rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC2(1), ANAPC4(5), ANAPC5(1), ANAPC7(2), BTRC(2), CDC16(3), CDC20(1), CDC23(2), CDC27(1), CUL1(3), CUL2(1), CUL3(6), FBXW11(1), FBXW7(2), FZR1(3), ITCH(1), SKP2(1), SMURF1(1), SMURF2(2), TCEB1(3), TCEB2(1), UBA1(1), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), VHL(237), WWP2(3)	26842932	294	255	193	13	10	17	29	83	153	2	9.24e-12	<1.00e-15	<4.10e-13
2	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF1(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(2), EIF2S2(2), FLT1(7), FLT4(7), HIF1A(3), HRAS(1), KDR(5), NOS3(2), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(1), PXN(1), SHC1(3), VHL(237)	22290046	294	252	193	16	12	21	29	80	151	1	5.37e-11	1.33e-15	4.10e-13
3	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), COPS5(1), EP300(11), HIF1A(3), JUN(2), NOS3(2), VHL(237)	11058426	258	235	158	10	8	11	27	68	143	1	2.16e-11	4.66e-15	9.57e-13
4	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(3), AKT3(1), GRB2(2), ILK(4), MAPK3(1), PDK1(1), PIK3CA(10), PIK3CD(1), PTEN(21), PTK2B(3), RBL2(2), SHC1(3), SOS1(5)	13295530	58	51	53	3	4	13	4	14	22	1	0.000370	1.92e-07	2.96e-05
5	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MAX(5), SP1(2), SP3(2), TP53(15), WT1(3)	4549903	29	25	27	3	1	3	1	10	12	2	0.138	0.000104	0.0109
6	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(10), HLA-DRA(1), HLA-DRB1(1)	1356343	13	13	7	1	1	1	0	1	9	1	0.705	0.000111	0.0109
7	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), ARF3(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CFL1(1), E2F1(1), PRB1(6), TP53(15)	5336707	37	29	27	3	1	2	4	6	22	2	0.106	0.000126	0.0109
8	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(3), AKT3(1), CDKN1A(1), ELK1(1), GRB2(2), HRAS(1), NGFR(1), NTRK1(5), PIK3CA(10), PIK3CD(1), SHC1(3), SOS1(5)	10262631	35	34	31	1	2	10	3	16	4	0	0.000681	0.000142	0.0109
9	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ARPC2(8), CDC42(1), PAK1(2), PDGFRA(5), PIK3CA(10), PIK3R1(2), WASL(6)	8954221	35	35	26	2	0	7	2	13	13	0	0.0123	0.000252	0.0172
10	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(4), AKT1(1), ATM(15), CDKN1A(1), CPB2(5), CSNK1A1(2), FHL2(1), HIF1A(3), IGFBP3(1), NFKBIB(1), TP53(15)	13158403	49	43	44	3	1	6	5	14	21	2	0.00597	0.000386	0.0238
11	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1), CD3E(1), CD3G(2), CD4(10)	2162366	14	14	8	1	1	1	1	2	8	1	0.536	0.000995	0.0557
12	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(2), EIF2S2(2), NFKB1(1), RELA(5), TP53(15)	6588881	26	22	21	1	1	6	1	5	10	3	0.0262	0.00251	0.129
13	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(2), CD3E(1), CD3G(2), CD4(10), CD8A(1), IL3(1), KITLG(2)	4130035	21	19	15	2	1	2	1	5	11	1	0.461	0.00329	0.156
14	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT1(3), GOT2(2), TAT(1), TYR(5)	3135385	13	13	13	1	1	0	3	4	5	0	0.272	0.00414	0.182
15	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(3), GRB2(2), ILK(4), ITGB1(4), MAPK3(1), PDK2(2), PIK3CA(10), PIK3R1(2), PTEN(21), PTK2(1), SHC1(3), SOS1(5)	12533863	59	50	54	7	3	11	3	17	24	1	0.0524	0.00481	0.197
16	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(2), GNAS(5), GNB1(2), PPP2CA(1), PRKAA2(4), PRKAB1(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAG2(4), PRKAR1A(2), PRKAR2B(2)	9860005	31	29	28	1	3	3	2	12	11	0	0.00869	0.00945	0.351
17	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(2), CTH(1), DNMT1(21), DNMT3A(12), DNMT3B(2), MARS(2), MARS2(3)	11258234	44	39	25	2	2	2	5	9	26	0	0.0585	0.00969	0.351
18	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(6), EGF(4), EGFR(9), HGS(2), RAB5A(1), TFRC(2)	8444563	24	23	22	0	4	1	5	6	8	0	0.00556	0.0108	0.368
19	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD3G(2), CD4(10), FYN(2), HLA-DRA(1), HLA-DRB1(1), PTPRC(6)	5701434	23	22	17	1	0	2	1	8	11	1	0.249	0.0125	0.406
20	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2B5(2), EIF2S2(2), EIF4E(1), GSK3B(3), IGF1R(1), INPPL1(2), PDK2(2), PIK3CA(10), PIK3R1(2), PPP2CA(1), PTEN(21), RPS6KB1(2)	12904411	50	44	45	5	2	9	1	14	23	1	0.0179	0.0146	0.449
21	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(1), GOT1(3), GOT2(2), LDHB(1), LDHC(3), MPST(2)	4479216	18	18	16	2	1	0	2	5	10	0	0.390	0.0168	0.492
22	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PDXK(2), PDXP(1), PSAT1(1)	3151763	11	11	11	0	2	1	0	6	2	0	0.0942	0.0182	0.493
23	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), BHMT(2), CTH(1), DNMT1(21), DNMT3A(12), DNMT3B(2), MARS(2), MARS2(3), MTAP(2), TAT(1)	13471379	47	42	28	2	3	2	6	10	26	0	0.0300	0.0187	0.493
24	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A2(3), EIF4B(3), EIF4E(1), EIF4G1(3), EIF4G2(3), EIF4G3(3), MKNK1(2), PDK2(2), PIK3CA(10), PIK3R1(2), PPP2CA(1), PTEN(21), RPS6KB1(2), TSC1(1), TSC2(5)	18200218	63	57	58	7	3	11	3	20	24	2	0.0140	0.0192	0.493
25	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(20), RANGAP1(1)	5391270	22	19	16	1	1	6	2	4	9	0	0.0238	0.0219	0.539
26	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(1), AKT2(3), AKT3(1), CDKN2A(3), GRB2(2), GSK3A(1), GSK3B(3), IARS(4), INPP5D(2), PDK1(1), PIK3CA(10), PPP1R13B(3), PTEN(21), RPS6KA1(7), RPS6KB1(2), SHC1(3), SOS1(5), SOS2(3), TEC(5), YWHAB(1)	23615050	82	70	73	10	3	14	7	22	34	2	0.0149	0.0254	0.581
27	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(10), HLA-DRA(1), HLA-DRB1(1), IL4(1)	2419155	14	14	8	2	1	1	1	1	9	1	0.768	0.0262	0.581
28	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(2), DNMT1(21), MTNR1B(1), PTAFR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), TBXA2R(2)	6746905	34	33	19	4	1	3	3	7	20	0	0.426	0.0264	0.581
29	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3E(1), CD3G(2), CD4(10), CREBBP(5), CSK(3), GNAS(5), GNB1(2), HLA-DRA(1), HLA-DRB1(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTPRC(6)	14449478	46	40	40	2	4	3	2	20	16	1	0.0124	0.0345	0.709
30	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3E(1), CD3G(2), CD4(10), CREBBP(5), CSK(3), GNAS(5), GNB1(2), HLA-DRA(1), HLA-DRB1(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTPRC(6)	14449478	46	40	40	2	4	3	2	20	16	1	0.0124	0.0345	0.709
31	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FOS(1), FYN(2), JUN(2), MAPK14(1), THBS1(11)	4734833	17	15	14	1	1	2	2	6	6	0	0.133	0.0357	0.709
32	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(1), CD3G(2), CD4(10), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6)	7370757	29	26	23	3	1	3	2	10	12	1	0.268	0.0391	0.736
33	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(7), CCNE1(1), CCNE2(2), CDK2(2), CDK4(6), CDKN2A(3), E2F1(1), PRB1(6)	5784289	28	21	16	2	0	1	3	2	22	0	0.260	0.0394	0.736
34	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(4), CPS1(4), GLS(3), GOT1(3)	5133932	15	15	15	1	0	3	1	6	5	0	0.175	0.0412	0.747
35	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(6), ACO1(4), ACSS1(2), ACSS2(7), IDH1(2), IDH2(5), MDH1(1), SUCLA2(1)	8812773	28	23	24	2	1	5	3	8	10	1	0.0484	0.0582	0.996
36	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(1), CALM2(1), GNAS(5), GNB1(2), NFKB1(1), NOS3(2), NPPA(1), PIK3CA(10), PIK3R1(2), RELA(5), SYT1(1)	11513017	33	32	27	3	1	10	1	12	8	1	0.0460	0.0585	0.996
37	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), CASP9(1), CHUK(1), GHR(1), NFKB1(1), PIK3CA(10), PIK3R1(2), PPP2CA(1), RELA(5)	9326040	23	23	17	0	0	8	1	7	6	1	0.00343	0.0598	0.996
38	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(5), GNB1(2), PRKACA(1), PRKAR1A(2)	4071859	12	12	12	1	1	1	0	9	1	0	0.287	0.0634	1.000
39	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(4)	3459591	11	11	11	2	1	1	1	4	3	1	0.531	0.0646	1.000
40	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(1)	1757669	6	6	6	1	1	0	2	0	3	0	0.569	0.0673	1.000
41	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(18), MAP2(4), PPP2CA(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAR2B(2), PRKCE(2)	12102647	35	33	32	3	4	2	2	13	13	1	0.0464	0.0692	1.000
42	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(1), AKT2(3), AKT3(1), BRD4(4), CBL(2), CDC42(1), CDKN2A(3), F2RL2(1), FLOT2(1), GRB2(2), GSK3A(1), GSK3B(3), INPPL1(2), IRS1(4), IRS4(1), LNPEP(2), MAPK3(1), PARD3(5), PDK1(1), PIK3CA(10), PIK3CD(1), PIK3R1(2), PTEN(21), PTPN1(1), RAF1(1), RPS6KA1(7), RPS6KB1(2), SHC1(3), SORBS1(1), SOS1(5), SOS2(3), YWHAB(1)	37359333	97	81	86	8	7	14	12	25	37	2	0.000266	0.0756	1.000
43	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(4), AKT1(1), AKT2(3), AKT3(1), APAF1(2), ATM(15), BID(1), BIRC2(2), BIRC3(2), CAPN1(1), CAPN2(2), CASP10(2), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), CSF2RB(1), DFFB(1), FAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(3), IRAK4(1), NFKB1(1), NFKB2(1), NTRK1(5), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RELA(5), RIPK1(1), TNFRSF10C(1), TNFRSF1A(1), TNFSF10(6), TP53(15), TRADD(2), TRAF2(1)	54726124	136	105	122	12	9	22	13	49	40	3	1.51e-05	0.0780	1.000
44	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(9), MAP3K1(5), MAPK14(1), NCOR2(6), RARA(4), THRA(1)	11146341	30	26	28	2	2	4	5	8	11	0	0.0288	0.0805	1.000
45	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(3), GPI(3), HK1(5), PFKL(1), PGK1(3), TPI1(1)	5888375	19	18	17	2	3	2	2	4	8	0	0.150	0.0835	1.000
46	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), CREM(1), FHL5(2), FSHR(2), GNAS(5), XPO1(5)	6080934	17	17	17	2	3	1	3	7	3	0	0.226	0.0939	1.000
47	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), MPO(4), PRDX1(1), PRDX5(1), TPO(4), TYR(5)	6283322	17	16	17	1	0	2	3	7	5	0	0.0918	0.0965	1.000
48	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3E(1), CD3G(2), CD86(1), CTLA4(1), GRB2(2), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(1), PIK3CA(10), PIK3R1(2), PTPN11(1)	8302598	26	26	22	3	1	7	2	8	8	0	0.153	0.112	1.000
49	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(5), HADHA(2)	3225085	9	9	8	0	1	3	2	1	2	0	0.0459	0.113	1.000
50	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(1), ACADS(3), ECHS1(2), HADHA(2)	3565989	8	8	7	0	3	1	3	1	0	0	0.0479	0.120	1.000
51	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), ADRB2(2), GNAS(5), PLCE1(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RAP2B(2)	9420366	22	22	22	2	3	1	2	9	7	0	0.147	0.129	1.000
52	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(6), CPT1A(1), LEP(1), LEPR(1), PRKAA2(4), PRKAB1(1), PRKAG1(4), PRKAG2(4)	9711466	22	22	19	1	1	4	4	3	10	0	0.0146	0.129	1.000
53	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CD4(10), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(1)	3343993	14	14	8	2	0	2	1	1	9	1	0.816	0.131	1.000
54	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(2)	778537	3	3	3	0	0	0	1	1	1	0	0.585	0.138	1.000
55	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(2), EGF(4), EGFR(9), GRB2(2), HRAS(1), MAPK3(1), PTPRB(3), RAF1(1), RASA1(3), SHC1(3), SOS1(5), SPRY1(1), SPRY2(2), SPRY4(10), SRC(1)	16509407	48	39	39	4	5	11	5	10	17	0	0.0164	0.139	1.000
56	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(1), MMP2(6), MMP9(1), RECK(1), TIMP3(4)	4896566	14	13	11	1	2	2	1	3	6	0	0.201	0.170	1.000
57	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), GLI2(4), GLI3(5), GSK3B(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), SHH(1), SMO(3), SUFU(1)	10138090	27	26	25	3	5	3	2	10	7	0	0.0575	0.190	1.000
58	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(9), ERBB3(4), NRG1(1), UBE2D1(2)	6806238	20	20	18	3	3	1	2	6	8	0	0.353	0.191	1.000
59	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), CASP9(1), CDC42(1), CHUK(1), ELK1(1), HRAS(1), MAPK3(1), NFKB1(1), PIK3CA(10), PIK3R1(2), RAF1(1), RALA(2), RALBP1(1), RELA(5)	12565092	29	29	22	2	1	9	1	9	8	1	0.0291	0.193	1.000
60	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(5), HADH(1), HADHA(2), SIRT1(3), SIRT5(1), SIRT7(2), VNN2(1)	7846258	17	16	16	1	3	4	3	2	5	0	0.0309	0.195	1.000
61	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6)	6954807	20	18	20	2	1	3	2	9	5	0	0.144	0.202	1.000
62	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), FPGS(2)	3825796	12	11	12	2	1	3	1	6	1	0	0.241	0.207	1.000
63	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), GSS(1), NFKB1(1), NOX1(6), RELA(5), XDH(5)	6455005	19	16	14	1	1	2	3	4	8	1	0.149	0.223	1.000
64	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(2), EHHADH(5), GCDH(3), HADHA(2), SDHB(1)	5173720	13	13	10	0	1	3	3	1	5	0	0.0336	0.225	1.000
65	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(2), IFNGR2(2), JAK1(4), JAK2(5), STAT1(3)	5533825	16	16	16	3	1	0	2	6	7	0	0.562	0.233	1.000
66	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(2), AASS(4)	4697753	10	10	10	0	0	2	1	3	4	0	0.160	0.236	1.000
67	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(1), CDC25B(1), CDC25C(2), MNAT1(1), SHH(1), XPO1(5)	5730976	12	12	12	1	0	1	4	6	1	0	0.151	0.240	1.000
68	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ECHS1(2), EHHADH(5), HADHA(2), HADHB(3)	5572378	12	12	11	0	1	4	3	2	2	0	0.0187	0.242	1.000
69	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(3), GLS2(4)	2902056	7	7	7	0	0	1	0	5	1	0	0.273	0.243	1.000
70	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(1), ARPC2(8), CDC42(1), WASL(6)	5343040	16	16	10	2	0	2	0	5	9	0	0.260	0.247	1.000
71	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(5), EP300(11), NCOA3(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RARA(4)	13385859	33	31	30	3	3	1	7	13	9	0	0.0207	0.259	1.000
72	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(2), AASS(4)	3196928	7	7	7	0	0	1	1	2	3	0	0.273	0.271	1.000
73	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HRAS(1), PTK2B(3), SHC1(3), SOS1(5), SRC(1)	5690638	15	13	15	2	1	5	1	5	3	0	0.252	0.274	1.000
74	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(4), GNA12(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAR2B(2)	6577458	15	15	15	2	2	2	3	5	3	0	0.189	0.275	1.000
75	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(4), CDKN2A(3), E2F1(1), PIK3CA(10), PIK3R1(2), POLR1A(4), POLR1B(2), POLR1C(2), RB1(2), TP53(15)	12935489	45	41	40	6	1	10	2	15	15	2	0.0404	0.278	1.000
76	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE3A(1)	6888798	13	13	13	1	1	2	1	5	4	0	0.163	0.288	1.000
77	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(2), AKT1(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(5), GRB2(2), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(10), PIK3R1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), RPS6KA1(7), RPS6KA5(1), SOS1(5)	18932386	52	50	45	6	5	11	3	21	11	1	0.0305	0.291	1.000
78	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(3), ABCB4(5), ABCC1(8), ABCC3(7)	9684385	27	21	21	2	1	3	5	7	11	0	0.0589	0.292	1.000
79	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2)	3778160	8	8	7	1	1	0	0	5	2	0	0.569	0.306	1.000
80	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(1), CD3G(2), ICAM1(1), ITGAL(5), ITGB2(1), PRF1(1)	5356831	13	12	13	1	0	3	2	4	4	0	0.142	0.307	1.000
81	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	481049	1	1	1	0	0	0	1	0	0	0	0.751	0.311	1.000
82	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), ADRB2(2), CFTR(4), GNAS(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	8295712	21	21	21	3	3	2	0	11	5	0	0.317	0.314	1.000
83	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(1), GLS(3), OAT(1), PRODH(1)	3619832	7	7	7	0	0	1	3	2	1	0	0.148	0.316	1.000
84	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(3), LUM(1)	2353850	7	7	7	2	0	1	0	4	2	0	0.683	0.319	1.000
85	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS2(1), DHRSX(5), PON3(4), RDH11(3)	5824116	15	14	10	1	1	0	3	4	7	0	0.363	0.321	1.000
86	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(1), AKT2(3), AKT3(1), CDC42(1), CDK2(2), CDKN2A(3), CREB5(2), ERBB4(6), F2RL2(1), GAB1(1), GRB2(2), GSK3A(1), GSK3B(3), INPPL1(2), IRS1(4), IRS4(1), MET(6), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PARD3(5), PDK1(1), PIK3CA(10), PIK3CD(1), PPP1R13B(3), PREX1(6), PTEN(21), PTK2(1), PTPN1(1), RPS6KA1(7), RPS6KB1(2), SHC1(3), SOS1(5), SOS2(3), TSC1(1), TSC2(5), YWHAB(1)	49096208	128	102	116	16	10	18	9	40	48	3	0.00305	0.321	1.000
87	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(7), CR2(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6)	9718536	24	23	24	3	1	2	1	12	8	0	0.275	0.326	1.000
88	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(1), IKBKB(1), IL4(1), JUN(2), MAP3K1(5), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(1), RELA(5), TNFRSF9(1), TNFSF9(1), TRAF2(1)	13014003	30	26	27	3	0	4	1	11	13	1	0.224	0.344	1.000
89	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(3), C1S(16), C2(4), C3(6), C5(5), C6(1), C7(3), C8A(1)	11483685	40	31	25	5	3	5	1	17	13	1	0.0911	0.346	1.000
90	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), HPRT1(1), IMPDH1(1), POLB(1), POLD1(6), POLG(4), PRPS2(3), RRM1(2)	8012839	19	18	17	2	2	4	1	5	7	0	0.162	0.349	1.000
91	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(2), GLB1(5), GNS(1), GUSB(5), HEXA(3), IDS(2), IDUA(1), LCT(2), NAGLU(2)	9307263	24	21	24	3	2	3	3	9	7	0	0.0919	0.349	1.000
92	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ6(1), NDUFA13(2)	2720684	5	5	5	0	2	1	0	1	1	0	0.218	0.351	1.000
93	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	1021533	2	2	2	1	0	0	0	1	1	0	0.880	0.367	1.000
94	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), FOS(1), JUN(2), MAPK3(1), POLR2A(8), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	8295387	21	20	21	3	6	2	2	6	5	0	0.134	0.379	1.000
95	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB6(1), NDUFS1(5), NDUFS2(1), NDUFV1(1), NDUFV2(1)	4638002	12	12	12	2	0	1	1	7	3	0	0.529	0.381	1.000
96	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(4), EGF(4), EGFR(9), GRB2(2), MET(6), PDGFRA(5), PRKCA(2), SH3GLB1(2), SH3GLB2(1), SH3KBP1(1), SRC(1)	12895146	39	36	36	5	3	5	4	13	14	0	0.130	0.397	1.000
97	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), NFKB1(1), RELA(5)	8256148	19	18	16	2	0	4	1	6	7	1	0.183	0.402	1.000
98	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(2), SHMT1(2), SHMT2(3)	2637325	7	7	7	2	0	1	1	2	3	0	0.687	0.403	1.000
99	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(2), MPO(4), PRDX1(1), PRDX5(1), SHMT1(2), SHMT2(3), TPO(4)	7662500	20	19	20	3	0	3	4	7	6	0	0.240	0.406	1.000
100	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), IDH1(2), IDH2(5), MDH1(1), SDHB(1), SUCLA2(1)	5926418	14	13	11	2	1	2	1	5	5	0	0.368	0.408	1.000
101	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(1), CAMK1G(3), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(2), CAMKK2(2), SYT1(1)	7576560	15	15	14	0	1	1	2	6	5	0	0.0570	0.411	1.000
102	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(1), ENO3(2), GOT1(3), GOT2(2), PAH(3), TAT(1), YARS(1)	5536066	16	14	16	3	2	1	4	3	6	0	0.376	0.414	1.000
103	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), MAP2K3(2), MAP3K1(5), MAPK14(1), MAPK3(1), NFKB1(1), PIK3CA(10), PIK3R1(2), RB1(2), RELA(5), SP1(2)	12998076	32	31	26	4	1	9	1	11	9	1	0.0894	0.418	1.000
104	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(1), ENPP3(1), NADSYN1(1), NMNAT2(2), NNMT(1), NNT(6), NT5M(2), QPRT(1)	9614289	22	22	22	3	1	2	3	12	4	0	0.165	0.419	1.000
105	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(4), GBA(2), GGT1(2), SHMT1(2), SHMT2(3)	3581936	13	13	10	4	0	1	1	3	8	0	0.720	0.424	1.000
106	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	1107719	2	2	2	1	0	1	0	1	0	0	0.763	0.443	1.000
107	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(1), RDH11(3)	3085748	6	6	6	0	1	0	1	4	0	0	0.235	0.445	1.000
108	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG7(4), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), PIK3C3(2), PIK3R4(4), PRKAA2(4), ULK1(1), ULK2(1), ULK3(3)	13894331	31	29	28	3	2	2	1	16	10	0	0.122	0.447	1.000
109	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(6), CS(2), MDH1(1), ME1(1), PC(3), PDHA1(1), SLC25A11(1)	6003931	15	15	15	2	1	3	0	6	5	0	0.204	0.456	1.000
110	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(5), DAXX(5), HRAS(1), PAX3(1), PML(2), RARA(4), RB1(2), SIRT1(3), SP100(1), TNFRSF1A(1), TP53(15)	12015404	40	35	38	6	5	3	5	13	12	2	0.0947	0.476	1.000
111	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(15), ATR(7), CDC25C(2), CHEK2(1), TP53(15)	10758508	40	35	38	7	1	5	3	12	17	2	0.402	0.489	1.000
112	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(5), GNB1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2)	6151940	17	16	17	3	2	2	0	9	4	0	0.417	0.490	1.000
