rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(65), CDC25A(5), CDC25B(2), CDC25C(2), CDK2(1), CDK4(5), CHEK1(3), MYT1(10), RB1(73), TP53(226), WEE1(10), YWHAH(2) 10260649 404 252 286 32 111 10 93 32 149 9 2.45e-11 <1.00e-15 <1.54e-13 2 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), HSPA1A(3), IFNG(2), IFNGR1(1), IFNGR2(6), IKBKB(11), JAK2(8), LIN7A(3), NFKB1(3), NFKBIA(6), RB1(73), RELA(6), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TP53(226), USH1C(4), WT1(4) 10415274 374 235 257 31 110 7 88 21 140 8 1.98e-13 <1.00e-15 <1.54e-13 3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF3(1), CCND1(4), CDK2(1), CDK4(5), CDKN1A(38), CDKN1B(6), CDKN2A(30), CFL1(1), E2F1(3), E2F2(4), MDM2(6), PRB1(2), TP53(226) 4836827 327 232 202 25 88 7 93 18 114 7 2.19e-12 <1.00e-15 <1.54e-13 4 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(7), DNAJC3(6), EIF2S1(5), EIF2S2(1), NFKB1(3), NFKBIA(6), RELA(6), TP53(226) 5652096 260 206 152 13 82 5 81 17 73 2 2.19e-13 <1.00e-15 <1.54e-13 5 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(65), ATR(32), CDC25C(2), CHEK1(3), CHEK2(11), TP53(226), YWHAH(2) 9369284 341 240 229 22 113 10 92 34 88 4 1.12e-10 1.33e-15 1.64e-13 6 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(4), CCNE1(3), CDC34(1), CDK2(1), CUL1(19), E2F1(3), RB1(73), SKP2(5), TFDP1(2) 4966858 111 101 99 9 29 1 8 5 62 6 0.000161 2.00e-15 2.05e-13 7 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(9), ATM(65), ATR(32), CCNA1(4), CCND1(4), CCNE1(3), CDC25A(5), CDK2(1), CDK4(5), CDK6(5), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(2), E2F1(3), GSK3B(4), HDAC1(4), RB1(73), SKP2(5), TFDP1(2), TGFB1(2), TGFB3(1), TP53(226) 17514723 529 279 392 43 155 15 112 39 193 15 8.33e-15 2.33e-15 2.05e-13 8 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(9), CDKN2A(30), E2F1(3), MDM2(6), MYC(2), PIK3CA(94), PIK3R1(6), POLR1A(18), POLR1B(4), POLR1C(5), POLR1D(4), RAC1(4), RB1(73), TBX2(7), TP53(226) 11787713 491 271 308 38 181 13 102 37 150 8 <1.00e-15 2.66e-15 2.05e-13 9 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(7), ATM(65), BAX(1), CCND1(4), CCNE1(3), CDK2(1), CDK4(5), CDKN1A(38), E2F1(3), GADD45A(1), MDM2(6), PCNA(4), RB1(73), TP53(226) 10569238 437 266 310 31 116 9 95 30 173 14 1.45e-12 3.00e-15 2.05e-13 10 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(4), MYC(2), SP1(10), SP3(3), TP53(226), WT1(4) 4101874 249 205 141 21 69 6 80 21 71 2 3.73e-09 3.77e-15 2.33e-13 11 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(50), DAXX(9), HRAS(16), PAX3(8), PML(7), RARA(4), RB1(73), SIRT1(9), SP100(13), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TP53(226) 10972480 430 256 303 32 110 5 122 30 154 9 <1.00e-15 4.33e-15 2.42e-13 12 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(16), AKT1(3), ATM(65), BAX(1), CDKN1A(38), CPB2(5), CSNK1A1(6), CSNK1D(3), FHL2(1), GADD45A(1), HIF1A(6), HSPA1A(3), IGFBP3(1), MAPK8(5), MDM2(6), NFKBIB(6), TP53(226) 12077203 392 261 272 38 121 11 101 32 119 8 8.51e-09 5.44e-15 2.79e-13 13 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDC34(1), CDK2(1), CUL1(19), E2F1(3), FBXW7(35), RB1(73), TFDP1(2) 4802111 137 117 115 8 33 1 18 5 74 6 1.89e-06 6.00e-15 2.84e-13 14 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(4), CCNB1(5), CCND1(4), CCND2(1), CCND3(5), CCNE1(3), CCNH(4), CDC25A(5), CDK2(1), CDK4(5), CDK6(5), CDK7(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(2), CDKN2C(2), CDKN2D(1), E2F1(3), RB1(73), RBL1(9), TFDP1(2) 9246340 214 157 189 22 57 6 22 9 109 11 0.000127 1.48e-11 6.52e-10 15 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDK2(1), CDKN1B(6), CUL1(19), E2F1(3), NEDD8(2), RB1(73), RBX1(1), SKP2(5), TFDP1(2), UBE2M(3) 4996097 118 100 106 13 32 1 8 6 65 6 0.00153 2.00e-08 8.22e-07 16 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCND1(4), CCNE1(3), CDK2(1), CDK4(5), CDK6(5), CDKN1A(38), CDKN1B(6), E2F1(3), HRAS(16), MAPK3(8), NFKB1(3), NFKBIA(6), PAK1(4), PIK3CA(94), PIK3R1(6), RAC1(4), RAF1(4), RB1(73), RELA(6), TFDP1(2) 11750042 294 204 212 32 124 7 29 24 99 11 5.55e-07 7.98e-06 0.000307 17 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(7), ATM(65), BAD(2), BAX(1), BCL2L1(4), BID(2), CASP3(3), CASP6(1), CASP7(5), CASP9(6), CYCS(1), EIF2S1(5), PRKCA(3), PTK2(12), PXN(3), STAT1(13), TLN1(17), TP53(226) 15945862 379 249 266 41 131 13 103 31 98 3 1.66e-09 3.14e-05 0.00114 18 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(5), CDC25B(2), CDK7(6), CDKN1A(38), CHEK1(3), NEK1(5), WEE1(10) 3964352 69 57 61 8 24 5 3 0 32 5 0.415 5.43e-05 0.00186 19 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(2), NFYB(1), NFYC(1), RB1(73), SP1(10), SP3(3) 3897027 90 81 83 12 12 2 1 6 63 6 0.0694 0.000101 0.00328 20 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(9), ATM(65), BRCA1(23), CDKN1A(38), CHEK1(3), CHEK2(11), GADD45A(1), JUN(4), MAPK8(5), MDM2(6), MRE11A(7), NFKB1(3), NFKBIA(6), RAD50(13), RAD51(7), RBBP8(10), RELA(6), TP53(226), TP73(6) 17377980 449 276 326 40 163 10 107 34 127 8 2.06e-09 0.000152 0.00468 21 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), EGFR(7), IGF1R(11), MYC(2), POLR2A(13), PPP2CA(2), PRKCA(3), RB1(73), TEP1(14), TERF1(5), TERT(4), TNKS(6), TP53(226), XRCC5(1) 16355141 370 235 255 48 97 6 102 24 133 8 3.71e-09 0.00120 0.0351 22 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(9), GH1(3), GHR(6), HRAS(16), IGF1(2), IGF1R(11), PIK3CA(94), PIK3R1(6), SHC1(8), SOD1(4), SOD2(1), SOD3(1) 7753212 164 134 99 22 93 3 36 22 10 0 5.21e-05 0.00196 0.0535 23 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(4), AKT3(6), CDKN1A(38), ELK1(1), GRB2(1), HRAS(16), MAP2K1(3), MAP2K2(5), NGFR(4), NTRK1(6), PIK3CA(94), PIK3CD(7), SHC1(8), SOS1(23) 9361623 219 157 145 29 119 4 34 24 33 5 2.54e-05 0.00200 0.0535 24 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), CDC42(4), PAK1(4), PDGFRA(16), PIK3CA(94), PIK3R1(6), RAC1(4), WASL(2) 7841607 150 125 91 16 95 5 15 19 16 0 5.31e-05 0.00555 0.143 25 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(50), EP300(77), ESR1(5), MAPK3(8), PELP1(5), SRC(5) 8473831 150 120 142 22 46 6 27 17 52 2 0.00182 0.0409 1.000 26 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(3), CD3E(2), CD3G(2), CD80(2), CD86(6), CTLA4(1), GRB2(1), HLA-DRA(4), HLA-DRB1(1), ICOS(2), IL2(1), ITK(6), LCK(2), PIK3CA(94), PIK3R1(6), PTPN11(4) 7502326 137 112 78 17 89 4 17 21 6 0 0.000172 0.128 1.000 27 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), BAD(2), CHRNB1(6), CHRNG(2), MUSK(9), PIK3CA(94), PIK3R1(6), PTK2(12), PTK2B(6), RAPSN(2), SRC(5), TERT(4), YWHAH(2) 9421423 153 122 94 21 94 10 19 19 11 0 1.20e-05 0.137 1.000 28 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), BAD(2), CASP9(6), CHUK(7), GH1(3), GHR(6), NFKB1(3), NFKBIA(6), PDPK1(2), PIK3CA(94), PIK3R1(6), PPP2CA(2), RELA(6), YWHAH(2) 8186059 148 115 89 18 99 7 15 16 11 0 0.000313 0.192 1.000 29 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(8) 1005449 8 8 8 0 3 0 3 0 2 0 0.130 0.467 1.000 30 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(7), CYP2C9(3) 1188571 10 10 10 2 3 0 6 0 1 0 0.372 0.561 1.000 31 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(65), ATR(32), BRCA1(23), CCNB1(5), CDC25A(5), CDC25B(2), CDC25C(2), CDC34(1), CDKN1A(38), CDKN2D(1), CHEK1(3), CHEK2(11), EP300(77), GADD45A(1), MDM2(6), MYT1(10), PRKDC(35), RPS6KA1(5), TP53(226), WEE1(10), YWHAH(2), YWHAQ(3) 24351420 563 290 438 59 195 21 125 52 160 10 2.56e-10 0.682 1.000 32 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(10), NR0B2(2), NR1H3(3), NR1H4(4), RXRA(25) 3161192 45 40 32 9 22 3 9 2 9 0 0.0560 0.711 1.000 33 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), NFS1(5), THTPA(2), TPK1(4) 3725882 35 32 35 4 21 0 5 5 4 0 0.0696 0.742 1.000 34 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4) 3308380 25 24 25 3 11 1 6 2 5 0 0.0653 0.748 1.000 35 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(94), PIK3R1(6), PLCB1(16), PLCG1(12), PRKCA(3), VAV1(8) 7511540 142 120 83 21 97 4 18 17 6 0 0.000929 0.750 1.000 36 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(3), FMOD(3), KERA(7), LUM(2) 2112006 17 16 17 2 9 0 5 2 1 0 0.0853 0.773 1.000 37 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 299386 1 1 1 0 1 0 0 0 0 0 0.748 0.780 1.000 38 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(4), AKT3(6), BPNT1(2), GRB2(1), ILK(3), MAPK3(8), PDK1(2), PIK3CA(94), PIK3CD(7), PTEN(16), PTK2B(6), RBL2(9), SHC1(8), SOS1(23) 11890301 192 148 131 27 124 6 22 23 17 0 5.15e-05 0.804 1.000 39 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(9), IFNG(2), IL12A(1), IL12B(3), IL2(1) 1737741 16 16 16 3 9 0 4 1 2 0 0.326 0.815 1.000 40 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(8), GOT1(2), TAT(5), TYR(12) 2741084 27 23 27 4 12 1 9 1 4 0 0.0860 0.819 1.000 41 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(3), CD4(3), HLA-DRA(4), HLA-DRB1(1) 1383675 11 11 11 3 5 1 3 2 0 0 0.401 0.843 1.000 42 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(3), LIPT1(1) 897135 4 4 4 0 3 0 1 0 0 0 0.434 0.860 1.000 43 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF4E(2), EIF4EBP1(1), GSK3B(4), IGF1(2), IGF1R(11), INPPL1(11), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(6), PPP2CA(2), PTEN(16), RPS6(5), RPS6KB1(4) 11452183 188 142 128 26 117 4 26 18 22 1 6.54e-05 0.864 1.000 44 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(12), SPCS3(1) 1788894 15 15 15 4 7 1 4 1 2 0 0.394 0.872 1.000 45 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(3), UGDH(5), UGP2(9), UXS1(3) 2849723 21 19 19 3 8 3 2 3 5 0 0.207 0.881 1.000 46 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(3), GNB1(7), HTR2C(1), PLCB1(16), TUB(4) 4164702 33 30 32 4 18 2 9 3 1 0 0.0266 0.882 1.000 47 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), BCAR1(6), CDKN1B(6), GRB2(1), ILK(3), ITGB1(3), MAPK3(8), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(6), PTEN(16), PTK2(12), SHC1(8), SOS1(23) 11221555 193 149 132 26 122 7 21 22 21 0 0.000438 0.916 1.000 48 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(4), BIRC3(3), CASP8(14), FADD(7), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5) 4817772 57 49 55 9 36 1 7 4 9 0 0.0280 0.929 1.000 49 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(6), AKT1(3), BAD(2), BAX(1), BCL2L1(4), CSF2RB(5), IGF1(2), IGF1R(11), IL3RA(6), KIT(9), KITLG(5), PIK3CA(94), PIK3R1(6), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), YWHAH(2) 12778665 176 136 116 29 94 8 27 23 24 0 0.000128 0.942 1.000 50 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(6), IDI1(2), SQLE(4) 1843674 12 12 12 2 6 0 3 2 1 0 0.313 0.963 1.000 51 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(2) 664914 4 3 4 3 1 0 2 0 1 0 0.943 0.972 1.000 52 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(8), PDXK(4), PDXP(2), PNPO(2), PSAT1(6) 2831492 22 19 22 9 6 1 2 3 10 0 0.855 0.977 1.000 53 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(4), CCNA2(3), CCND1(4), CCNE1(3), CCNE2(7), CDK2(1), CDK4(5), CDKN1B(6), CDKN2A(30), E2F1(3), E2F2(4), E2F4(2), PRB1(2) 5142241 74 58 65 12 30 5 13 2 24 0 0.0652 0.983 1.000 54 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(5), AOC3(6), CES1(4), ESD(3) 3501402 18 18 18 3 7 0 5 4 2 0 0.191 0.984 1.000 55 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(5) 1526099 7 7 7 2 4 0 0 1 2 0 0.615 0.986 1.000 56 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(5), CCL2(1), CSF1(4), IL6(4), LDLR(10), LPL(4) 3116487 28 28 28 6 14 0 4 2 8 0 0.252 0.987 1.000 57 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(1), CCR3(3), HLA-DRA(4), HLA-DRB1(1), IL5(1) 1774605 10 10 10 4 3 0 4 2 1 0 0.723 0.995 1.000 58 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(3), UGDH(5), UXS1(3) 2231739 12 11 12 3 3 2 2 3 2 0 0.577 0.996 1.000 59 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(7), CYP11A1(1), CYP11B2(13), CYP17A1(3), HSD11B2(3), HSD3B1(5), HSD3B2(5) 4025170 37 32 37 8 19 1 13 4 0 0 0.0452 0.997 1.000 60 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(3), CD4(3), CD80(2), HLA-DRA(4), HLA-DRB1(1), IL10(1), IL2(1) 2318348 15 15 15 4 8 1 4 2 0 0 0.333 0.997 1.000 61 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(3), GSTZ1(2), HGD(4) 1306225 9 9 9 4 5 0 0 2 2 0 0.814 0.998 1.000 62 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(5), CYP11A1(1), CYP11B1(4), CYP11B2(13), CYP17A1(3), CYP21A2(2), HSD11B2(3), HSD3B1(5), HSD3B2(5) 5333840 46 39 46 9 23 3 15 5 0 0 0.0280 0.999 1.000 63 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(5), CYP11A1(1), CYP11B1(4), CYP11B2(13), CYP17A1(3), CYP21A2(2), HSD11B2(3), HSD3B1(5), HSD3B2(5) 5333840 46 39 46 9 23 3 15 5 0 0 0.0280 0.999 1.000 64 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(65), ATR(32), BRCA1(23), BRCA2(47), CHEK1(3), CHEK2(11), FANCA(18), FANCC(9), FANCD2(19), FANCE(3), FANCF(4), FANCG(5), HUS1(1), MRE11A(7), RAD1(3), RAD17(6), RAD50(13), RAD51(7), RAD9A(2), TP53(226), TREX1(8) 25798997 512 268 397 52 206 21 119 49 112 5 7.79e-10 0.999 1.000 65 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), CDC42(4), RAC1(4), WASF1(5), WASL(2) 4739468 39 35 39 6 19 3 5 4 8 0 0.129 0.999 1.000 66 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(3), AKT1(3), ANXA1(5), CALM1(2), CALM2(2), GNAS(12), GNB1(7), NFKB1(3), NOS3(11), NPPA(2), NR3C1(6), PIK3CA(94), PIK3R1(6), RELA(6), SYT1(6) 10354522 168 135 107 27 118 8 15 17 10 0 0.00430 0.999 1.000 67 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(2) 1229445 5 5 5 3 1 1 2 1 0 0 0.889 0.999 1.000 68 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(1), IFNGR2(6), JAK1(9), JAK2(8), STAT1(13) 4799687 39 35 38 7 17 1 7 3 11 0 0.182 1.000 1.000 69 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(2), SNAP25(4), STX1A(1), VAMP2(1) 1901498 10 10 10 4 5 1 2 1 1 0 0.634 1.000 1.000 70 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(17), EGFR(7), ERBB3(48), NRG1(14), UBE2D1(2) 6010906 88 75 77 16 40 7 23 10 8 0 0.0532 1.000 1.000 71 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(7), ITGB1(3), KLRC2(2), KLRC3(4), KLRC4(3), KLRD1(1), LAT(1), MAP2K1(3), MAPK3(8), PAK1(4), PIK3CA(94), PIK3R1(6), PTK2B(6), PTPN6(2), RAC1(4), SYK(8), VAV1(8) 10835754 167 135 107 28 102 5 19 22 19 0 0.00306 1.000 1.000 72 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(6), CPS1(13), GLS(3), GLUD1(6), GOT1(2) 4538906 32 26 30 6 17 1 5 4 5 0 0.166 1.000 1.000 73 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(9), CDKN1A(38), EPO(2), EPOR(5), GRIN1(7), HIF1A(6), JAK2(8), NFKB1(3), NFKBIA(6), RELA(6), SOD2(1) 7299863 91 79 82 15 39 3 8 3 33 5 0.250 1.000 1.000 74 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(5), ACAT2(1), HMGCL(1), OXCT1(4) 1983004 11 10 11 7 7 1 0 1 2 0 0.975 1.000 1.000 75 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(6), LPO(8), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), TPO(16), TYR(12) 5592311 63 50 62 13 30 3 19 4 7 0 0.0349 1.000 1.000 76 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(3), GLS2(4), GLUD1(6), GLUD2(10) 2657960 23 21 22 6 10 1 7 1 4 0 0.518 1.000 1.000 77 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(3), FUT2(6), FUT3(3), FUT5(5), FUT6(2), ST3GAL3(3) 2957408 22 21 21 6 13 0 7 0 2 0 0.230 1.000 1.000 78 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(1), HRAS(16), PTK2B(6), SHC1(8), SOS1(23), SRC(5) 5118084 59 51 52 11 27 1 20 7 4 0 0.0914 1.000 1.000 79 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BAD(2), BCL2L1(4), CASP9(6), CDC42(4), CHUK(7), ELK1(1), H2AFX(3), HRAS(16), MAP2K1(3), MAPK3(8), NFKB1(3), PIK3CA(94), PIK3R1(6), RAC1(4), RAF1(4), RALA(2), RALBP1(2), RALGDS(4), RELA(6), RHOA(19) 11021344 201 148 131 32 119 8 32 24 18 0 0.000529 1.000 1.000 80 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDPS(6), HMGCR(7), IDI1(2), LSS(7), MVD(4), NQO2(3), PMVK(1), SQLE(4), VKORC1(1) 6362305 38 33 38 6 21 2 6 5 4 0 0.0390 1.000 1.000 81 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(4), DHCR7(3), FDPS(6), HMGCR(7), HMGCS1(9), IDI1(2), LSS(7), MVD(4), NSDHL(3), PMVK(1), SQLE(4) 7606406 50 44 50 8 28 2 8 8 4 0 0.0289 1.000 1.000 82 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB1A(1), RAB27A(1), RAB3A(2), RAB5A(2), RAB6A(5), RAB9A(1) 2475444 17 15 17 6 7 2 2 3 3 0 0.791 1.000 1.000 83 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(5), BLVRB(1), HMOX1(3), IL10(1), IL10RA(9), IL10RB(8), IL1A(1), IL6(4), JAK1(9), STAT1(13), STAT3(6), STAT5A(1), TNF(4) 7122262 65 55 64 13 31 0 11 3 20 0 0.0220 1.000 1.000 84 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(2), FARSB(6), GOT1(2), PAH(11), TAT(5), YARS(5), YARS2(8) 5069669 40 37 40 9 17 2 5 7 9 0 0.201 1.000 1.000 85 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(50), EP300(77), FYN(7), IL2RG(5), IL7(1), IL7R(7), JAK1(9), JAK3(12), LCK(2), NMI(4), PIK3CA(94), PIK3R1(6), PTK2B(6), STAT5A(1), STAT5B(5) 16206499 286 197 220 46 127 11 43 36 67 2 3.83e-05 1.000 1.000 86 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(3), B3GALT5(3), B3GNT5(8), FUT1(3), FUT2(6), FUT3(3), ST3GAL3(3), ST3GAL4(1) 4212211 32 23 32 9 22 0 7 1 2 0 0.265 1.000 1.000 87 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(1), EHHADH(6), HADHA(4), SDS(2) 2817763 15 15 15 8 11 1 0 0 3 0 0.918 1.000 1.000 88 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(50), EP300(77), LPL(4), NCOA1(24), NCOA2(12), PPARG(13), RXRA(25) 10761211 205 148 182 31 77 8 34 20 64 2 0.00302 1.000 1.000 89 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(6), GGPS1(1), IDI1(2), IDI2(4), SQLE(4) 2479141 17 17 17 5 7 0 6 3 1 0 0.587 1.000 1.000 90 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(1), ACADS(6), ACAT1(5), ECHS1(1), HADHA(4) 3151489 19 19 19 8 11 0 3 2 3 0 0.874 1.000 1.000 91 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(6), GBA(4), LPO(8), MPO(4), PRDX6(5), TPO(16) 4842840 43 38 43 10 19 2 14 4 4 0 0.125 1.000 1.000 92 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), HRAS(16), JUN(4), KLK2(1), MAP2K1(3), MAPK3(8), MAPK8(5), NGFR(4), PIK3CA(94), PIK3R1(6), PLCG1(12), RAF1(4), SHC1(8), SOS1(23) 11130377 205 152 137 32 123 7 32 28 15 0 0.000264 1.000 1.000 93 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(5), ALDOB(3), ALDOC(2), TPI1(1) 2282528 11 11 11 9 5 1 3 1 1 0 0.985 1.000 1.000 94 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(7), BAK1(2), BAX(1), BCL2L1(4), BID(2), BIRC2(3), BIRC3(3), CASP2(2), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), FADD(7), FAS(1), FASLG(1), GZMB(2), JUN(4), MAP2K4(4), MAP3K1(10), MAPK10(9), MCL1(2), MDM2(6), MYC(2), NFKB1(3), NFKBIA(6), PARP1(13), PRF1(7), RELA(6), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TNFSF10(5), TP53(226), TRADD(2), TRAF2(5) 21671424 397 249 284 62 157 11 107 29 91 2 2.25e-06 1.000 1.000 95 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(4), FOSL1(3), FOSL2(5), IFNAR1(2), IFNAR2(5), IFNB1(1), MAPK8(5), NFKB1(3), RELA(6), TNFRSF11A(1), TNFSF11(1), TRAF6(1) 6421901 37 33 36 9 18 1 5 1 11 1 0.582 1.000 1.000 96 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(1), DAG1(3), GNAQ(3), ITPKA(4), ITPKB(5) 3476319 20 20 20 6 10 1 5 4 0 0 0.479 1.000 1.000 97 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(14), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(2), APOBEC3C(3), APOBEC3F(1), APOBEC4(7) 4289239 33 29 33 9 23 2 6 2 0 0 0.359 1.000 1.000 98 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(4), ACAA2(2), ACAT1(5), ACAT2(1), ECHS1(1), EHHADH(6), HADHA(4), HADHB(4), SDS(2) 4887057 29 25 28 9 19 2 0 1 7 0 0.674 1.000 1.000 99 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(3), CD4(3), HLA-DRA(4), HLA-DRB1(1), IL1B(3), IL5(1), IL5RA(4), IL6(4) 3126878 23 20 23 9 11 1 5 4 2 0 0.680 1.000 1.000 100 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(12), GABRA2(6), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), PRKCE(5), SOD1(4) 4593551 59 52 59 15 14 3 20 14 8 0 0.294 1.000 1.000 101 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(11), GABARAP(3), GABRA1(12), GABRA2(6), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GPHN(5), NSF(6), SRC(5), UBQLN1(5) 6922805 85 68 84 19 28 4 24 18 11 0 0.143 1.000 1.000 102 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(2), GLS(3), GLUD1(6), OAT(1), PRODH(3) 3204178 19 18 18 7 12 2 3 0 2 0 0.775 1.000 1.000 103 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(2), CAT(9), EPX(6), LPO(8), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), SHMT1(3), SHMT2(2), TPO(16) 6839783 68 55 67 16 35 2 17 6 8 0 0.0561 1.000 1.000 104 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(6), LARS(11), LARS2(3), PDHA1(5), PDHA2(6), PDHB(1) 5836285 36 31 36 7 19 1 6 3 7 0 0.312 1.000 1.000 105 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP1(2), RANBP2(28), RANGAP1(4) 4925357 35 32 35 8 19 4 5 2 5 0 0.710 1.000 1.000 106 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL15(1), IL16(13), IL1A(1), IL2(1), IL5(1), IL6(4), LTA(1), TNF(4) 5783775 35 31 35 9 22 0 7 2 4 0 0.222 1.000 1.000 107 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAPK14(2), MAPK3(8), NFKB1(3), PIK3CA(94), PIK3R1(6), RB1(73), RELA(6), SP1(10) 11271904 230 175 164 36 105 7 18 21 73 6 0.00349 1.000 1.000 108 