rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(2), CDKN2A(11), E2F1(3), MDM2(1), MYC(2), PIK3CA(13), PIK3R1(4), POLR1A(7), POLR1B(2), POLR1C(1), RB1(24), TBX2(2), TP53(117), TWIST1(2)	11429598	191	151	153	6	11	22	10	63	84	1	8.07e-12	<1.00e-15	<1.14e-13
2	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(12), AXIN1(25), BTRC(5), CCND1(1), CREBBP(6), CSNK1A1(2), CSNK2A1(2), CTBP1(1), CTNNB1(102), DVL1(3), FZD1(2), GSK3B(3), MAP3K7(3), MYC(2), NLK(2), PPP2CA(2), TLE1(6), WIF1(6), WNT1(2)	17083595	187	151	110	14	2	47	21	75	41	1	2.99e-09	<1.00e-15	<1.14e-13
3	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), APAF1(9), ATM(9), BAX(3), BCL2(1), CASP3(3), CASP6(2), CASP9(1), PRKCA(1), PTK2(9), PXN(2), STAT1(5), TLN1(10), TP53(117)	15287002	174	142	141	7	12	33	10	57	62	0	4.57e-11	<1.00e-15	<1.14e-13
4	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(6), DAXX(1), PAX3(4), PML(2), RARA(1), RB1(24), SIRT1(2), SP100(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TP53(117)	10745023	161	135	128	11	7	21	8	51	73	1	8.34e-07	<1.00e-15	<1.14e-13
5	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CCND1(1), CDKN1A(6), CDKN1B(5), CDKN2A(11), CFL1(1), E2F1(3), MDM2(1), TP53(117)	4705549	146	134	113	4	7	17	7	54	61	0	2.63e-10	<1.00e-15	<1.14e-13
6	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(2), ATM(9), BRCA1(9), CDKN1A(6), CHEK1(5), CHEK2(5), JUN(2), MAPK8(1), MDM2(1), NFKB1(3), NFKBIA(2), RAD50(6), RAD51(2), RBBP8(3), RELA(4), TP53(117), TP73(2)	16637482	179	147	147	14	11	25	13	62	67	1	1.43e-06	1.11e-15	1.14e-13
7	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(8), EIF2S2(1), NFKB1(3), NFKBIA(2), RELA(4), TP53(117)	5747826	135	122	103	8	7	20	10	44	54	0	7.56e-07	1.67e-15	1.18e-13
8	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), BCL2(1), EGFR(6), IGF1R(11), MYC(2), POLR2A(7), PPP2CA(2), PRKCA(1), RB1(24), TEP1(13), TERF1(5), TERT(2), TNKS(3), TP53(117), XRCC5(4)	15748769	200	159	166	15	9	31	10	64	85	1	1.43e-07	1.78e-15	1.18e-13
9	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(2), ATM(9), ATR(15), CCNA1(3), CCND1(1), CCNE1(1), CDK6(1), CDKN1A(6), CDKN1B(5), CDKN2A(11), CDKN2B(1), E2F1(3), GSK3B(3), RB1(24), SKP2(1), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(2), TP53(117)	17015204	212	161	178	12	9	25	9	80	87	2	4.16e-09	1.89e-15	1.18e-13
10	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(9), ATR(15), BRCA1(9), CCNB1(2), CDC25B(2), CDC25C(3), CDC34(1), CDKN1A(6), CHEK1(5), CHEK2(5), EP300(11), MDM2(1), MYT1(2), PRKDC(6), RPS6KA1(1), TP53(117), WEE1(2)	24294020	197	162	164	16	11	25	15	73	71	2	2.92e-07	2.11e-15	1.18e-13
11	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(9), ATR(15), CDC25C(3), CHEK1(5), CHEK2(5), TP53(117)	8848082	154	134	122	5	10	18	9	57	59	1	5.80e-09	2.11e-15	1.18e-13
12	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(5), APC(12), AXIN1(25), BTRC(5), CTNNB1(102), DLL1(2), DVL1(3), FZD1(2), GSK3B(3), NOTCH1(7), PSEN1(2), WNT1(2)	12478365	170	141	94	12	5	42	23	68	31	1	1.60e-09	2.55e-15	1.31e-13
13	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(8), AKT1(2), ATM(9), BAX(3), CDKN1A(6), CPB2(2), CSNK1A1(2), HIF1A(3), IGFBP3(2), MAPK8(1), MDM2(1), NQO1(2), TP53(117)	12220206	158	140	124	7	10	21	9	61	57	0	5.17e-09	2.89e-15	1.32e-13
14	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	APAF1(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), CASP3(3), CASP6(2), CASP8(1), CASP9(1), FADD(1), FAS(3), GZMB(2), JUN(2), MAP2K4(4), MAP3K1(3), MAPK10(3), MCL1(2), MDM2(1), MYC(2), NFKB1(3), NFKBIA(2), PARP1(5), PRF1(4), RELA(4), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF10(1), TP53(117), TRAF1(1)	21472534	192	151	157	17	12	37	15	59	69	0	5.97e-07	3.00e-15	1.32e-13
15	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(9), ATM(9), BAX(3), BCL2(1), CCND1(1), CCNE1(1), CDKN1A(6), E2F1(3), MDM2(1), RB1(24), TIMP3(1), TP53(117)	10184630	176	145	142	7	10	23	7	62	73	1	6.42e-10	3.33e-15	1.37e-13
16	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(4), ACTN2(6), BCAR1(3), CSK(1), CTNNA1(3), CTNNA2(10), CTNNB1(102), PTK2(9), PXN(2), SRC(3), VCL(3)	11003664	146	118	71	8	2	40	22	69	13	0	1.68e-09	3.55e-15	1.37e-13
17	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(12), AXIN1(25), CCND1(1), CTNNB1(102), DVL1(3), FZD1(2), GJA1(1), GNAI1(4), GSK3B(3), IRAK1(5), LBP(3), LEF1(2), LY96(1), MYD88(1), NFKB1(3), PDPK1(1), PIK3CA(13), PIK3R1(4), PPP2CA(2), RELA(4), TIRAP(2), TLR4(5), WNT1(2)	17645121	203	159	122	19	2	52	28	75	45	1	1.02e-08	3.89e-15	1.37e-13
18	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(9), CDC25B(2), CDC25C(3), CHEK1(5), MYT1(2), RB1(24), TP53(117), WEE1(2)	9995560	164	138	131	6	9	17	9	53	75	1	2.98e-09	4.00e-15	1.37e-13
19	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), IFNG(3), IFNGR1(3), IFNGR2(1), IKBKB(4), JAK2(4), NFKB1(3), NFKBIA(2), RB1(24), RELA(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TP53(117), USH1C(2), WT1(6)	10997721	177	140	144	15	8	24	11	58	75	1	2.93e-06	4.22e-15	1.37e-13
20	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(12), AXIN1(25), CREBBP(6), CTNNB1(102), DVL1(3), EP300(11), FZD1(2), GSK3B(3), LDB1(3), LEF1(2), PITX2(1), TRRAP(9), WNT1(2)	18615696	181	144	104	18	3	49	22	70	36	1	2.49e-07	4.77e-15	1.47e-13
21	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(12), ATF2(1), AXIN1(25), BMP2(2), BMP4(1), BMP5(4), BMP7(3), BMPR1A(1), BMPR2(5), CHRD(2), CTNNB1(102), DVL1(3), FZD1(2), GSK3B(3), MAP3K7(3), MEF2C(1), NKX2-5(1), NPPB(1), RFC1(7), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), WNT1(2)	20808386	192	152	114	20	7	48	23	74	39	1	2.25e-07	5.00e-15	1.47e-13
22	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MYC(2), SP1(2), SP3(3), TP53(117), WT1(6)	4048085	130	125	98	3	9	17	10	42	52	0	1.22e-10	5.77e-15	1.62e-13
23	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(9), ATM(9), ATR(15), BAI1(5), BAX(3), CASP3(3), CASP8(1), CASP9(1), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(1), CCND2(3), CCNE1(1), CCNE2(2), CCNG1(1), CD82(3), CDK6(1), CDKN1A(6), CDKN2A(11), CHEK1(5), CHEK2(5), DDB2(3), EI24(2), FAS(3), GADD45G(1), GTSE1(3), IGFBP3(2), MDM2(1), MDM4(1), PPM1D(2), PTEN(11), RCHY1(1), RFWD2(4), RPRM(1), SERPINE1(1), SESN1(1), SESN2(3), SESN3(2), SIAH1(4), STEAP3(2), THBS1(6), TNFRSF10B(2), TP53(117), TP73(2), TSC2(12), ZMAT3(1)	37462249	280	192	245	25	18	45	19	96	101	1	4.18e-09	7.56e-14	2.02e-12
24	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(2), AKT2(3), AKT3(2), ANKRD6(3), APC(12), AXIN1(25), AXIN2(6), CER1(1), CSNK1A1(2), CTNNB1(102), DACT1(3), DKK1(1), DKK2(4), DKK3(4), DVL1(3), GSK3A(1), GSK3B(3), LRP1(19), MVP(2), NKD1(2), NKD2(3), PIN1(2), PSEN1(2), PTPRA(4), SENP2(3), WIF1(6)	23049473	220	158	141	24	2	52	29	86	49	2	5.76e-07	1.59e-12	4.09e-11
25	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(9), ATR(15), BRCA1(9), BRCA2(10), CHEK1(5), CHEK2(5), FANCA(4), FANCC(1), FANCD2(3), FANCE(3), FANCF(3), FANCG(1), HUS1(1), RAD1(1), RAD17(1), RAD50(6), RAD51(2), RAD9A(2), TP53(117), TREX1(1)	24593084	199	153	167	20	12	32	16	70	67	2	5.16e-06	8.92e-12	2.20e-10
26	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), ATF2(1), CDC42(3), DLD(4), DUSP4(1), DUSP8(2), GAB1(3), IL1R1(4), JUN(2), MAP2K4(4), MAP2K5(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K13(4), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPK10(3), MAPK7(3), MAPK8(1), MAPK9(3), MYEF2(3), NFATC3(4), NR2C2(2), PAPPA(5), SHC1(3), TP53(117), TRAF6(2), ZAK(3)	28465635	211	155	179	19	16	35	18	67	74	1	4.53e-08	1.90e-11	4.50e-10
27	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(3), CCNB1(2), CCND1(1), CCND2(3), CCNE1(1), CCNH(1), CDK6(1), CDKN1A(6), CDKN1B(5), CDKN2A(11), CDKN2B(1), CDKN2C(2), E2F1(3), RB1(24), RBL1(4), TFDP1(2)	9084342	70	60	68	3	1	6	5	25	32	1	0.000224	3.59e-10	8.20e-09
28	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(1), JUN(2), KEAP1(19), MAPK1(3), MAPK14(3), MAPK8(1), NFE2L2(15), PRKCA(1)	5218897	46	41	43	0	4	9	4	18	11	0	2.60e-05	3.12e-09	6.87e-08
29	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(9), CCNA1(3), CCNB1(2), CCND1(1), CCND2(3), CCNE1(1), CCNE2(2), CCNH(1), CDKN1A(6), CDKN1B(5), CDKN1C(2), CDKN2A(11), CDKN2B(1), CDKN2C(2), CREB3L1(2), CREB3L3(5), CREB3L4(3), E2F1(3), E2F3(2), E2F4(2), E2F6(2), GBA2(1), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), MDM2(1), MYC(2), MYT1(2), NACA(5), POLE(4), POLE2(4), PRIM1(3), RB1(24), RBL1(4), RPA1(1), RPA2(2), TFDP1(2), TFDP2(3), TNXB(12), TP53(117), WEE1(2)	44283232	280	192	242	26	12	39	19	102	106	2	2.12e-09	3.77e-09	8.02e-08
30	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(2), NFYB(1), NFYC(2), RB1(24), SP1(2), SP3(3)	3786855	34	31	33	2	0	1	2	9	21	1	0.0766	8.04e-09	1.65e-07
31	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDKN1B(5), CKS1B(2), CUL1(2), E2F1(3), RB1(24), SKP2(1), TFDP1(2)	4855410	40	35	38	2	0	1	3	10	25	1	0.0177	2.97e-07	5.90e-06
32	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(3), CCNE1(1), CDC34(1), CUL1(2), E2F1(3), RB1(24), SKP2(1), TFDP1(2)	4913473	37	32	36	2	0	2	3	10	21	1	0.0355	4.31e-06	8.30e-05
33	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(1), CUL1(2), E2F1(3), FBXW7(3), RB1(24), TFDP1(2)	4790375	36	31	35	3	0	2	3	10	20	1	0.0887	4.46e-05	0.000833
34	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCND1(1), CCNE1(1), CDK6(1), CDKN1A(6), CDKN1B(5), E2F1(3), MAPK1(3), NFKB1(3), NFKBIA(2), PAK1(3), PIK3CA(13), PIK3R1(4), RAF1(2), RB1(24), RELA(4), TFDP1(2)	11467067	79	63	72	8	1	9	6	30	32	1	0.00785	8.08e-05	0.00146
35	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNA2(4), CCND1(1), CCNE1(1), CCNE2(2), CDKN1B(5), CDKN2A(11), E2F1(3), E2F4(2)	5099075	32	30	29	1	0	5	2	17	8	0	0.00560	0.000139	0.00245
36	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(3), CDKN1B(5), MAPK1(3), PDK2(1), PDPK1(1), PIK3CA(13), PIK3R1(4), PTEN(11), PTK2(9), SHC1(3), SOS1(8)	11139372	63	48	57	2	3	12	10	16	21	1	1.28e-05	0.000210	0.00360
37	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTG1(1), ARHGEF2(5), ARPC5L(1), CDC42(3), CDH1(7), CLDN1(1), CTNNB1(102), CTTN(3), EZR(1), FYN(1), HCLS1(2), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(1), ROCK1(6), ROCK2(3), TLR4(5), TLR5(1), TUBA1A(1), TUBA3C(2), TUBA3D(2), TUBA3E(4), TUBA4A(3), TUBA8(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(2), WASL(2), YWHAZ(1)	29549719	187	141	110	23	5	42	27	88	25	0	1.01e-05	0.000349	0.00566
38	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTG1(1), ARHGEF2(5), ARPC5L(1), CDC42(3), CDH1(7), CLDN1(1), CTNNB1(102), CTTN(3), EZR(1), FYN(1), HCLS1(2), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(1), ROCK1(6), ROCK2(3), TLR4(5), TLR5(1), TUBA1A(1), TUBA3C(2), TUBA3D(2), TUBA3E(4), TUBA4A(3), TUBA8(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(2), WASL(2), YWHAZ(1)	29549719	187	141	110	23	5	42	27	88	25	0	1.01e-05	0.000349	0.00566
39	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(7)	395753	7	7	7	0	1	2	0	4	0	0	0.187	0.000579	0.00914
40	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(2), ATM(9), BUB1(2), BUB1B(2), CCNA1(3), CCNA2(4), CCNB1(2), CCNB2(1), CCNB3(4), CCND2(3), CCNE1(1), CCNE2(2), CCNH(1), CDAN1(4), CDC14A(1), CDC14B(3), CDC25B(2), CDC25C(3), CDC7(5), CDH1(7), CDKN1A(6), CDKN2A(11), CHEK1(5), CHEK2(5), DTX4(2), E2F1(3), E2F3(2), E2F4(2), E2F6(2), EP300(11), ESPL1(2), GSK3B(3), HDAC2(3), HDAC4(7), HDAC5(4), HDAC6(7), HDAC8(1), MAD1L1(2), MAD2L1(1), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), MDM2(1), MPEG1(4), MPL(1), PLK1(2), PRKDC(6), PTPRA(4), PTTG1(3), RB1(24), RBL1(4), SKP2(1), SMAD4(5), TBC1D8(3), TFDP1(2), TGFB1(1), TP53(117), WEE1(2)	63300408	343	204	304	32	20	46	25	127	123	2	2.06e-10	0.00130	0.0200
41	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(6), GREB1(12), HSPB1(1), HSPB2(1), MTA1(6), PDZK1(4), TUBA8(2)	6506963	33	32	31	2	3	13	6	7	4	0	0.000993	0.00231	0.0347
42	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(13), PIK3R1(4), PLCB1(8), PLCG1(7), PRKCA(1), VAV1(3)	7243285	38	34	32	2	1	10	4	12	11	0	0.00382	0.00325	0.0477
43	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	APAF1(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), BNIP3L(1), CASP10(2), CASP3(3), CASP4(3), CASP6(2), CASP8(1), CASP9(1), CHUK(8), DFFB(1), FADD(1), FAS(3), GZMB(2), HELLS(5), IKBKB(4), IRF1(1), IRF2(5), IRF3(1), IRF4(2), IRF5(1), IRF6(1), IRF7(1), JUN(2), MAP2K4(4), MAP3K1(3), MAPK10(3), MDM2(1), MYC(2), NFKB1(3), NFKBIA(2), PLEKHG5(2), PRF1(4), RELA(4), RIPK1(4), TNF(1), TNFRSF10B(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(2), TNFSF10(1), TP53(117), TP73(2), TRAF1(1), TRAF3(1)	33260390	234	170	201	30	17	46	19	67	85	0	2.00e-05	0.00374	0.0535
44	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(1), MAP2K2(2), MAP2K3(2), MAP2K6(2), MAP3K1(3), MAPK1(3), MAPK14(3), NFKB1(3), PIK3CA(13), PIK3R1(4), RB1(24), RELA(4), SP1(2)	11105145	68	54	62	8	2	9	8	19	29	1	0.0241	0.00418	0.0585
45	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(3), AKT3(2), BPNT1(2), MAPK1(3), PDK1(1), PIK3CA(13), PIK3CD(5), PTEN(11), PTK2B(5), RBL2(11), SHC1(3), SOS1(8)	11387914	69	58	64	7	4	16	11	17	20	1	0.00339	0.00430	0.0588
46	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(3), CFL1(1), GNAQ(1), GNAS(10), GNB1(2), LIMK1(4), MAPK1(3), NOX1(3), PIK3C2G(7), PLCB1(8), PPP1R12B(4), PRKCA(1), PTK2(9), RAF1(2), ROCK2(3)	14537713	62	52	59	2	7	16	7	22	10	0	2.34e-05	0.00982	0.129
47	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(3), LPO(4), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), TPO(13), TYR(5)	5528691	34	31	34	3	2	6	8	11	7	0	0.00756	0.00984	0.129
48	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), NTRK1(5), PIK3CA(13), PIK3R1(4), PLCG1(7), PRKCA(1), SHC1(3), SOS1(8)	8812761	43	37	37	3	4	9	8	10	11	1	0.00231	0.0110	0.142
49	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(1), BAX(3), CAD(4), CASP10(2), CASP3(3), CASP8(1), CD7(1), CSNK1A1(2), DAXX(1), DEDD2(3), DIABLO(1), EGFR(6), EPHB2(4), FADD(1), FAF1(2), FAIM2(1), HSPB1(1), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAP3K5(1), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MET(2), NFAT5(6), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), NR0B2(4), PTPN13(14), RALBP1(1), RIPK1(4), ROCK1(6), SMPD1(4), TNFRSF6B(1), TP53(117), TPX2(3)	42715526	230	162	195	29	13	41	18	74	84	0	5.48e-05	0.0132	0.166
50	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), ATP6V0C(2), CAT(1), EPX(3), LPO(4), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), SHMT1(2), SHMT2(4), TPO(13)	6710725	40	34	40	3	2	9	6	11	12	0	0.00588	0.0169	0.208
51	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(3), AKT3(2), CDKN1A(6), MAP2K2(2), NGFR(3), NTRK1(5), PIK3CA(13), PIK3CD(5), SHC1(3), SOS1(8)	9479510	52	47	47	6	5	13	9	15	9	1	0.00785	0.0197	0.238
52	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(1), GNB1(2), HTR2C(3), PLCB1(8), TUB(3)	3981712	20	18	20	1	1	3	2	6	8	0	0.0640	0.0270	0.319
53	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), PTK2B(5), SHC1(3), SOS1(8), SRC(3)	4901533	20	20	20	1	2	6	4	4	3	1	0.0183	0.0302	0.351
54	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), IGF1R(11), IRS1(3), MAPK1(3), PIK3CA(13), PIK3R1(4), RAF1(2), SHC1(3), SOS1(8)	10552347	49	42	44	3	4	9	11	15	9	1	0.000446	0.0313	0.357
55	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA3(1), PSMA4(2), PSMA5(3), PSMA7(3), PSMB1(1), PSMB10(2), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(1), PSMB9(1)	4919552	23	21	23	1	0	7	4	8	4	0	0.0137	0.0372	0.412
56	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IFNG(3), IL12A(6), IL12B(2), IL18(2)	1718224	13	12	13	2	0	1	3	7	2	0	0.339	0.0375	0.412
57	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(3), AKT3(2), BCR(2), CD19(2), CDKN2A(11), DAPP1(1), FLOT1(3), GAB1(3), ITPR1(15), ITPR2(11), ITPR3(11), LYN(1), NR0B2(4), PDK1(1), PHF11(3), PIK3CA(13), PITX2(1), PLCG2(7), PPP1R13B(4), PREX1(16), PTEN(11), PTPRC(8), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), RPS6KB1(2), SAG(2), SYK(1), VAV1(3)	31404723	164	118	156	16	15	30	18	65	36	0	4.01e-06	0.0381	0.412
58	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(11), PDXK(1), PNPO(1), PSAT1(2)	2699768	15	13	15	1	0	8	1	3	3	0	0.0723	0.0463	0.492
59	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(1), EPX(3), LPO(4), MPO(5), MTHFR(1), PRDX6(1), SHMT1(2), SHMT2(4), TPO(13)	6517697	36	30	36	3	2	9	7	9	9	0	0.00661	0.0497	0.519
60	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(2), FOS(1), JUN(2), MAPK8(1), NGFR(3), PIK3CA(13), PIK3R1(4), PLCG1(7), RAF1(2), SHC1(3), SOS1(8)	10782529	46	40	40	3	3	9	8	13	12	1	0.00150	0.0524	0.538
61	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3G(1), CD80(4), CD86(2), CTLA4(1), HLA-DRA(1), HLA-DRB1(1), ITK(1), LCK(4), PIK3CA(13), PIK3R1(4), PTPN11(4)	7132317	36	32	31	4	1	9	4	16	6	0	0.0362	0.0623	0.629
62	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), NR0B2(4), NR1H3(4), NR1H4(5), RXRA(2)	2992040	17	15	16	1	1	0	5	8	3	0	0.0567	0.0732	0.727
63	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(6), ACO2(3), FH(3), IDH1(8), IDH2(4), MDH1(1), SDHB(1), SUCLA2(2)	5028382	28	25	25	4	4	4	3	11	6	0	0.163	0.0753	0.737
64	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(2), FOS(1), IGF1R(11), IRS1(3), JUN(2), MAPK8(1), PIK3CA(13), PIK3R1(4), PTPN11(4), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SRF(1)	13954289	65	53	60	7	4	13	12	19	16	1	0.00255	0.0901	0.867
65	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), CHRNB1(2), CHRNG(1), MUSK(6), PIK3CA(13), PIK3R1(4), PTK2(9), PTK2B(5), SRC(3), TERT(2)	9564099	47	40	42	5	1	16	6	15	9	0	0.00769	0.0958	0.908
66	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(3), CYP11A1(1), CYP11B1(4), CYP11B2(5), CYP17A1(3), HSD11B1(2), HSD3B1(2)	5118543	21	20	21	2	5	4	2	7	3	0	0.0533	0.106	0.973
67	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(3), CYP11A1(1), CYP11B1(4), CYP11B2(5), CYP17A1(3), HSD11B1(2), HSD3B1(2)	5118543	21	20	21	2	5	4	2	7	3	0	0.0533	0.106	0.973
68	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(2), FOS(1), IL6(2), IL6R(3), IL6ST(12), JAK1(13), JAK2(4), JAK3(7), JUN(2), PTPN11(4), RAF1(2), SHC1(3), SOS1(8), SRF(1), STAT3(4)	13713379	68	53	65	7	5	13	10	22	17	1	0.00561	0.107	0.973
69	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(4), SNAP25(3), STX1A(1)	1758176	11	11	10	2	1	3	1	4	2	0	0.486	0.111	0.987
70	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(3), LPO(4), MPO(5), PRDX6(1), TPO(13)	4778378	26	23	26	3	2	5	6	8	5	0	0.0286	0.113	0.991
71	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(9), JUND(1), PPP1R1B(1)	2130336	12	12	11	3	2	1	4	4	1	0	0.345	0.115	0.994
72	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(3), AKT1(2), AKT2(3), AKT3(2), CDKN2A(11), DAPP1(1), GSK3A(1), GSK3B(3), IARS(5), PDK1(1), PIK3CA(13), PPP1R13B(4), PTEN(11), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), RPS6KB1(2), SHC1(3), SOS1(8), SOS2(4), YWHAE(1), YWHAZ(1)	20208775	100	75	93	11	8	19	13	29	30	1	0.000926	0.125	1.000
73	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(1), GLUD1(3), GLUD2(5)	2564143	13	12	13	1	0	5	4	2	2	0	0.0781	0.126	1.000
74	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(3), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(1), IL5(1), IL5RA(1), IL6(2)	2949224	13	12	13	1	1	0	1	10	1	0	0.186	0.129	1.000
75	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(1), COQ5(1), COQ6(4), COQ7(1)	2441218	9	9	9	1	1	1	2	3	2	0	0.285	0.169	1.000
76	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(3), AKT3(2), CAB39(2), DDIT4(1), EIF4B(1), FIGF(1), HIF1A(3), INS(1), MAPK1(3), PDPK1(1), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PRKAA1(4), RHEB(1), RICTOR(8), RPS6(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), RPS6KA6(8), RPS6KB1(2), RPS6KB2(4), STK11(1), TSC1(8), TSC2(12), ULK1(3), ULK2(5), ULK3(1), VEGFA(1), VEGFC(6)	30805451	144	99	134	10	8	34	16	40	46	0	4.87e-08	0.170	1.000
77	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(2), CDKN1A(6), CHEK1(5), NEK1(1), WEE1(2)	4333248	16	16	16	1	1	1	2	5	7	0	0.160	0.172	1.000
78	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(2), BCL2(1), CBL(4), CFLAR(2), E2F1(3), FOS(1), IL2RA(1), IL2RB(2), IL2RG(1), IRS1(3), JAK1(13), JAK3(7), MAPK1(3), MYC(2), NMI(2), PIK3CA(13), PIK3R1(4), PTPN6(2), RAF1(2), RPS6KB1(2), SHC1(3), SOCS3(1), SOS1(8), STAT5A(2), STAT5B(1), SYK(1)	20501629	86	73	78	9	9	15	15	31	15	1	0.000354	0.174	1.000
79	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	GSTZ1(2), HGD(4)	1238975	6	6	6	0	0	1	0	4	1	0	0.364	0.175	1.000
80	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(2), FOS(1), INS(1), INSR(4), IRS1(3), JUN(2), MAPK8(1), PIK3CA(13), PIK3R1(4), PTPN11(4), RAF1(2), RASA1(10), SHC1(3), SLC2A4(2), SOS1(8), SRF(1)	14376789	61	52	56	7	4	12	12	17	15	1	0.00345	0.180	1.000
81	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(2)	280438	2	2	2	0	0	0	0	1	1	0	0.858	0.188	1.000
82	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(7), PRKCA(1), PTK2B(5)	3741191	14	14	13	1	0	5	0	4	5	0	0.259	0.191	1.000
83	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3)	6067489	28	25	26	3	2	3	3	13	7	0	0.0429	0.219	1.000
84	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(3), CASP8(1), CFL1(1), CFLAR(2)	2141634	8	7	8	1	0	2	1	2	3	0	0.390	0.220	1.000
85	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(4), FH(3), IDH2(4), MDH1(1), OGDH(1), SDHA(2), SUCLA2(2)	5334258	20	18	20	2	1	4	2	6	7	0	0.115	0.223	1.000
86	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL2RG(1), IL4(1), IL4R(1), IRS1(3), JAK1(13), JAK3(7), RPS6KB1(2), SHC1(3), STAT6(5)	8323562	38	33	35	3	5	6	4	14	9	0	0.0163	0.227	1.000
87	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	AIFM1(3), AKT1(2), AKT2(3), AKT3(2), APAF1(9), ATM(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), CAPN1(2), CAPN2(1), CASP10(2), CASP3(3), CASP6(2), CASP8(1), CASP9(1), CFLAR(2), CHUK(8), CSF2RB(2), DFFB(1), FADD(1), FAS(3), IKBKB(4), IL1B(1), IL1R1(4), IL1RAP(1), IRAK1(5), IRAK3(3), IRAK4(4), MYD88(1), NFKB1(3), NFKB2(2), NFKBIA(2), NTRK1(5), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PPP3CA(3), PPP3CB(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RELA(4), RIPK1(4), TNF(1), TNFRSF10B(2), TNFRSF10D(2), TNFRSF1A(1), TNFSF10(1), TP53(117)	48096342	286	184	247	34	19	75	22	77	93	0	1.72e-07	0.232	1.000
88	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), CD80(4), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL4(1)	2204585	9	9	9	2	0	2	1	5	1	0	0.480	0.260	1.000
89	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(12), AXIN1(25), CCND1(1), CCND2(3), CSNK1E(3), CTNNB1(102), DVL1(3), DVL2(6), DVL3(1), FBXW2(3), FZD1(2), FZD10(1), FZD2(4), FZD3(2), FZD6(2), FZD7(3), FZD8(2), FZD9(3), GSK3B(3), JUN(2), LDLR(2), MAPK10(3), MAPK9(3), MYC(2), PAFAH1B1(1), PPP2R5C(3), PPP2R5E(1), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), TCF7(2), WNT1(2), WNT11(1), WNT2(3), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1)	33046042	234	160	156	32	10	52	27	94	50	1	8.98e-06	0.289	1.000
90	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(2), ANAPC1(4), ANAPC11(1), ANAPC2(5), ANAPC4(1), ANAPC5(1), ANAPC7(4), ATM(9), ATR(15), BUB1(2), BUB1B(2), CCNA1(3), CCNA2(4), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(1), CCND2(3), CCNE1(1), CCNE2(2), CCNH(1), CDC14A(1), CDC14B(3), CDC16(1), CDC23(1), CDC25B(2), CDC25C(3), CDC27(15), CDC7(5), CDK6(1), CDKN1A(6), CDKN1B(5), CDKN1C(2), CDKN2A(11), CDKN2B(1), CDKN2C(2), CHEK1(5), CHEK2(5), CREBBP(6), CUL1(2), E2F1(3), E2F3(2), EP300(11), ESPL1(2), FZR1(6), GADD45G(1), GSK3B(3), HDAC2(3), MAD1L1(2), MAD2L1(1), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), MDM2(1), PKMYT1(1), PLK1(2), PRKDC(6), PTTG1(3), RB1(24), RBL1(4), RBL2(11), SKP2(1), SMAD2(1), SMAD3(3), SMAD4(5), SMC1A(5), SMC1B(3), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(2), TP53(117), WEE1(2), YWHAE(1), YWHAZ(1)	77943108	402	216	356	42	22	60	26	144	148	2	1.23e-09	0.293	1.000