113	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(1), CD3G(2), IL2RA(2), IL4(1), TGFB2(1), TGFBR2(1), TGFBR3(3), TOB1(2), TOB2(3)	7049851	17	17	17	3	1	2	4	4	6	0	0.336	0.495	1.000
114	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR171(1), GPR39(1), GPR45(3), GPR65(3), GPR75(1)	6370681	10	10	10	1	1	2	0	4	2	1	0.0882	0.501	1.000
115	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(2), GLB1(5), GNS(1), GUSB(5), HEXA(3), HGSNAT(1), HPSE(1), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), NAGLU(2), SPAM1(6)	13332496	37	31	37	5	4	6	4	15	8	0	0.0359	0.519	1.000
116	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB1A(2), RAB3A(1), RAB4A(1), RAB5A(1)	2793408	5	5	5	0	1	0	1	1	2	0	0.222	0.523	1.000
117	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(3), C1S(16), C2(4), C3(6), C5(5), C6(1), C7(3), C8A(1), MASP1(2), MASP2(1), MBL2(1)	14029008	44	35	29	6	5	6	1	18	13	1	0.0685	0.524	1.000
118	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(1), ALDOB(3), TPI1(1)	2534776	5	5	5	3	0	0	1	0	4	0	0.993	0.534	1.000
119	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR2(1), ARPC2(8), NCK1(1), NCKAP1(1), NTRK1(5), WASF2(2), WASF3(2), WASL(6)	9986316	26	23	19	3	0	2	1	11	12	0	0.192	0.534	1.000
120	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1B(1), BMPR2(5)	4067154	9	7	9	0	0	1	2	4	2	0	0.0715	0.537	1.000
121	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), FOS(1), GRB2(2), HRAS(1), IL3(1), JAK2(5), MAPK3(1), PTPN6(3), RAF1(1), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2)	11441752	28	26	27	4	4	3	3	10	8	0	0.175	0.542	1.000
122	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(3), GPRC5A(1), GPRC5B(2), GPRC5C(1), GRM1(4), GRM2(2), GRM3(3), GRM4(3), GRM5(7), GRM7(4), GRM8(2)	12621622	37	31	34	5	4	5	3	14	11	0	0.136	0.545	1.000
123	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(3), C1S(16), C2(4), C3(6), C5(5), C6(1), C7(3), C8A(1), C8B(1), MASP1(2)	13681391	43	34	28	6	6	5	1	17	13	1	0.0812	0.557	1.000
124	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(2), ATM(15), CCNE1(1), CDK2(2), CDK4(6), CDKN1A(1), E2F1(1), PCNA(2), RB1(2), TIMP3(4), TP53(15)	12080368	51	35	43	7	1	5	5	10	28	2	0.189	0.563	1.000
125	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(2)	1497521	3	3	3	1	0	0	1	0	2	0	0.902	0.568	1.000
126	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), IFNAR1(2), IFNB1(2), NFKB1(1), RELA(5), TRAF6(2)	7067516	13	13	10	1	1	5	0	1	5	1	0.250	0.581	1.000
127	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(3), UXS1(1)	2648399	4	4	4	1	0	1	2	1	0	0	0.620	0.585	1.000
128	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(2), ATM(15), ATR(7), BID(1), CASP8(1), CASP9(1), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(2), CCNG2(1), CD82(3), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CHEK2(1), FAS(1), GTSE1(2), IGFBP3(1), PTEN(21), RCHY1(1), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(2), THBS1(11), TP53(15), TP53I3(4), TP73(3), TSC2(5)	42330430	129	94	120	19	6	18	12	30	59	4	0.0135	0.586	1.000
129	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), ITGB1(4), KLRC1(2), KLRC2(3), KLRC3(1), MAPK3(1), PAK1(2), PIK3CA(10), PIK3R1(2), PTK2B(3), PTPN6(3), SYK(1), VAV1(3)	12279664	37	33	33	6	2	9	3	10	13	0	0.152	0.587	1.000
130	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1), HLA-DRB1(1), IL3(1)	1780309	3	3	3	0	0	0	0	0	3	0	0.826	0.588	1.000
131	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(3), UGP2(1), UXS1(1)	3354142	5	5	5	1	0	1	3	1	0	0	0.488	0.592	1.000
132	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1)	2183565	4	4	4	1	0	0	0	2	2	0	0.892	0.605	1.000
133	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), AKT1(1), AKT2(3), AKT3(1), ARHGAP1(1), ARHGEF11(5), CDC42(1), CFL1(1), GDI2(1), INPPL1(2), ITPR1(4), ITPR2(9), ITPR3(4), LIMK1(4), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDK1(1), PIK3CA(10), PIK3CD(1), PIK3CG(3), PIK3R1(2), PITX2(2), PPP1R13B(3), PTEN(21), RACGAP1(1), RHO(1), ROCK1(4), ROCK2(2), SAG(5), WASL(6)	46030110	117	93	111	14	6	22	10	36	42	1	0.000496	0.612	1.000
134	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(1), CDK2(2), CUL1(3), E2F1(1), RB1(2), SKP2(1)	5788222	17	17	14	3	0	2	2	2	11	0	0.357	0.612	1.000
135	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), EIF4E(1), FBL(1), GPT(2), LDHB(1), LDHC(3), MAPK14(1), NCL(3)	5863439	17	15	16	4	0	0	4	6	7	0	0.682	0.615	1.000
136	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(3), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1)	6720053	14	12	14	2	0	3	2	5	4	0	0.266	0.627	1.000
137	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), GRB2(2), HRAS(1), MAPK3(1), MAPK7(1), MEF2D(1), NTRK1(5), PIK3CA(10), PIK3R1(2), PLCG1(2), RPS6KA1(7), SHC1(3)	12412009	36	34	27	5	4	7	1	13	10	1	0.148	0.629	1.000
138	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(10), CD8A(1), IL3(1), IL4(1)	3900358	13	13	7	3	0	2	1	1	8	1	0.887	0.632	1.000
139	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(3), AKT3(1), BRAF(2), EIF4B(3), FIGF(1), HIF1A(3), MAPK3(1), PGF(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRKAA2(4), RHEB(3), RICTOR(4), RPS6KA1(7), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), TSC1(1), TSC2(5), ULK1(1), ULK2(1), ULK3(3), VEGFC(2)	34531290	77	71	63	7	6	12	6	28	22	3	0.00194	0.642	1.000
140	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	FOSB(1), GRIA2(3), PPP1R1B(1)	2312513	5	5	5	2	1	1	0	3	0	0	0.748	0.645	1.000
141	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(2), HADH(1), HADHA(2), HADHB(3), MECR(1)	5555699	9	8	9	0	1	2	3	3	0	0	0.0521	0.647	1.000
142	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(2), CASP8(1), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	5178481	9	9	9	2	0	3	3	2	1	0	0.405	0.648	1.000
143	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), IDI1(1), IDI2(1)	2908836	5	5	5	1	0	0	0	2	3	0	0.831	0.656	1.000
144	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAP3K1(5), MAPK3(1), PIK3CA(10), PIK3R1(2), RAF1(1), SOS1(5), STAT1(3), STAT5A(2), STAT5B(2)	18108538	43	42	39	6	3	9	4	20	7	0	0.0561	0.660	1.000
145	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(1), CFLAR(1)	2545277	3	3	3	1	0	0	2	0	1	0	0.770	0.662	1.000
146	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	10437781	19	19	19	2	3	0	0	8	8	0	0.140	0.666	1.000
147	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(1)	1058489	1	1	1	1	0	0	1	0	0	0	0.943	0.666	1.000
148	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNA1(1), IFNB1(2), IKBKB(1), IL1B(1), IL1R1(1), IL1RAP(4), IRAK1(3), IRAK3(3), JUN(2), MAP2K3(2), MAP3K1(5), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TGFB2(1), TRAF6(2)	19456804	37	34	33	3	3	10	0	12	11	1	0.0228	0.670	1.000
149	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD2(1), GGT1(2)	3696433	5	5	5	1	0	0	2	1	2	0	0.469	0.672	1.000
150	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(6), FADS2(2), FASN(3), HADHA(2), PECR(1)	9051181	18	17	15	3	3	2	4	5	4	0	0.169	0.679	1.000
151	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CTH(1), GGT1(2), MARS(2), MARS2(3), PAPSS1(2), PAPSS2(2), SCLY(2), SEPHS1(1)	7909012	16	16	16	3	2	0	5	4	5	0	0.314	0.680	1.000
152	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK14(1), NFKB1(1), RELA(5), TNFRSF13B(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(2)	9546530	16	15	13	1	0	4	0	6	5	1	0.183	0.692	1.000
153	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CTH(1), MUT(2)	3173931	4	4	4	0	1	0	1	0	2	0	0.468	0.694	1.000
154	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CA(10), PIK3CD(1), PIK3R1(2), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(2)	21095269	38	36	35	3	5	9	2	18	4	0	0.00271	0.700	1.000
155	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(2), STX1A(1), VAMP2(1)	2113258	4	4	4	3	0	0	0	1	3	0	0.986	0.705	1.000
156	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1070228	1	1	1	0	0	0	0	1	0	0	0.838	0.711	1.000
157	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), GLCE(1), HS2ST1(1), HS3ST2(1), HS3ST5(1), HS6ST1(1), HS6ST2(1), NDST1(2), NDST2(3), NDST4(5)	13199599	31	29	25	3	2	4	3	8	14	0	0.0596	0.712	1.000
158	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(1), ITGAL(5), ITGAM(5), ITGB2(1), SELE(4)	6986089	18	18	18	4	0	6	2	4	6	0	0.285	0.713	1.000
159	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDK2(2), CUL1(3), E2F1(1), NEDD8(2), RB1(2), SKP2(1)	5746773	12	12	11	2	0	1	1	2	8	0	0.519	0.714	1.000
160	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(6), IL3(1), KITLG(2), TGFB2(1)	5477520	11	11	11	2	0	1	1	4	5	0	0.608	0.714	1.000
161	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLRMT(2)	8545476	20	19	18	3	1	4	4	3	8	0	0.193	0.719	1.000
162	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(4), EIF2B5(2), EIF2S2(2), EIF5(2), GSK3B(3)	7634764	15	14	13	2	0	1	2	4	8	0	0.425	0.733	1.000
163	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(4), EGFR(9), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(4), JUN(2), MAP3K1(5), MAPK3(1), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2)	24617467	66	59	59	10	6	13	5	21	21	0	0.0848	0.734	1.000
164	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	1344260	3	3	3	2	0	2	0	1	0	0	0.868	0.735	1.000
165	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(1), AKT2(3), AKT3(1), GRB2(2), GSK3A(1), GSK3B(3), IL4R(2), IRS1(4), JAK1(4), JAK3(3), MAP4K1(1), MAPK3(1), PDK1(1), PIK3CA(10), PIK3CD(1), PIK3R1(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(5), SOS2(3), STAT6(4)	22819697	59	52	54	9	6	13	9	20	11	0	0.0243	0.743	1.000
166	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(4), ATM(15), ATR(7), CCNA1(7), CCNE1(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), E2F1(1), GSK3B(3), HDAC1(2), RB1(2), SKP2(1), TGFB2(1), TP53(15)	19775709	72	56	62	12	1	9	6	17	37	2	0.151	0.756	1.000
167	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ICAM1(1), ITGA4(2), ITGAL(5), ITGB1(4), ITGB2(1), SELE(4)	8049451	19	18	19	4	0	5	3	5	6	0	0.325	0.762	1.000
168	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(15), CDC25A(1), CDC25B(1), CDC25C(2), CDK2(2), CDK4(6), MYT1(2), RB1(2), TP53(15), WEE1(1)	11800521	47	37	42	8	1	5	5	13	21	2	0.268	0.765	1.000
169	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), ATIC(2), FTCD(2), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(1), SHMT1(2), SHMT2(3)	12548008	22	21	22	3	3	4	0	10	5	0	0.181	0.770	1.000
170	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), DHRSX(5), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3)	9596586	18	17	14	1	1	2	2	5	8	0	0.213	0.772	1.000
171	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(4), ANKRD1(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(2), WDR1(1)	7034714	11	11	11	2	0	3	2	3	3	0	0.387	0.779	1.000
172	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2)	2037938	2	2	2	1	0	1	0	1	0	0	0.891	0.784	1.000
173	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IFNGR1(2), IFNGR2(2), IKBKB(1), JAK2(5), NFKB1(1), RB1(2), RELA(5), TNFRSF1A(1), TP53(15), USH1C(3), WT1(3)	11741949	41	35	36	7	1	5	3	9	20	3	0.345	0.784	1.000
174	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C5(5), C6(1), C7(3), C8A(1)	8544986	16	16	16	3	2	2	1	8	3	0	0.325	0.785	1.000
175	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDKN1A(1), NEK1(3), WEE1(1)	4906037	7	6	7	1	0	2	0	3	2	0	0.447	0.795	1.000
176	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(2), IFNGR2(2), IL12RB1(2), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(2)	8183213	18	17	18	4	4	1	1	5	7	0	0.531	0.799	1.000
177	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(2), JAK1(4), JAK2(5), PTPRU(4), STAT1(3)	7501440	18	16	18	4	2	0	2	9	5	0	0.570	0.800	1.000
178	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(5), RPE(1), UCHL3(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2)	11577235	25	22	25	4	2	5	3	5	10	0	0.253	0.802	1.000
179	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	AGT(1), AKT1(1), CALM2(1), CALR(1), CAMK1(1), CAMK1G(3), CAMK4(1), CREBBP(5), CSNK1A1(2), ELSPBP1(1), F2(2), GATA4(2), GSK3B(3), HRAS(1), MAPK14(1), MAPK3(1), MYH2(9), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NPPA(1), PIK3CA(10), PIK3R1(2), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RAF1(1), RPS6KB1(2), SYT1(1)	32539613	81	67	73	8	7	10	6	26	32	0	0.00187	0.805	1.000
180	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(2), CASP9(1), DAXX(5), FAS(1), HSPB2(2), MAPKAPK2(1)	7180948	12	12	12	2	2	1	0	7	2	0	0.359	0.807	1.000
181	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(4), ARHGDIB(1), CASP1(2), CASP10(2), CASP8(1), CASP9(1), JUN(2), PRF1(1)	8351688	16	15	16	3	0	3	1	7	5	0	0.481	0.807	1.000
182	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), AP2A1(2), BIN1(1), CALM2(1), DNM1(1), EPN1(1), EPS15(1), PICALM(1), PPP3CA(2), PPP3CC(3), SYNJ1(5), SYNJ2(5), SYT1(1)	14557266	27	27	27	4	1	6	1	12	7	0	0.166	0.808	1.000
183	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), ATIC(2), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(1), SHMT1(2), SHMT2(3)	11867713	20	19	20	3	3	4	0	8	5	0	0.224	0.809	1.000
184	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(9)	10720371	26	23	24	3	2	0	0	11	13	0	0.315	0.811	1.000
185	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(1), ACADS(3), ACSL1(2), ACSL3(13), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(5), HADHA(2), PECR(1), SCP2(2)	11117341	32	28	20	6	2	5	6	14	5	0	0.117	0.811	1.000
186	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), RPN1(2), RPN2(1), UBE2A(2), UBE3A(1)	8767774	17	17	17	3	0	1	2	8	6	0	0.577	0.814	1.000
187	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(2), FDPS(1), IDI1(1), LSS(2), MVK(1), PMVK(1), VKORC1(1)	7266876	11	11	11	1	0	0	1	7	3	0	0.460	0.814	1.000
188	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCNE1(1), CDK2(2), CDK4(6), CDKN1A(1), E2F1(1), HRAS(1), MAPK3(1), NFKB1(1), PAK1(2), PIK3CA(10), PIK3R1(2), RAF1(1), RB1(2), RELA(5)	13308701	37	32	28	5	1	8	3	10	14	1	0.143	0.816	1.000
189	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(7), AXIN1(2), BTRC(2), CREBBP(5), CSNK1A1(2), CTBP1(1), CTNNB1(1), DVL1(1), FZD1(1), GSK3B(3), HDAC1(2), MAP3K7(1), PPARD(1), PPP2CA(1), TLE1(4), WIF1(4)	18971371	38	34	32	3	2	2	5	14	15	0	0.0177	0.817	1.000
190	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(3), AKT3(1), CD19(1), CDKN2A(3), FLOT2(1), GAB1(1), ITPR1(4), ITPR2(9), ITPR3(4), PDK1(1), PIK3CA(10), PITX2(2), PLCG2(2), PPP1R13B(3), PREX1(6), PTEN(21), PTPRC(6), RPS6KA1(7), RPS6KB1(2), SAG(5), SYK(1), TEC(5), VAV1(3)	36400706	102	89	95	16	7	18	10	29	36	2	0.00956	0.826	1.000
191	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(1), HSD3B1(1)	5329177	6	6	6	0	1	1	2	2	0	0	0.138	0.832	1.000
192	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(1), CSNK1A1(2), GSK3B(3), MAPT(3), PPP2CA(1)	6119567	10	10	8	0	0	1	1	1	7	0	0.108	0.835	1.000
193	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(3), AOC3(1), CES1(7)	3671618	11	11	9	3	0	1	1	4	5	0	0.640	0.844	1.000
194	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(7), AXIN1(2), CTNNB1(1), DVL1(1), FZD1(1), GNAI1(1), GSK3B(3), IRAK1(3), LBP(1), LEF1(1), LY96(1), NFKB1(1), PIK3CA(10), PIK3R1(2), PPP2CA(1), RELA(5), TLR4(2)	19541154	44	44	36	6	1	11	5	14	12	1	0.0302	0.844	1.000
195	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1), SPCS1(1)	2028703	2	2	2	1	0	0	0	1	1	0	0.869	0.847	1.000
196	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(5), ALAS2(3), CPOX(5), FECH(2), PPOX(1), UROD(1)	5062066	17	17	12	6	0	0	3	6	8	0	0.893	0.851	1.000
197	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(2), MPO(4), MTHFR(1), SHMT1(2), SHMT2(3), TPO(4)	7542016	19	18	19	4	0	3	3	7	6	0	0.440	0.852	1.000
198	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(5), F13A1(1), F2(2), FGA(2), FGB(1), FGG(5), PLAT(4), PLG(5)	8931892	25	23	20	5	1	0	4	10	10	0	0.399	0.854	1.000
199	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), GRB2(2), IL4(1), IL4R(2), IRS1(4), JAK1(4), JAK3(3), RPS6KB1(2), SHC1(3), STAT6(4)	9209886	26	24	26	5	4	3	4	8	7	0	0.294	0.855	1.000
200	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	ELK1(1), FOS(1), GRB2(2), HRAS(1), INSR(4), IRS1(4), JUN(2), MAPK3(1), PIK3CA(10), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(3), SHC1(3), SOS1(5)	16234316	41	38	36	7	5	12	3	14	7	0	0.0932	0.860	1.000
201	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), IL4(1), JUNB(1), MAF(1), MAP2K3(2), MAPK14(1), NFATC1(2), NFATC2(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	7255388	23	22	21	5	4	0	1	10	8	0	0.439	0.864	1.000
202	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(5), NFKB1(1), RELA(5), TRAF3(1), TRAF6(2)	12025983	18	16	15	1	0	5	0	3	9	1	0.108	0.867	1.000
203	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	1350624	1	1	1	1	0	0	0	1	0	0	0.940	0.867	1.000
204	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(5), EP300(11), IKBKB(1), NFKB1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF6(2)	14388684	30	26	24	4	1	4	6	5	13	1	0.165	0.869	1.000
205	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(3), HDAC9(2), MEF2D(1)	5358220	7	7	6	1	1	0	0	2	4	0	0.614	0.873	1.000
206	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(5), FYN(2), LRP8(4), RELN(5), VLDLR(2)	9287001	18	17	13	2	1	3	0	4	10	0	0.530	0.875	1.000
207	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(15), ATR(7), BRCA1(5), CDC25A(1), CDC25B(1), CDC25C(2), CDKN1A(1), CHEK2(1), EP300(11), MYT1(2), PRKDC(10), RPS6KA1(7), TP53(15), WEE1(1)	28513136	79	62	70	11	2	9	8	29	28	3	0.0480	0.880	1.000
208	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1)	8806978	16	16	13	3	1	1	0	7	7	0	0.654	0.885	1.000
209	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), FAH(1), GOT1(3), GOT2(2), HGD(2), MAOA(1), TAT(1), TH(2), TPO(4), TYR(5)	20485286	56	49	52	10	5	4	7	20	20	0	0.243	0.886	1.000
210	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(5), EP300(11), LPL(2), NCOA1(2), NCOA2(9), PPARG(2)	12108595	31	23	22	4	2	1	4	8	16	0	0.0951	0.886	1.000
211	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(4), PCYT1A(1), PDHA1(1), PDHA2(2), SLC18A3(1)	4258777	10	10	8	3	0	2	0	2	6	0	0.887	0.889	1.000
212	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), GBGT1(2), GLA(1), HEXA(3), ST3GAL1(1), ST8SIA1(2)	6814216	10	10	10	2	1	2	1	5	1	0	0.313	0.889	1.000
213	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(5), AGT(1), AGTR1(2), BDKRB2(1), KNG1(2), NOS3(2), REN(1)	6220091	14	13	12	3	1	3	1	3	6	0	0.454	0.889	1.000
214	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDK2(2), CUL1(3), E2F1(1), FBXW7(2), RB1(2)	5632778	11	11	11	3	0	1	1	2	7	0	0.709	0.891	1.000
215	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(4), POLR1B(2), POLR1C(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1)	15491738	34	31	32	4	1	5	3	14	11	0	0.0927	0.893	1.000
216	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(2), FDFT1(2), FDPS(1), HMGCS1(1), IDI1(1), LSS(2), MVK(1), NSDHL(3), PMVK(1)	8670732	14	12	14	1	0	2	1	7	4	0	0.244	0.896	1.000
217	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), CREBBP(5), DFFB(1), PRF1(1)	6823412	9	8	9	0	2	1	2	2	2	0	0.0619	0.897	1.000
218	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(1), ARRB2(1), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA1(1), CLCA4(2), CNGA3(3), CNGA4(2), CNGB1(6), PDC(1), PDE1C(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKG1(3), PRKG2(2)	20348083	36	34	33	4	5	5	2	14	10	0	0.0703	0.899	1.000
219	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CFL1(1), CHN1(2), LIMK1(4), MAP3K1(5), MYL2(1), MYLK(4), NCF2(1), PAK1(2), PDGFRA(5), PIK3CA(10), PIK3R1(2), PLD1(2), PPP1R12B(1), RALBP1(1), RPS6KB1(2), TRIO(2), VAV1(3)	23141692	48	45	43	5	1	7	3	20	17	0	0.0541	0.900	1.000
220	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(1), EPHB1(1), FYN(2), ITGA1(5), ITGB1(4), L1CAM(5), SELP(2)	10345754	20	19	19	4	2	2	2	8	6	0	0.367	0.900	1.000
221	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25B(1), CDC25C(2), CSK(3), GRB2(2), PRKCA(2), PTPRA(3), SRC(1)	6030235	15	13	15	4	0	5	1	6	3	0	0.505	0.903	1.000
222	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), GBA(2), MPO(4), TPO(4)	5410392	12	11	12	3	0	2	2	4	4	0	0.510	0.905	1.000
223	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), RDH5(2)	2542945	4	4	4	2	0	0	2	1	1	0	0.861	0.908	1.000
224	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFB(1), TOP2A(4), TOP2B(1)	6729138	7	7	7	0	2	1	0	2	2	0	0.240	0.909	1.000