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), GRB2(1), HRAS(16), MAPK3(8), MAPK7(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), NTRK1(6), PIK3CA(94), PIK3R1(6), PLCG1(12), RPS6KA1(5), SHC1(8) 10984337 180 142 115 34 108 7 36 17 12 0 0.000994 1.000 1.000 109 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), GRB2(1), HRAS(16), KLK2(1), NTRK1(6), PIK3CA(94), PIK3R1(6), PLCG1(12), PRKCA(3), SHC1(8), SOS1(23) 9107325 173 143 107 31 108 4 31 22 8 0 0.00333 1.000 1.000 110 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(5), GOT1(2), LDHB(2), LDHC(4), MPST(1) 3992401 18 18 18 8 10 2 3 1 2 0 0.859 1.000 1.000 111 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(9), LDLR(10), MBTPS1(13), MBTPS2(7), SCAP(9), SREBF1(6), SREBF2(8) 6841875 62 55 61 16 29 1 14 4 14 0 0.136 1.000 1.000 112 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), P2RY1(3), P2RY2(1), P2RY6(2) 3479393 16 14 16 9 4 1 4 6 1 0 0.759 1.000 1.000 113 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(11), CD44(2), CSF1(4), FCGR3A(6), IL1B(3), IL6R(4), SPN(6), TGFB1(2), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TNFRSF8(8), TNFSF8(4) 7576664 65 47 62 14 31 0 21 4 9 0 0.0519 1.000 1.000 114 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), HRAS(16), IGF1(2), IGF1R(11), IRS1(9), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PIK3CA(94), PIK3R1(6), PTPN11(4), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4) 14437897 226 172 158 36 132 6 39 32 17 0 0.000262 1.000 1.000 115 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(3) 8771309 76 63 75 17 37 6 12 10 11 0 0.0689 1.000 1.000 116 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(3) 8771309 76 63 75 17 37 6 12 10 11 0 0.0689 1.000 1.000 117 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(3) 8771309 76 63 75 17 37 6 12 10 11 0 0.0689 1.000 1.000 118 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(9), EPX(6), LPO(8), MPO(4), MTHFR(4), PRDX6(5), SHMT1(3), SHMT2(2), TPO(16) 6743191 58 49 58 15 27 3 17 5 6 0 0.140 1.000 1.000 119 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), DDC(8), EPX(6), GOT1(2), HPD(4), LPO(8), MAOA(4), MAOB(2), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), TAT(5), TPO(16) 12703476 104 78 103 23 50 3 26 9 16 0 0.00744 1.000 1.000 120 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(7), CREBBP(50), EP300(77), FADD(7), HDAC3(1), IKBKB(11), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF6(1) 12947961 193 138 184 33 76 6 28 18 63 2 0.00450 1.000 1.000 121 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(3), PSMA5(5), PSMA6(6), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC3(5), RPN1(3), RPN2(5), UBE2A(2), UBE3A(10) 7496769 58 52 57 12 36 1 9 7 5 0 0.152 1.000 1.000 122 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7) 7687900 48 43 48 12 21 2 11 4 10 0 0.197 1.000 1.000 123 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(12), EIF2AK4(11), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF5(9), GSK3B(4), PPP1CA(8) 6762412 67 51 67 13 35 1 15 6 10 0 0.189 1.000 1.000 124 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(1), JAK1(9), JAK2(8), PLA2G2A(2), PTPRU(7), REG1A(8), STAT1(13) 6688362 51 46 50 12 23 0 15 4 9 0 0.228 1.000 1.000 125 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(6), CREBBP(50), EP300(77), NCOA3(16), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RARA(4), RXRA(25) 12026063 198 142 177 35 66 10 34 21 65 2 0.00990 1.000 1.000 126 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), BAD(2), GRB2(1), HRAS(16), IGF1R(11), IRS1(9), MAP2K1(3), MAPK3(8), PIK3CA(94), PIK3R1(6), RAF1(4), SHC1(8), SOS1(23), YWHAH(2) 11104597 190 151 124 34 112 6 32 27 13 0 0.00342 1.000 1.000 127 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(3), IARS(6), IARS2(10), ILVBL(3), LARS(11), LARS2(3), PDHA1(5), PDHA2(6), PDHB(1), VARS(5), VARS2(12) 10782385 69 58 69 12 36 3 18 3 9 0 0.0465 1.000 1.000 128 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(29), CDH1(15), CREBBP(50), EP300(77), MAP2K1(3), MAP3K7(8), MAPK3(8), SKIL(15), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8) 14971808 223 149 215 31 78 8 32 22 79 4 0.00182 1.000 1.000 129 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), FDXR(5), SHMT1(3) 9323680 81 67 80 20 42 6 12 10 11 0 0.100 1.000 1.000 130 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(6), CRK(4), CXCR4(4), GNAI1(4), GNAQ(3), GNB1(7), HRAS(16), MAP2K1(3), MAPK3(8), NFKB1(3), PIK3C2G(11), PIK3CA(94), PIK3R1(6), PLCG1(12), PRKCA(3), PTK2(12), PTK2B(6), PXN(3), RAF1(4), RELA(6) 15949164 215 153 149 37 128 12 34 26 15 0 0.000258 1.000 1.000 131 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(4), IL6R(4), JAK1(9), JAK2(8), JAK3(12), PIAS3(5), PTPRU(7), REG1A(8), SRC(5), STAT3(6) 8831183 69 58 69 18 32 2 21 4 10 0 0.172 1.000 1.000 132 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(6), ADRB2(3), CFTR(18), GNAS(12), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 7603732 59 47 59 14 26 3 14 10 6 0 0.210 1.000 1.000 133 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(2), ACVR1C(3), AKT1(3), AKT2(4), AKT3(6), ARRB1(4), ARRB2(4), ATF2(1), ATF4(3), BDNF(3), BRAF(9), CACNA1A(25), CACNA1B(17), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1F(11), CACNA1G(16), CACNA1H(12), CACNA1I(8), CACNA1S(12), CACNA2D1(19), CACNA2D2(6), CACNA2D3(8), CACNA2D4(8), CACNB1(5), CACNB2(8), CACNB3(5), CACNB4(3), CACNG1(1), CACNG2(3), CACNG3(4), CACNG4(8), CACNG5(7), CACNG6(3), CACNG7(8), CACNG8(3), CASP3(3), CD14(3), CDC25B(2), CDC42(4), CHUK(7), CRK(4), CRKL(1), DAXX(9), DDIT3(1), DUSP1(3), DUSP10(4), DUSP14(4), DUSP16(6), DUSP2(2), DUSP4(2), DUSP5(1), DUSP6(7), DUSP7(4), DUSP8(6), DUSP9(3), ECSIT(4), EGF(17), EGFR(7), ELK1(1), ELK4(6), FAS(1), FASLG(1), FGF1(2), FGF10(4), FGF11(1), FGF12(5), FGF13(5), FGF14(6), FGF16(2), FGF17(1), FGF19(2), FGF23(3), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(1), FGF8(3), FGF9(4), FGFR1(6), FGFR2(10), FGFR3(64), FGFR4(6), FLNA(14), FLNB(23), FLNC(18), FOS(4), GADD45A(1), GADD45G(1), GNA12(3), GNG12(2), GRB2(1), HRAS(16), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), JUN(4), JUND(2), KRAS(13), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K5(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K6(9), MAP3K7(8), MAP3K8(5), MAP4K1(8), MAP4K2(5), MAP4K3(12), MAP4K4(7), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK7(3), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MAPKAPK2(1), MAPKAPK3(3), MAPKAPK5(3), MAPT(10), MEF2C(5), MKNK1(6), MKNK2(3), MOS(2), MRAS(2), MYC(2), NF1(38), NFATC2(13), NFATC4(5), NFKB1(3), NFKB2(3), NLK(6), NR4A1(2), NRAS(7), NTF3(1), NTRK1(6), NTRK2(7), PAK1(4), PAK2(9), PDGFB(2), PDGFRA(16), PDGFRB(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PPM1A(6), PPM1B(7), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PPP5C(7), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKX(1), PTPN5(2), PTPN7(1), PTPRR(7), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF2(16), RASA1(8), RASA2(6), RASGRF1(12), RASGRF2(9), RASGRP1(6), RASGRP2(4), RASGRP3(5), RASGRP4(1), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA4(3), RPS6KA5(9), RPS6KA6(11), RRAS(2), RRAS2(1), SOS1(23), SOS2(8), SRF(4), STK3(7), STK4(6), TAOK1(11), TAOK2(13), TAOK3(15), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8), TNF(4), TNFRSF1A(5), TP53(226), TRAF2(5), TRAF6(1), ZAK(10) 164604592 1619 367 1437 513 716 56 399 174 267 7 0.413 1.000 1.000 134 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), AKT1(3), AKT2(4), AKT3(6), ARHGAP5(12), BAD(2), BCAR1(6), BIRC2(3), BIRC3(3), BRAF(9), CAPN2(2), CAV2(1), CAV3(1), CCND1(4), CCND2(1), CCND3(5), CDC42(4), CHAD(3), COL11A1(29), COL11A2(13), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(6), COL6A3(27), COL6A6(28), COMP(8), CRK(4), CRKL(1), CTNNB1(15), DIAPH1(5), DOCK1(11), EGF(17), EGFR(7), ELK1(1), ERBB2(54), FARP2(7), FIGF(2), FLNA(14), FLNB(23), FLNC(18), FLT1(8), FN1(20), FYN(7), GRB2(1), GSK3B(4), HGF(12), HRAS(16), IBSP(4), IGF1(2), IGF1R(11), ILK(3), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAV(13), ITGB1(3), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), JUN(4), KDR(19), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(22), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), MAP2K1(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MET(19), MYL2(4), MYL5(2), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PARVB(6), PARVG(3), PDGFB(2), PDGFC(5), PDGFD(8), PDGFRA(16), PDGFRB(7), PDPK1(2), PGF(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP5K1C(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PRKCA(3), PRKCG(6), PTEN(16), PTK2(12), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF1(6), RELN(36), RHOA(19), ROCK1(8), ROCK2(15), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SPP1(2), SRC(5), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TLN1(17), TLN2(13), TNC(19), TNN(20), TNR(12), TNXB(38), VASP(1), VAV1(8), VAV2(8), VAV3(7), VCL(4), VEGFA(4), VEGFB(3), VEGFC(6), VTN(3), VWF(21), ZYX(4) 214658828 1849 363 1722 566 905 83 429 199 233 0 0.613 1.000 1.000 135 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(7), ACTN1(7), ACTN2(10), ACTN4(13), APC(29), APC2(6), ARAF(2), ARHGEF1(8), ARHGEF12(14), ARHGEF4(3), ARHGEF6(7), ARHGEF7(9), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), ARPC5(5), BAIAP2(5), BCAR1(6), BDKRB1(4), BDKRB2(2), BRAF(9), CD14(3), CDC42(4), CFL1(1), CFL2(4), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CRK(4), CRKL(1), CSK(7), CYFIP1(7), CYFIP2(9), DIAPH1(5), DIAPH2(21), DIAPH3(7), DOCK1(11), EGF(17), EGFR(7), EZR(12), F2(3), F2R(2), FGD1(6), FGD3(4), FGF1(2), FGF10(4), FGF11(1), FGF12(5), FGF13(5), FGF14(6), FGF16(2), FGF17(1), FGF19(2), FGF23(3), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(1), FGF8(3), FGF9(4), FGFR1(6), FGFR2(10), FGFR3(64), FGFR4(6), FN1(20), GIT1(6), GNA12(3), GNA13(12), GNG12(2), GSN(2), HRAS(16), IQGAP1(11), IQGAP2(10), IQGAP3(12), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAD(4), ITGAE(11), ITGAL(17), ITGAM(13), ITGAV(13), ITGAX(3), ITGB1(3), ITGB2(7), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), KRAS(13), LIMK1(6), LIMK2(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MOS(2), MRAS(2), MSN(1), MYH10(24), MYH14(7), MYH9(35), MYL2(4), MYL5(2), MYLK(15), MYLK2(7), NCKAP1(12), NCKAP1L(10), NRAS(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PDGFB(2), PDGFRA(16), PDGFRB(7), PFN1(4), PFN2(1), PFN3(1), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PPP1R12B(10), PTK2(12), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RDX(4), RHOA(19), ROCK1(8), ROCK2(15), RRAS(2), RRAS2(1), SCIN(1), SLC9A1(7), SOS1(23), SOS2(8), SSH1(7), SSH2(18), SSH3(17), TIAM1(17), TIAM2(18), VAV1(8), VAV2(8), VAV3(7), VCL(4), WAS(4), WASF1(5), WASF2(7), WASL(2) 159672928 1469 358 1322 427 770 57 291 173 177 1 0.0715 1.000 1.000 136 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY7(4), ADCY8(18), ADCY9(8), ADORA2A(1), ADORA2B(1), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRB1(3), ADRB2(3), AGTR1(3), ATP2A1(9), ATP2A2(10), ATP2A3(5), ATP2B1(11), ATP2B2(13), ATP2B3(3), ATP2B4(15), AVPR1A(4), AVPR1B(3), BDKRB1(4), BDKRB2(2), BST1(3), CACNA1A(25), CACNA1B(17), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1F(11), CACNA1G(16), CACNA1H(12), CACNA1I(8), CACNA1S(12), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CCKAR(3), CCKBR(8), CD38(1), CHRM1(2), CHRM2(5), CHRM3(8), CHRM5(3), CHRNA7(2), CYSLTR2(2), DRD1(2), EDNRA(4), EDNRB(8), EGFR(7), ERBB2(54), ERBB3(48), ERBB4(11), F2R(2), GNA11(3), GNA14(3), GNA15(5), GNAL(4), GNAQ(3), GNAS(12), GRIN1(7), GRIN2A(14), GRIN2C(10), GRIN2D(9), GRM1(22), GRM5(18), GRPR(1), HRH1(9), HRH2(1), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), LHCGR(7), LTB4R2(3), MYLK(15), MYLK2(7), NOS1(15), NOS3(11), NTSR1(2), OXTR(1), P2RX1(3), P2RX2(8), P2RX3(4), P2RX5(2), P2RX7(5), PDE1A(8), PDE1B(4), PDE1C(15), PDGFRA(16), PDGFRB(7), PHKA1(14), PHKA2(8), PHKB(10), PHKG1(3), PHKG2(3), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLCD1(5), PLCD3(6), PLCD4(5), PLCE1(10), PLCG1(12), PLCG2(6), PLCZ1(5), PLN(2), PPID(2), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKX(1), PTAFR(1), PTGER3(2), PTGFR(7), PTK2B(6), RYR1(54), RYR2(83), RYR3(53), SLC25A4(2), SLC25A6(1), SLC8A1(8), SLC8A2(11), SLC8A3(5), SPHK1(1), SPHK2(10), TACR1(3), TACR2(1), TACR3(5), TNNC1(2), TNNC2(1), TRHR(9), TRPC1(9), VDAC1(3), VDAC2(3) 155176749 1324 338 1269 583 616 69 347 132 158 2 1.000 1.000 1.000 137 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(9), ANAPC1(17), ANAPC2(12), ANAPC4(8), ANAPC5(12), ANAPC7(6), ATM(65), ATR(32), BUB1(18), BUB1B(11), BUB3(3), CCNA1(4), CCNA2(3), CCNB1(5), CCNB3(9), CCND1(4), CCND2(1), CCND3(5), CCNE1(3), CCNE2(7), CCNH(4), CDC14A(5), CDC14B(10), CDC16(4), CDC20(4), CDC23(1), CDC25A(5), CDC25B(2), CDC25C(2), CDC27(12), CDC6(9), CDC7(4), CDK2(1), CDK4(5), CDK6(5), CDK7(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(2), CDKN2C(2), CDKN2D(1), CHEK1(3), CHEK2(11), CREBBP(50), CUL1(19), DBF4(11), E2F1(3), E2F2(4), E2F3(5), EP300(77), ESPL1(17), FZR1(5), GADD45A(1), GADD45G(1), GSK3B(4), HDAC1(4), HDAC2(3), MAD1L1(3), MAD2L1(3), MAD2L2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), PCNA(4), PKMYT1(2), PLK1(5), PRKDC(35), PTTG1(2), RB1(73), RBL1(9), RBL2(9), RBX1(1), SFN(1), SKP1(6), SKP2(5), SMAD2(4), SMAD3(6), SMAD4(8), SMC1A(16), SMC1B(8), TFDP1(2), TGFB1(2), TGFB3(1), TP53(226), WEE1(10), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 78745666 1114 338 959 177 438 38 195 102 321 20 5.76e-10 1.000 1.000 138 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(29), APC2(6), AXIN1(4), AXIN2(19), BTRC(4), CACYBP(1), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CCND1(4), CCND2(1), CCND3(5), CER1(4), CHD8(18), CREBBP(50), CSNK1A1(6), CSNK1A1L(4), CSNK1E(3), CSNK2A1(11), CSNK2B(5), CTBP1(4), CTBP2(7), CTNNB1(15), CTNNBIP1(1), CUL1(19), CXXC4(1), DAAM1(10), DAAM2(9), DKK1(2), DKK2(5), DKK4(2), DVL1(5), DVL2(9), DVL3(4), EP300(77), FBXW11(1), FOSL1(3), FZD1(4), FZD10(9), FZD2(3), FZD3(6), FZD4(2), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GSK3B(4), JUN(4), LEF1(4), LRP5(8), LRP6(15), MAP3K7(8), MAPK10(9), MAPK8(5), MAPK9(5), MMP7(1), MYC(2), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NKD1(3), NKD2(1), NLK(6), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PORCN(2), PPARD(6), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(3), PPP2R2C(4), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRICKLE1(7), PRICKLE2(7), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKX(1), PSEN1(8), RAC1(4), RAC2(1), RAC3(3), RBX1(1), RHOA(19), ROCK1(8), ROCK2(15), RUVBL1(6), SENP2(1), SFRP1(2), SFRP2(4), SFRP4(5), SIAH1(2), SKP1(6), SMAD2(4), SMAD3(6), SMAD4(8), SOX17(3), TBL1X(5), TBL1XR1(8), TBL1Y(3), TCF7(1), TCF7L2(1), TP53(226), VANGL1(5), VANGL2(3), WIF1(6), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(3), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2) 93550978 1075 332 940 286 464 45 243 103 216 4 0.0396 1.000 1.000 139 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), AKT1(3), AKT2(4), AKT3(6), AMOTL1(8), ASH1L(35), CASK(9), CDC42(4), CDK4(5), CGN(10), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CSNK2A1(11), CSNK2B(5), CTNNA1(6), CTNNA2(21), CTNNA3(11), CTNNB1(15), CTTN(9), EPB41(9), EPB41L1(8), EPB41L2(8), EPB41L3(17), EXOC3(8), EXOC4(13), F11R(5), GNAI1(4), GNAI2(5), GNAI3(6), HCLS1(5), HRAS(16), IGSF5(4), INADL(16), JAM2(1), JAM3(4), KRAS(13), LLGL1(4), LLGL2(5), MAGI1(15), MAGI2(17), MAGI3(16), MLLT4(15), MPDZ(20), MPP5(5), MRAS(2), MYH1(16), MYH10(24), MYH11(22), MYH13(21), MYH14(7), MYH15(22), MYH2(22), MYH3(19), MYH4(21), MYH6(14), MYH7(19), MYH7B(16), MYH8(17), MYH9(35), MYL2(4), MYL5(2), NRAS(7), OCLN(4), PARD3(22), PARD6A(7), PARD6B(5), PARD6G(1), PPM1J(3), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(3), PPP2R2C(4), PPP2R3A(13), PPP2R3B(4), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PTEN(16), RAB13(2), RAB3B(5), RHOA(19), RRAS(2), RRAS2(1), SPTAN1(68), SRC(5), SYMPK(11), TJAP1(2), TJP1(9), TJP2(13), TJP3(4), VAPA(6), YES1(6), ZAK(10) 112809305 1103 325 1067 322 550 59 220 91 181 2 0.260 1.000 1.000 140 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(7), ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), ADRA1A(5), ADRA1B(1), ADRA2A(3), ADRA2B(1), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(4), AVPR1B(3), AVPR2(3), BDKRB1(4), BDKRB2(2), BRS3(4), C3AR1(4), C5AR1(3), CALCR(9), CALCRL(8), CCKAR(3), CCKBR(8), CGA(2), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CNR1(4), CNR2(6), CRHR1(2), CRHR2(3), CTSG(4), CYSLTR2(2), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), EDNRA(4), EDNRB(8), F2(3), F2R(2), F2RL1(5), F2RL2(2), F2RL3(2), FPR1(3), FSHB(1), FSHR(5), GABBR1(6), GABBR2(6), GABRA1(12), GABRA2(6), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GABRB1(7), GABRB2(7), GABRB3(9), GABRD(3), GABRE(6), GABRG1(9), GABRG2(5), GABRG3(4), GABRP(3), GABRQ(6), GABRR1(6), GABRR2(2), GALR1(3), GALR2(4), GALR3(3), GH1(3), GH2(3), GHR(6), GHRHR(3), GHSR(6), GIPR(3), GLP1R(3), GLP2R(2), GLRA1(6), GLRA2(4), GLRA3(5), GLRB(3), GNRHR(2), GPR156(7), GPR35(2), GPR50(15), GPR63(3), GPR83(3), GRIA1(16), GRIA2(7), GRIA3(6), GRIA4(21), GRID1(12), GRID2(12), GRIK1(12), GRIK2(15), GRIK3(15), GRIK4(7), GRIK5(14), GRIN1(7), GRIN2A(14), GRIN2B(10), GRIN2C(10), GRIN2D(9), GRIN3A(5), GRIN3B(2), GRM1(22), GRM2(10), GRM3(8), GRM4(9), GRM5(18), GRM6(9), GRM7(12), GRM8(8), GRPR(1), GZMA(4), HCRTR1(1), HCRTR2(10), HRH1(9), HRH2(1), HRH3(4), HRH4(3), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), LEP(1), LEPR(8), LHB(2), LHCGR(7), LTB4R2(3), MAS1(2), MC1R(2), MC3R(4), MC4R(3), MC5R(3), MCHR1(3), MCHR2(3), MLNR(3), MTNR1A(4), MTNR1B(1), NMBR(6), NMUR2(1), NPBWR2(4), NPFFR1(2), NPFFR2(6), NPY1R(7), NPY2R(4), NPY5R(5), NR3C1(6), NTSR1(2), NTSR2(2), OPRD1(5), OPRK1(4), OPRL1(2), OXTR(1), P2RX1(3), P2RX2(8), P2RX3(4), P2RX5(2), P2RX7(5), P2RY1(3), P2RY10(2), P2RY11(1), P2RY13(3), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(2), P2RY8(1), PARD3(22), PRL(3), PRLHR(4), PRLR(4), PRSS1(2), PTAFR(1), PTGDR(3), PTGER2(7), PTGER3(2), PTGER4(5), PTGFR(7), PTGIR(2), PTH2R(8), RXFP1(8), RXFP2(4), SCTR(4), SSTR1(3), SSTR3(4), SSTR4(6), SSTR5(1), TAAR1(3), TAAR5(2), TAAR6(3), TAAR8(4), TACR1(3), TACR2(1), TACR3(5), THRA(2), THRB(1), TRHR(9), TRPV1(3), TSHR(8), UTS2R(1), VIPR1(1), VIPR2(4) 128714603 1077 321 1066 507 435 51 316 142 132 1 0.998 1.000 1.000 141 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(9), ATM(65), BUB1(18), BUB1B(11), BUB3(3), CCNA1(4), CCNA2(3), CCNB1(5), CCNB3(9), CCND2(1), CCND3(5), CCNE1(3), CCNE2(7), CCNH(4), CDAN1(6), CDC14A(5), CDC14B(10), CDC20(4), CDC25A(5), CDC25B(2), CDC25C(2), CDC6(9), CDC7(4), CDH1(15), CDK2(1), CDK4(5), CDKN1A(38), CDKN2A(30), CHEK1(3), CHEK2(11), DTX4(3), E2F1(3), E2F2(4), E2F3(5), E2F4(2), E2F5(3), E2F6(2), EP300(77), ESPL1(17), GADD45A(1), GSK3B(4), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(6), HDAC6(12), HDAC8(4), MAD1L1(3), MAD2L1(3), MAD2L2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), MPEG1(12), MPL(7), PCNA(4), PLK1(5), PRKDC(35), PTPRA(2), PTTG1(2), RB1(73), RBL1(9), SKP2(5), SMAD4(8), TBC1D8(7), TFDP1(2), TGFB1(2), TP53(226), WEE1(10) 63548681 908 320 767 153 340 30 155 83 284 16 1.93e-08 1.000 1.000 142 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(20), ACTG1(11), CHAD(3), COL11A1(29), COL11A2(13), COL17A1(8), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(6), COL6A3(27), COL6A6(28), COMP(8), DES(2), DSC1(9), DSC2(4), DSC3(10), DSG1(12), DSG2(11), DSG3(7), DSG4(9), FN1(20), GJA1(3), GJA10(4), GJA3(3), GJA4(2), GJA5(5), GJA8(4), GJA9(6), GJB2(2), GJB3(3), GJB5(4), GJB6(2), GJB7(1), GJC1(1), GJC3(1), GJD2(4), GJD4(4), IBSP(4), INA(2), ITGA6(9), ITGB4(15), KRT1(2), KRT10(6), KRT12(4), KRT13(4), KRT14(3), KRT15(5), KRT16(5), KRT17(4), KRT18(5), KRT19(8), KRT2(4), KRT20(7), KRT23(2), KRT24(7), KRT25(2), KRT27(4), KRT28(4), KRT3(4), KRT31(2), KRT32(3), KRT33A(3), KRT33B(9), KRT34(3), KRT35(3), KRT36(5), KRT37(1), KRT38(6), KRT39(5), KRT4(4), KRT40(4), KRT5(7), KRT6A(6), KRT6B(3), KRT6C(6), KRT7(2), KRT71(6), KRT72(3), KRT73(4), KRT74(2), KRT75(6), KRT76(5), KRT77(4), KRT78(5), KRT79(6), KRT8(5), KRT82(3), KRT83(5), KRT84(10), KRT85(3), KRT9(4), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(22), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), LMNA(5), LMNB1(4), LMNB2(7), NES(20), PRPH(4), RELN(36), SPP1(2), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNC(19), TNN(20), TNR(12), TNXB(38), VIM(7), VTN(3), VWF(21) 144100947 1146 319 1124 420 551 51 300 101 142 1 1.000 1.000 1.000 143 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(12), CD36(2), CD44(2), CD47(2), CHAD(3), COL11A1(29), COL11A2(13), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(6), COL6A3(27), COL6A6(28), DAG1(3), FN1(20), FNDC1(17), FNDC3A(12), GP5(1), GP6(3), GP9(3), HMMR(2), HSPG2(33), IBSP(4), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAV(13), ITGB1(3), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(22), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), RELN(36), SDC1(4), SDC2(3), SDC3(2), SDC4(1), SPP1(2), SV2A(6), SV2B(6), SV2C(6), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNC(19), TNN(20), TNR(12), TNXB(38), VTN(3), VWF(21) 