK2B(4), RBL2(4), SOS1(3)	5503879	54	44	46	12	5	24	6	9	9	1	0.210	1.000	1.000
296	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM3(1), CCR5(1), CXCR4(1), FOS(1), GNAQ(1), JUN(1), MAPK14(1), MAPK8(1), PLCG1(5), PRKCA(1), PTK2B(4), SYT1(3)	3755123	21	21	21	6	6	7	2	1	5	0	0.425	1.000	1.000
297	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(4), MAF(1), MAPK14(1), NFATC1(4), NFATC2(6), PRKAR1B(2), PRKAR2B(3)	3262568	21	16	21	7	7	4	3	1	6	0	0.555	1.000	1.000
298	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(4), LARS(4), LARS2(2), PDHA2(5)	2698533	15	15	15	5	1	4	4	3	3	0	0.717	1.000	1.000
299	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(3), NFKB1(2), NOX1(1), XDH(9)	2757859	15	15	15	5	0	6	5	1	3	0	0.642	1.000	1.000
300	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(2), PLCB1(3), PRKCA(1)	2262604	7	7	7	5	0	4	0	1	2	0	0.942	1.000	1.000
301	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(4), AVP(1), CABIN1(8), CALM3(1), CAMK1(1), CAMK1G(2), HDAC5(2), IGF1(1), IGF1R(4), INSR(9), MAPK14(1), MAPK7(1), MEF2A(1), MEF2C(2), MEF2D(3), MYOD1(1), NFATC1(4), NFATC2(6), PIK3CA(21), PIK3R1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), SYT1(3)	9542446	87	65	78	19	22	28	10	7	20	0	0.0292	1.000	1.000
302	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(5), IKBKAP(6), IKBKB(2), MAP3K1(8), NFKB1(2), TNFAIP3(5), TRAF3(1), TRAF6(1)	5059398	30	24	30	7	3	8	4	6	9	0	0.506	1.000	1.000
303	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(6), COPA(8), GBF1(5), GPLD1(2), KDELR1(1), KDELR2(2)	4447722	25	21	25	7	6	7	4	5	3	0	0.463	1.000	1.000
304	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR161(6), GPR18(1), GPR34(1), GPR39(1), GPR45(1), GPR68(1), GPR75(1)	2554947	13	12	13	5	5	3	4	1	0	0	0.551	1.000	1.000
305	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(1), CD3E(1), ICAM1(1), ITGAL(6), PTPRC(9)	2887395	19	18	19	7	1	12	2	1	3	0	0.506	1.000	1.000
306	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(1), CXCR3(1), ETV5(2), IFNG(1), IL12B(1), IL12RB2(5), IL18R1(1), JAK2(2), JUN(1), MAPK14(1), MAPK8(1), STAT4(5), TYK2(3)	5190287	26	25	26	7	5	8	3	5	5	0	0.444	1.000	1.000
307	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(1), ACP5(1), ACPP(3), ALPL(1), ALPP(5), CYP3A43(1), CYP3A5(2), CYP3A7(1), DHRS1(1), DHRS3(2), DHRSX(1), PON1(1), PON2(2), PON3(4)	4956073	26	23	26	7	5	6	5	3	7	0	0.415	1.000	1.000
308	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDFT1(2), FDPS(2), HMGCR(1), IDI1(1), LSS(2), MVK(1), NQO1(1), NQO2(1), SQLE(1), VKORC1(1)	3085867	16	15	16	5	2	8	2	1	3	0	0.554	1.000	1.000
309	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(2), CYP51A1(4), DHCR7(3), FDFT1(2), FDPS(2), GGCX(2), HMGCR(1), IDI1(1), IDI2(1), LSS(2), MVK(1), NQO1(1), SQLE(1), VKORC1(1)	5318329	24	23	24	5	5	13	1	1	4	0	0.195	1.000	1.000
310	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(2), ALOX15(2), ALOX15B(2), ALOX5(4), ALOX5AP(1), DPEP1(1), LTA4H(1), PLA2G6(3), PTGDS(2), PTGIS(2), PTGS1(2), TBXAS1(2)	4389941	24	20	24	7	12	5	1	1	5	0	0.343	1.000	1.000
311	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL1(2), FOSL2(1), IFNAR1(1), IFNB1(1), MAPK8(1), NFKB1(2), TNFRSF11A(1), TRAF6(1)	3042812	11	10	11	4	1	4	2	0	4	0	0.745	1.000	1.000
312	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(2), HRAS(1), INSR(9), IRS1(6), JAK2(2), MAP2K1(2), MAPK1(1), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), RAF1(2), RPS6KA1(1), SOS1(3), STAT5A(3), STAT5B(2)	9085069	67	57	59	14	13	25	9	9	11	0	0.0785	1.000	1.000
313	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS3(2), DHRSX(1), ESCO1(3), ESCO2(1), SH3GLB1(2)	4287148	10	10	10	2	2	3	1	0	4	0	0.536	1.000	1.000
314	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(5), ANAPC2(2), ANAPC4(2), ANAPC5(3), ANAPC7(1), BTRC(3), CDC20(3), CDC23(1), CDC26(1), CDC27(7), CUL1(4), CUL2(1), CUL3(3), FBXW7(14), FZR1(4), ITCH(3), SMURF1(2), SMURF2(2), UBA1(4), UBE2D1(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), WWP1(6), WWP2(3)	11165380	81	57	79	16	10	26	6	14	24	1	0.166	1.000	1.000
315	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GABBR1(2), GPRC5A(2), GPRC5B(3), GPRC5C(3), GRM1(9), GRM2(3), GRM3(9), GRM4(7), GRM5(5), GRM7(3), GRM8(11)	5612865	60	49	60	16	20	17	8	7	8	0	0.135	1.000	1.000
316	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), CRK(1), DOCK1(9), ELK1(2), FOS(1), GAB1(1), HGF(2), HRAS(1), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK8(1), MET(4), PAK1(2), PIK3CA(21), PIK3R1(5), PTEN(7), PTK2(1), PTK2B(4), PTPN11(2), PXN(3), RAF1(2), RAP1A(1), RASA1(9), SOS1(3), STAT3(2)	12538330	96	71	88	20	13	45	9	11	17	1	0.0520	1.000	1.000
317	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), LCT(8), PGM1(1), PYGL(3), PYGM(4)	3816428	17	14	17	5	3	8	2	1	3	0	0.500	1.000	1.000
318	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3E(1), CREBBP(13), CSK(2), GNAS(16), GNGT1(1), HLA-DRB1(1), LCK(1), PRKAR1B(2), PRKAR2B(3), PTPRC(9), ZAP70(3)	6288927	57	46	57	13	16	18	5	3	15	0	0.152	1.000	1.000
319	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3E(1), CREBBP(13), CSK(2), GNAS(16), GNGT1(1), HLA-DRB1(1), LCK(1), PRKAR1B(2), PRKAR2B(3), PTPRC(9), ZAP70(3)	6288927	57	46	57	13	16	18	5	3	15	0	0.152	1.000	1.000
320	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(4), AKT2(1), AKT3(2), BCR(4), BTK(1), CDKN2A(19), DAPP1(1), FLOT2(5), GAB1(1), ITPR1(6), ITPR2(8), ITPR3(2), LYN(2), NR0B2(1), PIK3CA(21), PITX2(1), PLCG2(3), PPP1R13B(4), PREX1(5), PTEN(7), PTPRC(9), RPS6KA1(1), RPS6KA2(1), SAG(1), SYK(2), TEC(1), VAV1(8)	15437326	121	87	112	23	18	46	13	17	26	1	0.00660	1.000	1.000
321	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(2), CR2(4), FCGR2B(1), HLA-DRB1(1), ICAM1(1), ITGAL(6), PTPRC(9)	4195132	25	24	24	9	3	11	2	2	7	0	0.650	1.000	1.000
322	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(4), AKT2(1), AKT3(2), BRD4(8), CBL(6), CDKN2A(19), F2RL2(1), FLOT2(5), GSK3A(2), GSK3B(3), INPPL1(2), IRS1(6), IRS2(3), IRS4(3), LNPEP(3), MAPK1(1), PARD3(7), PARD6A(1), PIK3CA(21), PIK3CD(5), PIK3R1(5), PTEN(7), PTPN1(5), RAF1(2), RPS6KA1(1), RPS6KA2(1), SERPINB6(1), SORBS1(7), SOS1(3), SOS2(1), YWHAB(1), YWHAG(3), YWHAQ(1), YWHAZ(1)	16042355	142	92	133	29	28	44	14	15	40	1	0.0219	1.000	1.000
323	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(4), ACADL(5), ACADS(2), ACADSB(1), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), AOX1(4), BCKDHA(2), BCKDHB(3), ECHS1(1), EHHADH(1), HADHA(2), IVD(1), MCCC1(1), MCCC2(3), MCEE(1), MUT(3), PCCA(3), PCCB(1), SDS(1)	9879172	63	51	63	12	11	28	6	2	16	0	0.0882	1.000	1.000
324	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB3(1), PSMB5(1), PSMB6(2), PSMB7(1)	2400666	11	9	11	6	2	4	1	2	2	0	0.880	1.000	1.000
325	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(6), ESR2(1), PDE1A(3), PDE1B(3), PLCB1(3), PLCB2(1), PRL(2), VIP(2)	3016367	21	20	21	9	8	4	5	1	3	0	0.740	1.000	1.000
326	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT4(3), AGPAT6(1), AGPS(4), ENPP6(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLD1(4), PLD2(3), PPAP2A(2), PPAP2B(3)	6522519	36	32	34	9	10	12	5	2	7	0	0.306	1.000	1.000
327	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(3), CASP9(1), DAXX(3), FASLG(1), HSPB2(1), MAPKAPK2(1)	3069836	11	10	11	8	3	2	2	1	3	0	0.959	1.000	1.000
328	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGAL(6), ITGAM(3), SELE(3), SELL(1)	2959112	14	14	13	9	3	6	1	1	3	0	0.906	1.000	1.000
329	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(6), CRK(1), CXCR4(1), GNAI1(1), GNAQ(1), GNGT1(1), HRAS(1), MAP2K1(2), MAPK1(1), NFKB1(2), PIK3C2G(4), PIK3CA(21), PIK3R1(5), PLCG1(5), PRKCA(1), PTK2(1), PTK2B(4), PXN(3), RAF1(2)	7793307	63	49	55	14	11	27	7	8	10	0	0.0957	1.000	1.000
330	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(1), ACP5(1), ACPP(3), ENPP1(5), ENPP3(4), FLAD1(1), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), RFK(1), TYR(3)	4151358	27	24	26	9	2	13	4	2	6	0	0.673	1.000	1.000
331	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(2), ITPKB(6), MIOX(2), PIK3C2A(3), PIK3C2B(5), PIK3C2G(4), PIK3CA(21), PIK3CB(4), PIK3CG(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCG1(5), PLCG2(3)	12508173	83	61	75	14	12	43	6	10	12	0	0.00707	1.000	1.000
332	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(3), CSF1(1), FCGR3A(1), IL1B(3), IL6R(1), SELL(1), SPN(1), TGFB2(1), TNFRSF1B(1), TNFRSF8(5)	3828853	18	16	18	6	4	6	3	1	4	0	0.415	1.000	1.000
333	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(1), CD3E(1), ICAM1(1), ITGAL(6), PTPRC(9)	3044520	19	18	19	8	1	12	2	1	3	0	0.619	1.000	1.000
334	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(5), ERBB3(6), NRG1(8), UBE2D1(1)	2803358	24	22	23	9	4	11	6	1	2	0	0.661	1.000	1.000
335	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(1), CD3E(1), CXCR3(1), IFNG(1), IL12B(1), IL12RB2(5), JAK2(2), STAT4(5), TYK2(3)	4090422	21	21	21	7	3	7	3	4	4	0	0.595	1.000	1.000
336	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), JUN(1), OPRK1(2), POLR2A(3), PRKAR1B(2), PRKAR2B(3)	3486334	12	11	12	6	3	4	1	0	4	0	0.854	1.000	1.000
337	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(4), ACOX3(1), ELOVL2(2), ELOVL5(2), ELOVL6(2), FADS1(1), FADS2(2), FASN(7), HADHA(2), SCD(3)	4151496	26	20	25	9	4	10	0	3	9	0	0.579	1.000	1.000
338	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH4A1(4), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(5), ARG1(1), ARG2(1), ASL(3), CKB(2), CKM(1), CPS1(11), DAO(1), GAMT(1), GATM(2), GLUD1(1), MAOA(2), MAOB(3), NOS1(6), NOS3(5), OAT(3), ODC1(1), OTC(1), P4HA1(1), P4HA2(3), P4HA3(1), P4HB(2), RARS(4)	12237731	89	67	89	17	26	26	9	8	20	0	0.0149	1.000	1.000
339	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), FUT1(1), FUT9(4), ST3GAL1(2), ST3GAL2(2)	2855337	10	10	10	4	4	3	1	2	0	0	0.697	1.000	1.000
340	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), IL6(1), IL6R(1), IL6ST(5), JAK1(3), JAK2(2), JAK3(6), JUN(1), MAP2K1(2), PTPN11(2), RAF1(2), SOS1(3), STAT3(2)	6652040	35	32	35	9	11	10	4	6	4	0	0.278	1.000	1.000
341	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), IL22RA1(2), IL22RA2(1), JAK1(3), JAK2(2), JAK3(6), SOCS3(1), STAT1(3), STAT3(2), STAT5A(3), STAT5B(2), TYK2(3)	5227685	31	26	30	9	10	7	3	4	7	0	0.373	1.000	1.000
342	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(5), ARHGEF1(3), F2(4), F2R(4), F2RL3(2), GNA12(1), GNA13(3), GNAI1(1), GNAQ(1), GNGT1(1), MAP3K7(3), PIK3CA(21), PIK3R1(5), PLCB1(3), PPP1R12B(1), PRKCA(1), PTK2B(4), ROCK1(2)	7113041	65	52	56	15	7	26	8	9	15	0	0.216	1.000	1.000
343	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IFNG(1), IL10(2), IL12B(1), IL15(1), IL16(3), IL3(2), IL6(1)	2684908	12	8	12	5	3	5	1	2	1	0	0.609	1.000	1.000
344	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(1), HK1(1), PFKL(1), PGK1(1), PKLR(3)	2579841	9	8	9	6	3	2	2	0	2	0	0.867	1.000	1.000
345	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(8), ACADL(5), ACADSB(1), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(1), HADHA(2), MCEE(1), MUT(3), PCCA(3), PCCB(1), SDS(1), SUCLG1(2), SUCLG2(1)	9053586	54	44	53	11	13	18	7	3	13	0	0.177	1.000	1.000
346	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(1), CD2(1), CD33(2), CD5(2), CD7(1), IFNB1(1), IFNG(1), IL10(2), IL12B(1), IL3(2), ITGAX(2), TLR2(5), TLR4(6), TLR7(1)	4935203	28	23	28	9	4	10	8	1	5	0	0.473	1.000	1.000
347	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCRL(1), CD97(3), CRHR1(2), ELTD1(4), EMR1(7), EMR2(2), GHRHR(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(9), LPHN3(9)	7493484	47	39	45	10	7	16	11	4	9	0	0.0695	1.000	1.000
348	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(1), GFPT1(2), GNE(1), HK1(1), HK2(3), HK3(2), RENBP(2), UAP1(1)	4695914	14	14	14	4	5	5	0	1	3	0	0.450	1.000	1.000
349	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), AOX1(4), ASMT(4), CYP19A1(1), CYP1A1(3), CYP1A2(1), CYP2A13(4), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(1), CYP3A5(2), CYP3A7(1), CYP4B1(1), CYP51A1(4), DDC(2), ECHS1(1), EHHADH(1), GCDH(1), HADHA(2), KMO(1), KYNU(2), MAOA(2), MAOB(3), SDS(1), TDO2(1), TPH1(2), WARS(1), WARS2(2)	15254187	96	69	96	18	27	35	5	12	17	0	0.00893	1.000	1.000
350	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), FOS(1), HRAS(1), IL2RA(1), IL2RG(3), JAK1(3), JAK3(6), JUN(1), LCK(1), MAP2K1(2), MAPK8(1), RAF1(2), SOS1(3), STAT5A(3), STAT5B(2), SYK(2)	6605526	35	27	35	8	11	8	4	7	5	0	0.228	1.000	1.000
351	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(8), ACAT1(3), ACAT2(1), ACYP1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), DLAT(1), DLD(4), GLO1(1), GRHPR(2), HAGH(1), MDH1(2), MDH2(2), ME1(1), ME2(3), ME3(1), PC(1), PCK1(2), PDHA2(5), PKLR(3)	10065443	60	49	60	12	15	25	7	3	10	0	0.0572	1.000	1.000
352	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(2), HRAS(1), KLK2(1), MAP2K1(2), MAP2K2(3), MAPK1(1), NGFR(2), RAF1(2)	2324362	15	15	15	7	7	5	2	1	0	0	0.610	1.000	1.000
353	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(15), AXIN1(2), AXIN2(2), BTRC(3), CACYBP(2), CAMK2A(3), CAMK2B(2), CCND1(1), CER1(1), CHD8(9), CREBBP(13), CSNK1A1(2), CSNK1A1L(1), CSNK1E(1), CSNK2A1(1), CSNK2A2(1), CTBP2(2), CTNNB1(9), CTNNBIP1(1), CUL1(4), CXXC4(1), DAAM1(6), DAAM2(6), DKK2(3), DKK4(2), DVL2(1), DVL3(2), EP300(12), FOSL1(2), FRAT1(1), FZD1(4), FZD10(2), FZD2(4), FZD3(1), FZD5(1), FZD6(4), FZD7(3), FZD9(3), GSK3B(3), JUN(1), LRP5(4), LRP6(8), MAP3K7(3), MAPK10(3), MAPK8(1), MAPK9(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NKD2(5), NLK(4), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PORCN(1), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRICKLE1(4), PRICKLE2(2), PRKACA(3), PRKCA(1), PRKCG(2), PSEN1(2), RAC1(1), RHOA(3), ROCK1(2), ROCK2(4), SENP2(3), SFRP1(2), SFRP2(1), SFRP4(3), SMAD2(2), SMAD3(3), SMAD4(14), SOX17(3), TBL1X(2), TBL1XR1(3), TCF7L1(2), TP53(174), VANGL1(3), VANGL2(4), WIF1(2), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT3A(1), WNT5B(2), WNT7B(3), WNT8B(1), WNT9A(2), WNT9B(2)	43675580	478	175	403	73	130	121	54	45	124	4	2.71e-11	1.000	1.000
354	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR3(1), RAC1(1), WASF1(3), WASL(2)	2270085	8	8	8	5	2	1	1	3	1	0	0.937	1.000	1.000
355	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(5), MAPK14(1), MAPK8(1), NFKB1(2), TNFSF13B(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(1)	4059716	16	14	16	5	2	6	1	2	5	0	0.701	1.000	1.000
356	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(3), ARRB2(1), CALM3(1), CAMK2A(3), CAMK2B(2), CLCA2(4), CLCA4(2), CNGA3(4), CNGA4(1), CNGB1(2), GNAL(2), GUCA1A(1), GUCA1B(2), GUCA1C(2), PDE1C(3), PRKACA(3), PRKG1(3), PRKG2(5)	8420096	47	41	47	10	10	16	12	1	8	0	0.106	1.000	1.000
357	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR3(1), NCK1(1), NCKAP1(4), NTRK1(5), PIR(2), PSMA7(1), RAC1(1), WASF1(3), WASF2(3), WASF3(3), WASL(2)	4259659	27	25	27	9	8	5	3	6	5	0	0.674	1.000	1.000
358	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(3), BTK(1), CALM3(1), CD79A(2), ELK1(2), FOS(1), HRAS(1), JUN(1), LYN(2), MAP2K1(2), MAP3K1(8), MAPK14(1), MAPK8(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), RAC1(1), RAF1(2), SOS1(3), SYK(2), SYT1(3), VAV1(8)	10386054	73	55	73	15	21	22	8	6	16	0	0.0604	1.000	1.000
359	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFA(1), DFFB(2), ENDOG(1), HMGB1(1), HMGB2(1), TOP2A(7), TOP2B(8)	2919291	22	20	22	8	5	13	2	1	1	0	0.783	1.000	1.000