225	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACADM(1), ACADS(3), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOX1(7), BCAT1(1), BCKDHA(1), DLD(2), ECHS1(2), EHHADH(5), HADH(1), HADHA(2), HADHB(3), HIBADH(1), HMGCS1(1), HMGCS2(1), IVD(2), MCCC1(2), MCCC2(3), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(3)	28556934	54	52	50	6	4	6	11	18	15	0	0.0190	0.914	1.000
226	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ECHS1(2), EHHADH(5), HADHA(2)	7977735	17	17	14	4	1	4	3	3	6	0	0.456	0.915	1.000
227	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(2), PAPSS2(2), SULT2A1(1), SUOX(4)	4078790	9	9	9	3	1	0	3	1	4	0	0.701	0.919	1.000
228	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CASP2(1), CHUK(1), IKBKB(1), JUN(2), LTA(1), MAP2K3(2), MAP3K1(5), MAPK14(1), NFKB1(1), RELA(5), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	15660452	28	25	25	4	1	4	2	11	9	1	0.305	0.920	1.000
229	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(2), CDC25C(2), GNAI1(1), GNAS(5), GNB1(2), HRAS(1), MAPK3(1), MYT1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RPS6KA1(7), SRC(1)	13011651	32	30	28	5	5	2	0	16	8	1	0.260	0.921	1.000
230	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), NDUFA1(1), SDHA(1), SDHB(1), SDHD(1), UQCRC1(1)	4300772	7	6	7	2	1	2	1	3	0	0	0.532	0.921	1.000
231	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), CHRNB1(2), MUSK(1), PIK3CA(10), PIK3R1(2), PTK2(1), PTK2B(3), SRC(1), TERT(5)	10697791	26	24	23	5	2	11	1	8	4	0	0.178	0.922	1.000
232	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), GCNT2(2), ST8SIA1(2)	3802567	5	5	5	2	1	1	1	2	0	0	0.646	0.923	1.000
233	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CD28(1), CD4(10), CXCR4(1), IFNGR1(2), IFNGR2(2), IL12RB1(2), IL12RB2(2), IL18R1(1), IL4(1), IL4R(2), TGFB2(1)	13175511	26	25	20	4	4	2	2	6	11	1	0.380	0.925	1.000
234	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(10), HLA-DRA(1), HLA-DRB1(1), IFNA1(1), IFNB1(2), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(1)	8368491	20	19	14	4	0	4	1	4	10	1	0.719	0.926	1.000
235	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(7), CCND2(1), CCNE1(1), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), E2F1(1), RB1(2)	10455994	27	24	21	6	0	1	3	6	17	0	0.582	0.927	1.000
236	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(5), KHK(3), LCT(2), MPI(1), PYGL(1), PYGM(3), TPI1(1)	8882163	16	15	16	3	4	0	3	6	3	0	0.278	0.927	1.000
237	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), ATF2(1), CDC42(1), DLD(2), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), IL1R1(1), JUN(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K11(1), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAP3K9(3), MAPK10(1), MAPK7(1), MAPK9(2), NFATC3(5), NR2C2(1), PAPPA(1), SHC1(3), TP53(15), TRAF6(2), ZAK(3)	32617384	81	69	76	12	6	10	9	30	24	2	0.0353	0.928	1.000
238	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(7), AR(1), ASAH1(1), BRAF(2), EGFR(9), GNA15(1), GNAI1(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), KCNJ3(3), MAPK10(1), MAPK14(1), PHKA2(3), PIK3CA(10), PIK3CD(1), PIK3R1(2), PITX2(2), RAF1(1), SRC(1)	34879153	67	52	62	7	8	15	10	24	9	1	0.000558	0.928	1.000
239	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNB1(2), JAK1(4), STAT1(3), STAT2(6), TYK2(6)	7056471	24	20	23	6	2	5	3	5	9	0	0.427	0.929	1.000
240	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(3)	8497018	16	16	16	4	3	1	1	10	1	0	0.454	0.930	1.000
241	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C5(5), C6(1), C7(3), ICAM1(1), ITGA4(2), ITGAL(5), ITGB1(4), ITGB2(1), SELP(2), SELPLG(2), VCAM1(3)	16371292	35	33	35	7	3	5	5	15	7	0	0.181	0.933	1.000
242	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	CHST11(1), CHST12(2), PAPSS1(2), PAPSS2(2), SULT1A1(1), SULT2A1(1), SUOX(4)	5671732	13	13	13	4	2	1	3	1	6	0	0.745	0.934	1.000
243	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(2), LCMT1(1), LCMT2(3), PCYT1A(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3)	9072873	15	14	15	2	1	2	1	6	5	0	0.481	0.935	1.000
244	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	2272771	1	1	1	1	0	0	0	0	1	0	0.967	0.936	1.000
245	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(1), CAMK1G(3), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), MEF2D(1), PPP3CA(2), PPP3CC(3), SYT1(1)	13416740	17	17	16	1	2	1	1	5	8	0	0.116	0.936	1.000
246	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(2), PPARG(2), RETN(1)	3623001	5	5	5	2	1	1	0	1	2	0	0.732	0.936	1.000
247	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(6)	6769437	18	18	17	5	1	0	3	6	8	0	0.830	0.936	1.000
248	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(6)	6769437	18	18	17	5	1	0	3	6	8	0	0.830	0.936	1.000
249	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1)	5547482	11	11	11	3	0	1	1	5	4	0	0.847	0.939	1.000
250	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA2(1), GLB1(5), HEXA(3), LCT(2), MAN2C1(5), MANBA(1), NEU1(1)	10318615	19	18	19	4	1	3	2	10	3	0	0.366	0.939	1.000
251	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), MIOX(2)	5551696	9	9	7	2	0	2	0	1	6	0	0.742	0.940	1.000
252	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(2), PDE1A(1), PDE1B(5), PLCB1(1), PLCB2(2), TRH(8)	7190204	19	17	12	9	3	2	0	3	11	0	0.986	0.940	1.000
253	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), TH(2), TPH1(1)	3765718	5	5	5	2	1	1	1	1	1	0	0.762	0.941	1.000
254	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(1), GRIN1(2), GRIN2A(6), GRIN2B(6), NOS1(9), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), SYT1(1)	16559708	41	36	40	8	7	7	1	19	7	0	0.147	0.942	1.000
255	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(3), CTH(1), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(1), LDHC(3), MPST(2), SULT1B1(2), SULT1C4(1), SULT4A1(1)	8238711	26	26	24	6	2	1	2	9	12	0	0.742	0.943	1.000
256	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), ITPKB(2)	3678919	3	3	3	0	1	1	0	0	1	0	0.298	0.944	1.000
257	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(1), PER1(4)	5502413	8	8	7	2	0	0	2	2	4	0	0.688	0.945	1.000
258	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT6(2), ST3GAL3(3)	2932945	5	5	4	2	1	1	0	0	3	0	0.882	0.947	1.000
259	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	DHRS2(1), DHRSX(5), ECHS1(2), EHHADH(5), ESCO1(2), ESCO2(1), FN3K(1), GCDH(3), HADHA(2), PNPLA3(2), SH3GLB1(2), YOD1(1)	16967600	27	25	20	2	1	4	3	4	15	0	0.153	0.948	1.000
260	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACADM(1), ACADS(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), AOX1(7), BCAT1(1), BCKDHA(1), ECHS1(2), EHHADH(5), HADHA(2), HADHB(3), HIBADH(1), IVD(2), MCCC1(2), MCCC2(3), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(3)	23862148	49	47	45	7	3	6	10	16	14	0	0.0726	0.950	1.000
261	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(3)	8913722	16	16	16	4	3	1	1	10	1	0	0.451	0.950	1.000
262	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(2), RB1(2), SP1(2), SP3(2)	4473590	8	8	8	3	0	1	0	2	5	0	0.894	0.954	1.000
263	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), DAXX(5), ELK1(1), GRB2(2), HRAS(1), HSPB2(2), MAP3K1(5), MAP3K5(5), MAP3K7(1), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAX(5), MEF2D(1), MKNK1(2), PLA2G4A(1), RIPK1(1), RPS6KA5(1), SHC1(3), STAT1(3), TGFB2(1), TRADD(2), TRAF2(1)	24138594	50	43	48	7	6	5	2	24	13	0	0.0707	0.954	1.000
264	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1R(1)	3807978	3	3	3	1	0	1	0	1	1	0	0.845	0.955	1.000
265	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT2(2), B3GALT5(1), B3GNT5(1), ST3GAL3(3), ST3GAL4(1)	4537861	9	8	8	4	1	0	1	1	6	0	0.938	0.955	1.000
266	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), DDC(2), EPX(2), GOT1(3), GOT2(2), MAOA(1), MPO(4), PRDX1(1), PRDX5(1), TAT(1), TPO(4)	14132890	33	29	30	5	2	3	8	7	13	0	0.156	0.955	1.000
267	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BRAF(2), CREB5(2), DUSP4(1), DUSP9(1), EEF2K(1), EIF4E(1), GRB2(2), MAPK3(1), MKNK1(2), MKNK2(1), MOS(1), NFKB1(1), RAP1A(1), RPS6KA1(7), SHC1(3), SOS1(5), SOS2(3), TRAF3(1)	19323486	38	35	34	5	4	5	5	13	9	2	0.153	0.956	1.000
268	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), IKBKB(1), LTA(1), MAP3K1(5), NFKB1(1), RELA(5), RIPK1(1), TANK(1), TRAF2(1), TRAF3(1)	14638426	20	17	17	2	1	4	0	5	9	1	0.171	0.956	1.000
269	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(2), AKT1(1), CSF2RB(1), IGF1R(1), IL3(1), KITLG(2), PIK3CA(10), PIK3R1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	14196205	28	28	25	5	5	6	1	11	5	0	0.104	0.956	1.000
270	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A2(3), EIF4E(1), EIF4G1(3), EIF4G2(3), EIF4G3(3), GHR(1), IRS1(4), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(9), PDK2(2), PIK3CA(10), PIK3R1(2), PRKCA(2), PTEN(21), RPS6KB1(2)	18319467	71	62	68	14	7	15	4	23	21	1	0.124	0.956	1.000
271	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ACADM(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOC2(3), AOC3(1), CNDP1(3), DPYD(4), DPYS(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), MLYCD(2), SMS(2), UPB1(1)	17467757	37	33	34	6	2	4	10	7	14	0	0.0761	0.958	1.000
272	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), LDLR(1), LPL(2)	3413036	4	4	4	2	0	2	0	1	1	0	0.732	0.958	1.000
273	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(2), F5(7), F7(1), FGA(2), FGB(1), FGG(5), PROC(3), PROS1(4), TFPI(1)	10725276	26	25	24	6	1	1	1	10	12	1	0.562	0.959	1.000
274	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(2), NR1H4(2)	3365546	5	5	5	2	0	2	0	2	1	0	0.733	0.959	1.000
275	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	DPM2(1), EGR1(9), HRAS(1), MAPK3(1), NGFR(1), RAF1(1)	5216259	14	14	7	4	2	1	0	3	8	0	0.881	0.959	1.000
276	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ICAM1(1), ITGA4(2), ITGAL(5), ITGAM(5), ITGB1(4), ITGB2(1), SELE(4), SELP(2)	10666870	26	24	26	6	0	7	4	7	8	0	0.322	0.960	1.000
277	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(3), AOC3(1), CES1(7), DDHD1(2), ESCO1(2), ESCO2(1), PLA1A(3), PNPLA3(2), SH3GLB1(2)	16430976	24	22	22	2	1	2	1	8	12	0	0.160	0.961	1.000
278	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT3(2), B4GALT5(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1)	5027823	9	9	8	5	1	0	1	1	6	0	0.970	0.963	1.000
279	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), DHCR7(2), FDFT1(2), FDPS(1), GGCX(1), IDI1(1), IDI2(1), LSS(2), MVK(1), NSDHL(3), PMVK(1), TM7SF2(1), VKORC1(1)	12617987	20	18	18	2	0	2	1	8	9	0	0.332	0.966	1.000
280	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(7), CD38(1), ENPP3(1), NADSYN1(1), NMNAT2(2), NMNAT3(2), NNMT(1), NNT(6), NT5C1B(1), NT5C2(1), NT5M(2), NUDT12(2), QPRT(1)	14178712	28	27	28	5	1	3	4	13	7	0	0.294	0.967	1.000
281	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(1), CAT(2), GHR(1), HRAS(1), IGF1R(1), PIK3CA(10), PIK3R1(2), SHC1(3)	8559038	21	20	18	5	2	6	2	8	3	0	0.365	0.969	1.000
282	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), DPM2(1), GRB2(2), HRAS(1), NTRK1(5), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), SHC1(3), SOS1(5)	10114817	34	33	29	8	1	10	2	14	7	0	0.447	0.970	1.000
283	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(15), CDC25A(1), CDC25B(1), CDC25C(2), MYT1(2), WEE1(1)	9173713	22	19	22	5	0	3	2	9	8	0	0.561	0.971	1.000
284	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADM(1), ACADS(3), ACOX1(1), ACOX3(2), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), CPT1A(1), CPT1C(4), CPT2(1), CYP4A11(4), ECHS1(2), EHHADH(5), GCDH(3), HADH(1), HADHA(2), HADHB(3)	32352413	70	57	51	10	5	7	11	25	22	0	0.0355	0.972	1.000
285	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), PNPLA3(2), SH3GLB1(2)	10831774	13	13	9	0	0	1	1	3	8	0	0.266	0.973	1.000
286	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(7), AXIN1(2), BTRC(2), CTNNB1(1), DLL1(1), DVL1(1), FZD1(1), GSK3B(3), NOTCH1(5)	12978526	23	22	20	4	1	3	3	10	6	0	0.269	0.974	1.000
287	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(1), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), PNPLA3(2), SH3GLB1(2)	16469964	23	20	18	2	1	1	1	9	11	0	0.365	0.974	1.000
288	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(3), AASDHPPT(2), AASS(4), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), BBOX1(1), DOT1L(2), ECHS1(2), EHHADH(5), EHMT1(3), EHMT2(3), GCDH(3), HADHA(2), PLOD1(2), PLOD2(4), PLOD3(11), SHMT1(2), SHMT2(3), TMLHE(1)	23315967	62	50	50	9	4	10	6	14	27	1	0.123	0.974	1.000
289	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(1), PRKCA(2), RELA(5)	5442041	9	9	6	4	0	3	0	0	5	1	0.927	0.975	1.000
290	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(2), JAK1(4), PTPRU(4), STAT1(3), STAT2(6), TYK2(6)	8016205	27	23	26	7	3	4	3	8	9	0	0.459	0.975	1.000
291	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	DPM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAPK3(1), NGFR(1), PIK3CA(10), PIK3R1(2), PLCG1(2), RAF1(1), SHC1(3), SOS1(5)	12245002	33	32	29	7	3	9	2	14	5	0	0.332	0.975	1.000
292	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(9), ELK1(1), GNAS(5), GNB1(2), GRB2(2), HRAS(1), IGF1R(1), ITGB1(4), MAPK3(1), MKNK1(2), MKNK2(1), NGFR(1), PDGFRA(5), PPP2CA(1), PTPRR(3), RAF1(1), RPS6KA1(7), RPS6KA5(1), SHC1(3), SOS1(5), SRC(1), STAT3(3)	21388019	61	51	55	12	7	10	5	22	16	1	0.259	0.977	1.000
293	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), CS(2), DLD(2), IDH1(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), PC(3), PCK1(4), SDHA(1), SDHB(1), SUCLA2(1), SUCLG1(5), SUCLG2(2)	13517464	36	32	33	8	2	3	5	15	11	0	0.460	0.977	1.000
294	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD3B1(1)	4396277	5	5	5	2	0	0	1	4	0	0	0.741	0.977	1.000
295	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(9), CANT1(1), DCTD(1), DPYD(4), DPYS(2), DTYMK(1), NT5M(2), POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(9), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLRMT(2), RRM1(2), RRM2(1), TK1(1), TK2(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(1)	37263633	76	58	68	10	3	10	10	20	32	1	0.0222	0.977	1.000
296	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(5), JAK3(3), MAPK3(1), STAT3(3), TYK2(6)	7595297	22	22	21	9	1	0	4	8	9	0	0.962	0.978	1.000
297	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(4), JUN(2), MAP3K1(5), MAPK3(1), PDGFRA(5), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2)	22937485	58	55	53	10	4	12	4	21	17	0	0.154	0.979	1.000
298	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT2(3), AKT3(1), BCL10(1), CARD11(8), CBL(2), CBLB(2), CBLC(1), CD28(1), CD3E(1), CD3G(2), CD4(10), CD8A(1), CDC42(1), CDK4(6), CHUK(1), CTLA4(1), FOS(1), FYN(2), GRAP2(1), GRB2(2), HRAS(1), ICOS(2), IKBKB(1), IL4(1), ITK(1), JUN(2), KRAS(1), LCP2(1), MALT1(1), NCK1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIB(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDK1(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCQ(4), PTPN6(3), PTPRC(6), RASGRP1(2), SOS1(5), SOS2(3), TEC(5), VAV1(3), VAV2(4)	65780591	164	115	146	22	7	24	18	64	50	1	0.00598	0.979	1.000
299	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(2), CD3E(1), CD3G(2), CD4(10), IL12RB1(2), IL12RB2(2), JAK2(5), STAT4(1), TYK2(6)	9673965	31	29	24	7	2	1	3	10	14	1	0.840	0.980	1.000
300	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), AMDHD1(1), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), DDC(2), FTCD(2), HAL(1), HARS(1), HARS2(1), HNMT(1), LCMT1(1), LCMT2(3), MAOA(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), PRPS1(1), PRPS2(3), UROC1(1)	25522496	47	42	44	5	2	10	7	14	14	0	0.0127	0.981	1.000
301	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(1), ACP5(2), ACP6(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP3A7(1), DHRS2(1), DHRSX(5), PON3(4)	11460846	26	25	21	5	1	5	2	9	9	0	0.399	0.982	1.000
302	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), GRB2(2), HRAS(1), IGF1R(1), IRS1(4), MAPK3(1), PIK3CA(10), PIK3R1(2), RAF1(1), SHC1(3), SOS1(5)	12073442	31	29	28	7	5	9	2	12	3	0	0.211	0.983	1.000
303	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(1), TUB(1)	4682284	5	5	5	2	0	0	0	4	1	0	0.848	0.984	1.000
304	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), GOT1(3), GOT2(2), PAH(3), TAT(1), YARS(1)	5743651	11	11	11	4	1	0	2	3	5	0	0.877	0.984	1.000
305	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(5), RPE(1), UGP2(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), XYLB(1)	17938184	39	35	39	7	3	6	6	12	12	0	0.221	0.984	1.000
306	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(1), NFS1(1), THTPA(1)	4262104	4	4	4	2	1	0	1	2	0	0	0.826	0.984	1.000
307	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA2(1), GLB1(5), HEXA(3), LCT(2), MAN2B2(2), MAN2C1(5), MANBA(1), NEU1(1)	12702405	21	19	21	4	1	3	3	11	3	0	0.276	0.984	1.000
308	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15B(2), ALOX5(2), DPEP1(1), GGT1(2), LTA4H(4), PLA2G6(2), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3)	9760650	25	22	23	6	2	4	6	5	7	1	0.410	0.985	1.000
309	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(1), CD3E(1), CD3G(2), ELK1(1), FOS(1), FYN(2), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), PIK3CA(10), PIK3R1(2), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), PTPN7(1), RAF1(1), RASA1(3), RELA(5), SHC1(3), SOS1(5), SYT1(1), VAV1(3)	30766912	78	70	69	14	6	18	6	23	24	1	0.102	0.985	1.000
310	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(1), MAP3K1(5), MAPK3(1), NFKB1(1), NSMAF(3), RAF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	13355727	22	19	19	4	1	4	3	4	9	1	0.260	0.986	1.000
311	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(3), GOT1(3), GOT2(2), GPT(2), GPT2(2), MDH1(1), ME1(1), ME2(2), ME3(2), PGK1(3), RPE(1), TKT(1), TPI1(1)	11637287	25	23	25	6	0	3	5	5	12	0	0.590	0.986	1.000
312	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(5), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(3), C1S(16), C2(4), C3(6), C3AR1(1), C4BPA(3), C4BPB(2), C5(5), C5AR1(2), C6(1), C7(3), C8A(1), C8B(1), C8G(1), CD55(1), CFB(2), CFH(4), CFI(1), CPB2(5), CR1(7), CR2(2), F11(1), F12(3), F13A1(1), F13B(2), F2(2), F5(7), F7(1), F8(5), F9(2), FGA(2), FGB(1), FGG(5), KLKB1(2), KNG1(2), MASP1(2), MASP2(1), MBL2(1), PLAT(4), PLAUR(2), PLG(5), PROC(3), PROS1(4), SERPINA1(2), SERPIND1(2), SERPINF2(2), SERPING1(2), TFPI(1), VWF(11)	58915164	158	109	137	27	13	18	15	67	42	3	0.0101	0.986	1.000
313	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(4), JAK2(5), JAK3(3), PIAS1(4), PIAS3(2), PTPRU(4), SOAT1(4)	8989340	26	22	24	6	1	1	5	9	10	0	0.455	0.987	1.000
314	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ENPP3(1), FLAD1(2), TYR(5)	6339264	12	12	12	4	0	3	0	6	3	0	0.770	0.988	1.000
315	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(6), CLTB(1), COPA(6), GBF1(6), GPLD1(1), KDELR3(2)	10825705	23	22	23	5	1	1	2	11	7	1	0.604	0.988	1.000
316	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), PRKCE(2)	5231754	8	8	8	4	0	0	1	4	3	0	0.939	0.988	1.000
317	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(2), PRKCA(2), PTK2B(3)	4390874	8	8	7	5	0	3	0	1	4	0	0.959	0.989	1.000
318	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(15), BMPR1B(1), CCND2(1), CDK4(6), EGR1(9), ESR2(2), FSHR(2), MLH1(2), NCOR1(4), NRIP1(4), PGR(2), PRLR(2), PTGER2(1), VDR(1), ZP2(2)	22374800	54	46	44	8	4	7	5	13	25	0	0.172	0.990	1.000
319	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(2), JAK1(4), STAT1(3), STAT3(3), STAT5A(2)	7906947	15	15	14	4	1	0	1	5	8	0	0.882	0.990	1.000
320	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CTH(1), GGT1(2), LCMT1(1), LCMT2(3), MARS(2), MARS2(3), PAPSS1(2), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SCLY(2), SEPHS1(1), SEPHS2(2)	15925758	30	29	30	5	3	2	8	9	8	0	0.200	0.991	1.000
321	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT3(2), B4GALT4(2), FUT6(2), GCNT2(2), ST8SIA1(2)	9677693	16	15	16	4	2	4	3	3	4	0	0.423	0.991	1.000
322	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(3), GOT1(3), GOT2(2), GPT(2), GPT2(2), MDH1(1), ME1(1), ME3(2), PGK1(3), RPE(1), TKT(1), TKTL1(1), TKTL2(2), TPI1(1)	13036866	26	25	26	7	0	2	5	6	13	0	0.736	0.992	1.000
323	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAS1(5), ALAS2(3), CPO(1), FECH(2), GATA1(1), HBB(3), UROD(1)	5212363	16	16	14	5	0	1	3	9	3	0	0.698	0.992	1.000
324	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), FURIN(3), NOTCH1(5)	5218392	9	9	7	3	1	1	0	3	4	0	0.883	0.992	1.000