129159742 1005 313 992 354 469 46 250 98 142 0 0.998 1.000 1.000 144 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(9), ABLIM1(7), ABLIM2(3), ABLIM3(2), ARHGEF12(14), CDC42(4), CDK5(3), CFL1(1), CFL2(4), CXCR4(4), DCC(26), DPYSL2(4), DPYSL5(1), EFNA1(1), EFNA2(1), EFNA3(1), EFNA4(1), EFNA5(2), EFNB1(3), EFNB2(6), EFNB3(4), EPHA1(4), EPHA2(20), EPHA3(20), EPHA4(2), EPHA5(23), EPHA6(14), EPHA7(12), EPHA8(10), EPHB1(14), EPHB2(10), EPHB3(12), EPHB4(7), EPHB6(11), FES(3), FYN(7), GNAI1(4), GNAI2(5), GNAI3(6), GSK3B(4), HRAS(16), ITGB1(3), KRAS(13), L1CAM(8), LIMK1(6), LIMK2(4), LRRC4C(8), MAPK3(8), MET(19), NCK1(2), NCK2(5), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NGEF(5), NRAS(7), NRP1(8), NTN1(5), NTN4(4), NTNG1(6), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PLXNA1(8), PLXNA2(17), PLXNA3(7), PLXNB1(13), PLXNB2(22), PLXNB3(9), PLXNC1(9), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PTK2(12), RAC1(4), RAC2(1), RAC3(3), RASA1(8), RGS3(3), RHOA(19), RND1(4), ROBO1(17), ROBO2(22), ROBO3(6), ROCK1(8), ROCK2(15), SEMA3A(11), SEMA3C(9), SEMA3D(18), SEMA3E(13), SEMA3F(6), SEMA3G(8), SEMA4A(9), SEMA4B(3), SEMA4C(5), SEMA4D(3), SEMA4F(3), SEMA4G(6), SEMA5A(7), SEMA5B(16), SEMA6A(5), SEMA6B(6), SEMA6C(8), SEMA6D(12), SEMA7A(3), SLIT1(10), SLIT2(17), SLIT3(11), SRGAP1(7), SRGAP2(10), SRGAP3(7), UNC5A(5), UNC5B(10), UNC5C(17), UNC5D(9) 113686802 984 312 959 322 423 46 278 110 125 2 0.602 1.000 1.000 145 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(4), AKT1(3), AKT2(4), AKT3(6), APAF1(7), ATM(65), BAD(2), BAX(1), BCL2L1(4), BID(2), BIRC2(3), BIRC3(3), CAPN1(5), CAPN2(2), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CSF2RB(5), CYCS(1), DFFA(6), FADD(7), FAS(1), FASLG(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1RAP(5), IL3RA(6), IRAK1(3), IRAK2(5), IRAK3(9), IRAK4(7), MYD88(1), NFKB1(3), NFKB2(3), NFKBIA(6), NTRK1(6), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RELA(6), RIPK1(7), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFRSF1A(5), TNFSF10(5), TP53(226), TRADD(2), TRAF2(5) 48377566 701 311 527 134 325 23 144 64 142 3 1.88e-06 1.000 1.000 146 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(65), CCNA1(4), CCNB1(5), CCND1(4), CCND2(1), CCND3(5), CCNE1(3), CCNE2(7), CCNG2(4), CCNH(4), CDC25A(5), CDK2(1), CDK4(5), CDK7(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(2), CDKN2C(2), CDKN2D(1), CREB3L3(7), CREB3L4(7), E2F1(3), E2F2(4), E2F3(5), E2F4(2), E2F5(3), E2F6(2), GADD45A(1), GBA2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), MNAT1(4), MYC(2), MYT1(10), NACA(14), PCNA(4), POLA2(11), POLE(27), POLE2(4), RB1(73), RBL1(9), RPA2(1), RPA3(4), TFDP1(2), TFDP2(5), TNXB(38), TP53(226), WEE1(10) 44759364 719 308 580 115 259 24 148 51 223 14 6.67e-08 1.000 1.000 147 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(9), ABL2(7), AKT1(3), AKT2(4), AKT3(6), ARAF(2), AREG(2), BAD(2), BRAF(9), BTC(1), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CBL(8), CBLB(13), CBLC(3), CDKN1A(38), CDKN1B(6), CRK(4), CRKL(1), EGF(17), EGFR(7), EIF4EBP1(1), ELK1(1), ERBB2(54), ERBB3(48), ERBB4(11), EREG(1), GAB1(6), GRB2(1), GSK3B(4), HBEGF(1), HRAS(16), JUN(4), KRAS(13), MAP2K1(3), MAP2K2(5), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MYC(2), NCK1(2), NCK2(5), NRAS(7), NRG1(14), NRG2(2), NRG3(8), NRG4(1), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PRKCA(3), PRKCG(6), PTK2(12), RAF1(4), RPS6KB1(4), RPS6KB2(1), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SRC(5), STAT5A(1), STAT5B(5) 59691762 685 306 559 180 345 34 145 66 89 6 0.0935 1.000 1.000 148 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(27), ACACB(20), AKT1(3), AKT2(4), AKT3(6), ARAF(2), BAD(2), BRAF(9), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CBL(8), CBLB(13), CBLC(3), CRK(4), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(8), FASN(12), FBP1(3), FBP2(2), FLOT1(3), FLOT2(5), FOXO1(2), G6PC(2), G6PC2(2), GCK(1), GRB2(1), GSK3B(4), GYS1(12), GYS2(13), HRAS(16), IKBKB(11), INPP5D(5), INSR(10), IRS1(9), IRS2(5), IRS4(18), KRAS(13), LIPE(14), MAP2K1(3), MAP2K2(5), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MKNK1(6), MKNK2(3), NRAS(7), PCK1(9), PCK2(2), PDE3A(11), PDE3B(9), PDPK1(2), PFKL(1), PFKM(5), PFKP(4), PHKA1(14), PHKA2(8), PHKB(10), PHKG1(3), PHKG2(3), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PKLR(8), PPARGC1A(18), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R3A(18), PPP1R3B(3), PPP1R3C(4), PPP1R3D(3), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAG1(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCI(8), PRKCZ(4), PRKX(1), PTPN1(5), PTPRF(14), PYGB(8), PYGL(4), PYGM(13), RAF1(4), RAPGEF1(6), RHEB(4), RHOQ(1), RPS6(5), RPS6KB1(4), RPS6KB2(1), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SLC2A4(4), SOCS3(1), SOCS4(1), SORBS1(10), SOS1(23), SOS2(8), SREBF1(6), TRIP10(6), TSC1(34), TSC2(11) 92696070 871 305 786 276 446 28 181 94 121 1 0.522 1.000 1.000 149 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(3), AKT2(4), AKT3(6), BCL2L1(4), CBL(8), CBLB(13), CBLC(3), CCND1(4), CCND2(1), CCND3(5), CISH(1), CLCF1(3), CNTF(5), CNTFR(1), CREBBP(50), CRLF2(2), CSF2RA(7), CSF2RB(5), CSF3(1), CSF3R(4), EP300(77), EPO(2), EPOR(5), GH1(3), GH2(3), GHR(6), GRB2(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(5), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IFNK(4), IFNW1(2), IL10(1), IL10RA(9), IL10RB(8), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL13RA1(2), IL15(1), IL15RA(1), IL19(2), IL2(1), IL20(1), IL20RA(6), IL21(3), IL21R(8), IL22(1), IL22RA1(4), IL22RA2(3), IL23A(1), IL23R(4), IL24(2), IL26(1), IL2RA(1), IL2RB(2), IL2RG(5), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL6ST(9), IL7(1), IL7R(7), IL9R(3), IRF9(2), JAK1(9), JAK2(8), JAK3(12), LEP(1), LEPR(8), LIF(2), LIFR(9), MPL(7), MYC(2), OSM(5), OSMR(9), PIAS1(3), PIAS2(1), PIAS3(5), PIAS4(4), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIM1(1), PRL(3), PRLR(4), PTPN11(4), PTPN6(2), SOCS3(1), SOCS4(1), SOCS5(3), SOCS7(5), SOS1(23), SOS2(8), SPRED1(4), SPRED2(6), SPRY1(3), SPRY2(5), SPRY3(3), SPRY4(4), STAM(4), STAM2(6), STAT1(13), STAT2(4), STAT3(6), STAT4(9), STAT5A(1), STAT5B(5), STAT6(9), TPO(16), TSLP(3), TYK2(9) 84415300 784 302 711 198 379 27 138 91 145 4 0.0110 1.000 1.000 150 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRB1(3), ADRB2(3), ANXA6(6), ARRB1(4), ARRB2(4), ATP1A4(11), ATP1B1(1), ATP1B2(5), ATP1B3(1), ATP2A2(10), ATP2A3(5), ATP2B1(11), ATP2B2(13), ATP2B3(3), CACNA1A(25), CACNA1B(17), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1S(12), CACNB1(5), CACNB3(5), CALM1(2), CALM2(2), CALR(4), CAMK1(5), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CASQ1(7), CASQ2(5), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), GJA1(3), GJA4(2), GJA5(5), GJB2(2), GJB3(3), GJB5(4), GJB6(2), GNA11(3), GNAI2(5), GNAI3(6), GNAO1(2), GNAQ(3), GNAZ(3), GNB1(7), GNB3(5), GNB4(5), GNB5(2), GNG12(2), GNG2(1), GNG3(3), GNG4(5), GNG5(1), GRK4(2), GRK5(5), GRK6(4), ITPR1(21), ITPR2(33), ITPR3(9), KCNB1(8), KCNJ3(4), KCNJ5(2), MIB1(9), NME7(3), PEA15(2), PKIA(2), PKIB(1), PKIG(3), PLCB3(11), PLN(2), PRKACA(2), PRKACB(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), RGS1(1), RGS10(4), RGS11(1), RGS14(5), RGS16(4), RGS17(1), RGS18(6), RGS19(3), RGS2(1), RGS20(3), RGS3(3), RGS4(2), RGS5(3), RGS6(5), RGS7(8), RGS9(6), RYR1(54), RYR2(83), RYR3(53), SFN(1), SLC8A1(8), SLC8A3(5), USP5(3), YWHAB(2), YWHAH(2), YWHAQ(3) 108011816 909 296 895 421 420 44 219 95 130 1 1.000 1.000 1.000 151 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(7), ATM(65), ATR(32), BAI1(5), BAX(1), BID(2), CASP3(3), CASP8(14), CASP9(6), CCNB1(5), CCNB3(9), CCND1(4), CCND2(1), CCND3(5), CCNE1(3), CCNE2(7), CCNG1(2), CCNG2(4), CD82(3), CDK2(1), CDK4(5), CDK6(5), CDKN1A(38), CDKN2A(30), CHEK1(3), CHEK2(11), CYCS(1), DDB2(8), EI24(1), FAS(1), GADD45A(1), GADD45G(1), GTSE1(5), IGF1(2), IGFBP3(1), MDM2(6), MDM4(2), PERP(2), PPM1D(5), PTEN(16), RCHY1(2), RFWD2(6), RPRM(3), RRM2(3), RRM2B(2), SERPINB5(3), SERPINE1(6), SESN1(8), SESN2(2), SESN3(11), SFN(1), SIAH1(2), STEAP3(3), THBS1(8), TNFRSF10B(6), TP53(226), TP53I3(4), TP73(6), TSC2(11), ZMAT3(3) 37787823 639 294 505 109 253 23 140 50 164 9 7.83e-06 1.000 1.000 152 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(7), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADM(3), ARRB1(4), ARRB2(4), ATF1(2), ATF2(1), ATF4(3), ATP2A2(10), ATP2A3(5), CACNB3(5), CALCA(1), CALM1(2), CALM2(2), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CNN1(3), CNN2(3), CORIN(7), CRHR1(2), DGKZ(3), ETS2(5), FOS(4), GABPA(6), GABPB2(2), GBA2(1), GJA1(3), GNAQ(3), GNB1(7), GNB3(5), GNB4(5), GNB5(2), GNG12(2), GNG2(1), GNG3(3), GNG4(5), GNG5(1), GRK4(2), GRK5(5), GRK6(4), GSTO1(2), GUCY1A3(12), IGFBP1(4), IGFBP3(1), IGFBP4(1), IGFBP6(2), IL1B(3), IL6(4), ITPR1(21), ITPR2(33), ITPR3(9), JUN(4), MIB1(9), MYL2(4), MYLK2(7), NFKB1(3), NOS1(15), NOS3(11), OXT(1), OXTR(1), PDE4B(5), PDE4D(4), PKIA(2), PKIB(1), PKIG(3), PLCB3(11), PLCD1(5), PLCG1(12), PLCG2(6), PRKACA(2), PRKACB(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), RAMP1(2), RAMP2(1), RAMP3(2), RGS1(1), RGS10(4), RGS11(1), RGS14(5), RGS16(4), RGS17(1), RGS18(6), RGS19(3), RGS2(1), RGS20(3), RGS3(3), RGS4(2), RGS5(3), RGS6(5), RGS7(8), RGS9(6), RLN1(2), RYR1(54), RYR2(83), RYR3(53), SFN(1), SLC8A1(8), SP1(10), TNXB(38), USP5(3), YWHAB(2), YWHAH(2), YWHAQ(3) 99781943 837 293 823 350 398 40 194 81 122 2 0.998 1.000 1.000 153 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), ACVR1B(2), ACVR1C(3), BAIAP2(5), CDC42(4), CDH1(15), CREBBP(50), CSNK2A1(11), CSNK2B(5), CTNNA1(6), CTNNA2(21), CTNNA3(11), CTNNB1(15), CTNND1(10), EGFR(7), EP300(77), ERBB2(54), FARP2(7), FER(12), FGFR1(6), FYN(7), IGF1R(11), INSR(10), IQGAP1(11), LEF1(4), LMO7(13), MAP3K7(8), MAPK3(8), MET(19), MLLT4(15), NLK(6), PARD3(22), PTPN1(5), PTPN6(2), PTPRB(16), PTPRF(14), PTPRJ(8), PTPRM(17), PVRL1(10), PVRL2(5), PVRL3(5), PVRL4(4), RAC1(4), RAC2(1), RAC3(3), RHOA(19), SMAD2(4), SMAD3(6), SMAD4(8), SNAI1(4), SNAI2(3), SORBS1(10), SRC(5), SSX2IP(3), TCF7(1), TCF7L2(1), TGFBR1(7), TGFBR2(8), TJP1(9), VCL(4), WAS(4), WASF1(5), WASF2(7), WASF3(5), WASL(2), YES1(6) 69697310 732 292 676 181 338 38 139 78 134 5 0.0245 1.000 1.000 154 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(4), CADM1(6), CADM3(4), CD2(2), CD22(4), CD226(5), CD274(5), CD276(1), CD28(3), CD34(3), CD4(3), CD40(3), CD40LG(2), CD58(1), CD6(3), CD80(2), CD86(6), CD8A(2), CD99(2), CDH1(15), CDH15(8), CDH2(12), CDH3(7), CDH4(18), CDH5(9), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CNTN1(11), CNTN2(9), CNTNAP1(12), CNTNAP2(25), CTLA4(1), ESAM(1), F11R(5), GLG1(9), HLA-A(7), HLA-B(4), HLA-C(4), HLA-DMB(4), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(6), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(5), HLA-F(5), HLA-G(3), ICAM1(7), ICAM2(1), ICAM3(5), ICOS(2), ICOSLG(3), ITGA4(19), ITGA6(9), ITGA8(20), ITGA9(9), ITGAL(17), ITGAM(13), ITGAV(13), ITGB1(3), ITGB2(7), ITGB7(3), ITGB8(11), JAM2(1), JAM3(4), L1CAM(8), MADCAM1(1), MAG(4), MPZ(5), MPZL1(3), NCAM1(9), NCAM2(16), NEGR1(2), NEO1(12), NFASC(11), NLGN1(11), NLGN2(3), NLGN3(6), NRCAM(16), NRXN1(24), NRXN2(11), NRXN3(10), OCLN(4), PDCD1(3), PDCD1LG2(3), PTPRC(19), PTPRF(14), PTPRM(17), PVR(4), PVRL1(10), PVRL2(5), PVRL3(5), SDC1(4), SDC2(3), SDC3(2), SDC4(1), SELE(7), SELP(7), SELPLG(3), SIGLEC1(12), SPN(6), VCAM1(14), VCAN(37) 85441016 774 288 761 263 353 40 171 92 117 1 0.734 1.000 1.000 155 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(2), BID(2), BRAF(9), CASP3(3), CD244(6), CD247(1), CD48(1), FAS(1), FASLG(1), FCER1G(1), FCGR3A(6), FYN(7), GRB2(1), GZMB(2), HCST(1), HLA-A(7), HLA-B(4), HLA-C(4), HLA-E(5), HLA-G(3), HRAS(16), ICAM1(7), ICAM2(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(5), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), ITGAL(17), ITGB2(7), KIR2DL3(2), KIR3DL1(7), KIR3DL2(1), KLRC2(2), KLRC3(4), KLRD1(1), KLRK1(2), KRAS(13), LAT(1), LCK(2), LCP2(5), MAP2K1(3), MAP2K2(5), MAPK3(8), MICA(2), MICB(3), NCR1(4), NCR2(4), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NRAS(7), PAK1(4), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRF1(7), PRKCA(3), PRKCG(6), PTK2B(6), PTPN11(4), PTPN6(2), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SH2D1A(1), SH2D1B(3), SH3BP2(2), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SYK(8), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFSF10(5), TYROBP(1), ULBP1(2), ULBP3(2), VAV1(8), VAV2(8), VAV3(7), ZAP70(2) 65745066 621 285 542 189 319 22 132 71 76 1 0.287 1.000 1.000 156 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(7), ACVR1B(2), ACVR2A(3), ACVR2B(2), AMHR2(2), BMP2(1), BMP7(4), BMPR1A(3), BMPR1B(4), BMPR2(9), CCL1(3), CCL13(2), CCL14(2), CCL15(1), CCL16(1), CCL17(1), CCL2(1), CCL21(2), CCL22(2), CCL23(1), CCL25(2), CCL26(1), CCL27(1), CCL28(1), CCL3(2), CCL5(1), CCL7(2), CCR1(1), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(4), CCR9(1), CD27(6), CD40(3), CD40LG(2), CD70(1), CLCF1(3), CNTF(5), CNTFR(1), CRLF2(2), CSF1(4), CSF1R(11), CSF2RA(7), CSF2RB(5), CSF3(1), CSF3R(4), CX3CL1(9), CX3CR1(4), CXCL1(1), CXCL10(2), CXCL11(1), CXCL13(2), CXCL14(2), CXCL2(1), CXCL5(1), CXCL6(1), CXCL9(3), CXCR3(3), CXCR4(4), CXCR6(4), EDA(6), EDA2R(1), EDAR(3), EGF(17), EGFR(7), EPO(2), EPOR(5), FAS(1), FASLG(1), FLT1(8), FLT3(10), FLT3LG(1), FLT4(10), GDF5(2), GH1(3), GH2(3), GHR(6), HGF(12), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(5), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IFNK(4), IFNW1(2), IL10(1), IL10RA(9), IL10RB(8), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL13RA1(2), IL15(1), IL15RA(1), IL17A(2), IL17B(3), IL17RA(4), IL17RB(2), IL18R1(4), IL18RAP(9), IL19(2), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), IL1RAP(5), IL2(1), IL20(1), IL20RA(6), IL21(3), IL21R(8), IL22(1), IL22RA1(4), IL22RA2(3), IL23A(1), IL23R(4), IL24(2), IL26(1), IL2RA(1), IL2RB(2), IL2RG(5), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL6ST(9), IL7(1), IL7R(7), IL9R(3), INHBA(3), INHBB(3), INHBC(1), INHBE(6), KDR(19), KIT(9), KITLG(5), LEP(1), LEPR(8), LIF(2), LIFR(9), LTA(1), LTB(3), LTBR(3), MET(19), MPL(7), NGFR(4), OSM(5), OSMR(9), PDGFB(2), PDGFC(5), PDGFRA(16), PDGFRB(7), PF4V1(2), PLEKHO2(5), PPBP(2), PRL(3), PRLR(4), RELT(1), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFRSF11A(1), TNFRSF11B(3), TNFRSF13B(1), TNFRSF13C(3), TNFRSF14(2), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(5), TNFRSF1B(6), TNFRSF21(5), TNFRSF25(3), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(8), TNFRSF9(2), TNFSF10(5), TNFSF11(1), TNFSF13(2), TNFSF13B(5), TNFSF14(1), TNFSF18(4), TNFSF4(1), TNFSF8(4), TNFSF9(2), TPO(16), TSLP(3), VEGFA(4), VEGFB(3), VEGFC(6), XCL2(1) 102687070 789 282 785 270 366 27 177 95 122 2 0.684 1.000 1.000 157 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADRB1(3), CSNK1D(3), DRD1(2), DRD2(5), EGF(17), EGFR(7), GJA1(3), GJD2(4), GNA11(3), GNAI1(4), GNAI2(5), GNAI3(6), GNAQ(3), GNAS(12), GRB2(1), GRM1(22), GRM5(18), GUCY1A2(11), GUCY1A3(12), GUCY1B3(8), GUCY2C(14), GUCY2D(6), GUCY2F(10), HRAS(16), HTR2A(2), HTR2B(5), HTR2C(1), ITPR1(21), ITPR2(33), ITPR3(9), KRAS(13), MAP2K1(3), MAP2K2(5), MAP2K5(4), MAP3K2(6), MAPK3(8), MAPK7(3), NPR1(8), NPR2(6), NRAS(7), PDGFB(2), PDGFC(5), PDGFD(8), PDGFRA(16), PDGFRB(7), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKG1(8), PRKG2(8), PRKX(1), RAF1(4), SOS1(23), SOS2(8), SRC(5), TJP1(9), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(3) 76853148 646 281 619 243 302 29 172 70 73 0 0.893 1.000 1.000 158 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(7), ACTN2(10), ACTN4(13), ARHGAP5(12), BCAR1(6), CD99(2), CDC42(4), CDH5(9), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CTNNA1(6), CTNNA2(21), CTNNA3(11), CTNNB1(15), CTNND1(10), CXCR4(4), CYBA(2), CYBB(1), ESAM(1), EZR(12), F11R(5), GNAI1(4), GNAI2(5), GNAI3(6), ICAM1(7), ITGA4(19), ITGAL(17), ITGAM(13), ITGB1(3), ITGB2(7), ITK(6), JAM2(1), JAM3(4), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MLLT4(15), MMP2(7), MMP9(6), MSN(1), MYL2(4), MYL5(2), NCF1(1), NCF2(6), NCF4(3), NOX1(4), NOX3(5), OCLN(4), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PRKCA(3), PRKCG(6), PTK2(12), PTK2B(6), PTPN11(4), PXN(3), RAC1(4), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(6), RAPGEF4(9), RASSF5(2), RHOA(19), RHOH(3), ROCK1(8), ROCK2(15), SIPA1(5), THY1(3), TXK(10), VASP(1), VAV1(8), VAV2(8), VAV3(7), VCAM1(14), VCL(4) 71941691 673 277 601 181 352 29 135 78 79 0 0.0198 1.000 1.000 159 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ASIP(1), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CREB3L2(5), CREB3L3(7), CREB3L4(7), CREBBP(50), CTNNB1(15), DCT(8), DVL1(5), DVL2(9), DVL3(4), EDN1(2), EDNRB(8), EP300(77), FZD1(4), FZD10(9), FZD2(3), FZD3(6), FZD4(2), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GNAI1(4), GNAI2(5), GNAI3(6), GNAO1(2), GNAQ(3), GNAS(12), GSK3B(4), HRAS(16), KIT(9), KITLG(5), KRAS(13), LEF1(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MC1R(2), MITF(7), NRAS(7), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), POMC(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKX(1), RAF1(4), TCF7(1), TCF7L2(1), TYR(12), TYRP1(2), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(3), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2) 63097402 606 273 574 220 256 27 157 66 98 2 0.741 1.000 1.000 160 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(4), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADK(3), ADSL(4), ADSS(4), ADSSL1(4), AK1(1), AK2(3), AK5(3), AK7(6), ALLC(3), AMPD1(10), AMPD2(6), AMPD3(4), APRT(1), ATIC(2), CANT1(1), DCK(4), DGUOK(1), ENPP1(7), ENPP3(5), ENTPD1(1), ENTPD2(2), ENTPD3(5), ENTPD5(4), ENTPD6(2), ENTPD8(5), FHIT(4), GART(7), GDA(7), GMPR(2), GMPR2(3), GMPS(5), GUCY1A2(11), GUCY1A3(12), GUCY1B3(8), GUCY2C(14), GUCY2D(6), GUCY2F(10), GUK1(3), HPRT1(1), IMPDH1(1), IMPDH2(1), ITPA(1), NME1(1), NME2(1), NME4(1), NME6(1), NME7(3), NPR1(8), NPR2(6), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), NUDT5(3), NUDT9(4), PAICS(4), PAPSS1(4), PAPSS2(2), PDE10A(8), PDE11A(19), PDE1A(8), PDE1C(15), PDE2A(2), PDE3B(9), PDE4A(12), PDE4B(5), PDE4C(8), PDE4D(4), PDE5A(11), PDE6H(1), PDE7A(3), PDE7B(2), PDE8A(4), PDE8B(4), PDE9A(7), PFAS(7), PKLR(8), PNPT1(10), POLA1(8), POLA2(11), POLD1(8), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLR1A(18), POLR1B(4), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2), PPAT(4), PRIM2(1), PRPS1(3), PRPS1L1(4), PRPS2(1), PRUNE(8), RFC5(5), RRM1(4), RRM2(3), RRM2B(2), XDH(11) 94682952 693 270 681 261 357 35 146 61 92 2 0.985 1.000 1.000 161 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(9), ACTN1(7), ACTR2(3), ACTR3(2), AKT1(3), AKT2(4), AKT3(6), ANGPTL2(3), ARHGEF6(7), ARHGEF7(9), BCAR1(6), BRAF(9), CDC42(4), CDKN2A(30), CRK(4), CSE1L(12), DOCK1(11), EPHB2(10), FYN(7), GRB2(1), GRB7(1), ILK(3), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGB3BP(2), MAP2K4(4), MAP2K7(3), MAP3K11(1), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MRAS(2), MYLK(15), MYLK2(7), P4HB(6), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PIK3CA(94), PIK3CB(11), PKLR(8), PLCG1(12), PLCG2(6), PTEN(16), PTK2(12), RAF1(4), RALA(2), RHO(3), ROCK1(8), ROCK2(15), SHC1(8), SOS1(23), SOS2(8), SRC(5), TERF2IP(4), TLN1(17), TLN2(13), VASP(1), WAS(4), ZYX(4) 70782261 653 270 580 161 342 30 107 83 90 1 0.0122 1.000 1.000 162 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(7), ACTN2(10), ACTN4(13), DES(2), DMD(41), MYBPC1(16), MYBPC2(8), MYBPC3(5), MYH3(19), MYH6(14), MYH7(19), MYH8(17), MYL2(4), MYOM1(17), NEB(53), TCAP(1), TMOD1(4), TNNC2(1), TNNI1(5), TNNI2(2), TNNI3(1), TNNT1(7), TNNT2(1), TNNT3(1), TPM1(3), TPM2(2), TPM3(1), TPM4(3), TTN(357), VIM(7) 78391260 645 270 640 197 314 27 142 92 64 6 0.900 1.000 1.000 163 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(7), BAD(2), BAK1(2), BAX(1), BCL2L1(4), BCL2L11(3), BID(2), BIRC2(3), BIRC3(3), BIRC5(2), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CHUK(7), CYCS(1), DFFA(6), FADD(7), FAS(1), FASLG(1), GZMB(2), HELLS(5), IKBKB(11), IRF1(1), IRF2(6), IRF3(5), IRF4(3), IRF5(4), IRF6(4), IRF7(3), JUN(4), LTA(1), MAP2K4(4), MAP3K1(10), MAPK10(9), MDM2(6), MYC(2), NFKB1(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PLEKHG5(6), PRF1(7), RELA(6), RIPK1(7), TNF(4), TNFRSF10B(6), TNFRSF1A(5), TNFRSF1B(6), TNFRSF21(5), TNFRSF25(3), TNFSF10(5), TP53(226), TP73(6), TRADD(2), TRAF2(5), TRAF3(2) 33184169 501 268 386 99 210 17 128 36 108 2 0.000177 1.000 1.000 164 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(3), AKT2(4), AKT3(6), BCL10(3), CARD11(14), CBL(8), CBLB(13), CBLC(3), CD247(1), CD28(3), CD3E(2), CD3G(2), CD4(3), CD40LG(2), CD8A(2), CDC42(4), CDK4(5), CHUK(7), CTLA4(1), FOS(4), FYN(7), GRAP2(3), GRB2(1), HRAS(16), ICOS(2), IFNG(2), IKBKB(11), IL10(1), IL2(1), IL5(1), ITK(6), JUN(4), KRAS(13), LAT(1), LCK(2), LCP2(5), MALT1(8), MAP3K8(5), NCK1(2), NCK2(5), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NRAS(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PDCD1(3), PDK1(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRKCQ(10), PTPN6(2), PTPRC(19), RASGRP1(6), RHOA(19), SOS1(23), SOS2(8), TEC(10), TNF(4), VAV1(8), VAV2(8), VAV3(7), ZAP70(2) 