91	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(2), CAT(1), GH1(1), GHR(3), IGF1R(11), PIK3CA(13), PIK3R1(4), SHC1(3)	7413704	38	32	33	5	4	7	6	12	9	0	0.0304	0.303	1.000
92	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(3), HLA-DRA(1), HLA-DRB1(1), IL5(1)	1633362	7	7	7	0	1	0	0	6	0	0	0.214	0.313	1.000
93	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(6), CAPN1(2), CAPNS1(1), CSNK1A1(2), GSK3B(3), MAPT(6), PPP2CA(2)	5532449	22	21	22	1	1	8	0	6	7	0	0.0335	0.320	1.000
94	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(2), CBS(3), CTH(2), MUT(4)	2794156	11	10	11	1	1	4	0	2	4	0	0.257	0.331	1.000
95	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(1), NR3C1(3), PPARG(1), RXRA(2), TNF(1)	3219049	10	10	9	1	0	0	2	5	3	0	0.381	0.332	1.000
96	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA3(1), PSMA4(2), PSMA5(3), PSMA7(3), PSMB1(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(2), PSMD1(7), PSMD11(1), PSMD12(7), PSMD13(2), PSMD2(2), PSMD6(1)	9003610	42	35	42	5	1	14	5	15	7	0	0.0163	0.343	1.000
97	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(1), CPS1(12), GLS(4), GLUD1(3)	4373737	21	18	21	4	1	8	3	4	5	0	0.232	0.346	1.000
98	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(3), AKT1(2), ANXA1(1), GNAS(10), GNB1(2), NFKB1(3), NOS3(9), NR3C1(3), PIK3CA(13), PIK3R1(4), RELA(4), SYT1(2)	10382056	56	49	47	9	8	12	6	19	11	0	0.0848	0.357	1.000
99	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(5), ERBB4(11), NRG2(1), NRG3(3), PRKCA(1), PSEN1(2)	5099442	23	22	22	4	1	4	1	14	3	0	0.318	0.363	1.000
100	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CXCL12(1), CXCR4(2), GNAI1(4), GNAQ(1), GNB1(2), MAPK1(3), NFKB1(3), PIK3C2G(7), PIK3CA(13), PIK3R1(4), PLCG1(7), PRKCA(1), PTK2(9), PTK2B(5), PXN(2), RAF1(2), RELA(4)	15946228	73	60	67	9	1	22	7	27	16	0	0.00795	0.394	1.000
101	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(2), GGT1(1), SHMT1(2), SHMT2(4)	2446983	9	9	9	0	1	4	0	2	2	0	0.0923	0.400	1.000
102	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP11B2(5), CYP17A1(3), HSD11B1(2), HSD3B1(2)	3872882	14	13	14	2	4	2	1	4	3	0	0.195	0.402	1.000
103	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(9), ARHGAP5(3), CASP10(2), CASP3(3), CASP8(1), CASP9(1), GZMB(2), JUN(2), PRF1(4)	7106840	27	23	27	2	1	10	2	7	7	0	0.0410	0.406	1.000
104	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), FOS(1), JAK1(13), JUN(2), MAP2K4(4), MAP3K1(3), MAPK8(1), PDGFA(2), PDGFRA(5), PIK3CA(13), PIK3R1(4), PLCG1(7), PRKCA(1), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SRF(1), STAT1(5), STAT3(4), STAT5A(2)	19786496	93	72	84	11	3	19	12	32	26	1	0.00447	0.416	1.000
105	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(5), AKT1(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CREB1(1), GNAS(10), MAPK1(3), MAPK14(3), PIK3CA(13), PIK3R1(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), RPS6KA1(1), RPS6KA5(5), SOS1(8)	16752459	75	57	66	8	11	18	10	19	16	1	0.00129	0.418	1.000
106	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), DOCK1(7), FOS(1), GAB1(3), HGF(7), ITGA1(5), JUN(2), MAP2K2(2), MAP4K1(1), MAPK1(3), MAPK8(1), MET(2), PAK1(3), PIK3CA(13), PIK3R1(4), PTEN(11), PTK2(9), PTK2B(5), PTPN11(4), PXN(2), RAF1(2), RAP1A(2), RASA1(10), SOS1(8), SRC(3), STAT3(4)	25705492	115	82	109	12	4	31	14	38	27	1	8.68e-05	0.420	1.000
107	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB1A(2), RAB27A(1), RAB4A(2), RAB6A(2), RAB9A(1)	2410361	9	8	9	1	0	3	1	2	3	0	0.400	0.436	1.000
108	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A2(3), EIF4B(1), EIF4G1(7), EIF4G2(4), EIF4G3(6), MKNK1(2), PDK2(1), PDPK1(1), PIK3CA(13), PIK3R1(4), PPP2CA(2), PTEN(11), RPS6(2), RPS6KB1(2), TSC1(8), TSC2(12)	15864788	81	62	73	10	2	16	11	18	33	1	0.00660	0.441	1.000
109	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(2), IL6(2), LDLR(2), LPL(1)	2959650	9	9	9	1	1	1	1	5	1	0	0.293	0.460	1.000
110	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(1), MAPK1(3), MAPK7(3), MEF2A(6), MEF2C(1), MEF2D(3), NTRK1(5), PIK3CA(13), PIK3R1(4), PLCG1(7), RPS6KA1(1), SHC1(3)	11258574	52	45	46	7	4	11	6	19	12	0	0.0371	0.476	1.000
111	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(10), GNB1(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1)	5670295	23	21	20	3	6	6	2	4	5	0	0.157	0.479	1.000
112	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(5), GABRA2(7), GABRA3(1), GABRA4(6), GABRA5(4), GABRA6(7)	3673000	30	26	27	8	0	5	1	15	9	0	0.718	0.485	1.000
113	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(2), HDAC9(8), MEF2A(6), MEF2C(1), MEF2D(3), MYOD1(1)	4925385	22	21	22	4	0	4	2	13	3	0	0.268	0.490	1.000
114	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCL2(1), BCR(2), FOS(1), JAK2(4), JUN(2), MAP2K4(4), MAP3K1(3), MAPK8(1), MYC(2), PIK3CA(13), PIK3R1(4), RAF1(2), SOS1(8), STAT1(5), STAT5A(2), STAT5B(1)	15646595	57	49	52	6	3	11	9	18	15	1	0.00799	0.511	1.000
115	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(1), AGTR1(2), BDKRB2(3), KNG1(3), NOS3(9)	5740674	22	20	21	3	2	6	2	7	5	0	0.129	0.541	1.000
116	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(10), HADHA(3), SDS(2)	2746271	17	9	17	4	0	3	4	6	4	0	0.454	0.554	1.000
117	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(1), EIF2S2(1), EIF2S3(1), GSK3B(3), IGF1R(11), INPPL1(1), PDK2(1), PDPK1(1), PIK3CA(13), PIK3R1(4), PPP2CA(2), PTEN(11), RPS6(2), RPS6KB1(2)	11456854	56	45	50	8	2	10	6	18	20	0	0.0539	0.559	1.000
118	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(3)	1120947	3	3	3	0	0	2	0	1	0	0	0.415	0.560	1.000
119	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(1), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2D3(4), UBE2E1(1), UBE2J1(3), UBE2J2(2), UBE2L3(1), UBE2N(4), UBE3A(1)	5920459	21	18	21	2	0	4	4	6	7	0	0.112	0.570	1.000
120	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(1), GLS(4), GLUD1(3), OAT(2), PRODH(1)	3381489	12	10	12	0	0	5	2	2	3	0	0.0467	0.572	1.000
121	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(9), BCL2(1), CASP3(3), CASP9(1), DAXX(1), FAS(3), HSPB1(1), HSPB2(1), MAPKAPK2(1), MAPKAPK3(1), TNF(1)	6278515	24	22	24	4	0	13	2	4	5	0	0.139	0.575	1.000
122	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(3), CD36(3), FOS(1), FYN(1), JUN(2), MAPK14(3), THBS1(6)	3989581	19	18	19	4	3	1	4	7	4	0	0.376	0.583	1.000
123	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(7), DYRK1B(2), GLI2(12), GLI3(11), GSK3B(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), SHH(1), SMO(1), SUFU(3)	9592315	48	43	47	8	7	8	1	18	14	0	0.0793	0.597	1.000
124	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(1)	1007741	2	2	2	0	0	1	0	0	1	0	0.717	0.598	1.000
125	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(2), BLNK(3), FOS(1), JUN(2), LYN(1), MAP3K1(3), MAPK1(3), MAPK8IP3(2), PAPPA(5), RPS6KA1(1), RPS6KA3(15), SHC1(3), SOS1(8), SYK(1), VAV1(3), VAV3(8)	18217381	62	56	61	6	4	16	9	22	10	1	0.00113	0.598	1.000
126	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP2E1(4), NR1I3(2), PTGS1(2), PTGS2(3)	2927653	11	11	11	3	2	2	0	4	3	0	0.694	0.611	1.000
127	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(3), NFKBIA(2), PLCB1(8), PRKCA(1), RELA(4)	4678537	19	18	19	4	0	5	2	7	5	0	0.455	0.616	1.000
128	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFA5(2), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFB7(2), NDUFS1(2), NDUFS2(2), NDUFV2(2)	3999223	14	14	14	2	0	3	2	9	0	0	0.219	0.620	1.000
129	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3G(1), GZMB(2), HLA-A(3), ICAM1(1), ITGAL(5), ITGB2(8), PRF1(4)	4813374	25	22	24	4	2	8	0	9	6	0	0.281	0.622	1.000
130	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRA(1), HLA-DRB1(1)	1312979	3	3	3	1	0	0	0	3	0	0	0.860	0.626	1.000
131	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(5), ARHGEF1(1), F2(2), F2R(1), F2RL3(1), GNA12(1), GNA13(1), GNAI1(4), GNAQ(1), GNB1(2), MAP3K7(3), PIK3CA(13), PIK3R1(4), PLCB1(8), PPP1R12B(4), PRKCA(1), PTK2B(5), ROCK1(6)	14556063	63	53	58	9	1	17	7	21	17	0	0.0251	0.632	1.000
132	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(2), SPCS3(2)	1757643	7	5	7	2	0	2	2	2	1	0	0.640	0.632	1.000
133	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(2), IFNG(3), IL10(1), IL12A(6), IL12B(2), IL16(7), IL18(2), IL4(1), IL5(1), IL6(2), TNF(1)	5551349	28	26	27	6	0	5	6	14	3	0	0.237	0.642	1.000
134	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(4), ACTN2(6), BCAR1(3), BCR(2), CAPN1(2), CAPNS1(1), CAV1(1), CSK(1), FYN(1), ITGA1(5), JUN(2), MAP2K2(2), MAPK1(3), MAPK8(1), PPP1R12B(4), PTK2(9), PXN(2), RAF1(2), RAP1A(2), ROCK1(6), SHC1(3), SOS1(8), SRC(3), TLN1(10), VCL(3), ZYX(2)	26968140	89	65	89	3	6	26	13	24	19	1	8.17e-08	0.654	1.000
135	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(1)	934726	2	2	2	0	0	0	0	1	1	0	0.564	0.680	1.000
136	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), CRY1(1), CRY2(1), CSNK1E(3), PER1(6)	4818668	12	11	12	2	0	5	1	5	0	1	0.355	0.682	1.000
137	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), GNAQ(1), JUN(2), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP3K1(3), MAPK1(3), MAPK14(3), MAPK8(1), PAK1(3), PLCG1(7), PRKCA(1), PTK2B(5), RAF1(2), SHC1(3), SOS1(8), SRC(3), SYT1(2)	16100120	58	52	57	6	3	12	7	20	15	1	0.0135	0.682	1.000
138	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(2), EPX(3), HPD(2), LPO(4), MAOA(1), MAOB(8), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), TAT(3), TPO(13)	12507820	52	44	52	5	3	11	7	16	15	0	0.00551	0.682	1.000
139	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), DIAPH1(5), FYN(1), GSN(2), ITGA1(5), MAPK1(3), MYLK(3), PIK3CA(13), PIK3R1(4), PTK2(9), PXN(2), RAF1(2), ROCK1(6), SHC1(3), SRC(3), TLN1(10)	21247149	74	60	69	6	4	17	8	27	18	0	0.000217	0.701	1.000
140	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDPS(2), HMGCR(6), IDI1(1), LSS(5), MVD(3), MVK(2), NQO1(2), PMVK(3), SQLE(1)	6311359	26	21	26	4	2	6	5	8	4	1	0.134	0.705	1.000
141	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDPS(2), HMGCR(6), HMGCS1(2), IDI1(1), LSS(5), MVD(3), MVK(2), NSDHL(1), PMVK(3), SQLE(1)	7496642	27	22	27	4	2	7	5	7	5	1	0.121	0.714	1.000
142	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(4), FUT9(4), GCNT2(1)	3499754	10	9	10	1	1	0	1	7	1	0	0.232	0.728	1.000
143	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(13), JAK2(4), JAK3(7), MAPK1(3), STAT3(4), TYK2(1)	6839453	32	29	29	5	4	5	4	14	5	0	0.139	0.733	1.000
144	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS1(1), DHRS3(1), DHRS7(1), HEMK1(3), LCMT2(3), METTL2B(5), METTL6(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), WBSCR22(2)	8364562	30	29	30	5	5	7	4	10	3	1	0.134	0.734	1.000
145	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), TAT(3), TYR(5)	2615122	10	10	10	3	0	2	2	3	3	0	0.619	0.741	1.000
146	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1)	7596124	21	18	21	1	1	5	2	7	6	0	0.0324	0.748	1.000
147	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), FMOD(1), KERA(1), LUM(5)	1999539	9	9	9	3	0	3	0	4	2	0	0.776	0.753	1.000
148	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GGT1(1), SHMT1(2), SHMT2(4)	3246244	8	8	8	1	1	4	1	1	1	0	0.220	0.755	1.000
149	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(10), GNB1(2), PRKACA(2)	3834275	19	18	16	4	6	4	1	6	2	0	0.451	0.758	1.000
150	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA3(1), PSMA4(2), PSMA5(3), PSMA7(3), PSMB1(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(1), PSMD14(1), RPN1(1), RPN2(2), UBE3A(1)	7449521	25	22	25	3	0	10	3	8	4	0	0.0742	0.787	1.000
151	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25B(2), CDC25C(3), CSK(1), PRKCA(1), PTPRA(4), SRC(3)	5258311	16	16	16	3	0	2	2	7	5	0	0.385	0.791	1.000
152	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(5), ACYP1(1), ECHS1(2), EHHADH(10), GCDH(1), HADHA(3), SDHB(1), SDS(2)	4383370	27	18	27	7	0	5	6	9	7	0	0.472	0.799	1.000
153	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), CDC42(3), PAK1(3), PDGFRA(5), PIK3CA(13), PIK3R1(4), WASL(2)	7560383	38	34	33	7	3	11	8	10	6	0	0.0958	0.800	1.000
154	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1), SLPI(1)	922839	2	2	2	2	0	0	1	0	1	0	0.962	0.801	1.000
155	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(3), AKT3(2), CISH(5), IARS(5), IL13RA1(2), IL2RG(1), IL4(1), IL4R(1), JAK1(13), JAK2(4), JAK3(7), NR0B2(4), PIK3CA(13), PPP1R13B(4), RPS6KB1(2), SERPINA4(2), SHC1(3), SOS1(8), SOS2(4), SRC(3), STAT6(5), TYK2(1)	20800637	95	71	87	12	10	24	13	30	17	1	0.00117	0.804	1.000
156	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), CPOX(1), FECH(1), HMBS(4), PPOX(3)	4427944	12	12	12	2	1	1	1	2	7	0	0.384	0.805	1.000
157	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2R(1), F2RL3(1), GNAI1(4), GNB1(2), ITGA1(5), MAPK1(3), PLA2G4A(8), PLCB1(8), PRKCA(1), PTGS1(2), PTK2(9), RAF1(2), SRC(3), SYK(1)	13732862	52	46	52	7	1	18	5	17	11	0	0.0165	0.809	1.000
158	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(3)	1466952	3	3	3	2	0	1	0	0	2	0	0.946	0.813	1.000
159	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2)	3124428	12	12	12	3	0	1	2	4	5	0	0.687	0.821	1.000
160	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), CASP9(1), CHUK(8), GH1(1), GHR(3), NFKB1(3), NFKBIA(2), PDPK1(1), PIK3CA(13), PIK3R1(4), PPP2CA(2), RELA(4)	8278187	44	37	39	8	2	10	7	14	11	0	0.151	0.824	1.000
161	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(3), IL18(2), KLRC1(1), KLRC3(2), KLRC4(1), LAT(1), PAK1(3), PIK3CA(13), PIK3R1(4), PTK2B(5), PTPN6(2), SYK(1), VAV1(3)	10666864	42	38	37	7	2	8	5	16	11	0	0.128	0.826	1.000
162	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(5), IL6(2), IL6R(3), JAK1(13), JAK2(4), JAK3(7), PIAS3(1), PTPRU(2), REG1A(1), SRC(3), STAT3(4)	8779835	45	38	42	8	3	10	5	19	8	0	0.155	0.826	1.000
163	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(2), AKT2(3), AKT3(2), BRD4(6), CBL(4), CDC42(3), CDKN2A(11), FLOT1(3), GSK3A(1), GSK3B(3), INPPL1(1), IRS1(3), IRS2(2), IRS4(7), LNPEP(6), MAPK1(3), PARD3(3), PDK1(1), PIK3CA(13), PIK3CD(5), PIK3R1(4), PTEN(11), RAF1(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), RPS6KB1(2), SERPINB6(2), SHC1(3), SLC2A4(2), SORBS1(1), SOS1(8), SOS2(4), YWHAE(1), YWHAZ(1)	33358302	144	109	137	19	11	26	22	43	41	1	0.000182	0.830	1.000
164	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(11), RANGAP1(2)	4604493	14	13	13	3	1	3	3	5	2	0	0.326	0.830	1.000
165	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), EGF(6), EGFR(6), FOS(1), JAK1(13), JUN(2), MAP2K4(4), MAP3K1(3), MAPK8(1), PIK3CA(13), PIK3R1(4), PLCG1(7), PRKCA(1), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SRF(1), STAT1(5), STAT3(4), STAT5A(2)	21177746	98	78	88	14	3	21	12	33	28	1	0.0196	0.833	1.000
166	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3G(1)	647938	1	1	1	0	0	1	0	0	0	0	0.700	0.836	1.000
167	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(9), CR2(9), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(5), ITGB2(8), PTPRC(8)	9529633	46	41	45	9	1	13	8	17	7	0	0.115	0.841	1.000
168	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), FOS(1), IL2RA(1), IL2RB(2), IL2RG(1), JAK1(13), JAK3(7), JUN(2), LCK(4), MAPK8(1), RAF1(2), SHC1(3), SOS1(8), STAT5A(2), STAT5B(1), SYK(1)	13570019	51	42	49	6	5	9	10	18	8	1	0.00944	0.847	1.000
169	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3G(1), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1)	5907583	25	22	24	4	1	11	4	6	3	0	0.128	0.855	1.000
170	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(2)	1201148	2	2	2	1	0	0	0	0	2	0	1.000	0.859	1.000
171	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), JUN(2), MAPK1(3), MYC(2), NFKB1(3), NFKBIA(2), PLCB1(8), PRKCA(1), RAF1(2), RELA(4), TNF(1)	8646820	31	30	31	5	1	8	4	12	6	0	0.149	0.862	1.000
172	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CD8A(1), CSF1(2), IL4(1), IL5(1), IL6(2), IL7(1)	3557060	9	9	9	2	0	2	1	5	1	0	0.552	0.865	1.000
173	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(2), GGPS1(1), IDI1(1), IDI2(1), SQLE(1)	2467083	6	6	6	0	0	1	2	1	2	0	0.230	0.875	1.000
174	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(2), IDI1(1), SQLE(1)	1871733	4	4	4	0	0	1	1	1	1	0	0.366	0.875	1.000
175	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(8), ABCB11(2), ABCB4(5), ABCC1(3), ABCC3(5), GSTP1(2)	8136463	25	24	25	4	1	5	4	10	5	0	0.151	0.877	1.000
176	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(1), IL10(1), IL10RA(3), IL10RB(2), IL6(2), JAK1(13), STAT1(5), STAT3(4), STAT5A(2), TNF(1)	6904245	35	31	32	7	0	9	3	19	4	0	0.322	0.880	1.000
177	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(1), DDX20(3), E2F1(3), E2F4(2), ETS1(2), ETS2(1), ETV3(4), FOS(1), HDAC2(3), HDAC5(4), JUN(2), NCOR2(14), RBL1(4), RBL2(11), SIN3A(3), SIN3B(3)	15429560	63	53	61	9	8	9	10	21	15	0	0.0229	0.887	1.000
178	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3G(1), CD4(1), CD58(1), CD8A(1), IL6(2), KITLG(2)	3551152	8	8	8	2	0	3	1	2	2	0	0.599	0.889	1.000
179	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(2), AKT2(3), AKT3(2), BCL2(1), GSK3A(1), GSK3B(3), IL4R(1), IRS1(3), IRS2(2), JAK1(13), JAK3(7), MAP4K1(1), MAPK1(3), PDK1(1), PIK3CA(13), PIK3CD(5), PIK3R1(4), PPP1R13B(4), RAF1(2), SHC1(3), SOS1(8), SOS2(4), STAT6(5)	20831245	91	71	84	12	12	21	15	23	19	1	0.00100	0.891	1.000
180	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(2), F2R(1), F3(1), F5(7), FGA(12), FGB(3), PROC(2), SERPINC1(2), TFPI(2)	9301489	35	33	34	5	1	9	6	11	8	0	0.0662	0.898	1.000
181	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(4), SDHA(2), SDHB(1)	3652134	7	6	7	0	0	1	1	1	4	0	0.136	0.904	1.000
182	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(6), ACO2(3), ACSS1(2), ACSS2(1), FH(3), IDH1(8), IDH2(4), MDH1(1), SUCLA2(2)	7490724	33	30	30	7	5	4	5	11	8	0	0.322	0.908	1.000
183	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A2(3), EIF4G1(7), EIF4G2(4), EIF4G3(6), GHR(3), IRS1(3), MAPK1(3), MAPK14(3), MKNK1(2), PDK2(1), PDPK1(1), PIK3CA(13), PIK3R1(4), PRKCA(1), PTEN(11), RPS6KB1(2)	15997838	69	51	62	11	3	13	14	14	24	1	0.0522	0.916	1.000
184	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(9), CDC25B(2), CDC25C(3), CHEK1(5), MYT1(2), WEE1(2)	7807729	23	22	23	4	2	2	2	10	7	0	0.340	0.921	1.000
185	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(2), AOC3(1), CES1(3)	3419440	6	6	6	1	1	1	1	2	1	0	0.353	0.923	1.000
186	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(3), INS(1), INSR(4), IRS1(3), JAK2(4), MAPK1(3), PIK3CA(13), PIK3R1(4), PLCG1(7), PRKCA(1), PTPN6(2), RAF1(2), RPS6KA1(1), SHC1(3), SLC2A4(2), SOS1(8), SRF(1), STAT5A(2), STAT5B(1)	18793670	66	55	60	9	7	11	13	19	15	1	0.00711	0.925	1.000
187	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(5), IFNG(3), IFNGR1(3), JAK1(13), JAK2(4), PTPRU(2), REG1A(1), STAT1(5)	6445965	36	31	34	8	0	9	3	15	9	0	0.461	0.928	1.000
188	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(2), MRPS7(1), RPL10A(2), RPL11(3), RPL13(2), RPL18(1), RPL18A(3), RPL19(1), RPL21(1), RPL23A(1), RPL27(1), RPL28(1), RPL3(3), RPL35A(1), RPL36A(1), RPL37(1), RPL8(1), RPL9(1), RPS10(1), RPS13(1), RPS2(1), RPS23(1), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS6(2), RPS7(1), RPS9(1)	12138737	41	34	40	5	5	14	4	10	8	0	0.0367	0.932	1.000
189	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), SHMT1(2)	8520430	30	29	29	5	0	8	2	12	8	0	0.263	0.933	1.000
190	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), SHMT1(2)	8520430	30	29	29	5	0	8	2	12	8	0	0.263	0.933	1.000
191	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), SHMT1(2)	8520430	30	29	29	5	0	8	2	12	8	0	0.263	0.933	1.000
192	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACAT1(2), ECHS1(2), HADHA(3)	3092657	10	8	10	4	0	3	0	3	4	0	0.872	0.933	1.000
193	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASS(5)	2623568	7	7	7	2	0	2	2	1	2	0	0.695	0.934	1.000
194	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA1(1), FUCA2(1), GLB1(3), HEXA(3), HEXB(1), LCT(6), MAN2C1(5), MANBA(1), NEU1(2), NEU2(4), NEU3(2), NEU4(2)	9607867	33	30	32	5	2	9	6	10	6	0	0.0512	0.934	1.000
195	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL2(1), ST6GALNAC2(3)	3150051	6	6	6	1	0	2	1	1	2	0	0.627	0.936	1.000
196	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3G(1), CD4(1), FYN(1), HLA-DRA(1), HLA-DRB1(1), LCK(4), PTPRC(8), ZAP70(3)	5117434	20	17	20	4	0	3	3	11	3	0	0.437	0.936	1.000
197	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(1), CDC25B(2), CDC25C(3), SHH(1), XPO1(5)	4987515	14	13	14	3	0	1	2	7	4	0	0.504	0.940	1.000
198	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(2), PAPSS1(2), PAPSS2(1), SULT1A2(1), SULT1E1(1), SUOX(2)	4723320	9	9	9	1	0	3	3	2	1	0	0.213	0.940	1.000
199	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), FDXR(1), SHMT1(2)	9059599	31	29	30	5	0	9	2	12	8	0	0.225	0.942	1.000
200	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), HEMK1(3), LCMT2(3), METTL2B(5), METTL6(3), PCYT1A(3), PCYT1B(1), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), WBSCR22(2)	7864935	32	30	32	7	4	8	5	9	5	1	0.308	0.943	1.000
201	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), LCT(6), MPI(2), PGM1(1), PYGL(2), PYGM(8), TPI1(1)	7781155	23	22	23	4	2	6	5	7	3	0	0.117	0.944	1.000
202	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(3), CPO(1), FECH(1), GATA1(3), HMBS(4)	4793392	12	12	12	2	1	2	0	2	7	0	0.390	0.946	1.000
203	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(2), FOS(1), JAK2(4), JUN(2), MPL(1), PIK3CA(13), PIK3R1(4), PLCG1(7), PRKCA(1), RAF1(2), RASA1(10), SHC1(3), SOS1(8), STAT1(5), STAT3(4), STAT5A(2), STAT5B(1)	16904367	70	54	63	10	3	16	9	23	18	1	0.0326	0.949	1.000
204	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(5), HMGCL(2), OXCT1(2)	1906981	11	10	10	5	0	2	1	5	3	0	0.874	0.950	1.000
205	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(7), POLR1B(2), POLR1C(1), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(3), POLR3B(2), POLR3H(1), ZNRD1(1)	12986450	35	28	35	1	2	8	2	10	13	0	0.00343	0.951	1.000
206	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(3), MMP2(1), MMP9(3), RECK(3), TIMP1(2), TIMP3(1), TIMP4(3)	4337630	16	15	16	4	1	4	1	7	3	0	0.499	0.953	1.000
207	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(5), JAK1(13), JAK2(4), JAK3(7), PIAS3(1), PTPRU(2), REG1A(1)	7981537	33	29	31	6	3	7	4	12	7	0	0.202	0.955	1.000
208	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	14	BPNT1(2), CHST11(2), CHST12(2), CHST13(3), PAPSS1(2), PAPSS2(1), SULT1A2(1), SULT1E1(1), SUOX(2)	6543804	16	15	16	2	1	3	3	6	3	0	0.191	0.960	1.000
209	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(3), IFNGR1(3), IFNGR2(1), JAK1(13), JAK2(4), STAT1(5)	4590386	29	24	27	7	0	6	2	14	7	0	0.637	0.961	1.000
210	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(13), EPHB1(5), FYN(1), ITGA1(5), L1CAM(7), LYN(1), SELP(1)	8792317	34	32	34	7	5	11	2	10	6	0	0.198	0.961	1.000
211	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(4), IL6(2), KITLG(2), TGFB1(1), TGFB2(4), TGFB3(2)	4872769	16	16	16	4	1	5	3	4	3	0	0.441	0.961	1.000
212	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(9), BAX(3), BCL10(1), BCL2(1), CASP9(1), CES1(3)	6585107	18	16	17	4	2	10	1	2	3	0	0.196	0.962	1.000
213	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(4), ACTN2(6), CAPN1(2), CAPNS1(1), ITGA1(5), ITGB3(5), PTK2(9), PXN(2), SPTAN1(7), SRC(3), TLN1(10)	16342824	55	45	55	7	5	21	3	13	13	0	0.0224	0.962	1.000