325	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(1), CAPN2(2), EGF(4), EGFR(9), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), MYL2(1), MYLK(4), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTK2(1), PXN(1), TLN1(6)	21454073	48	43	45	9	8	4	3	17	16	0	0.246	0.993	1.000
326	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(6), NRG2(2), NRG3(2), PRKCA(2)	6056416	12	12	12	4	1	3	1	5	2	0	0.681	0.993	1.000
327	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(2), CALCRL(1), CD97(4), CRHR1(1), CRHR2(2), ELTD1(2), EMR1(2), EMR2(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(2), LPHN1(2), LPHN2(3), LPHN3(8), SCTR(1), VIPR1(1)	18037113	39	33	39	8	6	5	4	16	8	0	0.164	0.994	1.000
328	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(3), B3GNT7(1), B4GALT3(2), B4GALT4(2), CHST1(2), CHST2(1), CHST4(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1)	7451397	18	17	17	5	1	3	2	3	9	0	0.703	0.994	1.000
329	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AKR1B10(2), ALAS1(5), ALAS2(3), AOC2(3), AOC3(1), BHMT(2), CHDH(2), CHKB(2), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(1), GLDC(3), GNMT(1), MAOA(1), PHGDH(3), PISD(1), PSAT1(1), RDH11(3), SARDH(3), SARS(2), SHMT1(2), SHMT2(3), TARS(5), TARS2(5)	27800539	63	56	59	11	8	9	10	18	18	0	0.0416	0.994	1.000
330	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(1), PER1(4), PER2(4), PER3(3)	11025602	15	15	13	3	0	1	4	5	5	0	0.441	0.995	1.000
331	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2)	5203296	8	8	6	4	0	1	1	2	4	0	0.963	0.995	1.000
332	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2)	5203296	8	8	6	4	0	1	1	2	4	0	0.963	0.995	1.000
333	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(3), NAT1(1), NAT2(1), XDH(5)	5170152	13	13	13	5	2	1	2	4	4	0	0.860	0.995	1.000
334	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAD9(1), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AKR1B10(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(3), RDH11(3), SLC27A5(2), SOAT1(4), SOAT2(2)	20802444	36	33	31	5	4	2	3	14	13	0	0.184	0.995	1.000
335	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(1), MBTPS1(2), SCAP(1), SREBF1(2), SREBF2(6)	7505675	13	13	13	4	1	3	2	2	5	0	0.681	0.995	1.000
336	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(3), CHIT1(4), CYB5R1(2), CYB5R3(2), GFPT2(1), GNE(1), GNPDA1(1), HEXA(3), HK1(5), MTMR1(1), MTMR2(1), NAGK(2), NANS(2), NPL(5), RENBP(2)	18875362	37	34	34	6	4	4	5	11	13	0	0.0701	0.996	1.000
337	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(3), ACTG2(1), ACTR2(1), AKT1(1), CDC42(1), CFL1(1), FLNA(4), FLNC(5), FSCN1(3), FSCN3(2), GDI2(1), LIMK1(4), MYH2(9), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), RHO(1), ROCK1(4), ROCK2(2), WASL(6)	30169321	66	54	64	11	4	9	2	20	31	0	0.143	0.996	1.000
338	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST12(2), CHST14(1), CHST7(1), CHSY1(8), DSE(1), XYLT1(2), XYLT2(2)	7901368	22	20	16	5	2	5	0	5	10	0	0.517	0.996	1.000
339	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA2B(1), P2RY1(1), P2RY2(1)	3573278	4	4	4	5	0	1	0	2	1	0	0.974	0.996	1.000
340	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(4), DDX20(4), E2F1(1), ETS1(1), ETS2(1), FOS(1), HRAS(1), JUN(2), NCOR2(6), RBL2(2), SIN3A(1), SIN3B(1)	16981032	25	23	25	4	2	2	1	10	10	0	0.324	0.996	1.000
341	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(1), BDKRB2(1), CALM2(1), CHRNA1(2), FLT1(7), FLT4(7), KDR(5), NOS3(2), PDE2A(1), PDE3A(3), PDE3B(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKG1(3), PRKG2(2), RYR2(11), SLC7A1(1), SYT1(1), TNNI1(2)	26966845	59	55	59	10	10	10	6	19	14	0	0.0382	0.996	1.000
342	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), DDC(2), HAL(1), HARS(1), HNMT(1), MAOA(1), PRPS1(1), PRPS2(3)	15828919	31	30	28	6	1	6	6	8	10	0	0.207	0.996	1.000
343	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(7), AXIN1(2), CREBBP(5), CTNNB1(1), DVL1(1), EP300(11), FZD1(1), GSK3B(3), HDAC1(2), LDB1(1), LEF1(1), PITX2(2), TRRAP(8)	21404191	45	39	37	6	1	2	8	17	17	0	0.0964	0.997	1.000
344	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(2), IDH2(5), MDH1(1), OGDH(3), SDHA(1), SUCLA2(1)	6227804	13	12	10	5	0	3	0	5	5	0	0.906	0.997	1.000
345	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), ECH1(2), ESCO1(2), ESCO2(1), FAH(1), GOT1(3), GOT2(2), HGD(2), LCMT1(1), LCMT2(3), MAOA(1), PNPLA3(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SH3GLB1(2), TAT(1), TH(2), TPO(4), TYR(5), TYRP1(1)	38483713	79	66	75	12	6	7	10	29	27	0	0.0859	0.997	1.000
346	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(1), EGR2(1), EGR3(1), MAP3K1(5), NFATC1(2), NFATC2(5), NFKB1(1), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RELA(5), SYT1(1)	17766085	38	34	32	6	4	5	0	10	18	1	0.250	0.997	1.000
347	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(5), CD19(1), CD1A(1), CD1B(1), CD1C(1), CD1D(2), CD1E(2), CD2(2), CD22(4), CD33(1), CD34(2), CD38(1), CD3E(1), CD3G(2), CD4(10), CD44(2), CD55(1), CD8A(1), CR1(7), CR2(2), CSF1R(4), CSF2RA(2), CSF3R(2), DNTT(4), FLT3(6), HLA-DRA(1), HLA-DRB1(1), IL11RA(1), IL1B(1), IL1R1(1), IL1R2(4), IL2RA(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL9R(2), ITGA1(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGAM(5), ITGB3(1), KITLG(2), MME(5), MS4A1(1), TFRC(2), TPO(4)	53253971	125	85	111	22	6	11	13	39	55	1	0.249	0.997	1.000
348	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), EGFR(9), IGF1R(1), POLR2A(8), PPP2CA(1), PRKCA(2), RB1(2), TEP1(4), TERT(5), TNKS(4), TP53(15), XRCC5(3)	18382141	55	42	51	12	7	10	5	13	18	2	0.142	0.997	1.000
349	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1), PRKCA(2)	3139352	3	3	3	2	0	1	0	1	1	0	0.914	0.998	1.000
350	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), DDC(2), EPX(2), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), MAOA(1), MPO(4), PNPLA3(2), SH3GLB1(2), TAT(1), TPO(4)	22080165	38	35	35	5	2	4	7	9	16	0	0.108	0.998	1.000
351	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(2), ARHGEF1(2), F2(2), GNA12(1), GNA13(4), GNAI1(1), GNB1(2), MAP3K7(1), PIK3CA(10), PIK3R1(2), PLCB1(1), PPP1R12B(1), PRKCA(2), PTK2B(3), ROCK1(4)	16828076	38	37	35	8	2	8	2	18	8	0	0.243	0.998	1.000
352	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(7), CALM2(1), CAMK1(1), CAMK1G(3), IGF1R(1), INSR(4), MAPK14(1), MAPK7(1), MEF2D(1), NFATC1(2), NFATC2(5), PIK3CA(10), PIK3R1(2), PPP3CA(2), PPP3CC(3), SYT1(1)	22207763	46	42	38	8	4	9	3	14	16	0	0.124	0.998	1.000
353	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BRAF(2), CREB5(2), RAF1(1), SNX13(2), SRC(1)	7645801	9	6	9	3	0	3	1	4	0	1	0.687	0.998	1.000
354	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(2), JAK1(4), JAK2(5), JAK3(3), PIAS3(2), PTPRU(4), SRC(1), STAT3(3)	9856128	24	21	24	9	1	2	3	9	9	0	0.920	0.998	1.000
355	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(2), CHUK(1), DAXX(5), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(1), JUN(2), MAP2K3(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K11(1), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP3K9(3), MAP4K1(1), MAP4K3(4), MAP4K4(2), MAP4K5(4), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK7(1), MAPK9(2), MAPKAPK2(1), MAX(5), MEF2D(1), MKNK1(2), MKNK2(1), NFKB1(1), PAK1(2), PAK2(2), RAF1(1), RELA(5), RIPK1(1), RPS6KA1(7), RPS6KA4(1), RPS6KA5(1), RPS6KB1(2), RPS6KB2(2), SHC1(3), SP1(2), STAT1(3), TGFB2(1), TRADD(2), TRAF2(1)	62711428	123	88	114	16	14	13	7	43	43	3	0.0113	0.998	1.000
356	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(2), AASS(4), AKR1B10(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), BBOX1(1), DOT1L(2), ECHS1(2), EHHADH(5), EHMT1(3), EHMT2(3), GCDH(3), HADH(1), HADHA(2), NSD1(8), OGDH(3), OGDHL(2), PLOD1(2), PLOD2(4), PLOD3(11), RDH11(3), SETD1A(4), SETD7(1), SETDB1(4), SHMT1(2), SHMT2(3), SPCS1(1), SUV39H2(4), TMLHE(1)	37046209	91	69	78	17	6	15	11	23	35	1	0.174	0.998	1.000
357	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), CYP2C19(1), DHRS2(1), DHRSX(5), ECHS1(2), EHHADH(5), ESCO1(2), ESCO2(1), HADHA(2), PNPLA3(2), SH3GLB1(2), YOD1(1)	20234780	31	28	24	4	1	5	3	6	16	0	0.260	0.998	1.000
358	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(6), ACO1(4), CLYBL(2), CS(2), DLD(2), IDH1(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), OGDH(3), OGDHL(2), PC(3), PCK1(4), PCK2(1), SDHA(1), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(5), SUCLG2(2)	19614320	51	44	48	11	3	7	5	21	15	0	0.349	0.999	1.000
359	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL4(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(2)	3499094	8	8	8	4	0	2	1	4	1	0	0.742	0.999	1.000
360	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(4), DPYS(2), ENPP3(1), PANK1(2), PANK2(4), PANK3(1), PANK4(1), UPB1(1)	9047276	18	17	18	5	1	2	3	7	5	0	0.554	0.999	1.000
361	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(1), CAMK2D(1), CAMK2G(2), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), NFAT5(6), PDE6A(1), PDE6B(3), PDE6C(2), SLC6A13(2)	23627157	37	34	37	6	5	4	7	14	7	0	0.0867	0.999	1.000
362	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(10), PIK3R1(2), PLCB1(1), PLCG1(2), PRKCA(2), VAV1(3)	8540621	21	21	17	8	1	7	2	5	6	0	0.732	0.999	1.000
363	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(2), BID(1), BIRC2(2), BIRC3(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), FAS(1), JUN(2), MAP3K1(5), MAPK10(1), NFKB1(1), PARP1(3), PRF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TNFSF10(6), TP53(15), TRADD(2), TRAF2(1)	24064447	56	43	48	11	1	10	6	15	21	3	0.204	0.999	1.000
364	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(3), AKT3(1), GRB2(2), IARS(4), IL13RA1(1), IL4(1), IL4R(2), INPP5D(2), JAK1(4), JAK2(5), JAK3(3), PIK3CA(10), PPP1R13B(3), RPS6KB1(2), SHC1(3), SOS1(5), SOS2(3), SRC(1), STAT6(4), TYK2(6)	23899296	66	56	62	13	2	13	12	23	16	0	0.156	0.999	1.000
365	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), AOC2(3), AOC3(1), CNDP1(3), DPYD(4), DPYS(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), MLYCD(2), SMS(2), UPB1(1)	18839524	38	34	35	8	2	4	11	8	13	0	0.178	0.999	1.000
366	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(4), ATM(15), BRCA1(5), CDKN1A(1), CHEK2(1), JUN(2), MRE11A(1), NFKB1(1), RAD50(4), RAD51(2), RELA(5), TP53(15), TP73(3)	19442110	59	50	54	11	2	10	5	19	20	3	0.282	0.999	1.000
367	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(7), CDH1(1), CREBBP(5), EP300(11), MAP3K7(1), MAPK3(1), SKIL(1), TGFB2(1), TGFBR2(1)	16947697	29	27	26	5	2	2	7	10	8	0	0.148	0.999	1.000
368	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1)	4779260	5	5	5	3	0	1	0	3	1	0	0.950	0.999	1.000
369	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(7), ATF2(1), AXIN1(2), BMP10(1), BMP2(1), BMP4(1), BMP5(1), BMP7(3), BMPR2(5), CHRD(3), CTNNB1(1), DVL1(1), FZD1(1), GATA4(2), GSK3B(3), MAP3K7(1), MYL2(1), NPPA(1), NPPB(1), RFC1(4), TGFB2(1), TGFBR2(1), TGFBR3(3)	23282567	47	41	45	7	4	5	4	20	14	0	0.0720	0.999	1.000
370	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(2), ALOX5(2), CBR1(2), CYP4F2(2), EPX(2), GGT1(2), LTA4H(4), MPO(4), PLA2G4A(1), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3), TPO(4)	17956538	39	36	37	8	3	6	9	10	10	1	0.207	0.999	1.000
371	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(4), DBH(2), DDC(2), GAD2(1), MAOA(1), PAH(3), SLC18A3(1), TH(2), TPH1(1)	8959575	18	17	16	7	1	3	3	4	7	0	0.873	0.999	1.000
372	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), ATF2(1), CALM2(1), EGFR(9), ELK1(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), MEF2D(1), PAK1(2), PRKCA(2), PTK2(1), PTK2B(3), RAF1(1), SHC1(3), SOS1(5), SRC(1), SYT1(1)	22267611	46	39	44	9	6	11	4	15	10	0	0.207	0.999	1.000
373	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(5), EP300(11), FYN(2), JAK1(4), JAK3(3), PIK3CA(10), PIK3R1(2), PTK2B(3), STAT5A(2), STAT5B(2)	18354788	44	39	37	9	1	8	8	14	13	0	0.224	0.999	1.000
374	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(2), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), ASL(4), ASNS(1), ASPA(1), ASRGL1(4), ASS1(2), CAD(9), CRAT(1), DARS(1), DARS2(1), DLAT(2), DLD(2), GAD2(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), NARS2(4), PC(3), PDHA1(1), PDHA2(2), PDHB(1)	24693317	57	44	50	10	2	5	11	13	25	1	0.175	0.999	1.000
375	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(1), PSMD11(3), PSMD13(2), PSMD2(5), PSMD6(1)	10694207	24	21	23	6	1	3	3	6	11	0	0.624	0.999	1.000
376	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BCL2A1(2), CASP1(2), CASP10(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), DAXX(5), DFFB(1), FAS(1), IKBKE(1), LTA(1), NFKB1(1), NGFR(1), NTRK1(5), PTPN13(7), RIPK1(1), TFG(2), TNFRSF1A(1), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2)	28439569	45	40	44	7	3	8	3	22	9	0	0.101	0.999	1.000
377	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	CAD(9), CASP10(2), CASP8(1), CSNK1A1(2), DAXX(5), DEDD(1), EGFR(9), EPHB2(2), FAF1(1), FAIM2(1), MAP2K7(1), MAP3K1(5), MAP3K5(5), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(6), NFAT5(6), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PTPN13(7), RALBP1(1), RIPK1(1), ROCK1(4), TP53(15), TPX2(1), TRAF2(1)	47567384	98	79	89	15	10	8	7	40	30	3	0.0438	0.999	1.000
378	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(1), JUN(2), KEAP1(2), MAPK14(1), NFE2L2(7), PRKCA(2)	5598849	15	15	15	6	1	3	2	7	2	0	0.768	0.999	1.000
379	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2E1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2I(3), GTF2IRD1(1), STON1(2), TAF1(5), TAF1L(6), TAF2(5), TAF4(5), TAF4B(5), TAF5(2), TAF5L(2), TAF6(1), TAF7(1), TAF7L(5), TAF9B(1)	23845446	53	47	49	10	4	7	6	18	18	0	0.157	0.999	1.000
380	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(1), ADCY8(8), CACNA1A(5), CACNA1B(4), GNAS(5), GNB1(2), GNB3(2), GNG3(1), GRM4(3), ITPR3(4), KCNB1(1), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(2), PRKACG(2), SCNN1A(2), SCNN1B(2), SCNN1G(2), TAS1R2(3), TAS1R3(2), TAS2R13(1), TAS2R3(14), TAS2R38(2), TAS2R39(1), TAS2R42(1), TAS2R43(2), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(1)	36868061	85	66	75	15	14	6	7	39	19	0	0.0813	0.999	1.000
381	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP68(2), SRP72(2), SRP9(1)	5035886	6	6	6	3	0	2	0	3	1	0	0.825	0.999	1.000
382	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	GBGT1(2), GLA(1), HEXA(3), ST3GAL1(1), ST3GAL4(1), ST8SIA1(2)	6422822	10	10	10	4	0	2	1	5	2	0	0.646	0.999	1.000
383	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(1), APOBEC3B(1), APOBEC4(1)	4821591	9	8	9	6	2	0	2	4	1	0	0.943	0.999	1.000
384	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), ATF1(2), CDC42(1), CREB5(2), DUSP10(1), EEF2K(1), EIF4E(1), ELK1(1), IL1R1(1), MAP2K3(2), MAP3K10(3), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(2), MKNK2(1), NFKB1(1), NR2C2(1), TRAF6(2)	21858948	38	36	38	7	2	9	0	21	6	0	0.174	1.000	1.000
385	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(2), BIRC3(2), CASP10(2), CASP7(1), CASP8(1), CASP9(1), DFFB(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(6)	11618458	22	21	22	5	1	5	2	6	8	0	0.425	1.000	1.000
386	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), NCOA1(2), NCOA2(9), NCOA3(5), NCOR2(6), POLR2A(8), RARA(4), TBP(1)	16358051	39	31	33	9	1	5	5	9	19	0	0.387	1.000	1.000
387	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(1), AKT2(3), AKT3(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(3), PITX2(2), PLD1(2), PLD2(5), PLD3(3)	28922609	48	38	46	7	6	9	8	14	11	0	0.0181	1.000	1.000
388	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(5)	6631308	5	4	5	5	2	0	0	1	2	0	0.972	1.000	1.000
389	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(1), ELK1(1), FOS(1), IKBKB(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(2), MAP3K1(5), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TLR10(2), TLR2(2), TLR4(2), TLR6(1), TLR7(3), TLR9(1), TRAF6(2)	23441123	38	34	34	6	2	8	1	13	13	1	0.179	1.000	1.000
390	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(2), FYN(2), GNAI1(1), GNB1(2), GRB2(2), HRAS(1), JAK2(5), MAPK14(1), MAPK3(1), MAPT(3), MYLK(4), PLCG1(2), PRKCA(2), PTK2B(3), RAF1(1), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2), SYT1(1)	27480771	55	48	53	10	4	9	6	21	15	0	0.187	1.000	1.000
391	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(1), SNCAIP(2), UBE2E2(1)	4184639	5	5	5	3	0	3	1	0	1	0	0.829	1.000	1.000
392	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLB(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLG(4), POLG2(4), POLH(4), POLI(3), POLK(3), POLL(2), POLM(3), POLQ(9), PRIM1(2), PRIM2(2), REV1(2), REV3L(12), RFC5(1)	27198763	65	52	59	12	4	4	3	32	22	0	0.341	1.000	1.000
393	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), GREB1(11), HSPB2(2), MTA1(1), MTA3(2)	6796750	17	16	15	6	0	1	2	10	4	0	0.895	1.000	1.000
394	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(1), ADSL(1), AGXT(1), ASL(4), ASNS(1), ASPA(1), CAD(9), CRAT(1), DARS(1), GAD2(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), PC(3)	16996699	35	31	31	7	1	3	9	4	17	1	0.420	1.000	1.000
395	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10060370	18	17	18	6	0	2	4	6	6	0	0.774	1.000	1.000
396	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10060370	18	17	18	6	0	2	4	6	6	0	0.774	1.000	1.000
397	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10060370	18	17	18	6	0	2	4	6	6	0	0.774	1.000	1.000
398	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(5), CD44(2), IL1B(1), IL6R(2), SPN(1), TGFB2(1), TNFRSF1A(1)	8490160	13	13	11	4	2	4	0	1	6	0	0.691	1.000	1.000
399	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(6), ACACB(4), ACADM(1), ACSS1(2), ACSS2(7), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), ECHS1(2), EHHADH(5), HADHA(2), LDHAL6B(1), LDHB(1), LDHC(3), MCEE(1), MLYCD(2), MUT(2), PCCA(1), PCCB(3), SUCLA2(1), SUCLG1(5), SUCLG2(2)	26298582	59	49	54	12	3	7	15	13	20	1	0.198	1.000	1.000
400	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(5), IMPA2(3)	7466458	8	7	8	6	3	0	0	2	3	0	0.970	1.000	1.000
401	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(5), EP300(11), MAPK3(1), PELP1(1), SRC(1)	9572843	19	16	16	7	2	1	4	5	7	0	0.789	1.000	1.000
402	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(1), B4GALT3(2), B4GALT5(1), DPAGT1(5), DPM1(1), MAN1A1(2), MGAT4A(3), MGAT4B(1), MGAT5(3), RPN1(2), RPN2(1)	12592340	24	24	24	7	0	6	0	9	9	0	0.645	1.000	1.000
403	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(8), CASP1(2), CASP7(1), CASP8(1), GAPDH(2), INSR(4), ITCH(1), MAGI1(3), MAGI2(4), RERE(4), WWP2(3)	15438477	33	29	24	8	5	2	3	8	13	2	0.788	1.000	1.000
404	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BCL10(1), BID(1), CASP9(1), CES1(7)	7571865	12	12	10	4	0	1	0	6	5	0	0.867	1.000	1.000
405	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ACADS(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), SDHB(1)	16974815	29	28	25	6	4	5	6	5	9	0	0.227	1.000	1.000
406	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(15), ATR(7), BRCA1(5), BRCA2(7), CHEK2(1), FANCA(4), FANCE(2), FANCF(2), FANCG(3), HUS1(2), MRE11A(1), RAD17(1), RAD50(4), RAD51(2), TP53(15), TREX1(2)	29412454	73	61	71	12	3	13	7	27	21	2	0.134	1.000	1.000
407	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), GLB1(5), HEXA(3), LCT(2), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	10442846	23	21	23	6	1	4	2	10	6	0	0.399	1.000	1.000
408	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), FUCA2(1), GALNS(2), GBA(2), GLB1(5), GNS(1), GUSB(5), HEXA(3), HGSNAT(1), HPSE(1), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), MAN2B2(2), MAN2C1(5), MANBA(1), NAGLU(2), NEU1(1), SPAM1(6)	21861110	50	42	50	10	5	8	6	21	10	0	0.108	1.000	1.000
409	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(3), G6PD(2), GPI(3), PFKM(3), PFKP(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RPE(1), TALDO1(1), TKT(1)	12977377	23	22	21	8	1	4	4	4	10	0	0.821	1.000	1.000
410	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CALR(1), CANX(1), CD4(10), CD74(1), CD8A(1), CIITA(3), CTSB(3), CTSS(1), HLA-B(1), HLA-C(2), HLA-DPA1(1), HLA-DPB1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(1), HLA-E(2), HLA-F(1), HSP90AA1(4), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), KIR2DL3(1), KIR3DL1(3), KIR3DL3(1), KLRC1(2), KLRC2(3), KLRC3(1), LTA(1), NFYC(2), RFX5(2), RFXAP(1), TAP2(1)	27085430	72	56	65	15	2	8	7	29	25	1	0.608	1.000	1.000
411	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GNE(1), GNPDA1(1), HEXA(3), HK1(5), RENBP(2)	11123051	14	13	14	5	2	0	2	4	6	0	0.743	1.000	1.000