58939510 608 267 525 151 324 23 124 67 70 0 0.0205 1.000 1.000 165 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(6), ADCY8(18), ARAF(2), ATF4(3), BRAF(9), CACNA1C(14), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CREBBP(50), EP300(77), GNAQ(3), GRIA1(16), GRIA2(7), GRIN1(7), GRIN2A(14), GRIN2B(10), GRIN2C(10), GRIN2D(9), GRM1(22), GRM5(18), HRAS(16), ITPR1(21), ITPR2(33), ITPR3(9), KRAS(13), MAP2K1(3), MAP2K2(5), MAPK3(8), NRAS(7), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKX(1), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF3(6), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA6(11) 57533505 585 267 556 199 237 31 139 73 103 2 0.707 1.000 1.000 166 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(2), BRAF(9), CACNA1A(25), CRHR1(2), GNA11(3), GNA12(3), GNA13(12), GNAI1(4), GNAI2(5), GNAI3(6), GNAO1(2), GNAQ(3), GNAS(12), GNAZ(3), GRIA1(16), GRIA2(7), GRIA3(6), GRID2(12), GRM1(22), GRM5(18), GUCY1A2(11), GUCY1A3(12), GUCY1B3(8), GUCY2C(14), GUCY2D(6), GUCY2F(10), HRAS(16), IGF1(2), IGF1R(11), ITPR1(21), ITPR2(33), ITPR3(9), KRAS(13), LYN(5), MAP2K1(3), MAP2K2(5), MAPK3(8), NOS1(15), NOS3(11), NPR1(8), NPR2(6), NRAS(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(3), PPP2R2C(4), PRKCA(3), PRKCG(6), PRKG1(8), PRKG2(8), RAF1(4), RYR1(54) 63815252 579 267 553 210 274 21 155 65 63 1 0.821 1.000 1.000 167 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALM2(2), CALML3(1), CALML6(3), CDIPT(2), CDS1(5), CDS2(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), FN3K(2), IMPA1(1), IMPA2(4), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPP5B(4), INPP5D(5), INPP5E(1), INPPL1(11), ITPK1(4), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), OCRL(4), PI4KA(11), PI4KB(13), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3C3(11), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLCD1(5), PLCD3(6), PLCD4(5), PLCE1(10), PLCG1(12), PLCG2(6), PLCZ1(5), PRKCA(3), PRKCG(6), PTEN(16), PTPMT1(2), SYNJ1(20), SYNJ2(8) 71982084 633 263 567 205 348 26 117 63 79 0 0.529 1.000 1.000 168 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(6), APOA1(2), APOA2(4), CD36(2), CITED2(3), CPT1B(4), CREBBP(50), DUSP1(3), DUT(2), EHHADH(6), EP300(77), FABP1(2), HSD17B4(5), HSPA1A(3), JUN(4), LPL(4), MAPK3(8), ME1(5), MRPL11(2), MYC(2), NCOA1(24), NCOR1(41), NCOR2(19), NFKBIA(6), NR0B2(2), NR1H3(3), NR2F1(3), NRIP1(7), PIK3CA(94), PIK3R1(6), PPARA(1), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PTGS2(6), RB1(73), RELA(6), RXRA(25), SP1(10), STAT5A(1), STAT5B(5), TNF(4) 36680787 553 263 464 100 240 20 70 54 161 8 1.84e-05 1.000 1.000 169 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BAK1(2), BAX(1), BFAR(7), BTK(5), CAD(15), CASP10(1), CASP3(3), CASP8(14), CD7(3), CSNK1A1(6), DAXX(9), DEDD(5), DFFA(6), DIABLO(3), EGFR(7), EPHB2(10), FADD(7), FAF1(4), HSPB1(1), IL1A(1), MAP2K4(4), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MET(19), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NR0B2(2), PFN1(4), PFN2(1), PTPN13(19), RALBP1(2), RIPK1(7), ROCK1(8), SMPD1(4), TNFRSF6B(1), TP53(226), TPX2(7), TRAF2(5) 41985811 524 263 413 107 214 11 145 42 110 2 0.000686 1.000 1.000 170 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(20), BAD(2), CABIN1(10), CALM1(2), CALM2(2), CAMK2B(5), CAMK4(4), CD3E(2), CD3G(2), CDKN1A(38), CEBPB(3), CNR1(4), CREBBP(50), CSNK2A1(11), CSNK2B(5), CTLA4(1), EGR2(3), EGR3(3), EP300(77), FCER1A(5), FCGR3A(6), FOS(4), FOSL1(3), GATA3(8), GATA4(1), GSK3A(2), GSK3B(4), HRAS(16), ICOS(2), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL1B(3), IL2(1), IL2RA(1), IL6(4), ITK(6), JUNB(5), KPNA5(5), MAP2K7(3), MAPK14(2), MAPK8(5), MAPK9(5), MEF2A(7), MEF2B(3), MEF2D(3), MYF5(9), NCK2(5), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NFKB2(3), NFKBIB(6), NFKBIE(7), NPPB(1), NUP214(17), OPRD1(5), P2RX7(5), PAK1(4), PPIA(1), PPP3CB(6), PPP3CC(4), PPP3R1(1), PTPRC(19), RELA(6), SFN(1), SLA(2), SP1(10), SP3(3), TGFB1(2), TNF(4), TRAF2(5), TRPV6(5), VAV1(8), VAV2(8), VAV3(7), XPO5(10) 52836945 573 261 547 153 229 23 119 50 145 7 0.214 1.000 1.000 171 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), ATF2(1), CDC42(4), DLD(7), DUSP10(4), DUSP4(2), DUSP8(6), GAB1(6), GADD45A(1), GCK(1), IL1R1(1), JUN(4), MAP2K4(4), MAP2K5(4), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K11(1), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K7(8), MAP3K9(11), MAPK10(9), MAPK7(3), MAPK8(5), MAPK9(5), MYEF2(5), NFATC3(10), NR2C2(6), PAPPA(15), SHC1(8), TP53(226), TRAF6(1), ZAK(10) 29209597 454 260 343 83 172 14 135 35 96 2 0.000441 1.000 1.000 172 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(3), AKT2(4), AKT3(6), BAD(2), BCL2L1(4), CDC42(4), CDK2(1), CDKN1B(6), CDKN2A(30), CREB5(10), EBP(1), ERBB4(11), F2RL2(2), GAB1(6), GADD45A(1), GRB2(1), GSK3A(2), GSK3B(4), IGF1(2), IGFBP1(4), INPPL1(11), IRS1(9), IRS2(5), IRS4(18), MET(19), MYC(2), NOLC1(3), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PARD3(22), PARD6A(7), PDK1(2), PIK3CA(94), PIK3CD(7), PPP1R13B(7), PREX1(14), PTEN(16), PTK2(12), PTPN1(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(8), SLC2A4(4), SOS1(23), SOS2(8), TSC1(34), TSC2(11), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 44922071 526 259 449 111 260 18 95 51 99 3 0.00149 1.000 1.000 173 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(7), ACVR1B(2), ACVR1C(3), ACVR2A(3), ACVR2B(2), ACVRL1(5), AMHR2(2), BMP2(1), BMP4(1), BMP5(6), BMP6(5), BMP7(4), BMP8B(3), BMPR1A(3), BMPR1B(4), BMPR2(9), CDKN2B(2), CHRD(7), COMP(8), CREBBP(50), CUL1(19), DCN(3), E2F4(2), E2F5(3), EP300(77), FST(4), GDF5(2), GDF6(4), ID1(7), ID2(1), ID3(1), IFNG(2), INHBA(3), INHBB(3), INHBC(1), INHBE(6), LEFTY2(2), LTBP1(20), MAPK3(8), MYC(2), NODAL(3), NOG(2), PITX2(5), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(3), PPP2R2C(4), RBL1(9), RBL2(9), RBX1(1), RHOA(19), ROCK1(8), ROCK2(15), RPS6KB1(4), RPS6KB2(1), SKP1(6), SMAD1(6), SMAD2(4), SMAD3(6), SMAD4(8), SMAD6(2), SMAD7(3), SMAD9(3), SMURF1(8), SMURF2(8), SP1(10), TFDP1(2), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNF(4), ZFYVE16(14), ZFYVE9(26) 57515988 556 258 535 165 237 24 119 56 116 4 0.720 1.000 1.000 174 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ATF4(3), CACNA1C(14), CACNA1D(18), CACNA1F(11), CACNA1S(12), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CDC42(4), CGA(2), EGFR(7), ELK1(1), FSHB(1), GNA11(3), GNAQ(3), GNAS(12), GNRH1(3), GNRHR(2), GRB2(1), HBEGF(1), HRAS(16), ITPR1(21), ITPR2(33), ITPR3(9), JUN(4), KRAS(13), LHB(2), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK7(3), MAPK8(5), MAPK9(5), MMP14(4), MMP2(7), NRAS(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLD1(9), PLD2(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCD(8), PRKX(1), PTK2B(6), RAF1(4), SOS1(23), SOS2(8), SRC(5) 73445578 582 258 556 267 268 24 148 65 77 0 1.000 1.000 1.000 175 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(7), ACVR1B(2), ACVRL1(5), AKT1(3), AURKB(2), BMPR1A(3), BMPR2(9), BUB1(18), CDIPT(2), CDKL1(2), CDKL2(5), CDS1(5), CDS2(3), CLK1(7), CLK2(10), CLK4(3), COL4A3BP(8), CSNK2A1(11), CSNK2B(5), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), IMPA1(1), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPPL1(11), ITPKA(4), ITPKB(5), MAP3K10(2), MOS(2), NEK1(5), NEK3(4), OCRL(4), PAK4(1), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3CA(94), PIK3CB(11), PIK3CG(10), PIM2(3), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLCD1(5), PLCG1(12), PLCG2(6), PLK3(10), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), PRKG1(8), RAF1(4), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA4(3), RPS6KB1(4), TGFBR1(7), VRK1(3) 65148191 611 255 547 191 322 34 99 76 78 2 0.555 1.000 1.000 176 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), AKAP1(8), AKAP10(6), AKAP11(15), AKAP12(11), AKAP2(2), AKAP3(6), AKAP4(2), AKAP5(3), AKAP6(29), AKAP7(3), AKAP8(3), AKAP9(48), ARHGEF1(8), CALM1(2), CALM2(2), CHMP1B(3), GNA11(3), GNA12(3), GNA13(12), GNA14(3), GNA15(5), GNAI2(5), GNAI3(6), GNAL(4), GNAO1(2), GNAQ(3), GNAZ(3), GNB1(7), GNB3(5), GNB5(2), GNG12(2), GNG3(3), GNG4(5), GNG5(1), GNGT2(1), HRAS(16), IL18BP(2), ITPR1(21), KCNJ3(4), KRAS(13), NRAS(7), PALM2(3), PDE1A(8), PDE1B(4), PDE1C(15), PDE4A(12), PDE4B(5), PDE4C(8), PDE4D(4), PDE7A(3), PDE7B(2), PDE8A(4), PDE8B(4), PLCB3(11), PPP3CA(7), PPP3CC(4), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PRKD1(12), PRKD3(13), RHOA(19), RRAS(2), SLC9A1(7), USP5(3) 67981034 608 253 572 198 306 29 128 67 77 1 0.692 1.000 1.000 177 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), AKT2(4), AKT3(6), BAD(2), CASP9(6), CDC42(4), HRAS(16), KDR(19), KRAS(13), MAP2K1(3), MAP2K2(5), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPKAPK2(1), MAPKAPK3(3), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NOS3(11), NRAS(7), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCG1(12), PLCG2(6), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRKCA(3), PRKCG(6), PTGS2(6), PTK2(12), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SH2D2A(6), SHC2(3), SPHK1(1), SPHK2(10), SRC(5), VEGFA(4) 41681082 450 249 375 112 226 19 101 51 53 0 0.0118 1.000 1.000 178 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(6), BCAR1(6), CAPN1(5), CAPN10(2), CAPN11(2), CAPN2(2), CAPN3(7), CAPN5(4), CAPN6(3), CAPN7(4), CAPN9(6), CAV2(1), CAV3(1), CDC42(4), CRK(4), CSK(7), DOCK1(11), FYN(7), GIT2(5), GRB2(1), ILK(3), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAD(4), ITGAE(11), ITGAL(17), ITGAM(13), ITGAV(13), ITGAX(3), ITGB1(3), ITGB2(7), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAPK10(9), MAPK12(2), MAPK4(5), MAPK6(4), MAPK7(3), MYLK2(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PDPK1(2), PIK3R2(4), PTK2(12), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAP1B(2), RAPGEF1(6), RHO(3), ROCK1(8), ROCK2(15), SDCCAG8(9), SEPP1(3), SHC1(8), SHC3(1), SORBS1(10), SOS1(23), SRC(5), TLN1(17), TNS1(20), VASP(1), VAV2(8), VAV3(7), VCL(4), ZYX(4) 77266507 592 246 588 205 288 26 126 77 75 0 0.882 1.000 1.000 179 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRA2A(3), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(4), AVPR1B(3), AVPR2(3), BDKRB1(4), BDKRB2(2), BRS3(4), C3AR1(4), CCKAR(3), CCKBR(8), CCR1(1), CCR10(3), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(4), CCR9(1), CCRL2(4), CHML(6), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CMKLR1(3), CNR1(4), CNR2(6), CX3CR1(4), CXCR3(3), CXCR4(4), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), EDNRA(4), EDNRB(8), F2R(2), F2RL1(5), F2RL2(2), F2RL3(2), FPR1(3), FSHR(5), GALR1(3), GALR2(4), GALR3(3), GALT(1), GHSR(6), GNB2L1(3), GPR17(3), GPR173(2), GPR174(4), GPR27(1), GPR35(2), GPR37(6), GPR37L1(5), GPR4(4), GPR50(15), GPR6(5), GPR63(3), GPR83(3), GPR85(4), GPR87(3), GRPR(1), HCRTR1(1), HCRTR2(10), HRH1(9), HRH2(1), HRH3(4), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), LHCGR(7), MAS1(2), MC1R(2), MC3R(4), MC4R(3), MC5R(3), MLNR(3), MTNR1A(4), MTNR1B(1), NMBR(6), NMUR2(1), NPY1R(7), NPY2R(4), NPY5R(5), NTSR1(2), NTSR2(2), OPN1SW(3), OPN3(1), OPRD1(5), OPRK1(4), OPRL1(2), OR10A5(2), OR11A1(4), OR12D3(1), OR1C1(2), OR1F1(2), OR1Q1(2), OR2H1(3), OR5V1(5), OR7A5(6), OR7C1(6), OR8B8(3), OXTR(1), P2RY1(3), P2RY10(2), P2RY11(1), P2RY12(2), P2RY13(3), P2RY14(2), P2RY2(1), P2RY6(2), PTAFR(1), PTGDR(3), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2), RGR(3), RHO(3), RRH(4), SSTR1(3), SSTR3(4), SSTR4(6), SUCNR1(3), TRHR(9) 70712238 542 245 537 304 221 28 162 72 59 0 0.997 1.000 1.000 180 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(3), AKT2(4), AKT3(6), CASP8(14), CCL3(2), CCL5(1), CD14(3), CD40(3), CD80(2), CD86(6), CHUK(7), CXCL10(2), CXCL11(1), CXCL9(3), FADD(7), FOS(4), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(5), IFNB1(1), IKBKB(11), IKBKE(6), IL12A(1), IL12B(3), IL1B(3), IL6(4), IRAK1(3), IRAK4(7), IRF3(5), IRF5(4), IRF7(3), JUN(4), LBP(2), LY96(1), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K7(8), MAP3K8(5), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK8(5), MAPK9(5), MYD88(1), NFKB1(3), NFKB2(3), NFKBIA(6), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), RAC1(4), RELA(6), RIPK1(7), SPP1(2), STAT1(13), TBK1(7), TICAM1(9), TLR1(3), TLR2(3), TLR3(10), TLR4(6), TLR5(11), TLR6(6), TLR7(9), TLR8(9), TLR9(6), TNF(4), TOLLIP(3), TRAF3(2), TRAF6(1) 51991140 497 243 433 140 284 22 77 50 63 1 0.0916 1.000 1.000 181 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(3), AKT2(4), AKT3(6), BCL10(3), BLNK(8), BTK(5), CARD11(14), CD19(4), CD22(4), CD72(2), CD79A(4), CD79B(2), CD81(2), CHUK(7), CR2(17), FCGR2B(2), FOS(4), GSK3B(4), HRAS(16), IKBKB(11), INPP5D(5), JUN(4), KRAS(13), LILRB3(12), LYN(5), MALT1(8), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NRAS(7), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG2(6), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PTPN6(2), RAC1(4), RAC2(1), RAC3(3), RASGRP3(5), SYK(8), VAV1(8), VAV2(8), VAV3(7) 43152671 467 243 390 110 233 22 98 52 62 0 0.00526 1.000 1.000 182 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(35), ASH2L(1), CARM1(6), CTCFL(4), DOT1L(21), EED(5), EHMT1(8), EHMT2(12), EZH1(6), EZH2(6), FBXO11(6), HCFC1(4), HSF4(4), JMJD4(3), JMJD6(3), KDM6A(107), MEN1(3), NSD1(23), OGT(5), PAXIP1(8), PPP1CA(8), PPP1CB(4), PPP1CC(2), PRDM2(18), PRDM7(5), PRDM9(13), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), RBBP5(4), SATB1(6), SETD1A(9), SETD2(32), SETD7(3), SETD8(3), SETDB1(14), SETDB2(3), SETMAR(2), SMYD3(3), STK38(7), SUV39H2(1), SUV420H1(19), SUV420H2(2), SUZ12(9), WHSC1(17), WHSC1L1(15) 68945194 492 240 470 133 233 14 61 51 127 6 0.909 1.000 1.000 183 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(19), AMY2A(3), AMY2B(9), ASCC3(22), ATP13A2(15), DDX18(11), DDX19A(4), DDX23(13), DDX4(12), DDX41(2), DDX47(2), DDX50(5), DDX51(2), DDX52(8), DDX54(9), DDX55(4), DHX58(3), ENPP1(7), ENPP3(5), ENTPD7(5), EP400(23), ERCC2(38), ERCC3(7), G6PC(2), G6PC2(2), GAA(5), GANC(7), GBA(4), GBE1(2), GCK(1), GPI(4), GUSB(3), GYS1(12), GYS2(13), HK1(15), HK2(11), HK3(8), IFIH1(8), LYZL1(1), MGAM(13), MOV10L1(7), NUDT5(3), PGM1(3), PGM3(1), PYGB(8), PYGL(4), PYGM(13), RAD54B(5), RAD54L(9), RUVBL2(2), SETX(27), SI(23), SKIV2L2(9), SMARCA2(23), SMARCA5(4), TREH(1), UGDH(5), UGP2(9), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), UXS1(3) 71874261 570 240 546 184 267 33 115 87 68 0 0.844 1.000 1.000 184 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(13), ABCA10(9), ABCA12(31), ABCA13(45), ABCA2(11), ABCA3(8), ABCA4(15), ABCA5(10), ABCA6(19), ABCA7(11), ABCA8(19), ABCA9(17), ABCB1(16), ABCB10(6), ABCB11(4), ABCB4(11), ABCB5(22), ABCB6(6), ABCB7(5), ABCB8(9), ABCB9(1), ABCC1(10), ABCC10(10), ABCC11(14), ABCC12(14), ABCC2(12), ABCC3(15), ABCC4(11), ABCC5(24), ABCC6(6), ABCC8(10), ABCC9(16), ABCD1(5), ABCD2(9), ABCD3(9), ABCD4(2), ABCG1(5), ABCG2(10), ABCG4(7), ABCG5(4), ABCG8(3), CFTR(18), TAP1(3), TAP2(1) 68236069 506 239 503 165 241 29 96 59 79 2 0.130 1.000 1.000 185 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(4), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADK(3), ADSL(4), ADSS(4), AK1(1), AK2(3), AK5(3), ALLC(3), AMPD1(10), AMPD2(6), AMPD3(4), APRT(1), ATIC(2), ATP1B1(1), ATP5A1(7), ATP5B(5), ATP5C1(4), ATP5F1(4), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5I(1), ATP5J(1), ATP5J2(2), CANT1(1), DCK(4), DGUOK(1), ENPP1(7), ENPP3(5), ENTPD1(1), ENTPD2(2), FHIT(4), GART(7), GDA(7), GMPS(5), GUCY1A2(11), GUCY1A3(12), GUCY1B3(8), GUCY2C(14), GUCY2D(6), GUCY2F(10), GUK1(3), HPRT1(1), IMPDH1(1), IMPDH2(1), ITPA(1), NME1(1), NME2(1), NPR1(8), NPR2(6), NT5C(1), NT5E(6), PAICS(4), PAPSS1(4), PAPSS2(2), PDE1A(8), PDE4A(12), PDE4B(5), PDE4C(8), PDE4D(4), PDE5A(11), PDE6B(5), PDE6C(5), PDE7B(2), PDE8A(4), PDE9A(7), PFAS(7), PKLR(8), POLD1(8), POLD2(3), POLE(27), POLG(8), POLQ(28), POLR1B(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5), PPAT(4), PRPS1(3), PRPS1L1(4), PRPS2(1), PRUNE(8), RRM1(4), RRM2(3) 74370900 544 237 535 210 264 30 120 53 75 2 0.982 1.000 1.000 186 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), AKT2(4), AKT3(6), BTK(5), FCER1A(5), FCER1G(1), FYN(7), GAB2(8), GRB2(1), HRAS(16), IL5(1), INPP5D(5), KRAS(13), LAT(1), LCP2(5), LYN(5), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK8(5), MAPK9(5), MS4A2(6), NRAS(7), PDK1(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCG1(12), PLCG2(6), PRKCA(3), PRKCD(8), PRKCE(5), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SOS1(23), SOS2(8), SYK(8), TNF(4), VAV1(8), VAV2(8), VAV3(7) 41767716 438 233 363 125 226 13 97 61 41 0 0.181 1.000 1.000 187 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), ASAH1(4), ATF1(2), BRAF(9), CAMP(1), CREB5(10), CREBBP(50), CRKL(1), DAG1(3), EGR1(7), EGR2(3), EGR3(3), EGR4(5), ELK1(1), FRS2(10), GNAQ(3), JUN(4), MAP1B(19), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), NTRK1(6), OPN1LW(5), PIK3C2G(11), PIK3CA(94), PIK3CD(7), PIK3R1(6), PTPN11(4), RPS6KA3(8), SHC1(8), SRC(5), TERF2IP(4), TH(2) 29577944 349 231 285 79 182 16 67 38 45 1 0.00963 1.000 1.000 188 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(11), APAF1(7), ARHGDIB(1), BAG4(4), BID(2), BIRC2(3), BIRC3(3), CASP2(2), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CRADD(1), CYCS(1), DAXX(9), DFFA(6), FADD(7), GSN(2), LMNA(5), LMNB1(4), LMNB2(7), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK8(5), MDM2(6), NFKB1(3), NFKBIA(6), NUMA1(14), PAK2(9), PRKCD(8), PRKDC(35), PSEN1(8), PSEN2(2), PTK2(12), RASA1(8), RB1(73), RELA(6), RIPK1(7), SPTAN1(68), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5) 39982194 432 229 422 114 202 17 53 20 134 6 0.438 1.000 1.000 189 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(3), AKT2(4), AKT3(6), BRD4(14), CAP1(7), CBL(8), CDC42(4), CDKN2A(30), F2RL2(2), FLOT1(3), FLOT2(5), GRB2(1), GSK3A(2), GSK3B(4), IGFBP1(4), INPPL1(11), IRS1(9), IRS2(5), IRS4(18), LNPEP(7), MAPK3(8), PARD3(22), PARD6A(7), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3R1(6), PTEN(16), PTPN1(5), RAF1(4), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KB1(4), SERPINB6(4), SFN(1), SHC1(8), SLC2A4(4), SORBS1(10), SOS1(23), SOS2(8), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 34604802 423 228 351 92 237 16 61 48 58 3 0.00731 1.000 1.000 190 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(4), AKT3(6), BAD(2), BCR(3), BLNK(8), BTK(5), CD19(4), CD22(4), CD81(2), CR2(17), CSK(7), DAG1(3), FLOT1(3), FLOT2(5), GRB2(1), GSK3A(2), GSK3B(4), INPP5D(5), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), MAP4K1(8), MAPK3(8), NFATC1(13), NFATC2(13), NR0B2(2), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3R1(6), PLCG2(6), PPP1R13B(7), PPP3CA(7), PPP3CB(6), PPP3CC(4), PTPRC(19), RAF1(4), SHC1(8), SOS1(23), SOS2(8), SYK(8), VAV1(8) 42972563 417 225 356 127 230 22 72 47 46 0 0.324 1.000 1.000 191 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(8), CDC40(2), CLK2(10), CLK3(2), CLK4(3), COL2A1(14), CPSF1(9), CPSF2(3), CPSF3(8), CPSF4(3), CSTF1(2), CSTF2(6), CSTF2T(5), CSTF3(4), DDIT3(1), DDX1(8), DDX20(10), DHX15(12), DHX16(9), DHX38(6), DHX8(12), DHX9(21), DICER1(19), DNAJC8(1), FUS(9), GIPC1(2), LSM2(2), LSM7(1), METTL3(22), NCBP1(2), NCBP2(1), NONO(4), NUDT21(1), NXF1(10), PABPN1(4), PAPOLA(10), PHF5A(2), POLR2A(13), PPM1G(10), PRPF18(6), PRPF3(10), PRPF4(5), PRPF4B(8), PRPF8(8), PSKH1(3), PTBP1(2), PTBP2(8), RBM17(11), RBM5(12), RNGTT(4), RNMT(4), RNPS1(1), SF3A1(6), SF3A3(7), SF3B1(24), SF3B2(5), SF3B4(3), SF3B5(2), SNRPA(6), SNRPA1(3), SNRPB(8), SNRPB2(3), SNRPD1(1), SNRPD2(1), SNRPD3(1), SNRPE(2), SNRPG(2), SNRPN(5), SPOP(6), SRPK1(2), SRPK2(6), SRRM1(5), SUPT5H(11), U2AF1(8), U2AF2(4), XRN2(7) 61451614 481 224 465 141 258 29 82 43 68 1 0.915 1.000 1.000 192 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(2), IMPA1(1), IMPA2(4), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPP5B(4), INPP5E(1), INPPL1(11), IPMK(2), ISYNA1(2), ITPK1(4), ITPKA(4), ITPKB(5), MINPP1(5), OCRL(4), PI4KA(11), PI4KB(13), PIK3C3(11), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLCD1(5), PLCD3(6), PLCD4(5), PLCE1(10), PLCG1(12), PLCG2(6), PLCZ1(5), PTEN(16), PTPMT1(2), SYNJ1(20), SYNJ2(8) 43092798 401 223 337 116 234 12 72 45 38 0 0.158 1.000 1.000 193 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(3), ALG1(2), ALG10(5), ALG10B(6), ALG11(5), ALG12(3), ALG13(4), ALG14(1), ALG2(2), ALG3(1), ALG6(3), ALG8(2), ALG9(2), B3GNT1(3), B3GNT2(5), B3GNT6(1), B3GNT7(1), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), B4GALT7(1), C1GALT1(4), C1GALT1C1(3), CHPF(4), CHST1(2), CHST11(2), CHST12(3), CHST14(3), CHST2(1), CHST4(3), CHST6(1), CHST7(2), CHSY1(9), DDOST(1), DPAGT1(6), EXT1(10), EXT2(3), EXTL1(3), EXTL2(4), EXTL3(6), FUT11(2), FUT8(7), GALNT1(5), GALNT10(2), GALNT11(4), GALNT12(4), GALNT13(5), GALNT14(3), GALNT2(7), GALNT3(5), GALNT4(3), GALNT5(6), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GALNTL5(8), GANAB(16), GCNT1(5), GCNT3(3), GCNT4(5), HS2ST1(3), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), HS6ST2(2), HS6ST3(1), MAN1A1(3), MAN1A2(6), MAN1B1(9), MAN1C1(6), MAN2A1(13), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(4), MGAT5(7), MGAT5B(7), NDST1(2), NDST2(2), NDST3(7), NDST4(13), OGT(5), RPN1(3), RPN2(5), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(8), STT3B(5), UST(4), WBSCR17(9), XYLT1(6), XYLT2(6) 