360	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS1(1), DHRS3(2), DHRSX(1), HEMK1(1), LCMT1(1), METTL2B(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1)	4060680	16	14	16	5	3	6	1	1	5	0	0.589	1.000	1.000
361	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(2), HEMK1(1), LCMT1(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), METTL2B(1), PAPSS2(3), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), SCLY(2), SEPHS1(3), SEPHS2(2)	6934007	31	24	31	7	7	11	3	4	6	0	0.173	1.000	1.000
362	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), CSF3(2), HLA-DRB1(1), IFNB1(1), IFNG(1), IL10(2), IL12B(1), IL15(1), IL3(2), IL6(1), PDGFA(2), TGFB2(1), TGFB3(2)	3721512	18	16	18	8	4	6	2	2	4	0	0.819	1.000	1.000
363	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM3(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(2), ESRRA(2), HDAC5(2), MEF2A(1), MEF2C(2), MEF2D(3), PPARA(1), PPP3CA(1), PPP3CB(2), PPP3CC(3), SYT1(3)	5740051	29	27	29	9	11	8	1	1	8	0	0.361	1.000	1.000
364	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(9), DDX20(1), E2F1(2), ETS1(1), ETV3(3), FOS(1), HDAC5(2), HRAS(1), JUN(1), NCOR2(12), RBL1(2), RBL2(4), SIN3A(5), SIN3B(3)	7486294	48	41	48	11	10	18	5	5	10	0	0.185	1.000	1.000
365	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1L(1), GTF2A2(1), GTF2E1(1), GTF2F1(5), GTF2H1(1), GTF2H3(1), GTF2I(2), GTF2IRD1(6), STON1(3), TAF1(5), TAF10(1), TAF1L(8), TAF2(5), TAF4(2), TAF4B(3), TAF5(2), TAF5L(5), TAF6(1), TAF6L(2), TAF7(1), TAF7L(2), TAF9B(1), TBPL1(1), TBPL2(2)	9865842	62	53	62	14	10	21	14	9	8	0	0.154	1.000	1.000
366	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(1), C1GALT1(1), GALNT10(2), GALNT11(1), GALNT12(3), GALNT13(5), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(2), GALNT7(2), GALNT8(5), GALNT9(3), GALNTL5(2), GCNT1(3), GCNT3(1), GCNT4(4), OGT(3), ST3GAL1(2), ST3GAL2(2), ST6GALNAC1(2), WBSCR17(10)	8858614	62	54	62	15	16	15	14	9	8	0	0.175	1.000	1.000
367	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(2), ALDOC(4), FBP2(2), FPGT(5), GCK(1), GMDS(1), GMPPA(1), HK1(1), HK2(3), HK3(2), PFKFB1(2), PFKFB3(2), PFKFB4(1), PFKM(4), PFKP(2), PMM1(1), PMM2(1)	6640440	35	28	35	9	10	13	2	3	7	0	0.195	1.000	1.000
368	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLRMT(3)	3740337	14	14	13	6	4	5	1	1	3	0	0.768	1.000	1.000
369	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(6), COL4A3(4), COL4A4(6), COL4A5(7), COL4A6(4), F10(2), F11(4), F12(2), F2(4), F2R(4), F5(4), F8(7), F9(1), FGA(4), FGB(3), FGG(1), KLKB1(1), PROC(1), PROS1(5), SERPING1(2)	12194676	74	55	73	14	14	29	9	9	13	0	0.0690	1.000	1.000
370	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(1), GCLC(1), GCLM(1), GSTM3(1), GSTM5(1), GSTP1(1), IDH1(1), IDH2(4), MGST3(2), PGD(1)	5094863	14	14	14	4	2	8	1	2	1	0	0.429	1.000	1.000
371	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(4), B3GNT2(1), B3GNT7(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), CHST1(1), CHST6(2), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1)	3305825	24	22	24	9	6	8	5	4	1	0	0.599	1.000	1.000
372	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(2), RPE(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1), XYLB(1)	7374600	24	23	24	5	5	10	3	3	3	0	0.214	1.000	1.000
373	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	GORASP1(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MAPKAPK5(2), NFKB1(2), NFKB2(2), PIK3CA(21), PIK3CD(5), PIK3R1(5), SYT1(3), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(1)	9534485	64	51	56	14	13	21	6	7	17	0	0.0977	1.000	1.000
374	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), ALDOC(4), FBP2(2), GPT(4), GPT2(1), MDH1(2), MDH2(2), ME1(1), ME3(1), PGK1(1), PGK2(1), PKLR(3), RPE(1), RPIA(1), TKT(1), TKTL1(1)	5417427	28	25	28	9	7	10	1	3	7	0	0.514	1.000	1.000
375	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(8), ACACB(9), ACAT1(3), ACAT2(1), ACSS1(2), ACSS2(8), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(1), HADHA(2), HIBCH(4), LDHAL6A(3), LDHAL6B(1), MCEE(1), MUT(3), PCCA(3), PCCB(1), SUCLG1(2), SUCLG2(1)	10835069	67	54	66	15	15	28	5	7	12	0	0.143	1.000	1.000
376	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BIRC2(1), BIRC3(2), CASP8(6), CFLAR(2), FADD(1), JUN(1), MAP2K4(3), MAP3K3(1), MAP3K7(3), NFKB1(2), NFKB2(2), NR2C2(4), RALBP1(2), RIPK1(2), TNFAIP3(5), TNFRSF1B(1), TRAF2(1)	7723449	39	30	38	9	9	11	2	7	10	0	0.213	1.000	1.000
377	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(4), BCR(4), FOS(1), HRAS(1), JAK2(2), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK8(1), PIK3CA(21), PIK3R1(5), RAF1(2), SOS1(3), STAT1(3), STAT5A(3), STAT5B(2)	7723257	66	48	58	16	11	25	7	10	13	0	0.216	1.000	1.000
378	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(4), AKT2(1), AKT3(2), BRAF(4), EIF4EBP1(1), HIF1A(5), IGF1(1), MAPK1(1), PGF(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PRKAA1(2), PRKAA2(1), RHEB(1), RICTOR(6), RPS6KA1(1), RPS6KA2(1), RPS6KA6(4), STK11(5), TSC1(10), TSC2(7), ULK1(3), ULK2(2), ULK3(3), VEGFC(5)	14795621	115	77	107	24	18	41	17	13	25	1	0.0244	1.000	1.000
379	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(3), JAK2(2), JAK3(6), MAPK1(1), STAT3(2), TYK2(3)	3333906	17	17	17	7	4	3	4	4	2	0	0.803	1.000	1.000
380	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(5), ACADS(2), ACAT1(3), ACAT2(1), ACSM1(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH5A1(1), ALDH9A1(1), BDH1(1), BDH2(4), DDHD1(4), ECHS1(1), EHHADH(1), GAD1(3), GAD2(2), HADH(1), HADHA(2), HMGCS2(2), HSD17B4(4), HSD3B7(2), ILVBL(1), L2HGDH(3), OXCT2(1), PDHA2(5), PLA1A(1), PPME1(1), PRDX6(3), RDH13(1)	11194529	67	51	67	14	12	31	4	7	13	0	0.0635	1.000	1.000
381	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(8), ACACB(9), ACAT1(3), ACAT2(1), ACOT12(2), ACSS1(2), ACSS2(8), ACYP1(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), DLAT(1), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHAL6A(3), LDHAL6B(1), MDH1(2), MDH2(2), ME1(1), ME2(3), ME3(1), PC(1), PCK1(2), PCK2(2), PDHA2(5), PKLR(3)	12696780	80	61	80	17	18	36	7	7	12	0	0.0350	1.000	1.000
382	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(5), ASRGL1(2), CA1(3), CA14(2), CA3(1), CA4(2), CA5A(1), CA6(1), CA7(1), CPS1(11), GLS(2), GLUD1(1), GLUD2(4), GLUL(2), HAL(1)	5799709	40	32	40	11	3	15	7	7	8	0	0.424	1.000	1.000
383	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(15), AXIN1(2), BMP10(1), BMP2(1), BMP5(1), BMP7(2), BMPR1A(1), BMPR2(3), CHRD(5), CTNNB1(9), FZD1(4), GSK3B(3), MAP3K7(3), MEF2C(2), NKX2-5(3), NOG(1), RFC1(5), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15), TGFBR3(3), WNT1(1)	9790669	86	62	81	22	14	22	15	10	24	1	0.433	1.000	1.000
384	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(4), BCL2L1(1), CBL(6), CFLAR(2), E2F1(2), FOS(1), HRAS(1), IL2RA(1), IL2RG(3), IRS1(6), JAK1(3), JAK3(6), MAPK1(1), PIK3CA(21), PIK3R1(5), RAF1(2), SOCS3(1), SOS1(3), STAT5A(3), STAT5B(2), SYK(2)	10105007	76	54	68	17	11	25	10	18	12	0	0.134	1.000	1.000
385	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(2), EPOR(2), HIF1A(5), JAK2(2), NFKB1(2)	3532655	13	13	13	6	2	6	0	3	2	0	0.810	1.000	1.000
386	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(2), IDUA(1), LCT(8), NAGLU(3)	4024338	21	18	21	8	5	6	4	3	3	0	0.727	1.000	1.000
387	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(5), IKBKAP(6), IKBKB(2), MAP3K1(8), NFKB1(2), RIPK1(2), TANK(3), TNFAIP3(5), TNFRSF1B(1), TRAF1(2), TRAF2(1), TRAF3(1)	6170506	38	31	38	10	8	8	5	8	9	0	0.485	1.000	1.000
388	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), DDC(2), EPX(2), ESCO1(3), ESCO2(1), LPO(3), MAOA(2), MAOB(3), MIF(1), MPO(3), PRDX6(3), SH3GLB1(2), TAT(2), TPO(8)	9280965	49	42	49	11	16	10	3	6	14	0	0.105	1.000	1.000
389	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), ALDOC(4), FBP2(2), H6PD(1), PFKM(4), PFKP(2), PGD(1), PGLS(2), PGM1(1), PRPS1(1), PRPS2(2), RBKS(1), RPE(1), RPIA(1), TKT(1)	5514466	26	24	26	8	5	13	2	3	3	0	0.408	1.000	1.000
390	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), AOC2(4), AOC3(5), ASPA(2), DDC(2), HAL(1), HARS(1), HDC(2), HNMT(1), MAOA(2), MAOB(3), PRPS1(1), PRPS2(2)	6689348	46	38	46	13	14	11	5	8	8	0	0.318	1.000	1.000
391	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA2(4), ACADS(2), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH6A1(2), ALDH9A1(1), AOX1(4), BCAT2(2), BCKDHA(2), BCKDHB(3), DBT(2), DLD(4), ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HIBCH(4), HMGCS2(2), HSD17B4(4), IVD(1), MCCC1(1), MCCC2(3), MCEE(1), MUT(3), OXCT2(1), PCCA(3), PCCB(1)	11874394	69	55	69	15	10	37	5	2	15	0	0.153	1.000	1.000
392	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), HRAS(1), JUN(1), MAP2K1(2), MAPK1(1), NFKB1(2), PLCB1(3), PRKCA(1), RAF1(2)	4229590	14	14	14	9	3	5	2	1	3	0	0.941	1.000	1.000
393	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(4), POLR1B(3), POLR1C(5), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3A(10), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1)	6344405	38	30	38	10	11	10	5	1	11	0	0.350	1.000	1.000
394	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(5), MAP2K1(2), MAP3K1(8), MAPK14(1), NCOR2(12), THRA(6), THRB(1)	4838135	39	31	39	12	12	14	4	2	7	0	0.414	1.000	1.000
395	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(5), EPRS(3), GARS(3), HARS(1), IARS(4), KARS(2), LARS(4), LARS2(2), MARS(3), MARS2(1), QARS(3), RARS(4), SARS(2), TARS(6), WARS(1), WARS2(2), YARS(1)	8665429	50	41	50	12	12	20	6	7	5	0	0.208	1.000	1.000
396	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), RPL10A(1), RPL10L(5), RPL11(2), RPL13(1), RPL13A(1), RPL18A(1), RPL26(1), RPL28(1), RPL3(2), RPL30(1), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL36AL(1), RPL37A(1), RPL38(1), RPL3L(1), RPL6(1), RPL8(2), RPS10(1), RPS11(2), RPS13(2), RPS24(1), RPS26(2), RPS5(2), RPS9(1)	6461598	39	30	39	9	9	10	5	7	8	0	0.391	1.000	1.000
397	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(5), AASS(3), ACAT1(3), ACAT2(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), ATP6V0C(1), BBOX1(2), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(6), EHMT2(4), GCDH(1), HADHA(2), PLOD1(3), PLOD2(3), PLOD3(4), SDS(1), SHMT1(2), SHMT2(2), TMLHE(1)	10130832	70	55	70	17	15	31	8	3	13	0	0.131	1.000	1.000
398	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), AMT(1), ATIC(2), FTCD(2), GART(2), MTFMT(1), MTHFD1(2), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(7), SHMT1(2), SHMT2(2), TYMS(2)	5220380	35	31	35	11	4	12	8	5	6	0	0.553	1.000	1.000
399	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(3), PRPS2(2), SRM(3)	3588424	16	12	16	6	7	2	2	2	3	0	0.670	1.000	1.000
400	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), AP2A1(1), BIN1(1), CALM3(1), DNM1(4), EPN1(4), EPS15(3), PICALM(2), PPP3CA(1), PPP3CB(2), PPP3CC(3), SYNJ1(7), SYNJ2(4), SYT1(3)	6288611	39	35	39	11	8	12	3	2	13	1	0.389	1.000	1.000
401	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(1), GCLC(1), GCLM(1), GPX7(1), GSR(3), GSTA5(1), GSTK1(2), GSTM3(1), GSTM5(1), GSTP1(1), IDH1(1), IDH2(4), MGST3(2), OPLAH(3)	6208281	23	23	23	6	5	10	1	4	3	0	0.350	1.000	1.000
402	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(5), AKT1(4), GNAI1(1), GNGT1(1), ITGAV(5), ITGB3(2), MAPK1(1), PDGFA(2), PDGFRA(4), PIK3CA(21), PIK3R1(5), PLCB1(3), PRKCA(1), PTK2(1), RAC1(1), SMPD1(2)	7472692	59	45	51	15	10	21	8	7	13	0	0.239	1.000	1.000
403	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	CASP2(2), CHUK(5), CRADD(1), IKBKB(2), JUN(1), MAP2K4(3), MAP3K1(8), MAP4K2(4), MAPK14(1), MAPK8(1), NFKB1(2), RIPK1(2), TANK(3), TRAF2(1)	6736502	36	32	36	10	6	10	6	5	9	0	0.514	1.000	1.000
404	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	ALOX12(2), ALOX12B(4), ALOX15(2), ALOX15B(2), ALOX5(4), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2E1(2), CYP2J2(1), CYP2U1(2), CYP4A22(2), CYP4F2(4), CYP4F3(1), DHRS4(2), EPHX2(2), GPX7(1), LTA4H(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(2), PTGIS(2), PTGS1(2), TBXAS1(2)	11142820	61	45	61	13	22	22	4	4	9	0	0.0343	1.000	1.000
405	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), FUCA2(3), GLB1(2), LCT(8), MAN2B1(4), MAN2B2(6), MAN2C1(4), MANBA(1), NEU1(1), NEU2(2), NEU4(4)	5545815	36	30	36	11	7	18	5	1	5	0	0.395	1.000	1.000
406	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREBBP(13), EP300(12), NCOA3(3), PRKAR1B(2), PRKAR2B(3)	5579274	35	28	35	11	5	13	3	1	13	0	0.664	1.000	1.000
407	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(2), CCND1(1), CREBBP(13), EP300(12), ERCC3(1), ESR1(6), GRIP1(4), GTF2E1(1), GTF2F1(5), HDAC1(1), HDAC3(3), HDAC4(12), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(12), NR0B1(1), NRIP1(3), PELP1(3), POLR2A(3), TBP(2)	12822425	98	65	93	24	28	32	8	6	24	0	0.0851	1.000	1.000
408	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), CALM3(1), ELK1(2), FOS(1), GNAI1(1), GNAQ(1), GNAS(16), GNGT1(1), HRAS(1), JUN(1), MAP2K1(2), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), RAF1(2), SYT1(3)	9508983	70	57	70	17	23	22	7	4	14	0	0.118	1.000	1.000
409	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(16), GNGT1(1), PPP2CA(1), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKAG1(1), PRKAG2(1), PRKAR1B(2), PRKAR2B(3)	4211293	37	35	37	11	11	11	5	3	7	0	0.523	1.000	1.000
410	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(1), CHUK(5), ELK1(2), FOS(1), IKBKB(2), IRAK1(2), JUN(1), MAP2K4(3), MAP3K1(8), MAP3K7(3), MAPK14(1), MAPK8(1), NFKB1(2), PPARA(1), TLR10(3), TLR2(5), TLR3(1), TLR4(6), TLR6(2), TLR7(1), TOLLIP(1), TRAF6(1)	9938613	53	46	52	13	5	14	13	7	14	0	0.341	1.000	1.000
411	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(1), AGTR2(2), CMA1(1), COL4A1(2), COL4A2(6), COL4A3(4), COL4A4(6), COL4A5(7), COL4A6(4), REN(2)	7056935	38	33	38	11	8	18	3	4	5	0	0.511	1.000	1.000
412	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(3), ATG7(4), BECN1(1), IFNA16(1), IFNA2(1), IFNA7(1), IFNG(1), PIK3C3(1), PRKAA1(2), PRKAA2(1), ULK1(3), ULK2(2), ULK3(3)	5863242	25	23	25	9	4	10	4	3	4	0	0.746	1.000	1.000
413	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(4), AKT2(1), AKT3(2), BTK(1), FYN(1), GAB2(2), HRAS(1), IL3(2), INPP5D(4), KRAS(3), LCP2(4), LYN(2), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK9(2), MS4A2(1), NRAS(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCG1(5), PLCG2(3), PRKCA(1), PRKCD(2), PRKCE(2), RAC1(1), RAF1(2), SOS1(3), SOS2(1), SYK(2), VAV1(8), VAV2(1), VAV3(2)	19975267	133	91	123	26	32	55	16	11	19	0	0.00309	1.000	1.000
414	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(2), ALOX15(2), ALOX5(4), CYP4F2(4), CYP4F3(1), EPX(2), LPO(3), LTA4H(1), MPO(3), PLA2G2E(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PRDX1(2), PRDX2(1), PRDX6(3), PTGDS(2), PTGES2(2), PTGIS(2), PTGS1(2), TBXAS1(2), TPO(8)	7948482	52	43	52	14	20	15	5	3	9	0	0.156	1.000	1.000
415	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(3), ACAT2(1), ACOT11(1), ACYP1(1), DHRS1(1), DHRS3(2), DHRSX(1), ECHS1(1), EHHADH(1), ESCO1(3), ESCO2(1), FN3K(2), GCDH(1), HADHA(2), SH3GLB1(2), YOD1(1)	6940979	24	23	24	7	3	12	2	0	7	0	0.627	1.000	1.000
416	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(1), ANXA4(2), ANXA5(3), ANXA6(1), CYP11A1(2), EDNRA(1), EDNRB(3), HSD11B1(1), HSD11B2(1), PLA2G4A(1), PRL(2), PTGDS(2), PTGER2(1), PTGER4(3), PTGFR(1), PTGIR(2), PTGIS(2), PTGS1(2), TBXAS1(2)	5619371	33	27	33	10	9	11	4	4	5	0	0.459	1.000	1.000