412	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(1), EDNRB(3), EGF(4), EGFR(9), FOS(1), HRAS(1), JUN(2), NFKB1(1), PLCG1(2), PRKCA(2), RELA(5)	13362042	33	29	27	8	4	4	3	10	11	1	0.604	1.000	1.000
413	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10593136	18	17	18	6	0	2	4	6	6	0	0.771	1.000	1.000
414	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(5), CD2(2), CD33(1), IFNA1(1), IFNB1(2), IL3(1), IL4(1), ITGAX(3), TLR2(2), TLR4(2), TLR7(3), TLR9(1)	11884722	24	23	23	9	2	4	4	7	7	0	0.810	1.000	1.000
415	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(5), EP300(11), IKBKB(1), IL1B(1), MAP2K3(2), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TGFBR2(1), TLR2(2)	19371642	32	28	26	5	1	3	4	10	13	1	0.288	1.000	1.000
416	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(2), CASP7(1), CASP8(1), CFLAR(1), DAXX(5), DFFB(1), FAF1(1), JUN(2), LMNB1(3), MAP3K1(5), MAP3K7(1), PAK1(2), PAK2(2), PRKDC(10), PTPN13(7), RB1(2), RIPK2(2), SPTAN1(6)	28042411	55	47	55	9	3	6	6	21	19	0	0.0927	1.000	1.000
417	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(1), IL1R1(1), IRAK1(3), MAP3K1(5), MAP3K7(1), NFKB1(1), RELA(5), RIPK1(1), TLR4(2), TNFRSF1A(1), TRADD(2), TRAF6(2)	15645914	26	23	23	6	1	7	2	4	11	1	0.457	1.000	1.000
418	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(7), ASAH1(1), CERK(5), CREB5(2), EPHB2(2), FOS(1), ITPKB(2), JUN(2), MAP2K7(1), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2)	17965013	31	28	28	6	5	4	3	11	8	0	0.262	1.000	1.000
419	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), MAPK8IP3(1), PAPPA(1), RPS6KA1(7), SHC1(3), SOS1(5), SYK(1), VAV1(3), VAV2(4)	20598662	39	34	35	8	5	6	3	14	10	1	0.290	1.000	1.000
420	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(5), G6PD(2), GCLC(1), GGT1(2), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), IDH1(2), IDH2(5)	11898082	21	18	18	8	0	2	5	5	9	0	0.928	1.000	1.000
421	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(8), ABCC2(1), BCHE(2), CES1(7), CES2(2), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3)	15191546	32	25	27	7	2	3	4	9	14	0	0.580	1.000	1.000
422	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(6), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ECHS1(2), EHHADH(5), HADHA(2), LDHB(1), LDHC(3), MCEE(1), MLYCD(2), MUT(2), PCCA(1), PCCB(3), SUCLA2(1), SUCLG1(5), SUCLG2(2)	21966427	46	42	42	10	3	5	11	12	15	0	0.258	1.000	1.000
423	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(1), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(2), PIGO(4), PIGP(1), PIGQ(3), PIGT(6), PIGU(1), PIGV(1), PIGZ(3)	15947146	32	30	28	8	1	4	4	12	10	1	0.643	1.000	1.000
424	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1)	5903596	6	6	6	3	0	0	1	5	0	0	0.813	1.000	1.000
425	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1)	5903596	6	6	6	3	0	0	1	5	0	0	0.813	1.000	1.000
426	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ASAH1(1), ATF1(2), BRAF(2), CREB5(2), CREBBP(5), EGR1(9), EGR2(1), EGR3(1), ELK1(1), FRS2(2), JUN(2), MAP1B(7), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(5), PIK3C2G(2), PIK3CA(10), PIK3CD(1), PIK3R1(2), PTPN11(1), SHC1(3), SRC(1), TH(2)	32906311	73	60	61	15	8	15	3	24	22	1	0.190	1.000	1.000
427	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IL15(1), IL16(4), IL3(1), IL4(1), LTA(1)	6394068	11	11	11	5	0	4	1	5	1	0	0.786	1.000	1.000
428	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(2), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GPHN(1), SRC(1), UBQLN1(2)	7898767	11	11	11	5	0	3	2	4	2	0	0.838	1.000	1.000
429	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(2), BID(1), BIK(1), BIRC2(2), BIRC3(2), CASP7(1), CASP8(1), CASP9(1), DFFB(1)	8930987	12	12	12	5	0	2	1	5	4	0	0.815	1.000	1.000
430	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(1), DPYD(4), DPYS(2), ENPP3(1), ILVBL(2), PANK1(2), PANK2(4), PANK3(1), PANK4(1), UPB1(1), VNN1(1)	11219940	21	20	21	8	1	3	3	8	6	0	0.798	1.000	1.000
431	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK3(1), NFKB1(1), PLCB1(1), PRKCA(2), RAF1(1), RELA(5)	9892034	17	17	14	6	4	3	0	4	5	1	0.755	1.000	1.000
432	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(2), ILVBL(2), LARS(3), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1), VARS(2), VARS2(2)	11227977	22	18	22	8	0	6	2	8	6	0	0.713	1.000	1.000
433	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(6), ALG11(3), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG5(1), ALG6(2), ALG8(1), B4GALT3(2), DOLPP1(2), DPAGT1(5), DPM1(1), MAN1A1(2), MAN1A2(1), MAN2A1(3), MGAT4A(3), MGAT4B(1), MGAT5(3), MGAT5B(2), RPN1(2), RPN2(1), STT3B(3)	27562098	57	47	56	11	0	12	2	21	22	0	0.250	1.000	1.000
434	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(4), ARHGEF1(2), GNA12(1), GNA13(4), GNB1(2), MYL2(1), MYLK(4), PLCB1(1), PPP1R12B(1), PRKCA(2), ROCK1(4)	13493006	26	26	26	8	1	2	0	16	7	0	0.781	1.000	1.000
435	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), BAAT(1), CEL(1), CYP27A1(1), HADHB(3), SOAT2(2)	15300366	24	23	21	6	2	2	2	10	8	0	0.741	1.000	1.000
436	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACP6(1), ENPP3(1), FLAD1(2), MTMR1(1), MTMR2(1), TYR(5)	9877713	15	15	15	5	0	3	0	9	3	0	0.794	1.000	1.000
437	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(1), CD3G(2), ETV5(1), IL12RB1(2), IL12RB2(2), IL18R1(1), JAK2(5), JUN(2), MAPK14(1), STAT4(1), TYK2(6)	12283508	24	24	23	7	2	0	3	12	7	0	0.830	1.000	1.000
438	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(3), G6PD(2), GPI(3), PFKL(1), PFKM(3), PFKP(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RPE(1), TALDO1(1), TKT(1), TKTL1(1), TKTL2(2)	15635698	27	26	25	8	1	5	4	6	11	0	0.709	1.000	1.000
439	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(2), ARG1(1), ASL(4), CPS1(4), GATM(1), OAT(1), ODC1(2), OTC(1), PYCR1(1), SMS(2)	11356087	19	19	19	6	0	2	4	8	5	0	0.765	1.000	1.000
440	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2), STAT5B(2)	19635714	50	46	45	11	4	10	4	20	12	0	0.397	1.000	1.000
441	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(5), G6PD(2), GCLC(1), GGT1(2), GPX6(1), GSR(1), GSS(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTM1(1), IDH1(2), IDH2(5), OPLAH(2), TXNDC12(1)	14138763	27	23	24	7	0	2	6	8	11	0	0.724	1.000	1.000
442	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(2), CPEB1(3), EGFR(9), ERBB2(4), ERBB4(6), ETS1(1), ETS2(1), ETV6(2), FMN2(5), GRB2(2), KRAS(1), MAPK3(1), NOTCH1(5), NOTCH2(9), NOTCH3(8), NOTCH4(5), PIWIL1(2), PIWIL2(2), PIWIL3(3), PIWIL4(1), RAF1(1), SOS1(5), SOS2(3), SPIRE1(1), SPIRE2(1)	32271932	83	69	80	17	12	7	10	33	19	2	0.221	1.000	1.000
443	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(7), CALM2(1), CAPN2(2), EP300(11), HDAC1(2), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(2), PPP3CC(3), PRKCA(2), SYT1(1)	15555640	39	32	34	10	4	4	4	14	13	0	0.485	1.000	1.000
444	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CD28(1), CSK(3), CTLA4(1), DTYMK(1), EPHB2(2), FBXW7(2), GRAP2(1), GRB2(2), ITK(1), ITPKB(2), LCP2(1), NCK1(1), NFAT5(6), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PLCG1(2), PTPRC(6), RAF1(1), RASGRP1(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(5), SOS2(3), VAV1(3)	36156246	69	57	68	12	6	9	7	27	20	0	0.126	1.000	1.000
445	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(5), ACE2(2), AGT(1), AGTR1(2), ANPEP(5), CMA1(1), CTSA(1), ENPEP(2), LNPEP(2), MAS1(1), MME(5), REN(1), THOP1(1)	13831036	29	26	25	8	1	4	8	7	9	0	0.665	1.000	1.000
446	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM2(1), ELK1(1), FOS(1), GNAI1(1), GNAS(5), GNB1(2), HRAS(1), JUN(2), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), RAF1(1), SYT1(1)	21997311	51	44	48	12	7	6	2	19	17	0	0.465	1.000	1.000
447	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(5), ALAS2(3), BLVRA(1), COX10(2), COX15(1), CP(1), CPOX(5), EPRS(2), FECH(2), FTMT(3), GUSB(5), HCCS(1), HMOX1(2), MMAB(1), PPOX(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), UROD(1)	27766131	64	56	58	14	5	8	8	24	19	0	0.322	1.000	1.000
448	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GHR(1), GRB2(2), HRAS(1), INSR(4), IRS1(4), JAK2(5), MAPK3(1), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), PTPN6(3), RAF1(1), RPS6KA1(7), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2)	21326306	57	50	46	13	5	10	5	18	18	1	0.423	1.000	1.000
449	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT2(3), AKT3(1), BCL10(1), CARD11(8), CD19(1), CD22(4), CD72(1), CHUK(1), CR2(2), FOS(1), GSK3B(3), HRAS(1), IKBKB(1), INPP5D(2), JUN(2), KRAS(1), LILRB3(3), MALT1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIB(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(2), PPP3CA(2), PPP3CC(3), PTPN6(3), RAC3(1), RASGRP3(1), SYK(1), VAV1(3), VAV2(4)	48185133	106	87	95	20	5	19	9	39	34	0	0.104	1.000	1.000
450	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CXCR4(1), FOS(1), JUN(2), MAPK14(1), PLCG1(2), PRKCA(2), PTK2B(3), SYT1(1)	8980806	15	14	14	6	2	4	1	4	4	0	0.819	1.000	1.000
451	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(1), CAD(9), CPS1(4), EPRS(2), GAD2(1), GCLC(1), GLS(3), GLS2(4), GOT1(3), GOT2(2), GPT(2), GPT2(2), GSS(1), NADSYN1(1), QARS(1)	21914311	38	33	34	7	2	4	7	11	13	1	0.356	1.000	1.000
452	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(3), AKT3(1), CD19(1), CSK(3), EPHB2(2), GRB2(2), ITPKB(2), NFAT5(6), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CA(10), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(5), SOS2(3), SYK(1), VAV1(3)	33550726	59	52	56	10	5	14	7	21	12	0	0.0318	1.000	1.000
453	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(2), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2)	6802671	10	10	10	5	2	1	2	4	1	0	0.775	1.000	1.000
454	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(1), ARHGAP5(4), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(1), ARPC2(8), CFL1(1), DIAPH1(3), GSN(2), LIMK1(4), MYL2(1), MYLK(4), OPHN1(2), PIP5K1A(2), PPP1R12B(1), ROCK1(4), SRC(1), TLN1(6), VCL(2)	29634613	57	49	48	9	2	5	2	18	30	0	0.243	1.000	1.000
455	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(1), DAXX(5), EGF(4), EGFR(9), ETS1(1), ETS2(1), FOS(1), HRAS(1), IKBKB(1), JUN(2), MAP2K3(2), MAP2K7(1), MAP3K1(5), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(1), NFKB1(1), PPP2CA(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), RAF1(1), RELA(5), RIPK1(1), SP1(2), TNFRSF1A(1), TRAF2(1)	31927150	72	57	66	15	9	7	2	27	26	1	0.387	1.000	1.000
456	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(2), ARF1(1), EEA1(6), GSK3A(1), GSK3B(3), PFKL(1), PFKM(3), PFKP(2), PLCG1(2), PRKCE(2), PRKCZ(1), RAB5A(1), RPS6KB1(2), VAV2(4)	16531177	32	28	29	8	2	5	4	9	12	0	0.511	1.000	1.000
457	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(2), BID(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), CHUK(1), DFFB(1), FAS(1), HELLS(2), IKBKB(1), IRF5(1), IRF6(5), IRF7(1), JUN(2), LTA(1), MAP3K1(5), MAPK10(1), NFKB1(1), NFKBIB(1), PRF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TNFRSF21(1), TNFSF10(6), TP53(15), TP73(3), TRADD(2), TRAF2(1), TRAF3(1)	36615953	76	56	64	15	2	11	6	23	31	3	0.256	1.000	1.000
458	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10A(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL27(1), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL32(1), RPL34(1), RPL36AL(1), RPL38(1), RPL3L(2), RPL7(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS9(1)	14457472	36	34	36	9	2	3	6	18	7	0	0.494	1.000	1.000
459	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(1), ACADS(3), ACSM1(1), AKR1B10(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(5), GAD2(1), HADH(1), HADHA(2), HMGCS1(1), HMGCS2(1), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), PLA1A(3), RDH11(3)	26710355	46	40	42	9	6	7	6	12	15	0	0.192	1.000	1.000
460	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(6), ACACB(4), FASN(3), OLAH(1), OXSM(1)	10057712	15	15	15	5	2	0	4	6	3	0	0.683	1.000	1.000
461	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA14(3), CA5B(1), CA7(1), CA9(1), CPS1(4), CTH(1), GLS(3), GLS2(4), HAL(1)	12473657	20	19	20	6	1	2	2	14	1	0	0.667	1.000	1.000
462	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(2), ATM(15), BID(1), CASP7(1), CASP9(1), PRKCA(2), PTK2(1), PXN(1), STAT1(3), TLN1(6), TP53(15)	18131537	49	41	47	11	3	7	3	15	19	2	0.407	1.000	1.000
463	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(15), CCNA1(7), CCND2(1), CCNE1(1), CCNE2(2), CCNG2(1), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), CREB3L1(1), CREB3L4(3), E2F1(1), E2F5(1), GBA2(3), MCM2(6), MCM5(2), MCM6(3), MCM7(5), MNAT1(1), MYT1(2), NACA(10), PCNA(2), POLE(4), POLE2(1), PRIM1(2), RB1(2), RPA1(2), RPA2(1), RPA3(1), TFDP2(5), TNXB(5), TP53(15), WEE1(1)	49024551	121	79	105	22	6	11	10	38	54	2	0.178	1.000	1.000
464	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PLCG1(2), PTPN6(3), RAF1(1), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2)	13912285	31	29	29	8	3	4	3	12	9	0	0.640	1.000	1.000
465	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	DOCK1(1), ELK1(1), FOS(1), GAB1(1), GRB2(2), HGF(1), HRAS(1), ITGA1(5), ITGB1(4), JUN(2), MAP4K1(1), MAPK3(1), MET(6), PAK1(2), PIK3CA(10), PIK3R1(2), PTEN(21), PTK2(1), PTK2B(3), PTPN11(1), PXN(1), RAF1(1), RAP1A(1), RASA1(3), SOS1(5), SRC(1), STAT3(3)	29700800	82	64	77	18	5	18	3	26	29	1	0.327	1.000	1.000
466	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(1), AGTR1(2), CMA1(1), COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(7), COL4A6(4), REN(1)	16834151	27	25	27	9	3	10	3	7	4	0	0.534	1.000	1.000
467	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(7), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GALM(2), GAPDH(2), GAPDHS(2), GPI(3), HK1(5), LDHAL6B(1), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKL(1), PFKM(3), PFKP(2), PGAM2(1), PGK1(3), TPI1(1)	37949123	81	64	72	17	6	7	11	23	33	1	0.324	1.000	1.000
468	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR1(1), SNAP23(1), STX10(1), STX11(1), STX16(1), STX19(1), STX2(1), STX4(1), STX7(1), STX8(1), TSNARE1(2), VAMP2(1)	11051827	13	13	13	8	2	2	1	5	3	0	0.926	1.000	1.000
469	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(1), GTF2E1(1), GTF2E2(2), GTF2F2(1), GTF2H1(2), GTF2H2(1), ILK(4), MNAT1(1), POLR1A(4), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLR3B(3), POLR3H(1), POLR3K(1), TAF5(2), TAF6(1), TAF7(1), TBP(1)	23174090	46	41	42	9	1	6	5	13	21	0	0.324	1.000	1.000
470	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), AKR1B10(2), ALDOA(1), ALDOB(3), FPGT(1), FUK(2), GMDS(1), GMPPA(1), GMPPB(1), HK1(5), KHK(3), MPI(1), MTMR1(1), MTMR2(1), PFKFB3(1), PFKL(1), PFKM(3), PFKP(2), PGM2(2), RDH11(3), SORD(10), TPI1(1)	24272749	49	45	42	11	8	3	6	11	21	0	0.493	1.000	1.000
471	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), ARHGDIB(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), DFFB(1), LMNB1(3), PRF1(1)	12493614	20	19	20	7	0	6	2	7	5	0	0.692	1.000	1.000
472	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AGK(5), AKR1B1(3), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), CEL(1), DAK(2), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), GK(1), GK2(1), GLA(1), GLB1(5), GPAM(2), LCT(2), LIPC(1), LIPF(1), LPL(2), PNLIP(4), PNPLA3(2), PPAP2B(1), PPAP2C(2)	38525819	68	55	65	13	6	10	8	22	22	0	0.120	1.000	1.000
473	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(3), AKT3(1), CD19(1), CD22(4), CR2(2), CSK(3), FLOT2(1), GRB2(2), GSK3A(1), GSK3B(3), INPP5D(2), ITPR1(4), ITPR2(9), ITPR3(4), MAP4K1(1), MAPK3(1), NFATC1(2), NFATC2(5), PDK1(1), PIK3CA(10), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP1R13B(3), PPP3CA(2), PPP3CC(3), PTPRC(6), RAF1(1), SHC1(3), SOS1(5), SOS2(3), SYK(1), VAV1(3)	47914536	96	74	87	18	8	19	10	30	29	0	0.0430	1.000	1.000
474	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(4), DIAPH1(3), FYN(2), GSN(2), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), MYL2(1), MYLK(4), PIK3CA(10), PIK3R1(2), PTK2(1), PXN(1), RAF1(1), ROCK1(4), SHC1(3), SRC(1), TLN1(6)	24546785	56	51	52	13	4	11	3	21	17	0	0.346	1.000	1.000
475	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1R(1), IRS1(4), JUN(2), MAPK3(1), PIK3CA(10), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(3), SHC1(3), SOS1(5)	15775979	38	36	35	10	6	12	2	14	4	0	0.309	1.000	1.000
476	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADSL(1), AK2(1), AK5(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(2), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), CANT1(1), ENPP3(1), ENTPD2(1), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HPRT1(1), IMPDH1(1), NPR1(4), NPR2(4), NT5M(2), PAPSS1(2), PAPSS2(2), PDE1A(1), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(1), PDE6B(3), PDE6C(2), PDE8A(2), PDE9A(8), PFAS(2), POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(9), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLRMT(2), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(2), RRM1(2), RRM2(1)	83661134	166	119	155	28	16	20	15	58	57	0	0.0229	1.000	1.000
477	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(1), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SMPD2(2), SPTLC1(1)	15163689	24	22	24	8	1	5	4	8	6	0	0.678	1.000	1.000
478	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(1), CAD(9), CPS1(4), EPRS(2), GAD2(1), GCLC(1), GFPT2(1), GLS(3), GLS2(4), GOT1(3), GOT2(2), GPT(2), GPT2(2), GSR(1), GSS(1), NADSYN1(1), NAGK(2), QARS(1)	26048357	42	36	38	8	3	4	9	12	13	1	0.301	1.000	1.000
479	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(1), CAMK1G(3), ELK1(1), FPR1(2), GNA15(1), GNB1(2), HRAS(1), MAP2K3(2), MAP3K1(5), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), PAK1(2), PIK3C2G(2), PLCB1(1), PPP3CA(2), PPP3CC(3), RAF1(1), RELA(5), SYT1(1)	25044200	56	45	50	13	5	7	3	17	23	1	0.506	1.000	1.000
480	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT2(3), AKT3(1), ANKRD6(2), APC(7), AXIN1(2), AXIN2(1), CSNK1A1(2), CTNNB1(1), DACT1(1), DVL1(1), FSTL1(2), GSK3A(1), GSK3B(3), LRP1(11), MVP(4), NKD1(2), NKD2(1), PTPRA(3), SENP2(1), WIF1(4)	26105870	54	46	50	12	3	10	7	16	18	0	0.223	1.000	1.000
481	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(1), ARSE(1), CYP11B2(2), HSD17B2(1), HSD17B8(1), HSD3B1(1), SULT2A1(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2)	17731963	23	21	23	6	1	3	3	7	9	0	0.531	1.000	1.000
482	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(4), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(1), AKT2(3), AKT3(1), CAMKK1(2), CAMKK2(2), CHUK(1), CPT1A(1), CPT1C(4), CPT2(1), G6PC(3), IKBKB(1), IRS1(4), IRS4(1), JAK1(4), JAK2(5), JAK3(3), LEP(1), LEPR(1), MAPK10(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIB(1), NPY(1), PCK1(4), PCK2(1), POMC(1), PPARGC1A(3), PRKAA2(4), PRKAB1(1), PRKAG1(4), PRKAG2(4), PRKCQ(4), PTPN11(1), RELA(5), RXRB(4), RXRG(2), SLC2A1(1), SOCS3(1), STAT3(3), TNFRSF1A(1), TRADD(2), TRAF2(1), TYK2(6)	52609862	124	93	105	26	5	16	18	42	42	1	0.278	1.000	1.000
483	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), ASRGL1(4), CA14(3), CA5B(1), CA7(1), CA9(1), CPS1(4), CTH(1), GLS(3), GLS2(4), HAL(1)	13903166	24	23	21	7	1	2	2	14	5	0	0.681	1.000	1.000
484	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BID(1), BIRC2(2), BIRC3(2), CASP10(2), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), DFFB(1), GAS2(2), NFKB1(1), RELA(5), RIPK1(1), SPTAN1(6), TNFSF10(6), TRADD(2), TRAF2(1)	21839088	39	32	33	8	0	5	4	13	16	1	0.387	1.000	1.000
485	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(1), CREBBP(5), EHHADH(5), EP300(11), FABP1(3), JUN(2), LPL(2), MAPK3(1), ME1(1), NCOA1(2), NCOR1(4), NCOR2(6), NR1H3(2), NRIP1(4), PIK3CA(10), PIK3R1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PTGS2(4), RB1(2), RELA(5), SP1(2), STAT5A(2), STAT5B(2)	40707164	88	64	76	19	4	14	9	30	30	1	0.199	1.000	1.000
486	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(6), ACACB(4), ACSS1(2), ACSS2(7), AKR1B1(3), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), ME1(1), ME2(2), ME3(2), PC(3), PCK1(4), PCK2(1), PDHA1(1), PDHA2(2), PDHB(1)	30516346	60	50	56	13	2	8	11	12	26	1	0.340	1.000	1.000