214	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(2), PGAP1(3), PIGA(1), PIGB(1), PIGC(2), PIGL(2), PIGM(4), PIGN(6), PIGO(2), PIGQ(3), PIGS(5), PIGV(2), PIGW(3), PIGZ(4)	13978282	42	37	42	5	4	7	3	16	12	0	0.0596	0.963	1.000
215	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(6), ESR2(1), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(8), PLCB2(3), PRL(3), TRH(2)	6309982	28	26	27	6	3	11	1	7	6	0	0.205	0.965	1.000
216	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(3), CTH(2), GGT1(1), MARS(6), MAT1A(4), PAPSS1(2), PAPSS2(1), SCLY(1)	7034688	20	18	20	3	2	6	1	7	4	0	0.239	0.965	1.000
217	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(5), EGF(6), EGFR(6), HGS(4), TF(3), TFRC(2)	7175766	26	26	25	8	0	8	1	5	12	0	0.882	0.966	1.000
218	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(3), AKT3(2), CASP9(1), CDC42(3), KDR(7), KRAS(6), MAP2K2(2), MAPK1(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPKAPK2(1), MAPKAPK3(1), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NOS3(9), NRAS(3), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCG1(7), PLCG2(7), PPP3CA(3), PPP3CB(3), PRKCA(1), PRKCG(4), PTGS2(3), PTK2(9), PXN(2), RAC3(1), RAF1(2), SH2D2A(2), SPHK1(7), SPHK2(3), SRC(3), VEGFA(1)	41640343	192	122	179	28	18	42	23	59	50	0	0.000115	0.967	1.000
219	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(1), ENPP6(2), PAFAH1B1(1), PAFAH1B2(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLD1(4), PLD2(3), PPAP2A(3), PPAP2B(1), PPAP2C(2)	13365847	54	40	52	9	3	8	9	17	17	0	0.0379	0.970	1.000
220	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(3), ARFGAP3(1), ARFGEF2(5), CLTB(1), COPA(4), GBF1(4), GPLD1(2), KDELR1(1), KDELR2(2), KDELR3(1)	9097975	25	23	25	4	1	7	3	7	7	0	0.157	0.971	1.000
221	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(1), RDH11(1), RDH13(1), RDH14(1)	2643009	5	5	5	2	1	2	0	1	1	0	0.831	0.971	1.000
222	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(2)	2272848	3	3	3	1	0	2	0	0	1	0	0.779	0.972	1.000
223	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), ATIC(2), ATP6V0C(2), GART(4), MTHFD1(4), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTR(3), SHMT1(2), SHMT2(4), TYMS(1)	10037867	28	23	27	2	0	8	1	12	7	0	0.0186	0.975	1.000
224	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK1G(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CAMKK1(1), CAMKK2(3), CREB1(1), SYT1(2)	6714282	21	19	21	4	1	5	2	7	6	0	0.291	0.975	1.000
225	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1)	2113739	2	2	2	1	0	0	0	2	0	0	0.888	0.976	1.000
226	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT5(2), B3GNT5(1), FUT1(4), FUT3(2)	4027599	10	9	10	3	1	3	1	4	1	0	0.580	0.977	1.000
227	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(2), PRKCA(1), TGM2(1)	2870851	5	5	5	2	1	1	0	1	2	0	0.701	0.977	1.000
228	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), CDC42(3), WASF1(1), WASL(2)	4628812	15	15	15	4	2	7	4	1	1	0	0.297	0.978	1.000
229	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(10), CPT1A(4), LEP(2), LEPR(4), PRKAA1(4), PRKAB2(1), PRKAG2(3)	8040720	28	26	28	5	3	5	1	10	9	0	0.290	0.979	1.000
230	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT1(2), AKT2(3), AKT3(2), FCER1A(1), FYN(1), GAB2(5), IL4(1), IL5(1), KRAS(6), LAT(1), LCP2(5), LYN(1), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK9(3), MS4A2(3), NRAS(3), PDK1(1), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCG1(7), PLCG2(7), PRKCA(1), RAC3(1), RAF1(2), SOS1(8), SOS2(4), SYK(1), TNF(1), VAV1(3), VAV3(8)	40440760	168	110	157	21	11	34	21	55	46	1	0.000128	0.979	1.000
231	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(6), ACO2(3), CS(4), DLD(4), DLST(1), FH(3), IDH1(8), IDH2(4), IDH3G(2), MDH1(1), PC(3), PCK1(6), SDHA(2), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1)	11636624	52	45	48	11	6	8	8	13	16	1	0.207	0.979	1.000
232	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), FPGS(1)	4019923	9	9	9	3	0	1	2	4	2	0	0.764	0.981	1.000
233	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(1), COPS5(1), CREB1(1), EDN1(2), EP300(11), HIF1A(3), JUN(2), LDHA(1), NOS3(9), P4HB(1)	9622891	34	29	31	5	1	10	2	14	7	0	0.141	0.981	1.000
234	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(3), CTH(2), GGT1(1), HEMK1(3), LCMT2(3), MARS(6), MAT1A(4), METTL2B(5), METTL6(3), PAPSS1(2), PAPSS2(1), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), SCLY(1), WBSCR22(2)	14081397	47	40	47	8	6	13	5	15	7	1	0.0915	0.982	1.000
235	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), ATF2(1), EGFR(6), GNAQ(1), JUN(2), MAP2K2(2), MAP2K4(4), MAP3K1(3), MAPK1(3), MAPK8(1), MEF2A(6), MEF2C(1), MEF2D(3), PAK1(3), PRKCA(1), PTK2(9), PTK2B(5), RAF1(2), SHC1(3), SOS1(8), SRC(3), SYT1(2)	19383769	72	61	71	11	2	19	8	27	15	1	0.0441	0.982	1.000
236	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR24(1), DHCR7(1), FDPS(2), GGCX(4), GGPS1(1), HMGCR(6), HSD17B7(1), IDI1(1), IDI2(1), LSS(5), MVD(3), MVK(2), NQO1(2), NSDHL(1), PMVK(3), SQLE(1), TM7SF2(2)	11056012	37	30	37	5	3	9	6	9	9	1	0.0580	0.983	1.000
237	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(5), HDC(4), TH(1), TPH1(2)	3406519	12	11	12	4	3	2	1	2	4	0	0.626	0.984	1.000
238	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), FOS(1), JUN(2), OPRK1(3), POLR2A(7), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3)	7202874	22	19	21	3	0	7	1	10	4	0	0.288	0.985	1.000
239	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	CREB1(1), CREB5(2), DUSP4(1), DUSP6(2), DUSP9(1), EEF2K(1), MAP2K2(2), MAP3K8(1), MAPK1(3), MKNK1(2), MKNK2(3), MOS(2), NFKB1(3), RAP1A(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), SHC1(3), SOS1(8), SOS2(4), TRAF3(1)	16975648	63	53	62	10	10	13	9	17	13	1	0.0172	0.985	1.000
240	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), ATIC(2), FTCD(3), GART(4), MTFMT(1), MTHFD1(4), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTR(3), SHMT1(2), SHMT2(4), TYMS(1)	10833244	30	24	29	2	0	8	1	11	10	0	0.0252	0.986	1.000
241	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(5), LARS(1), LARS2(2), PDHA1(1), PDHA2(3), PDHB(2)	5582199	16	15	16	4	1	6	1	6	2	0	0.379	0.986	1.000
242	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(1), IFNB1(2), JAK1(13), STAT1(5), TYK2(1)	6118372	24	22	22	5	1	6	2	11	4	0	0.381	0.988	1.000
243	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(6), GNAS(10), GNB1(2), IGF1R(11), MAP2K2(2), MAPK1(3), MKNK1(2), MKNK2(3), MYC(2), NGFR(3), PDGFRA(5), PPP2CA(2), PTPRR(2), RAF1(2), RPS6KA1(1), RPS6KA5(5), SHC1(3), SOS1(8), SRC(3), STAT3(4)	19157889	79	65	73	11	13	16	10	29	10	1	0.0102	0.989	1.000
244	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(5), AKT1(2), ASAH1(2), GNAI1(4), GNB1(2), ITGAV(3), ITGB3(5), MAPK1(3), PDGFA(2), PDGFRA(5), PIK3CA(13), PIK3R1(4), PLCB1(8), PRKCA(1), PTK2(9), SMPD1(4), SMPD2(4), SPHK1(7), SRC(3)	15371098	86	66	79	18	3	25	8	29	21	0	0.140	0.989	1.000
245	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADVL(2), ACSL1(1), ACSL3(2), CPT1A(4), CPT2(1), EHHADH(10), HADHA(3), PECR(3), SCP2(3)	9447068	32	23	32	7	1	5	5	9	12	0	0.381	0.990	1.000
246	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), CAMP(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(4)	3438324	10	10	10	5	2	1	1	3	3	0	0.922	0.992	1.000
247	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), IL22(1), IL22RA1(1), JAK1(13), JAK2(4), JAK3(7), SOCS3(1), STAT1(5), STAT3(4), STAT5A(2), STAT5B(1), TYK2(1)	10737387	43	36	40	8	4	8	4	20	7	0	0.222	0.992	1.000
248	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1)	4505528	8	8	8	2	0	2	0	5	1	0	0.569	0.992	1.000
249	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1)	4505528	8	8	8	2	0	2	0	5	1	0	0.569	0.992	1.000
250	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(2), CXCL12(1), CXCR4(2), FOS(1), GNAQ(1), JUN(2), MAPK14(3), MAPK8(1), PLCG1(7), PRKCA(1), PTK2B(5), SYT1(2)	7593077	28	27	27	6	1	9	2	9	7	0	0.350	0.992	1.000
251	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO3(1), FARS2(1), PAH(2), TAT(3)	4574562	9	9	9	6	0	1	3	0	5	0	0.934	0.993	1.000
252	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(1), BMPR1B(2), BMPR2(5)	3457871	8	7	8	3	1	2	1	0	4	0	0.782	0.993	1.000
253	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(2), F2(2), F2R(1), FGA(12), FGB(3), PLAT(2), PLG(3), SERPINB2(3), SERPINE1(1)	7484200	31	30	31	8	1	9	7	6	8	0	0.386	0.993	1.000
254	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3G(1), CD4(1), ICAM1(1), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1)	6222513	25	22	24	5	1	10	4	7	3	0	0.252	0.993	1.000
255	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(3), AKT3(2), BCL2(1), BCR(2), BLNK(3), CD19(2), CD22(5), CD81(2), CR2(9), CSK(1), DAG1(1), FLOT1(3), GSK3A(1), GSK3B(3), ITPR1(15), ITPR2(11), ITPR3(11), LYN(1), MAP4K1(1), MAPK1(3), NFATC1(2), NFATC2(7), NR0B2(4), PDK1(1), PIK3CA(13), PIK3CD(5), PIK3R1(4), PLCG2(7), PPP1R13B(4), PPP3CA(3), PPP3CB(3), PTPRC(8), RAF1(2), SHC1(3), SOS1(8), SOS2(4), SYK(1), VAV1(3)	41722505	164	119	158	21	17	40	24	57	25	1	1.40e-05	0.994	1.000
256	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(2), ADCY9(6), AK1(1), ARF1(1), ARF5(1), ATP6V0A1(6), ATP6V0A2(2), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), ERO1L(1), GNAS(10), PDIA4(2), PLCG1(7), PLCG2(7), PRKCA(1), SEC61A1(2), TRIM23(1)	21063462	69	57	64	9	8	17	4	24	16	0	0.0329	0.994	1.000
257	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), DPYD(6), DPYS(1), ENPP1(1), ENPP3(4), PANK1(1), PANK2(2), PANK4(4), PPCS(1), UPB1(1)	7997683	23	18	23	4	2	7	4	8	2	0	0.146	0.994	1.000
258	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	MAP2K2(2), MAPK1(3), NGFR(3), RAF1(2)	4765427	10	10	10	3	0	2	1	5	2	0	0.679	0.995	1.000
259	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), EPOR(1), FOS(1), JAK2(4), JUN(2), MAPK8(1), PLCG1(7), PTPN6(2), RAF1(2), SHC1(3), SOS1(8), STAT5A(2), STAT5B(1)	12429490	36	30	35	5	3	7	5	11	9	1	0.117	0.996	1.000
260	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(6), ACO2(3), CS(4), HAO1(1), MDH1(1), MTHFD1(4), MTHFD1L(2), MTHFD2(2)	7139632	23	22	23	5	1	5	0	9	8	0	0.418	0.996	1.000
261	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(5), BDH1(2), BDH2(1), HMGCL(2), HMGCS1(2), HMGCS2(2), OXCT1(2)	4280853	18	16	17	6	0	4	1	7	6	0	0.783	0.996	1.000
262	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), CAMK2A(6), CAMK2B(2), CAMK2G(3), F2(2), FYN(1), GNAI1(4), GNB1(2), JAK2(4), MAP2K2(2), MAPK1(3), MAPK14(3), MAPK8(1), MAPT(6), MYLK(3), PLCG1(7), PRKCA(1), PTK2B(5), RAF1(2), SHC1(3), SOS1(8), STAT1(5), STAT3(4), STAT5A(2), SYT1(2)	23927797	82	66	80	11	5	23	9	24	20	1	0.00818	0.996	1.000
263	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(6), EGFR(6), ERBB3(8), NRG1(2), UBE2D1(1)	5717894	23	22	22	9	0	5	3	9	6	0	0.882	0.996	1.000
264	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(6), CAMK2B(2), CAMK2G(3), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), NFAT5(6), PDE6A(7), PDE6B(8), SLC6A13(4), TF(3)	20584781	82	65	81	12	9	23	3	29	18	0	0.0223	0.996	1.000
265	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), FHL5(2), FSHR(4), GNAS(10), XPO1(5)	5487411	26	25	23	6	6	3	2	11	4	0	0.510	0.996	1.000
266	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(2), ST3GAL1(1), ST3GAL2(1)	4359855	9	9	9	3	1	0	0	5	3	0	0.875	0.996	1.000
267	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(1), TPI1(1)	2185055	3	3	3	3	0	0	0	2	1	0	0.945	0.997	1.000
268	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	FCER1A(1), FOS(1), JUN(2), LYN(1), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAPK1(3), MAPK8(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PAK2(3), PIK3CA(13), PIK3R1(4), PLA2G4A(8), PLCG1(7), PPP3CA(3), PPP3CB(3), RAF1(2), SHC1(3), SOS1(8), SYK(1), SYT1(2), VAV1(3)	24142150	96	74	89	16	9	17	13	32	24	1	0.0153	0.997	1.000
269	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(9), BIRC2(4), BIRC3(1), CASP10(2), CASP3(3), CASP8(1), CASP9(1), DFFB(1), GZMB(2), PRF1(4), SCAP(5), SREBF1(3), SREBF2(3)	10646841	39	33	39	9	3	10	1	9	15	1	0.518	0.997	1.000
270	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(1), GNA12(1), GNA13(1), GNAQ(1), GNB1(2), MYLK(3), PLCB1(8), PPP1R12B(4), PRKCA(1), ROCK1(6)	11611646	31	27	31	5	0	6	4	10	11	0	0.229	0.997	1.000
271	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), CRY1(1), CRY2(1), CSNK1E(3), NPAS2(4), NR1D1(1), PER1(6), PER2(4), PER3(5)	9679464	26	23	26	5	1	8	3	9	4	1	0.297	0.997	1.000
272	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(2), IL4R(1), JAK1(13), JAK2(4), TYK2(1)	5858614	23	21	21	5	1	3	1	10	8	0	0.611	0.997	1.000
273	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(2), IL4R(1), JAK1(13), JAK2(4), TYK2(1)	5858614	23	21	21	5	1	3	1	10	8	0	0.611	0.997	1.000
274	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(6), ACO2(3), CS(4), HAO1(1), MDH1(1), MTHFD1(4), MTHFD1L(2), MTHFD2(2)	7491796	23	22	23	5	1	5	0	9	8	0	0.422	0.998	1.000
275	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(3), ARSD(3), ARSE(2), CYP11B1(4), CYP11B2(5), HSD11B1(2), HSD17B3(2), HSD17B8(1), HSD3B1(2), SRD5A1(1), STS(4), SULT1E1(1), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5)	15215028	48	44	48	9	4	15	5	10	14	0	0.163	0.998	1.000
276	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(6), EGFR(6), MAP3K1(3), MAPK14(3), NCOR2(14), RARA(1), RXRA(2)	9985932	35	33	32	8	7	6	6	8	8	0	0.346	0.998	1.000
277	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(10), HADH(1), HADHA(3), HSD17B4(1), NTAN1(2), SIRT1(2), SIRT2(2), VNN2(1)	6711713	24	14	24	6	1	6	6	7	4	0	0.311	0.998	1.000
278	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), ECHS1(2), EHHADH(10), HADHA(3), SDS(2)	6880346	25	16	25	6	0	5	4	11	5	0	0.404	0.998	1.000
279	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), CASP3(3), CASP6(2), CASP8(1), CASP9(1), DFFB(1), DIABLO(1)	7613601	27	23	26	6	3	9	1	5	9	0	0.457	0.998	1.000
280	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(1), HSD17B3(2), HSD17B4(1), HSD17B7(1), HSD3B1(2)	4531073	10	10	10	6	2	2	0	2	4	0	0.882	0.998	1.000
281	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(2), EPX(3), ESCO1(2), ESCO2(3), HPD(2), LPO(4), MAOA(1), MAOB(8), MPO(5), NAT6(1), PNPLA3(1), PRDX6(1), SH3GLB1(2), TAT(3), TPO(13)	19185495	58	47	58	8	3	14	8	19	14	0	0.0102	0.998	1.000
282	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(4), FUT9(4), GBGT1(3), GLA(1), HEXA(3), HEXB(1), ST3GAL1(1), ST3GAL2(1)	5613326	19	18	19	7	2	0	0	11	6	0	0.851	0.998	1.000
283	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(5), DLL1(2), FURIN(5), NOTCH1(7), PSEN1(2)	5601243	21	21	21	6	5	4	4	6	2	0	0.275	0.999	1.000
284	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(4), AASS(5)	3851709	11	11	11	4	0	3	2	4	2	0	0.787	0.999	1.000
285	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC3A(1), APOBEC3B(2), APOBEC3G(1), APOBEC4(2)	4083245	9	9	9	3	0	0	0	5	4	0	0.922	0.999	1.000
286	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), DCXR(1), GUSB(8), UCHL1(1), UCHL3(2), UGDH(2), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5)	9672739	32	25	31	8	0	7	1	7	17	0	0.808	0.999	1.000
287	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(3), CREB1(1), DAXX(1), HMGN1(1), HSPB1(1), HSPB2(1), MAP2K4(4), MAP2K6(2), MAP3K1(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MEF2A(6), MEF2C(1), MEF2D(3), MKNK1(2), MYC(2), PLA2G4A(8), RIPK1(4), RPS6KA5(5), SHC1(3), STAT1(5), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1)	21268047	79	63	78	13	8	16	9	29	17	0	0.0367	0.999	1.000
288	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(7), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF5(1), GSK3B(3), PPP1CA(2)	6486048	19	19	19	5	0	10	0	3	6	0	0.345	0.999	1.000
289	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(3), CREBBP(6), DFFB(1), GZMA(3), GZMB(2), HMGB2(1), NME1(2), PRF1(4)	6005111	22	22	22	9	2	4	2	7	7	0	0.864	0.999	1.000
290	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(3), G6PD(1), GCLC(1), GCLM(1), GGT1(1), GPX7(1), GSR(3), GSS(1), GSTA2(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM3(1), GSTM5(1), GSTP1(2), GSTZ1(2), IDH1(8), IDH2(4), MGST2(1), OPLAH(5)	13343896	40	34	37	7	7	6	3	16	8	0	0.0932	0.999	1.000
291	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(5), CHAT(4), CHKA(1), PCYT1A(3), PDHA1(1), PDHA2(3)	3884724	17	16	17	7	2	2	1	9	3	0	0.767	0.999	1.000
292	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), FARSB(1), PAH(2), TAT(3)	4863921	9	9	9	6	0	2	3	0	4	0	0.970	0.999	1.000
293	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(2), MBTPS1(4), MBTPS2(1), SCAP(5), SREBF1(3), SREBF2(3)	7113483	20	18	20	5	3	3	2	4	7	1	0.404	0.999	1.000
294	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SRP54(1), SRP68(1), SRP72(3), SRPR(2)	4184650	9	6	9	2	1	3	0	1	4	0	0.763	0.999	1.000
295	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(6), GNAQ(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCA(1), SP1(2), SP3(3), SYT1(2)	11678491	46	39	44	10	5	8	5	18	10	0	0.264	0.999	1.000
296	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	145	APC(12), APC2(3), AXIN1(25), AXIN2(6), BTRC(5), CAMK2A(6), CAMK2B(2), CAMK2G(3), CCND1(1), CCND2(3), CER1(1), CHD8(2), CREBBP(6), CSNK1A1(2), CSNK1A1L(3), CSNK1E(3), CSNK2A1(2), CTBP1(1), CTNNB1(102), CUL1(2), CXXC4(1), DAAM1(7), DAAM2(6), DKK1(1), DKK2(4), DVL1(3), DVL2(6), DVL3(1), EP300(11), FBXW11(1), FZD1(2), FZD10(1), FZD2(4), FZD3(2), FZD4(2), FZD6(2), FZD7(3), FZD8(2), FZD9(3), GSK3B(3), JUN(2), LEF1(2), LRP5(2), LRP6(2), MAP3K7(3), MAPK10(3), MAPK8(1), MAPK9(3), MMP7(3), MYC(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NKD1(2), NKD2(3), NLK(2), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), PPP3CA(3), PPP3CB(3), PRICKLE1(5), PRICKLE2(6), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), PSEN1(2), RAC3(1), ROCK1(6), ROCK2(3), SENP2(3), SFRP2(2), SFRP5(3), SIAH1(4), SMAD2(1), SMAD3(3), SMAD4(5), TBL1X(1), TBL1XR1(4), TBL1Y(2), TCF7(2), TCF7L1(3), TCF7L2(3), TP53(117), VANGL1(3), VANGL2(1), WIF1(6), WNT1(2), WNT11(1), WNT2(3), WNT3A(2), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2)	92550845	573	272	458	82	34	117	53	212	155	2	4.73e-10	0.999	1.000
297	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(2), FUT1(4), FUT9(4), GBGT1(3), GLA(1), HEXA(3), HEXB(1), ST3GAL1(1), ST3GAL2(1)	5946789	22	21	22	7	2	2	0	12	6	0	0.760	0.999	1.000
298	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(2), APOA1(2), APOA2(1), CD36(3), CITED2(2), CPT1B(4), CREBBP(6), DUSP1(1), DUT(1), EHHADH(10), EP300(11), FABP1(1), HSD17B4(1), INS(1), JUN(2), LPL(1), MAPK1(3), ME1(1), MRPL11(1), MYC(2), NCOA1(5), NCOR1(10), NCOR2(14), NFKBIA(2), NR0B2(4), NR1H3(4), NR2F1(2), NRIP1(1), PDGFA(2), PIK3CA(13), PIK3R1(4), PPARA(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PTGS2(3), RB1(24), RELA(4), RXRA(2), SP1(2), STAT5A(2), STAT5B(1), TNF(1)	36350805	168	112	159	29	11	26	20	58	50	3	0.0149	0.999	1.000
299	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(11), CD38(3), ENPP1(1), ENPP3(4), NMNAT1(2), NNT(4), NT5E(1), NT5M(2)	8252110	28	24	27	7	0	15	3	6	4	0	0.323	0.999	1.000
300	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	CNR1(3), CNR2(1), DNMT1(2), MTNR1A(2), MTNR1B(3), PTGER1(1), PTGER2(3), PTGER4(1), PTGFR(2), PTGIR(2)	6573798	20	19	20	5	1	5	4	9	1	0	0.267	0.999	1.000
301	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(4), FUT3(2), FUT5(1)	2859652	7	7	7	4	2	0	1	3	1	0	0.878	0.999	1.000
302	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA2A(2), ADORA2B(1), ADORA3(2), LTB4R(1), P2RY1(4), P2RY2(1), P2RY6(1)	3179701	13	13	13	6	0	1	2	8	2	0	0.843	0.999	1.000
303	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(10), GNB1(2), PPP2CA(2), PRKAA1(4), PRKAB2(1), PRKACB(2), PRKACG(2), PRKAG2(3), PRKAR1B(1), PRKAR2B(3)	8865671	35	31	32	8	7	8	1	13	6	0	0.451	0.999	1.000
304	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), CREB1(1), FOS(1), GNAI1(4), GNAQ(1), GNAS(10), GNB1(2), JUN(2), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), RAF1(2), RPS6KA3(15), SYT1(2)	19872507	85	65	79	15	11	19	6	29	20	0	0.0499	0.999	1.000
305	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADH(1), HADHA(3), HADHB(4), HSD17B4(1), PPT1(2), PPT2(3)	4844496	17	15	16	6	2	5	2	6	2	0	0.609	0.999	1.000
306	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(10), GNA12(1), PRKACB(2), PRKACG(2), PRKAR2B(3)	5689819	18	16	18	6	0	7	0	6	5	0	0.725	0.999	1.000
307	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CBS(3), CTH(2), DNMT1(2), DNMT3A(9), DNMT3B(2), MARS(6), MAT1A(4), MTAP(2), MTFMT(1), MTR(3), SRM(2), TAT(3)	11786215	39	34	38	8	5	6	0	13	15	0	0.358	0.999	1.000
308	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(3), CTH(2), DNMT1(2), DNMT3A(9), DNMT3B(2), MARS(6), MAT1A(4), MTR(3)	9864088	31	27	31	6	4	5	0	12	10	0	0.386	0.999	1.000
309	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(2), UGP2(3)	2850554	6	6	6	4	0	2	0	2	2	0	0.959	0.999	1.000
310	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(2), CASP3(3), CASP6(2), CASP8(1), CFLAR(2), DAXX(1), DFFB(1), FADD(1), FAF1(2), JUN(2), LMNA(2), LMNB2(2), MAP2K4(4), MAP3K1(3), MAP3K7(3), MAPK8(1), PAK1(3), PAK2(3), PRKDC(6), PTPN13(14), RB1(24), RIPK2(2), SPTAN1(7)	24281774	91	77	90	15	2	14	5	25	44	1	0.115	1.000	1.000
311	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3G(1), IFNG(3), IL2RA(1), IL4(1), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), TOB1(4), TOB2(1)	6064526	20	19	20	7	1	5	1	8	5	0	0.821	1.000	1.000
312	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS3(1), DHRS7(1), HSD3B7(1), PON1(1), PON2(1), PON3(3), RDH11(1), RDH13(1), RDH14(1)	5002837	12	11	12	4	2	4	0	5	1	0	0.718	1.000	1.000
313	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(3), DFFB(1), GZMB(2), HMGB1(2), HMGB2(1), TOP2A(4), TOP2B(6)	5978187	19	18	19	9	1	2	3	7	6	0	0.960	1.000	1.000
314	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(2), JAK1(13), PTPRU(2), REG1A(1), STAT1(5), TYK2(1)	7050663	26	23	24	6	1	7	2	12	4	0	0.476	1.000	1.000
315	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(6), EP300(11), FYN(1), IL2RG(1), IL7(1), IL7R(1), JAK1(13), JAK3(7), LCK(4), NMI(2), PIK3CA(13), PIK3R1(4), PTK2B(5), STAT5A(2), STAT5B(1)	15866436	73	62	65	14	4	19	6	29	15	0	0.0922	1.000	1.000
316	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ARG2(1), ASL(1), CKB(1), CKM(2), CKMT1B(1), CKMT2(2), CPS1(12), GAMT(1), GATM(4), GLUD1(3), NAGS(1), OAT(2), ODC1(3), PYCR1(1), SMS(1)	10612390	38	30	38	9	2	10	8	7	11	0	0.234	1.000	1.000
317	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), MIOX(1), UGDH(2)	4829851	10	8	10	3	0	3	0	5	2	0	0.676	1.000	1.000
318	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(3), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2E1(4), CYP3A4(1), CYP3A43(1), CYP3A5(4), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), RDH11(1), RDH13(1), RDH14(1)	13738699	49	44	47	10	6	10	3	15	15	0	0.150	1.000	1.000
319	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(9), BIRC2(4), BIRC3(1), CASP10(2), CASP3(3), CASP4(3), CASP6(2), CASP8(1), CASP9(1), DFFB(1), GZMB(2), LMNA(2), LMNB2(2), PRF1(4)	10929741	37	31	37	8	1	12	1	10	13	0	0.509	1.000	1.000
320	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(1), SNCA(1), SNCAIP(2), UBE2E2(1), UBE2L3(1)	3503895	9	9	9	7	0	2	2	4	1	0	0.964	1.000	1.000
321	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA1(1), FUCA2(1), GLB1(3), HEXA(3), HEXB(1), LCT(6), MAN2B1(2), MAN2B2(3), MAN2C1(5), MANBA(1), NEU1(2), NEU2(4), NEU3(2), NEU4(2)	11833282	38	33	37	9	5	9	6	10	8	0	0.215	1.000	1.000
322	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(3), B4GALT2(1), B4GALT3(2), B4GALT5(1), DDOST(1), DPM1(1), FUT8(2), MAN1A1(3), MAN1B1(1), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), RPN1(1), RPN2(2), ST6GAL1(1)	11430884	34	28	34	7	3	9	2	12	8	0	0.235	1.000	1.000