417	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(2), F11(4), F12(2), F13B(3), F2(4), F5(4), F7(1), F8(7), F9(1), FGA(4), FGB(3), FGG(1), LPA(10), PLAT(1), PLG(3), SERPINB2(2), SERPINF2(2), VWF(9)	9584006	63	49	62	16	14	21	10	3	15	0	0.272	1.000	1.000
418	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(4), AKT2(1), AKT3(2), CASP9(1), HRAS(1), KDR(5), KRAS(3), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK11(1), MAPK14(1), MAPKAPK2(1), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NOS3(5), NRAS(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCG1(5), PLCG2(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCA(1), PRKCG(2), PTK2(1), PXN(3), RAC1(1), RAF1(2), SH2D2A(1), SPHK2(3)	20043983	134	85	125	25	32	57	13	13	19	0	0.00111	1.000	1.000
419	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(6), EEF1A2(1), EEF1G(1), EEF2(5), EEF2K(4), EIF1AY(1), EIF2AK1(2), EIF2AK3(1), EIF2B1(4), EIF2B2(1), EIF2B4(1), EIF2B5(2), EIF2S1(1), EIF2S3(2), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4EBP2(3), EIF4G1(6), EIF4G3(4), EIF5B(6), PABPC1(2), PABPC3(5), PAIP1(1)	12225376	63	50	60	14	9	22	7	9	16	0	0.162	1.000	1.000
420	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(6), COL4A3(4), COL4A4(6), COL4A5(7), COL4A6(4), P4HB(2), SLC23A1(1), SLC23A2(4), SLC2A1(1), SLC2A3(1)	7089803	38	31	38	12	7	17	4	5	5	0	0.528	1.000	1.000
421	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(6), EGF(4), EGFR(5), HRAS(1), MAP2K1(2), MAPK1(1), PTPRB(2), RAF1(2), RASA1(9), SOS1(3), SPRY4(2)	6892034	37	30	37	11	6	15	5	6	5	0	0.523	1.000	1.000
422	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(4), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1C4(2), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), CYP27A1(2), SOAT2(1)	6362072	40	33	40	14	13	10	5	3	9	0	0.549	1.000	1.000
423	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), AMD1(1), BHMT(3), DNMT1(2), DNMT3A(4), DNMT3B(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), MTAP(2), MTFMT(1), MTR(7), SRM(3), TAT(2)	5743274	35	28	35	11	8	11	2	6	8	0	0.470	1.000	1.000
424	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), ALAS2(2), AMT(1), AOC2(4), AOC3(5), BHMT(3), CHDH(1), CHKB(1), DAO(1), DLD(4), DMGDH(1), GAMT(1), GARS(3), GATM(2), GLDC(2), HSD3B7(2), MAOA(2), MAOB(3), PHGDH(1), PIPOX(1), PISD(1), PSAT1(3), PSPH(2), RDH13(1), SARDH(2), SARS(2), SARS2(1), SDS(1), SHMT1(2), SHMT2(2), TARS(6), TARS2(2)	12051986	67	49	67	16	15	30	6	7	9	0	0.0674	1.000	1.000
425	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(1), ACP5(1), ACPP(3), ALPL(1), ALPP(5), CYP19A1(1), CYP1A1(3), CYP1A2(1), CYP2A13(4), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(1), CYP3A5(2), CYP3A7(1), CYP4B1(1), CYP51A1(4), PON1(1)	8200350	47	39	47	13	10	18	4	6	9	0	0.232	1.000	1.000
426	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(4), AKT2(1), AKT3(2), ANKRD6(2), APC(15), AXIN1(2), AXIN2(2), CER1(1), CSNK1A1(2), CTNNB1(9), DACT1(2), DKK2(3), DKK3(1), DKK4(2), FRAT1(1), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(8), MVP(3), NKD2(5), PSEN1(2), PTPRA(4), SENP2(3), SFRP1(2), TSHB(2), WIF1(2)	11232811	88	65	85	23	20	26	11	9	21	1	0.239	1.000	1.000
427	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ACAT1(3), ACAT2(1), AFMID(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), AOC2(4), AOC3(5), AOX1(4), ASMT(4), CARM1(2), CYP1A1(3), CYP1A2(1), DDC(2), ECHS1(1), EHHADH(1), GCDH(1), HADH(1), HADHA(2), HEMK1(1), HSD17B4(4), KMO(1), KYNU(2), LCMT1(1), LNX1(2), MAOA(2), MAOB(3), METTL2B(1), NFX1(3), OGDH(2), OGDHL(6), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WARS(1), WARS2(2)	16676454	91	65	91	20	29	36	2	10	14	0	0.0296	1.000	1.000
428	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(5), CA1(3), CA14(2), CA3(1), CA4(2), CA5A(1), CA6(1), CA7(1), CPS1(11), GLS(2), GLUD1(1), GLUL(2), HAL(1)	5202756	34	27	34	11	1	12	7	7	7	0	0.653	1.000	1.000
429	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), ALAS2(2), AMT(1), AOC2(4), AOC3(5), ATP6V0C(1), BHMT(3), CHDH(1), CHKB(1), CPT1B(6), DAO(1), DLD(4), DMGDH(1), GAMT(1), GARS(3), GATM(2), GLDC(2), MAOA(2), MAOB(3), PISD(1), PLCB2(1), PLCG1(5), PLCG2(3), PSPH(2), SARDH(2), SARS(2), SHMT1(2), SHMT2(2), TARS(6)	11752292	71	53	70	17	18	31	6	5	11	0	0.0608	1.000	1.000
430	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(4), BST1(1), CD38(2), ENPP1(5), ENPP3(4), NADK(2), NADSYN1(2), NMNAT1(2), NMNAT2(2), NNMT(2), NNT(2), NT5C1A(1), NT5C1B(2), NT5M(1), NUDT12(1)	5925817	33	29	33	11	3	17	0	6	7	0	0.648	1.000	1.000
431	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP5(1), BMP6(2), BMP7(2), BMP8B(2), BTRC(3), CSNK1A1(2), CSNK1A1L(1), CSNK1D(1), CSNK1E(1), CSNK1G2(1), GAS1(2), GLI1(5), GLI2(5), GLI3(9), GSK3B(3), HHIP(4), IHH(2), LRP2(20), PRKACA(3), PTCH1(13), PTCH2(4), SMO(4), STK36(3), SUFU(2), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT3A(1), WNT5B(2), WNT7B(3), WNT8B(1), WNT9A(2), WNT9B(2), ZIC2(3)	16379553	116	73	115	28	30	34	12	15	25	0	0.0834	1.000	1.000
432	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(6), CALM3(1), GNAQ(1), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK14(1), MAPK8(1), PAK1(2), PLCG1(5), PRKCA(1), PTK2B(4), RAC1(1), RAF1(2), SOS1(3), SYT1(3)	7874496	50	46	50	15	14	14	5	7	10	0	0.431	1.000	1.000
433	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(4), BRAF(4), CREB5(2), CREBBP(13), DAG1(1), EGR1(2), EGR4(1), ELK1(2), FRS2(1), GNAQ(1), JUN(1), MAP1B(13), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), NTRK1(5), PIK3C2G(4), PIK3CA(21), PIK3CD(5), PIK3R1(5), PTPN11(2), TERF2IP(1), TH(3)	14127862	106	75	98	29	21	37	10	14	24	0	0.201	1.000	1.000
434	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(4), ACADL(5), ACADS(2), ACADSB(1), ACADVL(2), ACAT1(3), ACAT2(1), ACOX1(4), ACOX3(1), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(1), ACSL6(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CPT1A(2), CPT1B(6), CPT1C(2), CPT2(1), CYP4A22(2), ECHS1(1), EHHADH(1), GCDH(1), HADH(1), HADHA(2), HSD17B4(4)	13373244	74	57	73	19	21	32	2	3	16	0	0.150	1.000	1.000
435	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(4), CREB5(2), DUSP10(3), EEF2K(4), ELK1(2), IL1R1(1), MAP2K4(3), MAP3K10(4), MAP3K4(6), MAP3K5(8), MAP3K7(3), MAPK1(1), MAPK11(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(1), MKNK2(2), MYEF2(2), NFKB1(2), NR2C2(4), TRAF6(1)	9368323	58	40	56	16	20	17	6	5	10	0	0.206	1.000	1.000
436	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(2), ACTG1(1), ARHGEF2(5), ARPC5(1), CD14(1), CDH1(1), CTNNB1(9), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(1), KRT18(2), NCK1(1), NCK2(2), NCL(5), OCLN(2), PRKCA(1), RHOA(3), ROCK1(2), ROCK2(4), TLR4(6), TUBA1A(2), TUBA1C(1), TUBA3C(7), TUBA3D(4), TUBA3E(1), TUBA8(5), TUBB(1), TUBB1(3), TUBB2A(3), TUBB2B(1), TUBB3(2), TUBB6(2), TUBB8(1), WASL(2), YWHAQ(1), YWHAZ(1)	14498774	92	62	91	22	20	30	25	6	11	0	0.0659	1.000	1.000
437	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(2), ACTG1(1), ARHGEF2(5), ARPC5(1), CD14(1), CDH1(1), CTNNB1(9), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(1), KRT18(2), NCK1(1), NCK2(2), NCL(5), OCLN(2), PRKCA(1), RHOA(3), ROCK1(2), ROCK2(4), TLR4(6), TUBA1A(2), TUBA1C(1), TUBA3C(7), TUBA3D(4), TUBA3E(1), TUBA8(5), TUBB(1), TUBB1(3), TUBB2A(3), TUBB2B(1), TUBB3(2), TUBB6(2), TUBB8(1), WASL(2), YWHAQ(1), YWHAZ(1)	14498774	92	62	91	22	20	30	25	6	11	0	0.0659	1.000	1.000
438	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(5), FADD(1), IKBKB(2), IL1R1(1), IRAK1(2), MAP3K1(8), MAP3K7(3), NFKB1(2), RIPK1(2), TLR4(6), TNFAIP3(5), TNFRSF1B(1), TRAF6(1)	6681831	39	33	38	13	8	7	9	6	9	0	0.709	1.000	1.000
439	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), ALDOC(4), DERA(2), FBP2(2), H6PD(1), PFKL(1), PFKM(4), PFKP(2), PGD(1), PGLS(2), PGM1(1), PRPS1(1), PRPS2(2), RBKS(1), RPE(1), RPIA(1), TKT(1), TKTL1(1)	6668314	30	27	30	10	6	13	2	6	3	0	0.519	1.000	1.000
440	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS2(2), BLVRA(3), CP(3), CPOX(1), EARS2(1), EPRS(3), FECH(1), FTH1(2), FTMT(2), GUSB(2), HCCS(2), HMBS(1), HMOX1(1), MMAB(1), PPOX(4), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1), UROD(1), UROS(1)	11416315	49	39	49	12	12	18	6	6	7	0	0.181	1.000	1.000
441	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(1), ALG11(1), ALG12(3), ALG13(1), ALG14(1), ALG5(2), ALG6(2), ALG9(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), DDOST(1), FUT8(2), GANAB(2), MAN1A1(2), MAN1A2(2), MAN1B1(2), MAN1C1(1), MGAT1(1), MGAT2(1), MGAT3(3), MGAT4A(2), MGAT4B(2), MGAT5(3), MGAT5B(8), RFT1(1), RPN1(3), RPN2(3), STT3B(5)	11728759	66	51	66	18	11	24	10	6	15	0	0.316	1.000	1.000
442	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(4), EXT2(1), EXTL3(3), GLCE(3), HS2ST1(1), HS3ST1(4), HS3ST3A1(2), HS3ST5(2), HS6ST1(2), HS6ST2(2), NDST1(5), NDST2(5), NDST3(5), NDST4(6)	5708978	45	38	45	15	12	14	8	7	4	0	0.467	1.000	1.000
443	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP2(2), CASP8(6), CRADD(1), DFFA(1), DFFB(2), FADD(1), JUN(1), LMNA(2), LMNB1(1), LMNB2(5), MADD(7), MAP2K4(3), MAP3K1(8), MAP3K7(3), MAPK8(1), PAK1(2), PAK2(1), PRKDC(14), RB1(8), RIPK1(2), SPTAN1(8), TRAF2(1)	10935795	80	53	79	22	13	19	8	14	26	0	0.588	1.000	1.000
444	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(2), FUCA1(1), FUCA2(3), GALNS(1), GBA(2), GLB1(2), GNS(2), GUSB(2), HGSNAT(3), HPSE2(3), HYAL2(2), IDUA(1), LCT(8), MAN2B1(4), MAN2B2(6), MAN2C1(4), MANBA(1), NAGLU(3), NEU1(1), NEU2(2), NEU4(4), SPAM1(1)	9599067	58	46	58	17	11	25	7	6	9	0	0.285	1.000	1.000
445	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(4), AP2A1(1), ARF1(1), BTK(1), EEA1(2), GRASP(1), GSK3A(2), GSK3B(3), LYN(2), PFKL(1), PFKM(4), PFKP(2), PLCG1(5), PRKCE(2), PRKCZ(2), RAB5A(1), RAC1(1), VAV2(1)	7053156	36	31	36	11	12	11	6	1	6	0	0.405	1.000	1.000
446	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALT2(2), B3GALT4(1), B3GNT1(4), B3GNT2(1), B3GNT5(1), B4GALNT1(3), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), B4GALT6(3), FUT1(1), FUT3(2), FUT4(1), FUT5(1), FUT6(2), FUT7(1), FUT9(4), PIGB(1), PIGG(1), PIGK(2), PIGN(6), PIGO(3), PIGQ(5), PIGS(4), PIGT(4), PIGZ(1), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(1), ST6GALNAC5(2), ST6GALNAC6(1), UGCG(1)	13370806	75	62	75	20	19	26	10	13	7	0	0.145	1.000	1.000
447	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(4), CALR(2), CANX(1), CD74(1), CIITA(3), HLA-A(1), HLA-B(7), HLA-C(4), HLA-DMB(3), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA2(5), HLA-DRB1(1), HLA-DRB5(2), HLA-E(1), HLA-G(2), HSP90AA1(2), HSP90AB1(3), IFI30(1), IFNA16(1), IFNA2(1), IFNA7(1), KIR2DL3(5), KIR3DL1(3), KIR3DL2(2), KLRC3(1), KLRC4(1), KLRD1(2), NFYA(1), NFYB(2), NFYC(1), PDIA3(2), PSME1(1), PSME2(3), RFX5(5), RFXANK(1), RFXAP(2), TAP2(1), TAPBP(1)	12928229	82	54	82	23	14	24	13	9	22	0	0.401	1.000	1.000
448	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(8), DIAPH1(2), FYN(1), GSN(3), HRAS(1), ITGA1(3), ITGB1(1), MAP2K1(2), MAPK1(1), MYLK(6), PIK3CA(21), PIK3R1(5), PTK2(1), PXN(3), RAF1(2), ROCK1(2), TLN1(7)	10280703	69	58	61	20	10	31	14	7	7	0	0.337	1.000	1.000
449	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR3(1), AKT1(4), AKT2(1), AKT3(2), ANGPTL2(3), ARHGEF11(1), BTK(1), CFL1(1), GDI1(1), GDI2(1), INPPL1(2), ITPR1(6), ITPR2(8), ITPR3(2), LIMK1(1), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PIK3CA(21), PIK3CD(5), PIK3CG(1), PIK3R1(5), PITX2(1), PPP1R13B(4), PTEN(7), RACGAP1(1), RHO(1), ROCK1(2), ROCK2(4), SAG(1), WASF1(3), WASL(2)	19353007	117	82	109	27	20	39	17	22	18	1	0.0687	1.000	1.000
450	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT4(3), AGPS(4), CDS1(1), CDS2(1), CHAT(8), CHKB(1), CPT1B(6), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKZ(2), ETNK1(2), GNPAT(1), GPD2(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(2), PCYT1B(3), PISD(1), PLA2G2E(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCB2(1), PLCG1(5), PLCG2(3), PPAP2A(2), PPAP2B(3)	14001037	80	60	79	21	28	28	5	6	13	0	0.0944	1.000	1.000
451	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(3), CMAS(1), CTBS(1), CYB5R1(1), GFPT1(2), GFPT2(3), GNE(1), HK1(1), HK2(3), HK3(2), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), NAGK(2), NANS(3), NPL(1), RENBP(2), UAP1(1)	7946896	35	27	34	11	6	16	2	3	8	0	0.468	1.000	1.000
452	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(4), AKT2(1), AKT3(2), BCR(4), BLNK(3), BTK(1), CSK(2), DAG1(1), EPHB2(4), ITPKB(6), LYN(2), MAP2K1(2), MAP2K2(3), MAPK1(1), NFAT5(4), NFKB1(2), NFKB2(2), PIK3CA(21), PIK3CD(5), PIK3R1(5), PLCG2(3), PPP1R13B(4), RAF1(2), SERPINA4(4), SOS1(3), SOS2(1), SYK(2), VAV1(8)	14688814	102	77	94	26	22	42	7	12	19	0	0.0868	1.000	1.000
453	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(5), CDC7(1), CDK2(1), CDT1(1), DIAPH2(8), MCM10(2), MCM2(2), MCM3(3), MCM4(1), MCM5(1), MCM6(2), MCM7(1), NACA(7), POLA2(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), PRIM1(4), RFC1(5), RFC3(3), RFC4(1), RFC5(1), RPA1(3), RPA4(3)	13848527	74	52	74	19	10	29	9	14	12	0	0.254	1.000	1.000
454	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(1), ADAM17(3), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), CCL5(1), CHUK(5), CSK(2), CXCL1(1), EGFR(5), IKBKB(2), JAM3(1), JUN(1), LYN(2), MAP2K4(3), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK9(2), MET(4), NFKB1(2), NFKB2(2), NOD1(4), PAK1(2), PLCG1(5), PLCG2(3), PTPN11(2), PTPRZ1(8), RAC1(1), TCIRG1(1), TJP1(6)	19415392	93	70	93	21	18	30	13	15	17	0	0.100	1.000	1.000
455	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(2), ACVR1C(2), AKT1(4), AKT2(1), AKT3(2), ARRB1(5), ARRB2(1), ATF4(2), BDNF(3), BRAF(4), CACNA1A(13), CACNA1B(6), CACNA1C(14), CACNA1D(7), CACNA1E(15), CACNA1F(7), CACNA1G(7), CACNA1H(10), CACNA1I(8), CACNA1S(5), CACNA2D1(5), CACNA2D2(2), CACNA2D3(8), CACNA2D4(6), CACNB1(2), CACNB2(1), CACNG2(1), CACNG3(1), CACNG4(2), CACNG5(4), CACNG6(2), CACNG8(2), CD14(1), CDC25B(2), CHUK(5), CRK(1), DAXX(3), DUSP10(3), DUSP4(1), DUSP5(1), DUSP6(1), DUSP7(2), DUSP9(2), ECSIT(2), EGF(4), EGFR(5), ELK1(2), ELK4(1), FASLG(1), FGF1(2), FGF13(4), FGF14(5), FGF23(4), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(2), FGF8(1), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(1), FGFR4(4), FLNA(3), FLNB(4), FLNC(10), FOS(1), GADD45B(2), GNA12(1), HRAS(1), IKBKB(2), IL1B(3), IL1R1(1), IL1R2(2), JUN(1), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP2K5(2), MAP3K1(8), MAP3K10(4), MAP3K12(2), MAP3K13(2), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAP3K5(8), MAP3K6(4), MAP3K7(3), MAP4K2(4), MAP4K3(3), MAP4K4(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK7(1), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MAPKAPK2(1), MAPKAPK5(2), MAPT(1), MAX(1), MEF2C(2), MKNK1(1), MKNK2(2), MRAS(1), NF1(8), NFATC2(6), NFATC4(4), NFKB1(2), NFKB2(2), NLK(4), NR4A1(1), NRAS(1), NTRK1(5), NTRK2(6), PAK1(2), PAK2(1), PDGFA(2), PDGFB(2), PDGFRA(4), PDGFRB(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PPP5C(2), PRKACA(3), PRKCA(1), PRKCG(2), PTPN7(1), PTPRR(6), RAC1(1), RAF1(2), RAP1A(1), RAPGEF2(4), RASA1(9), RASA2(2), RASGRF1(9), RASGRF2(5), RASGRP1(4), RASGRP2(1), RASGRP3(2), RASGRP4(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(4), RPS6KA6(4), SOS1(3), SOS2(1), STK4(2), STMN1(1), TAOK1(3), TAOK2(3), TAOK3(2), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15), TP53(174), TRAF2(1), TRAF6(1), ZAK(4)	81492956	702	180	625	157	195	180	75	71	177	4	2.58e-07	1.000	1.000