487	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), AKT2(3), AKT3(1), CASP8(1), CCL3(1), CD86(1), CHUK(1), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IKBKB(1), IKBKE(1), IL1B(1), IRAK1(3), IRAK4(1), IRF5(1), IRF7(1), JUN(2), LBP(1), LY96(1), MAP2K3(2), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), NFKB1(1), NFKB2(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RELA(5), RIPK1(1), SPP1(3), STAT1(3), TBK1(2), TICAM1(3), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR6(1), TLR7(3), TLR8(5), TLR9(1), TRAF3(1), TRAF6(2)	57605629	112	93	104	20	8	20	12	52	19	1	0.0361	1.000	1.000
488	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(2), ADCY8(8), ATF4(2), BRAF(2), CACNA1C(9), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(5), EP300(11), GRIA1(6), GRIA2(3), GRIN1(2), GRIN2A(6), GRIN2B(6), GRM1(4), GRM5(7), HRAS(1), ITPR1(4), ITPR2(9), ITPR3(4), KRAS(1), MAPK3(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PPP1R12A(2), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), RAF1(1), RAP1A(1), RAPGEF3(1), RPS6KA1(7), RPS6KA6(1)	66267243	135	97	125	26	15	14	12	51	41	2	0.0713	1.000	1.000
489	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX5(2), CYP1A2(3), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2J2(3), CYP3A7(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), RDH11(3)	15699422	22	22	22	8	3	2	3	9	5	0	0.688	1.000	1.000
490	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(1), CABIN1(7), CALM2(1), CAMK2B(1), CAMK4(1), CD3E(1), CD3G(2), CDKN1A(1), CNR1(1), CREBBP(5), CSNK2B(1), CTLA4(1), EGR2(1), EGR3(1), EP300(11), FOS(1), GATA3(2), GATA4(2), GSK3A(1), GSK3B(3), HRAS(1), ICOS(2), IFNA1(1), IFNB1(2), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(1), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2D(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB2(1), NFKBIB(1), NPPB(1), NUP214(3), OPRD1(2), P2RX7(1), PAK1(2), PPP3CC(3), PTPRC(6), RELA(5), SLA(1), SP1(2), SP3(2), TRAF2(1), TRPV6(4), VAV1(3), VAV2(4), XPO5(3)	58343361	129	92	118	26	12	14	16	44	42	1	0.120	1.000	1.000
491	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(2), DLAT(2), DLD(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), OGDH(3), PC(3), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(2), PDK3(2), PDP2(2), SDHA(1), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(5), SUCLG2(2)	18653873	44	36	41	12	1	7	6	17	13	0	0.562	1.000	1.000
492	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFB(1), JUN(2), LMNB1(3), MADD(5), MAP3K1(5), MAP3K7(1), PAK1(2), PAK2(2), PRKDC(10), RB1(2), RIPK1(1), SPTAN1(6), TNFRSF1A(1), TRADD(2), TRAF2(1)	25861196	48	42	48	10	1	7	7	15	18	0	0.221	1.000	1.000
493	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP2K7(1), MAP3K1(5), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PAK2(2), PIK3CA(10), PIK3R1(2), PLA2G4A(1), PLCG1(2), PPP3CA(2), PPP3CC(3), RAF1(1), SHC1(3), SOS1(5), SYK(1), SYT1(1), VAV1(3)	27670642	66	58	60	16	6	12	5	22	21	0	0.377	1.000	1.000
494	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(5), CTBP1(1), CTBP2(1), DLL1(1), DLL4(2), DTX1(4), DTX3(1), DTX3L(1), DTX4(4), DVL1(1), DVL2(1), EP300(11), HDAC1(2), JAG1(5), JAG2(2), MAML1(5), MAML2(2), MAML3(4), NCOR2(6), NCSTN(1), NOTCH1(5), NOTCH2(9), NOTCH3(8), NOTCH4(5), NUMB(2), NUMBL(1), PSEN2(2), PSENEN(1), PTCRA(1), RBPJ(3), RBPJL(7), SNW1(3)	41783564	107	78	97	25	11	8	14	30	42	2	0.411	1.000	1.000
495	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(6), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), LDHC(3), MDH1(1), ME1(1), ME2(2), ME3(2), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1)	24117765	47	42	44	11	2	6	7	11	21	0	0.437	1.000	1.000
496	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(2), BIRC3(2), CASP8(1), CFLAR(1), JUN(2), MAP3K3(2), MAP3K7(1), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	17018286	23	22	23	7	0	5	5	9	4	0	0.512	1.000	1.000
497	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(1), CBL(2), CFLAR(1), E2F1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), IRS1(4), JAK1(4), JAK3(3), MAPK3(1), PIK3CA(10), PIK3R1(2), PTPN6(3), RAF1(1), RPS6KB1(2), SHC1(3), SOCS3(1), SOS1(5), STAT5A(2), STAT5B(2), SYK(1)	22934644	57	53	53	15	6	13	7	15	16	0	0.324	1.000	1.000
498	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSE(1), CYP11B2(2), CYP19A1(2), HSD17B1(1), HSD17B2(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SULT2A1(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3)	32479861	50	45	50	11	4	7	7	19	13	0	0.324	1.000	1.000
499	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPS(1), CHPT1(2), ENPP2(1), PAFAH1B1(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(5), PPAP2B(1), PPAP2C(2)	15330061	21	20	19	9	3	2	2	9	5	0	0.901	1.000	1.000
500	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(3), AKT3(1), ASAH1(1), BRAF(2), DRD2(1), EGFR(9), EPHB2(2), GRB2(2), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), KCNJ3(3), PIK3CB(3), PITX2(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), RAF1(1), SHC1(3), SOS1(5), SOS2(3), SRC(1), STAT3(3)	38247862	74	56	72	16	8	12	12	26	15	1	0.120	1.000	1.000
501	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(5), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), ATP7A(3), ATP7B(5), COX10(2), NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB6(1), NDUFS1(5), NDUFS2(1), NDUFV1(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SHMT1(2), UQCRC1(1), UQCRFS1(1)	25317507	51	43	50	13	3	9	8	20	11	0	0.357	1.000	1.000
502	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(7), COL4A6(4), F11(1), F12(3), F2(2), F5(7), F8(5), F9(2), FGA(2), FGB(1), FGG(5), KLKB1(2), PROC(3), PROS1(4), SERPING1(2)	29418959	59	53	57	16	6	11	3	21	17	1	0.423	1.000	1.000
503	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CAD(9), CANT1(1), DCTD(1), DPYD(4), DPYS(2), DTYMK(1), ENTPD5(1), NME7(1), NT5C1B(1), NT5C2(1), NT5M(2), POLA1(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLR1A(4), POLR1B(2), POLR1C(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(2), RFC5(1), RRM1(2), RRM2(1), TK1(1), TK2(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(1), UPB1(1), UPP2(2), UPRT(2)	53777536	91	70	83	17	3	16	11	28	32	1	0.0640	1.000	1.000
504	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), CEL(1), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), GK(1), GLA(1), GLB1(5), LCT(2), LIPC(1), LIPF(1), LPL(2), PNLIP(4), PPAP2B(1), PPAP2C(2)	31560764	55	44	52	13	6	9	5	16	19	0	0.314	1.000	1.000
505	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(4), ASH2L(2), CTCFL(2), DOT1L(2), EHMT1(3), EHMT2(3), EZH1(1), EZH2(4), FBXO11(2), HCFC1(6), HSF4(3), JMJD4(1), JMJD6(4), KDM6A(3), MEN1(1), NSD1(8), OGT(4), PAXIP1(1), PRDM2(1), PRDM6(1), PRDM7(2), PRDM9(3), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), RBBP5(3), SATB1(2), SETD1A(4), SETD2(52), SETD7(1), SETDB1(4), SETMAR(2), SMYD3(2), SUV39H2(4), SUV420H1(2), SUZ12(5), WHSC1(4), WHSC1L1(5)	79066801	157	116	153	29	9	19	14	45	67	3	0.0542	1.000	1.000
506	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GAPDH(2), GAPDHS(2), GOT1(3), GOT2(2), GPI(3), HK1(5), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PFKL(1), PFKM(3), PFKP(2), PGAM2(1), PGK1(3), TNFAIP1(1), TPI1(1)	27486661	64	52	60	17	4	6	9	15	30	0	0.584	1.000	1.000
507	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GAPDH(2), GPI(3), HK1(5), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKM(3), PFKP(2), PGK1(3), TPI1(1)	31870819	65	52	57	16	6	4	7	20	28	0	0.587	1.000	1.000
508	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GAPDH(2), GPI(3), HK1(5), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKM(3), PFKP(2), PGK1(3), TPI1(1)	31870819	65	52	57	16	6	4	7	20	28	0	0.587	1.000	1.000
509	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(1), CP(1), CPOX(5), EPRS(2), FECH(2), GUSB(5), HCCS(1), HMOX1(2), PPOX(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2), UROD(1)	18053735	36	33	32	10	4	4	4	10	14	0	0.676	1.000	1.000
510	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(4), ABL2(4), AKT1(1), AKT2(3), AKT3(1), BRAF(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(2), CBLC(1), CDKN1A(1), EGF(4), EGFR(9), ELK1(1), ERBB2(4), ERBB3(4), ERBB4(6), GAB1(1), GRB2(2), GSK3B(3), HRAS(1), JUN(2), KRAS(1), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK9(2), NCK1(1), NRG1(1), NRG2(2), NRG3(2), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCG(2), PTK2(1), RAF1(1), RPS6KB1(2), RPS6KB2(2), SHC1(3), SHC2(1), SOS1(5), SOS2(3), SRC(1), STAT5A(2), STAT5B(2)	66806047	141	102	130	29	11	25	17	49	38	1	0.0934	1.000	1.000
511	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ALG6(2), CCKBR(1), CELSR1(11), CELSR2(6), CELSR3(5), CHRM2(3), CHRM3(2), CIDEB(1), EMR2(2), EMR3(9), FSHR(2), GPR116(4), GPR133(3), GPR143(1), GPR17(2), GPR61(1), GPR84(3), GRM1(4), GRPR(1), HRH4(1), LGR6(2), LPHN2(3), LPHN3(8), NTSR1(1), P2RY11(1), P2RY13(1), PTGFR(3), SMO(3), TSHR(2)	41481571	88	67	84	21	13	14	7	27	27	0	0.187	1.000	1.000
512	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(7), COL4A6(4), SLC23A1(4), SLC23A2(1), SLC2A1(1), SLC2A3(2)	16805555	28	27	28	10	3	10	1	9	5	0	0.704	1.000	1.000
513	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(7), ASAH1(1), DLG4(1), EPHB2(2), GNAI1(1), ITPR1(4), ITPR2(9), ITPR3(4), KCNJ3(3), PITX2(2), RHO(1), RYR1(13)	29642229	49	44	49	12	9	8	7	17	8	0	0.172	1.000	1.000
514	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMP7(3), BMP8A(4), BMP8B(1), BTRC(2), CSNK1A1(2), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(4), GLI2(4), GLI3(5), GSK3B(3), HHIP(3), LRP2(17), PRKACA(1), PRKACB(2), PRKACG(2), PTCH1(9), PTCH2(2), SHH(1), SMO(3), STK36(2), SUFU(1), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1)	37361099	88	72	78	22	10	9	6	37	26	0	0.508	1.000	1.000
515	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(1), ACVR1B(3), ACVR1C(3), ACVR2A(1), ACVR2B(1), AMHR2(7), BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMP7(3), BMP8A(4), BMP8B(1), BMPR1B(1), BMPR2(5), CHRD(3), CREBBP(5), CUL1(3), DCN(3), E2F5(1), EP300(11), GDF5(1), GDF6(1), INHBA(2), INHBB(1), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(3), MAPK3(1), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), RBL2(2), ROCK1(4), ROCK2(2), RPS6KB1(2), RPS6KB2(2), SMAD2(2), SMAD3(1), SMAD4(1), SMAD5(1), SMAD9(1), SMURF1(1), SMURF2(2), SP1(2), TGFB2(1), TGFBR2(1), THBS1(11), THBS2(1), THBS3(4), THBS4(1), ZFYVE16(1), ZFYVE9(5)	63765341	134	101	121	27	9	9	15	49	52	0	0.230	1.000	1.000
516	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(1), ALDH18A1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOC2(3), AOC3(1), ARG1(1), ASL(4), ASS1(2), CPS1(4), GATM(1), MAOA(1), ODC1(2), OTC(1), SAT1(1), SMS(2)	19122684	33	33	31	10	0	5	6	10	12	0	0.725	1.000	1.000
517	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L4(3), CREBBP(5), CTNNB1(1), DCT(4), DVL1(1), DVL2(1), EDNRB(3), EP300(11), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD4(3), FZD5(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(5), GSK3B(3), HRAS(1), KITLG(2), KRAS(1), LEF1(1), MAPK3(1), MC1R(2), MITF(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), POMC(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), RAF1(1), TCF7L2(1), TYR(5), TYRP1(1), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1)	68695131	135	100	129	28	14	13	16	59	33	0	0.0728	1.000	1.000
518	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOC2(3), AOC3(1), AOX1(7), CAT(2), CYP1A1(1), CYP1A2(3), CYP1B1(1), DDC(2), ECHS1(2), EHHADH(5), GCDH(3), HAAO(1), HADH(1), HADHA(2), LCMT1(1), LCMT2(3), MAOA(1), NFX1(1), OGDH(3), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), TPH1(1), TPH2(1), WARS(1), WARS2(1)	39559123	65	56	60	15	4	12	10	20	19	0	0.327	1.000	1.000
519	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(6), DARS(1), EPRS(2), HARS(1), IARS(4), LARS(3), LARS2(2), MARS(2), MARS2(3), QARS(1), RARS(2), SARS(2), TARS(5), WARS(1), WARS2(1), YARS(1)	21368148	39	32	36	10	0	4	6	17	12	0	0.598	1.000	1.000
520	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(3), AKT3(1), ARHGEF11(5), CDC42(1), DLG4(1), GNA13(4), LPA(6), MAP3K1(5), MAP3K5(5), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(3), PLD1(2), PLD2(5), PLD3(3), PTK2(1), RDX(1), ROCK1(4), ROCK2(2), TBXA2R(2)	31808522	63	54	59	15	4	7	7	26	19	0	0.447	1.000	1.000
521	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA2(3), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5E(1), INPPL1(2), IPMK(1), ITPK1(1), ITPKB(2), MINPP1(1), MIOX(2), OCRL(2), PI4KA(9), PI4KB(3), PIK3C3(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PTEN(21), PTPMT1(1), SYNJ1(5), SYNJ2(5)	48426727	119	92	112	29	8	17	8	38	46	2	0.467	1.000	1.000
522	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(3), BTG1(2), CLOCK(1), EIF4G2(3), ETV6(2), HERPUD1(1), HSPA8(7), IDI1(1), KLF9(2), MYF6(2), NCKAP1(1), NCOA4(5), NR1D2(1), PER1(4), PER2(4), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(1), TOB1(2), UGP2(1), ZFR(4)	23817899	51	48	50	14	2	7	10	17	15	0	0.490	1.000	1.000
523	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(11), B3GALT4(1), CDR1(2), DGKI(1), IL6ST(3), PIGK(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL23(1), RPL27(1), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL32(1), RPL34(1), RPL38(1), RPL3L(2), RPL4(2), RPL5(3), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(1), RPS19(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(7), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), RPS9(1), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(3)	33964219	81	71	77	19	4	7	13	31	25	1	0.491	1.000	1.000
524	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(2), G6PC(3), GAA(1), GALK1(1), GALK2(1), GALT(3), GANC(2), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(2), MGAM(5), PFKL(1), PFKM(3), PFKP(2), RDH11(3), UGP2(1)	24901001	45	40	44	13	4	6	6	13	16	0	0.597	1.000	1.000
525	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), ALAS1(5), ALAS2(3), AOC2(3), AOC3(1), BHMT(2), CHDH(2), CHKB(2), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(1), GLDC(3), MAOA(1), PISD(1), PLCB2(2), PLCG1(2), PLCG2(2), SARDH(3), SARS(2), SHMT1(2), SHMT2(3), TARS(5)	27427385	54	50	50	15	5	7	9	14	19	0	0.499	1.000	1.000
526	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG1(1), ASL(4), ASS1(2), CPS1(4), DAO(1), EPRS(2), GATM(1), GOT1(3), GOT2(2), LAP3(2), NOS1(9), NOS3(2), OAT(1), OTC(1), P4HA1(3), P4HA2(1), PARS2(3), PRODH(1), PYCR1(1), PYCR2(1), RARS(2)	23285057	48	43	48	14	3	5	11	17	12	0	0.609	1.000	1.000
527	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AKR1C1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), CYP1A1(1), CYP1A2(3), CYP1B1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP3A7(1), DHDH(2), EPHX1(4), GSTA3(1), GSTA4(1), GSTA5(1), GSTM1(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3)	38058446	67	53	63	17	7	7	9	24	20	0	0.481	1.000	1.000
528	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(4), ANGPTL4(2), APOA5(2), AQP7(3), CPT1A(1), CPT1C(4), CPT2(1), CYP27A1(1), CYP4A11(4), CYP8B1(3), DBI(1), EHHADH(5), FABP1(3), FABP3(1), FADS2(2), GK(1), GK2(1), HMGCS2(1), ILK(4), LPL(2), ME1(1), NR1H3(2), PCK1(4), PCK2(1), PLTP(2), PPARD(1), PPARG(2), RXRB(4), RXRG(2), SCP2(2), SLC27A1(2), SLC27A2(1), SLC27A5(2), SLC27A6(6), SORBS1(1), UBC(3), UCP1(1)	42196205	105	79	88	28	6	11	14	41	33	0	0.583	1.000	1.000
529	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), CDK2(2), CDT1(1), DIAPH2(2), MCM10(2), MCM2(6), MCM5(2), MCM6(3), MCM7(5), NACA(10), PCNA(2), POLD1(6), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(4), RFC2(1), RFC4(1), RFC5(1), RPA1(2), RPA2(1), RPA3(1), RPA4(1), RPS27A(1), UBB(1), UBC(3)	33302474	68	55	60	18	5	7	6	24	26	0	0.689	1.000	1.000
530	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT3(2), B4GALT4(2), B4GALT6(1), FUT6(2), GBGT1(2), GCNT2(2), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(2), PIGO(4), PIGP(1), PIGQ(3), PIGT(6), PIGU(1), PIGV(1), PIGZ(3), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	30918368	65	54	60	19	5	9	8	18	24	1	0.702	1.000	1.000
531	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), ACTN2(3), BCAR1(3), CAPN1(1), CSK(3), FYN(2), GRB2(2), HRAS(1), ITGA1(5), ITGB1(4), JUN(2), MAPK3(1), PPP1R12B(1), PTK2(1), PXN(1), RAF1(1), RAP1A(1), ROCK1(4), SHC1(3), SOS1(5), SRC(1), TLN1(6), VCL(2), ZYX(1)	30457734	55	46	54	15	4	8	2	26	15	0	0.633	1.000	1.000
532	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSE(1), ASAH1(1), B4GALT6(1), CERK(5), DEGS1(2), ENPP7(2), GAL3ST1(2), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SGPP1(2), SMPD2(2), SPHK2(1), SPTLC1(1), UGT8(1)	22215704	37	33	34	12	4	7	5	10	11	0	0.685	1.000	1.000
533	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(2), AKT1(1), AKT2(3), AKT3(1), ARHGAP5(4), BCAR1(3), BIRC2(2), BIRC3(2), BRAF(2), CAPN2(2), CAV2(1), CCND2(1), CDC42(1), CHAD(2), COL11A1(8), COL11A2(4), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(4), COL5A2(5), COL5A3(10), COL6A1(1), COL6A2(6), COL6A3(12), COL6A6(13), CTNNB1(1), DIAPH1(3), DOCK1(1), EGF(4), EGFR(9), ELK1(1), ERBB2(4), FARP2(2), FIGF(1), FLNA(4), FLNB(4), FLNC(5), FLT1(7), FN1(4), FYN(2), GRB2(2), GSK3B(3), HGF(1), HRAS(1), IBSP(1), IGF1R(1), ILK(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAV(1), ITGB1(4), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), JUN(2), KDR(5), LAMA1(9), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(5), LAMC2(6), LAMC3(5), MAPK10(1), MAPK3(1), MAPK9(2), MET(6), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PARVB(1), PARVG(1), PDGFC(1), PDGFD(2), PDGFRA(5), PDGFRB(1), PGF(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP5K1C(1), PPP1R12A(2), PRKCA(2), PRKCG(2), PTEN(21), PTK2(1), PXN(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF1(3), RELN(5), ROCK1(4), ROCK2(2), SHC1(3), SHC2(1), SOS1(5), SOS2(3), SPP1(3), SRC(1), THBS1(11), THBS2(1), THBS3(4), THBS4(1), TLN1(6), TLN2(8), TNC(8), TNN(2), TNR(8), TNXB(5), VAV1(3), VAV2(4), VCL(2), VEGFC(2), VTN(1), VWF(11), ZYX(1)	239556698	515	256	493	140	50	74	52	172	164	3	0.299	1.000	1.000
534	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY7(1), ADCY8(8), ADCY9(4), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(6), ATP2A2(6), ATP2A3(4), ATP2B1(1), ATP2B3(1), ATP2B4(3), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(5), CACNA1B(4), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(7), CACNA1H(3), CACNA1I(3), CACNA1S(8), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKAR(2), CCKBR(1), CD38(1), CHRM2(3), CHRM3(2), CHRM5(2), CHRNA7(1), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(9), ERBB2(4), ERBB3(4), ERBB4(6), GNA15(1), GNAS(5), GRIN1(2), GRIN2A(6), GRM1(4), GRM5(7), GRPR(1), HRH2(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), MYLK(4), MYLK2(1), NOS1(9), NOS3(2), NTSR1(1), P2RX1(2), P2RX2(3), P2RX3(2), P2RX7(1), PDE1A(1), PDE1B(5), PDE1C(1), PDGFRA(5), PDGFRB(1), PHKA1(5), PHKA2(3), PHKB(2), PHKG1(2), PHKG2(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PPID(1), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), PTAFR(1), PTGER3(5), PTGFR(3), PTK2B(3), RYR1(13), RYR2(11), RYR3(13), SLC25A4(2), SLC25A6(1), SLC8A1(1), SLC8A2(2), SLC8A3(3), SPHK2(1), TACR1(1), TACR3(2), TBXA2R(2), TRHR(2), TRPC1(2), VDAC3(1)	176508822	366	224	349	95	53	47	29	136	101	0	0.113	1.000	1.000
535	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(3), ACVR1C(3), AKT1(1), AKT2(3), AKT3(1), ARRB2(1), ATF2(1), ATF4(2), BRAF(2), CACNA1A(5), CACNA1B(4), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(7), CACNA1H(3), CACNA1I(3), CACNA1S(8), CACNA2D1(3), CACNA2D4(3), CACNB1(1), CACNB2(1), CACNB4(1), CACNG3(2), CACNG5(1), CACNG6(1), CACNG7(1), CDC25B(1), CDC42(1), CHUK(1), DAXX(5), DUSP10(1), DUSP3(2), DUSP4(1), DUSP5(1), DUSP8(1), DUSP9(1), ECSIT(4), EGF(4), EGFR(9), ELK1(1), ELK4(2), FAS(1), FGF10(1), FGF11(1), FGF13(1), FGF14(1), FGF19(1), FGF20(1), FGF3(1), FGF6(2), FGF7(2), FGFR1(5), FGFR2(4), FGFR3(1), FGFR4(3), FLNA(4), FLNB(4), FLNC(5), FOS(1), GNA12(1), GRB2(2), HRAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1R2(4), JUN(2), KRAS(1), MAP2K3(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP4K1(1), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK2(1), MAPT(3), MAX(5), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), NF1(9), NFATC2(5), NFATC4(3), NFKB1(1), NFKB2(1), NTRK1(5), NTRK2(1), PAK1(2), PAK2(2), PDGFRA(5), PDGFRB(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PPM1B(2), PPP3CA(2), PPP3CC(3), PPP5C(2), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), PTPN5(3), PTPN7(1), PTPRR(3), RAC3(1), RAF1(1), RAP1A(1), RAPGEF2(7), RASA1(3), RASA2(1), RASGRF1(3), RASGRF2(3), RASGRP1(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA1(7), RPS6KA4(1), RPS6KA5(1), RPS6KA6(1), RRAS2(8), SOS1(5), SOS2(3), TAOK2(2), TAOK3(1), TGFB2(1), TGFBR2(1), TNFRSF1A(1), TP53(15), TRAF2(1), TRAF6(2), ZAK(3)	187165167	385	221	364	83	38	55	32	138	118	4	0.0228	1.000	1.000