63726999 423 223 418 183 211 23 84 56 48 1 0.997 1.000 1.000 194 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(9), CHUK(7), DAXX(9), ELK1(1), FOS(4), GRB2(1), HRAS(16), IKBKB(11), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K5(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K11(1), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K6(9), MAP3K7(8), MAP3K8(5), MAP3K9(11), MAP4K1(8), MAP4K2(5), MAP4K3(12), MAP4K4(7), MAP4K5(4), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK4(5), MAPK6(4), MAPK7(3), MAPK8(5), MAPK9(5), MAPKAPK2(1), MAPKAPK3(3), MAPKAPK5(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MKNK1(6), MKNK2(3), MYC(2), NFKB1(3), NFKBIA(6), PAK1(4), PAK2(9), RAC1(4), RAF1(4), RELA(6), RIPK1(7), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA4(3), RPS6KA5(9), RPS6KB1(4), RPS6KB2(1), SHC1(8), SP1(10), STAT1(13), TGFB1(2), TGFB3(1), TGFBR1(7), TRADD(2), TRAF2(5) 54792449 457 218 447 159 227 20 88 47 72 3 0.954 1.000 1.000 195 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(3), ACTR3(2), AKT1(3), AKT2(4), AKT3(6), ANGPTL2(3), ARHGAP1(1), ARHGAP4(3), ARHGEF11(10), BTK(5), CDC42(4), CFL1(1), CFL2(4), GDI1(3), GDI2(5), INPPL1(11), ITPR1(21), ITPR2(33), ITPR3(9), LIMK1(6), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3CG(10), PIK3R1(6), PITX2(5), PPP1R13B(7), PTEN(16), RACGAP1(6), RHO(3), ROCK1(8), ROCK2(15), RPS4X(4), SAG(2), WASF1(5), WASL(2) 40775820 384 218 320 101 221 14 55 47 47 0 0.0769 1.000 1.000 196 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(3), AKT1(3), CALM1(2), CALM2(2), CALR(4), CAMK1(5), CAMK1G(4), CAMK4(4), CREBBP(50), CSNK1A1(6), EDN1(2), ELSPBP1(3), F2(3), FKBP1A(1), GATA4(1), GSK3B(4), HAND1(4), HAND2(2), HRAS(16), IGF1(2), LIF(2), MAP2K1(3), MAPK14(2), MAPK3(8), MAPK8(5), MEF2C(5), MYH2(22), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NKX2-5(5), NPPA(2), PIK3CA(94), PIK3R1(6), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RAF1(4), RPS6KB1(4), SYT1(6) 29510952 371 217 302 82 175 21 77 42 54 2 0.00580 1.000 1.000 197 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(7), APH1A(3), CREBBP(50), CTBP1(4), CTBP2(7), DLL1(9), DLL3(4), DLL4(5), DTX1(5), DTX2(6), DTX3(4), DTX3L(9), DTX4(3), DVL1(5), DVL2(9), DVL3(4), EP300(77), HDAC1(4), HDAC2(3), HES1(12), JAG1(13), JAG2(1), LFNG(2), MAML1(3), MAML2(6), MAML3(5), NCOR2(19), NCSTN(10), NOTCH1(17), NOTCH2(11), NOTCH3(12), NOTCH4(14), NUMB(3), NUMBL(1), PSEN1(8), PSEN2(2), RBPJ(3), RBPJL(5), RFNG(1), SNW1(8) 39655372 374 214 364 106 150 16 78 34 92 4 0.311 1.000 1.000 198 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), AKT2(4), AKT3(6), BRAF(9), CAB39(3), DDIT4(2), EIF4B(4), EIF4EBP1(1), FIGF(2), HIF1A(6), IGF1(2), MAPK3(8), PDPK1(2), PGF(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PRKAA1(9), PRKAA2(7), RHEB(4), RICTOR(19), RPS6(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA6(11), RPS6KB1(4), RPS6KB2(1), TSC1(34), TSC2(11), ULK1(9), ULK2(9), ULK3(1), VEGFA(4), VEGFB(3), VEGFC(6) 30655982 354 210 290 82 192 14 53 39 55 1 0.0370 1.000 1.000 199 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(15), BDKRB1(4), BDKRB2(2), C1QA(3), C1R(2), C1S(8), C2(5), C3(16), C3AR1(4), C4BPA(8), C4BPB(3), C5(9), C5AR1(3), C6(9), C7(4), C8A(7), C8B(3), C8G(2), C9(8), CD46(6), CD55(2), CFB(6), CFH(13), CFI(3), CPB2(5), CR1(14), CR2(17), F10(5), F11(10), F12(3), F13A1(8), F13B(9), F2(3), F2R(2), F5(24), F7(8), F8(22), F9(3), FGA(17), FGB(5), FGG(7), KLKB1(2), KNG1(5), MASP1(8), MASP2(5), MBL2(1), PLAT(6), PLAUR(7), PLG(4), PROC(2), PROS1(14), SERPINA1(1), SERPINA5(5), SERPINC1(7), SERPIND1(6), SERPINE1(6), SERPING1(3), THBD(4), VWF(21) 52489557 414 209 408 145 187 23 104 50 50 0 0.939 1.000 1.000 200 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(20), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(5), ACSL6(1), ADIPOQ(2), ADIPOR1(8), ADIPOR2(1), AGRP(2), AKT1(3), AKT2(4), AKT3(6), CAMKK1(3), CAMKK2(5), CD36(2), CHUK(7), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), G6PC(2), G6PC2(2), IKBKB(11), IRS1(9), IRS2(5), IRS4(18), JAK1(9), JAK2(8), JAK3(12), LEP(1), LEPR(8), MAPK10(9), MAPK8(5), MAPK9(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NPY(2), PCK1(9), PCK2(2), POMC(1), PPARA(1), PPARGC1A(18), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKAG1(3), PRKCQ(10), PTPN11(4), RELA(6), RXRA(25), RXRB(3), RXRG(8), SLC2A1(4), SLC2A4(4), SOCS3(1), STAT3(6), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5), TYK2(9) 48088678 389 209 373 124 189 20 82 36 62 0 0.418 1.000 1.000 201 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(4), AKT3(6), BCR(3), BTK(5), CD19(4), CDKN2A(30), DAPP1(2), FLOT1(3), FLOT2(5), GAB1(6), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), NR0B2(2), PDK1(2), PHF11(5), PIK3CA(94), PITX2(5), PLCG2(6), PPP1R13B(7), PREX1(14), PTEN(16), PTPRC(19), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KB1(4), SAG(2), SYK(8), TEC(10), VAV1(8) 31925957 364 207 294 86 207 14 53 37 52 1 0.00807 1.000 1.000 202 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(6), CD14(3), CD19(4), CD1A(7), CD1B(3), CD1C(2), CD1D(14), CD1E(12), CD2(2), CD22(4), CD33(6), CD34(3), CD36(2), CD37(1), CD38(1), CD3E(2), CD3G(2), CD4(3), CD44(2), CD5(3), CD55(2), CD7(3), CD8A(2), CD9(3), CR1(14), CR2(17), CSF1(4), CSF1R(11), CSF2RA(7), CSF3(1), CSF3R(4), DNTT(11), EPO(2), EPOR(5), FCGR1A(2), FLT3(10), FLT3LG(1), GP5(1), GP9(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), IL11RA(2), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), IL2RA(1), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL7(1), IL7R(7), IL9R(3), ITGA1(7), ITGA2(6), ITGA2B(13), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGAM(13), ITGB3(9), KIT(9), KITLG(5), MME(13), MS4A1(5), TFRC(9), THPO(4), TNF(4), TPO(16) 47265011 394 204 392 130 157 20 104 55 58 0 0.630 1.000 1.000 203 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(4), CRK(4), CRKL(1), DOCK1(11), ELK1(1), FOS(4), GAB1(6), GRB2(1), HGF(12), HRAS(16), ITGA1(7), ITGB1(3), JUN(4), MAP2K1(3), MAP2K2(5), MAP4K1(8), MAPK3(8), MAPK8(5), MET(19), PAK1(4), PIK3CA(94), PIK3R1(6), PTEN(16), PTK2(12), PTK2B(6), PTPN11(4), PXN(3), RAF1(4), RAP1A(1), RAP1B(2), RASA1(8), SOS1(23), SRC(5), STAT3(6) 25525835 316 201 245 53 178 12 52 38 36 0 0.000182 1.000 1.000 204 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CALM2(2), CD3E(2), CD3G(2), ELK1(1), FOS(4), FYN(7), GRB2(1), HRAS(16), JUN(4), LAT(1), LCK(2), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NFKB1(3), NFKBIA(6), PIK3CA(94), PIK3R1(6), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKCA(3), PTPN7(1), RAC1(4), RAF1(4), RASA1(8), RELA(6), SHC1(8), SOS1(23), SYT1(6), VAV1(8), ZAP70(2) 27835098 326 200 258 79 181 15 63 35 32 0 0.0837 1.000 1.000 205 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(5), CALM1(2), CALM2(2), ELK1(1), FCER1A(5), FCER1G(1), FOS(4), GRB2(1), HRAS(16), JUN(4), LYN(5), MAP2K1(3), MAP2K4(4), MAP2K7(3), MAP3K1(10), MAPK3(8), MAPK8(5), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), PAK2(9), PIK3CA(94), PIK3R1(6), PLA2G4A(1), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), RAF1(4), SHC1(8), SOS1(23), SYK(8), SYT1(6), VAV1(8) 25068407 316 199 248 66 172 15 58 40 31 0 0.0107 1.000 1.000 206 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(29), AR(5), ASAH1(4), BRAF(9), CAMP(1), CCL13(2), CCL15(1), CCL16(1), DAG1(3), EGFR(7), GNA11(3), GNA15(5), GNAI1(4), GNAQ(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), MAPK10(9), MAPK14(2), PHKA2(8), PIK3CA(94), PIK3CD(7), PIK3R1(6), PITX2(5), PTX3(6), RAF1(4), SRC(5) 30973378 307 195 245 89 182 11 42 40 32 0 0.240 1.000 1.000 207 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(11), EGF(17), EGFR(7), ELK1(1), FOS(4), GRB2(1), HRAS(16), JAK1(9), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), PIK3CA(94), PIK3R1(6), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4), STAT1(13), STAT3(6), STAT5A(1) 21866273 282 192 213 53 159 10 52 31 30 0 0.00152 1.000 1.000 208 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(4), ACADL(2), ACADM(1), ACOX1(6), ACOX2(9), ACOX3(7), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(5), ACSL6(1), ADIPOQ(2), ANGPTL4(6), APOA1(2), APOA2(4), APOA5(4), APOC3(1), AQP7(7), CD36(2), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), CYP27A1(9), CYP4A11(5), CYP4A22(7), CYP7A1(10), CYP8B1(5), DBI(2), EHHADH(6), FABP1(2), FABP2(1), FABP5(1), FABP6(1), FADS2(2), GK(2), GK2(6), HMGCS2(7), ILK(3), LPL(4), ME1(5), MMP1(3), NR1H3(3), PCK1(9), PCK2(2), PDPK1(2), PLTP(6), PPARA(1), PPARD(6), PPARG(13), RXRA(25), RXRB(3), RXRG(8), SCD(2), SCP2(4), SLC27A1(6), SLC27A2(10), SLC27A4(2), SLC27A5(9), SLC27A6(6), SORBS1(10), UBC(9), UCP1(4) 37986717 317 191 295 109 156 16 77 24 44 0 0.626 1.000 1.000 209 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), HRAS(16), JAK1(9), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), PDGFRA(16), PIK3CA(94), PIK3R1(6), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4), STAT1(13), STAT3(6), STAT5A(1) 20366460 274 191 205 51 152 9 51 31 31 0 0.00102 1.000 1.000 210 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CFLAR(2), DAXX(9), DFFA(6), FADD(7), FAF1(4), JUN(4), LMNA(5), LMNB1(4), LMNB2(7), MAP2K4(4), MAP3K1(10), MAP3K7(8), MAPK8(5), PAK1(4), PAK2(9), PRKDC(35), PTPN13(19), RB1(73), RIPK2(5), SPTAN1(68) 23432912 313 188 302 71 129 9 32 15 121 7 0.334 1.000 1.000 211 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(4), CASP2(2), CASP3(3), CASP8(14), CRADD(1), DFFA(6), FADD(7), JUN(4), LMNA(5), LMNB1(4), LMNB2(7), MADD(11), MAP2K4(4), MAP3K1(10), MAP3K7(8), MAPK8(5), PAK1(4), PAK2(9), PRKDC(35), RB1(73), RIPK1(7), SPTAN1(68), TNF(4), TNFRSF1A(5), TRADD(2), TRAF2(5) 22382147 308 186 296 61 132 11 26 15 118 6 0.0301 1.000 1.000 212 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(23), CARM1(6), CCND1(4), CREBBP(50), EP300(77), ERCC3(7), ESR1(5), GRIP1(12), GTF2A1(3), GTF2E1(7), GTF2F1(5), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(6), HDAC6(12), MEF2C(5), NCOR2(19), NR0B1(4), NRIP1(7), PELP1(5), POLR2A(13), TBP(2) 26423386 282 184 271 71 120 11 51 29 69 2 0.156 1.000 1.000 213 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(4), AKT3(6), BAD(2), BCR(3), BLNK(8), BTK(5), CD19(4), CSK(7), DAG1(3), EPHB2(10), GRB2(1), ITPKA(4), ITPKB(5), LYN(5), MAP2K1(3), MAP2K2(5), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PI3(1), PIK3CA(94), PIK3CD(7), PIK3R1(6), PLCG2(6), PPP1R13B(7), RAF1(4), SERPINA4(2), SHC1(8), SOS1(23), SOS2(8), SYK(8), VAV1(8) 30626932 300 184 239 74 174 9 51 39 27 0 0.0600 1.000 1.000 214 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(29), AXIN1(4), CCND1(4), CCND2(1), CCND3(5), CSNK1E(3), CTNNB1(15), DVL1(5), DVL2(9), DVL3(4), FBXW2(5), FOSL1(3), FZD1(4), FZD10(9), FZD2(3), FZD3(6), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GSK3B(4), JUN(4), LDLR(10), MAPK10(9), MAPK9(5), MYC(2), PAFAH1B1(2), PPP2R5C(6), PPP2R5E(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PRKD1(12), RAC1(4), RHOA(19), SFRP4(5), TCF7(1), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1) 34801725 307 183 294 105 167 17 54 25 44 0 0.640 1.000 1.000 215 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(14), ADAM17(7), ATP6AP1(3), ATP6V0A1(12), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), CASP3(3), CCL5(1), CDC42(4), CHUK(7), CSK(7), CXCL1(1), EGFR(7), F11R(5), GIT1(6), HBEGF(1), IGSF5(4), IKBKB(11), JAM2(1), JAM3(4), JUN(4), LYN(5), MAP2K4(4), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK8(5), MAPK9(5), MET(19), NFKB1(3), NFKB2(3), NFKBIA(6), NOD1(6), PAK1(4), PLCG1(12), PLCG2(6), PTPN11(4), PTPRZ1(20), RAC1(4), RELA(6), SRC(5), TCIRG1(6), TJP1(9) 40872207 324 182 319 86 171 13 68 26 46 0 0.108 1.000 1.000 216 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A1(4), EIF4A2(11), EIF4B(4), EIF4E(2), EIF4EBP1(1), EIF4G1(17), EIF4G2(10), EIF4G3(27), FKBP1A(1), MKNK1(6), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(6), PPP2CA(2), PTEN(16), RPS6(5), RPS6KB1(4), TSC1(34), TSC2(11) 16056976 262 181 197 45 132 10 38 26 55 1 0.00538 1.000 1.000 217 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(9), CPEB1(7), EGFR(7), ERBB2(54), ERBB4(11), ETS1(5), ETS2(5), ETV6(12), ETV7(4), FMN2(26), GRB2(1), KRAS(13), MAP2K1(3), MAPK3(8), NOTCH1(17), NOTCH2(11), NOTCH3(12), NOTCH4(14), PIWIL1(12), PIWIL2(8), PIWIL3(6), PIWIL4(8), RAF1(4), SOS1(23), SOS2(8), SPIRE1(2), SPIRE2(9) 30169663 299 179 257 86 145 18 68 32 34 2 0.491 1.000 1.000 218 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BAD(2), BCL2L1(4), CBL(8), CFLAR(2), CRKL(1), E2F1(3), FOS(4), GRB2(1), HRAS(16), IL2RA(1), IL2RB(2), IL2RG(5), IRS1(9), JAK1(9), JAK3(12), MAPK3(8), MYC(2), NMI(4), PIK3CA(94), PIK3R1(6), PPIA(1), PTPN6(2), RAF1(4), RPS6KB1(4), SHC1(8), SOCS3(1), SOS1(23), STAT5A(1), STAT5B(5), SYK(8) 20983934 253 179 186 69 134 10 47 31 30 1 0.195 1.000 1.000 219 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), DAG1(3), DGKA(9), GCA(1), ITGA9(9), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), MAP2K1(3), MAPK3(8), NR1I3(4), PAK1(4), PDE3A(11), PDE3B(9), PI3(1), PIK3C2G(11), PIK3CA(94), PIK3CD(7), PIK3R1(6), PSME1(2), RIPK3(6), RPS4X(4), SGCB(1), VASP(1) 28205598 277 179 215 84 163 14 40 29 31 0 0.362 1.000 1.000 220 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(4), AKT1(3), AKT2(4), AKT3(6), BAD(2), BTK(5), CDKN2A(30), DAPP1(2), GRB2(1), GSK3A(2), GSK3B(4), IARS(6), IGFBP1(4), INPP5D(5), PDK1(2), PIK3CA(94), PPP1R13B(7), PTEN(16), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(8), SOS1(23), SOS2(8), TEC(10), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 20890972 294 179 225 46 172 13 33 32 42 2 0.000193 1.000 1.000 221 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(4), ALG6(3), CCKBR(8), CCR3(3), CCR5(6), CELSR1(20), CELSR2(18), CELSR3(29), CHRM2(5), CHRM3(8), CIDEB(2), CXCR3(3), DRD4(1), EDNRA(4), EMR2(6), EMR3(4), F2R(2), FSHR(5), GHRHR(3), GNRHR(2), GPR116(10), GPR132(4), GPR133(12), GPR135(2), GPR143(1), GPR17(3), GPR18(3), GPR55(2), GPR56(7), GPR61(7), GPR84(2), GPR88(3), GRM1(22), GRPR(1), HRH4(3), LGR6(8), LPHN2(21), LPHN3(21), LTB4R2(3), NTSR1(2), OR2M4(3), P2RY11(1), P2RY13(3), PTGFR(7), SMO(8), TAAR5(2), TSHR(8), VN1R1(1) 38569589 306 178 299 142 126 15 86 40 38 1 0.909 1.000 1.000 222 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(9), EIF1(1), EIF2B1(1), EIF2B2(5), EIF2B3(1), EIF2B4(10), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), ELAVL1(7), FLT1(8), FLT4(10), HIF1A(6), HRAS(16), KDR(19), NOS3(11), PIK3CA(94), PIK3R1(6), PLCG1(12), PRKCA(3), PTK2(12), PXN(3), SHC1(8), VHL(2) 19756305 267 178 201 55 153 11 43 29 31 0 0.00370 1.000 1.000 223 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CDK5(3), CDK5R1(5), CFL1(1), CHN1(3), LIMK1(6), MAP3K1(10), MYL2(4), MYLK(15), NCF2(6), PAK1(4), PDGFRA(16), PIK3CA(94), PIK3R1(6), PLD1(9), PPP1R12B(10), RAC1(4), RALBP1(2), RPS6KB1(4), TRIO(36), VAV1(8), WASF1(5) 20347679 253 177 193 63 149 9 35 28 31 1 0.140 1.000 1.000 224 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(11), FOS(4), GRB2(1), HRAS(16), JAK2(8), JUN(4), MAP2K1(3), MAPK3(8), MPL(7), PIK3CA(94), PIK3R1(6), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), STAT1(13), STAT3(6), STAT5A(1), STAT5B(5), THPO(4) 17521128 249 177 180 47 150 10 36 27 26 0 0.00383 1.000 1.000 225 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(9), ACTB(20), ACTG1(11), ARHGEF2(7), ARPC5(5), CD14(3), CDC42(4), CDH1(15), CLDN1(3), CTNNB1(15), CTTN(9), EZR(12), FYN(7), HCLS1(5), ITGB1(3), KRT18(5), LY96(1), NCK1(2), NCK2(5), NCL(3), OCLN(4), PRKCA(3), RHOA(19), ROCK1(8), ROCK2(15), TLR4(6), TLR5(11), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(3), WAS(4), WASL(2), YWHAQ(3), YWHAZ(6) 30660327 285 176 272 82 153 12 59 25 35 1 0.398 1.000 1.000 226 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(9), ACTB(20), ACTG1(11), ARHGEF2(7), ARPC5(5), CD14(3), CDC42(4), CDH1(15), CLDN1(3), CTNNB1(15), CTTN(9), EZR(12), FYN(7), HCLS1(5), ITGB1(3), KRT18(5), LY96(1), NCK1(2), NCK2(5), NCL(3), OCLN(4), PRKCA(3), RHOA(19), ROCK1(8), ROCK2(15), TLR4(6), TLR5(11), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(3), WAS(4), WASL(2), YWHAQ(3), YWHAZ(6) 30660327 285 176 272 82 153 12 59 25 35 1 0.398 1.000 1.000 227 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(15), CANT1(1), CDA(1), CTPS2(3), DCK(4), DCTD(2), DHODH(2), DPYD(14), DPYS(13), DUT(2), ENTPD1(1), ENTPD3(5), ENTPD5(4), ENTPD6(2), ENTPD8(5), ITPA(1), NME1(1), NME2(1), NME4(1), NME6(1), NME7(3), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), PNPT1(10), POLA1(8), POLA2(11), POLD1(8), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLR1A(18), POLR1B(4), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2), PRIM2(1), RFC5(5), RRM1(4), RRM2(3), RRM2B(2), TK1(2), TXNRD1(6), TXNRD2(1), TYMS(3), UCK1(2), UMPS(4), UPB1(4), UPP2(3), UPRT(5) 47018508 314 174 312 129 168 19 50 36 40 1 0.995 1.000 1.000 228 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPPL1(11), ITPKA(4), ITPKB(5), OCRL(4), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3CA(94), PIK3CB(11), PIK3CG(10), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLCD1(5), PLCG1(12), PLCG2(6) 25917403 271 174 210 79 161 9 42 31 28 0 0.301 1.000 1.000 229 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(4), AKT3(6), BAD(2), GRB2(1), GSK3A(2), GSK3B(4), IL4R(6), IRS1(9), IRS2(5), JAK1(9), JAK3(12), MAP4K1(8), MAPK3(8), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3R1(6), PPP1R13B(7), RAF1(4), SHC1(8), SOS1(23), SOS2(8), STAT6(9) 21257169 247 174 187 58 143 7 38 34 25 0 0.0521 1.000 1.000 230 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(5), ALPL(4), ALPP(3), ASCC3(22), ATP13A2(15), DDX18(11), DDX19A(4), DDX23(13), DDX4(12), DDX41(2), DDX47(2), DDX50(5), DDX51(2), DDX52(8), DDX54(9), DDX55(4), DHX58(3), ENTPD7(5), EP400(23), ERCC2(38), ERCC3(7), FPGS(4), GCH1(1), GGH(3), IFIH1(8), MOV10L1(7), NUDT5(3), QDPR(3), RAD54B(5), RAD54L(9), RUVBL2(2), SETX(27), SKIV2L2(9), SMARCA2(23), SMARCA5(4) 36425321 305 171 286 98 149 13 65 49 29 0 0.720 1.000 1.000 231 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(12), DIAPH1(5), FYN(7), GSN(2), HRAS(16), ITGA1(7), ITGB1(3), MAP2K1(3), MAPK3(8), MYL2(4), MYLK(15), PFN1(4), PIK3CA(94), PIK3R1(6), PTK2(12), PXN(3), RAF1(4), ROCK1(8), SHC1(8), SRC(5), TLN1(17) 21777703 243 169 178 43 135 8 47 33 20 0 0.00166 1.000 1.000 232 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(3), GHR(6), GRB2(1), HRAS(16), INSR(10), IRS1(9), JAK2(8), MAP2K1(3), MAPK3(8), PIK3CA(94), PIK3R1(6), PLCG1(12), PRKCA(3), PTPN6(2), RAF1(4), RPS6KA1(5), SHC1(8), SLC2A4(4), SOS1(23), SRF(4), STAT5A(1), STAT5B(5) 19321316 235 169 169 60 139 6 42 29 19 0 0.0699 1.000 1.000 233 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), HRAS(16), INSR(10), IRS1(9), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PIK3CA(94), PIK3R1(6), PTPN11(4), RAF1(4), RASA1(8), SHC1(8), SLC2A4(4), SOS1(23), SRF(4) 14807904 227 169 159 44 137 6 37 31 16 0 0.00408 1.000 1.000 234 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(4), AANAT(2), ACAT1(5), ACAT2(1), ACMSD(2), AFMID(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), AOX1(8), ASMT(1), CARM1(6), CAT(9), CYP1A1(2), CYP1A2(4), CYP1B1(3), DDC(8), ECHS1(1), EHHADH(6), GCDH(5), HAAO(1), HADH(5), HADHA(4), HEMK1(1), HSD17B10(1), HSD17B4(5), INMT(1), KMO(1), KYNU(1), LCMT1(2), LCMT2(12), LNX1(4), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), NFX1(8), OGDH(21), OGDHL(10), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), TDO2(3), TPH1(3), TPH2(4), WARS(5), WARS2(2), WBSCR22(6) 35180634 243 167 235 76 127 10 45 24 37 0 0.411 1.000 1.000 235 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(29), AXIN1(4), CREBBP(50), CTNNB1(15), DVL1(5), EP300(77), FZD1(4), GSK3B(4), HDAC1(4), LDB1(3), LEF1(4), PITX2(5), TRRAP(40) 19295421 244 167 230 41 99 10 43 23 67 2 0.000758 1.000 1.000 236 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A1(4), EIF4A2(11), EIF4E(2), EIF4EBP1(1), EIF4G1(17), EIF4G2(10), EIF4G3(27), GHR(6), IRS1(9), MAPK14(2), MAPK3(8), MKNK1(6), PABPC1(7), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(6), PRKCA(3), PTEN(16), RPS6KB1(4) 16448621 240 166 179 48 134 10 35 29 31 1 0.0570 1.000 1.000 237 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(6), AKT1(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), GNAS(12), GRB2(1), HRAS(16), MAPK14(2), MAPK3(8), PIK3CA(94), PIK3R1(6), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), RAC1(4), RPS6KA1(5), RPS6KA5(9), SOS1(23) 16966243 231 165 165 54 141 6 41 28 15 0 0.0498 1.000 1.000 238 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(18), ATP4A(5), ATP4B(2), ATP5A1(7), ATP5B(5), ATP5C1(4), ATP5E(1), ATP5F1(4), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5I(1), ATP5J(1), ATP5J2(2), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), COX10(4), COX15(4), COX17(2), COX4I2(1), COX5A(5), COX6A1(5), COX6C(2), COX7A1(1), COX7A2(1), COX7B(1), COX7B2(3), COX8A(1), CYC1(7), LHPP(2), NDUFA1(1), NDUFA10(4), NDUFA12(1), NDUFA13(1), NDUFA5(1), NDUFA6(2), NDUFA7(2), NDUFA8(4), NDUFA9(4), NDUFAB1(2), NDUFB10(2), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFB9(3), NDUFS1(5), NDUFS2(3), NDUFS3(1), NDUFS4(3), NDUFS6(1), NDUFS7(3), NDUFS8(1), NDUFV1(4), NDUFV2(6), PPA1(1), PPA2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(3), TCIRG1(6), UQCRB(1), UQCRC1(2), UQCRC2(4), UQCRFS1(3), UQCRH(2) 