456	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(2), ADORA1(2), ADORA2A(5), ADORA2B(2), ADORA3(1), ADRA1A(7), ADRA1B(1), ADRA2A(3), ADRA2B(1), ADRA2C(2), ADRB1(1), ADRB2(1), AGTR2(2), AVPR1A(3), AVPR2(1), C3AR1(3), C5AR1(1), CALCRL(1), CCKAR(1), CCKBR(3), CHRM1(2), CHRM2(8), CHRM3(5), CHRM4(2), CHRM5(1), CNR1(3), CNR2(1), CRHR1(2), CYSLTR1(1), DRD1(3), DRD2(4), DRD3(2), DRD4(1), EDNRA(1), EDNRB(3), F2(4), F2R(4), F2RL1(1), F2RL2(1), F2RL3(2), FPR1(1), FSHR(6), GABBR1(2), GABBR2(3), GABRA1(7), GABRA2(8), GABRA3(1), GABRA4(3), GABRA5(4), GABRA6(7), GABRB1(7), GABRB2(1), GABRB3(4), GABRE(3), GABRG1(5), GABRG2(4), GABRG3(2), GABRP(1), GABRR2(1), GALR1(2), GALR2(3), GALR3(1), GH1(1), GH2(2), GHR(2), GHRHR(2), GHSR(2), GIPR(1), GLP1R(1), GLP2R(2), GLRA1(1), GLRA2(2), GLRA3(1), GLRB(6), GPR156(2), GPR50(1), GPR63(3), GPR83(5), GRIA1(9), GRIA2(8), GRIA3(5), GRIA4(10), GRID1(7), GRID2(7), GRIK1(4), GRIK2(4), GRIK3(7), GRIK4(10), GRIK5(2), GRIN2A(3), GRIN2B(5), GRIN2C(3), GRIN2D(2), GRIN3A(3), GRIN3B(3), GRM1(9), GRM2(3), GRM3(9), GRM4(7), GRM5(5), GRM6(3), GRM7(3), GRM8(11), GRPR(1), GZMA(1), HCRTR2(6), HRH1(2), HRH2(3), HRH3(1), HRH4(2), HTR1A(1), HTR1B(1), HTR1D(4), HTR1E(5), HTR1F(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3), LEPR(4), LHCGR(6), MAS1(1), MC1R(2), MC2R(1), MC3R(1), MC4R(5), MCHR1(2), MCHR2(3), MLNR(1), MTNR1A(1), MTNR1B(2), NMUR1(1), NMUR2(1), NPBWR1(6), NPBWR2(5), NPFFR1(1), NPFFR2(2), NPY1R(1), NPY2R(1), NPY5R(1), NR3C1(1), NTSR1(1), NTSR2(2), OPRD1(1), OPRK1(2), OPRL1(4), OPRM1(1), OXTR(1), P2RX1(1), P2RX2(1), P2RX4(2), P2RX7(2), P2RY1(2), P2RY10(3), P2RY11(2), P2RY13(3), P2RY14(1), P2RY4(1), P2RY6(2), P2RY8(1), PARD3(7), PRL(2), PRLHR(2), PRLR(3), PRSS1(3), PRSS3(1), PTGER2(1), PTGER3(1), PTGER4(3), PTGFR(1), PTGIR(2), PTH2R(2), RXFP1(5), RXFP2(6), SSTR1(2), SSTR3(2), SSTR4(2), SSTR5(1), TAAR2(1), TAAR5(2), TAAR6(1), TAAR8(1), TACR3(3), TBXA2R(2), THRA(6), THRB(1), TRPV1(3), TSHB(2), TSHR(3), TSPO(1)	59829595	539	172	538	178	139	175	80	58	87	0	0.0495	1.000	1.000
457	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(2), ACTG1(1), ACTN1(1), ACTN2(8), ACTN4(4), AKT1(4), AKT2(1), AKT3(2), ARHGAP5(8), BCAR1(6), BIRC2(1), BIRC3(2), BRAF(4), CAPN2(1), CAV1(1), CCND1(1), COL11A1(20), COL11A2(8), COL1A1(2), COL1A2(5), COL2A1(8), COL3A1(7), COL4A1(2), COL4A2(6), COL4A4(6), COL4A6(4), COL5A1(8), COL5A2(6), COL5A3(1), COL6A1(8), COL6A2(7), COL6A3(13), COL6A6(11), COMP(2), CRK(1), CTNNB1(9), DIAPH1(2), DOCK1(9), EGF(4), EGFR(5), ELK1(2), ERBB2(12), FARP2(3), FLNA(3), FLNB(4), FLNC(10), FLT1(7), FN1(7), FYN(1), GSK3B(3), HGF(2), HRAS(1), IBSP(5), IGF1(1), IGF1R(4), ILK(2), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAV(5), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), JUN(1), KDR(5), LAMA1(25), LAMA2(9), LAMA3(8), LAMA4(7), LAMA5(14), LAMB1(5), LAMB2(3), LAMB4(8), LAMC1(5), LAMC3(4), MAP2K1(2), MAPK1(1), MAPK10(3), MAPK8(1), MAPK9(2), MET(4), MYL7(2), MYL9(1), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PARVA(2), PARVB(1), PARVG(1), PDGFA(2), PDGFB(2), PDGFC(3), PDGFD(1), PDGFRA(4), PDGFRB(4), PGF(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PRKCA(1), PRKCG(2), PTEN(7), PTK2(1), PXN(3), RAC1(1), RAF1(2), RAP1A(1), RAPGEF1(4), RELN(17), RHOA(3), ROCK1(2), ROCK2(4), SHC4(3), SOS1(3), SOS2(1), THBS1(2), THBS2(6), THBS3(2), THBS4(2), TLN1(7), TLN2(11), TNC(8), TNN(7), TNR(10), TNXB(14), VAV1(8), VAV2(1), VAV3(2), VCL(8), VEGFC(5), VWF(9), ZYX(1)	103525747	700	171	682	180	186	242	85	64	122	1	6.88e-05	1.000	1.000
458	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY7(5), ADCY8(11), ADCY9(6), ADORA2A(5), ADORA2B(2), ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRB1(1), ADRB2(1), ATP2A1(4), ATP2A2(5), ATP2A3(3), ATP2B1(5), ATP2B2(5), ATP2B3(3), ATP2B4(7), AVPR1A(3), BST1(1), CACNA1A(13), CACNA1B(6), CACNA1C(14), CACNA1D(7), CACNA1E(15), CACNA1F(7), CACNA1G(7), CACNA1H(10), CACNA1I(8), CACNA1S(5), CALM3(1), CAMK2A(3), CAMK2B(2), CCKAR(1), CCKBR(3), CD38(2), CHRM1(2), CHRM2(8), CHRM3(5), CHRM5(1), CHRNA7(1), CYSLTR1(1), DRD1(3), EDNRA(1), EDNRB(3), EGFR(5), ERBB2(12), ERBB3(6), ERBB4(17), F2R(4), GNA14(1), GNA15(2), GNAL(2), GNAQ(1), GNAS(16), GRIN2A(3), GRIN2C(3), GRIN2D(2), GRM1(9), GRM5(5), GRPR(1), HRH1(2), HRH2(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), LHCGR(6), MYLK(6), MYLK2(1), NOS1(6), NOS3(5), NTSR1(1), OXTR(1), P2RX1(1), P2RX2(1), P2RX4(2), P2RX7(2), PDE1A(3), PDE1B(3), PDE1C(3), PDGFRA(4), PDGFRB(4), PHKA1(5), PHKA2(3), PHKB(4), PHKG1(2), PHKG2(2), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCD3(2), PLCD4(2), PLCE1(10), PLCG1(5), PLCG2(3), PLCZ1(4), PPID(1), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKACA(3), PRKCA(1), PRKCG(2), PTGER3(1), PTGFR(1), PTK2B(4), RYR1(13), RYR2(35), RYR3(28), SLC25A4(2), SLC25A5(2), SLC8A1(7), SLC8A2(4), SLC8A3(1), SPHK2(3), TACR3(3), TBXA2R(2), TNNC1(1), TRPC1(5), VDAC1(2), VDAC2(1)	76355780	580	162	571	171	158	210	69	53	90	0	0.00133	1.000	1.000
459	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	200	ABI2(4), ACTN1(1), ACTN2(8), ACTN4(4), APC(15), ARAF(3), ARHGEF1(3), ARHGEF12(4), ARHGEF4(1), ARHGEF6(2), ARHGEF7(3), ARPC5(1), BAIAP2(2), BCAR1(6), BRAF(4), CD14(1), CFL1(1), CHRM1(2), CHRM2(8), CHRM3(5), CHRM4(2), CHRM5(1), CRK(1), CSK(2), CYFIP1(5), CYFIP2(8), DIAPH1(2), DIAPH2(8), DIAPH3(6), DOCK1(9), EGF(4), EGFR(5), EZR(1), F2(4), F2R(4), FGD3(2), FGF1(2), FGF13(4), FGF14(5), FGF23(4), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(2), FGF8(1), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(1), FGFR4(4), FN1(7), GNA12(1), GNA13(3), GSN(3), HRAS(1), IQGAP1(7), IQGAP2(2), IQGAP3(5), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAD(6), ITGAE(3), ITGAL(6), ITGAM(3), ITGAV(5), ITGAX(2), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), KRAS(3), LIMK1(1), LIMK2(3), MAP2K1(2), MAP2K2(3), MAPK1(1), MRAS(1), MSN(7), MYH10(9), MYH14(10), MYH9(2), MYL7(2), MYL9(1), MYLK(6), MYLK2(1), NCKAP1(4), NCKAP1L(3), NRAS(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PDGFA(2), PDGFB(2), PDGFRA(4), PDGFRB(4), PFN4(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PIP4K2A(1), PIP4K2B(5), PIP5K1A(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PPP1R12B(1), PTK2(1), PXN(3), RAC1(1), RAF1(2), RDX(6), RHOA(3), ROCK1(2), ROCK2(4), SCIN(4), SLC9A1(2), SOS1(3), SOS2(1), SSH1(1), SSH2(7), SSH3(1), TIAM1(6), TIAM2(4), VAV1(8), VAV2(1), VAV3(2), VCL(8), WASF1(3), WASF2(3), WASL(2)	76890559	522	162	505	127	129	173	76	52	92	0	8.98e-05	1.000	1.000
460	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(2), ACTG1(1), COL11A1(20), COL11A2(8), COL17A1(3), COL1A1(2), COL1A2(5), COL2A1(8), COL3A1(7), COL4A1(2), COL4A2(6), COL4A4(6), COL4A6(4), COL5A1(8), COL5A2(6), COL5A3(1), COL6A1(8), COL6A2(7), COL6A3(13), COL6A6(11), COMP(2), DSC1(1), DSC2(1), DSC3(1), DSG1(7), DSG2(6), DSG3(4), DSG4(3), FN1(7), GJA1(1), GJA10(1), GJA5(3), GJA8(2), GJB4(1), GJB5(1), GJB6(2), GJB7(1), GJC1(1), GJC3(1), GJD2(1), GJD4(1), IBSP(5), ITGA6(7), ITGB4(5), KRT1(5), KRT10(4), KRT12(5), KRT13(1), KRT14(1), KRT15(3), KRT17(1), KRT18(2), KRT19(1), KRT2(1), KRT20(2), KRT23(7), KRT24(4), KRT25(3), KRT27(3), KRT28(1), KRT3(1), KRT31(2), KRT33A(2), KRT33B(2), KRT34(1), KRT35(1), KRT36(1), KRT37(2), KRT38(2), KRT39(1), KRT5(1), KRT6A(5), KRT6B(4), KRT6C(2), KRT72(3), KRT73(3), KRT74(1), KRT76(1), KRT77(2), KRT78(1), KRT79(2), KRT8(3), KRT81(2), KRT84(2), KRT85(2), KRT9(4), LAMA1(25), LAMA2(9), LAMA3(8), LAMA4(7), LAMA5(14), LAMB1(5), LAMB2(3), LAMB4(8), LAMC1(5), LAMC3(4), LMNA(2), LMNB1(1), LMNB2(5), NES(8), PRPH(2), RELN(17), THBS1(2), THBS2(6), THBS3(2), THBS4(2), TNC(8), TNN(7), TNR(10), TNXB(14), VIM(2), VWF(9)	69517679	475	155	471	137	136	158	54	55	72	0	0.0172	1.000	1.000
461	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRB1(1), ADRB2(1), ANXA6(1), ARRB1(5), ARRB2(1), ATP1A4(3), ATP1B1(1), ATP2A2(5), ATP2A3(3), ATP2B1(5), ATP2B2(5), ATP2B3(3), CACNA1A(13), CACNA1B(6), CACNA1C(14), CACNA1D(7), CACNA1E(15), CACNA1S(5), CACNB1(2), CALM3(1), CALR(2), CAMK1(1), CAMK2A(3), CAMK2B(2), CASQ1(1), CASQ2(1), CHRM1(2), CHRM2(8), CHRM3(5), CHRM4(2), CHRM5(1), GJA1(1), GJA5(3), GJB4(1), GJB5(1), GJB6(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAZ(2), GNB2(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(2), GRK5(3), ITPR1(6), ITPR2(8), ITPR3(2), KCNB1(1), KCNJ5(2), MIB1(1), NME7(3), PKIA(1), PLCB3(4), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(7), RGS11(1), RGS14(1), RGS17(1), RGS18(1), RGS19(1), RGS2(2), RGS20(2), RGS3(5), RGS4(1), RGS6(3), RGS7(3), RYR1(13), RYR2(35), RYR3(28), SLC8A1(7), SLC8A3(1), USP5(5), YWHAB(1), YWHAQ(1)	53423988	371	151	364	114	100	123	44	34	69	1	0.0235	1.000	1.000
462	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(5), CD36(2), COL11A1(20), COL11A2(8), COL1A1(2), COL1A2(5), COL2A1(8), COL3A1(7), COL4A1(2), COL4A2(6), COL4A4(6), COL4A6(4), COL5A1(8), COL5A2(6), COL5A3(1), COL6A1(8), COL6A2(7), COL6A3(13), COL6A6(11), DAG1(1), FN1(7), FNDC1(10), FNDC3A(4), GP5(1), GP6(1), HMMR(4), HSPG2(14), IBSP(5), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAV(5), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), LAMA1(25), LAMA2(9), LAMA3(8), LAMA4(7), LAMA5(14), LAMB1(5), LAMB2(3), LAMB4(8), LAMC1(5), LAMC3(4), RELN(17), SDC2(1), SDC3(1), SDC4(1), SV2A(2), SV2C(3), THBS1(2), THBS2(6), THBS3(2), THBS4(2), TNC(8), TNN(7), TNR(10), TNXB(14), VWF(9)	62721619	420	149	414	118	120	139	44	40	77	0	0.0180	1.000	1.000
463	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(2), ABLIM1(1), ABLIM3(1), ARHGEF12(4), CFL1(1), CXCR4(1), DCC(17), DPYSL2(1), DPYSL5(2), EFNA1(1), EFNA4(1), EFNB2(2), EFNB3(2), EPHA2(6), EPHA3(8), EPHA4(4), EPHA5(8), EPHA6(6), EPHA7(7), EPHA8(6), EPHB1(8), EPHB2(4), EPHB3(1), EPHB4(3), EPHB6(5), FES(1), FYN(1), GNAI1(1), GNAI2(1), GNAI3(1), GSK3B(3), HRAS(1), ITGB1(1), KRAS(3), L1CAM(4), LIMK1(1), LIMK2(3), LRRC4C(8), MAPK1(1), MET(4), NCK1(1), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NGEF(1), NRAS(1), NRP1(4), NTN1(1), NTN4(2), NTNG1(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PLXNA1(6), PLXNA2(12), PLXNA3(2), PLXNB1(8), PLXNB2(13), PLXNB3(5), PLXNC1(2), PPP3CA(1), PPP3CB(2), PPP3CC(3), PTK2(1), RAC1(1), RASA1(9), RGS3(5), RHOA(3), RHOD(1), ROBO1(8), ROBO2(9), ROBO3(4), ROCK1(2), ROCK2(4), SEMA3A(6), SEMA3C(1), SEMA3D(5), SEMA3E(3), SEMA3F(3), SEMA3G(3), SEMA4A(1), SEMA4B(2), SEMA4C(1), SEMA4D(3), SEMA4F(3), SEMA4G(2), SEMA5A(9), SEMA5B(5), SEMA6A(4), SEMA6B(2), SEMA6C(2), SEMA6D(9), SLIT1(6), SLIT2(11), SLIT3(10), SRGAP1(2), SRGAP3(4), UNC5A(2), UNC5B(3), UNC5C(8), UNC5D(10)	54004221	407	147	402	120	84	149	59	47	68	0	0.0646	1.000	1.000
464	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(2), ACTG1(1), ACTN1(1), ACTN2(8), ACTN4(4), AKT1(4), AKT2(1), AKT3(2), AMOTL1(3), ASH1L(5), CASK(3), CGN(3), CLDN15(1), CLDN16(3), CLDN17(3), CLDN18(1), CLDN19(1), CLDN2(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(7), CTNNA2(8), CTNNA3(7), CTNNB1(9), CTTN(1), EPB41(1), EPB41L1(4), EPB41L2(4), EPB41L3(10), EXOC4(4), GNAI1(1), GNAI2(1), GNAI3(1), HCLS1(1), HRAS(1), INADL(6), JAM3(1), KRAS(3), LLGL1(4), LLGL2(3), MAGI1(4), MAGI2(8), MAGI3(3), MLLT4(3), MPDZ(5), MPP5(5), MRAS(1), MYH1(11), MYH10(9), MYH11(5), MYH13(11), MYH14(10), MYH15(7), MYH2(10), MYH3(9), MYH4(7), MYH6(10), MYH7(12), MYH7B(7), MYH8(3), MYH9(2), MYL7(2), MYL9(1), NRAS(1), OCLN(2), PARD3(7), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R3A(4), PPP2R3B(2), PPP2R4(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(4), PRKCZ(2), PTEN(7), RAB3B(1), RHOA(3), SPTAN1(8), SYMPK(4), TJAP1(1), TJP1(6), TJP2(2), TJP3(2), VAPA(1), YES1(5), ZAK(4)	54075502	368	145	365	92	93	129	53	33	59	1	0.00250	1.000	1.000
465	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	252	ACVR1(1), ACVR1B(2), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP7(2), BMPR1A(1), BMPR1B(4), BMPR2(3), CCL14(2), CCL16(2), CCL18(1), CCL20(2), CCL22(1), CCL28(2), CCL5(1), CCL7(1), CCL8(1), CCR1(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CCR9(2), CD40LG(1), CLCF1(1), CNTF(1), CRLF2(1), CSF1(1), CSF1R(9), CSF2RA(2), CSF2RB(6), CSF3(2), CSF3R(5), CX3CL1(1), CX3CR1(3), CXCL1(1), CXCL14(1), CXCL3(1), CXCL6(1), CXCR3(1), CXCR4(1), EDA2R(2), EDAR(1), EGF(4), EGFR(5), EPOR(2), FASLG(1), FLT1(7), FLT3(9), FLT3LG(1), FLT4(5), GDF5(2), GH1(1), GH2(2), GHR(2), HGF(2), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IFNG(1), IFNGR1(1), IL10(2), IL10RA(3), IL10RB(1), IL11RA(1), IL12B(1), IL12RB2(5), IL13RA1(1), IL15(1), IL15RA(1), IL17B(1), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(1), IL19(1), IL1B(3), IL1R1(1), IL1R2(2), IL1RAP(2), IL20(2), IL21(1), IL22RA1(2), IL22RA2(1), IL23R(1), IL26(1), IL2RA(1), IL2RG(3), IL3(2), IL3RA(1), IL4R(3), IL5RA(4), IL6(1), IL6R(1), IL6ST(5), IL7R(3), IL9R(3), INHBA(6), INHBB(1), INHBC(1), INHBE(4), KDR(5), KIT(7), KITLG(2), LEPR(4), LIFR(3), MET(4), MPL(2), NGFR(2), OSMR(3), PDGFB(2), PDGFC(3), PDGFRA(4), PDGFRB(4), PF4(1), PF4V1(2), PLEKHO2(1), PRL(2), PRLR(3), RELT(1), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(1), TNFRSF11B(1), TNFRSF12A(1), TNFRSF18(1), TNFRSF19(2), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(4), TNFRSF4(1), TNFRSF8(5), TNFRSF9(1), TNFSF10(1), TNFSF12(2), TNFSF13B(1), TNFSF14(1), TNFSF4(1), TNFSF9(2), TPO(8), TSLP(1), VEGFC(5), XCL2(1), XCR1(2)	49147061	333	144	327	105	73	101	46	41	72	0	0.240	1.000	1.000
466	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(5), ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADM(1), ARRB1(5), ARRB2(1), ATF4(2), ATP2A2(5), ATP2A3(3), CALM3(1), CAMK2A(3), CAMK2B(2), CNN1(1), CNN2(1), CORIN(2), CRHR1(2), DGKZ(2), FOS(1), GABPA(1), GBA2(1), GJA1(1), GNAQ(1), GNB2(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(2), GRK5(3), GSTO1(1), GUCA2B(2), GUCY1A3(3), IGFBP3(2), IGFBP4(1), IL1B(3), IL6(1), ITPR1(6), ITPR2(8), ITPR3(2), JUN(1), MIB1(1), MYL4(1), MYLK2(1), NFKB1(2), NOS1(6), NOS3(5), OXTR(1), PDE4B(3), PDE4D(6), PKIA(1), PLCB3(4), PLCG1(5), PLCG2(3), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(7), RAMP1(1), RGS11(1), RGS14(1), RGS17(1), RGS18(1), RGS19(1), RGS2(2), RGS20(2), RGS3(5), RGS4(1), RGS6(3), RGS7(3), RLN1(1), RYR1(13), RYR2(35), RYR3(28), SLC8A1(7), SP1(1), TNXB(14), USP5(5), YWHAB(1), YWHAQ(1)	48991189	318	143	315	87	81	112	37	31	56	1	0.00912	1.000	1.000
467	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(5), ACTN2(8), ACTN4(4), DMD(19), MYBPC1(4), MYBPC2(3), MYBPC3(6), MYH3(9), MYH6(10), MYH7(12), MYH8(3), MYL1(1), MYL3(2), MYL4(1), MYL9(1), MYOM1(7), NEB(18), TMOD1(1), TNNI3(1), TNNT2(3), TPM2(1), TPM4(1), TTN(159), VIM(2)	38550052	282	136	282	83	54	103	56	37	29	3	0.303	1.000	1.000