536	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ABI2(2), ACTN1(1), ACTN2(3), ACTN4(2), APC(7), ARHGEF1(2), ARHGEF12(2), ARHGEF6(2), ARHGEF7(4), ARPC2(8), ARPC5L(1), BCAR1(3), BDKRB1(1), BDKRB2(1), BRAF(2), CDC42(1), CFL1(1), CHRM2(3), CHRM3(2), CHRM5(2), CSK(3), CYFIP1(5), CYFIP2(5), DIAPH1(3), DIAPH2(2), DIAPH3(4), DOCK1(1), EGF(4), EGFR(9), EZR(1), F2(2), FGD1(2), FGF10(1), FGF11(1), FGF13(1), FGF14(1), FGF19(1), FGF20(1), FGF3(1), FGF6(2), FGF7(2), FGFR1(5), FGFR2(4), FGFR3(1), FGFR4(3), FN1(4), GIT1(1), GNA12(1), GNA13(4), GSN(2), HRAS(1), IQGAP1(3), IQGAP2(3), IQGAP3(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAD(9), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(3), ITGB1(4), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), KRAS(1), LIMK1(4), LIMK2(2), MAPK3(1), MOS(1), MRAS(1), MSN(2), MYH10(2), MYH14(4), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), NCKAP1(1), NCKAP1L(3), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDGFRA(5), PDGFRB(1), PFN4(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(1), PPP1R12A(2), PPP1R12B(1), PTK2(1), PXN(1), RAC3(1), RAF1(1), RDX(1), ROCK1(4), ROCK2(2), RRAS2(8), SCIN(1), SLC9A1(2), SOS1(5), SOS2(3), SSH1(2), SSH2(8), SSH3(2), TIAM1(6), TIAM2(1), VAV1(3), VAV2(4), VCL(2), WASF2(2), WASL(6)	181384471	365	209	334	87	24	43	42	131	124	1	0.203	1.000	1.000
537	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), ACTG1(3), CHAD(2), COL11A1(8), COL11A2(4), COL17A1(3), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(4), COL5A2(5), COL5A3(10), COL6A1(1), COL6A2(6), COL6A3(12), COL6A6(13), DSC2(2), DSG1(3), DSG2(2), DSG3(2), DSG4(2), FN1(4), GJA10(2), GJA3(1), GJA5(5), GJA8(1), GJA9(1), GJB1(1), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(1), IBSP(1), ITGA6(4), ITGB4(2), KRT1(1), KRT10(1), KRT12(2), KRT13(3), KRT15(1), KRT16(1), KRT17(2), KRT19(1), KRT2(2), KRT23(2), KRT24(1), KRT25(1), KRT27(2), KRT28(2), KRT3(1), KRT31(1), KRT33B(2), KRT36(2), KRT39(1), KRT4(4), KRT5(2), KRT6A(1), KRT6B(2), KRT6C(1), KRT7(1), KRT71(2), KRT72(2), KRT73(2), KRT74(2), KRT75(3), KRT76(1), KRT77(1), KRT78(3), KRT79(4), KRT82(2), KRT83(1), KRT84(2), KRT85(4), KRT86(1), LAMA1(9), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(5), LAMC2(6), LAMC3(5), LMNB1(3), NES(6), PRPH(1), RELN(5), SPP1(3), THBS1(11), THBS2(1), THBS3(4), THBS4(1), TNC(8), TNN(2), TNR(8), TNXB(5), VIM(1), VTN(1), VWF(11)	157743068	342	203	331	108	38	50	33	104	116	1	0.734	1.000	1.000
538	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(2), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRA2B(1), ADRB2(2), AGTR1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), C5AR1(2), CALCR(2), CALCRL(1), CCKAR(2), CCKBR(1), CGA(1), CHRM2(3), CHRM3(2), CHRM5(2), CNR1(1), CNR2(2), CRHR1(1), CRHR2(2), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(3), F2(2), F2RL1(1), F2RL2(1), FPR1(2), FSHR(2), GABBR1(3), GABRA1(2), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRB1(2), GABRB3(1), GABRE(3), GABRG1(2), GABRG2(3), GABRQ(7), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(1), GLP1R(1), GLP2R(2), GLRA1(2), GLRA2(1), GLRB(1), GPR156(1), GPR35(2), GPR50(1), GPR63(1), GPR83(1), GRIA1(6), GRIA2(3), GRIA3(2), GRIA4(3), GRID1(3), GRID2(6), GRIK1(2), GRIK2(4), GRIK3(4), GRIK5(4), GRIN1(2), GRIN2A(6), GRIN2B(6), GRIN3B(2), GRM1(4), GRM2(2), GRM3(3), GRM4(3), GRM5(7), GRM6(2), GRM7(4), GRM8(2), GRPR(1), HRH2(1), HRH4(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), LEP(1), LEPR(1), MAS1(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR2(2), MTNR1B(1), NMUR2(4), NPBWR1(1), NPBWR2(1), NPFFR2(2), NTSR1(1), OPRD1(2), OPRL1(1), OPRM1(3), P2RX1(2), P2RX2(3), P2RX3(2), P2RX7(1), P2RY1(1), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY4(1), P2RY8(2), PARD3(5), PRLR(2), PRSS3(2), PTAFR(1), PTGER2(1), PTGER3(5), PTGER4(1), PTGFR(3), PTGIR(1), RXFP1(1), RXFP2(1), SCTR(1), SSTR1(1), SSTR3(1), SSTR4(1), TAAR2(1), TACR1(1), TACR3(2), TBXA2R(2), THRA(1), TRHR(2), TRPV1(1), TSHR(2), VIPR1(1)	140192782	288	185	275	84	39	37	27	108	77	0	0.430	1.000	1.000
539	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(5), CD44(2), CHAD(2), COL11A1(8), COL11A2(4), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(4), COL5A2(5), COL5A3(10), COL6A1(1), COL6A2(6), COL6A3(12), COL6A6(13), FN1(4), FNDC1(1), FNDC3A(2), FNDC5(1), HMMR(1), HSPG2(9), IBSP(1), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAV(1), ITGB1(4), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), LAMA1(9), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(5), LAMC2(6), LAMC3(5), RELN(5), SDC3(1), SPP1(3), SV2A(1), SV2B(1), SV2C(1), THBS1(11), THBS2(1), THBS3(4), THBS4(1), TNC(8), TNN(2), TNR(8), TNXB(5), VTN(1), VWF(11)	142965294	292	185	282	90	30	43	30	87	101	1	0.704	1.000	1.000
540	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(1), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(2), AKT1(1), AKT2(3), AKT3(1), AMOTL1(1), ASH1L(4), CASK(1), CDC42(1), CDK4(6), CGN(1), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(1), CLDN4(2), CLDN6(1), CLDN7(1), CSNK2A2(1), CSNK2B(1), CTNNA1(4), CTNNA2(4), CTNNA3(2), CTNNB1(1), EPB41(2), EPB41L1(1), EPB41L2(1), EPB41L3(4), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), HRAS(1), IGSF5(4), INADL(4), JAM3(1), KRAS(1), LLGL1(5), LLGL2(1), MAGI1(3), MAGI2(4), MAGI3(4), MLLT4(8), MPDZ(4), MPP5(1), MRAS(1), MYH1(4), MYH10(2), MYH11(8), MYH13(3), MYH14(4), MYH15(3), MYH2(9), MYH3(5), MYH4(10), MYH6(4), MYH7(8), MYH7B(4), MYH8(5), MYL2(1), MYL7(1), MYL9(1), OCLN(2), PARD3(5), PARD6B(4), PPM1J(3), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(1), PTEN(21), RRAS2(8), SPTAN1(6), SRC(1), TJAP1(1), TJP1(2), TJP2(2), TJP3(1), YES1(1), ZAK(3)	127258964	274	167	253	73	25	31	17	84	115	2	0.561	1.000	1.000
541	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ADRA1A(4), ADRB2(2), ANXA6(2), ARRB2(1), ATP1A4(4), ATP2A2(6), ATP2A3(4), ATP2B1(1), ATP2B3(1), CACNA1A(5), CACNA1B(4), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1S(8), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(4), CASQ2(2), CHRM2(3), CHRM3(2), CHRM5(2), GJA5(5), GJB1(1), GJB3(1), GJB6(2), GNAI2(1), GNAO1(1), GNAZ(1), GNB1(2), GNB3(2), GNB5(2), GNG3(1), GRK4(1), GRK5(1), GRK6(5), ITPR1(4), ITPR2(9), ITPR3(4), KCNB1(1), KCNJ3(3), MYCBP(1), NME7(1), PKIA(1), PLCB3(2), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RGS11(1), RGS17(2), RGS18(2), RGS2(2), RGS3(3), RGS6(2), RGS9(4), RYR1(13), RYR2(11), RYR3(13), SLC8A1(1), SLC8A3(3), USP5(2), YWHAB(1)	124492271	252	165	243	69	41	32	19	87	73	0	0.219	1.000	1.000
542	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(4), ABLIM1(4), ABLIM2(1), ABLIM3(3), ARHGEF12(2), CDC42(1), CFL1(1), CXCR4(1), DCC(4), DPYSL2(2), EFNA3(1), EFNB1(1), EFNB3(12), EPHA1(3), EPHA3(2), EPHA4(1), EPHA5(5), EPHA6(2), EPHA7(1), EPHA8(3), EPHB1(1), EPHB2(2), EPHB4(4), EPHB6(5), FES(3), FYN(2), GNAI1(1), GNAI2(1), GSK3B(3), HRAS(1), ITGB1(4), KRAS(1), L1CAM(5), LIMK1(4), LIMK2(2), MAPK3(1), MET(6), NCK1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NGEF(1), NRP1(2), NTN4(2), NTNG1(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PLXNA1(2), PLXNA2(2), PLXNA3(3), PLXNB1(4), PLXNB2(3), PLXNC1(3), PPP3CA(2), PPP3CC(3), PTK2(1), RAC3(1), RASA1(3), RGS3(3), RND1(2), ROBO1(2), ROBO2(5), ROBO3(1), ROCK1(4), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(2), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(1), SEMA4F(6), SEMA4G(2), SEMA5A(5), SEMA5B(1), SEMA6C(4), SEMA6D(3), SLIT1(2), SLIT2(7), SLIT3(5), SRGAP1(4), SRGAP2(1), SRGAP3(3), UNC5A(2), UNC5B(3), UNC5C(2), UNC5D(2)	125480090	251	156	222	62	18	28	21	83	100	1	0.531	1.000	1.000
543	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ARRB2(1), ATF1(2), ATF2(1), ATF4(2), ATF5(1), ATP2A2(6), ATP2A3(4), CALCA(1), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(3), CORIN(2), CRHR1(1), DGKZ(2), ETS2(1), FOS(1), GABPA(1), GABPB2(1), GBA2(3), GNB1(2), GNB3(2), GNB5(2), GNG3(1), GRK4(1), GRK5(1), GRK6(5), GSTO1(1), GUCA2A(1), GUCY1A3(2), IGFBP2(2), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL1B(1), ITPR1(4), ITPR2(9), ITPR3(4), JUN(2), MYL2(1), MYLK2(1), NFKB1(1), NOS1(9), NOS3(2), PDE4B(1), PDE4D(1), PKIA(1), PLCB3(2), PLCD1(1), PLCG1(2), PLCG2(2), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(1), RGS11(1), RGS17(2), RGS18(2), RGS2(2), RGS3(3), RGS6(2), RGS9(4), RLN1(1), RYR1(13), RYR2(11), RYR3(13), SLC8A1(1), SP1(2), TNXB(5), USP5(2), YWHAB(1)	112147180	229	155	222	55	34	32	19	79	65	0	0.160	1.000	1.000
544	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(1), ACVR1B(3), ACVR2A(1), ACVR2B(1), AMHR2(7), BMP2(1), BMP7(3), BMPR1B(1), BMPR2(5), CCL2(1), CCL27(1), CCL3(1), CCR6(1), CCR9(1), CD27(1), CLCF1(1), CSF1R(4), CSF2RA(2), CSF2RB(1), CSF3R(2), CX3CR1(1), CXCL11(1), CXCL9(1), CXCR4(1), CXCR6(1), EDA(1), EGF(4), EGFR(9), FAS(1), FLT1(7), FLT3(6), FLT4(7), GDF5(1), GH2(1), GHR(1), HGF(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNGR1(2), IFNGR2(2), IFNK(1), IL11RA(1), IL12RB1(2), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(1), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(3), IL19(2), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(4), IL20RA(1), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL6ST(3), IL9R(2), INHBA(2), INHBB(1), INHBC(1), INHBE(1), KDR(5), KITLG(2), LEP(1), LEPR(1), LIFR(2), LTA(1), LTB(1), LTBR(2), MET(6), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(5), PDGFRB(1), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(1), TGFBR2(1), TNFRSF10C(1), TNFRSF11B(1), TNFRSF13B(1), TNFRSF1A(1), TNFRSF21(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(6), TNFSF14(1), TNFSF15(1), TNFSF9(1), TPO(4), VEGFC(2), XCL1(1), XCR1(1)	115120482	223	153	209	41	16	30	21	88	68	0	0.0189	1.000	1.000
545	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(6), ACACB(4), AKT1(1), AKT2(3), AKT3(1), BRAF(2), CALM2(1), CBL(2), CBLB(2), CBLC(1), ELK1(1), EXOC7(4), FASN(3), FLOT2(1), FOXO1(1), G6PC(3), GRB2(2), GSK3B(3), GYS1(3), GYS2(1), HRAS(1), IKBKB(1), INPP5D(2), INSR(4), IRS1(4), IRS4(1), KRAS(1), LIPE(4), MAPK10(1), MAPK3(1), MAPK9(2), MKNK1(2), MKNK2(1), PCK1(4), PCK2(1), PDE3A(3), PDE3B(1), PFKL(1), PFKM(3), PFKP(2), PHKA1(5), PHKA2(3), PHKB(2), PHKG1(2), PHKG2(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPARGC1A(3), PPP1R3A(3), PPP1R3C(1), PPP1R3D(1), PRKAA2(4), PRKAB1(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAG2(4), PRKAR1A(2), PRKAR2B(2), PRKCI(2), PRKCZ(1), PTPN1(1), PTPRF(4), PYGB(2), PYGL(1), PYGM(3), RAF1(1), RAPGEF1(3), RHEB(3), RHOQ(1), RPS6KB1(2), RPS6KB2(2), SH2B2(1), SHC1(3), SHC2(1), SOCS3(1), SOCS4(1), SORBS1(1), SOS1(5), SOS2(3), SREBF1(2), TRIP10(1), TSC1(1), TSC2(5)	102633158	203	146	188	35	18	31	21	75	56	2	0.00462	1.000	1.000
546	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(1), AKT2(3), AKT3(1), CBL(2), CBLB(2), CBLC(1), CCND2(1), CLCF1(1), CREBBP(5), CSF2RA(2), CSF2RB(1), CSF3R(2), EP300(11), GH2(1), GHR(1), GRB2(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNGR1(2), IFNGR2(2), IFNK(1), IL11RA(1), IL12RB1(2), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(1), IL19(2), IL20RA(1), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL6ST(3), IL9R(2), IRF9(2), JAK1(4), JAK2(5), JAK3(3), LEP(1), LEPR(1), LIFR(2), OSMR(1), PIAS1(4), PIAS2(1), PIAS3(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRLR(2), PTPN11(1), PTPN6(3), SOCS3(1), SOCS4(1), SOCS5(1), SOS1(5), SOS2(3), SPRED1(6), SPRED2(1), SPRY1(1), SPRY2(2), SPRY4(10), STAM(2), STAT1(3), STAT2(6), STAT3(3), STAT4(1), STAT5A(2), STAT5B(2), STAT6(4), TPO(4), TYK2(6)	94558184	213	140	196	47	13	31	31	72	66	0	0.113	1.000	1.000
547	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(7), AXIN1(2), AXIN2(1), BTRC(2), CACYBP(3), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CHD8(3), CREBBP(5), CSNK1A1(2), CSNK2A2(1), CSNK2B(1), CTBP1(1), CTBP2(1), CTNNB1(1), CUL1(3), CXXC4(2), DAAM1(2), DVL1(1), DVL2(1), EP300(11), FBXW11(1), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD4(3), FZD5(1), GSK3B(3), JUN(2), LEF1(1), LRP5(3), LRP6(4), MAP3K7(1), MAPK10(1), MAPK9(2), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NKD1(2), NKD2(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), PPP3CA(2), PPP3CC(3), PRICKLE1(3), PRICKLE2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), RAC3(1), ROCK1(4), ROCK2(2), SENP2(1), SFRP2(1), SFRP4(2), SFRP5(1), SMAD2(2), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(3), TCF7L2(1), TP53(15), VANGL1(1), VANGL2(3), WIF1(4), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1)	102183611	203	136	191	51	12	22	25	75	67	2	0.358	1.000	1.000
548	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(2), CADM1(2), CADM3(1), CD2(2), CD22(4), CD28(1), CD34(2), CD4(10), CD6(2), CD86(1), CD8A(1), CDH1(1), CDH2(6), CDH3(3), CDH4(4), CDH5(3), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(1), CLDN4(2), CLDN6(1), CLDN7(1), CNTN1(4), CNTN2(2), CNTNAP1(7), CNTNAP2(5), CTLA4(1), ESAM(1), F11R(1), GLG1(4), HLA-B(1), HLA-C(2), HLA-DPA1(1), HLA-DPB1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(1), HLA-E(2), HLA-F(1), ICAM1(1), ICOS(2), ICOSLG(1), ITGA4(2), ITGA6(4), ITGA9(1), ITGAL(5), ITGAM(5), ITGAV(1), ITGB1(4), ITGB2(1), ITGB7(3), ITGB8(1), JAM3(1), L1CAM(5), MPZL1(1), NCAM2(1), NEGR1(2), NEO1(2), NFASC(5), NRCAM(2), NRXN1(7), NRXN2(3), NRXN3(3), OCLN(2), PTPRC(6), PTPRF(4), PTPRM(3), PVRL2(3), PVRL3(2), SDC3(1), SELE(4), SELP(2), SELPLG(2), SIGLEC1(2), SPN(1), VCAM1(3), VCAN(6)	93306626	196	133	185	61	15	26	22	75	57	1	0.801	1.000	1.000
549	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ADSL(1), ADSSL1(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(2), CANT1(1), ENPP3(1), ENTPD2(1), ENTPD5(1), GART(1), GDA(1), GMPR(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HPRT1(1), IMPDH1(1), NME7(1), NPR1(4), NPR2(4), NT5C1B(1), NT5C2(1), NT5M(2), NUDT5(3), NUDT9(1), PAPSS1(2), PAPSS2(2), PDE10A(1), PDE11A(5), PDE1A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(1), PDE8A(2), PDE8B(1), PDE9A(8), PFAS(2), POLA1(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLR1A(4), POLR1B(2), POLR1C(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(2), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(2), RFC5(1), RRM1(2), RRM2(1), XDH(5)	107731605	191	127	178	33	14	27	18	66	66	0	0.0210	1.000	1.000
550	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTB(1), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(2), ACVR1B(3), ACVR1C(3), CDC42(1), CDH1(1), CREBBP(5), CSNK2A2(1), CSNK2B(1), CTNNA1(4), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(5), EGFR(9), EP300(11), ERBB2(4), FARP2(2), FER(2), FGFR1(5), FYN(2), IGF1R(1), INSR(4), IQGAP1(3), LEF1(1), LMO7(10), MAP3K7(1), MAPK3(1), MET(6), MLLT4(8), PARD3(5), PTPN1(1), PTPN6(3), PTPRB(3), PTPRF(4), PTPRJ(7), PTPRM(3), PVRL2(3), PVRL3(2), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(2), SORBS1(1), SRC(1), SSX2IP(1), TCF7L2(1), TGFBR2(1), TJP1(2), VCL(2), WASF2(2), WASF3(2), WASL(6), YES1(1)	78785612	171	125	153	42	17	14	23	62	55	0	0.364	1.000	1.000
551	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ATF4(2), CACNA1C(9), CACNA1D(6), CACNA1F(4), CACNA1S(8), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), CGA(1), EGFR(9), ELK1(1), GNAS(5), GRB2(2), HRAS(1), ITPR1(4), ITPR2(9), ITPR3(4), JUN(2), KRAS(1), MAP2K3(2), MAP2K7(1), MAP3K1(5), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK9(2), MMP14(1), MMP2(6), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLD1(2), PLD2(5), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCD(3), PTK2B(3), RAF1(1), SOS1(5), SOS2(3), SRC(1)	84485985	180	125	176	45	23	27	19	71	40	0	0.139	1.000	1.000
552	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(4), ANAPC1(4), ANAPC2(1), ANAPC4(5), ANAPC5(1), ANAPC7(2), ATM(15), ATR(7), BUB1B(1), BUB3(1), CCNA1(7), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(2), CCNH(1), CDC14A(5), CDC16(3), CDC20(1), CDC23(2), CDC25A(1), CDC25B(1), CDC25C(2), CDC27(1), CDC6(1), CDC7(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), CHEK2(1), CREBBP(5), CUL1(3), E2F1(1), EP300(11), ESPL1(7), FZR1(3), GSK3B(3), HDAC1(2), MAD2L1(1), MCM2(6), MCM5(2), MCM6(3), MCM7(5), PCNA(2), PRKDC(10), RB1(2), RBL2(2), SKP2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMC1A(2), SMC1B(2), TGFB2(1), TP53(15), WEE1(1), YWHAB(1)	90202137	189	123	173	39	9	22	21	59	75	3	0.0795	1.000	1.000
553	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(1), BCAR1(3), CAPN1(1), CAPN10(1), CAPN11(1), CAPN2(2), CAPN3(6), CAPN6(2), CAPN7(1), CAPN9(2), CAV2(1), CDC42(1), CSK(3), DOCK1(1), FYN(2), GIT2(2), GRB2(2), ILK(4), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAD(9), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(3), ITGB1(4), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK4(1), MAPK7(1), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PIK3R2(2), PTK2(1), PXN(1), RAC3(1), RAPGEF1(3), RHO(1), ROCK1(4), ROCK2(2), SDCCAG8(1), SEPP1(1), SHC1(3), SORBS1(1), SOS1(5), SRC(1), TLN1(6), TNS1(7), VAV2(4), VCL(2), ZYX(1)	88189962	171	123	162	48	9	26	19	58	59	0	0.590	1.000	1.000
554	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), DRD1(1), DRD2(1), EGF(4), EGFR(9), GJD2(1), GNAI1(1), GNAI2(1), GNAS(5), GRB2(2), GRM1(4), GRM5(7), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HRAS(1), HTR2A(1), HTR2C(1), ITPR1(4), ITPR2(9), ITPR3(4), KRAS(1), MAP2K5(1), MAP3K2(2), MAPK3(1), MAPK7(1), NPR1(4), NPR2(4), PDGFC(1), PDGFD(2), PDGFRA(5), PDGFRB(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), PRKG1(3), PRKG2(2), RAF1(1), SOS1(5), SOS2(3), SRC(1), TJP1(2), TUBA1A(2), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2)	85841526	175	121	171	39	19	25	17	68	46	0	0.152	1.000	1.000
555	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(4), ACTN1(1), ACTR2(1), AKT1(1), AKT2(3), AKT3(1), ARHGEF6(2), ARHGEF7(4), BCAR1(3), BRAF(2), CDC42(1), CDKN2A(3), CSE1L(2), DOCK1(1), EPHB2(2), FYN(2), GRB2(2), GRB7(2), ILK(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), MAP2K7(1), MAP3K11(1), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PIK3CA(10), PIK3CB(3), PLCG1(2), PLCG2(2), PTEN(21), PTK2(1), RAF1(1), RALA(2), RHO(1), ROCK1(4), ROCK2(2), SHC1(3), SOS1(5), SOS2(3), SRC(1), TLN1(6), TLN2(8), ZYX(1)	79963137	177	120	168	39	8	31	17	57	62	2	0.127	1.000	1.000
556	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(3), ACTN4(2), DMD(7), MYBPC1(2), MYBPC2(3), MYH3(5), MYH6(4), MYH7(8), MYH8(5), MYL1(3), MYL2(1), MYL9(1), MYOM1(5), NEB(12), TMOD1(5), TNNI1(2), TNNT1(2), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TTN(83), VIM(1)	93467529	158	120	154	44	14	28	14	63	36	3	0.421	1.000	1.000
557	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), AKAP1(2), AKAP10(1), AKAP11(2), AKAP12(5), AKAP2(2), AKAP3(1), AKAP4(2), AKAP6(4), AKAP7(1), AKAP8(2), AKAP9(18), ARHGEF1(2), CALM2(1), CHMP1B(2), GNA12(1), GNA13(4), GNA15(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB1(2), GNB3(2), GNB5(2), GNG3(1), HRAS(1), IL18BP(1), ITPR1(4), KCNJ3(3), KRAS(1), PDE1A(1), PDE1B(5), PDE1C(1), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE8A(2), PDE8B(1), PLCB3(2), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKD3(3), SLC9A1(2), USP5(2)	76969295	168	119	162	38	18	22	5	68	54	1	0.204	1.000	1.000
558	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(1), ACTN2(3), ACTN4(2), ARHGAP5(4), BCAR1(3), CDC42(1), CDH5(3), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(1), CLDN4(2), CLDN6(1), CLDN7(1), CTNNA1(4), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(5), CXCR4(1), ESAM(1), EZR(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(1), ITGA4(2), ITGAL(5), ITGAM(5), ITGB1(4), ITGB2(1), ITK(1), JAM3(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(8), MMP2(6), MMP9(1), MSN(2), MYL2(1), MYL7(1), MYL9(1), NCF1(1), NCF2(1), NOX1(6), NOX3(4), OCLN(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCG(2), PTK2(1), PTK2B(3), PTPN11(1), PXN(1), RAP1A(1), RAPGEF3(1), RAPGEF4(1), ROCK1(4), ROCK2(2), SIPA1(1), VAV1(3), VAV2(4), VCAM1(3), VCL(2)	81195193	166	119	155	49	16	24	19	57	50	0	0.596	1.000	1.000