323	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2), MTMR2(1), MTMR6(4), PHPT1(1), TPK1(2)	3584135	11	10	11	5	1	1	0	7	2	0	0.944	1.000	1.000
324	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), ADRB2(3), CFTR(3), GNAS(10), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), SLC9A3R1(1)	7584063	30	26	27	7	6	9	2	10	3	0	0.379	1.000	1.000
325	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPN2(1), CAPNS1(1), EP300(11), HDAC2(3), MEF2D(3), NFATC1(2), NFATC2(7), PPP3CA(3), PPP3CB(3), PRKCA(1), SYT1(2)	13683169	42	35	40	9	4	8	2	19	9	0	0.310	1.000	1.000
326	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(3), GAD1(5), GAD2(1), GGT1(1)	3303113	11	11	11	5	2	2	0	5	2	0	0.864	1.000	1.000
327	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1R(5), TNF(1)	3615279	9	8	9	6	3	0	1	3	2	0	0.934	1.000	1.000
328	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(1), CASP8(1), FADD(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1)	4755756	11	11	11	5	0	4	1	3	3	0	0.873	1.000	1.000
329	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), AOX1(11), DCT(3), DDC(2), GSTZ1(2), HGD(4), HPD(2), MAOA(1), MAOB(8), TAT(3), TH(1), TPO(13), TYR(5)	17964727	74	61	74	14	4	18	8	25	19	0	0.0641	1.000	1.000
330	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1)	7522765	21	20	21	6	0	3	2	8	8	0	0.679	1.000	1.000
331	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), CABIN1(5), CAMK1(1), CAMK1G(2), HDAC5(4), IGF1R(11), INS(1), INSR(4), MAP2K6(2), MAPK14(3), MAPK7(3), MEF2A(6), MEF2C(1), MEF2D(3), MYOD1(1), NFATC1(2), NFATC2(7), PIK3CA(13), PIK3R1(4), PPP3CA(3), PPP3CB(3), SYT1(2)	19929014	83	60	78	16	9	15	12	32	15	0	0.0496	1.000	1.000
332	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(12), AR(14), ASAH1(2), CAMP(1), CCL13(1), CCL15(1), CCL16(1), DAG1(1), EGFR(6), GNA15(1), GNAI1(4), GNAQ(1), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), KCNJ3(3), MAPK1(3), MAPK10(3), MAPK14(3), PHKA2(3), PIK3CA(13), PIK3CD(5), PIK3R1(4), PITX2(1), PTX3(1), RAF1(2), SRC(3)	30672860	133	96	120	23	11	31	14	52	24	1	0.0136	1.000	1.000
333	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(3), G6PD(1), GCLC(1), GCLM(1), GGT1(1), GSS(1), GSTA2(1), GSTA4(1), GSTM3(1), GSTM5(1), GSTP1(2), GSTZ1(2), IDH1(8), IDH2(4), MGST2(1)	10862285	29	27	26	6	5	5	1	12	6	0	0.304	1.000	1.000
334	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), NCK1(1), NCKAP1(3), NTRK1(5), PSMA7(3), WASF1(1), WASF2(2), WASF3(2), WASL(2)	8667168	28	26	27	7	3	13	5	4	3	0	0.203	1.000	1.000
335	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(2), CYP2A6(3), CYP2A7(4), XDH(8)	4490080	17	16	17	5	0	7	0	8	2	0	0.803	1.000	1.000
336	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(2), GPI(1), HK1(3), PFKL(1), PKLR(3), TPI1(1)	5148143	12	12	12	5	1	2	1	5	3	0	0.711	1.000	1.000
337	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(4), MDH1(1), ME1(1), PC(3), PDHA1(1), SLC25A1(3)	5180489	16	14	16	8	2	4	2	4	4	0	0.916	1.000	1.000
338	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), IL4(1), IL5(1), JUNB(1), MAP2K3(2), MAPK14(3), NFATC1(2), NFATC2(7), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3)	6995965	26	24	26	8	2	5	2	11	6	0	0.744	1.000	1.000
339	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	DUSP1(1), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MAPKAPK5(3), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PIK3CA(13), PIK3CD(5), PIK3R1(4), SYT1(2), TRAF3(1), TRAF5(2), TRAF6(2)	20624135	65	54	60	12	4	14	7	21	19	0	0.117	1.000	1.000
340	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(1), GLB1(3), GUSB(8), HEXA(3), HEXB(1), IDS(1), IDUA(1), LCT(6), NAGLU(3)	8475616	27	25	25	8	2	4	5	7	9	0	0.385	1.000	1.000
341	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), FOS(1), JAK2(4), PTPN6(2), RAF1(2), SHC1(3), SOS1(8), STAT5A(2), STAT5B(1)	10112812	25	24	25	5	3	3	4	10	4	1	0.320	1.000	1.000
342	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(2), GPT(1), LDHA(1), LDHB(1), LDHC(1), MAPK14(3), NCL(6)	5102549	18	14	17	7	2	3	1	8	4	0	0.851	1.000	1.000
343	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(4), ABCG2(2), BCHE(2), CES1(3), CES2(2), CYP3A4(1), CYP3A5(4), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1)	12817743	32	28	32	7	0	11	3	9	9	0	0.274	1.000	1.000
344	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(2), CARS2(1), CTH(2), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), MPST(1), SDS(2), SULT1C2(1), SULT1C4(1), SULT4A1(1)	7113624	18	17	18	7	0	6	2	5	5	0	0.838	1.000	1.000
345	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(3), AKT3(2), BCR(2), BLNK(3), CD19(2), CSK(1), DAG1(1), EPHB2(4), ITPKA(1), ITPKB(4), LYN(1), MAP2K2(2), MAPK1(3), NFAT5(6), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PIK3CA(13), PIK3CD(5), PIK3R1(4), PLCG2(7), PPP1R13B(4), RAF1(2), SERPINA4(2), SHC1(3), SOS1(8), SOS2(4), SYK(1), VAV1(3)	30174391	101	77	96	16	8	30	15	31	16	1	0.00785	1.000	1.000
346	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(1), DPYD(6), DPYS(1), ENPP1(1), ENPP3(4), PANK1(1), PANK2(2), PANK4(4), PPCS(1), UPB1(1), VNN1(1)	9912491	25	20	25	5	2	8	4	9	2	0	0.200	1.000	1.000
347	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX5(3), CYP4F2(1), CYP4F3(2), EPX(3), GGT1(1), LPO(4), MPO(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PRDX1(1), PRDX2(2), PRDX6(1), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(3), TPO(13)	16097893	62	51	60	13	10	8	8	19	17	0	0.0953	1.000	1.000
348	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(2), CTH(2), LDHA(1), LDHB(1), LDHC(1), MPST(1)	3802812	8	8	8	4	0	5	0	2	1	0	0.858	1.000	1.000
349	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(1), ITGAL(5), ITGAM(6), ITGB2(8), SELE(1)	6042336	25	23	24	9	2	9	1	8	5	0	0.855	1.000	1.000
350	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(4), CYP7A1(1), HADHB(4), SOAT2(1), SRD5A1(1)	13154919	40	35	40	9	3	10	4	17	6	0	0.201	1.000	1.000
351	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT2(1), B4GALT3(2), CHST2(3), CHST6(2), FUT8(2), ST3GAL1(1), ST3GAL2(1)	6818649	15	15	15	5	3	2	1	5	4	0	0.685	1.000	1.000
352	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(2), ARRB2(1), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CLCA1(8), CLCA2(10), CLCA4(2), CNGA3(11), CNGA4(3), CNGB1(4), GNAL(2), GUCA1A(1), PDE1C(9), PRKACA(2), PRKACB(2), PRKACG(2), PRKG1(6), PRKG2(4), PRKX(3)	17540362	87	61	84	18	9	24	9	24	19	2	0.0583	1.000	1.000
353	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), CAMP(1), CREB1(1), CREB5(2), MAPK1(3), RAF1(2), SNX13(2), SRC(3), TERF2IP(1)	6611335	17	17	17	5	2	2	2	7	4	0	0.681	1.000	1.000
354	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(3), HK2(3), HK3(5), IMPA1(2), IMPA2(2), ISYNA1(1), PGM1(1), PGM3(2), TGDS(1)	6733517	20	20	20	9	0	3	3	10	4	0	0.800	1.000	1.000
355	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(3), HK2(3), HK3(5), IMPA1(2), PGM1(1), PGM3(2), TGDS(1)	5895828	17	17	17	9	0	3	3	8	3	0	0.852	1.000	1.000
356	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), AKT1(2), ANGPTL2(1), DAG1(1), DGKA(4), GCA(1), ITGA9(5), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), MAPK1(3), NR1I3(2), PAK1(3), PDE3A(8), PDE3B(2), PIK3C2G(7), PIK3CA(13), PIK3CD(5), PIK3R1(4), PSME1(1), RIPK3(6), SGCB(1), VASP(2)	28134153	114	83	108	20	12	30	12	43	17	0	0.0143	1.000	1.000
357	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(2), AKT2(3), AKT3(2), BCL10(1), BLNK(3), CARD11(11), CD19(2), CD22(5), CD79B(1), CD81(2), CHUK(8), CR2(9), FOS(1), GSK3B(3), IKBKB(4), JUN(2), KRAS(6), LILRB3(3), LYN(1), MALT1(3), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKB2(2), NFKBIA(2), NRAS(3), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG2(7), PPP3CA(3), PPP3CB(3), PTPN6(2), RAC3(1), RASGRP3(1), SYK(1), VAV1(3), VAV3(8)	42796837	172	115	164	27	12	48	25	54	33	0	0.000324	1.000	1.000
358	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(1), AGT(1), AGTR1(2), ANPEP(3), CPA3(3), CTSA(1), CTSG(1), ENPEP(2), LNPEP(6), MME(6), THOP1(3)	11883066	33	26	32	9	0	8	2	9	14	0	0.563	1.000	1.000
359	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	DLG4(3), EPHB2(4), F2(2), F2RL3(1), JUN(2), MAP2K5(1), MAPK1(3), MAPK7(3), MAPK8(1), MYEF2(3), PLD1(4), PLD2(3), PLD3(4), PTK2(9), RAF1(2), RASAL1(4), SRC(3), VAV1(3)	15713522	55	42	54	9	2	16	9	23	5	0	0.0313	1.000	1.000
360	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(12), ASAH1(2), CAMP(1), DAG1(1), DLG4(3), EPHB2(4), GNAI1(4), GNAQ(1), ITPR1(15), ITPR2(11), ITPR3(11), KCNJ3(3), MAPK1(3), PITX2(1), PTX3(1), RHO(3), RYR1(31)	26376624	109	80	106	19	14	24	7	40	23	1	0.0212	1.000	1.000
361	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	CHUK(8), CRADD(1), IKBKB(4), JUN(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP3K1(3), MAP4K2(4), MAPK14(3), MAPK8(1), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TNF(1), TNFRSF1A(1)	14227411	49	38	49	10	3	11	6	14	15	0	0.342	1.000	1.000
362	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF2B2(2), EIF2B3(2), EIF2B4(1), EIF2B5(1), EIF2S2(1), EIF2S3(1), ELAVL1(4), FLT1(4), FLT4(6), HIF1A(3), KDR(7), NOS3(9), PIK3CA(13), PIK3R1(4), PLCG1(7), PRKCA(1), PTK2(9), PXN(2), SHC1(3)	19626231	82	69	74	18	7	16	4	30	25	0	0.186	1.000	1.000
363	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ENPP1(1), ENPP3(4), FLAD1(2), RFK(1), TYR(5)	5519999	24	20	24	8	0	6	5	9	4	0	0.674	1.000	1.000
364	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(4), CANX(1), CD4(1), CD74(1), CD8A(1), CD8B(1), CIITA(6), CREB1(1), CTSB(2), CTSS(1), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOB(1), HLA-DPB1(5), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(3), HLA-G(3), HSP90AA1(5), HSP90AB1(4), HSPA5(1), IFI30(2), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), KIR2DL3(3), KLRC1(1), KLRC3(2), KLRC4(1), NFYA(2), NFYB(1), NFYC(2), PDIA3(1), PSME1(1), RFX5(3), RFXAP(1), TAP1(2)	26663663	99	77	97	20	5	14	9	38	33	0	0.267	1.000	1.000
365	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS3(1), DHRS7(1), ESCO1(2), ESCO2(3), NAT6(1), PNPLA3(1), SH3GLB1(2)	9099240	12	11	12	3	1	3	1	6	1	0	0.415	1.000	1.000
366	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(5), AKT1(2), BAX(3), BCL2(1), CSF2RB(2), IGF1R(11), KIT(12), KITLG(2), PIK3CA(13), PIK3R1(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3)	12355587	63	48	56	16	6	13	7	22	15	0	0.314	1.000	1.000
367	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), XYLT1(3), XYLT2(1)	3940176	11	11	11	9	0	3	2	5	1	0	0.994	1.000	1.000
368	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), XYLT1(3), XYLT2(1)	3940176	11	11	11	9	0	3	2	5	1	0	0.994	1.000	1.000
369	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(1), GLB1(3), HEXA(3), HEXB(1), LCT(6), SLC33A1(2), ST3GAL1(1), ST3GAL2(1), ST6GALNAC3(2), ST6GALNAC5(3), ST8SIA5(2)	9218875	26	24	25	8	1	5	8	5	7	0	0.421	1.000	1.000
370	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK1G(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), ESRRA(2), HDAC5(4), MEF2A(6), MEF2C(1), MEF2D(3), PPARA(3), PPP3CA(3), PPP3CB(3), SLC2A4(2), SYT1(2)	12013009	43	36	42	10	4	9	2	21	7	0	0.325	1.000	1.000
371	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(3), GPR161(4), GPR34(1), GPR45(1), GPR65(2), GPR68(3)	5502944	16	16	16	6	3	3	1	8	1	0	0.768	1.000	1.000
372	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(10), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), ATP7A(6), ATP7B(3), COX10(1), COX5A(2), COX5B(2), COX6B1(2), NDUFA10(1), NDUFA5(2), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFB7(2), NDUFS1(2), NDUFS2(2), NDUFV2(2), SDHA(2), SDHB(1), SHMT1(2), UQCRB(1)	21624045	74	61	73	14	2	25	6	27	14	0	0.0693	1.000	1.000
373	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(4), ALOX5(3), GGT1(1), PLA2G6(3), PTGIS(2), PTGS1(2), PTGS2(3)	8902094	18	17	18	7	8	0	0	5	5	0	0.744	1.000	1.000
374	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(2), CAPN2(1), CAPNS1(1), CXCR3(3), EGF(6), EGFR(6), ITGA1(5), MAPK1(3), MYLK(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTK2(9), PXN(2), TLN1(10)	18934784	60	49	59	11	3	21	5	17	14	0	0.122	1.000	1.000
375	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ACADM(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC2(2), AOC3(1), DPYD(6), DPYS(1), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADHA(3), HIBCH(6), SMS(1), SRM(2), UPB1(1)	15182787	52	37	50	12	3	12	6	22	9	0	0.156	1.000	1.000
376	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), HLA-DRA(1), HLA-DRB1(1), IFNG(3), IFNGR1(3), IFNGR2(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL18(2), IL18R1(2), IL2RA(1), IL4(1), IL4R(1)	7085266	34	28	34	10	0	8	4	15	7	0	0.541	1.000	1.000
377	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(1), CASP3(3), CASP8(1), CRADD(1), DFFB(1), FADD(1), JUN(2), LMNA(2), LMNB2(2), MADD(4), MAP2K4(4), MAP3K1(3), MAP3K7(3), MAPK8(1), PAK1(3), PAK2(3), PRKDC(6), RB1(24), RIPK1(4), SPTAN1(7), TNF(1), TNFRSF1A(1)	22656245	78	67	77	16	1	9	5	19	43	1	0.399	1.000	1.000
378	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(3), ASRGL1(1), CA1(1), CA14(1), CA4(2), CA5A(1), CA5B(1), CA6(1), CA8(1), CA9(7), CPS1(12), CTH(2), GLS(4), GLS2(1), GLUD1(3), GLUD2(5), GLUL(1)	11875556	47	41	47	12	3	12	12	12	8	0	0.226	1.000	1.000
379	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(3), ARSD(3), ARSE(2), CYP11B1(4), CYP11B2(5), CYP19A1(1), HEMK1(3), HSD11B1(2), HSD17B3(2), HSD17B7(1), HSD17B8(1), HSD3B1(2), LCMT2(3), METTL2B(5), METTL6(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), SRD5A1(1), STS(4), SULT1E1(1), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5), WBSCR22(2)	27278284	87	72	86	16	8	23	9	24	22	1	0.0910	1.000	1.000
380	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3G(1), FOS(1), FYN(1), JUN(2), LAT(1), LCK(4), MAP2K4(4), MAP3K1(3), MAPK8(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKBIA(2), PIK3CA(13), PIK3R1(4), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCA(1), RAF1(2), RASA1(10), RELA(4), SHC1(3), SOS1(8), SYT1(2), VAV1(3), ZAP70(3)	27020768	107	80	100	22	8	19	12	39	28	1	0.144	1.000	1.000
381	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(4), AASS(5), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), ATP6V0C(2), BBOX1(3), DLST(1), DOT1L(7), ECHS1(2), EHHADH(10), EHMT1(4), EHMT2(5), GCDH(1), HADHA(3), PLOD1(1), PLOD2(6), PLOD3(1), SDS(2), SHMT1(2), SHMT2(4)	20854876	80	56	80	17	3	20	10	26	21	0	0.144	1.000	1.000
382	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(3), GSS(1), NFKB1(3), NOX1(3), RELA(4), TNF(1), XDH(8)	5698410	23	20	23	8	0	7	3	9	4	0	0.775	1.000	1.000
383	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(4), ACTN2(6), ACTN4(2), ARHGAP5(3), BCAR1(3), CDC42(3), CDH5(2), CLDN1(1), CLDN16(3), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(3), CLDN4(1), CLDN5(1), CLDN8(2), CLDN9(2), CTNNA1(3), CTNNA2(10), CTNNA3(5), CTNNB1(102), CTNND1(3), CXCL12(1), CXCR4(2), CYBA(2), CYBB(2), ESAM(2), EZR(1), F11R(1), GNAI1(4), GNAI2(1), GNAI3(1), ICAM1(1), ITGA4(5), ITGAL(5), ITGAM(6), ITGB2(8), ITK(1), JAM2(3), JAM3(5), MAPK11(1), MAPK12(1), MAPK14(3), MLLT4(3), MMP2(1), MMP9(3), MSN(3), NCF1(1), NCF2(1), NCF4(2), NOX1(3), NOX3(5), OCLN(3), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PLCG2(7), PRKCA(1), PRKCG(4), PTK2(9), PTK2B(5), PTPN11(4), PXN(2), RAP1A(2), RAPGEF3(2), RAPGEF4(2), RHOH(1), ROCK1(6), ROCK2(3), SIPA1(2), THY1(1), TXK(2), VASP(2), VAV1(3), VAV3(8), VCAM1(3), VCL(3)	71551991	359	205	275	50	17	98	49	134	61	0	4.68e-08	1.000	1.000
384	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(12), ASAH1(2), CAMP(1), CASP3(3), CREB1(1), CREB5(2), DAG1(1), EPHB2(4), FOS(1), GNAQ(1), ITPKA(1), ITPKB(4), JUN(2), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3)	16333098	54	48	54	12	3	8	6	18	18	1	0.405	1.000	1.000
385	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH9A1(1), AOC2(2), AOC3(1), DDC(2), HARS(1), HDC(4), MAOA(1), MAOB(8), PRPS1(1)	13790583	30	24	30	6	2	6	2	12	8	0	0.243	1.000	1.000
386	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(8), APOA1(2), APOA4(2), APOE(1), CETP(2), CYP7A1(1), DGAT1(4), HMGCR(6), LCAT(3), LDLR(2), LIPC(2), LPL(1), LRP1(19)	15296221	53	45	53	12	5	12	9	19	6	2	0.226	1.000	1.000
387	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(2), CAMP(1), CREB1(1), CREB5(2), CREBBP(6), DAG1(1), EGR2(1), EGR3(2), EGR4(1), GNAQ(1), JUN(2), MAP1B(15), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), NTRK1(5), PIK3C2G(7), PIK3CA(13), PIK3CD(5), PIK3R1(4), PTPN11(4), RPS6KA3(15), SHC1(3), SRC(3), TERF2IP(1), TH(1)	30086479	117	85	111	23	9	25	11	39	32	1	0.0365	1.000	1.000
388	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(3), CD79B(1), FOS(1), JUN(2), LYN(1), MAP3K1(3), MAPK14(3), MAPK8(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCA(1), RAF1(2), SHC1(3), SOS1(8), SYK(1), SYT1(2), VAV1(3)	21438349	66	53	64	13	8	14	10	22	11	1	0.0834	1.000	1.000
389	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREB1(1), CREBBP(6), EP300(11), NCOA3(10), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RARA(1), RXRA(2)	11648855	39	32	37	10	0	12	2	14	11	0	0.623	1.000	1.000
390	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(8), IFNG(3), IKBKB(4), IL4(1), JUN(2), MAP3K1(3), MAP3K5(1), MAP4K5(7), MAPK14(3), MAPK8(1), NFKB1(3), NFKBIA(2), RELA(4)	11230841	43	33	42	11	1	13	5	14	10	0	0.480	1.000	1.000
391	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(5), GABRA2(7), GABRA3(1), GABRA4(6), GABRA5(4), GABRA6(7), GPHN(6), SRC(3), UBQLN1(3)	7219873	42	36	39	13	1	8	1	21	11	0	0.808	1.000	1.000
392	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(1), CAMK1G(2), FPR1(1), GNA15(1), GNB1(2), MAP2K2(2), MAP2K3(2), MAP2K6(2), MAP3K1(3), MAPK1(3), MAPK14(3), NCF1(1), NCF2(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKBIA(2), PAK1(3), PIK3C2G(7), PLCB1(8), PPP3CA(3), PPP3CB(3), RAF1(2), RELA(4), SYT1(2)	22214157	79	58	78	17	6	17	10	32	14	0	0.201	1.000	1.000
393	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(6), EP300(11), ESR1(6), MAPK1(3), PELP1(5), SRC(3)	8573034	34	29	33	10	1	12	3	12	6	0	0.469	1.000	1.000
394	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(14), ESR1(6), ESR2(1), ESRRA(2), HNF4A(3), NPM1(1), NR0B1(3), NR1D1(1), NR1D2(1), NR1H2(2), NR1H3(4), NR1I2(3), NR1I3(2), NR2C2(2), NR2E1(1), NR2F1(2), NR2F2(4), NR2F6(1), NR3C1(3), NR4A1(3), NR4A2(6), NR5A1(2), NR5A2(3), PGR(5), PPARA(3), PPARG(1), RARA(1), RARB(1), RARG(4), ROR1(3), RORA(4), RORC(1), RXRA(2), RXRB(8), RXRG(2)	24247961	108	77	98	23	10	22	12	41	23	0	0.104	1.000	1.000
395	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(1), AGTR1(2), COL4A1(8), COL4A2(6), COL4A3(3), COL4A4(9), COL4A5(9), COL4A6(6)	14520565	45	37	44	13	1	8	7	16	13	0	0.307	1.000	1.000
396	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(8), DUSP1(1), IKBKAP(5), IKBKB(4), MAP3K1(3), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TNFAIP3(1), TNFRSF1B(1), TRAF1(1), TRAF3(1)	13148977	38	30	38	9	0	12	7	11	8	0	0.419	1.000	1.000
397	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG5(5), ATG7(2), BECN1(2), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNG(3), INS(1), PIK3C3(2), PIK3R4(4), PRKAA1(4), ULK1(3), ULK2(5), ULK3(1)	12117981	51	40	50	12	1	13	4	23	10	0	0.401	1.000	1.000
398	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(2), GTF2B(3), GTF2E1(3), GTF2F1(1), NCOA1(5), NCOA2(5), NCOA3(10), NCOR2(14), POLR2A(7), RARA(1), RXRA(2), TBP(1)	14264377	57	46	54	15	6	12	8	13	18	0	0.308	1.000	1.000
399	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	94	ANK2(15), B3GALT4(1), CDR1(1), DGKI(5), IL6ST(12), MRPL19(1), RPL11(3), RPL13(2), RPL18(1), RPL18A(3), RPL19(1), RPL21(1), RPL22(1), RPL23(1), RPL27(1), RPL28(1), RPL3(3), RPL35A(1), RPL37(1), RPL4(1), RPL5(1), RPL7A(3), RPL8(1), RPL9(1), RPLP0(1), RPS10(1), RPS13(1), RPS2(1), RPS23(1), RPS27(1), RPS27A(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS6(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), RPS6KA6(8), RPS6KB1(2), RPS6KB2(4), RPS7(1), RPS9(1), SLC36A2(3), TSPAN9(1), UBA52(1), UBC(1)	29371759	119	87	116	20	9	25	12	37	36	0	0.0172	1.000	1.000
400	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(12), CDH1(7), CREBBP(6), EP300(11), MAP3K7(3), SKIL(1), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1)	14442911	49	43	47	12	1	13	3	19	12	1	0.360	1.000	1.000
401	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(2), AKT2(3), AKT3(2), CDC42(3), CDKN1B(5), CDKN2A(11), CREB1(1), CREB5(2), ERBB4(11), GAB1(3), GSK3A(1), GSK3B(3), IFI27(2), INPPL1(1), IRS1(3), IRS2(2), IRS4(7), MET(2), MYC(2), NOLC1(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PARD3(3), PDK1(1), PIK3CA(13), PIK3CD(5), PPP1R13B(4), PREX1(16), PTEN(11), PTK2(9), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), RPS6KB1(2), SHC1(3), SLC2A4(2), SOS1(8), SOS2(4), TSC1(8), TSC2(12), YWHAE(1), YWHAZ(1)	43369363	214	134	203	36	17	43	23	74	56	1	0.000529	1.000	1.000
402	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(8), FADD(1), IKBKB(4), IL1R1(4), IRAK1(5), MAP3K1(3), MAP3K7(3), MYD88(1), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TLR4(5), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2)	14286427	53	41	53	12	0	18	7	19	9	0	0.259	1.000	1.000
403	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(11), BST1(1), CD38(3), ENPP1(1), ENPP3(4), NADK(3), NMNAT1(2), NMNAT3(1), NNT(4), NT5C1B(3), NT5C2(1), NT5E(1), NT5M(2), NUDT12(3)	12171927	40	33	39	10	0	16	6	10	7	1	0.298	1.000	1.000
404	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), CMBL(2), CYP3A4(1), CYP3A43(1), CYP3A5(4), DHRS1(1), DHRS3(1), DHRS7(1), PON1(1), PON2(1), PON3(3)	10405360	35	32	35	10	1	6	4	16	8	0	0.660	1.000	1.000
405	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	ACTA1(1), AGT(1), AKT1(2), CALR(4), CAMK1(1), CAMK1G(2), CREBBP(6), CSNK1A1(2), EDN1(2), ELSPBP1(2), F2(2), GSK3B(3), HAND1(2), HAND2(2), LIF(1), MAPK1(3), MAPK14(3), MAPK8(1), MEF2C(1), MYH2(7), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NKX2-5(1), PIK3CA(13), PIK3R1(4), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RAF1(2), RPS6KB1(2), SYT1(2)	28649599	104	76	97	22	7	28	11	38	20	0	0.0661	1.000	1.000
406	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	FYN(1), LRP8(3), RELN(12), VLDLR(2)	7810921	18	18	18	9	1	5	4	6	2	0	0.898	1.000	1.000
407	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(8), COL4A2(6), COL4A3(3), COL4A4(9), COL4A5(9), COL4A6(6), F10(3), F11(1), F12(1), F2(2), F2R(1), F5(7), F8(5), FGA(12), FGB(3), KLKB1(3), PROC(2), SERPINC1(2), SERPING1(3)	25380265	86	70	84	20	2	21	15	28	20	0	0.0697	1.000	1.000
408	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), CASP9(1), CDC42(3), CHUK(8), NFKB1(3), PIK3CA(13), PIK3R1(4), RAF1(2), RALA(2), RALBP1(1), RALGDS(1), RELA(4)	11076588	44	38	39	12	3	9	9	13	10	0	0.451	1.000	1.000
409	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CFL1(1), CHN1(1), LIMK1(4), MAP3K1(3), MYLK(3), NCF2(1), PAK1(3), PDGFRA(5), PIK3CA(13), PIK3R1(4), PLD1(4), PPP1R12B(4), RALBP1(1), RPS6KB1(2), TRIO(6), VAV1(3), WASF1(1)	19772018	61	49	55	13	5	14	6	26	10	0	0.191	1.000	1.000
410	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), AOX1(11), DCT(3), DDC(2), ECH1(1), ESCO1(2), ESCO2(3), GSTZ1(2), HEMK1(3), HGD(4), HPD(2), LCMT2(3), MAOA(1), MAOB(8), METTL2B(5), METTL6(3), NAT6(1), PNPLA3(1), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), SH3GLB1(2), TAT(3), TH(1), TPO(13), TYR(5), WBSCR22(2)	33422580	113	87	113	22	8	28	14	37	25	1	0.0245	1.000	1.000
411	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ACADL(2), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), AOC2(2), AOC3(1), DPYD(6), DPYS(1), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADHA(3), SDS(2), SMS(1), UPB1(1)	16317750	49	35	49	12	3	10	6	20	10	0	0.303	1.000	1.000