468	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(8), ACACB(9), AKT1(4), AKT2(1), AKT3(2), ARAF(3), BRAF(4), CALM3(1), CBL(6), CBLB(4), CBLC(3), CRK(1), EIF4EBP1(1), ELK1(2), EXOC7(1), FASN(7), FBP2(2), FLOT2(5), FOXO1(2), GCK(1), GSK3B(3), GYS1(2), GYS2(2), HRAS(1), IKBKB(2), INPP5D(4), INSR(9), IRS1(6), IRS2(3), IRS4(3), KRAS(3), LIPE(2), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK9(2), MKNK1(1), MKNK2(2), NRAS(1), PCK1(2), PCK2(2), PDE3A(7), PDE3B(3), PFKL(1), PFKM(4), PFKP(2), PHKA1(5), PHKA2(3), PHKB(4), PHKG1(2), PHKG2(2), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PKLR(3), PPARGC1A(5), PPP1CA(1), PPP1CB(1), PPP1R3A(8), PPP1R3D(1), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKAR1B(2), PRKAR2B(3), PRKCI(1), PRKCZ(2), PTPN1(5), PTPRF(3), PYGB(3), PYGL(3), PYGM(4), RAF1(2), RAPGEF1(4), RHEB(1), SHC4(3), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(3), SOS2(1), SREBF1(3), TRIP10(7), TSC1(10), TSC2(7)	44440949	314	135	305	80	76	103	42	32	61	0	0.00426	1.000	1.000
469	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADSL(3), ADSSL1(1), AK5(3), AK7(2), ALLC(4), AMPD1(3), AMPD2(2), ATIC(2), DCK(1), DGUOK(1), ENPP1(5), ENPP3(4), ENTPD1(2), ENTPD2(1), ENTPD4(1), ENTPD5(3), ENTPD6(1), FHIT(3), GART(2), GDA(2), GMPR2(1), GMPS(3), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), IMPDH1(1), NME6(1), NME7(3), NPR1(6), NPR2(4), NT5C1A(1), NT5C1B(2), NT5M(1), PAPSS2(3), PDE10A(6), PDE11A(5), PDE1A(3), PDE1C(3), PDE2A(3), PDE3B(3), PDE4A(2), PDE4B(3), PDE4C(3), PDE4D(6), PDE5A(4), PDE6H(2), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(5), PDE9A(2), PFAS(4), PKLR(3), PNPT1(1), POLA2(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), POLR1A(4), POLR1B(3), POLR1C(5), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3A(10), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(4), PRIM2(3), PRPS1(1), PRPS2(2), RFC5(1), RRM2B(1), XDH(9)	45240429	274	133	273	83	61	90	47	30	46	0	0.212	1.000	1.000
470	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(2), CADM1(2), CADM3(1), CD2(1), CD22(5), CD226(1), CD28(1), CD34(2), CD40LG(1), CD58(1), CD6(2), CD80(1), CD86(1), CDH1(1), CDH15(1), CDH2(7), CDH3(2), CDH4(6), CDH5(3), CLDN15(1), CLDN16(3), CLDN17(3), CLDN18(1), CLDN19(1), CLDN2(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(2), CNTN1(11), CNTN2(3), CNTNAP1(3), CNTNAP2(7), GLG1(3), HLA-A(1), HLA-B(7), HLA-C(4), HLA-DMB(3), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA2(5), HLA-DRB1(1), HLA-DRB5(2), HLA-E(1), HLA-G(2), ICAM1(1), ICAM2(1), ICAM3(2), ITGA4(5), ITGA6(7), ITGA8(10), ITGA9(2), ITGAL(6), ITGAM(3), ITGAV(5), ITGB1(1), ITGB7(1), JAM3(1), L1CAM(4), MADCAM1(2), MAG(3), MPZL1(3), NCAM1(4), NCAM2(12), NEGR1(5), NEO1(6), NFASC(6), NLGN1(10), NLGN2(1), NLGN3(2), NRCAM(4), NRXN1(8), NRXN2(7), NRXN3(8), OCLN(2), PDCD1(1), PDCD1LG2(2), PTPRC(9), PTPRF(3), PTPRM(9), PVR(2), PVRL1(5), PVRL3(6), SDC2(1), SDC3(1), SDC4(1), SELE(3), SELL(1), SELP(3), SELPLG(1), SIGLEC1(9), SPN(1), VCAM1(4), VCAN(14)	40423305	319	133	317	95	75	109	47	33	53	2	0.0584	1.000	1.000
471	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(2), ACTG1(1), ACTN1(1), ACTN2(8), ACTN4(4), ACVR1B(2), ACVR1C(2), BAIAP2(2), CDH1(1), CREBBP(13), CSNK2A1(1), CSNK2A2(1), CTNNA1(7), CTNNA2(8), CTNNA3(7), CTNNB1(9), CTNND1(9), EGFR(5), EP300(12), ERBB2(12), FARP2(3), FER(2), FGFR1(1), FYN(1), IGF1R(4), INSR(9), IQGAP1(7), LMO7(6), MAP3K7(3), MAPK1(1), MET(4), MLLT4(3), NLK(4), PARD3(7), PTPN1(5), PTPRB(2), PTPRF(3), PTPRJ(6), PTPRM(9), PVRL1(5), PVRL3(6), PVRL4(2), RAC1(1), RHOA(3), SMAD2(2), SMAD3(3), SMAD4(14), SNAI1(1), SNAI2(5), SORBS1(7), SSX2IP(2), TCF7L1(2), TGFBR1(2), TGFBR2(15), TJP1(6), VCL(8), WASF1(3), WASF2(3), WASF3(3), WASL(2), YES1(5)	33176931	287	133	277	61	70	93	28	27	69	0	0.000960	1.000	1.000
472	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(2), ADORA2A(5), ADORA2B(2), ADORA3(1), ADRA1A(7), ADRA1B(1), ADRA1D(3), ADRA2A(3), ADRA2C(2), ADRB1(1), ADRB2(1), AGTR2(2), AVPR1A(3), AVPR2(1), C3AR1(3), CCKAR(1), CCKBR(3), CCR1(1), CCR10(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CCR9(2), CHML(5), CHRM1(2), CHRM2(8), CHRM3(5), CHRM4(2), CHRM5(1), CMKLR1(5), CNR1(3), CNR2(1), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(3), DRD2(4), DRD3(2), DRD4(1), EDNRA(1), EDNRB(3), F2R(4), F2RL1(1), F2RL2(1), F2RL3(2), FPR1(1), FSHR(6), GALR1(2), GALR2(3), GALR3(1), GHSR(2), GNB2L1(2), GPR17(1), GPR173(1), GPR174(2), GPR3(1), GPR37(2), GPR37L1(2), GPR4(1), GPR50(1), GPR63(3), GPR83(5), GPR85(2), GPR87(2), GRPR(1), HCRTR2(6), HRH1(2), HRH2(3), HRH3(1), HTR1A(1), HTR1B(1), HTR1D(4), HTR1E(5), HTR1F(3), HTR2A(4), HTR2C(1), HTR5A(1), HTR7(3), LHCGR(6), MAS1(1), MC1R(2), MC3R(1), MC4R(5), MLNR(1), MTNR1A(1), MTNR1B(2), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), NPY5R(1), NTSR1(1), NTSR2(2), OPN3(2), OPRD1(1), OPRK1(2), OPRL1(4), OPRM1(1), OR10A5(2), OR11A1(1), OR12D3(2), OR1C1(2), OR1Q1(1), OR2H1(1), OR5V1(2), OR7C1(1), OXTR(1), P2RY1(2), P2RY10(3), P2RY11(2), P2RY13(3), P2RY14(1), P2RY6(2), PTGER2(1), PTGER4(3), PTGFR(1), PTGIR(2), RGR(1), RHO(1), RRH(2), SSTR1(2), SSTR3(2), SSTR4(2), SUCNR1(2), TBXA2R(2)	32033299	272	131	270	85	71	92	36	35	38	0	0.0270	1.000	1.000
473	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ADRB1(1), CSNK1D(1), DRD1(3), DRD2(4), EGF(4), EGFR(5), GJA1(1), GJD2(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(16), GRM1(9), GRM5(5), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), HRAS(1), HTR2A(4), HTR2C(1), ITPR1(6), ITPR2(8), ITPR3(2), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K5(2), MAP3K2(3), MAPK1(1), MAPK7(1), NPR1(6), NPR2(4), NRAS(1), PDGFA(2), PDGFB(2), PDGFC(3), PDGFD(1), PDGFRA(4), PDGFRB(4), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PRKACA(3), PRKCA(1), PRKCG(2), PRKG1(3), PRKG2(5), RAF1(2), SOS1(3), SOS2(1), TJP1(6), TUBA1A(2), TUBA1C(1), TUBA3C(7), TUBA3D(4), TUBA3E(1), TUBA8(5), TUBB(1), TUBB1(3), TUBB2A(3), TUBB2B(1), TUBB3(2), TUBB6(2), TUBB8(1)	36723608	248	130	245	70	73	81	39	27	28	0	0.0442	1.000	1.000
474	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(2), ACTN1(1), ACTR3(1), AKT1(4), AKT2(1), AKT3(2), ANGPTL2(3), ARHGEF6(2), ARHGEF7(3), BCAR1(6), BRAF(4), CAV1(1), CDKN2A(19), CRK(1), CSE1L(4), DOCK1(9), EPHB2(4), FYN(1), GRB7(3), ILK(2), ITGA1(3), ITGA10(7), ITGA11(2), ITGA2(6), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), MAP2K4(3), MAP3K11(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2), MRAS(1), MYLK(6), MYLK2(1), P4HB(2), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PIK3CA(21), PIK3CB(4), PKLR(3), PLCG1(5), PLCG2(3), PTEN(7), PTK2(1), RAF1(2), RALA(1), RHO(1), ROCK1(2), ROCK2(4), SOS1(3), SOS2(1), TERF2IP(1), TLN1(7), TLN2(11), ZYX(1)	33818214	244	130	234	54	45	91	26	31	50	1	0.00515	1.000	1.000
475	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	AKT1(4), AKT2(1), AKT3(2), BCL2L1(1), CBL(6), CBLB(4), CBLC(3), CCND1(1), CLCF1(1), CNTF(1), CREBBP(13), CRLF2(1), CSF2RA(2), CSF2RB(6), CSF3(2), CSF3R(5), EP300(12), EPOR(2), GH1(1), GH2(2), GHR(2), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IFNG(1), IFNGR1(1), IL10(2), IL10RA(3), IL10RB(1), IL11RA(1), IL12B(1), IL12RB2(5), IL13RA1(1), IL13RA2(3), IL15(1), IL15RA(1), IL19(1), IL20(2), IL21(1), IL22RA1(2), IL22RA2(1), IL23R(1), IL26(1), IL2RA(1), IL2RG(3), IL3(2), IL3RA(1), IL4R(3), IL5RA(4), IL6(1), IL6R(1), IL6ST(5), IL7R(3), IL9R(3), JAK1(3), JAK2(2), JAK3(6), LEPR(4), LIFR(3), MPL(2), OSMR(3), PIAS1(7), PIAS3(1), PIAS4(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PRL(2), PRLR(3), PTPN11(2), SOCS3(1), SOCS4(2), SOCS5(4), SOS1(3), SOS2(1), SPRED1(2), SPRED2(1), SPRY4(2), STAM(2), STAM2(3), STAT1(3), STAT2(4), STAT3(2), STAT4(5), STAT5A(3), STAT5B(2), STAT6(3), TPO(8), TSLP(1), TYK2(3)	40181493	272	128	259	74	55	88	30	42	57	0	0.100	1.000	1.000
476	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(1), ACTN2(8), ACTN4(4), ARHGAP5(8), BCAR1(6), CDH5(3), CLDN15(1), CLDN16(3), CLDN17(3), CLDN18(1), CLDN19(1), CLDN2(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(2), CTNNA1(7), CTNNA2(8), CTNNA3(7), CTNNB1(9), CTNND1(9), CXCR4(1), CYBA(1), CYBB(2), EZR(1), GNAI1(1), GNAI2(1), GNAI3(1), ICAM1(1), ITGA4(5), ITGAL(6), ITGAM(3), ITGB1(1), ITK(7), JAM3(1), MAPK11(1), MAPK14(1), MLLT4(3), MMP2(3), MMP9(3), MSN(7), MYL7(2), MYL9(1), NCF1(1), NCF4(2), NOX1(1), NOX3(5), OCLN(2), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(1), PTK2B(4), PTPN11(2), PXN(3), RAC1(1), RAP1A(1), RAPGEF3(1), RAPGEF4(7), RASSF5(2), RHOA(3), ROCK1(2), ROCK2(4), SIPA1(3), TXK(1), VAV1(8), VAV2(1), VAV3(2), VCAM1(4), VCL(8)	34440593	262	127	250	68	55	97	39	27	44	0	0.0159	1.000	1.000
477	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(3), BRAF(4), CACNA1A(13), CRHR1(2), GNA12(1), GNA13(3), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAS(16), GNAZ(2), GRIA1(9), GRIA2(8), GRIA3(5), GRID2(7), GRM1(9), GRM5(5), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), HRAS(1), IGF1(1), IGF1R(4), ITPR1(6), ITPR2(8), ITPR3(2), KRAS(3), LYN(2), MAP2K1(2), MAP2K2(3), MAPK1(1), NOS1(6), NOS3(5), NPR1(6), NPR2(4), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PRKCA(1), PRKCG(2), PRKG1(3), PRKG2(5), RAF1(2), RYR1(13)	30965346	222	125	219	54	56	75	34	21	36	0	0.00767	1.000	1.000
478	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(4), AKT3(2), BCAR1(6), CAPN1(1), CAPN11(4), CAPN2(1), CAPN3(3), CAPN5(2), CAPN6(6), CAPN7(1), CAPN9(2), CAPNS1(3), CAV1(1), CRK(1), CSK(2), DOCK1(9), FYN(1), GIT2(2), ILK(2), ITGA10(7), ITGA11(2), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGA7(2), ITGA8(10), ITGA9(2), ITGAD(6), ITGAE(3), ITGAL(6), ITGAM(3), ITGAV(5), ITGAX(2), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(3), ITGB6(4), ITGB7(1), MAP2K1(2), MAP2K2(3), MAPK10(3), MAPK4(2), MAPK6(3), MAPK7(1), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PIK3R2(3), PTK2(1), PXN(3), RAC1(1), RAPGEF1(4), RHO(1), ROCK1(2), ROCK2(4), SDCCAG8(2), SORBS1(7), SOS1(3), TLN1(7), TNS1(7), VAV2(1), VAV3(2), VCL(8), ZYX(1)	37560037	225	123	222	64	56	74	27	23	45	0	0.0862	1.000	1.000
479	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), ATF4(2), CACNA1C(14), CACNA1D(7), CACNA1F(7), CACNA1S(5), CALM3(1), CAMK2A(3), CAMK2B(2), EGFR(5), ELK1(2), GNAQ(1), GNAS(16), GNRH1(1), HRAS(1), ITPR1(6), ITPR2(8), ITPR3(2), JUN(1), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K1(8), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK7(1), MAPK8(1), MAPK9(2), MMP14(4), MMP2(3), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLD1(4), PLD2(3), PRKACA(3), PRKCA(1), PRKCD(2), PTK2B(4), RAF1(2), SOS1(3), SOS2(1)	35964483	218	118	214	63	61	72	23	25	37	0	0.117	1.000	1.000
480	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(2), ALG1(1), ALG10(3), ALG10B(1), ALG11(1), ALG12(3), ALG13(1), ALG14(1), ALG6(2), ALG9(1), B3GNT1(4), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), B4GALT5(1), B4GALT7(3), C1GALT1(1), CHPF(4), CHST1(1), CHST12(1), CHST13(1), CHST14(1), CHST3(2), CHST6(2), CHST7(1), CHSY1(3), DDOST(1), EXT1(4), EXT2(1), EXTL3(3), FUT11(1), FUT8(2), GALNT10(2), GALNT11(1), GALNT12(3), GALNT13(5), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(2), GALNT7(2), GALNT8(5), GALNT9(3), GALNTL5(2), GANAB(2), GCNT1(3), GCNT3(1), GCNT4(4), HS2ST1(1), HS3ST1(4), HS3ST3A1(2), HS3ST5(2), HS6ST1(2), HS6ST2(2), MAN1A1(2), MAN1A2(2), MAN1B1(2), MAN1C1(1), MGAT1(1), MGAT2(1), MGAT3(3), MGAT4A(2), MGAT4B(2), MGAT5(3), MGAT5B(8), NDST1(5), NDST2(5), NDST3(5), NDST4(6), OGT(3), RPN1(3), RPN2(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(2), STT3B(5), WBSCR17(10), XYLT1(3), XYLT2(3)	30302191	204	116	204	66	53	64	33	25	29	0	0.328	1.000	1.000
481	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADSL(3), AK5(3), ALLC(4), AMPD1(3), AMPD2(2), ATIC(2), ATP1B1(1), ATP5A1(2), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5H(1), DCK(1), DGUOK(1), ENPP1(5), ENPP3(4), ENTPD1(2), ENTPD2(1), FHIT(3), GART(2), GDA(2), GMPS(3), GUCY1A2(5), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(3), IMPDH1(1), NPR1(6), NPR2(4), NT5M(1), PAPSS2(3), PDE1A(3), PDE4A(2), PDE4B(3), PDE4C(3), PDE4D(6), PDE5A(4), PDE6B(1), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(2), PFAS(4), PKLR(3), POLB(2), POLD1(3), POLD2(2), POLE(8), POLQ(9), POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLRMT(3), PRPS1(1), PRPS2(2)	35433583	198	116	197	75	42	61	30	27	38	0	0.864	1.000	1.000
482	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM3(1), CDS1(1), CDS2(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKI(11), DGKZ(2), FN3K(2), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(2), INPP5D(4), INPP5E(3), INPPL1(2), ITPK1(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), PI4KA(7), PI4KB(1), PIK3C2A(3), PIK3C2B(5), PIK3C2G(4), PIK3C3(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PIP4K2A(1), PIP4K2B(5), PIP5K1A(1), PIP5K1C(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCD3(2), PLCD4(2), PLCE1(10), PLCG1(5), PLCG2(3), PLCZ1(4), PRKCA(1), PRKCG(2), PTEN(7), PTPMT1(1), SYNJ1(7), SYNJ2(4)	34966886	216	115	208	53	43	84	18	27	42	2	0.0118	1.000	1.000
483	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(1), ACVR1B(2), ACVR1C(2), ACVR2A(1), ACVR2B(1), ACVRL1(3), AMHR2(2), BMP2(1), BMP5(1), BMP6(2), BMP7(2), BMP8B(2), BMPR1A(1), BMPR1B(4), BMPR2(3), CHRD(5), COMP(2), CREBBP(13), CUL1(4), DCN(6), E2F5(1), EP300(12), FST(1), GDF5(2), GDF6(1), GDF7(1), ID1(1), ID3(1), ID4(1), IFNG(1), INHBA(6), INHBB(1), INHBC(1), INHBE(4), LEFTY2(1), LTBP1(10), MAPK1(1), NODAL(1), NOG(1), PITX2(1), PPP2CA(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), RBL1(2), RBL2(4), RHOA(3), ROCK1(2), ROCK2(4), SMAD2(2), SMAD3(3), SMAD4(14), SMAD6(1), SMAD9(2), SMURF1(2), SMURF2(2), SP1(1), TFDP1(1), TGFB2(1), TGFB3(2), TGFBR1(2), TGFBR2(15), THBS1(2), THBS2(6), THBS3(2), THBS4(2), ZFYVE16(3), ZFYVE9(4)	27044229	199	114	194	46	39	69	30	19	42	0	0.0279	1.000	1.000
484	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(2), ABL2(1), AKT1(4), AKT2(1), AKT3(2), ARAF(3), BRAF(4), CAMK2A(3), CAMK2B(2), CBL(6), CBLB(4), CBLC(3), CDKN1A(2), CRK(1), EGF(4), EGFR(5), EIF4EBP1(1), ELK1(2), ERBB2(12), ERBB3(6), ERBB4(17), GAB1(1), GSK3B(3), HRAS(1), JUN(1), KRAS(3), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK9(2), NCK1(1), NCK2(2), NRAS(1), NRG1(8), NRG2(2), NRG3(8), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(1), RAF1(2), SHC4(3), SOS1(3), SOS2(1), STAT5A(3), STAT5B(2), TGFA(1)	28525797	219	113	206	41	48	85	30	23	33	0	9.85e-05	1.000	1.000
485	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), AKAP1(3), AKAP10(2), AKAP11(4), AKAP12(4), AKAP2(7), AKAP3(5), AKAP4(3), AKAP5(1), AKAP6(9), AKAP8(1), AKAP9(14), ARHGEF1(3), CALM3(1), CHMP1B(1), GNA12(1), GNA13(3), GNA14(1), GNA15(2), GNAI2(1), GNAI3(1), GNAL(2), GNAO1(1), GNAQ(1), GNAZ(2), GNB2(1), GNB5(1), GNGT1(1), HRAS(1), IL18BP(1), ITPR1(6), KRAS(3), NRAS(1), PALM2(3), PDE1A(3), PDE1B(3), PDE1C(3), PDE4A(2), PDE4B(3), PDE4C(3), PDE4D(6), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(5), PLCB3(4), PPP3CA(1), PPP3CC(3), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(4), PRKCZ(2), PRKD1(7), PRKD3(1), RHOA(3), SLC9A1(2), USP5(5)	31980176	217	112	213	55	57	64	32	27	37	0	0.0289	1.000	1.000
486	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(5), ADCY2(5), ADCY3(3), ADCY4(4), ADCY5(2), ADCY6(1), ADCY7(5), ADCY8(11), ADCY9(6), CALM3(1), CAMK2A(3), CAMK2B(2), CREB3L1(2), CREB3L2(1), CREB3L4(1), CREBBP(13), CTNNB1(9), DCT(4), DVL2(1), DVL3(2), EDNRB(3), EP300(12), FZD1(4), FZD10(2), FZD2(4), FZD3(1), FZD5(1), FZD6(4), FZD7(3), FZD9(3), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAQ(1), GNAS(16), GSK3B(3), HRAS(1), KIT(7), KITLG(2), KRAS(3), MAP2K1(2), MAP2K2(3), MAPK1(1), MC1R(2), NRAS(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), POMC(2), PRKACA(3), PRKCA(1), PRKCG(2), RAF1(2), TCF7L1(2), TYR(3), TYRP1(1), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT3A(1), WNT5B(2), WNT7B(3), WNT8B(1), WNT9A(2), WNT9B(2)	29873284	209	112	207	61	70	60	33	16	30	0	0.0547	1.000	1.000