32357592 279 164 273 87 140 12 57 30 40 0 0.399 1.000 1.000 239 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(6), AKT1(3), ASAH1(4), GNAI1(4), GNB1(7), ITGAV(13), ITGB3(9), MAPK3(8), PDGFRA(16), PIK3CA(94), PIK3R1(6), PLCB1(16), PRKCA(3), PTK2(12), RAC1(4), SMPD1(4), SMPD2(2), SPHK1(1), SRC(5) 15998412 217 162 157 40 126 11 34 29 17 0 0.000689 1.000 1.000 240 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCR(3), CRKL(1), FOS(4), GRB2(1), HRAS(16), JAK2(8), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), MYC(2), PIK3CA(94), PIK3R1(6), RAF1(4), SOS1(23), STAT1(13), STAT5A(1), STAT5B(5) 16384918 218 162 149 46 130 7 32 25 24 0 0.0309 1.000 1.000 241 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(10), CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), HDAC5(6), IGF1(2), IGF1R(11), INSR(10), MAP2K6(1), MAPK14(2), MAPK7(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MYOD1(1), NFATC1(13), NFATC2(13), PIK3CA(94), PIK3R1(6), PPP3CA(7), PPP3CB(6), PPP3CC(4), SYT1(6), YWHAH(2) 20104042 231 162 172 58 132 14 35 26 24 0 0.0467 1.000 1.000 242 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(45), B3GALT4(6), CDR1(4), DGKI(9), IL6ST(9), MRPL19(2), PIGK(4), RPL10(3), RPL11(2), RPL13(3), RPL15(3), RPL17(4), RPL19(2), RPL23(4), RPL24(3), RPL26(4), RPL28(2), RPL29(2), RPL3(1), RPL30(1), RPL31(5), RPL34(2), RPL35A(1), RPL36(1), RPL37(1), RPL3L(3), RPL4(5), RPL41(1), RPL5(3), RPL6(2), RPL7(3), RPL8(2), RPL9(1), RPLP0(3), RPLP2(1), RPS10(1), RPS12(3), RPS13(2), RPS15(1), RPS16(1), RPS18(6), RPS19(1), RPS2(6), RPS20(2), RPS24(1), RPS26(1), RPS27A(1), RPS29(1), RPS3A(1), RPS4X(4), RPS4Y1(1), RPS5(1), RPS6(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA6(11), RPS6KB1(4), RPS6KB2(1), RPS7(2), RPS8(2), RPS9(2), RPSA(4), SLC36A2(1), TBC1D10C(5), TSPAN9(2), UBA52(7), UBC(9) 30355677 259 162 254 100 131 19 54 25 29 1 0.935 1.000 1.000 243 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(8), CD28(3), CSK(7), CTLA4(1), DAG1(3), EPHB2(10), FBXW7(35), GRAP2(3), GRB2(1), ITK(6), ITPKA(4), ITPKB(5), LAT(1), LCK(2), LCP2(5), NCK1(2), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PLCG1(12), PTPRC(19), RAF1(4), RASGRP1(6), RASGRP2(4), RASGRP3(5), RASGRP4(1), SOS1(23), SOS2(8), VAV1(8), ZAP70(2) 32312362 261 161 249 78 126 7 59 29 40 0 0.556 1.000 1.000 244 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1C1(2), AKR1C2(1), AKR1C3(3), AKR1C4(5), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), CYP1A1(2), CYP1A2(4), CYP1B1(3), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(3), CYP2E1(4), CYP2F1(4), CYP2S1(2), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), DHDH(3), EPHX1(5), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(3), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(4), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), MGST1(1), MGST2(1), MGST3(1), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2) 33419411 248 160 247 88 119 14 48 28 39 0 0.669 1.000 1.000 245 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(4), AKT3(6), CISH(1), GRB2(1), IARS(6), IL13RA1(2), IL2RG(5), IL4R(6), INPP5D(5), JAK1(9), JAK2(8), JAK3(12), NR0B2(2), PI3(1), PIK3CA(94), PPP1R13B(7), RPS6KB1(4), SERPINA4(2), SHC1(8), SOS1(23), SOS2(8), SRC(5), STAT6(9), TYK2(9) 21390961 240 160 180 54 144 7 35 31 22 1 0.0275 1.000 1.000 246 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(4), AKT3(6), ASAH1(4), BRAF(9), DAG1(3), DRD2(5), EGFR(7), EPHB2(10), GRB2(1), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), PI3(1), PIK3CB(11), PITX2(5), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), RAF1(4), RGS20(3), SHC1(8), SOS1(23), SOS2(8), SRC(5), STAT3(6), TERF2IP(4) 34007869 253 159 248 98 132 9 52 30 30 0 0.937 1.000 1.000 247 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(1), BMP5(6), BMP6(5), BMP7(4), BMP8B(3), BTRC(4), CSNK1A1(6), CSNK1A1L(4), CSNK1D(3), CSNK1E(3), CSNK1G1(6), CSNK1G2(6), CSNK1G3(3), FBXW11(1), GLI1(10), GLI2(16), GLI3(19), GSK3B(4), HHIP(9), IHH(3), LRP2(45), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(1), PTCH1(19), PTCH2(5), RAB23(2), SHH(6), SMO(8), STK36(11), SUFU(2), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(3), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2), ZIC2(7) 35144072 270 158 267 111 114 13 76 22 45 0 0.984 1.000 1.000 248 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(6), ADCY6(15), ADCY8(18), CACNA1A(25), CACNA1B(17), GNAS(12), GNAT3(2), GNB1(7), GNB3(5), GNG3(3), GRM4(9), ITPR3(9), KCNB1(8), PDE1A(8), PLCB2(6), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(1), SCNN1A(11), SCNN1B(6), SCNN1G(5), TAS1R1(2), TAS1R2(7), TAS1R3(20), TAS2R1(1), TAS2R13(2), TAS2R14(1), TAS2R16(4), TAS2R3(3), TAS2R39(3), TAS2R4(1), TAS2R40(2), TAS2R41(3), TAS2R43(1), TAS2R46(3), TAS2R5(1), TAS2R50(3), TAS2R60(5), TAS2R7(1), TAS2R8(1), TAS2R9(6), TRPM5(3) 32728290 252 155 239 121 139 15 57 22 19 0 0.886 1.000 1.000 249 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(19), AMY2A(3), AMY2B(9), ENPP1(7), ENPP3(5), G6PC(2), GAA(5), GANAB(16), GBE1(2), GCK(1), GPI(4), GUSB(3), GYS1(12), GYS2(13), HK1(15), HK2(11), HK3(8), MGAM(13), PGM1(3), PGM3(1), PYGB(8), PYGL(4), PYGM(13), RNPC3(1), SI(23), UCHL1(3), UCHL3(3), UGDH(5), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4), UXS1(3) 33041540 257 155 255 93 115 17 56 32 37 0 0.925 1.000 1.000 250 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(29), AXIN1(4), CCND1(4), CD14(3), CTNNB1(15), DVL1(5), FZD1(4), GJA1(3), GNAI1(4), GSK3B(4), IRAK1(3), LBP(2), LEF1(4), LY96(1), MYD88(1), NFKB1(3), PDPK1(2), PIK3CA(94), PIK3R1(6), PPP2CA(2), RELA(6), TLR4(6), TOLLIP(3) 17815899 211 153 147 41 132 6 27 20 26 0 0.0206 1.000 1.000 251 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(34), EEF1A2(3), EEF1B2(2), EEF1D(1), EEF1G(4), EEF2(5), EEF2K(7), EIF2AK1(5), EIF2AK2(7), EIF2AK3(12), EIF2B1(1), EIF2B2(5), EIF2B3(1), EIF2B4(10), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF4A1(4), EIF4A2(11), EIF4E(2), EIF4EBP1(1), EIF4EBP2(3), EIF4G1(17), EIF4G3(27), EIF5(9), EIF5A(5), EIF5B(11), ETF1(2), GSPT2(6), PABPC1(7), PABPC3(8), PAIP1(11), SLC35A4(3) 25401472 247 153 244 52 124 11 47 28 37 0 0.0807 1.000 1.000 252 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(7), DAXX(9), EGF(17), EGFR(7), ETS1(5), ETS2(5), FOS(4), HOXA7(5), HRAS(16), IKBKB(11), JUN(4), MAP2K1(3), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK13(3), MAPK14(2), MAPK3(8), MAPK8(5), NFKB1(3), NFKBIA(6), PPP2CA(2), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCQ(10), RAF1(4), RELA(6), RIPK1(7), SP1(10), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRAF2(5) 28517290 246 152 237 95 120 14 58 17 37 0 0.944 1.000 1.000 253 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(3), BDKRB2(2), CALM1(2), CALM2(2), CHRM1(2), CHRNA1(2), FLT1(8), FLT4(10), KDR(19), NOS3(11), PDE2A(2), PDE3A(11), PDE3B(9), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKG1(8), PRKG2(8), RYR2(83), SLC7A1(8), SYT1(6), TNNI1(5) 23210929 225 151 224 92 92 13 55 33 31 1 0.979 1.000 1.000 254 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(3), GORASP1(2), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MAPKAPK5(3), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PIK3CA(94), PIK3CD(7), PIK3R1(6), SYT1(6), TRAF2(5), TRAF3(2), TRAF5(1), TRAF6(1) 19379493 218 151 158 46 133 12 33 23 17 0 0.00483 1.000 1.000 255 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(8), CARM1(6), COMT(3), DBH(4), DCT(8), DDC(8), ECH1(7), ESCO1(3), ESCO2(3), FAH(3), GOT1(2), GSTZ1(2), HEMK1(1), HGD(4), HPD(4), LCMT1(2), LCMT2(12), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), MIF(1), NAT6(1), PNPLA3(4), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SH3GLB1(1), TAT(5), TH(2), TPO(16), TYR(12), TYRP1(2), WBSCR22(6) 34515087 223 149 219 63 104 7 57 24 31 0 0.203 1.000 1.000 256 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(5), AKR1D1(5), ARSD(7), ARSE(2), CARM1(6), CYP11B1(4), CYP11B2(13), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(1), HSD17B12(3), HSD17B2(6), HSD17B3(1), HSD17B7(3), HSD17B8(4), HSD3B1(5), HSD3B2(5), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SRD5A1(4), STS(5), SULT1E1(1), SULT2A1(4), SULT2B1(2), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), WBSCR22(6) 29200143 218 148 213 64 108 12 48 30 20 0 0.258 1.000 1.000 257 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(4), AASS(11), ACAT1(5), ACAT2(1), AKR1B10(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), BBOX1(4), DLST(1), DOT1L(21), ECHS1(1), EHHADH(6), EHMT1(8), EHMT2(12), GCDH(5), HADH(5), HADHA(4), HSD17B10(1), HSD17B4(5), HSD3B7(2), NSD1(23), OGDH(21), OGDHL(10), PIPOX(4), PLOD1(3), PLOD2(5), PLOD3(5), RDH12(2), RDH13(1), SETD1A(9), SETD7(3), SETDB1(14), SHMT1(3), SHMT2(2), SPCS3(1), SUV39H2(1), TMLHE(2) 33573987 228 147 222 115 128 9 40 19 32 0 1.000 1.000 1.000 258 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AGK(1), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), AKR1A1(2), AKR1B1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), CEL(8), DAK(4), DGAT1(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), GK(2), GK2(6), GLA(3), GLB1(5), GPAM(5), LCT(16), LIPA(3), LIPC(6), LIPF(6), LIPG(4), LPL(4), MGLL(2), PNLIP(5), PNLIPRP1(8), PNPLA3(4), PPAP2A(5), PPAP2B(3), PPAP2C(1) 33796651 252 147 250 89 120 14 53 25 40 0 0.618 1.000 1.000 259 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(6), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), CDIPT(2), CDS1(5), CDS2(3), CHAT(4), CHKA(5), CHKB(4), CHPT1(6), CRLS1(1), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), ESCO1(3), ESCO2(3), ETNK1(4), ETNK2(1), GNPAT(4), GPAM(5), GPD1(6), GPD1L(3), GPD2(9), LCAT(3), LYPLA1(2), LYPLA2(2), NAT6(1), PCYT1A(1), PCYT1B(2), PEMT(1), PISD(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLD1(9), PLD2(3), PNPLA3(4), PPAP2A(5), PPAP2B(3), PPAP2C(1), PTDSS1(7), PTDSS2(1), SH3GLB1(1) 37665706 243 146 242 91 116 15 50 24 38 0 0.916 1.000 1.000 260 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(12), AR(5), ESR1(5), ESR2(3), ESRRA(2), HNF4A(5), NPM1(1), NR0B1(4), NR1D1(3), NR1D2(10), NR1H2(6), NR1H3(3), NR1I2(5), NR1I3(4), NR2C2(6), NR2E1(1), NR2F1(3), NR2F2(5), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(4), NR5A1(1), NR5A2(6), PGR(8), PPARA(1), PPARD(6), PPARG(13), RARA(4), RARB(7), RARG(21), ROR1(6), RORA(4), RORC(6), RXRA(25), RXRB(3), RXRG(8), THRA(2), THRB(1), VDR(2) 24214692 220 146 201 79 114 12 46 19 29 0 0.725 1.000 1.000 261 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(3), AGTR2(4), ATP8A1(11), AVPR1A(4), AVPR1B(3), AVPR2(3), BDKRB1(4), BDKRB2(2), BRS3(4), C3AR1(4), CCKAR(3), CCKBR(8), CCR1(1), CCR10(3), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(4), CX3CR1(4), CXCR3(3), CXCR4(4), CXCR6(4), EDNRA(4), EDNRB(8), FPR1(3), FSHR(5), GALR1(3), GALR2(4), GALR3(3), GALT(1), GHSR(6), GNB2L1(3), GNRHR(2), GRPR(1), LHCGR(7), MC1R(2), MC3R(4), MC4R(3), MC5R(3), NMBR(6), NPY1R(7), NPY2R(4), NPY5R(5), NTSR1(2), NTSR2(2), OPRD1(5), OPRK1(4), OPRL1(2), OXTR(1), SSTR1(3), SSTR3(4), SSTR4(6), TAC4(1), TACR1(3), TACR2(1), TACR3(5), TRHR(9), TSHR(8) 30531920 233 146 232 129 96 6 69 35 27 0 0.986 1.000 1.000 262 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ACAT1(5), ACAT2(1), ACMSD(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), AOC2(5), AOC3(6), AOX1(8), ASMT(1), CAT(9), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(3), CYP2D6(5), CYP2E1(4), CYP2F1(4), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(9), CYP4B1(5), CYP51A1(4), DDC(8), ECHS1(1), EHHADH(6), GCDH(5), HAAO(1), HADHA(4), KMO(1), KYNU(1), MAOA(4), MAOB(2), SDS(2), TDO2(3), TPH1(3), WARS(5), WARS2(2) 32067281 224 146 221 84 110 10 46 25 33 0 0.731 1.000 1.000 263 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(9), CDC7(4), CDK2(1), CDT1(2), DIAPH2(21), GMNN(1), MCM10(15), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), NACA(14), PCNA(4), POLA2(11), POLD1(8), POLD2(3), POLD3(5), POLE(27), POLE2(4), RFC1(9), RFC2(5), RFC3(1), RFC4(10), RFC5(5), RPA2(1), RPA3(4), RPA4(1), RPS27A(1), UBA52(7), UBC(9) 29496490 218 145 209 62 127 10 33 21 26 1 0.357 1.000 1.000 264 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(17), ANAPC2(12), ANAPC4(8), ANAPC5(12), ANAPC7(6), BTRC(4), CDC16(4), CDC20(4), CDC23(1), CDC27(12), CUL1(19), CUL2(13), CUL3(9), FBXW11(1), FBXW7(35), FZR1(5), ITCH(12), RBX1(1), SKP1(6), SKP2(5), SMURF1(8), SMURF2(8), TCEB1(1), UBA1(1), UBE2C(3), UBE2D1(2), UBE2D2(1), UBE2D3(3), UBE2D4(1), UBE2E2(1), UBE2E3(1), VHL(2), WWP1(5), WWP2(5) 23333351 228 145 210 41 112 7 47 18 43 1 0.0200 1.000 1.000 265 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(7), CREBBP(50), DUSP1(3), EP300(77), IKBKB(11), IL1B(3), MAP2K3(6), MAP2K6(1), MAP3K7(8), MAPK11(5), MAPK14(2), MYD88(1), NFKB1(3), NFKBIA(6), NR3C1(6), RELA(6), TGFBR1(7), TGFBR2(8), TLR2(3), TNF(4) 17198705 217 145 209 43 82 9 31 19 73 3 0.0392 1.000 1.000 266 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(29), AXIN1(4), BTRC(4), CCND1(4), CREBBP(50), CSNK1A1(6), CSNK1D(3), CSNK2A1(11), CTBP1(4), CTNNB1(15), DVL1(5), FZD1(4), GSK3B(4), HDAC1(4), MAP3K7(8), MYC(2), NLK(6), PPARD(6), PPP2CA(2), TLE1(6), WIF1(6) 16992324 183 144 175 48 84 7 31 17 43 1 0.466 1.000 1.000 267 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(8), BTK(5), CALM1(2), CALM2(2), CD79A(4), CD79B(2), ELK1(1), FOS(4), GRB2(1), HRAS(16), JUN(4), LYN(5), MAP2K1(3), MAP3K1(10), MAPK14(2), MAPK3(8), MAPK8(5), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKCA(3), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SYK(8), SYT1(6), VAV1(8) 22254545 216 143 207 62 98 11 52 25 30 0 0.496 1.000 1.000 268 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(7), ACSS2(2), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH3B1(4), ALDH3B2(5), ALDH7A1(1), ALDH9A1(7), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), G6PC2(2), GALM(2), GAPDH(3), GAPDHS(2), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(1), PFKL(1), PFKM(5), PFKP(4), PGAM1(1), PGAM2(4), PGAM4(4), PGK1(2), PGM1(3), PGM3(1), PKLR(8), TPI1(1) 33826358 212 143 210 96 98 11 49 21 33 0 0.982 1.000 1.000 269 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(6), ARHGEF1(8), F2(3), F2R(2), F2RL3(2), GNA12(3), GNA13(12), GNAI1(4), GNAQ(3), GNB1(7), MAP3K7(8), PIK3CA(94), PIK3R1(6), PLCB1(16), PPP1R12B(10), PRKCA(3), PTK2B(6), ROCK1(8) 15005558 201 143 135 38 130 8 22 26 15 0 0.00363 1.000 1.000 270 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(3), AKT1(3), APC(29), ASAH1(4), CAMP(1), CAV3(1), DAG1(3), DLG4(4), EPHB2(10), GNAI1(4), GNAQ(3), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), PITX2(5), PTX3(6), RAC1(4), RHO(3), RYR1(54) 26624248 209 142 205 77 110 9 39 18 33 0 0.722 1.000 1.000 271 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), F10(5), F11(10), F12(3), F2(3), F2R(2), F5(24), F8(22), F9(3), FGA(17), FGB(5), FGG(7), KLKB1(2), PROC(2), PROS1(14), SERPINC1(7), SERPING1(3) 25660356 194 140 191 62 100 11 45 19 19 0 0.961 1.000 1.000 272 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(65), BMPR1B(4), CCND2(1), CDK4(5), CDKN1B(6), CEBPB(3), DAZL(3), DMC1(2), EGR1(7), ESR2(3), FSHR(5), GJA4(2), INHA(3), LHCGR(7), MLH1(9), MSH5(5), NCOR1(41), NR5A1(1), NRIP1(7), PGR(8), PRLR(4), PTGER2(7), SMPD1(4), VDR(2), ZP2(8) 20364106 212 140 209 58 88 8 42 26 47 1 0.499 1.000 1.000 273 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(7), BAD(2), BAX(1), BCL2A1(1), BCL2L1(4), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CD40(3), CD40LG(2), CRADD(1), CYCS(1), DAXX(9), DFFA(6), FADD(7), FAS(1), FASLG(1), IKBKE(6), LTA(1), MCL1(2), NFKB1(3), NFKBIA(6), NGFR(4), NR3C1(6), NTRK1(6), PTPN13(19), RIPK1(7), TFG(11), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5), TRAF3(2), TRAF6(1) 25113586 188 138 183 68 107 6 34 11 30 0 0.947 1.000 1.000 274 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), ELK1(1), FPR1(3), GNA15(5), GNB1(7), HRAS(16), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAPK14(2), MAPK3(8), NCF1(1), NCF2(6), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NFKB1(3), NFKBIA(6), PAK1(4), PIK3C2G(11), PLCB1(16), PPP3CA(7), PPP3CB(6), PPP3CC(4), RAC1(4), RAF1(4), RELA(6), SYT1(6) 22140035 205 137 198 63 94 14 49 21 27 0 0.655 1.000 1.000 275 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(6), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPS(5), CDIPT(2), CDS1(5), CDS2(3), CHAT(4), CHKA(5), CHKB(4), CLC(2), CPT1B(4), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), ETNK1(4), GNPAT(4), GPD1(6), GPD2(9), LCAT(3), LGALS13(3), LYPLA1(2), LYPLA2(2), PAFAH1B1(2), PAFAH2(4), PCYT1A(1), PCYT1B(2), PEMT(1), PISD(3), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB2(6), PLCG1(12), PLCG2(6), PPAP2A(5), PPAP2B(3), PPAP2C(1) 28674293 224 137 223 80 107 10 47 20 40 0 0.623 1.000 1.000 276 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(15), CANT1(1), CDA(1), CTPS2(3), DCK(4), DCTD(2), DHODH(2), DPYD(14), DPYS(13), DUT(2), ENTPD1(1), ITPA(1), NME1(1), NME2(1), NT5C(1), NT5E(6), POLD1(8), POLD2(3), POLE(27), POLG(8), POLQ(28), POLR1B(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5), RRM1(4), RRM2(3), TK1(2), TXNRD1(6), TYMS(3), UCK1(2), UMPS(4), UNG(1), UPB1(4) 33291369 217 137 217 98 109 12 34 30 31 1 0.998 1.000 1.000 277 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(4), CALM1(2), CALM2(2), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CDK5(3), F2(3), FYN(7), GNA11(3), GNAI1(4), GNB1(7), GRB2(1), HRAS(16), JAK2(8), MAP2K1(3), MAP2K2(5), MAPK14(2), MAPK3(8), MAPK8(5), MAPT(10), MYLK(15), PLCG1(12), PRKCA(3), PTK2B(6), RAF1(4), SHC1(8), SOS1(23), STAT1(13), STAT3(6), STAT5A(1), SYT1(6) 24219076 212 136 203 86 103 10 47 24 28 0 0.976 1.000 1.000 278 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AKR1A1(2), AKR1B1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), CEL(8), DGAT1(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), GK(2), GLA(3), GLB1(5), LCT(16), LIPC(6), LIPF(6), LIPG(4), LPL(4), PNLIP(5), PNLIPRP1(8), PPAP2A(5), PPAP2B(3), PPAP2C(1) 27691993 224 136 221 76 108 9 47 23 37 0 0.500 1.000 1.000 279 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(11), ACTG2(2), ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), CDC42(4), CFL1(1), CFL2(4), FLNA(14), FLNC(18), FSCN1(5), FSCN2(3), FSCN3(3), GDI1(3), GDI2(5), LIMK1(6), MYH2(22), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PFN1(4), PFN2(1), RHO(3), ROCK1(8), ROCK2(15), RPS4X(4), VASP(1), WASF1(5), WASL(2) 27858435 210 136 208 70 96 8 53 25 28 0 0.593 1.000 1.000 280 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(4), AKT3(6), ANKRD6(4), APC(29), AXIN1(4), AXIN2(19), CER1(4), CSNK1A1(6), CTNNB1(15), DACT1(6), DKK1(2), DKK2(5), DKK3(5), DKK4(2), DVL1(5), FSTL1(4), GSK3A(2), GSK3B(4), LRP1(36), MVP(11), NKD1(3), NKD2(1), PSEN1(8), PTPRA(2), SENP2(1), SFRP1(2), WIF1(6) 23332724 199 136 194 48 104 6 41 16 31 1 0.0903 1.000 1.000 281 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(1), PFKM(5), PFKP(4), PGAM1(1), PGK1(2), PGM1(3), PGM3(1), PKLR(8), TPI1(1) 28427706 194 135 191 78 88 9 47 19 31 0 0.900 1.000 1.000 282 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(1), PFKM(5), PFKP(4), PGAM1(1), PGK1(2), PGM1(3), PGM3(1), PKLR(8), TPI1(1) 28427706 194 135 191 78 88 9 47 19 31 0 0.900 1.000 1.000 283 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(27), ACACB(20), ACAT1(5), ACAT2(1), ACOT12(6), ACSS1(7), ACSS2(2), AKR1B1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), DLAT(6), DLD(7), GLO1(2), GRHPR(2), HAGH(2), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), LDHD(3), MDH1(3), ME1(5), ME2(1), ME3(6), PC(10), PCK1(9), PCK2(2), PDHA1(5), PDHA2(6), PDHB(1), PKLR(8) 27167995 180 134 177 67 94 6 38 18 24 0 0.825 1.000 1.000 284 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(3), B3GALT4(6), B3GALT5(3), B3GNT1(3), B3GNT2(5), B3GNT3(1), B3GNT4(3), B3GNT5(8), B4GALNT1(2), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), B4GALT6(2), FUT1(3), FUT2(6), FUT3(3), FUT4(3), FUT5(5), FUT6(2), FUT7(3), FUT9(3), GCNT2(2), PIGA(3), PIGB(5), PIGC(4), PIGF(2), PIGG(7), PIGK(4), PIGL(2), PIGM(2), PIGN(1), PIGO(11), PIGQ(5), PIGS(9), PIGT(2), PIGU(5), PIGV(5), PIGZ(3), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1), ST3GAL5(5), ST3GAL6(6), ST6GALNAC3(5), ST6GALNAC4(2), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(2), UGCG(3) 28060482 191 132 188 81 95 3 46 25 22 0 0.813 1.000 1.000 285 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(7), ACTN2(10), BCAR1(6), BCR(3), CAPN1(5), CAPNS2(1), CRKL(1), CSK(7), FYN(7), GRB2(1), HRAS(16), ITGA1(7), ITGB1(3), JUN(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MAPK8(5), PPP1R12B(10), PTK2(12), PXN(3), RAF1(4), RAP1A(1), ROCK1(8), SHC1(8), SOS1(23), SRC(5), TLN1(17), VCL(4), ZYX(4) 27325846 202 131 193 64 98 9 52 20 23 0 0.618 1.000 1.000 286 