412	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1B(1), ADRA1D(4), ADRA2C(1), ADRB2(3), ADRB3(1), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), DRD1(1), DRD2(4), DRD3(2), DRD5(1), HRH1(2), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(3), HTR1F(1), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5)	14507373	58	49	56	16	8	8	4	29	9	0	0.313	1.000	1.000
413	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(10), ACAT1(2), ACAT2(5), ACYP1(1), ADH5(2), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), DLD(4), GLO1(2), HAGH(1), HAGHL(4), LDHA(1), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(1), ME2(3), ME3(1), PC(3), PCK1(6), PDHA1(1), PDHA2(3), PDHB(2), PKLR(3)	20729821	68	53	68	17	6	15	6	21	19	1	0.355	1.000	1.000
414	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(3), AGXT2(1), AOC2(2), AOC3(1), ATP6V0C(2), CBS(3), CHDH(4), CHKA(1), CPT1B(4), CTH(2), DAO(7), DLD(4), DMGDH(1), GAMT(1), GARS(1), GATM(4), GCAT(3), GLDC(3), MAOA(1), MAOB(8), PLCB2(3), PLCG1(7), PLCG2(7), SARDH(3), SHMT1(2), SHMT2(4), TARS(2)	24199821	84	59	83	15	6	26	6	23	23	0	0.0406	1.000	1.000
415	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(1), CD97(5), CRHR1(5), CRHR2(3), ELTD1(8), EMR1(6), EMR2(1), GHRHR(1), GIPR(1), GLP1R(3), GLP2R(3), GPR64(2), LPHN1(5), LPHN2(3), LPHN3(12), SCTR(2), VIPR1(3), VIPR2(2)	15835387	68	54	66	17	4	10	12	28	14	0	0.302	1.000	1.000
416	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(2), BDKRB2(3), CAV1(1), CHRM1(3), CHRNA1(4), FLT1(4), FLT4(6), KDR(7), NOS3(9), PDE2A(1), PDE3A(8), PDE3B(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKG1(6), PRKG2(4), RYR2(42), SYT1(2)	23947197	113	91	110	29	10	21	12	43	26	1	0.233	1.000	1.000
417	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(2), AP2A1(1), AP2M1(2), ARF1(1), EEA1(5), GRASP(1), GSK3A(1), GSK3B(3), LYN(1), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PLCG1(7), PRKCZ(4), RPS6KB1(2)	13951933	35	28	33	9	3	11	1	9	11	0	0.630	1.000	1.000
418	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT2(1), B3GNT4(2), B3GNT5(1), B4GALT2(1), B4GALT3(2), FUT1(4), FUT3(2), FUT5(1), FUT7(2), FUT9(4), GCNT2(1), ST3GAL6(1)	9028344	23	19	23	8	3	1	3	13	3	0	0.706	1.000	1.000
419	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), DHRS1(1), DHRS3(1), DHRS7(1), ESCO1(2), ESCO2(3), NAT6(1), PNPLA3(1), SH3GLB1(2)	13836182	28	25	28	9	1	5	3	11	8	0	0.728	1.000	1.000
420	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(8), COL4A2(6), COL4A3(3), COL4A4(9), COL4A5(9), COL4A6(6), P4HB(1), SLC23A1(1), SLC23A2(3), SLC2A3(2)	14617073	48	39	46	16	1	9	6	20	12	0	0.449	1.000	1.000
421	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(8), FOS(1), IKBKB(4), IRAK1(5), JUN(2), LY96(1), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP3K1(3), MAP3K7(3), MAPK14(3), MAPK8(1), MYD88(1), NFKB1(3), NFKBIA(2), PPARA(3), RELA(4), TIRAP(2), TLR10(3), TLR2(1), TLR3(5), TLR4(5), TLR6(4), TLR7(4), TLR9(3), TRAF6(2)	21035369	81	59	81	17	1	20	12	28	20	0	0.213	1.000	1.000
422	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(3), AKT1(2), AKT2(3), AKT3(2), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(5), PITX2(1), PLD1(4), PLD2(3), PLD3(4), VN1R1(1)	26503373	84	62	82	15	8	21	5	32	18	0	0.107	1.000	1.000
423	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG1(1), ARG2(1), ASL(1), ASS1(3), CKB(1), CKM(2), CKMT1B(1), CKMT2(2), CPS1(12), DAO(7), EPRS(4), GAMT(1), GATM(4), GLUD1(3), GLUD2(5), LAP3(3), NOS1(14), NOS3(9), OAT(2), P4HA1(2), P4HA2(1), P4HA3(1), PARS2(1), PRODH(1), PYCR1(1), RARS(3), RARS2(1)	21099059	88	68	87	22	6	22	11	27	22	0	0.259	1.000	1.000
424	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(3), AGXT2(1), AOC2(2), AOC3(1), CBS(3), CHDH(4), CHKA(1), CTH(2), DAO(7), DLD(4), DMGDH(1), GAMT(1), GARS(1), GATM(4), GCAT(3), GLDC(3), GNMT(2), HSD3B7(1), MAOA(1), MAOB(8), PHGDH(3), PSAT1(2), RDH11(1), RDH13(1), RDH14(1), SARDH(3), SARS2(2), SDS(2), SHMT1(2), SHMT2(4), TARS(2), TARS2(4)	24639929	80	56	80	17	8	24	5	21	22	0	0.136	1.000	1.000
425	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(1), CP(6), CPOX(1), EPRS(4), FECH(1), GUSB(8), HCCS(2), HMBS(4), HMOX1(1), PPOX(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5)	15196837	51	39	50	13	1	9	1	16	24	0	0.779	1.000	1.000
426	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(3), B4GALT5(1), C1GALT1(1), C1GALT1C1(1), GALNT1(2), GALNT10(1), GALNT11(1), GALNT12(5), GALNT13(4), GALNT14(3), GALNT3(2), GALNT4(4), GALNT5(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL5(4), GCNT3(2), GCNT4(1), OGT(3), ST3GAL1(1), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(7)	18318657	54	44	53	13	9	7	8	19	11	0	0.259	1.000	1.000
427	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH4A1(1), ALDH9A1(1), AOC2(2), AOC3(1), ARG1(1), ARG2(1), ASL(1), CKB(1), CKM(2), CKMT1B(1), CKMT2(2), CPS1(12), DAO(7), GAMT(1), GATM(4), GLUD1(3), MAOA(1), MAOB(8), NOS1(14), NOS3(9), OAT(2), ODC1(3), P4HA1(2), P4HA2(1), P4HA3(1), P4HB(1), PYCR1(1), RARS(3), SMS(1)	25633051	96	71	95	19	7	21	8	36	24	0	0.0723	1.000	1.000
428	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(3), CA1(1), CA14(1), CA4(2), CA5A(1), CA5B(1), CA6(1), CA8(1), CA9(7), CPS1(12), CTH(2), GLS(4), GLS2(1), GLUD1(3), GLUL(1)	10627182	41	36	41	12	3	11	8	11	8	0	0.446	1.000	1.000
429	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(10), ATP4A(7), ATP5A1(4), ATP5B(4), ATP5C1(1), ATP5F1(1), ATP5G2(1), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(2), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), COX10(1), COX4I2(1), COX5A(2), COX5B(2), COX6B1(2), CYC1(3), LHPP(1), NDUFA10(1), NDUFA2(1), NDUFA5(2), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB10(1), NDUFB3(1), NDUFB5(1), NDUFB6(1), NDUFB7(2), NDUFS1(2), NDUFS2(2), NDUFS3(1), NDUFS4(1), NDUFS6(1), NDUFV2(2), PPA1(1), SDHA(2), SDHB(1), UQCRB(1)	32178416	98	79	97	21	3	32	11	32	20	0	0.0867	1.000	1.000
430	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(8), CREBBP(6), DUSP1(1), EP300(11), IKBKB(4), IL1B(1), MAP2K3(2), MAP2K6(2), MAP3K7(3), MAPK11(1), MAPK14(3), MYD88(1), NFKB1(3), NFKBIA(2), NR3C1(3), RELA(4), TGFBR1(1), TGFBR2(1), TLR2(1), TNF(1)	16745862	59	48	58	15	1	14	7	23	14	0	0.482	1.000	1.000
431	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12B(3), ALOX15B(4), ALOX5(3), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2E1(4), CYP2U1(3), CYP4A11(3), CYP4A22(5), CYP4F2(1), CYP4F3(2), DHRS4(1), EPHX2(1), GGT1(1), GPX7(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(3)	22720676	77	64	75	18	10	16	6	23	22	0	0.202	1.000	1.000
432	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), GOSR1(1), GOSR2(2), SNAP25(3), SNAP29(1), STX10(3), STX12(2), STX16(2), STX18(1), STX19(2), STX2(2), STX5(1), STX6(2), STX8(1), TSNARE1(6), USE1(1), VAMP1(3), VAMP3(1), VTI1A(2), YKT6(2)	9590566	39	33	38	11	2	9	6	13	8	1	0.485	1.000	1.000
433	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(8), IFNB1(2), IKBKB(4), IL1B(1), IL1R1(4), IL1RAP(1), IL6(2), IRAK1(5), IRAK3(3), JUN(2), MAP2K3(2), MAP2K6(2), MAP3K1(3), MAP3K7(3), MAPK14(3), MAPK8(1), MYD88(1), NFKB1(3), NFKBIA(2), RELA(4), TGFB1(1), TGFB2(4), TGFB3(2), TNF(1), TRAF6(2)	16759493	66	54	66	17	2	17	9	23	15	0	0.416	1.000	1.000
434	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(2), INPP4A(1), INPP4B(6), INPP5A(3), INPPL1(1), ITPKA(1), ITPKB(4), MIOX(1), OCRL(4), PIK3C2A(4), PIK3C2B(8), PIK3C2G(7), PIK3CA(13), PIK3CB(5), PIK3CG(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCG1(7), PLCG2(7)	25769190	103	75	94	23	6	25	13	32	27	0	0.152	1.000	1.000
435	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), DCXR(1), GUSB(8), UGDH(2), UGP2(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5), XYLB(1)	14332604	43	32	41	12	0	8	1	13	21	0	0.917	1.000	1.000
436	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(6), GABBR1(7), GPRC5A(1), GPRC5C(1), GRM1(4), GRM2(2), GRM3(4), GRM4(4), GRM5(5), GRM7(3), GRM8(7)	11662443	44	37	44	13	6	8	4	20	6	0	0.407	1.000	1.000
437	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), AMDHD1(2), AOC2(2), AOC3(1), DDC(2), FTCD(3), HARS(1), HARS2(1), HDC(4), HEMK1(3), LCMT2(3), MAOA(1), MAOB(8), METTL2B(5), METTL6(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), PRPS1(1), UROC1(3), WBSCR22(2)	22537379	66	50	66	14	6	16	6	22	15	1	0.186	1.000	1.000
438	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(4), DLD(4), DLST(1), FH(3), IDH2(4), IDH3G(2), MDH1(1), OGDH(1), PC(3), PDHA1(1), PDHA2(3), PDHB(2), PDHX(3), PDK1(1), PDK2(1), PDK3(1), PDK4(2), SDHA(2), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1)	16140321	47	40	46	13	3	8	7	13	16	0	0.432	1.000	1.000
439	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3G(1), CD4(1), CREBBP(6), CSK(1), GNAS(10), GNB1(2), HLA-DRA(1), HLA-DRB1(1), LCK(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTPRC(8), ZAP70(3)	13162957	51	39	48	13	6	12	4	21	8	0	0.499	1.000	1.000
440	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3G(1), CD4(1), CREBBP(6), CSK(1), GNAS(10), GNB1(2), HLA-DRA(1), HLA-DRB1(1), LCK(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTPRC(8), ZAP70(3)	13162957	51	39	48	13	6	12	4	21	8	0	0.499	1.000	1.000
441	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(2), ACADM(1), ACOX1(2), ACOX2(3), ACOX3(1), ACSL1(1), ACSL3(2), ACSL5(1), ACSL6(3), ADIPOQ(3), ANGPTL4(2), APOA1(2), APOA2(1), APOA5(1), CD36(3), CPT1A(4), CPT1B(4), CPT2(1), CYP27A1(4), CYP4A11(3), CYP4A22(5), CYP7A1(1), CYP8B1(4), EHHADH(10), FABP1(1), FABP2(1), FABP7(1), GK(1), GK2(1), HMGCS2(2), LPL(1), ME1(1), MMP1(2), NR1H3(4), PCK1(6), PCK2(1), PDPK1(1), PLTP(4), PPARA(3), PPARG(1), RXRA(2), RXRB(8), RXRG(2), SCD(2), SCP2(3), SLC27A1(1), SLC27A4(1), SLC27A5(3), SLC27A6(2), SORBS1(1), UBC(1), UCP1(4)	37014167	125	91	123	29	11	17	21	45	30	1	0.114	1.000	1.000
442	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(1), CD5(1), CD7(1), IFNB1(2), IFNG(3), IL10(1), IL12A(6), IL12B(2), IL4(1), IL5(1), ITGAX(2), TLR2(1), TLR4(5), TLR7(4), TLR9(3)	10414269	37	32	37	11	0	7	6	19	5	0	0.497	1.000	1.000
443	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(2), CD3G(1), CXCR3(3), ETV5(2), IFNG(3), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL18(2), IL18R1(2), JAK2(4), JUN(2), MAP2K6(2), MAPK14(3), MAPK8(1), STAT4(4), TYK2(1)	10604960	48	41	48	14	3	9	8	17	11	0	0.471	1.000	1.000
444	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ACAT1(2), ACAT2(5), ACMSD(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), AOC2(2), AOC3(1), AOX1(11), CAT(1), CYP19A1(1), CYP1A1(3), CYP2A13(2), CYP2A6(3), CYP2A7(4), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2D6(1), CYP2E1(4), CYP2F1(1), CYP3A4(1), CYP3A5(4), CYP4B1(6), DDC(2), ECHS1(2), EHHADH(10), GCDH(1), HAAO(1), HADHA(3), KMO(1), KYNU(3), MAOA(1), MAOB(8), SDS(2), TPH1(2), WARS(2), WARS2(1)	30965580	114	82	114	27	3	31	11	36	33	0	0.174	1.000	1.000
445	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(9), BCL2(1), BIRC2(4), BIRC3(1), CASP10(2), CASP3(3), CASP6(2), CASP8(1), CASP9(1), CFLAR(2), CHUK(8), DFFB(1), FADD(1), GAS2(1), LMNA(2), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), SPTAN1(7), TNFRSF10B(2), TNFRSF25(2), TNFSF10(1)	18994906	64	50	64	16	2	21	6	14	21	0	0.442	1.000	1.000
446	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), BIRC2(4), BIRC3(1), CASP3(3), CASP8(1), CFLAR(2), FADD(1), JUN(2), MAP2K4(4), MAP3K3(1), MAP3K7(3), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), NR2C2(2), RALBP1(1), RIPK1(4), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1)	16319588	42	38	42	11	1	13	5	10	13	0	0.618	1.000	1.000
447	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC11(1), ANAPC2(5), ANAPC4(1), ANAPC5(1), ANAPC7(4), BTRC(5), CDC16(1), CDC23(1), CDC27(15), CUL1(2), CUL2(3), CUL3(2), FBXW11(1), FBXW7(3), FZR1(6), ITCH(1), SKP2(1), SMURF1(4), SMURF2(1), UBA1(3), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2D3(4), UBE2E1(1), UBE2E2(1), WWP1(3), WWP2(1)	23338525	78	54	71	18	6	22	6	14	30	0	0.242	1.000	1.000
448	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(6), ACO2(3), CLYBL(1), CS(4), DLD(4), DLST(1), FH(3), IDH1(8), IDH2(4), IDH3G(2), MDH1(1), OGDH(1), OGDHL(3), PC(3), PCK1(6), PCK2(1), SDHA(2), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1)	16734541	61	52	57	18	6	8	11	17	18	1	0.549	1.000	1.000
449	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(3), AKT3(2), ASAH1(2), DAG1(1), DRD2(4), EGFR(6), EPHB2(4), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), KCNJ3(3), MAPK1(3), PIK3CB(5), PITX2(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), RAF1(2), RGS20(1), SHC1(3), SOS1(8), SOS2(4), SRC(3), STAT3(4), TERF2IP(1)	33391631	128	93	123	27	11	32	9	49	26	1	0.152	1.000	1.000
450	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(2), AOC3(1), CES1(3), DDHD1(2), ESCO1(2), ESCO2(3), LIPA(1), NAT6(1), PLA1A(2), PNPLA3(1), PRDX6(1), SH3GLB1(2)	14222637	22	19	22	9	2	5	3	9	3	0	0.660	1.000	1.000
451	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(8), AP2A1(1), AP2M1(2), BIN1(4), EPN1(3), EPS15(1), NME1(2), NME2(1), PICALM(1), PPP3CA(3), PPP3CB(3), SYNJ1(7), SYNJ2(3), SYT1(2)	12955306	41	36	40	13	5	8	4	13	11	0	0.622	1.000	1.000
452	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(3), ALDH4A1(1), ALDH5A1(1), CAD(4), CPS1(12), EPRS(4), GAD1(5), GAD2(1), GCLC(1), GCLM(1), GFPT1(1), GFPT2(2), GLS(4), GLS2(1), GLUD1(3), GLUD2(5), GLUL(1), GMPS(4), GNPNAT1(1), GPT(1), GPT2(2), GSR(3), GSS(1), NAGK(3), PPAT(4), QARS(1)	22347634	70	47	69	17	2	21	9	18	20	0	0.217	1.000	1.000
453	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(10), ACADL(2), ACADM(1), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH9A1(1), ECHS1(2), EHHADH(10), HADHA(3), LDHA(1), LDHB(1), LDHC(1), MUT(4), PCCA(1), PCCB(1), SDS(2), SUCLA2(2), SUCLG1(1), SUCLG2(1)	18698676	62	44	62	17	1	15	6	19	21	0	0.485	1.000	1.000
454	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(1), ALDH18A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC2(2), AOC3(1), ARG1(1), ARG2(1), ASL(1), ASS1(3), CPS1(12), GATM(4), MAOA(1), MAOB(8), NAGS(1), ODC1(3), SMS(1), SRM(2)	16706548	50	40	49	13	2	11	5	18	14	0	0.341	1.000	1.000
455	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	AZIN1(3), BTG1(1), CBX3(2), CLDN5(1), CLOCK(1), CRY1(1), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(4), ETV6(1), GFRA1(2), GSTM3(1), GSTP1(2), HSPA8(2), IDI1(1), KLF9(3), MYF6(1), NCKAP1(3), NCOA4(2), NR1D2(1), PER1(6), PER2(4), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(3), TOB1(4), TUBB3(1), UGP2(3), VAPA(1), ZFR(2)	20739295	63	53	61	15	5	16	7	21	13	1	0.270	1.000	1.000
456	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(10), ACACB(10), ACADM(1), ACAT1(2), ACAT2(5), ACSS1(2), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH7A1(1), ALDH9A1(1), ECHS1(2), EHHADH(10), HADHA(3), HIBCH(6), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), MUT(4), PCCA(1), PCCB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1)	22375656	80	57	79	22	2	21	9	27	21	0	0.345	1.000	1.000
457	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(5), ACOT11(1), ACYP1(1), DHRS1(1), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(10), ESCO1(2), ESCO2(3), FN3K(1), GCDH(1), HADHA(3), NAT6(1), PNPLA3(1), SH3GLB1(2)	14465877	38	28	38	11	1	8	6	16	7	0	0.456	1.000	1.000
458	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(3), ALG11(1), ALG13(1), ALG14(1), ALG2(1), ALG5(3), ALG6(1), ALG8(1), ALG9(1), B4GALT2(1), B4GALT3(2), DDOST(1), DOLPP1(1), DPM1(1), FUT8(2), GANAB(3), MAN1A1(3), MAN1A2(3), MAN1B1(1), MAN1C1(1), MAN2A1(8), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), MGAT5B(3), RFT1(2), RPN1(1), RPN2(2), ST6GAL1(1), STT3B(4)	24422455	69	47	69	15	3	22	6	24	13	1	0.158	1.000	1.000
459	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(5), CCNB1(2), CDC25C(3), GNAI1(4), GNAS(10), GNB1(2), MAPK1(3), MYT1(2), PIN1(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RPS6KA1(1), SRC(3)	11883513	46	39	42	13	7	12	4	16	7	0	0.535	1.000	1.000
460	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(3), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH5A1(1), ALDH9A1(1), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADHA(3), HMGCL(2), L2HGDH(2), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(2), SDHB(1), SDS(2)	14579310	57	44	56	18	2	12	7	25	11	0	0.630	1.000	1.000
461	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(2), GTF2A1L(1), GTF2B(3), GTF2E1(3), GTF2F1(1), GTF2H4(3), GTF2I(2), GTF2IRD1(1), STON1(6), TAF1(8), TAF10(1), TAF1L(6), TAF2(5), TAF4(1), TAF4B(4), TAF6(4), TAF6L(1), TAF7L(2), TAF9B(3), TBPL1(2), TBPL2(1)	20973990	60	49	58	15	3	20	8	16	11	2	0.193	1.000	1.000
462	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	26	BRCA1(9), CCND1(1), CREBBP(6), EP300(11), ERCC3(3), ESR1(6), GRIP1(6), GTF2A1(2), GTF2E1(3), GTF2F1(1), HDAC2(3), HDAC4(7), HDAC5(4), HDAC6(7), MEF2C(1), NCOR2(14), NR0B1(3), NRIP1(1), PELP1(5), POLR2A(7), TBP(1)	27171547	101	76	97	28	9	27	12	30	21	2	0.222	1.000	1.000
463	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(9), BAX(3), BCL2(1), CASP10(2), CASP3(3), CASP4(3), CASP6(2), CASP8(1), CASP9(1), CD40(3), CRADD(1), DAXX(1), DFFB(1), FADD(1), FAS(3), IKBKE(1), MCL1(2), NFKB1(3), NFKBIA(2), NGFR(3), NR3C1(3), NTRK1(5), PTPN13(14), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF3(1), TRAF6(2)	24864870	79	66	78	21	5	27	7	21	19	0	0.360	1.000	1.000
464	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA2(1), ACADM(1), ACAT1(2), ACAT2(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH7A1(1), ALDH9A1(1), AOX1(11), BCAT1(2), BCAT2(1), BCKDHA(1), DBT(2), DLD(4), ECHS1(2), EHHADH(10), HADH(1), HADHA(3), HADHB(4), HIBADH(1), HIBCH(6), HMGCL(2), HMGCS1(2), HMGCS2(2), HSD17B4(1), IVD(1), MCCC1(5), MCCC2(2), MUT(4), OXCT1(2), PCCA(1), PCCB(1)	24812374	91	56	89	26	2	28	9	30	22	0	0.373	1.000	1.000
465	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), CEBPA(5), CHUK(8), DAXX(1), EGF(6), EGFR(6), ETS1(2), ETS2(1), FOS(1), HOXA7(2), IKBKB(4), JUN(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K5(1), MAPK1(3), MAPK14(3), MAPK8(1), NFKB1(3), NFKBIA(2), PPP2CA(2), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), RAF1(2), RELA(4), RIPK1(4), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1)	26977015	95	73	92	25	1	20	13	37	24	0	0.595	1.000	1.000
466	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), CDC42(3), CREB1(1), CREB5(2), DUSP1(1), EEF2K(1), HSPB1(1), IL1R1(4), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP3K10(1), MAP3K4(9), MAP3K5(1), MAP3K7(3), MAPK1(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MKNK1(2), MKNK2(3), MYEF2(3), NFKB1(3), NR2C2(2), SRF(1), TRAF6(2)	19528172	65	55	65	19	8	17	9	14	16	1	0.474	1.000	1.000
467	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	248	ACVR1B(2), ACVR1C(1), AKT1(2), AKT2(3), AKT3(2), ARRB1(2), ARRB2(1), ATF2(1), ATF4(4), BDNF(1), CACNA1A(9), CACNA1B(13), CACNA1C(9), CACNA1D(6), CACNA1E(33), CACNA1F(3), CACNA1G(9), CACNA1H(7), CACNA1I(6), CACNA1S(6), CACNA2D1(10), CACNA2D2(6), CACNA2D3(5), CACNA2D4(5), CACNB1(2), CACNB2(1), CACNB4(5), CACNG2(4), CACNG3(2), CACNG4(2), CACNG5(1), CACNG6(1), CACNG7(2), CACNG8(2), CASP3(3), CDC25B(2), CDC42(3), CHUK(8), DAXX(1), DUSP1(1), DUSP14(1), DUSP16(1), DUSP4(1), DUSP5(1), DUSP6(2), DUSP7(1), DUSP8(2), DUSP9(1), ECSIT(2), EGF(6), EGFR(6), FAS(3), FGF12(1), FGF14(1), FGF20(3), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGF9(1), FGFR1(2), FGFR2(4), FGFR3(3), FGFR4(6), FLNA(4), FLNB(10), FLNC(5), FOS(1), GADD45G(1), GNA12(1), GNG12(1), IKBKB(4), IL1B(1), IL1R1(4), IL1R2(1), JUN(2), JUND(1), KRAS(6), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K5(1), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(2), MAP3K13(4), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAP3K5(1), MAP3K6(1), MAP3K7(3), MAP3K8(1), MAP4K1(1), MAP4K2(4), MAP4K3(1), MAP4K4(4), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK7(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(3), MAPT(6), MEF2C(1), MKNK1(2), MKNK2(3), MOS(2), MYC(2), NF1(14), NFATC2(7), NFATC4(5), NFKB1(3), NFKB2(2), NLK(2), NR4A1(3), NRAS(3), NTF3(1), NTRK1(5), NTRK2(6), PAK1(3), PAK2(3), PDGFA(2), PDGFB(1), PDGFRA(5), PDGFRB(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PPM1B(1), PPP3CA(3), PPP3CB(3), PPP5C(4), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), PTPN5(4), PTPRR(2), RAC3(1), RAF1(2), RAP1A(2), RAPGEF2(7), RASA1(10), RASA2(2), RASGRF1(6), RASGRF2(5), RASGRP1(5), RASGRP3(1), RASGRP4(3), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), RPS6KA4(2), RPS6KA5(5), RPS6KA6(8), SOS1(8), SOS2(4), SRF(1), STK3(6), STK4(1), STMN1(1), TAOK1(5), TAOK2(4), TAOK3(4), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF1A(1), TP53(117), TRAF6(2), ZAK(3)	170175165	749	282	704	175	70	148	81	250	197	3	0.000610	1.000	1.000
468	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTG1(1), ACTN1(4), ACTN2(6), ACTN4(2), AKT1(2), AKT2(3), AKT3(2), ARHGAP5(3), BCAR1(3), BCL2(1), BIRC2(4), BIRC3(1), CAPN2(1), CAV1(1), CAV2(1), CCND1(1), CCND2(3), CDC42(3), COL11A1(21), COL11A2(10), COL1A1(6), COL1A2(8), COL2A1(9), COL3A1(8), COL4A1(8), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(14), COL5A2(5), COL5A3(9), COL6A1(6), COL6A2(4), COL6A3(18), COL6A6(16), COMP(5), CTNNB1(102), DIAPH1(5), DOCK1(7), EGF(6), EGFR(6), ERBB2(4), FARP2(4), FIGF(1), FLNA(4), FLNB(10), FLNC(5), FLT1(4), FN1(13), FYN(1), GSK3B(3), HGF(7), IBSP(2), IGF1R(11), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAV(3), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), JUN(2), KDR(7), LAMA1(17), LAMA2(13), LAMA3(14), LAMA4(3), LAMA5(13), LAMB1(5), LAMB2(8), LAMB3(6), LAMB4(7), LAMC1(6), LAMC2(6), LAMC3(3), MAPK1(3), MAPK10(3), MAPK8(1), MAPK9(3), MET(2), MYLK(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PARVA(1), PARVB(1), PDGFA(2), PDGFB(1), PDGFC(3), PDGFD(3), PDGFRA(5), PDGFRB(1), PDPK1(1), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PPP1CA(2), PPP1CC(1), PPP1R12A(2), PRKCA(1), PRKCG(4), PTEN(11), PTK2(9), PXN(2), RAC3(1), RAF1(2), RAP1A(2), RAPGEF1(8), RELN(12), ROCK1(6), ROCK2(3), SHC1(3), SHC4(4), SOS1(8), SOS2(4), SRC(3), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TLN1(10), TLN2(9), TNC(7), TNN(8), TNR(11), TNXB(12), VASP(2), VAV1(3), VAV3(8), VCL(3), VEGFA(1), VEGFC(6), VTN(1), VWF(7), ZYX(2)	213969325	895	281	807	214	53	205	101	324	204	8	0.000957	1.000	1.000
469	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	169	ADCY1(5), ADCY2(14), ADCY3(2), ADCY4(4), ADCY7(1), ADCY8(9), ADCY9(6), ADORA2A(2), ADORA2B(1), ADRA1B(1), ADRA1D(4), ADRB2(3), ADRB3(1), AGTR1(2), ATP2A1(1), ATP2A2(7), ATP2A3(2), ATP2B1(5), ATP2B2(10), ATP2B3(4), ATP2B4(3), AVPR1A(3), AVPR1B(2), BDKRB2(3), BST1(1), CACNA1A(9), CACNA1B(13), CACNA1C(9), CACNA1D(6), CACNA1E(33), CACNA1F(3), CACNA1G(9), CACNA1H(7), CACNA1I(6), CACNA1S(6), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CCKAR(1), CCKBR(3), CD38(3), CHRM1(3), CHRM2(5), CHRM3(7), CHRM5(2), CHRNA7(1), CYSLTR1(2), CYSLTR2(3), DRD1(1), EDNRA(1), EDNRB(2), EGFR(6), ERBB2(4), ERBB3(8), ERBB4(11), F2R(1), GNA15(1), GNAL(2), GNAQ(1), GNAS(10), GRIN1(5), GRIN2A(6), GRIN2C(5), GRIN2D(2), GRM1(4), GRM5(5), GRPR(1), HRH1(2), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), LHCGR(6), MYLK(3), MYLK2(2), NOS1(14), NOS3(9), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(3), P2RX4(1), P2RX7(1), PDE1A(2), PDE1B(2), PDE1C(9), PDGFRA(5), PDGFRB(1), PHKA1(6), PHKA2(3), PHKB(8), PHKG2(2), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(7), PLCG2(7), PLCZ1(3), PPP3CA(3), PPP3CB(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), PTGER1(1), PTGER3(7), PTGFR(2), PTK2B(5), RYR1(31), RYR2(42), RYR3(21), SLC25A4(1), SLC25A5(1), SLC25A6(2), SLC8A1(6), SLC8A2(2), SLC8A3(1), SPHK1(7), SPHK2(3), TACR1(2), TACR2(2), TACR3(4), TNNC2(2), TRHR(3), TRPC1(5), VDAC1(2)	159438895	676	263	658	190	67	159	55	254	139	2	0.238	1.000	1.000