487	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2A(2), AMY2B(5), ASCC3(4), ATP13A2(4), DDX18(3), DDX19A(3), DDX23(3), DDX4(3), DDX41(2), DDX47(1), DDX50(2), DDX51(4), DDX52(1), DDX54(1), DDX55(2), DDX56(3), DHX58(1), ENPP1(5), ENPP3(4), ENTPD7(1), EP400(8), ERCC2(2), ERCC3(1), GAA(3), GANC(1), GBA(2), GBE1(3), GCK(1), GUSB(2), GYS1(2), GYS2(2), HK1(1), HK2(3), HK3(2), IFIH1(3), MGAM(9), MOV10L1(4), NUDT8(1), PGM1(1), PYGB(3), PYGL(3), PYGM(4), RAD54B(2), RAD54L(1), RUVBL2(1), SETX(7), SI(14), SKIV2L2(5), SMARCA2(8), SMARCA5(2), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1), UXS1(1)	34453355	180	110	179	55	25	66	27	27	35	0	0.492	1.000	1.000
488	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(7), ABCA10(8), ABCA12(14), ABCA13(19), ABCA2(7), ABCA3(4), ABCA4(4), ABCA5(2), ABCA6(9), ABCA7(5), ABCA8(3), ABCA9(3), ABCB1(7), ABCB10(2), ABCB11(6), ABCB4(4), ABCB5(3), ABCB6(6), ABCB7(1), ABCB8(1), ABCB9(1), ABCC1(3), ABCC10(1), ABCC11(8), ABCC12(5), ABCC2(6), ABCC3(2), ABCC4(6), ABCC5(7), ABCC8(6), ABCC9(12), ABCD2(3), ABCD3(2), ABCD4(1), ABCG1(2), ABCG2(6), ABCG4(1), ABCG5(1), ABCG8(3), CFTR(8), TAP2(1)	33068014	200	109	197	49	35	72	30	16	47	0	0.0125	1.000	1.000
489	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(3), BID(1), BRAF(4), CD244(3), CD48(1), FASLG(1), FCGR3A(1), FYN(1), HLA-A(1), HLA-B(7), HLA-C(4), HLA-E(1), HLA-G(2), HRAS(1), ICAM1(1), ICAM2(1), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IFNG(1), IFNGR1(1), ITGAL(6), KIR2DL3(5), KIR3DL1(3), KIR3DL2(2), KLRC3(1), KLRD1(2), KLRK1(3), KRAS(3), LCK(1), LCP2(4), MAP2K1(2), MAP2K2(3), MAPK1(1), MICA(2), MICB(1), NCR1(2), NCR2(1), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NRAS(1), PAK1(2), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PLCG2(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRF1(4), PRKCA(1), PRKCG(2), PTK2B(4), PTPN11(2), RAC1(1), RAF1(2), SH2D1B(2), SHC4(3), SOS1(3), SOS2(1), SYK(2), TNFRSF10A(1), TNFRSF10B(1), TNFSF10(1), ULBP1(1), VAV1(8), VAV2(1), VAV3(2), ZAP70(3)	31362892	208	109	199	47	43	82	25	20	38	0	0.00350	1.000	1.000
490	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(4), AKT2(1), AKT3(2), BCL10(1), CARD11(5), CBL(6), CBLB(4), CBLC(3), CD28(1), CD3E(1), CD40LG(1), CHUK(5), FOS(1), FYN(1), GRAP2(4), HRAS(1), IFNG(1), IKBKB(2), IL10(2), ITK(7), JUN(1), KRAS(3), LCK(1), LCP2(4), MALT1(1), NCK1(1), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), NFKB2(2), NRAS(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PDCD1(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKCQ(4), PTPRC(9), RASGRP1(4), RHOA(3), SOS1(3), SOS2(1), TEC(1), VAV1(8), VAV2(1), VAV3(2), ZAP70(3)	28021921	203	108	193	42	38	75	32	23	35	0	0.00226	1.000	1.000
491	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(5), ADCY8(11), ARAF(3), ATF4(2), BRAF(4), CACNA1C(14), CALM3(1), CAMK2A(3), CAMK2B(2), CREBBP(13), EP300(12), GNAQ(1), GRIA1(9), GRIA2(8), GRIN2A(3), GRIN2B(5), GRIN2C(3), GRIN2D(2), GRM1(9), GRM5(5), HRAS(1), ITPR1(6), ITPR2(8), ITPR3(2), KRAS(3), MAP2K1(2), MAP2K2(3), MAPK1(1), NRAS(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PPP1R1A(2), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKACA(3), PRKCA(1), PRKCG(2), RAF1(2), RAP1A(1), RAPGEF3(1), RPS6KA1(1), RPS6KA2(1), RPS6KA6(4)	28095699	181	108	180	55	41	60	25	27	28	0	0.248	1.000	1.000
492	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(1), CD14(1), CD1A(5), CD1B(3), CD1C(4), CD1D(2), CD1E(6), CD2(1), CD22(5), CD33(2), CD34(2), CD36(2), CD38(2), CD3E(1), CD5(2), CD55(1), CD59(1), CD7(1), CD9(1), CR1(2), CR2(4), CSF1(1), CSF1R(9), CSF2RA(2), CSF3(2), CSF3R(5), DNTT(1), EPOR(2), FCER2(1), FLT3(9), FLT3LG(1), GP5(1), HLA-DRB1(1), HLA-DRB5(2), IL11RA(1), IL1B(3), IL1R1(1), IL1R2(2), IL2RA(1), IL3(2), IL3RA(1), IL4R(3), IL5RA(4), IL6(1), IL6R(1), IL7R(3), IL9R(3), ITGA1(3), ITGA2(6), ITGA2B(2), ITGA3(3), ITGA4(5), ITGA5(1), ITGA6(7), ITGAM(3), ITGB3(2), KIT(7), KITLG(2), MME(4), TFRC(2), THPO(2), TPO(8)	22750395	169	102	167	46	29	57	22	23	37	1	0.155	1.000	1.000
493	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(2), ACVRL1(3), AKT1(4), AURKB(1), BMPR1A(1), BMPR2(3), BUB1(2), CDKL2(2), CDS1(1), CDS2(1), CLK1(2), CLK4(3), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKZ(2), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(2), ITPKB(6), MAP3K10(4), NEK1(3), NEK3(3), PAK4(2), PIK3C2A(3), PIK3C2B(5), PIK3C2G(4), PIK3CA(21), PIK3CB(4), PIK3CG(1), PIM2(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCG1(5), PLCG2(3), PLK3(1), PRKACA(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(7), PRKG1(3), RAF1(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), STK11(5), TGFBR1(2), VRK1(1)	31911414	189	101	179	45	43	76	20	17	33	0	0.0126	1.000	1.000
494	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), C1QB(2), C1QC(3), C1R(1), C1S(1), C2(2), C3(9), C3AR1(3), C4BPA(1), C4BPB(1), C5(2), C5AR1(1), C6(6), C7(4), C8A(5), C8B(3), C9(2), CD46(5), CD55(1), CD59(1), CFH(10), CFI(1), CPB2(1), CR1(2), CR2(4), F10(2), F11(4), F12(2), F13A1(1), F13B(3), F2(4), F2R(4), F5(4), F7(1), F8(7), F9(1), FGA(4), FGB(3), FGG(1), KLKB1(1), KNG1(2), MASP1(4), MBL2(4), PLAT(1), PLG(3), PROC(1), PROS1(5), SERPINA1(2), SERPINA5(1), SERPINF2(2), SERPING1(2), TFPI(2), THBD(3), VWF(9)	24880504	157	98	155	34	34	53	15	21	34	0	0.0188	1.000	1.000
495	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(5), ASH2L(1), CARM1(2), CTCFL(2), DOT1L(5), EED(2), EHMT1(6), EHMT2(4), EZH1(2), EZH2(1), FBXO11(3), HCFC1(4), HSF4(2), JMJD6(2), KDM6A(8), NSD1(14), OGT(3), PAXIP1(10), PPP1CA(1), PPP1CB(1), PRDM2(2), PRDM6(5), PRDM7(2), PRDM9(10), PRMT1(2), PRMT5(2), PRMT7(2), PRMT8(1), RBBP5(2), SATB1(1), SETD1A(5), SETD1B(3), SETD2(7), SETD8(2), SETDB1(3), SETDB2(5), SETMAR(1), STK38(2), SUV420H1(5), SUV420H2(3), SUZ12(1), WHSC1(5), WHSC1L1(5)	34447065	154	96	150	31	34	49	13	21	36	1	0.0210	1.000	1.000
496	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(4), CEBPA(2), CHUK(5), DAXX(3), ELK1(2), FOS(1), HRAS(1), IKBKB(2), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP2K5(2), MAP3K1(8), MAP3K10(4), MAP3K11(3), MAP3K12(2), MAP3K13(2), MAP3K2(3), MAP3K3(1), MAP3K4(6), MAP3K5(8), MAP3K6(4), MAP3K7(3), MAP3K9(2), MAP4K2(4), MAP4K3(3), MAP4K4(3), MAP4K5(6), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK4(2), MAPK6(3), MAPK7(1), MAPK8(1), MAPK9(2), MAPKAPK2(1), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2C(2), MEF2D(3), MKNK1(1), MKNK2(2), NFKB1(2), PAK1(2), PAK2(1), RAC1(1), RAF1(2), RIPK1(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(4), SP1(1), STAT1(3), TGFB2(1), TGFB3(2), TGFBR1(2), TRAF2(1)	27086930	149	94	148	41	37	45	17	21	29	0	0.221	1.000	1.000
497	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(4), AKT2(1), AKT3(2), BCR(4), BLNK(3), BTK(1), CD22(5), CD81(1), CR2(4), CSK(2), DAG1(1), FLOT2(5), GSK3A(2), GSK3B(3), INPP5D(4), ITPR1(6), ITPR2(8), ITPR3(2), LYN(2), MAPK1(1), NFATC1(4), NFATC2(6), NR0B2(1), PIK3CA(21), PIK3CD(5), PIK3R1(5), PLCG2(3), PPP1R13B(4), PPP3CA(1), PPP3CB(2), PPP3CC(3), PTPRC(9), RAF1(2), SOS1(3), SOS2(1), SYK(2), VAV1(8)	20264444	141	93	132	34	31	53	13	17	26	1	0.0327	1.000	1.000
498	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(2), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(2), INPP5E(3), INPPL1(2), ISYNA1(1), ITPK1(1), ITPKB(6), MIOX(2), PI4KA(7), PI4KB(1), PIK3C3(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIP4K2A(1), PIP4K2B(5), PIP5K1A(1), PIP5K1C(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), PLCD3(2), PLCD4(2), PLCE1(10), PLCG1(5), PLCG2(3), PLCZ1(4), PTEN(7), PTPMT1(1), SYNJ1(7), SYNJ2(4)	20624225	139	91	131	34	24	64	10	15	24	2	0.0286	1.000	1.000
499	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(3), APH1A(1), CREBBP(13), CTBP2(2), DLL1(1), DTX1(3), DTX2(3), DTX3L(2), DTX4(2), DVL2(1), DVL3(2), EP300(12), HDAC1(1), HES1(1), JAG1(2), JAG2(4), LFNG(2), MAML1(2), MAML2(6), MAML3(4), NCOR2(12), NCSTN(1), NOTCH1(20), NOTCH2(6), NOTCH3(13), NOTCH4(7), NUMB(5), NUMBL(3), PSEN1(2), PSEN2(1), RBPJ(1), RBPJL(6), SNW1(1)	19872809	145	90	144	51	36	39	11	14	43	2	0.768	1.000	1.000
500	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(1), ALG6(2), CCKBR(3), CCR2(1), CCR3(2), CCR5(1), CELSR1(8), CELSR2(10), CELSR3(7), CHRM2(8), CHRM3(5), CXCR3(1), DRD4(1), EDNRA(1), EMR2(2), EMR3(3), F2R(4), FSHR(6), GHRHR(2), GPR116(5), GPR132(1), GPR133(3), GPR17(1), GPR18(1), GPR55(1), GPR56(3), GPR84(3), GPR88(1), GRM1(9), GRPR(1), HRH4(2), LGR6(5), LPHN2(9), LPHN3(9), NTSR1(1), OR2M4(4), P2RY11(2), P2RY13(3), PTGFR(1), SMO(4), TAAR5(2), TSHR(3), VN1R1(3)	18000328	145	89	143	40	33	51	24	15	22	0	0.0714	1.000	1.000
501	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(4), CPEB1(1), EGFR(5), ERBB2(12), ERBB4(17), ETS1(1), ETV7(1), FMN2(20), KRAS(3), MAP2K1(2), MAPK1(1), NOTCH1(20), NOTCH2(6), NOTCH3(13), NOTCH4(7), PIWIL1(4), PIWIL2(3), PIWIL3(1), RAF1(2), SOS1(3), SOS2(1), SPIRE1(2), SPIRE2(3)	14758728	132	89	127	35	25	52	15	11	27	2	0.200	1.000	1.000
502	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(4), APOA1(1), CD36(2), CITED2(2), CPT1B(6), CREBBP(13), EHHADH(1), EP300(12), HSD17B4(4), JUN(1), LPL(2), MAPK1(1), ME1(1), MRPL11(1), NCOA1(7), NCOR1(4), NCOR2(12), NR0B2(1), NRIP1(3), PDGFA(2), PIK3CA(21), PIK3R1(5), PPARA(1), PRKAR1B(2), PRKAR2B(3), PRKCA(1), RB1(8), SP1(1), STAT5A(3), STAT5B(2)	17374120	127	89	118	31	20	51	10	8	38	0	0.147	1.000	1.000
503	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(6), CD28(1), CSK(2), DAG1(1), DTYMK(2), EPHB2(4), FBXW7(14), GRAP2(4), ITK(7), ITPKB(6), LCK(1), LCP2(4), MAPK1(1), NCK1(1), NFAT5(4), NFKB1(2), NFKB2(2), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), PLCG1(5), PTPRC(9), RAF1(2), RASGRP1(4), RASGRP2(1), RASGRP3(2), RASGRP4(2), SOS1(3), SOS2(1), VAV1(8), ZAP70(3)	15742505	119	89	116	30	26	39	15	15	24	0	0.111	1.000	1.000
504	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), CABIN1(8), CALM3(1), CAMK2B(2), CD3E(1), CDKN1A(2), CNR1(3), CREBBP(13), CSNK2A1(1), EP300(12), FCGR3A(1), FOS(1), FOSL1(2), GATA3(4), GSK3A(2), GSK3B(3), HRAS(1), IFNB1(1), IFNG(1), IL10(2), IL1B(3), IL2RA(1), IL3(2), IL6(1), ITK(7), KPNA5(1), MAPK14(1), MAPK8(1), MAPK9(2), MEF2A(1), MEF2D(3), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB2(2), NUP214(2), OPRD1(1), P2RX7(2), PAK1(2), PPP3CB(2), PPP3CC(3), PTPRC(9), RPL13A(1), SLA(3), SP1(1), SP3(2), TRAF2(1), TRPV6(3), VAV1(8), VAV2(1), VAV3(2), XPO5(2)	25157462	155	86	154	34	34	55	21	10	35	0	0.0121	1.000	1.000
505	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(4), AKT2(1), AKT3(2), CASP8(6), CCL5(1), CD14(1), CD80(1), CD86(1), CHUK(5), FADD(1), FOS(1), IFNA16(1), IFNA2(1), IFNA7(1), IFNAR1(1), IFNB1(1), IKBKB(2), IKBKE(2), IL12B(1), IL1B(3), IL6(1), IRAK1(2), IRAK4(1), IRF5(1), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K7(3), MAPK1(1), MAPK10(3), MAPK11(1), MAPK14(1), MAPK8(1), MAPK9(2), NFKB1(2), NFKB2(2), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), RAC1(1), RIPK1(2), STAT1(3), TICAM1(1), TLR1(2), TLR2(5), TLR3(1), TLR4(6), TLR6(2), TLR7(1), TLR8(2), TOLLIP(1), TRAF3(1), TRAF6(1)	24297105	140	86	131	33	22	52	24	14	28	0	0.0401	1.000	1.000
506	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(4), AKT2(1), AKT3(2), BCL10(1), BLNK(3), BTK(1), CARD11(5), CD22(5), CD79A(2), CD81(1), CHUK(5), CR2(4), FCGR2B(1), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(2), INPP5D(4), JUN(1), KRAS(3), LILRB3(1), LYN(2), MALT1(1), NFAT5(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), NFKB2(2), NRAS(1), PIK3CA(21), PIK3CB(4), PIK3CD(5), PIK3CG(1), PIK3R1(5), PIK3R2(3), PIK3R3(2), PIK3R5(3), PLCG2(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), RAC1(1), RASGRP3(2), SYK(2), VAV1(8), VAV2(1), VAV3(2)	20540872	149	86	139	34	27	57	21	12	31	1	0.0202	1.000	1.000
507	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(4), CLK3(1), CLK4(3), COL2A1(8), CPSF1(5), CPSF2(3), CPSF3(1), CSTF1(1), CSTF2(2), CSTF2T(2), CSTF3(1), DDX1(4), DDX20(1), DHX15(2), DHX16(1), DHX38(3), DHX8(6), DHX9(7), DICER1(6), FUS(3), GIPC1(5), LSM7(1), METTL3(2), NCBP1(1), NONO(1), PABPN1(1), PAPOLA(2), POLR2A(3), PRPF18(1), PRPF3(2), PRPF4(3), PRPF4B(2), PRPF8(5), PSKH1(1), PTBP1(3), RBM5(2), RNGTT(1), RNMT(2), RNPS1(1), SF3A1(4), SF3A2(1), SF3A3(1), SF3B1(2), SF3B2(4), SF3B4(1), SNRPD2(1), SNRPF(1), SNRPN(4), SNURF(1), SPOP(2), SRPK1(3), SRPK2(2), SUPT5H(3), TXNL4A(1), U2AF2(1), XRN2(1)	29207358	136	83	136	35	30	49	14	13	30	0	0.264	1.000	1.000
508	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), AK3(2), CAD(11), DCK(1), DCTD(1), DHODH(3), DPYD(5), DPYS(4), DTYMK(2), ENTPD1(2), ENTPD4(1), ENTPD5(3), ENTPD6(1), NME6(1), NME7(3), NT5C1A(1), NT5C1B(2), NT5M(1), PNPT1(1), POLA2(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), POLR1A(4), POLR1B(3), POLR1C(5), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3A(10), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(4), PRIM2(3), RFC5(1), RRM2B(1), TXNRD1(3), TXNRD2(2), TYMS(2), UCK1(1), UCK2(1), UMPS(1), UPP1(2), UPP2(1)	22592480	127	80	127	39	32	44	16	11	24	0	0.319	1.000	1.000
509	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(9), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(1), ACSL6(1), ADIPOR1(2), AKT1(4), AKT2(1), AKT3(2), CAMKK2(4), CD36(2), CHUK(5), CPT1A(2), CPT1B(6), CPT1C(2), CPT2(1), IKBKB(2), IRS1(6), IRS2(3), IRS4(3), JAK1(3), JAK2(2), JAK3(6), LEPR(4), MAPK10(3), MAPK8(1), MAPK9(2), NFKB1(2), NFKB2(2), PCK1(2), PCK2(2), POMC(2), PPARA(1), PPARGC1A(5), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKCQ(4), PTPN11(2), SLC2A1(1), SOCS3(1), STAT3(2), STK11(5), TNFRSF1B(1), TRAF2(1), TYK2(3)	22938755	130	79	129	42	34	41	18	9	28	0	0.363	1.000	1.000
510	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(4), CALM3(1), CAV1(1), CHRM1(2), CHRNA1(4), FLT1(7), FLT4(5), KDR(5), NOS3(5), PDE2A(3), PDE3A(7), PDE3B(3), PRKAR1B(2), PRKAR2B(3), PRKG1(3), PRKG2(5), RYR2(35), SLC7A1(2), SYT1(3)	11455365	101	77	99	31	22	36	18	7	18	0	0.240	1.000	1.000
511	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2A(2), AMY2B(5), ENPP1(5), ENPP3(4), GAA(3), GANAB(2), GBE1(3), GCK(1), GUSB(2), GYS1(2), GYS2(2), HK1(1), HK2(3), HK3(2), MGAM(9), PGM1(1), PYGB(3), PYGL(3), PYGM(4), RNPC3(4), SI(14), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1), UXS1(1)	15984577	96	76	95	30	14	39	21	10	12	0	0.479	1.000	1.000
512	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(4), ADCY6(1), ADCY8(11), CACNA1A(13), CACNA1B(6), GNAS(16), GRM4(7), ITPR3(2), KCNB1(1), PDE1A(3), PLCB2(1), PRKACA(3), SCNN1A(3), SCNN1B(1), SCNN1G(5), TAS1R1(2), TAS1R2(4), TAS1R3(2), TAS2R10(1), TAS2R13(2), TAS2R16(1), TAS2R3(1), TAS2R39(1), TAS2R4(1), TAS2R40(1), TAS2R41(1), TAS2R46(3), TAS2R50(2), TAS2R60(3), TAS2R7(1), TAS2R8(1), TRPM5(1)	16025855	105	75	103	38	37	26	13	12	17	0	0.519	1.000	1.000