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(5), ALG10B(6), ALG11(5), ALG12(3), ALG13(4), ALG14(1), ALG2(2), ALG3(1), ALG5(3), ALG6(3), ALG8(2), ALG9(2), B4GALT1(4), B4GALT2(1), B4GALT3(5), DDOST(1), DHDDS(7), DOLPP1(1), DPAGT1(6), DPM1(3), FUT8(7), GANAB(16), MAN1A1(3), MAN1A2(6), MAN1B1(9), MAN1C1(6), MAN2A1(13), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(4), MGAT5(7), MGAT5B(7), RFT1(2), RPN1(3), RPN2(5), ST6GAL1(4), STT3B(5) 24433056 185 130 184 67 92 9 32 30 22 0 0.766 1.000 1.000 287 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(4), AKT3(6), ARHGEF11(10), CDC42(4), DLG4(4), GNA13(12), LPA(11), MAP2K4(4), MAP3K1(10), MAP3K5(14), MAPK8(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PDK1(2), PHKA2(8), PI3(1), PIK3CB(11), PLD1(9), PLD2(3), PLD3(5), PTK2(12), RDX(4), ROCK1(8), ROCK2(15), SERPINA4(2), SRF(4) 28584013 196 130 189 58 103 11 32 20 30 0 0.639 1.000 1.000 288 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(7), BID(2), BIRC2(3), BIRC3(3), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CYCS(1), DFFA(6), FADD(7), GAS2(3), LMNA(5), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), SPTAN1(68), TNFRSF10A(5), TNFRSF10B(6), TNFRSF25(3), TNFSF10(5), TRADD(2), TRAF2(5) 19334317 192 128 190 56 111 8 21 7 45 0 0.623 1.000 1.000 289 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(4), CARS(4), CARS2(7), DARS(3), DARS2(10), EARS2(2), EPRS(12), FARS2(1), FARSA(2), FARSB(6), GARS(6), HARS(6), HARS2(1), IARS(6), IARS2(10), KARS(10), LARS(11), LARS2(3), MARS(1), MARS2(5), MTFMT(2), NARS(3), NARS2(7), PARS2(4), QARS(5), RARS(6), RARS2(6), SARS(5), SARS2(5), TARS(9), TARS2(13), VARS(5), VARS2(12), WARS(5), WARS2(2), YARS(5), YARS2(8) 31619530 216 128 213 56 122 15 33 14 32 0 0.152 1.000 1.000 290 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CALR(4), CANX(6), CD4(3), CD74(2), CD8A(2), CIITA(8), CTSB(6), CTSS(1), HLA-A(7), HLA-B(4), HLA-C(4), HLA-DMB(4), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(6), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(5), HLA-F(5), HLA-G(3), HSP90AA1(26), HSP90AB1(11), HSPA5(11), IFI30(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), KIR2DL3(2), KIR3DL1(7), KIR3DL2(1), KLRC2(2), KLRC3(4), KLRC4(3), KLRD1(1), LGMN(1), LTA(1), NFYA(2), NFYB(1), NFYC(1), PDIA3(6), PSME1(2), RFX5(6), RFXANK(1), RFXAP(2), TAP1(3), TAP2(1), TAPBP(2) 26881897 203 128 195 71 99 10 37 19 38 0 0.660 1.000 1.000 291 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(4), DAXX(9), DDIT3(1), ELK1(1), GRB2(1), HMGN1(2), HRAS(16), HSPB1(1), HSPB2(4), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP3K5(14), MAP3K7(8), MAP3K9(11), MAPK14(2), MAPKAPK2(1), MAPKAPK5(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MKNK1(6), MYC(2), PLA2G4A(1), RAC1(4), RIPK1(7), RPS6KA5(9), SHC1(8), STAT1(13), TGFB1(2), TGFB3(1), TGFBR1(7), TRADD(2), TRAF2(5) 21222612 179 127 172 59 89 9 43 12 25 1 0.830 1.000 1.000 292 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(7), APC(29), ATF2(1), AXIN1(4), BMP10(3), BMP2(1), BMP4(1), BMP5(6), BMP7(4), BMPR1A(3), BMPR2(9), CHRD(7), CTNNB1(15), DVL1(5), FZD1(4), GATA4(1), GSK3B(4), MAP3K7(8), MEF2C(5), MYL2(4), NKX2-5(5), NOG(2), NPPA(2), NPPB(1), RFC1(9), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8), TGFBR3(10) 21144259 168 126 162 48 90 7 26 13 31 1 0.634 1.000 1.000 293 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A1L(5), GTF2A2(1), GTF2B(2), GTF2E1(7), GTF2E2(3), GTF2F1(5), GTF2F2(2), GTF2H1(4), GTF2H3(5), GTF2H4(1), GTF2I(16), GTF2IRD1(9), STON1(13), TAF1(10), TAF10(1), TAF12(2), TAF13(2), TAF1L(21), TAF2(10), TAF4(6), TAF4B(6), TAF5(4), TAF5L(3), TAF6(6), TAF6L(6), TAF7(3), TAF7L(6), TAF9(7), TAF9B(2), TBPL1(2) 21011536 173 126 169 52 83 9 32 20 29 0 0.835 1.000 1.000 294 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP12A(18), ATP4B(2), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ATP7A(7), ATP7B(9), COX10(4), COX5A(5), COX6A1(5), COX6C(2), COX7A1(1), COX7A2(1), COX7B(1), COX8A(1), NDUFA1(1), NDUFA10(4), NDUFA5(1), NDUFA8(4), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFS1(5), NDUFS2(3), NDUFV1(4), NDUFV2(6), PPA2(2), SDHA(9), SDHB(2), SHMT1(3), UQCRB(1), UQCRC1(2), UQCRFS1(3), UQCRH(2) 22214490 190 126 184 52 102 8 37 19 24 0 0.169 1.000 1.000 295 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(5), F11(10), F12(3), F13B(9), F2(3), F5(24), F7(8), F8(22), F9(3), FGA(17), FGB(5), FGG(7), LPA(11), PLAT(6), PLG(4), SERPINB2(3), SERPINE1(6), VWF(21) 20485546 167 125 164 49 83 8 39 20 17 0 0.511 1.000 1.000 296 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(4), ACAA2(2), ACADL(2), ACADM(1), ACADS(6), ACADSB(3), ACADVL(2), ACAT1(5), ACAT2(1), ACOX1(6), ACOX3(7), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(5), ACSL6(1), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), CYP4A11(5), CYP4A22(7), ECHS1(1), EHHADH(6), GCDH(5), HADH(5), HADHA(4), HADHB(4), HSD17B10(1), HSD17B4(5) 28516176 169 125 167 63 89 7 30 12 31 0 0.805 1.000 1.000 297 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(8), POLA2(11), POLD1(8), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLG(8), POLG2(6), POLH(10), POLI(5), POLK(12), POLM(8), POLQ(28), PRIM2(1), REV1(8), REV3L(30), RFC5(5) 23539553 190 125 189 42 97 12 30 21 30 0 0.185 1.000 1.000 298 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(8), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH3B1(4), ALDH3B2(5), ALDH7A1(1), ALDH9A1(7), AMDHD1(4), AOC2(5), AOC3(6), ASPA(2), CARM1(6), CNDP1(4), DDC(8), FTCD(3), HAL(6), HARS(6), HARS2(1), HDC(6), HEMK1(1), HNMT(2), LCMT1(2), LCMT2(12), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), PRPS1(3), PRPS2(1), UROC1(6), WBSCR22(6) 22963508 168 124 164 49 78 7 40 17 26 0 0.170 1.000 1.000 299 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(7), ELK1(1), GNAS(12), GNB1(7), GRB2(1), HRAS(16), IGF1R(11), ITGB1(3), KLK2(1), MAP2K1(3), MAP2K2(5), MAPK3(8), MKNK1(6), MKNK2(3), MYC(2), NGFR(4), PDGFRA(16), PPP2CA(2), PTPRR(7), RAF1(4), RPS6KA1(5), RPS6KA5(9), SHC1(8), SOS1(23), SRC(5), STAT3(6) 19270645 175 123 167 57 82 7 49 22 15 0 0.679 1.000 1.000 300 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(3), BLNK(8), ELK1(1), FOS(4), GRB2(1), HRAS(16), JUN(4), LYN(5), MAP2K1(3), MAP3K1(10), MAPK3(8), MAPK8IP3(11), PAPPA(15), RAC1(4), RPS6KA1(5), RPS6KA3(8), SHC1(8), SOS1(23), SYK(8), VAV1(8), VAV2(8), VAV3(7) 18512847 169 123 160 52 81 3 46 21 18 0 0.559 1.000 1.000 301 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(4), AZIN1(5), BTG1(3), CBX3(1), CEBPB(3), CLDN5(3), CLOCK(8), CRY1(3), CRY2(4), DAZAP2(3), DNAJA1(4), EIF4G2(10), ETV6(12), GFRA1(4), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(10), IDI1(2), MYF6(5), NCKAP1(12), NCOA4(6), NR1D2(10), PER1(6), PER2(6), PIGF(2), PPP1R3C(4), PPP2CB(2), PSMA4(3), PURA(5), SF3A3(7), SUMO3(2), TOB1(5), TUBB3(5), UGP2(9), VAPA(6), ZFR(5) 21198935 187 122 180 59 95 11 33 18 30 0 0.885 1.000 1.000 302 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA1(4), ACAA2(2), ACADM(1), ACADS(6), ACAT1(5), ACAT2(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), AOX1(8), AUH(2), BCAT1(4), BCAT2(3), BCKDHA(4), BCKDHB(1), DBT(6), DLD(7), ECHS1(1), EHHADH(6), HADH(5), HADHA(4), HADHB(4), HMGCL(1), HMGCS1(9), HMGCS2(7), HSD17B10(1), HSD17B4(5), IVD(2), MCCC1(12), MCCC2(8), MCEE(3), MUT(9), OXCT1(4), OXCT2(2), PCCA(4), PCCB(4) 25068080 171 122 168 53 98 7 20 18 28 0 0.663 1.000 1.000 303 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), AGTR1(3), ATF2(1), CALM1(2), CALM2(2), EGFR(7), ELK1(1), GNAQ(3), GRB2(1), HRAS(16), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), PAK1(4), PRKCA(3), PTK2(12), PTK2B(6), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SRC(5), SYT1(6) 19422997 171 121 162 51 75 11 40 21 24 0 0.592 1.000 1.000 304 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(3), ACTR3(2), ARHGAP1(1), ARHGAP4(3), ARHGAP5(12), ARHGAP6(8), ARHGEF1(8), ARHGEF11(10), ARHGEF5(6), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), BAIAP2(5), CFL1(1), DIAPH1(5), GSN(2), LIMK1(6), MYL2(4), MYLK(15), OPHN1(8), PFN1(4), PIP5K1A(8), PIP5K1B(3), PPP1R12B(10), ROCK1(8), SRC(5), TLN1(17), VCL(4) 26229374 173 121 171 53 86 6 38 22 21 0 0.567 1.000 1.000 305 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH4A1(4), ALDH9A1(7), AOC2(5), AOC3(6), ARG1(2), ARG2(3), ASL(6), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), GATM(3), GLUD1(6), GOT1(2), MAOA(4), MAOB(2), NOS1(15), NOS3(11), OAT(1), ODC1(4), OTC(2), P4HA1(7), P4HA3(3), P4HB(6), PYCR1(3), RARS(6), SMS(1) 25549625 169 120 164 55 92 4 30 20 22 1 0.415 1.000 1.000 306 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(1), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), FPGT(10), FUK(9), GMDS(6), GMPPA(3), GMPPB(5), HK1(15), HK2(11), HK3(8), HSD3B7(2), KHK(1), LHPP(2), MPI(7), MTMR1(8), MTMR2(6), MTMR6(8), PFKFB1(5), PFKFB2(3), PFKFB3(7), PFKL(1), PFKM(5), PFKP(4), PGM2(2), PMM1(6), PMM2(2), RDH12(2), RDH13(1), SORD(1), TPI1(1), TSTA3(2) 21450419 161 119 158 67 85 5 31 19 21 0 0.873 1.000 1.000 307 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(2), AKR1B10(1), ALAS1(12), ALAS2(3), AMT(3), AOC2(5), AOC3(6), BHMT(1), CBS(2), CHDH(5), CHKA(5), CHKB(4), CTH(5), DLD(7), DMGDH(5), GARS(6), GATM(3), GCAT(2), GLDC(8), GNMT(3), HSD3B7(2), MAOA(4), MAOB(2), PEMT(1), PHGDH(3), PIPOX(4), PISD(3), PSAT1(6), PSPH(7), RDH12(2), RDH13(1), SARDH(2), SARS(5), SARS2(5), SDS(2), SHMT1(3), SHMT2(2), TARS(9), TARS2(13) 24615860 166 119 163 69 82 9 31 14 30 0 0.921 1.000 1.000 308 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(6), CALM1(2), CALM2(2), ELK1(1), FOS(4), GNAI1(4), GNAQ(3), GNAS(12), GNB1(7), HRAS(16), JUN(4), MAP2K1(3), MAPK3(8), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), RAF1(4), RPS6KA3(8), SYT1(6) 20306863 183 118 174 51 75 14 50 20 24 0 0.344 1.000 1.000 309 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(2), ALAS1(12), ALAS2(3), AMT(3), AOC2(5), AOC3(6), ATP6V0C(2), BHMT(1), CBS(2), CHDH(5), CHKA(5), CHKB(4), CPT1B(4), CTH(5), DLD(7), DMGDH(5), GARS(6), GATM(3), GCAT(2), GLDC(8), MAOA(4), MAOB(2), PEMT(1), PISD(3), PLCB2(6), PLCG1(12), PLCG2(6), PSPH(7), SARDH(2), SARS(5), SHMT1(3), SHMT2(2), TARS(9) 24201048 154 116 151 61 76 7 33 11 27 0 0.843 1.000 1.000 310 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(5), ALAS1(12), ALAS2(3), BLVRA(5), BLVRB(1), COX10(4), COX15(4), CP(5), CPOX(5), EARS2(2), EPRS(12), FECH(2), FTH1(8), FTMT(2), GUSB(3), HCCS(3), HMOX1(3), HMOX2(2), MMAB(2), PPOX(6), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), UROD(4), UROS(4) 24518901 169 116 167 57 82 7 24 24 32 0 0.834 1.000 1.000 311 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(11), ACTG2(2), ADCY3(5), ADCY9(8), AK1(1), ARF3(1), ARF4(1), ARF5(2), ARF6(1), ARL4D(1), ATP6V0A1(12), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ERO1L(4), GNAS(12), PDIA4(5), PLCG1(12), PLCG2(6), PRKCA(3), SEC61A1(5), SEC61A2(7), TRIM23(5) 21561162 161 115 161 58 83 11 29 18 20 0 0.667 1.000 1.000 312 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(27), ACAT1(5), ACAT2(1), ADH5(1), AKR1B1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), DLAT(6), DLD(7), GLO1(2), GRHPR(2), HAGH(2), LDHB(2), LDHC(4), LDHD(3), MDH1(3), ME1(5), ME2(1), ME3(6), PC(10), PCK1(9), PDHA1(5), PDHA2(6), PDHB(1), PKLR(8) 21467689 151 115 148 54 81 3 32 14 21 0 0.791 1.000 1.000 313 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(5), ALDOB(3), ALDOC(2), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GAPDHS(2), GCK(1), GOT1(2), GPI(4), HK1(15), HK2(11), HK3(8), LDHAL6B(2), LDHB(2), LDHC(4), MDH1(3), PC(10), PCK1(9), PDHA1(5), PDHA2(6), PDHB(1), PDHX(4), PFKL(1), PFKM(5), PFKP(4), PGAM1(1), PGAM2(4), PGK1(2), PKLR(8), TNFAIP1(2), TPI1(1) 24702421 159 114 157 74 78 5 42 15 19 0 0.971 1.000 1.000 314 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(3), CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), HRAS(16), IL6(4), IL6R(4), IL6ST(9), JAK1(9), JAK2(8), JAK3(12), JUN(4), MAP2K1(3), MAPK3(8), PTPN11(4), RAF1(4), SHC1(8), SOS1(23), SRF(4), STAT3(6) 13848961 146 114 137 31 72 5 33 18 18 0 0.0444 1.000 1.000 315 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(6), CALM1(2), CALM2(2), CRKL(1), GNAQ(3), GRB2(1), HRAS(16), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP3K1(10), MAPK14(2), MAPK3(8), MAPK8(5), PAK1(4), PLCG1(12), PRKCA(3), PTK2B(6), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SRC(5), SYT1(6) 16554880 153 113 144 49 72 7 39 16 19 0 0.700 1.000 1.000 316 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(5), AKT1(3), AKT2(4), AKT3(6), DAG1(3), GNAQ(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PDK1(2), PHKA2(8), PIK3CB(11), PITX2(5), PLD1(9), PLD2(3), PLD3(5), VN1R1(1) 26038876 165 113 161 69 91 7 31 12 24 0 0.941 1.000 1.000 317 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(4), ARSD(7), ARSE(2), ASAH1(4), B4GALT6(2), CERK(2), DEGS1(3), ENPP7(4), GAL3ST1(5), GALC(4), GBA(4), GLA(3), GLB1(5), LCT(16), NEU1(2), NEU2(3), NEU3(7), NEU4(5), PPAP2A(5), PPAP2B(3), PPAP2C(1), SGMS1(3), SGMS2(4), SGPP1(3), SGPP2(2), SMPD1(4), SMPD2(2), SMPD3(5), SMPD4(9), SPHK1(1), SPHK2(10), SPTLC1(4), SPTLC2(5), UGCG(3), UGT8(6) 20576642 152 112 152 53 66 5 45 18 18 0 0.520 1.000 1.000 318 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(4), AASDH(13), AASS(11), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), ATP6V0C(2), BBOX1(4), DLST(1), DOT1L(21), ECHS1(1), EHHADH(6), EHMT1(8), EHMT2(12), GCDH(5), HADHA(4), PLOD1(3), PLOD2(5), PLOD3(5), SDS(2), SHMT1(3), SHMT2(2), TMLHE(2) 21430958 153 112 152 74 82 7 30 14 20 0 0.998 1.000 1.000 319 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(10), CALM1(2), CALM2(2), CAPN2(2), CAPNS2(1), EP300(77), HDAC1(4), HDAC2(3), MEF2D(3), NFATC1(13), NFATC2(13), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKCA(3), SYT1(6) 14201552 156 112 152 39 57 14 23 20 41 1 0.341 1.000 1.000 320 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(2), ABAT(4), ACADS(6), ACAT1(5), ACAT2(1), ACSM1(2), AKR1B10(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), BDH2(3), DDHD1(11), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADH(5), HADHA(4), HMGCL(1), HMGCS1(9), HMGCS2(7), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(3), L2HGDH(4), OXCT1(4), OXCT2(2), PDHA1(5), PDHA2(6), PDHB(1), PLA1A(3), PPME1(2), PRDX6(5), RDH12(2), RDH13(1) 23540402 152 111 151 62 82 10 24 18 18 0 0.941 1.000 1.000 321 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX12(2), ALOX12B(2), ALOX15(5), ALOX15B(3), ALOX5(4), CBR1(2), CBR3(1), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(3), CYP2E1(4), CYP2J2(2), CYP2U1(2), CYP4A11(5), CYP4A22(7), CYP4F2(7), CYP4F3(3), DHRS4(2), EPHX2(4), GGT1(5), GPX2(1), GPX3(1), GPX5(2), GPX6(3), GPX7(4), LTA4H(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PTGDS(1), PTGES2(2), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3) 22520009 144 110 144 68 61 9 38 14 22 0 0.932 1.000 1.000 322 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(8), EGF(17), EGFR(7), GRB2(1), HRAS(16), MAP2K1(3), MAPK3(8), PTPRB(16), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SPRY1(3), SPRY2(5), SPRY3(3), SPRY4(4), SRC(5) 14534008 139 110 132 37 67 6 38 15 13 0 0.344 1.000 1.000 323 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(2), ACP5(8), ACPP(11), ACPT(4), ALPI(5), ALPL(4), ALPP(3), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(3), CYP2D6(5), CYP2E1(4), CYP2F1(4), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(9), CYP4B1(5), CYP51A1(4), PON1(6) 17021974 148 106 143 63 73 10 35 12 18 0 0.749 1.000 1.000 324 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ALDH4A1(4), CAD(15), CPS1(13), EARS2(2), EPRS(12), GAD1(8), GAD2(6), GCLC(6), GCLM(2), GFPT1(5), GFPT2(5), GLS(3), GLS2(4), GLUD1(6), GLUD2(10), GLUL(3), GMPS(5), GNPNAT1(3), GOT1(2), GPT(2), GPT2(1), GSR(2), GSS(7), NADSYN1(6), NAGK(5), PPAT(4), QARS(5) 22982504 150 106 149 59 74 11 33 14 18 0 0.906 1.000 1.000 325 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(4), ACAA2(2), ACADL(2), ACADM(1), ACADS(6), ACADSB(3), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), AOX1(8), BCAT1(4), BCKDHA(4), BCKDHB(1), ECHS1(1), EHHADH(6), HADHA(4), HADHB(4), HMGCL(1), IVD(2), MCCC1(12), MCCC2(8), MCEE(3), MUT(9), OXCT1(4), PCCA(4), PCCB(4), SDS(2) 20998937 138 106 135 54 78 7 16 14 23 0 0.959 1.000 1.000 326 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(4), ABAT(4), ACY3(8), ADSL(4), ADSS(4), ADSSL1(4), AGXT(2), AGXT2(2), ASL(6), ASNS(1), ASPA(2), ASRGL1(3), ASS1(2), CAD(15), CRAT(10), DARS(3), DARS2(10), DDO(1), DLAT(6), DLD(7), GAD1(8), GAD2(6), GOT1(2), GPT(2), GPT2(1), NARS(3), NARS2(7), PC(10), PDHA1(5), PDHA2(6), PDHB(1) 21969274 153 105 151 58 84 9 30 12 18 0 0.868 1.000 1.000 327 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(2), ARG2(3), ASL(6), ASS1(2), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), EPRS(12), GATM(3), GLUD1(6), GLUD2(10), GOT1(2), LAP3(4), NOS1(15), NOS3(11), OAT(1), OTC(2), P4HA1(7), P4HA3(3), PARS2(4), PRODH(3), PYCR1(3), PYCR2(1), PYCRL(3), RARS(6), RARS2(6) 20764080 152 105 145 46 89 7 26 12 17 1 0.403 1.000 1.000 328 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), HRAS(16), IL2(1), IL2RA(1), IL2RB(2), IL2RG(5), JAK1(9), JAK3(12), JUN(4), LCK(2), MAP2K1(3), MAPK3(8), MAPK8(5), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5), SYK(8) 13446116 134 105 125 43 55 5 38 18 18 0 0.524 1.000 1.000 329 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(27), ACACB(20), ACADM(1), ACAT1(5), ACAT2(1), ACSS1(7), ACSS2(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), MCEE(3), MLYCD(2), MUT(9), PCCA(4), PCCB(4), SUCLA2(2), SUCLG1(2), SUCLG2(3) 23121877 139 104 138 48 72 6 22 18 21 0 0.741 1.000 1.000 330 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(5), CAPN2(2), CAPNS2(1), CXCR3(3), EGF(17), EGFR(7), HRAS(16), ITGA1(7), ITGB1(3), MAPK3(8), MYL2(4), MYLK(15), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTK2(12), PXN(3), TLN1(17) 18950043 144 104 138 47 60 10 44 12 18 0 0.594 1.000 1.000 331 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BAD(2), BRAF(9), CREB5(10), DUSP4(2), DUSP6(7), DUSP9(3), EEF2K(7), EIF4E(2), GRB2(1), MAP2K1(3), MAP2K2(5), MAP3K8(5), MAPK3(8), MKNK1(6), MKNK2(3), MOS(2), NFKB1(3), RAP1A(1), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), SHC1(8), SOS1(23), SOS2(8), TRAF3(2) 17148106 145 104 143 42 74 5 25 19 22 0 0.617 1.000 1.000 332 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(2), CALM2(2), CDKN1A(38), GNAQ(3), MARCKS(2), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKCA(3), SP1(10), SP3(3), SYT1(6) 12217340 139 103 131 36 53 10 23 10 38 5 0.661 1.000 1.000 333 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(10), ACO1(4), ACO2(5), CLYBL(5), CS(3), DLD(7), DLST(1), FH(7), IDH1(9), IDH2(2), IDH3A(3), IDH3B(4), IDH3G(1), MDH1(3), OGDH(21), OGDHL(10), PC(10), PCK1(9), PCK2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(3), SUCLA2(2), SUCLG1(2), SUCLG2(3) 17417733 139 103 136 58 75 4 31 13 16 0 0.891 1.000 1.000 334 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(21), BAIAP2(5), CASP1(9), CASP3(3), CASP7(5), CASP8(14), GAPDH(3), INSR(10), ITCH(12), MAGI1(15), MAGI2(17), RERE(15), WWP1(5), WWP2(5) 13988690 139 103 135 36 80 3 27 13 16 0 0.265 1.000 1.000 335 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(8), COMT(3), DBH(4), DCT(8), DDC(8), FAH(3), GOT1(2), GSTZ1(2), HGD(4), HPD(4), MAOA(4), MAOB(2), TAT(5), TH(2), TPO(16), TYR(12) 18344190 140 103 140 42 59 3 40 13 25 0 0.195 1.000 1.000 336 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(3), CFL1(1), GNAQ(3), GNAS(12), GNB1(7), HRAS(16), LIMK1(6), MAP2K1(3), MAPK3(8), MYL2(4), NOX1(4), PIK3C2G(11), PLCB1(16), PPP1R12B(10), PRKCA(3), PTK2(12), RAF1(4), ROCK2(15) 14578472 138 102 130 39 68 7 34 18 11 0 0.564 1.000 1.000 337 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(5), AKR1D1(5), ARSB(8), ARSD(7), ARSE(2), CYP11B1(4), CYP11B2(13), HSD11B2(3), HSD17B2(6), HSD17B3(1), HSD17B8(4), HSD3B1(5), HSD3B2(5), SRD5A1(4), STS(5), SULT1E1(1), SULT2A1(4), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4) 15863593 124 101 124 36 59 8 29 16 12 0 0.245 1.000 1.000 338 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(4), CSF1R(11), DDX20(10), E2F1(3), E2F4(2), ETS1(5), ETS2(5), ETV3(1), FOS(4), HDAC2(3), HDAC5(6), HRAS(16), JUN(4), NCOR2(19), RBL1(9), RBL2(9), SIN3A(12), SIN3B(5) 14959461 128 101 120 36 58 1 35 14 20 0 0.287 1.000 1.000 339 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(7), GTF2A1(3), GTF2B(2), GTF2E1(7), GTF2F1(5), HDAC3(1), NCOA1(24), NCOA2(12), NCOA3(16), NCOR2(19), POLR2A(13), RARA(4), RXRA(25), TBP(2) 14408276 140 101 124 44 78 5 24 9 24 0 0.709 1.000 1.000 340 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(7), ACTN2(10), CAPN1(5), CAPNS2(1), ITGA1(7), ITGB1(3), ITGB3(9), PTK2(12), PXN(3), RAC1(4), SPTAN1(68), SRC(5), TLN1(17) 16549937 155 101 154 42 77 6 24 9 39 0 0.281 1.000 1.000 341 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(5), ARSB(8), FUCA1(2), FUCA2(6), GALNS(3), GBA(4), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), HGSNAT(4), HPSE(4), HPSE2(4), HYAL2(4), IDS(4), IDUA(1), LCT(16), MAN2B1(8), MAN2B2(7), MAN2C1(8), MANBA(5), NAGLU(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5), SPAM1(2) 