470	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	ACTG1(1), COL11A1(21), COL11A2(10), COL17A1(5), COL1A1(6), COL1A2(8), COL2A1(9), COL3A1(8), COL4A1(8), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(14), COL5A2(5), COL5A3(9), COL6A1(6), COL6A2(4), COL6A3(18), COL6A6(16), COMP(5), DES(3), DSC1(2), DSC2(4), DSC3(1), DSG1(1), DSG2(2), DSG3(5), DSG4(7), FN1(13), GJA1(1), GJA10(1), GJA4(1), GJA5(3), GJA8(6), GJB1(3), GJB2(1), GJB4(2), GJB5(1), GJB6(2), GJB7(1), GJC1(2), GJC2(2), GJD2(2), GJD4(2), IBSP(2), INA(1), ITGA6(3), ITGB4(9), KRT1(7), KRT10(11), KRT12(1), KRT13(2), KRT14(1), KRT15(3), KRT16(3), KRT17(2), KRT18(1), KRT19(1), KRT2(12), KRT20(5), KRT23(1), KRT24(3), KRT27(4), KRT28(2), KRT3(1), KRT31(3), KRT32(4), KRT33A(2), KRT33B(2), KRT34(5), KRT35(4), KRT36(2), KRT37(2), KRT38(5), KRT39(2), KRT4(1), KRT40(5), KRT5(4), KRT6A(3), KRT6B(2), KRT6C(2), KRT7(3), KRT71(3), KRT72(5), KRT73(2), KRT74(1), KRT75(3), KRT76(2), KRT77(1), KRT78(1), KRT79(5), KRT81(4), KRT83(3), KRT84(2), KRT85(3), KRT86(2), KRT9(3), LAMA1(17), LAMA2(13), LAMA3(14), LAMA4(3), LAMA5(13), LAMB1(5), LAMB2(8), LAMB3(6), LAMB4(7), LAMC1(6), LAMC2(6), LAMC3(3), LMNA(2), LMNB2(2), NES(8), RELN(12), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TNC(7), TNN(8), TNR(11), TNXB(12), VIM(4), VTN(1), VWF(7)	143825317	602	237	587	169	52	103	61	229	149	8	0.180	1.000	1.000
471	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTG1(1), ACTN1(4), ACTN2(6), ACTN4(2), AKT1(2), AKT2(3), AKT3(2), AMOTL1(3), ASH1L(11), CASK(2), CDC42(3), CGN(3), CLDN1(1), CLDN16(3), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(3), CLDN4(1), CLDN5(1), CLDN8(2), CLDN9(2), CRB3(1), CSNK2A1(2), CTNNA1(3), CTNNA2(10), CTNNA3(5), CTNNB1(102), CTTN(3), EPB41(1), EPB41L1(3), EPB41L2(2), EPB41L3(11), EXOC3(2), EXOC4(4), F11R(1), GNAI1(4), GNAI2(1), GNAI3(1), HCLS1(2), IGSF5(4), INADL(15), JAM2(3), JAM3(5), KRAS(6), LLGL1(1), LLGL2(2), MAGI1(1), MAGI2(6), MAGI3(4), MLLT4(3), MPDZ(8), MPP5(1), MYH1(8), MYH10(4), MYH11(5), MYH13(5), MYH14(12), MYH15(14), MYH2(7), MYH3(6), MYH4(11), MYH6(9), MYH7(13), MYH7B(5), MYH8(5), MYH9(3), NRAS(3), OCLN(3), PARD3(3), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), PPP2R3A(3), PPP2R3B(2), PPP2R4(5), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PTEN(11), SPTAN1(7), SRC(3), SYMPK(4), TJAP1(2), TJP1(6), TJP2(2), TJP3(1), VAPA(1), YES1(2), ZAK(3)	109704102	473	233	392	112	21	113	59	188	90	2	0.0319	1.000	1.000
472	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(2), ACTN1(4), ACTN2(6), ACTN4(2), APC(12), APC2(3), ARAF(5), ARHGEF1(1), ARHGEF12(8), ARHGEF4(4), ARHGEF6(3), ARHGEF7(4), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), ARPC5L(1), BAIAP2(1), BCAR1(3), BDKRB2(3), CDC42(3), CFL1(1), CFL2(2), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), CSK(1), CYFIP1(3), CYFIP2(5), DIAPH1(5), DIAPH2(2), DIAPH3(4), DOCK1(7), EGF(6), EGFR(6), EZR(1), F2(2), F2R(1), FGD1(1), FGD3(5), FGF12(1), FGF14(1), FGF20(3), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGF9(1), FGFR1(2), FGFR2(4), FGFR3(3), FGFR4(6), FN1(13), GIT1(2), GNA12(1), GNA13(1), GNG12(1), GSN(2), INS(1), IQGAP1(8), IQGAP2(5), IQGAP3(7), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAD(10), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(3), ITGAX(2), ITGB2(8), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), KRAS(6), LIMK1(4), LIMK2(1), MAP2K2(2), MAPK1(3), MOS(2), MSN(3), MYH10(4), MYH14(12), MYH9(3), MYLK(3), MYLK2(2), NCKAP1(3), NCKAP1L(4), NRAS(3), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PDGFA(2), PDGFB(1), PDGFRA(5), PDGFRB(1), PFN3(1), PFN4(1), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PIP4K2A(1), PIP4K2B(3), PIP4K2C(1), PIP5K1B(1), PPP1CA(2), PPP1CC(1), PPP1R12A(2), PPP1R12B(4), PTK2(9), PXN(2), RAC3(1), RAF1(2), RDX(1), ROCK1(6), ROCK2(3), SCIN(5), SLC9A1(6), SOS1(8), SOS2(4), SSH1(1), SSH2(3), SSH3(2), TIAM1(5), TIAM2(6), VAV1(3), VAV3(8), VCL(3), WASF1(1), WASF2(2), WASL(2)	160314788	558	231	544	154	47	138	57	197	117	2	0.196	1.000	1.000
473	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(2), ADORA1(1), ADORA2A(2), ADORA2B(1), ADORA3(2), ADRA1B(1), ADRA2B(1), ADRA2C(1), ADRB2(3), ADRB3(1), AGTR1(2), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB2(3), C3AR1(1), CALCR(1), CCKAR(1), CCKBR(3), CGA(1), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), CNR1(3), CNR2(1), CRHR1(5), CRHR2(3), CTSG(1), CYSLTR1(2), CYSLTR2(3), DRD1(1), DRD2(4), DRD3(2), DRD5(1), EDNRA(1), EDNRB(2), F2(2), F2R(1), F2RL3(1), FPR1(1), FSHR(4), GABBR1(7), GABBR2(3), GABRA1(5), GABRA2(7), GABRA3(1), GABRA4(6), GABRA5(4), GABRA6(7), GABRB1(4), GABRB2(2), GABRB3(3), GABRG1(10), GABRG2(4), GABRG3(3), GABRP(1), GABRQ(8), GABRR1(2), GABRR2(2), GALR2(1), GH1(1), GH2(3), GHR(3), GHRHR(1), GHSR(2), GIPR(1), GLP1R(3), GLP2R(3), GLRA1(2), GLRA2(2), GLRA3(1), GLRB(1), GPR156(4), GPR35(2), GPR50(2), GPR63(7), GPR83(4), GRIA1(10), GRIA2(9), GRIA3(6), GRIA4(11), GRID1(5), GRID2(4), GRIK1(5), GRIK2(7), GRIK3(4), GRIK4(4), GRIK5(2), GRIN1(5), GRIN2A(6), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRIN3A(6), GRIN3B(3), GRM1(4), GRM2(2), GRM3(4), GRM4(4), GRM5(5), GRM7(3), GRM8(7), GRPR(1), GZMA(3), HCRTR1(1), HCRTR2(2), HRH1(2), HRH3(2), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(3), HTR1F(1), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5), KISS1R(1), LEP(2), LEPR(4), LHB(2), LHCGR(6), LTB4R(1), MC2R(3), MC3R(2), MC4R(2), MC5R(1), MCHR1(1), MCHR2(1), MTNR1A(2), MTNR1B(3), NMBR(1), NMUR1(3), NMUR2(6), NPBWR2(3), NPFFR1(1), NPFFR2(4), NPY1R(3), NPY2R(4), NPY5R(5), NR3C1(3), NTSR2(3), OPRK1(3), OPRL1(2), OPRM1(4), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(3), P2RX4(1), P2RX7(1), P2RY1(4), P2RY10(3), P2RY11(2), P2RY13(1), P2RY14(1), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(3), PRL(3), PRLHR(2), PRLR(1), PRSS1(2), PRSS3(1), PTGER1(1), PTGER2(3), PTGER3(7), PTGER4(1), PTGFR(2), PTGIR(2), PTH2R(4), RXFP1(4), RXFP2(1), SCTR(2), SSTR2(1), SSTR3(5), SSTR4(3), SSTR5(3), TAAR1(1), TAAR2(3), TAAR5(1), TACR1(2), TACR2(2), TACR3(4), TRHR(3), TRPV1(2), TSHR(2), TSPO(1), UTS2R(1), VIPR1(3), VIPR2(2)	125699013	548	226	534	151	51	94	59	246	98	0	0.122	1.000	1.000
474	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	AGRN(3), CD36(3), CD44(4), CD47(2), COL11A1(21), COL11A2(10), COL1A1(6), COL1A2(8), COL2A1(9), COL3A1(8), COL4A1(8), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(14), COL5A2(5), COL5A3(9), COL6A1(6), COL6A2(4), COL6A3(18), COL6A6(16), DAG1(1), FN1(13), FNDC1(7), FNDC3A(3), FNDC5(1), GP1BB(1), GP6(3), HMMR(4), HSPG2(19), IBSP(2), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAV(3), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), LAMA1(17), LAMA2(13), LAMA3(14), LAMA4(3), LAMA5(13), LAMB1(5), LAMB2(8), LAMB3(6), LAMB4(7), LAMC1(6), LAMC2(6), LAMC3(3), RELN(12), SDC2(1), SDC3(1), SDC4(2), SV2A(1), SV2B(3), SV2C(1), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TNC(7), TNN(8), TNR(11), TNXB(12), VTN(1), VWF(7)	130554141	504	220	500	143	39	111	50	172	124	8	0.180	1.000	1.000
475	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(5), ADCY2(14), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ADRA1B(1), ADRA1D(4), ADRB2(3), ADRB3(1), ANXA6(1), ARRB1(2), ARRB2(1), ATP1A4(6), ATP1B3(1), ATP2A2(7), ATP2A3(2), ATP2B1(5), ATP2B2(10), ATP2B3(4), CACNA1A(9), CACNA1B(13), CACNA1C(9), CACNA1D(6), CACNA1E(33), CACNA1S(6), CACNB1(2), CALR(4), CAMK1(1), CAMK2A(6), CAMK2B(2), CAMK2G(3), CASQ1(1), CASQ2(1), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), GJA1(1), GJA4(1), GJA5(3), GJB1(3), GJB2(1), GJB4(2), GJB5(1), GJB6(2), GNAI2(1), GNAI3(1), GNAQ(1), GNAZ(2), GNB1(2), GNB2(3), GNB4(1), GNB5(4), GNG12(1), GNG4(1), ITPR1(15), ITPR2(11), ITPR3(11), KCNB1(2), KCNJ3(3), MIB1(4), NME7(1), PLCB3(4), PRKACA(2), PRKACB(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(1), RGS18(4), RGS2(1), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS6(2), RGS7(7), RGS9(1), RYR1(31), RYR2(42), RYR3(21), SLC8A1(6), SLC8A3(1), USP5(4)	109594880	456	217	445	108	47	94	41	182	91	1	0.0255	1.000	1.000
476	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(2), ABLIM1(3), ABLIM2(1), ABLIM3(1), ARHGEF12(8), CDC42(3), CFL1(1), CFL2(2), CXCL12(1), CXCR4(2), DCC(10), DPYSL2(2), DPYSL5(5), EFNA3(1), EFNA4(1), EFNA5(2), EFNB2(7), EPHA1(5), EPHA2(5), EPHA3(14), EPHA4(13), EPHA5(6), EPHA6(7), EPHA7(7), EPHA8(7), EPHB1(5), EPHB2(4), EPHB3(8), EPHB4(1), EPHB6(3), FES(1), FYN(1), GNAI1(4), GNAI2(1), GNAI3(1), GSK3B(3), KRAS(6), L1CAM(7), LIMK1(4), LIMK2(1), LRRC4C(4), MAPK1(3), MET(2), NCK1(1), NCK2(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NGEF(1), NRAS(3), NRP1(2), NTN1(2), NTN4(2), NTNG1(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PLXNA1(4), PLXNA2(7), PLXNA3(4), PLXNB1(4), PLXNB2(5), PLXNB3(8), PLXNC1(8), PPP3CA(3), PPP3CB(3), PTK2(9), RAC3(1), RASA1(10), RGS3(3), RND1(1), ROBO1(13), ROBO2(15), ROBO3(2), ROCK1(6), ROCK2(3), SEMA3A(10), SEMA3C(7), SEMA3D(7), SEMA3E(8), SEMA3F(2), SEMA3G(1), SEMA4A(1), SEMA4C(1), SEMA4D(3), SEMA4F(4), SEMA4G(1), SEMA5A(2), SEMA5B(7), SEMA6A(5), SEMA6B(2), SEMA6C(6), SEMA6D(13), SEMA7A(6), SLIT1(6), SLIT2(9), SLIT3(8), SRGAP1(3), SRGAP3(7), UNC5A(1), UNC5B(2), UNC5C(2), UNC5D(6)	113493498	475	214	466	137	43	99	56	181	94	2	0.377	1.000	1.000
477	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(5), ADCY2(14), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CREB1(1), CREB3L1(2), CREB3L2(2), CREB3L3(5), CREB3L4(3), CREBBP(6), CTNNB1(102), DCT(3), DVL1(3), DVL2(6), DVL3(1), EDN1(2), EDNRB(2), EP300(11), FZD1(2), FZD10(1), FZD2(4), FZD3(2), FZD4(2), FZD6(2), FZD7(3), FZD8(2), FZD9(3), GNAI1(4), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(10), GSK3B(3), KIT(12), KITLG(2), KRAS(6), LEF1(2), MAP2K2(2), MAPK1(3), MITF(1), NRAS(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), POMC(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), RAF1(2), TCF7(2), TCF7L1(3), TCF7L2(3), TYR(5), WNT1(2), WNT11(1), WNT2(3), WNT3A(2), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2)	62633132	359	199	274	70	19	98	38	132	71	1	0.000593	1.000	1.000
478	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA1(1), ACTA2(1), ADCY1(5), ADCY2(14), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ARRB1(2), ARRB2(1), ATF2(1), ATF3(3), ATF4(4), ATF5(1), ATP2A2(7), ATP2A3(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CNN1(1), CNN2(1), CORIN(5), CRH(1), CRHR1(5), DGKZ(2), ETS2(1), FOS(1), GABPB2(1), GBA2(1), GJA1(1), GNAQ(1), GNB1(2), GNB2(3), GNB4(1), GNB5(4), GNG12(1), GNG4(1), GSTO1(1), GUCA2B(1), GUCY1A3(4), IGFBP3(2), IGFBP4(1), IL1B(1), IL6(2), ITPR1(15), ITPR2(11), ITPR3(11), JUN(2), MIB1(4), MYLK2(2), NFKB1(3), NOS1(14), NOS3(9), OXTR(1), PDE4B(3), PDE4D(4), PLCB3(4), PLCD1(2), PLCG1(7), PLCG2(7), PRKACA(2), PRKACB(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(1), RGS18(4), RGS2(1), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS6(2), RGS7(7), RGS9(1), RLN1(2), RYR1(31), RYR2(42), RYR3(21), SLC8A1(6), SP1(2), TNXB(12), USP5(4)	100749488	400	196	391	92	33	77	40	156	92	2	0.0471	1.000	1.000
479	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(2), ACTG1(1), ACTN1(4), ACTN2(6), ACTN4(2), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDC42(3), CDH1(7), CREBBP(6), CSNK2A1(2), CTNNA1(3), CTNNA2(10), CTNNA3(5), CTNNB1(102), CTNND1(3), EGFR(6), EP300(11), ERBB2(4), FARP2(4), FER(2), FGFR1(2), FYN(1), IGF1R(11), INSR(4), IQGAP1(8), LEF1(2), LMO7(7), MAP3K7(3), MAPK1(3), MET(2), MLLT4(3), NLK(2), PARD3(3), PTPN6(2), PTPRB(14), PTPRJ(4), PTPRM(11), PVRL1(2), PVRL2(2), PVRL3(2), RAC3(1), SMAD2(1), SMAD3(3), SMAD4(5), SNAI1(2), SORBS1(1), SRC(3), SSX2IP(3), TCF7(2), TCF7L1(3), TCF7L2(3), TGFBR1(1), TGFBR2(1), TJP1(6), VCL(3), WASF1(1), WASF2(2), WASF3(2), WASL(2), YES1(2)	68133120	322	193	243	63	12	81	53	121	55	0	0.000220	1.000	1.000
480	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	252	ACVR1(2), ACVR1B(2), ACVR2A(13), ACVR2B(3), AMH(1), AMHR2(2), BMP2(2), BMP7(3), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL11(1), CCL13(1), CCL14(1), CCL15(1), CCL16(1), CCL18(1), CCL24(1), CCL25(1), CCL3(1), CCL8(1), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR6(5), CCR7(2), CCR8(1), CCR9(1), CD40(3), CD70(2), CLCF1(2), CNTFR(2), CRLF2(1), CSF1(2), CSF1R(1), CSF2RB(2), CSF3R(1), CX3CL1(2), CXCL1(1), CXCL12(1), CXCL13(1), CXCL14(2), CXCL5(1), CXCR3(3), CXCR4(2), EDA(2), EDA2R(2), EDAR(1), EGF(6), EGFR(6), EPOR(1), FAS(3), FLT1(4), FLT3(4), FLT3LG(2), FLT4(6), GDF5(2), GH1(1), GH2(3), GHR(3), HGF(7), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IFNG(3), IFNGR1(3), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(3), IL10RB(2), IL11RA(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL13RA1(2), IL17A(1), IL17RA(2), IL17RB(1), IL18(2), IL18R1(2), IL18RAP(6), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(1), IL20RA(3), IL21R(8), IL22(1), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL2RA(1), IL2RB(2), IL2RG(1), IL4(1), IL4R(1), IL5(1), IL5RA(1), IL6(2), IL6R(3), IL6ST(12), IL7(1), IL7R(1), IL9R(2), INHBA(3), INHBC(1), INHBE(2), KDR(7), KIT(12), KITLG(2), LEP(2), LEPR(4), LIF(1), LIFR(5), LTBR(1), MET(2), MPL(1), NGFR(3), OSMR(1), PDGFB(1), PDGFC(3), PDGFRA(5), PDGFRB(1), PF4(1), PF4V1(1), PPBP(1), PRL(3), PRLR(1), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10B(2), TNFRSF10D(2), TNFRSF11A(1), TNFRSF11B(4), TNFRSF14(1), TNFRSF18(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(1), TNFRSF8(3), TNFSF10(1), TNFSF11(1), TNFSF13B(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TNFSF4(1), TNFSF8(1), TPO(13), TSLP(1), VEGFA(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(1)	101335369	401	187	395	123	18	89	38	158	96	2	0.734	1.000	1.000
481	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(10), ACACB(10), AKT1(2), AKT2(3), AKT3(2), ARAF(5), CALML6(2), CBL(4), CBLB(3), CBLC(1), EXOC7(6), FASN(18), FBP1(1), FBP2(2), FLOT1(3), FOXO1(1), G6PC(3), GSK3B(3), GYS1(3), GYS2(5), IKBKB(4), INS(1), INSR(4), IRS1(3), IRS2(2), IRS4(7), KRAS(6), LIPE(1), MAP2K2(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK9(3), MKNK1(2), MKNK2(3), NRAS(3), PCK1(6), PCK2(1), PDE3A(8), PDE3B(2), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PHKA1(6), PHKA2(3), PHKB(8), PHKG2(2), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PKLR(3), PPARGC1A(6), PPP1CA(2), PPP1CC(1), PPP1R3A(6), PPP1R3C(1), PRKAA1(4), PRKAB2(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAG2(3), PRKAG3(2), PRKAR1B(1), PRKAR2B(3), PRKCZ(4), PRKX(3), PYGB(2), PYGL(2), PYGM(8), RAF1(2), RAPGEF1(8), RHEB(1), RPS6(2), RPS6KB1(2), RPS6KB2(4), SHC1(3), SHC4(4), SLC2A4(2), SOCS2(1), SOCS3(1), SORBS1(1), SOS1(8), SOS2(4), SREBF1(3), TRIP10(3), TSC1(8), TSC2(12)	92854979	340	175	329	78	27	89	41	102	78	3	0.00906	1.000	1.000
482	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(4), CADM3(2), CD22(5), CD226(1), CD276(1), CD4(1), CD40(3), CD58(1), CD6(3), CD80(4), CD86(2), CD8A(1), CD8B(1), CDH1(7), CDH15(6), CDH2(1), CDH3(1), CDH4(3), CDH5(2), CLDN1(1), CLDN16(3), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(3), CLDN4(1), CLDN5(1), CLDN8(2), CLDN9(2), CNTN1(7), CNTN2(6), CNTNAP2(8), CTLA4(1), ESAM(2), F11R(1), GLG1(6), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOB(1), HLA-DPB1(5), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(3), HLA-G(3), ICAM1(1), ICAM3(1), ITGA4(5), ITGA6(3), ITGA8(1), ITGA9(5), ITGAL(5), ITGAM(6), ITGAV(3), ITGB2(8), ITGB7(1), ITGB8(5), JAM2(3), JAM3(5), L1CAM(7), MADCAM1(1), MAG(2), MPZ(1), NCAM1(5), NCAM2(4), NEGR1(2), NEO1(4), NFASC(10), NLGN1(13), NLGN2(2), NLGN3(2), NRCAM(8), NRXN1(8), NRXN2(4), NRXN3(6), OCLN(3), PDCD1(1), PDCD1LG2(1), PTPRC(8), PTPRM(11), PVR(3), PVRL1(2), PVRL2(2), PVRL3(2), SDC2(1), SDC3(1), SDC4(2), SELE(1), SELP(1), SELPLG(1), SIGLEC1(6), SPN(3), VCAM1(3), VCAN(12)	84117436	321	174	314	90	21	75	35	118	72	0	0.426	1.000	1.000
483	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	AKT1(2), AKT2(3), AKT3(2), CBL(4), CBLB(3), CBLC(1), CCND1(1), CCND2(3), CISH(5), CLCF1(2), CNTFR(2), CREBBP(6), CRLF2(1), CSF2RB(2), CSF3R(1), EP300(11), EPOR(1), GH1(1), GH2(3), GHR(3), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IFNG(3), IFNGR1(3), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(3), IL10RB(2), IL11RA(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL13RA1(2), IL13RA2(2), IL20RA(3), IL21R(8), IL22(1), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL2RA(1), IL2RB(2), IL2RG(1), IL4(1), IL4R(1), IL5(1), IL5RA(1), IL6(2), IL6R(3), IL6ST(12), IL7(1), IL7R(1), IL9R(2), IRF9(2), JAK1(13), JAK2(4), JAK3(7), LEP(2), LEPR(4), LIF(1), LIFR(5), MPL(1), MYC(2), OSMR(1), PIAS2(2), PIAS3(1), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PIM1(1), PRL(3), PRLR(1), PTPN11(4), PTPN6(2), SOCS2(1), SOCS3(1), SOCS5(2), SOCS7(1), SOS1(8), SOS2(4), SPRED1(1), SPRY1(3), SPRY2(3), SPRY3(1), SPRY4(1), STAM(2), STAT1(5), STAT3(4), STAT4(4), STAT5A(2), STAT5B(1), STAT6(5), TPO(13), TSLP(1), TYK2(1)	82591101	320	170	306	83	19	73	35	123	69	1	0.221	1.000	1.000
484	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(5), ADCY2(14), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), DRD1(1), DRD2(4), EGF(6), EGFR(6), GJA1(1), GJD2(2), GNAI1(4), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(10), GRM1(4), GRM5(5), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), HTR2C(3), ITPR1(15), ITPR2(11), ITPR3(11), KRAS(6), MAP2K2(2), MAP2K5(1), MAP3K2(5), MAPK1(3), MAPK7(3), NPR1(2), NPR2(3), NRAS(3), PDGFA(2), PDGFB(1), PDGFC(3), PDGFD(3), PDGFRA(5), PDGFRB(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKG1(6), PRKG2(4), PRKX(3), RAF1(2), SOS1(8), SOS2(4), SRC(3), TJP1(6), TUBA1A(1), TUBA3C(2), TUBA3D(2), TUBA3E(4), TUBA4A(3), TUBA8(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(2)	76050418	295	162	288	71	25	73	29	106	60	2	0.0632	1.000	1.000
485	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(5), ADCY2(14), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ATF4(4), CACNA1C(9), CACNA1D(6), CACNA1F(3), CACNA1S(6), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CDC42(3), CGA(1), EGFR(6), GNAQ(1), GNAS(10), GNRH1(2), GNRH2(1), ITPR1(15), ITPR2(11), ITPR3(11), JUN(2), KRAS(6), LHB(2), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK7(3), MAPK8(1), MAPK9(3), MMP14(3), MMP2(1), NRAS(3), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLD1(4), PLD2(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKX(3), PTK2B(5), RAF1(2), SOS1(8), SOS2(4), SRC(3)	74562663	304	162	295	57	28	68	33	97	75	3	0.000381	1.000	1.000
486	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(5), CASP3(3), CD244(2), CD247(1), FAS(3), FYN(1), GZMB(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-E(3), HLA-G(3), ICAM1(1), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IFNG(3), IFNGR1(3), IFNGR2(1), ITGAL(5), ITGB2(8), KIR2DL3(3), KLRC1(1), KLRC3(2), KLRK1(5), KRAS(6), LAT(1), LCK(4), LCP2(5), MAP2K2(2), MAPK1(3), MICA(2), NCR1(2), NCR2(1), NCR3(1), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NRAS(3), PAK1(3), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PLCG2(7), PPP3CA(3), PPP3CB(3), PRF1(4), PRKCA(1), PRKCG(4), PTK2B(5), PTPN11(4), PTPN6(2), RAC3(1), RAF1(2), SH2D1A(1), SH3BP2(2), SHC1(3), SHC4(4), SOS1(8), SOS2(4), SYK(1), TNF(1), TNFRSF10B(2), TNFRSF10D(2), TNFSF10(1), VAV1(3), VAV3(8), ZAP70(3)	64523862	266	155	252	52	18	66	28	99	54	1	0.00422	1.000	1.000
487	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(5), CACNA1A(9), CRH(1), CRHR1(5), GNA12(1), GNA13(1), GNAI1(4), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(10), GNAZ(2), GRIA1(10), GRIA2(9), GRIA3(6), GRID2(4), GRM1(4), GRM5(5), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), IGF1R(11), ITPR1(15), ITPR2(11), ITPR3(11), KRAS(6), LYN(1), MAP2K2(2), MAPK1(3), NOS1(14), NOS3(9), NPR1(2), NPR2(3), NRAS(3), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), PRKCA(1), PRKCG(4), PRKG1(6), PRKG2(4), RAF1(2), RYR1(31)	64238118	301	155	289	58	33	58	33	120	57	0	0.000788	1.000	1.000
488	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(2), BCAR1(3), CAPN1(2), CAPN10(1), CAPN11(8), CAPN2(1), CAPN3(3), CAPN6(4), CAPN7(2), CAPN9(3), CAPNS1(1), CAV1(1), CAV2(1), CDC42(3), CSK(1), DOCK1(7), FYN(1), GIT2(2), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAD(10), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(3), ITGAX(2), ITGB2(8), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), MAP2K2(2), MAP2K3(2), MAP2K6(2), MAPK10(3), MAPK12(1), MAPK4(5), MAPK6(3), MAPK7(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PDPK1(1), PIK3R2(4), PTK2(9), PXN(2), RAC3(1), RAPGEF1(8), RHO(3), ROCK1(6), ROCK2(3), SDCCAG8(6), SHC1(3), SORBS1(1), SOS1(8), SRC(3), TLN1(10), TNS1(10), VASP(2), VAV3(8), VCL(3), ZYX(2)	78104132	293	153	291	66	24	75	22	97	74	1	0.0516	1.000	1.000
489	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA1(1), ADORA2A(2), ADORA2B(1), ADORA3(2), ADRA1B(1), ADRA1D(4), ADRA2C(1), ADRB2(3), ADRB3(1), AGTR1(2), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB2(3), C3AR1(1), CCKAR(1), CCKBR(3), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR6(5), CCR7(2), CCR8(1), CCR9(1), CHML(2), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), CMKLR1(2), CNR1(3), CNR2(1), CXCR3(3), CXCR4(2), DRD1(1), DRD2(4), DRD3(2), DRD5(1), EDNRA(1), EDNRB(2), F2R(1), F2RL3(1), FPR1(1), FSHR(4), GALR2(1), GHSR(2), GNB2L1(1), GPR17(1), GPR173(2), GPR174(4), GPR3(3), GPR35(2), GPR37(3), GPR37L1(1), GPR4(2), GPR50(2), GPR63(7), GPR83(4), GPR85(2), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(2), HRH1(2), HRH3(2), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(3), HTR1F(1), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5), LHCGR(6), LTB4R(1), MC3R(2), MC4R(2), MC5R(1), MTNR1A(2), MTNR1B(3), NMBR(1), NMUR1(3), NMUR2(6), NPY1R(3), NPY2R(4), NPY5R(5), NTSR2(3), OPN3(1), OPRK1(3), OPRL1(2), OPRM1(4), OR10A5(2), OR11A1(3), OR12D3(3), OR1C1(2), OR1Q1(1), OR2H1(1), OR5V1(3), OR7A5(3), OR8B8(3), OXTR(1), P2RY1(4), P2RY10(3), P2RY11(2), P2RY12(3), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), PTGER1(1), PTGER2(3), PTGER4(1), PTGFR(2), PTGIR(2), RGR(1), RHO(3), RRH(2), SSTR2(1), SSTR3(5), SSTR4(3), SUCNR1(2), TRHR(3)	67932500	283	152	274	86	34	53	26	137	33	0	0.254	1.000	1.000
490	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(1), ACTN2(6), ACTN4(2), DES(3), DMD(19), MYBPC1(1), MYBPC2(3), MYBPC3(2), MYH3(6), MYH6(9), MYH7(13), MYH8(5), MYOM1(13), NEB(17), TCAP(1), TMOD1(1), TNNC2(2), TNNI2(1), TNNT3(1), TPM2(3), TPM3(1), TPM4(1), TTN(133), VIM(4)	79225948	249	152	247	76	14	52	35	102	43	3	0.621	1.000	1.000
491	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(2), ACTN1(4), ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ANGPTL2(1), ARHGEF6(3), ARHGEF7(4), BCAR1(3), CAV1(1), CDC42(3), CDKN2A(11), CSE1L(1), DOCK1(7), EPHB2(4), FYN(1), GRB7(1), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGB3BP(1), MAP2K4(4), MAP2K7(2), MAP3K11(1), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MYLK(3), MYLK2(2), P4HB(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PIK3CA(13), PIK3CB(5), PKLR(3), PLCG1(7), PLCG2(7), PTEN(11), PTK2(9), RAF1(2), RALA(2), RHO(3), ROCK1(6), ROCK2(3), SHC1(3), SOS1(8), SOS2(4), SRC(3), TERF2IP(1), TLN1(10), TLN2(9), VASP(2), ZYX(2)	70275417	268	150	261	56	20	56	26	89	76	1	0.0251	1.000	1.000