513	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(3), BID(1), BIRC2(1), BIRC3(2), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CFLAR(2), CHUK(5), CRADD(1), DAXX(3), DFFA(1), DFFB(2), FADD(1), GSN(3), LMNA(2), LMNB1(1), LMNB2(5), MAP3K1(8), MAP3K5(8), MAPK8(1), MDM2(2), NFKB1(2), NUMA1(5), PAK2(1), PRKCD(2), PRKDC(14), PSEN1(2), PSEN2(1), PTK2(1), RASA1(9), RB1(8), RIPK1(2), SPTAN1(8), TNFRSF1B(1), TRAF1(2), TRAF2(1)	19209511	123	74	122	33	24	33	15	15	36	0	0.421	1.000	1.000
514	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(4), APC(15), AR(5), BRAF(4), CCL16(2), DAG1(1), EGFR(5), GNA15(2), GNAI1(1), GNAQ(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), KCNJ5(2), KCNJ9(2), MAPK1(1), MAPK10(3), MAPK14(1), PHKA2(3), PIK3CA(21), PIK3CD(5), PIK3R1(5), PITX2(1), PTX3(1), RAF1(2)	14529520	109	74	100	36	16	39	16	16	22	0	0.580	1.000	1.000
515	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	ACTA1(1), AGT(1), AKT1(4), CALM3(1), CALR(2), CAMK1(1), CAMK1G(2), CREBBP(13), CSNK1A1(2), F2(4), GSK3B(3), HRAS(1), IGF1(1), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK8(1), MEF2C(2), MYH2(10), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NKX2-5(3), PIK3CA(21), PIK3R1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), RAF1(2), SYT1(3)	13744056	114	73	106	31	27	35	14	9	29	0	0.157	1.000	1.000
516	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(15), AXIN1(2), CCND1(1), CSNK1E(1), CTNNB1(9), DVL2(1), DVL3(2), FBXW2(2), FOSL1(2), FRAT1(1), FZD1(4), FZD10(2), FZD2(4), FZD3(1), FZD5(1), FZD6(4), FZD7(3), FZD9(3), GSK3B(3), JUN(1), LDLR(3), MAPK10(3), MAPK9(2), PAFAH1B1(1), PPP2R5C(4), PPP2R5E(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(4), PRKCZ(2), PRKD1(7), RAC1(1), RHOA(3), SFRP4(3), WNT1(1), WNT10B(1), WNT16(2), WNT2B(1), WNT3(1), WNT5B(2), WNT7B(3)	16238863	117	73	115	32	31	30	23	7	25	1	0.195	1.000	1.000
517	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(2), ATP8A1(9), AVPR1A(3), AVPR2(1), C3AR1(3), CCKAR(1), CCKBR(3), CCR1(1), CCR10(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CX3CR1(3), CXCR3(1), CXCR4(1), EDNRA(1), EDNRB(3), FPR1(1), FSHR(6), GALR1(2), GALR2(3), GALR3(1), GHSR(2), GNB2L1(2), GRPR(1), LHCGR(6), MC1R(2), MC2R(1), MC3R(1), MC4R(5), NPY1R(1), NPY2R(1), NPY5R(1), NTSR1(1), NTSR2(2), OPRD1(1), OPRK1(2), OPRL1(4), OPRM1(1), OXTR(1), SSTR1(2), SSTR3(2), SSTR4(2), TAC4(1), TACR3(3), TSHR(3)	13766976	102	72	101	43	25	35	20	5	17	0	0.736	1.000	1.000
518	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(17), B3GALT4(1), CDR1(3), DGKI(11), IL6ST(5), MRPL19(3), PIGK(2), RPL10(1), RPL11(2), RPL13(1), RPL13A(1), RPL18A(1), RPL23(1), RPL26(1), RPL28(1), RPL3(2), RPL30(1), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL36(1), RPL38(1), RPL3L(1), RPL6(1), RPL7A(2), RPL8(2), RPLP0(1), RPLP1(1), RPS10(1), RPS11(2), RPS13(2), RPS14(2), RPS19(3), RPS24(1), RPS26(2), RPS5(2), RPS6KA1(1), RPS6KA2(1), RPS6KA6(4), RPS9(1), SLC36A2(2), TBC1D10C(1), TSPAN9(1)	14646713	94	70	94	29	22	31	7	14	20	0	0.572	1.000	1.000
519	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPL(1), ALPP(5), ASCC3(4), ATP13A2(4), DDX18(3), DDX19A(3), DDX23(3), DDX4(3), DDX41(2), DDX47(1), DDX50(2), DDX51(4), DDX52(1), DDX54(1), DDX55(2), DDX56(3), DHX58(1), ENTPD7(1), EP400(8), ERCC2(2), ERCC3(1), FPGS(1), IFIH1(3), MOV10L1(4), NUDT8(1), QDPR(1), RAD54B(2), RAD54L(1), RUVBL2(1), SETX(7), SKIV2L2(5), SMARCA2(8), SMARCA5(2), SPR(1)	17413325	92	68	92	34	13	31	9	17	22	0	0.827	1.000	1.000
520	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), AOX1(4), CARM1(2), DBH(1), DCT(4), DDC(2), ESCO1(3), ESCO2(1), FAH(2), HEMK1(1), HGD(2), LCMT1(1), MAOA(2), MAOB(3), METTL2B(1), MIF(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), SH3GLB1(2), TAT(2), TH(3), TPO(8), TYR(3), TYRP1(1)	16272572	79	66	79	29	25	26	3	7	18	0	0.592	1.000	1.000
521	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASS(3), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), BBOX1(2), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(6), EHMT2(4), GCDH(1), HADH(1), HADHA(2), HSD17B4(4), HSD3B7(2), NSD1(14), OGDH(2), OGDHL(6), PIPOX(1), PLOD1(3), PLOD2(3), PLOD3(4), RDH13(1), SETD1A(5), SETDB1(3), SHMT1(2), SHMT2(2), TMLHE(1)	15831521	95	65	95	28	24	37	7	7	19	1	0.288	1.000	1.000
522	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT4(3), AGPAT6(1), CDS1(1), CDS2(1), CHAT(8), CHKB(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKI(11), DGKZ(2), ESCO1(3), ESCO2(1), ETNK1(2), ETNK2(2), GNPAT(1), GPAM(1), GPD2(2), LCAT(1), LYPLA1(1), PCYT1A(2), PCYT1B(3), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(1), PLA2G4A(1), PLA2G5(1), PLA2G6(3), PLD1(4), PLD2(3), PPAP2A(2), PPAP2B(3), PTDSS1(2), SH3GLB1(2)	18177635	93	65	92	23	30	30	7	7	19	0	0.0792	1.000	1.000
523	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(5), ACOX1(4), ACOX2(2), ACOX3(1), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(1), ACSL6(1), ANGPTL4(2), APOA1(1), APOA5(2), APOC3(3), AQP7(1), CD36(2), CPT1A(2), CPT1B(6), CPT1C(2), CPT2(1), CYP27A1(2), CYP4A22(2), CYP8B1(1), EHHADH(1), FABP4(1), FABP6(1), FADS2(2), GK(1), GK2(4), HMGCS2(2), ILK(2), LPL(2), ME1(1), MMP1(1), PCK1(2), PCK2(2), PLTP(3), PPARA(1), PPARG(2), SCD(3), SCP2(1), SLC27A2(2), SLC27A4(1), SLC27A5(1), SLC27A6(6), SORBS1(7), UCP1(1)	17867386	97	65	95	27	26	37	6	5	23	0	0.160	1.000	1.000
524	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR3(1), AKT1(4), ANGPTL2(3), DAG1(1), DGKA(3), ETFA(1), ITGA9(2), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), MAP2K1(2), MAPK1(1), PAK1(2), PDE3A(7), PDE3B(3), PIK3C2G(4), PIK3CA(21), PIK3CD(5), PIK3R1(5), PSME1(1), SGCB(1)	13431115	89	64	81	26	12	32	12	15	18	0	0.338	1.000	1.000
525	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AGPAT4(3), AGPAT6(1), AKR1A1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), DAK(1), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKI(11), DGKZ(2), GK(1), GK2(4), GLB1(2), GPAM(1), LCT(8), LIPF(3), LIPG(1), LPL(2), MGLL(1), PNLIPRP1(2), PPAP2A(2), PPAP2B(3)	16301098	91	61	91	37	31	26	10	9	15	0	0.717	1.000	1.000
526	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(4), AKT2(1), AKT3(2), ARHGEF11(1), DLG4(4), GNA13(3), LPA(10), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAPK8(1), NFKB1(2), NFKB2(2), PHKA2(3), PIK3CB(4), PLD1(4), PLD2(3), PLD3(1), PTK2(1), RDX(6), ROCK1(2), ROCK2(4), SERPINA4(4), TBXA2R(2)	13762826	83	61	82	27	22	25	13	6	17	0	0.533	1.000	1.000
527	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(2), CAD(11), DCK(1), DCTD(1), DHODH(3), DPYD(5), DPYS(4), DTYMK(2), ENTPD1(2), NT5M(1), POLB(2), POLD1(3), POLD2(2), POLE(8), POLQ(9), POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLRMT(3), TXNRD1(3), TYMS(2), UCK1(1), UCK2(1), UMPS(1), UPP1(2)	15903058	80	60	79	33	18	28	9	11	14	0	0.869	1.000	1.000
528	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(4), AKT2(1), AKT3(2), BRAF(4), DAG1(1), DRD2(4), EGFR(5), EPHB2(4), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), KCNJ5(2), KCNJ9(2), MAPK1(1), PIK3CB(4), PITX2(1), PLCB1(3), PLCB2(1), PLCB3(4), PLCB4(4), RAF1(2), RGS20(2), SOS1(3), SOS2(1), STAT3(2), TERF2IP(1)	16125997	80	60	80	29	15	33	4	14	14	0	0.624	1.000	1.000
529	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP6(1), CASP7(1), CASP8(6), CFLAR(2), DAXX(3), DFFA(1), DFFB(2), FADD(1), FAF1(3), JUN(1), LMNA(2), LMNB1(1), LMNB2(5), MAP2K4(3), MAP3K1(8), MAP3K7(3), MAPK8(1), PAK1(2), PAK2(1), PRKDC(14), PTPN13(7), RB1(8), RIPK2(1), SPTAN1(8)	11725820	85	59	84	25	11	17	7	18	32	0	0.795	1.000	1.000
530	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTG2(2), ACTR3(1), AKT1(4), ANGPTL2(3), CFL1(1), FLNA(3), FLNC(10), FSCN1(1), FSCN2(2), FSCN3(2), GDI1(1), GDI2(1), LIMK1(1), MYH2(10), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK4(2), PAK6(5), PAK7(5), RHO(1), ROCK1(2), ROCK2(4), WASF1(3), WASL(2)	13261959	79	59	79	25	18	19	16	12	14	0	0.436	1.000	1.000
531	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1A1(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), ALDOB(2), ALDOC(4), BPGM(1), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PGM1(1), PKLR(3)	13443830	76	58	76	25	23	26	6	6	15	0	0.394	1.000	1.000
532	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1A1(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), ALDOB(2), ALDOC(4), BPGM(1), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PGM1(1), PKLR(3)	13443830	76	58	76	25	23	26	6	6	15	0	0.394	1.000	1.000
533	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(8), ACYP1(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1A1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), ALDOB(2), ALDOC(4), BPGM(1), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), LDHAL6A(3), LDHAL6B(1), PDHA2(5), PFKL(1), PFKM(4), PFKP(2), PGK1(1), PGK2(1), PGM1(1), PKLR(3)	16081950	85	58	85	32	24	34	4	9	14	0	0.605	1.000	1.000
534	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(9), AR(5), ESR1(6), ESR2(1), ESRRA(2), HNF4A(3), NPM1(2), NR0B1(1), NR1D1(2), NR1D2(3), NR1I2(2), NR2C2(4), NR2F2(1), NR2F6(1), NR3C1(1), NR4A1(1), NR4A2(3), NR5A2(6), PGR(5), PPARA(1), PPARG(2), RARB(1), RARG(1), ROR1(2), RORA(2), THRA(6), THRB(1), VDR(2)	11421800	76	58	76	25	21	28	8	9	9	1	0.373	1.000	1.000
535	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(4), ATP4B(1), ATP5A1(2), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5H(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), COX5A(1), COX6B2(1), COX6C(1), COX7A1(1), COX8C(1), LHPP(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA4(1), NDUFA7(1), NDUFB10(1), NDUFB7(1), NDUFB8(2), NDUFC2(1), NDUFS1(1), NDUFS2(2), NDUFS3(1), NDUFS8(1), NDUFV2(1), NDUFV3(2), PPA1(1), PPA2(1), SDHA(4), SDHD(2), TCIRG1(1), UQCRC2(4), UQCRFS1(1), UQCRQ(1)	15541817	73	57	73	21	19	25	6	10	13	0	0.259	1.000	1.000
536	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(1), ACTN2(8), BCAR1(6), BCR(4), CAPN1(1), CAPNS1(3), CAPNS2(1), CAV1(1), CSK(2), FYN(1), HRAS(1), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK8(1), PPP1R12B(1), PTK2(1), PXN(3), RAF1(2), RAP1A(1), ROCK1(2), SOS1(3), TLN1(7), VCL(8), ZYX(1)	13230562	71	57	69	25	26	28	5	7	5	0	0.378	1.000	1.000
537	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AGPAT4(3), AKR1A1(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), DGKA(3), DGKB(4), DGKD(2), DGKG(2), DGKH(5), DGKZ(2), GK(1), GLB1(2), LCT(8), LIPF(3), LIPG(1), LPL(2), PNLIPRP1(2), PPAP2A(2), PPAP2B(3)	13430978	79	56	79	28	28	23	10	5	13	0	0.454	1.000	1.000
538	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(6), CARS(5), CARS2(2), DARS2(2), EARS2(1), EPRS(3), FARSA(2), FARSB(1), GARS(3), HARS(1), HARS2(1), IARS(4), IARS2(1), KARS(2), LARS(4), LARS2(2), MARS(3), MARS2(1), MTFMT(1), NARS2(1), QARS(3), RARS(4), RARS2(1), SARS(2), SARS2(1), TARS(6), TARS2(2), VARS(2), VARS2(2), WARS(1), WARS2(2), YARS(1), YARS2(2)	14795164	78	55	78	20	22	27	11	8	10	0	0.167	1.000	1.000
539	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(5), ELK1(2), GNAS(16), GNGT1(1), HRAS(1), IGF1R(4), ITGB1(1), KLK2(1), MAP2K1(2), MAP2K2(3), MAPK1(1), MKNK1(1), MKNK2(2), NGFR(2), PDGFRA(4), PPP2CA(1), PTPRR(6), RAF1(2), RPS6KA1(1), RPS6KA5(4), SOS1(3), STAT3(2)	9301134	65	54	65	24	21	20	9	7	8	0	0.672	1.000	1.000
540	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(4), APC(15), DAG1(1), DLG4(4), EPHB2(4), GNAI1(1), GNAQ(1), ITPR1(6), ITPR2(8), ITPR3(2), KCNJ5(2), KCNJ9(2), MAPK1(1), PITX2(1), PTX3(1), RAC1(1), RHO(1), RYR1(13)	12596477	69	54	68	20	12	22	10	9	16	0	0.358	1.000	1.000
541	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), AOC2(4), AOC3(5), AOX1(4), DBH(1), DCT(4), DDC(2), FAH(2), HGD(2), MAOA(2), MAOB(3), TAT(2), TH(3), TPO(8), TYR(3)	8813162	59	53	59	24	22	16	3	6	12	0	0.662	1.000	1.000
542	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(1), ARG2(1), ASL(3), ASS1(1), CKB(2), CKM(1), CPS1(11), DAO(1), EPRS(3), GAMT(1), GATM(2), GLUD1(1), GLUD2(4), LAP3(1), NOS1(6), NOS3(5), OAT(3), OTC(1), P4HA1(1), P4HA2(3), P4HA3(1), PYCR2(1), PYCRL(1), RARS(4), RARS2(1)	10098952	64	52	64	19	17	23	8	5	11	0	0.313	1.000	1.000
543	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CEBPA(2), CHUK(5), DAXX(3), EGF(4), EGFR(5), ETS1(1), FOS(1), HRAS(1), IKBKB(2), JUN(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAPK1(1), MAPK14(1), MAPK8(1), NFKB1(2), PPP2CA(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(2), PRKCQ(4), RAF1(2), RIPK1(2), SP1(1), TNFRSF1B(1), TRAF2(1)	13434688	72	52	71	23	20	21	13	7	11	0	0.460	1.000	1.000
544	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAX(2), BCL2A1(1), BCL2L1(1), BCL2L2(1), CASP1(5), CASP2(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CD40LG(1), CRADD(1), DAXX(3), DFFA(1), DFFB(2), FADD(1), FASLG(1), IKBKE(2), MCL1(1), NFKB1(2), NGFR(2), NR3C1(1), NTRK1(5), PTPN13(7), RIPK1(2), TFG(2), TNFRSF1B(1), TRAF1(2), TRAF2(1), TRAF3(1), TRAF6(1)	12028345	64	50	64	19	18	17	9	8	12	0	0.347	1.000	1.000
545	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1C2(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), ALDH3B1(2), CYP1A1(3), CYP1A2(1), CYP2B6(1), CYP2C18(3), CYP2C8(1), CYP2C9(4), CYP2E1(2), CYP2F1(4), CYP2S1(1), CYP3A43(1), CYP3A5(2), CYP3A7(1), EPHX1(3), GSTA5(1), GSTK1(2), GSTM3(1), GSTM5(1), GSTP1(1), MGST3(2), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1)	15887502	69	50	69	19	16	26	6	10	11	0	0.249	1.000	1.000
546	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(2), CALM3(1), CAMK2A(3), CAMK2B(2), F2(4), FYN(1), GNAI1(1), GNGT1(1), HRAS(1), JAK2(2), MAP2K1(2), MAP2K2(3), MAPK1(1), MAPK14(1), MAPK8(1), MAPT(1), MYLK(6), PLCG1(5), PRKCA(1), PTK2B(4), RAF1(2), SOS1(3), STAT1(3), STAT3(2), STAT5A(3), SYT1(3)	11643217	60	49	60	20	17	21	9	3	10	0	0.476	1.000	1.000
547	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM3(1), CAMK1(1), CAMK1G(2), ELK1(2), FPR1(1), GNA15(2), GNGT1(1), HRAS(1), MAP2K1(2), MAP2K2(3), MAP3K1(8), MAPK1(1), MAPK14(1), NCF1(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(4), NFKB1(2), PAK1(2), PIK3C2G(4), PLCB1(3), PPP3CA(1), PPP3CB(2), PPP3CC(3), RAC1(1), RAF1(2), SYT1(3)	10677336	66	49	66	21	18	19	7	8	14	0	0.420	1.000	1.000
548	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), CALM3(1), EGFR(5), ELK1(2), GNAQ(1), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(3), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK8(1), MEF2A(1), MEF2C(2), MEF2D(3), PAK1(2), PRKCA(1), PTK2(1), PTK2B(4), RAC1(1), RAF1(2), SOS1(3), SYT1(3)	9489899	53	47	53	19	13	18	5	6	11	0	0.649	1.000	1.000
549	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(1), B4GALT6(3), CERK(4), DEGS1(1), DEGS2(1), ENPP7(1), GAL3ST1(2), GBA(2), GLB1(2), LCT(8), NEU1(1), NEU2(2), NEU4(4), PPAP2A(2), PPAP2B(3), SGMS1(1), SMPD1(2), SMPD3(1), SMPD4(1), SPHK2(3), SPTLC1(1), SPTLC2(4), UGCG(1), UGT8(1)	9843835	54	47	54	20	11	20	6	4	13	0	0.579	1.000	1.000
550	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH3B1(2), ALDH9A1(1), AMDHD1(3), AOC2(4), AOC3(5), ASPA(2), CARM1(2), DDC(2), FTCD(2), HAL(1), HARS(1), HARS2(1), HDC(2), HEMK1(1), HNMT(1), LCMT1(1), MAOA(2), MAOB(3), METTL2B(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), PRPS1(1), PRPS2(2), UROC1(3)	10969610	60	46	60	20	18	19	3	10	10	0	0.469	1.000	1.000
551	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(1), ARHGAP5(8), ARHGAP6(2), ARHGEF1(3), ARHGEF11(1), ARHGEF5(1), BAIAP2(2), CFL1(1), DIAPH1(2), GSN(3), LIMK1(1), MYLK(6), OPHN1(1), PIP5K1A(1), PPP1R12B(1), ROCK1(2), TLN1(7), VCL(8)	12589405	51	46	49	21	10	19	11	4	7	0	0.781	1.000	1.000