559	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM2(1), CDS2(1), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), FN3K(1), IMPA2(3), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5D(2), INPP5E(1), INPPL1(2), ITPK1(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), OCRL(2), PI4KA(9), PI4KB(3), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3C3(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PRKCA(2), PRKCG(2), PTEN(21), PTPMT1(1), SYNJ1(5), SYNJ2(5)	82461019	170	117	162	44	14	28	12	56	58	2	0.362	1.000	1.000
560	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(2), CACNA1A(5), CRHR1(1), GNA12(1), GNA13(4), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(5), GNAZ(1), GRIA1(6), GRIA2(3), GRIA3(2), GRID2(6), GRM1(4), GRM5(7), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HRAS(1), IGF1R(1), ITPR1(4), ITPR2(9), ITPR3(4), KRAS(1), MAPK3(1), NOS1(9), NOS3(2), NPR1(4), NPR2(4), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), PRKCA(2), PRKCG(2), PRKG1(3), PRKG2(2), RAF1(1), RYR1(13)	72272749	152	115	150	44	24	16	9	61	41	1	0.548	1.000	1.000
561	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BID(1), BRAF(2), CD48(1), FAS(1), FYN(2), GRB2(2), HCST(1), HLA-B(1), HLA-C(2), HLA-E(2), HRAS(1), ICAM1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNGR1(2), IFNGR2(2), ITGAL(5), ITGB2(1), KIR2DL3(1), KIR3DL1(3), KLRC1(2), KLRC2(3), KLRC3(1), KRAS(1), LCP2(1), MAPK3(1), MICA(1), MICB(2), NCR1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PAK1(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PPP3CA(2), PPP3CC(3), PRF1(1), PRKCA(2), PRKCG(2), PTK2B(3), PTPN11(1), PTPN6(3), RAC3(1), RAF1(1), SH2D1B(1), SH3BP2(2), SHC1(3), SHC2(1), SOS1(5), SOS2(3), SYK(1), TNFRSF10C(1), TNFSF10(6), ULBP2(1), VAV1(3), VAV2(4)	72635902	158	114	147	36	8	28	17	57	47	1	0.235	1.000	1.000
562	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR6(1), CCR9(1), CHML(1), CHRM2(3), CHRM3(2), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(2), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(3), F2RL1(1), F2RL2(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(1), GPR174(2), GPR35(2), GPR37(1), GPR37L1(1), GPR4(1), GPR50(1), GPR63(1), GPR83(1), GPR85(2), GPR87(1), GRPR(1), HRH2(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), MAS1(1), MC1R(2), MC3R(2), MC4R(1), MC5R(1), MTNR1B(1), NMUR2(4), NTSR1(1), OPN1SW(2), OPRD1(2), OPRL1(1), OPRM1(3), OR12D3(1), OR1C1(1), OR1F1(1), OR5V1(2), OR7A5(1), OR7C1(2), OR8B8(2), P2RY1(1), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), PTAFR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), RHO(1), SSTR1(1), SSTR3(1), SSTR4(1), TBXA2R(2), TRHR(2)	74811985	139	110	137	46	23	19	15	55	27	0	0.496	1.000	1.000
563	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(2), ALG1(1), ALG10(3), ALG10B(6), ALG11(3), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG6(2), ALG8(1), B3GNT1(1), B3GNT2(3), B3GNT6(1), B3GNT7(1), B4GALT3(2), B4GALT4(2), B4GALT5(1), CHST1(2), CHST11(1), CHST12(2), CHST14(1), CHST2(1), CHST4(1), CHST7(1), CHSY1(8), DPAGT1(5), EXT1(3), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), FUT11(1), GALNT1(1), GALNT10(5), GALNT11(2), GALNT13(3), GALNT14(1), GALNT2(1), GALNT4(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST5(1), HS6ST1(1), HS6ST2(1), MAN1A1(2), MAN1A2(1), MAN2A1(3), MGAT4A(3), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(2), NDST2(3), NDST4(5), OGT(4), RPN1(2), RPN2(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1), ST6GALNAC1(2), STT3B(3), WBSCR17(3), XYLT1(2), XYLT2(2)	70053130	161	109	144	41	5	26	13	52	65	0	0.551	1.000	1.000
564	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2A(1), AMY2B(1), ASCC3(5), ATP13A2(4), DDX18(3), DDX23(2), DDX4(3), DDX50(5), DDX52(1), DDX54(1), DDX55(2), DHX58(1), ENPP3(1), EP400(8), ERCC2(1), ERCC3(1), G6PC(3), GAA(1), GANC(2), GBA(2), GPI(3), GUSB(5), GYS1(3), GYS2(1), HK1(5), IFIH1(1), MGAM(5), MOV10L1(5), NUDT5(3), PYGB(2), PYGL(1), PYGM(3), RAD54L(2), RUVBL2(2), SETX(7), SI(6), SMARCA2(5), SMARCA5(1), UGP2(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), UXS1(1)	81764248	142	107	136	47	7	22	18	42	53	0	0.866	1.000	1.000
565	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(4), ABCA12(7), ABCA13(17), ABCA2(2), ABCA3(3), ABCA4(7), ABCA5(5), ABCA6(3), ABCA7(7), ABCA8(4), ABCA9(3), ABCB1(4), ABCB11(3), ABCB4(5), ABCB5(3), ABCB6(1), ABCB8(1), ABCC1(8), ABCC10(4), ABCC11(5), ABCC12(2), ABCC2(1), ABCC3(7), ABCC4(5), ABCC5(2), ABCC6(5), ABCC8(4), ABCC9(3), ABCD2(1), ABCD3(2), ABCD4(3), ABCG1(1), ABCG4(5), ABCG5(2), ABCG8(3), CFTR(4), TAP2(1)	77455409	153	106	142	38	6	24	19	60	43	1	0.239	1.000	1.000
566	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(3), AKT1(1), BMPR2(5), CDKL1(1), CDS2(1), CLK1(4), CLK2(2), CLK4(3), COL4A3BP(2), CSNK2A2(1), CSNK2B(1), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKB(2), MAP3K10(3), MOS(1), NEK1(3), NEK3(3), OCRL(2), PAK4(2), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3CA(10), PIK3CB(3), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCG1(2), PLCG2(2), PLK3(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKG1(3), RAF1(1), RPS6KA1(7), RPS6KA4(1), RPS6KB1(2)	74646129	145	106	136	32	10	23	7	50	54	1	0.235	1.000	1.000
567	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(4), ATM(15), BUB1B(1), BUB3(1), CCNA1(7), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(2), CCNH(1), CDAN1(4), CDC14A(5), CDC20(1), CDC25A(1), CDC25B(1), CDC25C(2), CDC6(1), CDC7(1), CDH1(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CHEK2(1), DTX4(4), E2F1(1), E2F5(1), EP300(11), ESPL1(7), GSK3B(3), HDAC1(2), HDAC4(1), HDAC6(2), MAD2L1(1), MCM2(6), MCM5(2), MCM6(3), MCM7(5), PCNA(2), PRKDC(10), PTPRA(3), RB1(2), SKP2(1), SMAD4(1), TBC1D8(1), TP53(15), WEE1(1)	73140385	157	99	143	36	9	19	22	47	57	3	0.135	1.000	1.000
568	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(1), CLK2(2), CLK3(1), CLK4(3), COL2A1(5), CPSF1(3), CPSF2(2), CPSF3(4), CPSF4(2), CSTF2T(1), CSTF3(4), DDX1(1), DDX20(4), DHX15(2), DHX16(1), DHX8(2), DHX9(3), DICER1(3), FUS(5), GIPC1(1), METTL3(4), NONO(2), NUDT21(1), NXF1(1), PAPOLA(2), POLR2A(8), PPM1G(1), PRPF3(2), PRPF4B(3), PRPF8(11), PSKH1(1), PTBP1(1), PTBP2(1), RBM17(1), RBM5(1), RNMT(1), SF3A1(1), SF3A3(1), SF3B1(7), SF3B2(2), SNRPB(1), SNRPN(2), SPOP(1), SRPK2(2), SRRM1(2), SUPT5H(4), TXNL4A(1), U2AF2(2), XRN2(2)	69462013	120	98	117	31	8	29	9	41	32	1	0.347	1.000	1.000
569	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(3), AKT3(1), FYN(2), GAB2(1), GRB2(2), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(1), LCP2(1), MAP2K3(2), MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MS4A2(1), PDK1(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG1(2), PLCG2(2), PRKCA(2), PRKCD(3), PRKCE(2), RAC3(1), RAF1(1), SOS1(5), SOS2(3), SYK(1), VAV1(3), VAV2(4)	47420285	87	77	82	26	7	19	13	33	15	0	0.399	1.000	1.000
570	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(3), AKT3(1), CASP9(1), CDC42(1), HRAS(1), KDR(5), KRAS(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NOS3(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG1(2), PLCG2(2), PPP3CA(2), PPP3CC(3), PRKCA(2), PRKCG(2), PTGS2(4), PTK2(1), PXN(1), RAC3(1), RAF1(1), SH2D2A(1), SHC2(1), SPHK2(1), SRC(1)	46331947	96	76	89	29	6	17	9	41	23	0	0.599	1.000	1.000
571	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), ASCC3(5), ATP13A2(4), DDX18(3), DDX23(2), DDX4(3), DDX50(5), DDX52(1), DDX54(1), DDX55(2), DHX58(1), EP400(8), ERCC2(1), ERCC3(1), FPGS(2), IFIH1(1), MOV10L1(5), NUDT5(3), QDPR(1), RAD54L(2), RUVBL2(2), SETX(7), SMARCA2(5), SMARCA5(1)	40685480	76	64	73	22	2	16	9	21	28	0	0.502	1.000	1.000
572	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), CDC42(1), CHUK(1), CSK(3), EGFR(9), F11R(1), GIT1(1), IGSF5(4), IKBKB(1), JAM3(1), JUN(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(6), NFKB1(1), NFKB2(1), NOD1(1), PAK1(2), PLCG1(2), PLCG2(2), PTPN11(1), PTPRZ1(9), RELA(5), SRC(1), TJP1(2)	46433030	85	64	75	20	6	12	9	31	26	1	0.481	1.000	1.000
573	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(3), APAF1(2), ARHGDIB(1), BAG4(1), BID(1), BIRC2(2), BIRC3(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), DAXX(5), DFFB(1), GSN(2), LMNB1(3), MAP2K7(1), MAP3K1(5), MAP3K5(5), NFKB1(1), NUMA1(3), PAK2(2), PRKCD(3), PRKDC(10), PSEN2(2), PTK2(1), RASA1(3), RB1(2), RELA(5), RIPK1(1), SPTAN1(6), TNFRSF1A(1), TRADD(2), TRAF2(1)	45462088	83	63	80	19	3	17	10	28	24	1	0.160	1.000	1.000
574	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(5), ATP4A(5), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), COX10(2), COX15(1), COX17(1), COX6B2(1), CYC1(1), NDUFA1(1), NDUFA10(1), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFB2(1), NDUFB6(1), NDUFC1(2), NDUFS1(5), NDUFS2(1), NDUFS3(2), NDUFS5(1), NDUFS6(1), NDUFS8(1), NDUFV1(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SDHD(1), UQCRC1(1), UQCRC2(1), UQCRFS1(1)	36695426	71	61	70	22	5	10	9	29	18	0	0.702	1.000	1.000
575	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(9), EEF1A2(1), EEF1G(1), EEF2K(1), EIF2AK1(1), EIF2AK2(4), EIF2AK3(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(2), EIF2S2(2), EIF4A2(3), EIF4E(1), EIF4G1(3), EIF4G3(3), EIF5(2), EIF5A(2), ETF1(2), PABPC1(9), PABPC3(7), PAIP1(3), SLC35A4(2)	28841964	63	56	63	23	7	11	6	23	16	0	0.831	1.000	1.000
576	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(7), AXIN1(2), CCND2(1), CTNNB1(1), DVL1(1), DVL2(1), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD5(1), GSK3B(3), JUN(2), LDLR(1), MAPK10(1), MAPK9(2), PAFAH1B1(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(1), PRKD1(3), SFRP4(2), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT5B(1), WNT7B(1)	37193972	62	56	59	21	5	13	6	20	18	0	0.716	1.000	1.000
577	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2A(1), AMY2B(1), ENPP3(1), G6PC(3), GAA(1), GPI(3), GUSB(5), GYS1(3), GYS2(1), HK1(5), MGAM(5), PYGB(2), PYGL(1), PYGM(3), RNPC3(1), SI(6), UCHL3(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2), UXS1(1)	37840880	63	53	60	20	5	9	8	19	22	0	0.746	1.000	1.000
578	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(1), ACTG1(3), ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(1), EZR(1), FYN(2), HCLS1(1), ITGB1(4), LY96(1), NCK1(1), NCL(3), OCLN(2), PRKCA(2), ROCK1(4), ROCK2(2), TLR4(2), TLR5(2), TUBA1A(2), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2), WASL(6)	33048574	63	52	62	23	3	14	9	21	16	0	0.856	1.000	1.000
579	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(1), ACTG1(3), ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(1), EZR(1), FYN(2), HCLS1(1), ITGB1(4), LY96(1), NCK1(1), NCL(3), OCLN(2), PRKCA(2), ROCK1(4), ROCK2(2), TLR4(2), TLR5(2), TUBA1A(2), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2), WASL(6)	33048574	63	52	62	23	3	14	9	21	16	0	0.856	1.000	1.000
580	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH4A1(1), AOC2(3), AOC3(1), ARG1(1), ASL(4), CPS1(4), DAO(1), GATM(1), GOT1(3), GOT2(2), MAOA(1), NOS1(9), NOS3(2), OAT(1), ODC1(2), OTC(1), P4HA1(3), P4HA2(1), PYCR1(1), RARS(2), SMS(2)	28582659	55	50	53	18	3	5	11	17	19	0	0.800	1.000	1.000
581	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(2), CARS(6), CARS2(3), DARS(1), DARS2(1), EPRS(2), FARSA(1), HARS(1), HARS2(1), IARS(4), IARS2(2), LARS(3), LARS2(2), MARS(2), MARS2(3), NARS2(4), PARS2(3), QARS(1), RARS(2), SARS(2), TARS(5), TARS2(5), VARS(2), VARS2(2), WARS(1), WARS2(1), YARS(1)	34829011	65	50	61	16	1	11	7	27	19	0	0.458	1.000	1.000
582	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(1), F12(3), F13B(2), F2(2), F5(7), F7(1), F8(5), F9(2), FGA(2), FGB(1), FGG(5), LPA(6), PLAT(4), PLG(5), SERPINF2(2), VWF(11)	22827589	59	49	55	19	4	3	11	20	19	2	0.681	1.000	1.000
583	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(1), CDS2(1), CHAT(4), CHKB(2), CHPT1(2), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(1), ETNK1(2), GPAM(2), LCAT(1), LYPLA1(1), PCYT1A(1), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(5), PNPLA3(2), PPAP2B(1), PPAP2C(2), PTDSS1(2), SH3GLB1(2)	42731591	58	48	54	15	8	7	4	17	22	0	0.511	1.000	1.000
584	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), AOC2(3), AOC3(1), AOX1(7), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(3), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2J2(3), CYP3A7(1), CYP4B1(3), DDC(2), ECHS1(2), EHHADH(5), GCDH(3), HAAO(1), HADHA(2), MAOA(1), TPH1(1), WARS(1), WARS2(1)	35913132	61	48	56	21	6	10	7	20	18	0	0.795	1.000	1.000
585	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK14(1), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), RAF1(1), SHC1(3), SOS1(5), SYK(1), SYT1(1), VAV1(3)	24547456	53	46	50	19	6	8	4	16	19	0	0.876	1.000	1.000
586	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), ATP8A1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR6(1), CX3CR1(1), CXCR4(1), CXCR6(1), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GRPR(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NTSR1(1), OPRD1(2), OPRL1(1), OPRM1(3), SSTR1(1), SSTR3(1), SSTR4(1), TACR1(1), TACR3(2), TRHR(2), TSHR(2)	32739361	55	44	55	18	13	7	6	19	10	0	0.437	1.000	1.000
587	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(5), CREBBP(5), EP300(11), ERCC3(1), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC6(2), NCOR2(6), NRIP1(4), PELP1(1), POLR2A(8), TBP(1)	30162873	51	43	48	16	2	6	8	17	18	0	0.643	1.000	1.000
588	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKB(2), MIOX(2), OCRL(2), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3CA(10), PIK3CB(3), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCG1(2), PLCG2(2)	29634825	50	43	46	15	1	7	3	22	17	0	0.827	1.000	1.000
589	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(2), ALOX15B(2), ALOX5(2), CBR1(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2J2(3), CYP2U1(1), CYP4A11(4), CYP4F2(2), DHRS4(3), EPHX2(1), GGT1(2), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3)	25276434	48	42	46	14	4	6	12	12	13	1	0.483	1.000	1.000
590	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), AKT1(1), DGKA(2), GCA(2), ITGA9(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(3), PDE3B(1), PIK3C2G(2), PIK3CA(10), PIK3CD(1), PIK3R1(2)	32164513	49	42	46	13	6	11	5	17	10	0	0.247	1.000	1.000
591	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(1), GALNT1(1), GALNT10(5), GALNT11(2), GALNT13(3), GALNT14(1), GALNT2(1), GALNT4(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(4), ST3GAL1(1), ST6GALNAC1(2), WBSCR17(3)	21376454	43	41	40	18	1	5	6	19	12	0	0.962	1.000	1.000
592	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPS(1), CDS2(1), CHAT(4), CHKB(2), CLC(2), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), ETNK1(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(1), PISD(1), PLA2G4A(1), PLA2G6(2), PLCB2(2), PLCG1(2), PLCG2(2), PPAP2B(1), PPAP2C(2)	32534496	46	39	43	17	6	9	2	11	18	0	0.803	1.000	1.000
593	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(4), AR(1), ESR2(2), NR1D2(1), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2F2(2), NR4A2(1), NR5A2(2), PGR(2), PPARD(1), PPARG(2), RARA(4), RARB(2), RORA(2), RORC(1), RXRB(4), RXRG(2), THRA(1), VDR(1)	26236564	40	38	40	15	6	3	9	13	9	0	0.810	1.000	1.000
594	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(3), ACTG2(1), ADCY3(3), ADCY9(4), ARF1(1), ARF3(1), ARF6(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1D(1), ATP6V1G1(1), GNAS(5), PLCG1(2), PLCG2(2), PRKCA(2), SEC61B(1), TRIM23(3)	24292078	42	37	41	14	1	6	5	16	14	0	0.881	1.000	1.000
595	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(3), JAK1(4), JAK2(5), JAK3(3), JUN(2), MAPK3(1), PTPN11(1), RAF1(1), SHC1(3), SOS1(5), STAT3(3)	15363821	38	35	38	13	3	4	6	15	10	0	0.860	1.000	1.000
596	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CXCR4(1), GNAI1(1), GNB1(2), HRAS(1), MAPK3(1), NFKB1(1), PIK3C2G(2), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(1), PTK2B(3), PXN(1), RAF1(1), RELA(5)	18409884	39	34	32	15	1	10	2	15	10	1	0.890	1.000	1.000
597	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(1), ALDOB(3), FPGT(1), GMDS(1), GMPPA(1), GMPPB(1), HK1(5), KHK(3), MPI(1), PFKFB3(1), PFKM(3), PFKP(2), SORD(10), TPI1(1)	15651531	37	34	30	12	5	2	4	6	20	0	0.913	1.000	1.000
598	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM2(1), GRB2(2), HRAS(1), JUN(2), MAP2K3(2), MAP3K1(5), MAPK14(1), MAPK3(1), PAK1(2), PLCG1(2), PRKCA(2), PTK2B(3), RAF1(1), SHC1(3), SOS1(5), SRC(1), SYT1(1)	18578940	38	34	37	12	3	8	1	15	11	0	0.813	1.000	1.000
599	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	DLG4(1), EPHB2(2), F2(2), F2RL1(1), F2RL2(1), JUN(2), MAP2K5(1), MAPK7(1), PLD1(2), PLD2(5), PLD3(3), PTK2(1), RAF1(1), RASAL1(5), SRC(1), TEC(5), VAV1(3)	17863193	37	34	32	12	4	1	3	16	13	0	0.923	1.000	1.000
600	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), G6PC(3), GAA(1), GALK1(1), GALK2(1), GALT(3), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(2), MGAM(5), PFKM(3), PFKP(2)	21050291	36	33	35	13	3	5	4	9	15	0	0.843	1.000	1.000
601	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(2), AKT1(1), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(1), ITGB3(1), MAPK3(1), PDGFRA(5), PIK3CA(10), PIK3R1(2), PLCB1(1), PRKCA(2), PTK2(1), SMPD2(2), SRC(1)	18022500	34	31	31	14	2	10	3	12	7	0	0.856	1.000	1.000
602	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(3), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2J2(3), CYP3A7(1), CYP4B1(3)	18605266	35	31	35	11	6	8	1	14	6	0	0.472	1.000	1.000
603	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), JAK1(4), JAK3(3), JUN(2), MAPK3(1), RAF1(1), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2), SYK(1)	15080632	33	31	32	11	4	5	4	11	9	0	0.764	1.000	1.000
604	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22RA1(1), IL22RA2(1), JAK1(4), JAK2(5), JAK3(3), SOCS3(1), STAT1(3), STAT3(3), STAT5A(2), STAT5B(2), TYK2(6)	11937463	31	30	29	12	1	0	5	12	13	0	0.977	1.000	1.000
605	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(4), ADRB2(2), CHRM2(3), CHRM3(2), CHRM5(2), DRD1(1), DRD2(1), DRD3(2), DRD5(1), HRH2(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2)	15949244	33	30	31	15	5	3	2	14	9	0	0.908	1.000	1.000
606	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CFL1(1), GNAS(5), GNB1(2), HRAS(1), LIMK1(4), MAPK3(1), MYL2(1), NOX1(6), PIK3C2G(2), PLCB1(1), PPP1R12B(1), PRKCA(2), PTK2(1), RAF1(1), ROCK2(2)	16827317	31	28	27	11	1	2	1	15	12	0	0.975	1.000	1.000
607	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(2), ANXA4(2), ANXA6(2), CYP11A1(1), EDNRB(3), HPGD(1), PLA2G4A(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), PTGS1(2), PTGS2(4), TBXAS1(3)	13322619	28	28	28	14	2	4	4	10	7	1	0.953	1.000	1.000
608	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(1), ACTN2(3), CAPN1(1), ITGA1(5), ITGB1(4), ITGB3(1), PTK2(1), PXN(1), SPTAN1(6), SRC(1), TLN1(6)	18685380	30	28	29	12	2	3	1	12	12	0	0.954	1.000	1.000
609	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CDKN1A(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1)	13047876	31	27	28	11	2	5	2	7	15	0	0.901	1.000	1.000
610	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), LCAT(1), LDLR(1), LIPC(1), LPL(2), LRP1(11), SCARB1(1), SOAT1(4)	17613083	27	26	25	10	2	5	3	7	10	0	0.758	1.000	1.000
611	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), GNAI1(1), GNB1(2), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), PLA2G4A(1), PLCB1(1), PRKCA(2), PTGS1(2), PTK2(1), RAF1(1), SRC(1), SYK(1), TBXAS1(3)	16063605	29	25	28	15	2	4	3	8	11	1	0.984	1.000	1.000
612	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(3), BCAR1(3), CSK(3), CTNNA1(4), CTNNA2(4), CTNNB1(1), PTK2(1), PXN(1), SRC(1), VCL(2)	12436358	24	23	24	13	3	3	3	12	3	0	0.973	1.000	1.000
613	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(5), GALNT2(1), GALNT4(1), GALNT6(1), GALNT7(5), GALNT9(1), GCNT1(2), ST3GAL1(1), ST3GAL4(1), WBSCR17(3)	9626314	22	22	19	14	0	1	5	6	10	0	0.998	1.000	1.000
614	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(1), XYLT1(2), XYLT2(2)	3749783	6	6	6	5	1	3	0	2	0	0	0.859	1.000	1.000
615	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(1), XYLT1(2), XYLT2(2)	3749783	6	6	6	5	1	3	0	2	0	0	0.859	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		341605	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