492	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(5), ADCY8(9), ARAF(5), ATF4(4), CACNA1C(9), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CREBBP(6), EP300(11), GNAQ(1), GRIA1(10), GRIA2(9), GRIN1(5), GRIN2A(6), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRM1(4), GRM5(5), ITPR1(15), ITPR2(11), ITPR3(11), KRAS(6), MAP2K2(2), MAPK1(3), NRAS(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PPP1CA(2), PPP1CC(1), PPP1R12A(2), PPP3CA(3), PPP3CB(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), RAF1(2), RAP1A(2), RAPGEF3(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), RPS6KA6(8)	58270496	247	148	240	60	19	58	27	87	55	1	0.0587	1.000	1.000
493	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(2), ABL2(4), AKT1(2), AKT2(3), AKT3(2), ARAF(5), BTC(1), CAMK2A(6), CAMK2B(2), CAMK2G(3), CBL(4), CBLB(3), CBLC(1), CDKN1A(6), CDKN1B(5), EGF(6), EGFR(6), ERBB2(4), ERBB3(8), ERBB4(11), GAB1(3), GSK3B(3), JUN(2), KRAS(6), MAP2K2(2), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK9(3), MYC(2), NCK1(1), NCK2(2), NRAS(3), NRG1(2), NRG2(1), NRG3(3), NRG4(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PLCG2(7), PRKCA(1), PRKCG(4), PTK2(9), RAF1(2), RPS6KB1(2), RPS6KB2(4), SHC1(3), SHC4(4), SOS1(8), SOS2(4), SRC(3), STAT5A(2), STAT5B(1), TGFA(1)	59127208	253	144	239	49	14	60	28	90	60	1	0.00541	1.000	1.000
494	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(2), AKT2(3), AKT3(2), BCL10(1), CARD11(11), CBL(4), CBLB(3), CBLC(1), CD247(1), CD3G(1), CD4(1), CD8A(1), CD8B(1), CDC42(3), CHUK(8), CTLA4(1), FOS(1), FYN(1), GRAP2(3), IFNG(3), IKBKB(4), IL10(1), IL4(1), IL5(1), ITK(1), JUN(2), KRAS(6), LAT(1), LCK(4), LCP2(5), MALT1(3), MAP3K8(1), NCK1(1), NCK2(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKB2(2), NFKBIA(2), NRAS(3), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PDCD1(1), PDK1(1), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCQ(3), PTPN6(2), PTPRC(8), RASGRP1(5), SOS1(8), SOS2(4), TNF(1), VAV1(3), VAV3(8), ZAP70(3)	58050613	239	144	229	45	17	63	28	82	48	1	0.00307	1.000	1.000
495	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(8), ABCA10(6), ABCA12(20), ABCA13(36), ABCA2(8), ABCA3(6), ABCA4(15), ABCA5(4), ABCA6(4), ABCA7(6), ABCA8(2), ABCA9(7), ABCB1(8), ABCB10(2), ABCB11(2), ABCB4(5), ABCB5(12), ABCB6(3), ABCB7(3), ABCB8(2), ABCB9(1), ABCC1(3), ABCC10(6), ABCC11(3), ABCC12(3), ABCC2(4), ABCC3(5), ABCC4(4), ABCC5(5), ABCC6(7), ABCC8(7), ABCC9(6), ABCD1(2), ABCD2(3), ABCD3(1), ABCG1(1), ABCG2(2), ABCG4(6), ABCG5(6), ABCG8(1), CFTR(3), TAP1(2)	68015304	240	143	235	56	16	58	23	92	50	1	0.0363	1.000	1.000
496	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALML6(2), CDIPT(1), CDS1(2), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKI(5), DGKQ(1), DGKZ(2), FN3K(1), IMPA1(2), IMPA2(2), INPP4A(1), INPP4B(6), INPP5A(3), INPP5B(1), INPP5E(2), INPPL1(1), ITPK1(2), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), OCRL(4), PI4KA(4), PI4KB(2), PIK3C2A(4), PIK3C2B(8), PIK3C2G(7), PIK3C3(2), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PIP4K2A(1), PIP4K2B(3), PIP4K2C(1), PIP5K1B(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(7), PLCG2(7), PLCZ1(3), PRKCA(1), PRKCG(4), PTEN(11), PTPMT1(1), SYNJ1(7), SYNJ2(3)	72463979	248	142	238	61	17	59	30	70	72	0	0.114	1.000	1.000
497	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(5), ADCY2(14), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), AKAP1(3), AKAP10(1), AKAP11(9), AKAP12(3), AKAP2(4), AKAP3(4), AKAP4(2), AKAP5(1), AKAP6(10), AKAP7(1), AKAP8(3), AKAP9(8), ARHGEF1(1), CHMP1B(3), GNA12(1), GNA13(1), GNA15(1), GNAI2(1), GNAI3(1), GNAL(2), GNAQ(1), GNAZ(2), GNB1(2), GNB2(3), GNB5(4), GNG12(1), GNG4(1), ITPR1(15), KCNJ3(3), KRAS(6), NRAS(3), PDE1A(2), PDE1B(2), PDE1C(9), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(4), PDE7A(2), PDE7B(1), PDE8A(5), PDE8B(1), PLCB3(4), PPP3CA(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), SLC9A1(6), USP5(4)	66096121	233	141	227	59	18	59	23	81	51	1	0.165	1.000	1.000
498	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(5), ADCY2(14), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ADK(1), ADSL(2), ADSS(2), AK1(1), AK2(1), AK5(1), AK7(5), ALLC(2), AMPD1(5), AMPD2(2), AMPD3(3), ATIC(2), ENPP1(1), ENPP3(4), ENTPD1(3), ENTPD2(1), ENTPD5(1), ENTPD6(3), GART(4), GDA(2), GMPR2(1), GMPS(4), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), GUK1(1), IMPDH1(1), NME1(2), NME2(1), NME6(2), NME7(1), NPR1(2), NPR2(3), NT5C1B(3), NT5C2(1), NT5E(1), NT5M(2), NUDT5(1), PAICS(2), PAPSS1(2), PAPSS2(1), PDE10A(6), PDE11A(7), PDE1A(2), PDE1C(9), PDE2A(1), PDE3B(2), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(4), PDE5A(3), PDE7A(2), PDE7B(1), PDE8A(5), PDE8B(1), PDE9A(2), PFAS(3), PKLR(3), PNPT1(3), POLA1(4), POLD1(4), POLD4(1), POLE(4), POLE2(4), POLE3(1), POLR1A(7), POLR1B(2), POLR1C(1), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(3), POLR3B(2), POLR3H(1), PPAT(4), PRIM1(3), PRPS1(1), PRPS1L1(1), PRUNE(2), RFC5(2), RRM1(5), XDH(8), ZNRD1(1)	93681107	289	141	285	82	22	76	18	94	77	2	0.520	1.000	1.000
499	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(2), ACVR1B(2), ACVR1C(1), ACVR2A(13), ACVR2B(3), ACVRL1(1), AMH(1), AMHR2(2), BMP2(2), BMP4(1), BMP5(4), BMP6(2), BMP7(3), BMPR1A(1), BMPR1B(2), BMPR2(5), CDKN2B(1), CHRD(2), COMP(5), CREBBP(6), CUL1(2), DCN(2), E2F4(2), EP300(11), FST(2), GDF5(2), ID1(2), IFNG(3), INHBA(3), INHBC(1), INHBE(2), LEFTY2(1), LTBP1(9), MAPK1(3), MYC(2), NODAL(1), PITX2(1), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), RBL1(4), RBL2(11), ROCK1(6), ROCK2(3), RPS6KB1(2), RPS6KB2(4), SMAD2(1), SMAD3(3), SMAD4(5), SMAD6(1), SMAD9(2), SMURF1(4), SMURF2(1), SP1(2), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TNF(1), ZFYVE16(6), ZFYVE9(6)	56401215	213	138	210	52	18	46	25	67	53	4	0.113	1.000	1.000
500	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(5), ADCY2(14), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADK(1), ADSL(2), ADSS(2), AK1(1), AK2(1), AK5(1), ALLC(2), AMPD1(5), AMPD2(2), AMPD3(3), ATIC(2), ATP5A1(4), ATP5B(4), ATP5C1(1), ATP5F1(1), ATP5G2(1), ENPP1(1), ENPP3(4), ENTPD1(3), ENTPD2(1), GART(4), GDA(2), GMPS(4), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), GUK1(1), IMPDH1(1), NME1(2), NME2(1), NPR1(2), NPR2(3), NT5E(1), NT5M(2), PAICS(2), PAPSS1(2), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(4), PDE5A(3), PDE6B(8), PDE7B(1), PDE8A(5), PDE9A(2), PFAS(3), PKLR(3), POLB(2), POLD1(4), POLE(4), POLG(5), POLL(1), POLQ(17), POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1), PPAT(4), PRPS1(1), PRPS1L1(1), PRUNE(2), RRM1(5)	73572655	241	137	238	69	18	71	20	82	50	0	0.412	1.000	1.000
501	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(2), ACVR1B(2), ACVRL1(1), AKT1(2), BMPR1A(1), BMPR2(5), BUB1(2), CDIPT(1), CDKL1(2), CDKL2(3), CDS1(2), CLK1(2), CLK2(5), CLK4(5), COL4A3BP(1), CSNK2A1(2), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKQ(1), DGKZ(2), IMPA1(2), INPP4A(1), INPP4B(6), INPP5A(3), INPPL1(1), ITPKA(1), ITPKB(4), MAP3K10(1), MOS(2), NEK1(1), NEK3(1), OCRL(4), PAK4(2), PIK3C2A(4), PIK3C2B(8), PIK3C2G(7), PIK3CA(13), PIK3CB(5), PIK3CG(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCG1(7), PLCG2(7), PLK3(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), PRKG1(6), RAF1(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), RPS6KA4(2), RPS6KB1(2), STK11(1), TGFBR1(1)	65528788	237	134	225	59	13	56	28	70	70	0	0.197	1.000	1.000
502	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(2), AKT2(3), AKT3(2), CASP8(1), CCL3(1), CD40(3), CD80(4), CD86(2), CHUK(8), FADD(1), FOS(1), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IKBKB(4), IKBKE(1), IL12A(6), IL12B(2), IL1B(1), IL6(2), IRAK1(5), IRAK4(4), IRF3(1), IRF5(1), IRF7(1), JUN(2), LBP(3), LY96(1), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAP3K7(3), MAP3K8(1), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK9(3), MYD88(1), NFKB1(3), NFKB2(2), NFKBIA(2), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), RELA(4), RIPK1(4), STAT1(5), TBK1(1), TICAM1(1), TIRAP(2), TLR1(2), TLR2(1), TLR3(5), TLR4(5), TLR5(1), TLR6(4), TLR7(4), TLR8(7), TLR9(3), TNF(1), TRAF3(1), TRAF6(2)	50990589	214	131	207	49	9	57	32	64	52	0	0.0821	1.000	1.000
503	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	83	AGL(3), AMY2A(2), AMY2B(1), ASCC3(14), ATP13A2(3), DDX18(3), DDX23(2), DDX4(4), DDX41(1), DDX47(2), DDX50(7), DDX51(1), DDX52(1), DDX54(1), DDX55(1), DDX56(1), DHX58(1), ENPP1(1), ENPP3(4), ENTPD7(1), EP400(6), ERCC2(6), ERCC3(3), G6PC(3), GAA(2), GBE1(2), GPI(1), GUSB(8), GYS1(3), GYS2(5), HK1(3), HK2(3), HK3(5), LYZL1(1), MGAM(9), MOV10L1(1), NUDT5(1), PGM1(1), PGM3(2), PYGB(2), PYGL(2), PYGM(8), RAD54B(6), RUVBL2(1), SETX(8), SI(9), SKIV2L2(4), SMARCA2(9), SMARCA5(3), UGDH(2), UGP2(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5)	74961060	203	124	198	76	12	56	16	57	59	3	0.983	1.000	1.000
504	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	ATF2(1), CEBPA(5), CHUK(8), CREB1(1), DAXX(1), FOS(1), IKBKB(4), JUN(2), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K5(1), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K13(4), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAP3K5(1), MAP3K6(1), MAP3K7(3), MAP3K8(1), MAP3K9(3), MAP4K1(1), MAP4K2(4), MAP4K3(1), MAP4K4(4), MAP4K5(7), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK4(5), MAPK6(3), MAPK7(3), MAPK8(1), MAPK9(3), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(3), MEF2A(6), MEF2C(1), MEF2D(3), MKNK1(2), MKNK2(3), MYC(2), NFKB1(3), NFKBIA(2), PAK1(3), PAK2(3), RAF1(2), RELA(4), RIPK1(4), RPS6KA1(1), RPS6KA2(5), RPS6KA3(15), RPS6KA4(2), RPS6KA5(5), RPS6KB1(2), RPS6KB2(4), SHC1(3), SP1(2), STAT1(5), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1)	56500034	209	123	204	43	14	52	23	71	48	1	0.0131	1.000	1.000
505	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	69	A2M(5), BDKRB2(3), C1QA(3), C1QC(1), C2(4), C3(10), C3AR1(1), C4A(2), C4B(1), C4BPA(3), C4BPB(1), C5(5), C6(1), C7(1), C8A(4), C8B(4), C9(2), CD46(3), CD55(3), CFB(5), CFH(7), CFI(2), CPB2(2), CR1(9), CR2(9), F10(3), F11(1), F12(1), F13A1(2), F13B(1), F2(2), F2R(1), F3(1), F5(7), F8(5), FGA(12), FGB(3), KLKB1(3), KNG1(3), MASP1(2), MASP2(3), MBL2(1), PLAT(2), PLG(3), PROC(2), SERPINA1(1), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPING1(3), TFPI(2), THBD(3), VWF(7)	59806826	170	122	169	48	7	39	28	51	45	0	0.348	1.000	1.000
506	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(10), ACSL1(1), ACSL3(2), ACSL5(1), ACSL6(3), ADIPOQ(3), ADIPOR1(2), ADIPOR2(1), AGRP(2), AKT1(2), AKT2(3), AKT3(2), CAMKK1(1), CAMKK2(3), CD36(3), CHUK(8), CPT1A(4), CPT1B(4), CPT2(1), G6PC(3), IKBKB(4), IRS1(3), IRS2(2), IRS4(7), JAK1(13), JAK2(4), JAK3(7), LEP(2), LEPR(4), MAPK10(3), MAPK8(1), MAPK9(3), NFKB1(3), NFKB2(2), NFKBIA(2), PCK1(6), PCK2(1), POMC(2), PPARA(3), PPARGC1A(6), PRKAA1(4), PRKAB2(1), PRKAG2(3), PRKAG3(2), PRKCQ(3), PTPN11(4), RELA(4), RXRA(2), RXRB(8), RXRG(2), SLC2A4(2), SOCS3(1), STAT3(4), STK11(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TYK2(1)	47903881	182	120	177	47	11	38	23	69	40	1	0.359	1.000	1.000
507	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	85	ANPEP(3), CD19(2), CD1A(2), CD1B(4), CD1D(2), CD1E(3), CD22(5), CD33(1), CD36(3), CD37(2), CD38(3), CD3G(1), CD4(1), CD44(4), CD5(1), CD55(3), CD7(1), CD8A(1), CD8B(1), CD9(1), CR1(9), CR2(9), CSF1(2), CSF1R(1), CSF3R(1), EPOR(1), FCER2(1), FLT3(4), FLT3LG(2), GP1BB(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), IL11RA(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(1), IL4(1), IL4R(1), IL5(1), IL5RA(1), IL6(2), IL6R(3), IL7(1), IL7R(1), IL9R(2), ITGA1(5), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGAM(6), ITGB3(5), KIT(12), KITLG(2), MME(6), TFRC(2), TNF(1), TPO(13)	47777826	175	119	173	57	8	42	21	64	39	1	0.758	1.000	1.000
508	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG1(1), ALG10B(3), ALG11(1), ALG13(1), ALG14(1), ALG2(1), ALG6(1), ALG8(1), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT6(3), B3GNT7(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), B4GALT7(1), C1GALT1(1), C1GALT1C1(1), CHPF(5), CHST11(2), CHST12(2), CHST13(3), CHST14(1), CHST2(3), CHST3(5), CHST6(2), CHST7(2), CHSY1(2), DDOST(1), EXT1(1), EXT2(4), EXTL1(2), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(1), GALNT11(1), GALNT12(5), GALNT13(4), GALNT14(3), GALNT3(2), GALNT4(4), GALNT5(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL5(4), GANAB(3), GCNT3(2), GCNT4(1), HS2ST1(3), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST5(4), HS6ST2(1), HS6ST3(1), MAN1A1(3), MAN1A2(3), MAN1B1(1), MAN1C1(1), MAN2A1(8), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), MGAT5B(3), NDST1(2), NDST2(2), NDST3(4), NDST4(6), OGT(3), RPN1(1), RPN2(2), ST3GAL1(1), ST3GAL2(1), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(3), WBSCR17(7), XYLT1(3), XYLT2(1)	63290497	192	116	191	58	23	45	20	68	35	1	0.491	1.000	1.000
509	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	BCL2(1), CABIN1(5), CAMK2B(2), CD3G(1), CD69(2), CDKN1A(6), CNR1(3), CREBBP(6), CSNK2A1(2), CTLA4(1), EGR2(1), EGR3(2), EP300(11), FCER1A(1), FOS(1), GATA3(1), GSK3A(1), GSK3B(3), IFNB1(2), IFNG(3), IL10(1), IL1B(1), IL2RA(1), IL4(1), IL6(2), ITK(1), JUNB(1), KPNA5(1), MAP2K7(2), MAPK14(3), MAPK8(1), MAPK9(3), MEF2A(6), MEF2D(3), MYF5(2), NCK2(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB2(2), NPPB(1), NUP214(9), P2RX7(1), PAK1(3), PIN1(2), PPP3CB(3), PTPRC(8), RELA(4), SLA(1), SP1(2), SP3(3), TGFB1(1), TNF(1), TRPV6(2), VAV1(3), VAV3(8), XPO5(4)	52151167	168	114	165	49	8	39	16	67	38	0	0.503	1.000	1.000
510	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(2), CDC40(2), CLK2(5), CLK3(2), CLK4(5), COL2A1(9), CPSF1(8), CPSF2(4), CPSF3(2), CPSF4(2), CSTF1(1), CSTF2(2), CSTF2T(2), CSTF3(1), DDX1(2), DDX20(3), DHX15(3), DHX16(3), DHX38(1), DHX8(6), DHX9(14), DICER1(7), DNAJC8(1), FUS(2), GIPC1(3), NCBP1(4), NCBP2(1), NONO(2), NXF1(3), PABPN1(1), PAPOLA(3), POLR2A(7), PPM1G(3), PRPF4(1), PRPF4B(2), PRPF8(8), PSKH1(4), PTBP1(4), PTBP2(2), RBM17(2), RBM5(4), RNGTT(2), RNMT(1), RNPS1(2), SF3A1(3), SF3A2(1), SF3A3(3), SF3B1(12), SF3B2(2), SF3B4(2), SNRPA(1), SNRPA1(2), SNRPB2(1), SNRPD3(1), SNRPN(4), SNURF(2), SPOP(4), SRPK1(1), SRPK2(1), SRRM1(4), SUPT5H(4), TXNL4A(1), U2AF2(4), XRN2(4)	60138465	205	114	200	45	13	42	13	74	62	1	0.113	1.000	1.000
511	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(3), ADAM17(5), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(2), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), CASP3(3), CDC42(3), CHUK(8), CSK(1), CXCL1(1), EGFR(6), F11R(1), GIT1(2), IGSF5(4), IKBKB(4), JAM2(3), JAM3(5), JUN(2), LYN(1), MAP2K4(4), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK9(3), MET(2), NFKB1(3), NFKB2(2), NFKBIA(2), NOD1(1), PAK1(3), PLCG1(7), PLCG2(7), PTPN11(4), PTPRZ1(11), RELA(4), SRC(3), TJP1(6)	40517055	154	108	151	31	6	34	17	56	41	0	0.130	1.000	1.000
512	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(11), ASH2L(2), CTCFL(2), DOT1L(7), EED(2), EHMT1(4), EHMT2(5), EZH1(5), EZH2(2), FBXO11(4), HCFC1(4), HSF4(2), JMJD6(3), KDM6A(2), MEN1(3), NSD1(8), OGT(3), PAXIP1(2), PPP1CA(2), PPP1CC(1), PRDM2(4), PRDM6(2), PRDM7(1), PRDM9(2), PRMT1(2), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), RBBP5(2), SATB1(6), SETD1A(6), SETD1B(4), SETD2(17), SETD8(3), SETDB1(3), SETMAR(4), SMYD3(2), STK38(1), SUV39H1(1), SUV39H2(3), SUV420H1(6), SUZ12(3), WHSC1(5), WHSC1L1(6)	72117460	166	103	164	52	10	37	19	48	50	2	0.709	1.000	1.000
513	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(2), IMPA2(2), INPP4A(1), INPP4B(6), INPP5A(3), INPP5B(1), INPP5E(2), INPPL1(1), IPMK(1), ISYNA1(1), ITPK1(2), ITPKA(1), ITPKB(4), MINPP1(1), MIOX(1), OCRL(4), PI4KA(4), PI4KB(2), PIK3C3(2), PIK3CA(13), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIP4K2A(1), PIP4K2B(3), PIP4K2C(1), PIP5K1B(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(7), PLCG2(7), PLCZ1(3), PTEN(11), PTPMT1(1), SYNJ1(7), SYNJ2(3)	42743651	148	103	139	40	10	31	22	43	42	0	0.299	1.000	1.000
514	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ANGPTL2(1), ARHGAP1(1), ARHGAP4(2), ARHGEF11(6), CDC42(3), CFL1(1), CFL2(2), GDI2(3), INPPL1(1), ITPR1(15), ITPR2(11), ITPR3(11), LIMK1(4), MYLK(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PDK1(1), PIK3CA(13), PIK3CD(5), PIK3CG(3), PIK3R1(4), PITX2(1), PPP1R13B(4), PTEN(11), RACGAP1(5), RHO(3), ROCK1(6), ROCK2(3), SAG(2), WASF1(1), WASL(2)	40040278	161	103	155	36	16	34	15	56	40	0	0.112	1.000	1.000
515	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(9), BAG4(1), BCL2(1), BIRC2(4), BIRC3(1), CASP3(3), CASP6(2), CASP8(1), CASP9(1), CFLAR(2), CHUK(8), CRADD(1), DAXX(1), DFFB(1), FADD(1), GSN(2), LMNA(2), LMNB2(2), MAP2K7(2), MAP3K1(3), MAP3K5(1), MAPK8(1), MDM2(1), NFKB1(3), NFKBIA(2), NUMA1(4), PAK2(3), PRKDC(6), PSEN1(2), PSEN2(2), PTK2(9), RASA1(10), RB1(24), RELA(4), RIPK1(4), SPTAN1(7), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1)	39835042	136	100	135	31	2	31	7	37	58	1	0.380	1.000	1.000
516	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	EGFR(6), ERBB2(4), ERBB4(11), ETS1(2), ETS2(1), ETV6(1), ETV7(1), FMN2(18), KRAS(6), MAPK1(3), NOTCH1(7), NOTCH2(10), NOTCH3(12), NOTCH4(10), PIWIL1(4), PIWIL2(2), PIWIL3(5), PIWIL4(6), RAF1(2), SOS1(8), SOS2(4), SPIRE1(6), SPIRE2(1)	30308750	130	99	127	31	9	29	23	48	20	1	0.100	1.000	1.000
517	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(2), BMP4(1), BMP5(4), BMP6(2), BMP7(3), BTRC(5), CSNK1A1(2), CSNK1A1L(3), CSNK1E(3), CSNK1G1(2), FBXW11(1), GAS1(1), GLI1(5), GLI2(12), GLI3(11), GSK3B(3), HHIP(3), LRP2(18), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(3), PTCH1(1), PTCH2(4), RAB23(2), SHH(1), SMO(1), STK36(2), SUFU(3), WNT1(2), WNT11(1), WNT2(3), WNT3A(2), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2)	34801319	125	98	124	35	18	24	11	51	19	2	0.341	1.000	1.000
518	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(4), ADCY6(4), ADCY8(9), CACNA1A(9), CACNA1B(13), GNAS(10), GNAT3(4), GNB1(2), GRM4(4), ITPR3(11), KCNB1(2), PDE1A(2), PLCB2(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(3), SCNN1A(1), SCNN1B(1), SCNN1G(5), TAS1R1(1), TAS1R2(3), TAS1R3(4), TAS2R1(1), TAS2R10(1), TAS2R13(2), TAS2R16(1), TAS2R3(1), TAS2R38(2), TAS2R39(2), TAS2R41(3), TAS2R42(2), TAS2R46(2), TAS2R50(1), TAS2R60(1), TAS2R7(2), TAS2R8(2), TAS2R9(1), TRPM5(3)	33586515	128	98	124	38	17	37	10	44	19	1	0.460	1.000	1.000
519	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(5), CREBBP(6), CTBP1(1), DLL1(2), DTX1(1), DTX2(2), DTX3(5), DTX3L(2), DTX4(2), DVL1(3), DVL2(6), DVL3(1), EP300(11), HDAC2(3), HES1(2), JAG1(2), JAG2(4), LFNG(7), MAML1(2), MAML2(2), MAML3(5), NCOR2(14), NCSTN(4), NOTCH1(7), NOTCH2(10), NOTCH3(12), NOTCH4(10), NUMB(3), NUMBL(1), PSEN1(2), PSEN2(2), PSENEN(1), RBPJ(1), RBPJL(1), SNW1(3)	41505231	145	97	141	42	21	30	13	50	31	0	0.446	1.000	1.000
520	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), ALG6(1), CCKBR(3), CCR2(1), CCR3(3), CCR5(2), CELSR1(12), CELSR2(10), CELSR3(11), CHRM2(5), CHRM3(7), CXCR3(3), EDNRA(1), EMR2(1), EMR3(4), F2R(1), FSHR(4), GHRHR(1), GPR116(4), GPR132(3), GPR133(1), GPR135(1), GPR143(1), GPR17(1), GPR55(1), GPR61(2), GPR84(5), GRM1(4), GRPR(1), HRH4(1), LGR6(5), LPHN2(3), LPHN3(12), P2RY11(2), P2RY13(1), PTGFR(2), SMO(1), SSTR2(1), TAAR5(1), TSHR(2), VN1R1(1)	37710561	128	91	127	35	10	34	10	53	21	0	0.341	1.000	1.000
521	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), ATP8A1(8), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB2(3), C3AR1(1), CCKAR(1), CCKBR(3), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR6(5), CCR7(2), CCR8(1), CXCR3(3), CXCR4(2), EDNRA(1), EDNRB(2), FPR1(1), FSHR(4), GALR2(1), GHSR(2), GNB2L1(1), GRPR(1), LHCGR(6), MC2R(3), MC3R(2), MC4R(2), MC5R(1), NMBR(1), NPY1R(3), NPY2R(4), NPY5R(5), NTSR2(3), OPRK1(3), OPRL1(2), OPRM1(4), OXTR(1), SSTR2(1), SSTR3(5), SSTR4(3), TACR1(2), TACR2(2), TACR3(4), TRHR(3), TSHR(2)	29021776	120	87	117	35	14	21	11	56	18	0	0.355	1.000	1.000
522	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(5), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPAT6(2), CDIPT(1), CDS1(2), CHAT(4), CHKA(1), CHPT1(1), CRLS1(1), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKI(5), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(3), ETNK1(1), GNPAT(3), GPAM(5), GPD1L(1), LCAT(3), LYPLA1(1), NAT6(1), PCYT1A(3), PCYT1B(1), PHOSPHO1(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLD1(4), PLD2(3), PNPLA3(1), PPAP2A(3), PPAP2B(1), PPAP2C(2), PTDSS1(2), PTDSS2(2), SH3GLB1(2)	38122195	119	83	117	31	4	29	18	32	36	0	0.234	1.000	1.000
523	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(4), CSK(1), CTLA4(1), DAG1(1), EPHB2(4), FBXW7(3), GRAP2(3), ITK(1), ITPKA(1), ITPKB(4), LAT(1), LCK(4), LCP2(5), MAPK1(3), NCK1(1), NFAT5(6), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PLCG1(7), PTPRC(8), RAF1(2), RASGRP1(5), RASGRP3(1), RASGRP4(3), SOS1(8), SOS2(4), VAV1(3), ZAP70(3)	32702919	118	83	115	28	7	31	12	50	17	1	0.227	1.000	1.000
524	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), AANAT(2), ACAT1(2), ACAT2(5), ACMSD(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC2(2), AOC3(1), AOX1(11), CAT(1), CYP1A1(3), CYP1B1(2), DDC(2), ECHS1(2), EHHADH(10), GCDH(1), HAAO(1), HADH(1), HADHA(3), HEMK1(3), HSD17B4(1), KMO(1), KYNU(3), LCMT2(3), MAOA(1), MAOB(8), METTL2B(5), METTL6(3), NFX1(4), OGDH(1), OGDHL(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), TPH1(2), TPH2(2), WARS(2), WARS2(1), WBSCR22(2)	34042511	115	82	115	30	5	29	16	38	26	1	0.224	1.000	1.000
525	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1C1(2), AKR1C2(1), AKR1C4(1), ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), CYP1A1(3), CYP1B1(2), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2E1(4), CYP2F1(1), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A5(4), DHDH(3), EPHX1(4), GSTA2(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM3(1), GSTM5(1), GSTP1(2), GSTZ1(2), MGST2(1), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5)	32183919	96	77	94	24	3	27	3	30	33	0	0.600	1.000	1.000
526	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), AK3(1), CAD(4), CDA(3), CTPS2(1), DCTD(1), DHODH(1), DPYD(6), DPYS(1), DUT(1), ENTPD1(3), ENTPD5(1), ENTPD6(3), NME1(2), NME2(1), NME6(2), NME7(1), NT5C1B(3), NT5C2(1), NT5E(1), NT5M(2), PNPT1(3), POLA1(4), POLD1(4), POLD4(1), POLE(4), POLE2(4), POLE3(1), POLR1A(7), POLR1B(2), POLR1C(1), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(3), POLR3B(2), POLR3H(1), PRIM1(3), RFC5(2), RRM1(5), TK1(2), TK2(1), TYMS(1), UCK2(1), UMPS(1), UPB1(1), UPP1(1), UPP2(1), UPRT(1), ZNRD1(1)	46347528	117	73	117	27	10	29	8	34	35	1	0.164	1.000	1.000
527	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(3), AMY2A(2), AMY2B(1), ENPP1(1), ENPP3(4), G6PC(3), GAA(2), GANAB(3), GBE1(2), GPI(1), GUSB(8), GYS1(3), GYS2(5), HK1(3), HK2(3), HK3(5), MGAM(9), PGM1(1), PGM3(2), PYGB(2), PYGL(2), PYGM(8), SI(9), UCHL1(1), UCHL3(2), UGDH(2), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5)	37795366	104	73	101	35	4	27	10	30	32	1	0.827	1.000	1.000
528	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(5), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPS(3), CDIPT(1), CDS1(2), CHAT(4), CHKA(1), CLC(1), CPT1B(4), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKQ(1), DGKZ(2), ETNK1(1), GNPAT(3), LCAT(3), LYPLA1(1), PAFAH1B1(1), PCYT1A(3), PCYT1B(1), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCB2(3), PLCG1(7), PLCG2(7), PPAP2A(3), PPAP2B(1), PPAP2C(2)	29209202	102	72	99	28	5	25	11	30	31	0	0.387	1.000	1.000