552	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	DAXX(3), ELK1(2), HRAS(1), HSPB2(1), MAP2K4(3), MAP3K1(8), MAP3K5(8), MAP3K7(3), MAP3K9(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2C(2), MEF2D(3), MKNK1(1), PLA2G4A(1), RAC1(1), RIPK1(2), RPS6KA5(4), STAT1(3), TGFB2(1), TGFB3(2), TGFBR1(2), TRAF2(1)	10317674	60	44	59	18	17	16	6	9	12	0	0.457	1.000	1.000
553	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA2(2), POLB(2), POLD1(3), POLD2(2), POLD3(3), POLE(8), POLE2(1), POLH(2), POLI(1), POLM(1), POLQ(9), PRIM1(4), PRIM2(3), REV1(4), REV3L(11), RFC5(1)	11320976	57	43	57	23	8	23	8	10	8	0	0.900	1.000	1.000
554	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(3), AKT1(4), AKT2(1), AKT3(2), DAG1(1), GNAQ(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), NFKB1(2), NFKB2(2), PHKA2(3), PIK3CB(4), PITX2(1), PLD1(4), PLD2(3), PLD3(1), VN1R1(3)	12621471	57	43	56	25	11	20	4	7	15	0	0.895	1.000	1.000
555	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(4), BLNK(3), ELK1(2), FOS(1), HRAS(1), JUN(1), LYN(2), MAP2K1(2), MAP3K1(8), MAPK1(1), MAPK8IP3(4), PAPPA(6), RAC1(1), RPS6KA1(1), SOS1(3), SYK(2), VAV1(8), VAV2(1), VAV3(2)	8939971	53	42	53	17	10	13	8	9	13	0	0.632	1.000	1.000
556	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), BTG1(1), CBX3(1), CRY1(1), CRY2(2), DAZAP2(3), DNAJA1(4), EIF4G2(1), GFRA1(3), GSTM3(1), GSTP1(1), HERPUD1(1), IDI1(1), MYF6(1), NCKAP1(4), NCOA4(2), NR1D2(3), PER1(5), PER2(5), PURA(1), SF3A3(1), SUMO3(1), TOB1(2), TUBB3(2), UCP3(2), VAPA(1), ZFR(2)	10038928	54	41	54	19	9	19	7	4	15	0	0.759	1.000	1.000
557	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BID(1), BIRC2(1), BIRC3(2), CASP6(1), CASP7(1), CASP8(6), CASP9(1), CFLAR(2), CHUK(5), DFFA(1), DFFB(2), FADD(1), GAS2(2), LMNA(2), NFKB1(2), RIPK1(2), SPTAN1(8), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(4), TNFSF10(1), TNFSF12(2), TRAF2(1)	9209228	53	41	53	18	11	16	6	9	11	0	0.719	1.000	1.000
558	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), ALDOC(4), DLAT(1), DLD(4), ENO1(1), ENO2(3), FBP2(2), GAPDH(2), GCK(1), HK1(1), HK2(3), HK3(2), LDHAL6B(1), MDH1(2), MDH2(2), PC(1), PCK1(2), PDHA2(5), PDHX(1), PFKL(1), PFKM(4), PFKP(2), PGK1(1), PGK2(1), PKLR(3), TNFAIP1(1)	11691304	53	41	53	18	13	21	6	3	10	0	0.448	1.000	1.000
559	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM3(1), CHUK(5), GNAQ(1), MAP3K1(8), NFATC1(4), NFATC2(6), NFKB1(2), PLCG1(5), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), SYT1(3), VIP(2)	7453006	48	40	48	19	11	13	6	3	15	0	0.848	1.000	1.000
560	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(2), ARSD(1), CARM1(2), CYP11B1(2), CYP11B2(4), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD11B2(1), HSD17B1(1), HSD3B1(2), HSD3B2(3), LCMT1(1), METTL2B(1), PRMT3(2), PRMT5(2), PRMT7(2), PRMT8(1), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A3(1), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(1), UGT2B4(1)	13674297	48	39	48	21	9	23	4	4	8	0	0.873	1.000	1.000
561	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(15), CERK(4), CREB5(2), DAG1(1), EPHB2(4), FOS(1), GNAQ(1), ITPKB(6), JUN(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(4), MAPK9(2)	7555571	50	39	49	18	9	15	7	3	16	0	0.820	1.000	1.000
562	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOB(2), ALDOC(4), FBP2(2), FPGT(5), FUK(5), GMDS(1), GMPPA(1), HK1(1), HK2(3), HK3(2), HSD3B7(2), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(5), PFKFB1(2), PFKFB2(1), PFKFB3(2), PFKFB4(1), PFKL(1), PFKM(4), PFKP(2), PMM1(1), PMM2(1), RDH13(1), TSTA3(2)	10507009	54	38	53	20	12	24	3	5	10	0	0.512	1.000	1.000
563	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(1), CAPN2(1), CAPNS1(3), CAPNS2(1), CXCR3(1), EGF(4), EGFR(5), HRAS(1), ITGA1(3), ITGB1(1), MAPK1(1), MYLK(6), PRKAR1B(2), PRKAR2B(3), PTK2(1), PXN(3), TLN1(7)	9090625	45	38	45	24	12	20	6	2	5	0	0.921	1.000	1.000
564	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2E1(1), GTF2F1(5), HDAC3(3), NCOA1(7), NCOA2(6), NCOA3(3), NCOR2(12), POLR2A(3), TBP(2)	6960463	43	38	43	16	7	19	3	4	10	0	0.696	1.000	1.000
565	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(2), CFL1(1), GNAQ(1), GNAS(16), GNGT1(1), HRAS(1), LIMK1(1), MAP2K1(2), MAPK1(1), NOX1(1), PIK3C2G(4), PLCB1(3), PPP1R12B(1), PRKCA(1), PTK2(1), RAF1(2), ROCK2(4)	7040132	43	37	43	13	15	15	5	3	5	0	0.425	1.000	1.000
566	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT1(3), B4GALT2(1), FBP2(2), GAA(3), GALE(1), GANAB(2), GCK(1), GLB1(2), HK1(1), HK2(3), HK3(2), LCT(8), MGAM(9), PFKM(4), PFKP(2), PGM1(1)	9016164	45	37	45	16	11	17	6	2	9	0	0.593	1.000	1.000
567	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(9), C5(2), C6(6), C7(4), ICAM1(1), IL6(1), ITGA4(5), ITGAL(6), ITGB1(1), SELP(3), SELPLG(1), VCAM1(4)	6813809	43	37	43	16	4	20	3	7	9	0	0.710	1.000	1.000
568	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(2), DAG1(1), ITPKB(6), ITPR1(6), ITPR2(8), ITPR3(2), NFAT5(4), PDE6A(2), PDE6B(1), PDE6C(3), PDE6H(2), SLC6A13(5), TF(4)	9860333	49	37	49	19	8	24	4	6	7	0	0.644	1.000	1.000
569	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN2(8), CAPN1(1), CAPNS1(3), CAPNS2(1), ITGA1(3), ITGB1(1), ITGB3(2), PTK2(1), PXN(3), RAC1(1), SPTAN1(8), TLN1(7)	7899281	41	37	41	17	14	17	0	5	5	0	0.657	1.000	1.000
570	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP4B(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(1), ATP6V1D(2), ATP6V1E1(1), ATP6V1H(3), ATP7B(4), COX5A(1), COX6C(1), COX7A1(1), NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB7(1), NDUFS1(1), NDUFS2(2), NDUFV2(1), PPA2(1), SDHA(4), SHMT1(2), UQCRFS1(1)	10502103	42	36	42	12	12	12	5	6	7	0	0.314	1.000	1.000
571	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(2), ARSD(1), GAL3ST1(2), GBA(2), GLB1(2), LCT(8), NEU1(1), NEU2(2), NEU4(4), PPAP2A(2), PPAP2B(3), SMPD1(2), SPTLC1(1), SPTLC2(4), UGCG(1)	6588452	39	35	39	16	9	14	6	2	8	0	0.715	1.000	1.000
572	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT1(3), B4GALT2(1), GAA(3), GALE(1), GANC(1), GCK(1), GLB1(2), HK1(1), HK2(3), HK3(2), HSD3B7(2), LCT(8), MGAM(9), PFKL(1), PFKM(4), PFKP(2), PGM1(1), RDH13(1)	10750438	46	35	46	17	13	15	6	3	9	0	0.623	1.000	1.000
573	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(5), IFNB1(1), IKBKB(2), IL1B(3), IL1R1(1), IL1RAP(2), IL1RN(1), IL6(1), IRAK1(2), IRAK3(1), JUN(1), MAP3K1(8), MAP3K7(3), MAPK14(1), MAPK8(1), NFKB1(2), TGFB2(1), TGFB3(2), TOLLIP(1), TRAF6(1)	8225044	40	35	39	16	8	11	4	6	11	0	0.860	1.000	1.000
574	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(5), CCNB1(1), GNAI1(1), GNAS(16), GNGT1(1), HRAS(1), MAPK1(1), MYT1(4), PRKAR1B(2), PRKAR2B(3), RPS6KA1(1)	5623036	37	33	37	18	13	10	4	3	7	0	0.900	1.000	1.000
575	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(2), PGAP1(1), PIGB(1), PIGG(1), PIGK(2), PIGN(6), PIGO(3), PIGQ(5), PIGS(4), PIGT(4), PIGW(1), PIGZ(1)	6769771	33	32	33	13	4	14	4	6	5	0	0.732	1.000	1.000
576	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(4), ACAD8(1), ACAD9(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), AKR1C4(2), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CEL(4), CYP27A1(2), HSD3B7(2), RDH13(1), SLC27A5(1), SOAT1(1), SOAT2(1)	8820515	40	31	40	20	12	12	5	4	7	0	0.912	1.000	1.000
577	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(4), F2R(4), F2RL3(2), GNAI1(1), GNGT1(1), HRAS(1), ITGA1(3), ITGB1(1), MAP2K1(2), MAPK1(1), PLA2G4A(1), PLCB1(3), PRKCA(1), PTGS1(2), PTK2(1), RAF1(2), SYK(2), TBXAS1(2)	6688883	34	31	34	14	11	13	3	2	5	0	0.709	1.000	1.000
578	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(2), CASP8(6), FADD(1), MAP2K1(2), MAP2K4(3), MAP3K1(8), MAPK1(1), MAPK8(1), NFKB1(2), NSMAF(4), RAF1(2), RIPK1(2), SMPD1(2), TRAF2(1)	5541878	37	30	37	13	10	12	5	4	6	0	0.619	1.000	1.000
579	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM3(1), DLG4(4), GRIN2A(3), GRIN2B(5), GRIN2C(3), GRIN2D(2), NOS1(6), PPP3CA(1), PPP3CB(2), PPP3CC(3), PRKAR1B(2), PRKAR2B(3), PRKCA(1), SYT1(3)	6975540	39	30	39	21	9	15	5	3	7	0	0.937	1.000	1.000
580	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(1), GTF2A2(1), GTF2E1(1), GTF2H1(1), ILK(2), MNAT1(1), POLR1A(4), POLR1B(3), POLR2A(3), POLR2B(3), POLR2C(1), POLR2H(1), POLR3B(5), POLR3D(2), POLR3H(1), POLR3K(1), TAF5(2), TAF6(1), TAF7(1), TBP(2)	9508564	37	30	37	17	9	8	6	4	10	0	0.934	1.000	1.000
581	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(3), CHAT(8), DBH(1), DDC(2), GAD1(3), GAD2(2), HDC(2), MAOA(2), PAH(4), SLC18A3(1), TH(3), TPH1(2)	4008353	33	29	33	14	13	11	2	3	4	0	0.662	1.000	1.000
582	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(3), ACE2(3), AGT(1), AGTR2(2), ANPEP(1), CMA1(1), CPA3(2), ENPEP(4), LNPEP(3), MAS1(1), MME(4), NLN(3), REN(2), THOP1(1)	5721276	31	29	31	13	4	15	2	3	7	0	0.781	1.000	1.000
583	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(4), CREB5(2), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(4), MAP2K1(2), MAP2K2(3), MAPK1(1), MKNK1(1), MKNK2(2), NFKB1(2), RAP1A(1), RPS6KA1(1), RPS6KA2(1), SOS1(3), SOS2(1), TRAF3(1)	8166774	33	29	32	17	10	9	3	6	5	0	0.935	1.000	1.000
584	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(3), B3GAT2(2), B4GALT7(3), CHPF(4), CHST12(1), CHST13(1), CHST14(1), CHST3(2), CHST7(1), CHSY1(3), DSE(3), XYLT1(3), XYLT2(3)	3879819	30	28	30	15	15	7	0	5	3	0	0.878	1.000	1.000
585	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(8), ARHGEF1(3), GNA12(1), GNA13(3), GNAQ(1), GNGT1(1), MYLK(6), PLCB1(3), PPP1R12B(1), PRKCA(1), ROCK1(2)	5736940	30	28	30	14	3	11	10	3	3	0	0.898	1.000	1.000
586	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(2), GALNT2(2), GALNT3(2), GALNT7(2), GALNT8(5), GALNT9(3), GCNT1(3), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1), WBSCR17(10)	4052521	34	28	34	12	8	8	10	6	2	0	0.696	1.000	1.000
587	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), ARSB(2), ARSD(1), CYP11B1(2), CYP11B2(4), HSD11B1(1), HSD11B2(1), HSD3B1(2), HSD3B2(3), UGT1A1(1), UGT1A10(1), UGT1A4(2), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(2), UGT2B4(1)	7425573	31	27	31	12	8	12	4	4	3	0	0.685	1.000	1.000
588	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1), CYP2C9(4), DHRS1(1), DHRS3(2), DHRSX(1), ECHS1(1), EHHADH(1), ESCO1(3), ESCO2(1), HADHA(2), SH3GLB1(2), YOD1(1)	8237049	31	27	31	10	8	12	2	2	7	0	0.645	1.000	1.000
589	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(7), APOA1(1), APOA4(1), APOC2(1), APOC3(3), APOE(1), HMGCR(1), LCAT(1), LDLR(3), LPL(2), LRP1(8), SCARB1(3), SOAT1(1)	7492972	33	27	33	10	10	13	2	2	6	0	0.288	1.000	1.000
590	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), CSNK1D(1), DRD1(3), DRD2(4), GRM1(9), PLCB1(3), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKAR1B(2), PRKAR2B(3)	4290671	29	26	29	11	7	12	2	3	5	0	0.597	1.000	1.000
591	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(2), HGSNAT(3), HPSE2(3), HYAL2(2), IDUA(1), LCT(8), NAGLU(3), SPAM1(1)	5761800	30	26	30	11	6	11	4	4	5	0	0.642	1.000	1.000
592	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), CD38(2), ENPP1(5), ENPP3(4), NADSYN1(2), NMNAT1(2), NMNAT2(2), NNMT(2), NNT(2), NT5M(1)	3981039	26	26	26	10	0	15	0	5	6	0	0.802	1.000	1.000
593	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(4), EPHB1(8), FYN(1), ITGA1(3), ITGB1(1), L1CAM(4), LYN(2), SELP(3)	4270739	27	24	27	15	5	13	4	2	3	0	0.918	1.000	1.000
594	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPOR(2), FOS(1), HRAS(1), JAK2(2), JUN(1), MAP2K1(2), MAPK8(1), PLCG1(5), RAF1(2), SOS1(3), STAT5A(3), STAT5B(2)	6091421	28	24	28	10	9	10	2	3	4	0	0.619	1.000	1.000
595	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(8), ACACB(9), FASN(7), OXSM(1)	4516159	25	23	25	14	6	8	3	3	5	0	0.914	1.000	1.000
596	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(8), CPT1A(2), LEPR(4), PRKAA1(2), PRKAA2(1), PRKAB1(2), PRKAB2(2), PRKAG1(1), PRKAG2(1)	3968022	23	23	23	10	3	12	4	2	2	0	0.845	1.000	1.000
597	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), BHMT(3), DNMT1(2), DNMT3A(4), DNMT3B(1), MARS(3), MARS2(1), MAT1A(1), MAT2B(2), MTR(7)	4851690	26	23	26	10	7	10	1	5	3	0	0.665	1.000	1.000
598	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), FUCA2(3), GLB1(2), LCT(8), MAN2C1(4), MANBA(1), NEU1(1), NEU2(2), NEU4(4)	4509704	26	23	26	10	3	15	5	0	3	0	0.685	1.000	1.000
599	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(2), IARS(4), IARS2(1), ILVBL(1), LARS(4), LARS2(2), PDHA2(5), VARS(2), VARS2(2)	5058240	23	22	23	10	6	7	4	3	3	0	0.802	1.000	1.000
600	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(3), GLB1(2), LCT(8), SLC33A1(2), ST3GAL1(2), ST3GAL2(2), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(2), ST6GALNAC6(1)	4385856	25	22	25	10	7	7	6	3	2	0	0.729	1.000	1.000
601	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(1), ITGA4(5), ITGAL(6), ITGAM(3), ITGB1(1), SELE(3), SELL(1), SELP(3)	4488002	23	22	22	13	3	11	2	2	5	0	0.933	1.000	1.000
602	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR2(1), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CD28(1), CXCR3(1), CXCR4(1), IFNG(1), IFNGR1(1), IL12B(1), IL12RB2(5), IL18R1(1), IL4R(3), TGFB2(1), TGFB3(2)	5483732	27	22	26	12	6	8	3	7	3	0	0.821	1.000	1.000
603	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB3(1), PSMB5(1), PSMB6(2), PSMB7(1), PSMC3(1), PSMD1(5), PSMD11(1), PSMD12(2), PSMD2(2), PSMD6(1)	4416957	23	21	23	10	4	10	4	2	3	0	0.840	1.000	1.000
604	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(6), FOS(1), HRAS(1), IL3(2), IL3RA(1), JAK2(2), MAP2K1(2), RAF1(2), SOS1(3), STAT5A(3), STAT5B(2)	4957079	25	21	25	10	8	7	2	4	4	0	0.674	1.000	1.000
605	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(3), POLD2(2), POLE(8), POLQ(9)	4567107	24	20	24	14	3	7	2	6	6	0	0.980	1.000	1.000
606	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), DHRS1(1), DHRS3(2), DHRSX(1), ESCO1(3), ESCO2(1), SH3GLB1(2)	6622347	21	19	21	10	6	7	2	1	5	0	0.890	1.000	1.000
607	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(8), PCYT1A(2), PDHA2(5), SLC18A3(1)	1894261	19	18	19	13	7	7	3	0	2	0	0.956	1.000	1.000
608	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH6(1), ADH7(4), ADHFE1(3), ALDH1A3(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3A2(3), ALDH9A1(1)	3623754	20	17	20	11	9	6	0	2	3	0	0.901	1.000	1.000
609	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(3), CNR2(1), DNMT1(2), MTNR1A(1), MTNR1B(2), PTGER2(1), PTGER4(3), PTGFR(1), PTGIR(2), TBXA2R(2)	3017117	18	17	18	10	4	5	2	4	3	0	0.835	1.000	1.000
610	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(1), ITGA4(5), ITGAL(6), ITGB1(1), SELE(3), SELL(1)	3397097	17	16	16	11	2	8	2	2	3	0	0.958	1.000	1.000
611	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPL(1), ALPP(5), FPGS(1), SPR(1)	1878234	8	8	8	10	2	3	0	1	2	0	0.993	1.000	1.000
612	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST12(1), CHST13(1), PAPSS2(3), SULT1A1(1), SULT2B1(1), SUOX(1)	2550304	8	8	8	11	3	3	2	0	0	0	0.999	1.000	1.000
613	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS2(3), SUOX(1)	1626586	4	4	4	5	0	2	2	0	0	0	0.990	1.000	1.000
614	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(2)	456615	2	2	2	2	2	0	0	0	0	0	0.921	1.000	1.000
615	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PRKCA(1)	1385008	2	2	2	3	1	1	0	0	0	0	0.958	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		139243	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