529	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(4), CDA(3), CTPS2(1), DCTD(1), DHODH(1), DPYD(6), DPYS(1), DUT(1), ENTPD1(3), NME1(2), NME2(1), NT5E(1), NT5M(2), POLB(2), POLD1(4), POLE(4), POLG(5), POLL(1), POLQ(17), POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1), RRM1(5), TK1(2), TK2(1), TYMS(1), UCK2(1), UMPS(1), UNG(3), UPB1(1), UPP1(1)	32876642	98	72	98	24	8	25	11	32	22	0	0.181	1.000	1.000
530	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), ASCC3(14), ATP13A2(3), DDX18(3), DDX23(2), DDX4(4), DDX41(1), DDX47(2), DDX50(7), DDX51(1), DDX52(1), DDX54(1), DDX55(1), DDX56(1), DHX58(1), ENTPD7(1), EP400(6), ERCC2(6), ERCC3(3), FPGS(1), MOV10L1(1), NUDT5(1), PTS(2), RAD54B(6), RUVBL2(1), SETX(8), SKIV2L2(4), SMARCA2(9), SMARCA5(3)	35900888	102	71	101	40	8	31	8	28	25	2	0.956	1.000	1.000
531	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AGK(1), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPAT6(2), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CEL(3), DAK(3), DGAT1(4), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKI(5), DGKQ(1), DGKZ(2), GK(1), GK2(1), GLA(1), GLB1(3), GPAM(5), LCT(6), LIPA(1), LIPC(2), LIPF(2), LIPG(2), LPL(1), MGLL(4), PNLIP(1), PNLIPRP1(3), PNPLA3(1), PPAP2A(3), PPAP2B(1), PPAP2C(2)	33927171	107	70	106	33	2	24	17	33	31	0	0.680	1.000	1.000
532	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(10), ACACB(10), ACAT1(2), ACAT2(5), ACOT12(5), ACSS1(2), ACSS2(1), ACYP1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), DLD(4), GLO1(2), HAGH(1), HAGHL(4), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(1), ME2(3), ME3(1), PC(3), PCK1(6), PCK2(1), PDHA1(1), PDHA2(3), PDHB(2), PKLR(3)	26181407	88	68	88	26	7	22	9	29	20	1	0.476	1.000	1.000
533	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASS(5), ACAT1(2), ACAT2(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(7), ECHS1(2), EHHADH(10), EHMT1(4), EHMT2(5), GCDH(1), HADH(1), HADHA(3), HSD17B4(1), HSD3B7(1), NSD1(8), OGDH(1), OGDHL(3), PLOD1(1), PLOD2(6), PLOD3(1), RDH11(1), RDH13(1), RDH14(1), SETD1A(6), SETDB1(3), SHMT1(2), SHMT2(4), SPCS3(2), SUV39H1(1), SUV39H2(3)	32753892	104	66	103	29	5	25	16	29	29	0	0.401	1.000	1.000
534	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(1), ACYP1(1), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GAPDHS(2), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(2), PFKL(1), PFKM(1), PFKP(2), PGAM4(1), PGK2(2), PGM1(1), PGM3(2), PKLR(3), TPI1(1)	32698784	82	63	81	31	5	15	10	28	24	0	0.849	1.000	1.000
535	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(2), ACADM(1), ACADVL(2), ACAT1(2), ACAT2(5), ACOX1(2), ACOX3(1), ACSL1(1), ACSL3(2), ACSL5(1), ACSL6(3), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CPT1A(4), CPT1B(4), CPT2(1), CYP4A11(3), CYP4A22(5), ECHS1(2), EHHADH(10), GCDH(1), HADH(1), HADHA(3), HADHB(4), HSD17B4(1)	27574408	83	60	83	24	1	20	11	30	21	0	0.455	1.000	1.000
536	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(2), AKT2(3), AKT3(2), ARHGEF11(6), BCL2(1), CDC42(3), DLG4(3), GNA13(1), LPA(5), MAP2K4(4), MAP3K1(3), MAP3K5(1), MAPK8(1), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(5), PLD1(4), PLD2(3), PLD3(4), PTK2(9), RDX(1), ROCK1(6), ROCK2(3), SERPINA4(2), SRF(1)	28988387	85	60	83	27	3	23	12	21	26	0	0.717	1.000	1.000
537	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(5), CDT1(1), DIAPH2(2), GMNN(1), MCM10(7), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), NACA(5), POLD1(4), POLD4(1), POLE(4), POLE2(4), PRIM1(3), RFC1(7), RFC2(5), RFC4(1), RFC5(2), RPA1(1), RPA2(2), RPS27A(1), UBA52(1), UBC(1)	28794673	81	58	78	21	6	15	8	32	20	0	0.271	1.000	1.000
538	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(1), B3GALT1(1), B3GALT4(1), B3GALT5(2), B3GNT1(1), B3GNT2(1), B3GNT4(2), B3GNT5(1), B4GALNT1(1), B4GALT2(1), B4GALT3(2), B4GALT6(2), FUT1(4), FUT3(2), FUT5(1), FUT7(2), FUT9(4), GBGT1(3), GCNT2(1), PIGA(1), PIGB(1), PIGC(2), PIGL(2), PIGM(4), PIGN(6), PIGO(2), PIGQ(3), PIGS(5), PIGV(2), PIGZ(4), ST3GAL1(1), ST3GAL2(1), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC5(3), ST8SIA5(2)	27880022	76	58	76	22	7	12	9	31	17	0	0.562	1.000	1.000
539	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLB(2), POLD1(4), POLD4(1), POLE(4), POLE2(4), POLE3(1), POLG(5), POLG2(2), POLI(1), POLK(2), POLL(1), POLM(1), POLQ(17), PRIM1(3), REV1(6), REV3L(13), RFC5(2)	23426387	73	57	72	23	4	19	6	24	20	0	0.587	1.000	1.000
540	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(9), BMPR1B(2), CCND2(3), CDKN1B(5), DAZL(1), ESR2(1), FSHR(4), GJA4(1), INHA(2), LHCGR(6), MLH1(2), MSH5(3), NCOR1(10), NR5A1(2), NRIP1(1), PGR(5), PRLR(1), PTGER2(3), SMPD1(4), ZP2(2)	19572694	67	57	65	20	8	11	4	25	17	2	0.600	1.000	1.000
541	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(4), EGF(6), EGFR(6), MAPK1(3), PTPRB(14), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SPRY1(3), SPRY2(3), SPRY3(1), SPRY4(1), SRC(3)	14144379	67	57	66	22	3	16	9	23	15	1	0.765	1.000	1.000
542	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH9A1(1), ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(2), PFKM(1), PFKP(2), PGM1(1), PGM3(2), PKLR(3), TPI1(1)	27366083	68	56	68	28	4	13	8	24	19	0	0.891	1.000	1.000
543	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), CEL(3), DGAT1(4), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKQ(1), DGKZ(2), GK(1), GLA(1), GLB1(3), LCT(6), LIPC(2), LIPF(2), LIPG(2), LPL(1), PNLIP(1), PNLIPRP1(3), PPAP2A(3), PPAP2B(1), PPAP2C(2)	28001003	83	56	82	22	2	19	14	25	23	0	0.376	1.000	1.000
544	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH9A1(1), ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(2), PFKM(1), PFKP(2), PGM1(1), PGM3(2), PKLR(3), TPI1(1)	27366083	68	56	68	28	4	13	8	24	19	0	0.891	1.000	1.000
545	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTR2(1), AKT1(2), ANGPTL2(1), CDC42(3), CFL1(1), CFL2(2), FLNA(4), FLNC(5), FSCN1(1), GDI2(3), LIMK1(4), MYH2(7), MYLK(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), RHO(3), ROCK1(6), ROCK2(3), VASP(2), WASF1(1), WASL(2)	27449486	80	56	80	33	7	16	6	32	19	0	0.969	1.000	1.000
546	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(3), ARSE(2), ASAH1(2), B4GALT6(2), DEGS1(1), ENPP7(1), GALC(3), GLA(1), GLB1(3), LCT(6), NEU1(2), NEU2(4), NEU3(2), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(2), SGMS1(4), SGMS2(1), SGPP1(1), SGPP2(2), SMPD1(4), SMPD2(4), SMPD3(1), SMPD4(3), SPHK1(7), SPHK2(3), SPTLC2(1)	20373997	71	55	68	22	7	20	14	15	15	0	0.394	1.000	1.000
547	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(1), ABAT(3), ACAT1(2), ACAT2(5), ACSM1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH5A1(1), ALDH7A1(1), ALDH9A1(1), BDH1(2), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADH(1), HADHA(3), HMGCL(2), HMGCS1(2), HMGCS2(2), HSD17B4(1), HSD3B7(1), L2HGDH(2), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(2), PLA1A(2), PRDX6(1), RDH11(1), RDH13(1), RDH14(1)	23301268	75	55	74	28	4	19	8	28	16	0	0.808	1.000	1.000
548	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GAPDHS(2), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHAL6B(2), LDHB(1), LDHC(1), MDH1(1), PC(3), PCK1(6), PDHA1(1), PDHA2(3), PDHB(2), PDHX(3), PFKL(1), PFKM(1), PFKP(2), PGK2(2), PKLR(3), TPI1(1)	23589659	62	52	61	27	5	13	8	20	15	1	0.925	1.000	1.000
549	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), BLVRA(1), COX10(1), CP(6), CPOX(1), EPRS(4), FECH(1), FTMT(5), GUSB(8), HCCS(2), HMBS(4), HMOX1(1), PPOX(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5)	22757490	67	52	65	19	1	12	3	23	28	0	0.842	1.000	1.000
550	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(1), FBP1(1), FBP2(2), FPGT(3), FUK(2), GMPPA(5), GMPPB(1), HK1(3), HK2(3), HK3(5), HSD3B7(1), LHPP(1), MPI(2), MTMR1(2), MTMR2(1), MTMR6(4), PFKFB1(5), PFKFB2(3), PFKFB3(2), PFKFB4(1), PFKL(1), PFKM(1), PFKP(2), PGM2(3), PHPT1(1), PMM1(1), RDH11(1), RDH13(1), RDH14(1), SORD(1), TPI1(1), TSTA3(3)	21381540	66	51	65	25	5	14	8	22	17	0	0.810	1.000	1.000
551	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), CYP19A1(1), CYP1A1(3), CYP2A13(2), CYP2A6(3), CYP2A7(4), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2D6(1), CYP2E1(4), CYP2F1(1), CYP3A4(1), CYP3A5(4), CYP4B1(6), PON1(1)	16707965	62	49	62	19	2	18	5	19	18	0	0.696	1.000	1.000
552	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(3), CARS(2), CARS2(1), DARS(1), EPRS(4), FARS2(1), FARSA(2), FARSB(1), GARS(1), HARS(1), HARS2(1), IARS(5), IARS2(3), LARS(1), LARS2(2), MARS(6), MTFMT(1), NARS2(2), PARS2(1), QARS(1), RARS(3), RARS2(1), SARS2(2), TARS(2), TARS2(4), VARS(2), VARS2(1), WARS(2), WARS2(1)	30380376	61	49	61	29	2	17	4	14	24	0	0.996	1.000	1.000
553	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), FUCA1(1), FUCA2(1), GALNS(1), GLB1(3), GUSB(8), HEXA(3), HEXB(1), HGSNAT(4), HPSE(1), HPSE2(2), HYAL1(1), IDS(1), IDUA(1), LCT(6), MAN2B1(2), MAN2B2(3), MAN2C1(5), MANBA(1), NAGLU(3), NEU1(2), NEU2(4), NEU3(2), NEU4(2), SPAM1(4)	20371972	64	49	61	21	6	14	11	19	14	0	0.483	1.000	1.000
554	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(9), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(1), EIF2AK1(1), EIF2AK2(1), EIF2AK3(3), EIF2B2(2), EIF2B3(2), EIF2B4(1), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF4A2(3), EIF4EBP2(1), EIF4G1(7), EIF4G3(6), EIF5(1), EIF5A(2), EIF5B(1), ETF1(1), PABPC3(3), SLC35A4(1)	25166782	54	49	53	21	5	15	10	12	11	1	0.820	1.000	1.000
555	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	21	F10(3), F11(1), F12(1), F13B(1), F2(2), F5(7), F8(5), FGA(12), FGB(3), LPA(5), PLAT(2), PLG(3), SERPINB2(3), SERPINE1(1), VWF(7)	20342162	56	47	55	20	1	19	12	14	10	0	0.643	1.000	1.000
556	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT2(1), FBP2(2), G6PC(3), GAA(2), GALK1(3), GALK2(1), GANAB(3), GLA(1), GLB1(3), HK1(3), HK2(3), HK3(5), LCT(6), MGAM(9), PFKM(1), PFKP(2), PGM1(1), PGM3(2)	18379069	52	47	50	21	4	11	8	18	11	0	0.800	1.000	1.000
557	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), B4GALT2(1), G6PC(3), GAA(2), GALK1(3), GALK2(1), GLA(1), GLB1(3), HK1(3), HK2(3), HK3(5), HSD3B7(1), LCT(6), MGAM(9), PFKL(1), PFKM(1), PFKP(2), PGM1(1), PGM3(2), RDH11(1), RDH13(1), RDH14(1), UGP2(3)	21793829	55	47	53	27	5	11	8	18	13	0	0.965	1.000	1.000
558	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), AARS2(3), ABAT(3), ACY3(1), ADSL(2), ADSS(2), AGXT(3), AGXT2(1), ASL(1), ASNS(3), ASRGL1(1), ASS1(3), CAD(4), CRAT(2), DARS(1), DLD(4), GAD1(5), GAD2(1), GPT(1), GPT2(2), NARS2(2), PC(3), PDHA1(1), PDHA2(3), PDHB(2)	21482296	57	47	57	22	5	19	9	17	7	0	0.748	1.000	1.000
559	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(1), ARHGAP4(2), ARHGAP5(3), ARHGAP6(2), ARHGEF1(1), ARHGEF11(6), ARHGEF5(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), BAIAP2(1), CFL1(1), DIAPH1(5), GSN(2), LIMK1(4), MYLK(3), PIP5K1B(1), PPP1R12B(4), ROCK1(6), SRC(3), TLN1(10), VCL(3)	27198006	67	47	67	18	3	15	7	24	18	0	0.507	1.000	1.000
560	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(2), ACADM(1), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH9A1(1), AOX1(11), BCAT1(2), BCKDHA(1), ECHS1(2), EHHADH(10), HADHA(3), HADHB(4), HIBADH(1), HMGCL(2), IVD(1), MCCC1(5), MCCC2(2), MUT(4), OXCT1(2), PCCA(1), PCCB(1), SDS(2)	20505019	74	47	73	25	0	22	7	25	20	0	0.743	1.000	1.000
561	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(8), EGR2(1), EGR3(2), GNAQ(1), MAP3K1(3), MYC(2), NFATC1(2), NFATC2(7), NFKB1(3), NFKBIA(2), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RELA(4), SYT1(2), VIPR2(2)	15696890	60	46	59	19	5	13	5	23	14	0	0.815	1.000	1.000
562	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(9), AGT(1), EDN1(2), EDNRA(1), EDNRB(2), EGF(6), EGFR(6), FOS(1), JUN(2), MYC(2), NFKB1(3), PLCG1(7), PRKCA(1), RELA(4)	11446894	47	44	45	15	2	13	6	12	14	0	0.762	1.000	1.000
563	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(3), GRIN1(5), GRIN2A(6), GRIN2B(3), GRIN2C(5), GRIN2D(2), NOS1(14), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), SYT1(2)	14734754	55	44	54	22	5	15	6	20	9	0	0.913	1.000	1.000
564	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(3), CMAS(1), CTBS(1), CYB5R3(1), GFPT1(1), GFPT2(2), GNE(2), GNPDA2(2), GNPNAT1(1), HEXA(3), HEXB(1), HK1(3), HK2(3), HK3(5), LHPP(1), MTMR1(2), MTMR2(1), MTMR6(4), NAGK(3), NANS(1), NPL(1), PGM3(2), PHPT1(1), UAP1(1)	16325440	46	42	46	22	2	9	5	17	13	0	0.951	1.000	1.000
565	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR7(2), CD4(1), CXCR3(3), CXCR4(2), IFNG(3), IFNGR1(3), IFNGR2(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL18R1(2), IL4(1), IL4R(1), IL5(1), TGFB1(1), TGFB2(4), TGFB3(2)	11361878	52	42	52	17	3	14	4	25	6	0	0.643	1.000	1.000
566	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(8), CREBBP(6), EP300(11), FADD(1), IKBKB(4), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2)	13052823	48	41	47	17	0	18	4	18	8	0	0.807	1.000	1.000
567	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(3), GTF2B(3), GTF2E1(3), GTF2H4(3), POLR1A(7), POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3B(2), POLR3D(2), POLR3E(2), POLR3H(1), TAF6(4), TBP(1)	19943989	52	40	51	14	3	14	6	11	18	0	0.295	1.000	1.000
568	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(3), ARSE(2), ASAH1(2), GALC(3), GLA(1), GLB1(3), LCT(6), NEU1(2), NEU2(4), NEU3(2), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(2), SMPD1(4), SMPD2(4), SPTLC2(1)	13840982	45	39	43	20	3	13	9	11	9	0	0.864	1.000	1.000
569	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(10), ACACB(10), FASN(18), MCAT(2), OXSM(3)	9366085	43	39	43	15	5	9	6	15	8	0	0.639	1.000	1.000
570	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(2), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(4), CYP7A1(1), HADHB(4), HSD3B7(1), LIPA(1), RDH11(1), RDH13(1), RDH14(1), SLC27A5(3), SOAT2(1), SRD5A1(1)	18095693	51	39	51	17	6	13	4	18	10	0	0.632	1.000	1.000
571	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	29	ANXA1(1), ANXA2(1), ANXA3(4), ANXA6(1), CYP11A1(1), EDN1(2), EDNRA(1), EDNRB(2), HPGD(3), HSD11B1(2), PLA2G4A(8), PRL(3), PTGER1(1), PTGER2(3), PTGER4(1), PTGFR(2), PTGIR(2), PTGIS(2), PTGS1(2), PTGS2(3)	12525829	45	39	43	14	5	7	5	18	10	0	0.646	1.000	1.000
572	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(3), ALDH4A1(1), ALDH5A1(1), CAD(4), CPS1(12), EPRS(4), GAD1(5), GAD2(1), GCLC(1), GCLM(1), GFPT1(1), GLS(4), GLS2(1), GLUD1(3), GLUL(1), GMPS(4), GPT(1), GPT2(2), GSS(1), PPAT(4), QARS(1)	18871065	56	38	55	16	2	16	5	15	18	0	0.514	1.000	1.000
573	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(10), C5(5), C6(1), C7(1), ICAM1(1), IL6(2), ITGA4(5), ITGAL(5), ITGB2(8), SELP(1), SELPLG(1), TNF(1), VCAM1(3)	13872000	44	38	43	19	2	13	3	14	12	0	0.919	1.000	1.000
574	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1QA(3), C2(4), C3(10), C4A(2), C4B(1), C5(5), C6(1), C7(1), C8A(4), C8B(4), C9(2), MASP1(2)	19299824	39	36	39	13	3	10	5	8	13	0	0.673	1.000	1.000
575	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1QA(3), C2(4), C3(10), C4A(2), C4B(1), C5(5), C6(1), C7(1), C8A(4), C9(2), MASP1(2), MASP2(3), MBL2(1)	19684768	39	36	39	15	3	8	6	7	15	0	0.864	1.000	1.000
576	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(1), FBP1(1), FBP2(2), FPGT(3), GMPPA(5), GMPPB(1), HK1(3), HK2(3), HK3(5), MPI(2), PFKFB1(5), PFKFB3(2), PFKFB4(1), PFKM(1), PFKP(2), PMM1(1), SORD(1), TPI1(1)	13690096	41	36	41	16	3	7	8	13	10	0	0.708	1.000	1.000
577	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(1), GLB1(3), GUSB(8), HEXA(3), HEXB(1), HGSNAT(4), HPSE(1), HPSE2(2), HYAL1(1), IDS(1), IDUA(1), LCT(6), NAGLU(3), SPAM1(4)	12075355	39	34	36	14	2	7	9	12	9	0	0.538	1.000	1.000
578	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(3), ADSL(2), ADSS(2), AGXT(3), AGXT2(1), ASL(1), ASNS(3), CAD(4), CRAT(2), DARS(1), GAD1(5), GAD2(1), GPT(1), GPT2(2), PC(3)	14728794	37	33	37	15	3	13	5	11	5	0	0.851	1.000	1.000
579	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(2), DARS(1), EPRS(4), FARS2(1), GARS(1), HARS(1), IARS(5), LARS(1), LARS2(2), MARS(6), QARS(1), RARS(3), TARS(2), WARS(2), WARS2(1)	17773423	36	33	36	13	1	12	2	7	14	0	0.814	1.000	1.000
580	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT2(1), B3GAT3(1), B4GALT7(1), CHPF(5), CHST11(2), CHST12(2), CHST13(3), CHST14(1), CHST3(5), CHST7(2), CHSY1(2), DSE(6), UST(3), XYLT1(3), XYLT2(1)	8256362	39	33	39	14	4	5	4	18	8	0	0.794	1.000	1.000
581	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(3), BCL2(1), CASP8(1), FADD(1), MAP2K4(4), MAP3K1(3), MAPK1(3), MAPK8(1), NFKB1(3), NSMAF(3), RAF1(2), RELA(4), RIPK1(4), SMPD1(4), TNFRSF1A(1)	11557898	38	32	36	15	3	9	4	11	11	0	0.918	1.000	1.000
582	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(4), EXTL1(2), EXTL3(2), GLCE(2), HS2ST1(3), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST5(4), HS6ST2(1), HS6ST3(1), NDST1(2), NDST2(2), NDST3(4), NDST4(6)	11948998	39	31	39	18	4	14	1	13	7	0	0.958	1.000	1.000
583	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(2), CD3G(1), CD4(1), CXCR3(3), IFNG(3), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), JAK2(4), STAT4(4), TYK2(1)	8440895	35	31	35	13	2	7	4	16	6	0	0.797	1.000	1.000
584	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1QA(3), C2(4), C3(10), C4A(2), C4B(1), C5(5), C6(1), C7(1), C8A(4), C9(2)	17475943	33	30	33	11	3	7	4	6	13	0	0.701	1.000	1.000
585	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(4), POLE(4), POLG(5), POLL(1), POLQ(17)	9491775	33	30	33	12	3	7	4	11	8	0	0.807	1.000	1.000
586	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), CSF1R(1), EGF(6), EGFR(6), MET(2), PDGFRA(5), PRKCA(1), SH3GLB1(2), SH3KBP1(1), SRC(3)	10925246	31	29	30	11	1	7	4	9	10	0	0.841	1.000	1.000
587	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(5), CHAT(4), DDC(2), GAD1(5), GAD2(1), HDC(4), MAOA(1), PAH(2), TH(1), TPH1(2)	8163571	29	28	29	12	4	3	4	11	7	0	0.760	1.000	1.000
588	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(4), GRM1(4), PLCB1(8), PPP1CA(2), PPP1R1B(1), PPP2CA(2), PPP3CA(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3)	9054449	33	28	33	11	4	9	3	12	5	0	0.646	1.000	1.000
589	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ENPP1(1), ENPP3(4), FLAD1(2), LHPP(1), MTMR1(2), MTMR2(1), MTMR6(4), PHPT1(1), RFK(1), TYR(5)	8571573	33	28	33	12	1	7	5	14	6	0	0.848	1.000	1.000
590	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(6), EP300(11), LPL(1), NCOA1(5), NCOA2(5), PPARG(1), RXRA(2)	10256894	31	28	29	10	0	8	3	13	7	0	0.706	1.000	1.000
591	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(8), DUSP1(1), IKBKAP(5), IKBKB(4), MAP3K1(3), NFKB1(3), NFKBIA(2), RELA(4), TNFAIP3(1), TRAF3(1), TRAF6(2)	10780405	34	27	34	11	0	10	5	12	7	0	0.762	1.000	1.000
592	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(6), EPOR(1), GRIN1(5), HIF1A(3), JAK2(4), NFKB1(3), NFKBIA(2), RELA(4)	7406097	30	27	29	10	0	4	2	16	8	0	0.924	1.000	1.000
593	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(1), IFNB1(2), IFNG(3), IL10(1), IL12A(6), IL12B(2), IL4(1), IL5(1), IL6(2), IL7(1), PDGFA(2), TGFB1(1), TGFB2(4), TGFB3(2), TNF(1)	7741068	34	27	34	11	1	7	3	19	4	0	0.719	1.000	1.000
594	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ICAM1(1), ITGA4(5), ITGAL(5), ITGAM(6), ITGB2(8), SELE(1), SELP(1)	9136102	31	27	30	13	2	10	2	11	6	0	0.915	1.000	1.000
595	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(4), CSF1(2), IL1B(1), IL6R(3), SPN(3), TGFB1(1), TGFB2(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF8(3), TNFSF8(1)	7982061	29	27	29	12	2	9	2	10	6	0	0.872	1.000	1.000
596	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(1), ELOVL2(1), ELOVL5(1), FASN(18), HADHA(3), PECR(3), SCD(2)	8718770	31	26	31	16	3	8	3	12	5	0	0.956	1.000	1.000
597	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(3), ANKRD1(4), ATF3(3), DUSP14(1), IFNG(3), IFRD1(2), IL18(2), IL1R1(4), JUND(1), MYOG(1), NR4A3(2), WDR1(3)	6255574	29	26	27	15	1	7	3	6	12	0	0.962	1.000	1.000
598	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), DERA(1), FBP1(1), FBP2(2), G6PD(1), GPI(1), H6PD(5), PFKL(1), PFKM(1), PFKP(2), PGLS(2), PGM1(1), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TALDO1(1), TKT(1), TKTL1(1), TKTL2(3)	13758186	30	25	29	16	2	7	2	12	7	0	0.953	1.000	1.000
599	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CYP2C9(3), DHRS1(1), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(10), ESCO1(2), ESCO2(3), HADHA(3), NAT6(1), PNPLA3(1), SH3GLB1(2)	17286606	38	25	38	11	1	10	5	17	5	0	0.382	1.000	1.000
600	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(2), IMPDH1(1), MTHFD2(2), NME2(1), POLB(2), POLD1(4), POLG(5), RRM1(5), SRM(2)	7414094	26	25	25	10	3	8	1	7	7	0	0.754	1.000	1.000
601	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(5), ADRB2(3), GNAS(10), PLCE1(5), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTGER1(1)	8643494	32	25	29	10	6	9	3	10	4	0	0.626	1.000	1.000
602	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(1), GFPT1(1), GNE(2), GNPDA2(2), HEXA(3), HEXB(1), HK1(3), HK2(3), HK3(5), PGM3(2), UAP1(1)	9695540	25	24	25	13	1	5	4	7	8	0	0.866	1.000	1.000
603	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(5), IARS2(3), LARS(1), LARS2(2), PDHA1(1), PDHA2(3), PDHB(2), VARS(2), VARS2(1)	10450689	23	22	23	11	1	7	1	8	6	0	0.954	1.000	1.000
604	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(8), MAP2(6), PPP1CA(2), PPP2CA(2), PRKACB(2), PRKACG(2), PRKAR2B(3)	9417506	25	21	25	10	1	6	0	9	9	0	0.948	1.000	1.000
605	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(10), C5(5), C6(1), C7(1), C8A(4), C9(2)	7140154	23	21	23	10	2	6	2	3	10	0	0.857	1.000	1.000
606	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), BAIAP2(1), CASP3(3), CASP8(1), INS(1), INSR(4), ITCH(1), MAGI1(1), MAGI2(6), RERE(3), WWP1(3), WWP2(1)	13367140	27	21	27	13	1	4	6	9	6	1	0.951	1.000	1.000
607	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ICAM1(1), ITGA4(5), ITGAL(5), ITGB2(8), SELE(1)	6871480	24	21	23	11	1	9	1	9	4	0	0.913	1.000	1.000
608	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(1), GALNT3(2), GALNT4(4), GALNT7(1), GALNT8(2), GALNT9(1), ST3GAL1(1), ST3GAL2(1), WBSCR17(7)	8309821	22	21	22	10	4	2	3	9	4	0	0.872	1.000	1.000
609	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT1(2), ACAT2(5), ECHS1(2), EHHADH(10), HADHA(3), HADHB(4), SDS(2)	4771563	29	20	29	10	0	7	5	12	5	0	0.628	1.000	1.000
610	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), FBP1(1), FBP2(2), G6PD(1), GPI(1), H6PD(5), PFKM(1), PFKP(2), PGLS(2), PGM1(1), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TALDO1(1), TKT(1)	11379836	24	20	23	15	2	7	0	8	7	0	0.981	1.000	1.000
611	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(8), MAPK14(3), MAPK8(1), NFKB1(3), RELA(4), TNFSF13B(1), TRAF3(1), TRAF5(2), TRAF6(2)	8169182	25	20	25	10	1	6	5	6	7	0	0.875	1.000	1.000
612	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), FBP1(1), FBP2(2), GPT(1), GPT2(2), MDH1(1), ME1(1), ME3(1), PGK2(2), PKLR(3), TKT(1), TKTL1(1), TKTL2(3), TPI1(1)	11409570	21	18	20	14	2	4	2	12	1	0	0.980	1.000	1.000
613	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(3), IFNAR1(2), IFNAR2(1), IFNB1(2), MAPK8(1), NFKB1(3), RELA(4), TNFRSF11A(1), TNFSF11(1), TRAF6(2)	6163089	21	17	21	10	2	6	1	7	5	0	0.912	1.000	1.000
614	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), FBP1(1), FBP2(2), GPT(1), GPT2(2), MDH1(1), ME1(1), ME2(3), ME3(1), PKLR(3), TKT(1), TPI1(1)	10237912	18	16	18	12	2	6	1	8	1	0	0.970	1.000	1.000
615	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(2), CD3G(1), CD4(1)	1810563	4	3	4	3	0	3	0	1	0	0	0.926	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		842079	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