19832019 132 100 131 44 71 3 26 19 13 0 0.455 1.000 1.000 342 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(2), CDC42(4), CREB5(10), DUSP1(3), DUSP10(4), EEF2K(7), EIF4E(2), ELK1(1), GADD45A(1), HSPB1(1), IL1R1(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K10(2), MAP3K4(20), MAP3K5(14), MAP3K7(8), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPKAPK2(1), MAPKAPK5(3), MKNK1(6), MKNK2(3), MYEF2(5), NFKB1(3), NR2C2(6), SRF(4), TRAF6(1) 19295118 138 100 136 43 69 7 31 13 18 0 0.646 1.000 1.000 343 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(3), CHUK(7), ELK1(1), FOS(4), IKBKB(11), IRAK1(3), JUN(4), LY96(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP3K7(8), MAPK14(2), MAPK8(5), MYD88(1), NFKB1(3), NFKBIA(6), PPARA(1), RELA(6), TLR10(12), TLR2(3), TLR3(10), TLR4(6), TLR6(6), TLR7(9), TLR9(6), TOLLIP(3), TRAF6(1) 21134052 143 100 141 54 73 8 23 11 28 0 0.930 1.000 1.000 344 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(6), CD3E(2), CD3G(2), CD4(3), CREBBP(50), CSK(7), GNAS(12), GNB1(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTPRC(19), ZAP70(2) 13350597 137 99 133 41 49 6 35 14 32 1 0.453 1.000 1.000 345 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(6), CD3E(2), CD3G(2), CD4(3), CREBBP(50), CSK(7), GNAS(12), GNB1(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTPRC(19), ZAP70(2) 13350597 137 99 133 41 49 6 35 14 32 1 0.453 1.000 1.000 346 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(7), CALCR(9), CALCRL(8), CD97(5), CRHR1(2), CRHR2(3), ELTD1(10), EMR1(6), EMR2(6), GHRHR(3), GIPR(3), GLP1R(3), GLP2R(2), GPR64(7), LPHN1(9), LPHN2(21), LPHN3(21), SCTR(4), VIPR1(1), VIPR2(4) 15363566 134 99 134 70 48 7 40 14 25 0 0.985 1.000 1.000 347 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(4), ACAA2(2), ACAD8(3), ACAD9(5), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1B10(1), AKR1C4(5), AKR1D1(5), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), BAAT(3), CEL(8), CYP27A1(9), CYP7A1(10), HADHB(4), HSD3B7(2), LIPA(3), RDH12(2), RDH13(1), SLC27A5(9), SOAT1(5), SOAT2(1), SRD5A1(4) 18295273 134 98 128 46 68 8 27 9 22 0 0.427 1.000 1.000 348 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(11), ELK1(1), EPO(2), EPOR(5), FOS(4), GRB2(1), HRAS(16), JAK2(8), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PLCG1(12), PTPN6(2), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5) 12505991 123 97 114 35 62 5 26 13 17 0 0.391 1.000 1.000 349 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(6), CHIA(7), CHIT1(7), CMAS(2), CTBS(2), CYB5R1(4), CYB5R3(4), GFPT1(5), GFPT2(5), GNE(8), GNPDA1(3), GNPDA2(2), GNPNAT1(3), HEXA(3), HEXB(2), HK1(15), HK2(11), HK3(8), LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), NAGK(5), NPL(2), PGM3(1), RENBP(4), UAP1(5) 16623480 138 97 137 47 75 7 25 15 16 0 0.724 1.000 1.000 350 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRA2A(3), ADRA2C(3), ADRB1(3), ADRB2(3), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), HRH1(9), HRH2(1), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5) 14857312 119 95 116 67 59 5 34 11 10 0 0.847 1.000 1.000 351 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(4), CDK7(6), ERCC3(7), GTF2A2(1), GTF2B(2), GTF2E1(7), GTF2E2(3), GTF2F2(2), GTF2H1(4), GTF2H4(1), ILK(3), MNAT1(4), POLR1A(18), POLR1B(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3B(6), POLR3D(1), POLR3E(4), POLR3H(2), TAF12(2), TAF13(2), TAF5(4), TAF6(6), TAF7(3), TAF9(7), TBP(2) 20384628 141 95 139 56 84 8 17 12 20 0 0.980 1.000 1.000 352 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(9), ASPH(3), COPS5(1), EDN1(2), EP300(77), EPO(2), HIF1A(6), JUN(4), NOS3(11), P4HB(6), VHL(2) 9849708 123 94 117 29 54 6 11 16 35 1 0.409 1.000 1.000 353 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ACADL(2), ACADM(1), ACADSB(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), AOC2(5), AOC3(6), CNDP1(4), DPYD(14), DPYS(13), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), MLYCD(2), SDS(2), SMS(1), UPB1(4) 16930150 119 93 118 46 54 9 25 17 14 0 0.878 1.000 1.000 354 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(4), CAD(15), CPS1(13), EPRS(12), GAD1(8), GAD2(6), GCLC(6), GCLM(2), GFPT1(5), GLS(3), GLS2(4), GLUD1(6), GLUL(3), GMPS(5), GOT1(2), GPT(2), GPT2(1), GSS(7), NADSYN1(6), PPAT(4), QARS(5) 19339820 123 93 122 50 60 10 24 12 17 0 0.940 1.000 1.000 355 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(16), C5(9), C6(9), C7(4), ICAM1(7), IL1A(1), IL6(4), ITGA4(19), ITGAL(17), ITGB1(3), ITGB2(7), SELP(7), SELPLG(3), TNF(4), VCAM1(14) 14431991 124 93 124 42 66 7 25 11 15 0 0.668 1.000 1.000 356 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(27), ACADL(2), ACADM(1), ACADSB(3), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), LDHB(2), LDHC(4), MCEE(3), MLYCD(2), MUT(9), PCCA(4), PCCB(4), SDS(2), SUCLA2(2), SUCLG1(2), SUCLG2(3) 19322692 124 93 123 44 67 5 19 15 18 0 0.857 1.000 1.000 357 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(1), B4GALT1(4), B4GALT2(1), G6PC(2), G6PC2(2), GAA(5), GALK1(2), GALT(1), GANC(7), GCK(1), GLA(3), GLB1(5), HK1(15), HK2(11), HK3(8), HSD3B7(2), LCT(16), MGAM(13), PFKL(1), PFKM(5), PFKP(4), PGM1(3), PGM3(1), RDH12(2), RDH13(1), UGP2(9) 22312520 127 92 124 65 65 5 24 14 19 0 0.989 1.000 1.000 358 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(2), ALOX15(5), ALOX5(4), CBR1(2), CBR3(1), CYP4F2(7), CYP4F3(3), EPX(6), GGT1(5), LPO(8), LTA4H(3), MPO(4), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), PTGDS(1), PTGES2(2), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3), TPO(16) 16145160 124 92 123 46 58 5 30 11 20 0 0.507 1.000 1.000 359 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(29), ASAH1(4), CAMP(1), CASP3(3), CERK(2), CREB5(10), CXCL2(1), DAG1(3), EPHB2(10), FOS(4), GNAQ(3), ITPKA(4), ITPKB(5), JUN(4), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5) 16506815 126 92 123 37 62 4 28 12 20 0 0.509 1.000 1.000 360 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), DAG1(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), NFAT5(15), PDE6A(4), PDE6B(5), PDE6C(5), PDE6H(1), SLC6A13(2), TF(4) 20732514 130 92 128 63 76 5 22 9 18 0 0.991 1.000 1.000 361 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM2(2), CHUK(7), EGR2(3), EGR3(3), GNAQ(3), MAP3K1(10), MYC(2), NFATC1(13), NFATC2(13), NFKB1(3), NFKBIA(6), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RELA(6), SYT1(6), VIPR2(4) 16257616 132 92 132 45 61 12 29 8 22 0 0.763 1.000 1.000 362 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(3), ARRB2(4), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CLCA1(8), CLCA2(5), CLCA4(12), CNGA3(4), CNGB1(13), GNAL(4), GUCA1B(1), GUCA1C(1), PDE1C(15), PRKACA(2), PRKACB(2), PRKACG(2), PRKG1(8), PRKG2(8), PRKX(1) 17727032 125 91 125 58 63 5 23 14 20 0 0.987 1.000 1.000 363 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), FPGT(10), GCK(1), GMDS(6), GMPPA(3), GMPPB(5), HK1(15), HK2(11), HK3(8), KHK(1), MPI(7), PFKFB1(5), PFKFB3(7), PFKM(5), PFKP(4), PMM1(6), PMM2(2), SORD(1), TPI1(1) 13797654 115 90 112 49 59 4 23 13 16 0 0.818 1.000 1.000 364 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(2), F2RL3(2), GNAI1(4), GNB1(7), HRAS(16), ITGA1(7), ITGB1(3), MAP2K1(3), MAPK3(8), PLA2G4A(1), PLCB1(16), PRKCA(3), PTGS1(2), PTK2(12), RAF1(4), SRC(5), SYK(8), TBXAS1(3) 14171759 109 90 102 43 45 8 32 13 11 0 0.934 1.000 1.000 365 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(4), ACAA2(2), ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1C4(5), AKR1D1(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), BAAT(3), CEL(8), CYP27A1(9), CYP7A1(10), HADHB(4), SOAT2(1), SRD5A1(4) 13483670 113 88 108 32 52 8 26 9 18 0 0.190 1.000 1.000 366 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(7), APC(29), AXIN1(4), BTRC(4), CTNNB1(15), DLL1(9), DVL1(5), FZD1(4), GSK3B(4), NOTCH1(17), PSEN1(8) 12262160 106 88 102 27 55 3 21 4 21 2 0.455 1.000 1.000 367 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(6), GABBR1(6), GPRC5A(2), GPRC5B(1), GPRC5C(3), GPRC5D(1), GRM1(22), GRM2(10), GRM3(8), GRM4(9), GRM5(18), GRM7(12), GRM8(8) 12244303 106 87 105 48 45 6 29 12 14 0 0.737 1.000 1.000 368 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(3), DLAT(6), DLD(7), DLST(1), FH(7), IDH2(2), IDH3A(3), IDH3B(4), IDH3G(1), MDH1(3), OGDH(21), PC(10), PDHA1(5), PDHA2(6), PDHB(1), PDHX(4), PDK1(2), PDK2(2), PDK3(1), PDK4(1), PDP2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(3), SUCLA2(2), SUCLG1(2), SUCLG2(3) 16514949 120 87 116 44 64 5 29 10 12 0 0.800 1.000 1.000 369 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(4), BIRC2(3), BIRC3(3), CASP3(3), CASP8(14), CFLAR(2), FADD(7), JUN(4), MAP2K4(4), MAP3K3(3), MAP3K7(8), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NR2C2(6), RALBP1(2), RIPK1(7), TNF(4), TNFAIP3(7), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5) 15779448 124 87 119 33 77 4 17 8 18 0 0.255 1.000 1.000 370 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(4), B4GALT2(1), FBP2(2), G6PC(2), GAA(5), GALK1(2), GALT(1), GANAB(16), GCK(1), GLA(3), GLB1(5), HK1(15), HK2(11), HK3(8), LCT(16), MGAM(13), PFKM(5), PFKP(4), PGM1(3), PGM3(1) 18802492 120 86 119 56 60 4 26 12 18 0 0.954 1.000 1.000 371 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(4), ARSB(8), ARSD(7), ARSE(2), ASAH1(4), GAL3ST1(5), GALC(4), GBA(4), GLA(3), GLB1(5), LCT(16), NEU1(2), NEU2(3), NEU3(7), NEU4(5), PPAP2A(5), PPAP2B(3), PPAP2C(1), SMPD1(4), SMPD2(2), SPTLC1(4), SPTLC2(5), UGCG(3) 13934575 106 86 106 33 49 5 26 14 12 0 0.404 1.000 1.000 372 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(6), AP2A1(6), AP2M1(2), BIN1(5), CALM1(2), CALM2(2), DNM1(11), EPN1(1), EPS15(10), NME1(1), NME2(1), PICALM(8), PPP3CA(7), PPP3CB(6), PPP3CC(4), SYNJ1(20), SYNJ2(8), SYT1(6) 12615416 106 86 106 32 58 5 12 13 18 0 0.698 1.000 1.000 373 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM2(2), DLG4(4), GRIN1(7), GRIN2A(14), GRIN2B(10), GRIN2C(10), GRIN2D(9), NOS1(15), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), SYT1(6) 14795900 119 85 116 43 46 11 29 17 15 1 0.665 1.000 1.000 374 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(5), DLG4(4), EPHB2(10), F2(3), F2RL1(5), F2RL2(2), F2RL3(2), JUN(4), MAP2K5(4), MAPK7(3), MAPK8(5), MYEF2(5), PLD1(9), PLD2(3), PLD3(5), PTK2(12), RAF1(4), RASAL1(8), SRC(5), TEC(10), VAV1(8) 15908002 116 85 114 43 56 10 20 15 15 0 0.822 1.000 1.000 375 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(7), IFNA1(1), IFNB1(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1RAP(5), IL1RN(1), IL6(4), IRAK1(3), IRAK2(5), IRAK3(9), JUN(4), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAP3K7(8), MAPK14(2), MAPK8(5), MYD88(1), NFKB1(3), NFKBIA(6), RELA(6), TGFB1(2), TGFB3(1), TNF(4), TOLLIP(3), TRAF6(1) 17179234 115 84 113 39 63 3 16 9 24 0 0.772 1.000 1.000 376 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), AGT(3), AGTR2(4), EDN1(2), EDNRA(4), EDNRB(8), EGF(17), EGFR(7), FOS(4), HRAS(16), JUN(4), MYC(2), NFKB1(3), PLCG1(12), PRKCA(3), RELA(6) 11964577 101 83 93 38 46 8 32 5 10 0 0.789 1.000 1.000 377 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), AOC2(5), AOC3(6), ASPA(2), CNDP1(4), DDC(8), HAL(6), HARS(6), HDC(6), HNMT(2), MAOA(4), MAOB(2), PRPS1(3), PRPS2(1) 14173380 97 83 96 31 40 4 27 9 17 0 0.400 1.000 1.000 378 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(13), APOA1(2), APOA4(4), APOC1(1), APOC2(1), APOC3(1), APOE(2), CETP(2), CYP7A1(10), DGAT1(3), HMGCR(7), LCAT(3), LDLR(10), LIPC(6), LPL(4), LRP1(36), SCARB1(3), SOAT1(5) 15957453 113 83 113 45 57 5 22 10 19 0 0.769 1.000 1.000 379 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(17), EGFR(7), MAP2K1(3), MAP3K1(10), MAPK14(2), NCOR2(19), RARA(4), RXRA(25), THRA(2), THRB(1) 9957695 90 82 77 24 42 4 22 5 17 0 0.310 1.000 1.000 380 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(6), CBS(2), CTH(5), GGT1(5), HEMK1(1), LCMT1(2), LCMT2(12), MARS(1), MARS2(5), MAT1A(4), MAT2B(1), METTL2B(3), METTL6(5), PAPSS1(4), PAPSS2(2), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SCLY(2), SEPHS1(2), SEPHS2(1), WBSCR22(6) 14482008 96 82 92 36 53 4 22 8 9 0 0.711 1.000 1.000 381 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(5), ALOX5(4), CYP1A2(4), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(3), CYP2E1(4), CYP2J2(2), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), HSD3B7(2), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), RDH12(2), RDH13(1) 13924185 96 82 96 40 43 4 21 10 18 0 0.811 1.000 1.000 382 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(6), CAP1(7), CCNB1(5), CDC25C(2), GNAI1(4), GNAS(12), GNB1(7), HRAS(16), MAPK3(8), MYT1(10), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RPS6KA1(5), SRC(5) 11955968 111 82 104 30 44 6 39 12 10 0 0.225 1.000 1.000 383 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(7), ARHGDIB(1), BIRC2(3), BIRC3(3), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), DFFA(6), GZMB(2), LMNA(5), LMNB1(4), LMNB2(7), PRF1(7) 11239631 92 81 92 32 53 4 15 7 13 0 0.874 1.000 1.000 384 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), DDC(8), EPX(6), ESCO1(3), ESCO2(3), GOT1(2), HPD(4), LPO(8), MAOA(4), MAOB(2), MIF(1), MPO(4), NAT6(1), PNPLA3(4), PRDX6(5), SH3GLB1(1), TAT(5), TPO(16) 19882147 105 81 105 26 47 4 30 9 15 0 0.126 1.000 1.000 385 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ACADM(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), CNDP1(4), DPYD(14), DPYS(13), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), MLYCD(2), SMS(1), SRM(3), UPB1(4) 15706845 104 81 104 38 45 8 22 15 14 0 0.785 1.000 1.000 386 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), C1GALT1(4), C1GALT1C1(3), GALNT1(5), GALNT10(2), GALNT11(4), GALNT12(4), GALNT13(5), GALNT14(3), GALNT2(7), GALNT3(5), GALNT4(3), GALNT5(6), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GALNTL5(8), GCNT1(5), GCNT3(3), GCNT4(5), OGT(5), ST3GAL1(1), ST3GAL2(3), ST6GALNAC1(8), WBSCR17(9) 18825856 117 81 117 38 57 9 26 11 14 0 0.647 1.000 1.000 387 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(4), DARS(3), EPRS(12), FARS2(1), GARS(6), HARS(6), IARS(6), KARS(10), LARS(11), LARS2(3), MARS(1), MARS2(5), NARS(3), QARS(5), RARS(6), SARS(5), TARS(9), WARS(5), WARS2(2), YARS(5) 18745148 112 80 112 39 66 6 14 8 18 0 0.818 1.000 1.000 388 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(8), CSF1R(11), EGF(17), EGFR(7), GRB2(1), MET(19), PDGFRA(16), PRKCA(3), SH3GLB1(1), SH3GLB2(1), SH3KBP1(8), SRC(5) 11321290 97 80 96 40 41 5 29 12 10 0 0.945 1.000 1.000 389 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(6), G6PD(3), GCLC(6), GCLM(2), GGT1(5), GPX2(1), GPX3(1), GPX5(2), GPX6(3), GPX7(4), GSR(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(3), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(4), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), IDH1(9), IDH2(2), MGST1(1), MGST2(1), MGST3(1), OPLAH(4), TXNDC12(2) 12766161 99 80 99 43 45 4 25 7 18 0 0.826 1.000 1.000 390 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(7), FADD(7), IKBKB(11), IL1A(1), IL1R1(1), IRAK1(3), MAP3K1(10), MAP3K7(8), MYD88(1), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TLR4(6), TNF(4), TNFAIP3(7), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF6(1) 14056195 102 80 100 29 59 3 12 5 23 0 0.514 1.000 1.000 391 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(5), BLVRA(5), BLVRB(1), CP(5), CPOX(5), EPRS(12), FECH(2), GUSB(3), HCCS(3), HMOX1(3), HMOX2(2), PPOX(6), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4), UROD(4), UROS(4) 15967504 102 80 102 39 46 4 17 14 21 0 0.927 1.000 1.000 392 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(2), BAX(1), CASP8(14), CYCS(1), FADD(7), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), NFKB1(3), NSMAF(12), RAF1(4), RELA(6), RIPK1(7), SMPD1(4), TNFRSF1A(5), TRADD(2), TRAF2(5) 11874769 103 79 100 29 56 4 11 11 21 0 0.420 1.000 1.000 393 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(4), ACADS(6), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), HMGCL(1), L2HGDH(4), OXCT1(4), PDHA1(5), PDHA2(6), PDHB(1), SDHB(2), SDS(2) 15013646 101 78 100 47 53 6 17 12 13 0 0.984 1.000 1.000 394 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(2), MRPS7(4), RPL10A(3), RPL10L(3), RPL11(2), RPL13(3), RPL19(2), RPL22L1(2), RPL23A(4), RPL24(3), RPL26(4), RPL28(2), RPL29(2), RPL3(1), RPL30(1), RPL31(5), RPL34(2), RPL35A(1), RPL37(1), RPL3L(3), RPL41(1), RPL6(2), RPL7(3), RPL8(2), RPL9(1), RPS10(1), RPS12(3), RPS13(2), RPS16(1), RPS18(6), RPS2(6), RPS20(2), RPS24(1), RPS26(1), RPS29(1), RPS3A(1), RPS4Y1(1), RPS5(1), RPS6(5), RPS7(2), RPS8(2), RPS9(2), RPSA(4) 13137032 101 78 100 41 54 8 25 4 10 0 0.694 1.000 1.000 395 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(5), FOS(4), GRB2(1), HRAS(16), IL3RA(6), JAK2(8), MAP2K1(3), MAPK3(8), PTPN6(2), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5) 10322024 94 78 87 30 40 3 22 10 19 0 0.621 1.000 1.000 396 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(10), ABCC2(12), ABCG2(10), BCHE(9), CES1(4), CES2(3), CYP3A4(9), CYP3A5(4), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3) 13357273 93 78 93 31 44 4 22 11 12 0 0.501 1.000 1.000 397 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(2), CR1(14), CR2(17), FCGR2B(2), HLA-DRA(4), HLA-DRB1(1), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19) 8820248 90 77 89 30 38 5 23 10 14 0 0.597 1.000 1.000 398 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(65), CDC25A(5), CDC25B(2), CDC25C(2), CHEK1(3), MYT1(10), WEE1(10), YWHAH(2) 8041527 99 77 96 22 43 6 14 13 22 1 0.405 1.000 1.000 399 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(3), COASY(8), DPYD(14), DPYS(13), ENPP1(7), ENPP3(5), ILVBL(3), PANK1(3), PANK2(5), PANK3(5), PANK4(7), PPCDC(1), PPCS(9), UPB1(4), VNN1(3) 10082732 94 77 90 41 43 5 20 17 9 0 0.972 1.000 1.000 400 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(12), ARHGEF1(8), GNA12(3), GNA13(12), GNAQ(3), GNB1(7), MYL2(4), MYLK(15), PLCB1(16), PPP1R12B(10), PRKCA(3), ROCK1(8) 12072772 101 77 94 29 56 3 19 15 8 0 0.602 1.000 1.000 401 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(2), CASP2(2), CHUK(7), CRADD(1), IKBKB(11), JUN(4), LTA(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP4K2(5), MAPK14(2), MAPK8(5), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TANK(3), TNF(4), TNFRSF1A(5), TRADD(2), TRAF2(5) 13892378 102 77 99 34 66 4 11 4 17 0 0.667 1.000 1.000 402 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(48), MAP2(15), PPP1CA(8), PPP2CA(2), PRKACB(2), PRKACG(2), PRKAG1(3), PRKAR2A(5), PRKAR2B(5), PRKCE(5) 10617251 95 76 93 19 57 4 13 13 8 0 0.324 1.000 1.000 403 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), DCXR(2), GUSB(3), RPE(1), UGDH(5), UGP2(9), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), XYLB(8) 15913885 102 76 98 29 49 7 12 16 18 0 0.484 1.000 1.000 404 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), P4HB(6), SLC23A1(1), SLC23A2(3), SLC2A1(4), SLC2A3(6) 14352855 85 76 84 40 40 6 22 6 11 0 0.999 1.000 1.000 405 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(7), ACTN2(10), BCAR1(6), CSK(7), CTNNA1(6), CTNNA2(21), CTNNB1(15), PTK2(12), PXN(3), SRC(5), VCL(4) 11096019 96 75 92 23 45 7 24 11 9 0 0.142 1.000 1.000 406 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(5), FUCA1(2), FUCA2(6), GLB1(5), HEXA(3), HEXB(2), LCT(16), MAN2B1(8), MAN2B2(7), MAN2C1(8), MANBA(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5) 11757472 84 75 83 29 44 1 20 10 9 0 0.579 1.000 1.000 407 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(6), AP2M1(2), BAD(2), BTK(5), EEA1(13), GRASP(3), GSK3A(2), GSK3B(4), LYN(5), PDPK1(2), PFKL(1), PFKM(5), PFKP(4), PLCG1(12), PRKCE(5), PRKCZ(4), RAB5A(2), RAC1(4), RPS6KB1(4), VAV2(8) 14514204 96 75 96 32 56 5 10 13 11 1 0.537 1.000 1.000 408 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(5), F2(3), F2R(2), F5(24), F7(8), FGA(17), FGB(5), FGG(7), PROC(2), PROS1(14), SERPINC1(7) 9579714 94 74 92 23 53 4 18 9 10 0 0.279 1.000 1.000 409 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(6), APEX1(1), CREBBP(50), DFFA(6), GZMA(4), GZMB(2), HMGB2(6), NME1(1), PRF1(7), SET(2) 6128157 85 74 82 24 28 2 19 9 26 1 0.503 1.000 1.000 410 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(2), ACP5(8), ACP6(2), ACPP(11), ACPT(4), ALPI(5), ALPL(4), ALPP(3), CMBL(1), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), PON1(6), PON2(2), PON3(3) 10449981 95 73 91 39 41 4 28 6 16 0 0.823 1.000 1.000 411 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(5), CSNK1D(3), DRD1(2), DRD2(5), GRM1(22), PLCB1(16), PPP1CA(8), PPP1R1B(5), PPP2CA(2), PPP3CA(7), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 9327568 98 72 98 26 48 3 23 12 12 0 0.166 1.000 1.000 412 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(5), ALDOB(3), ALDOC(2), DERA(3), FBP1(3), FBP2(2), G6PD(3), GPI(4), H6PD(12), PFKL(1), PFKM(5), PFKP(4), PGD(5), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(3), TALDO1(4), TKT(1), TKTL1(7), TKTL2(5) 14132949 87 72 87 50 37 4 26 11 9 0 0.996 1.000 1.000 413 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), AGPS(5), CHPT1(6), ENPP2(7), ENPP6(3), PAFAH1B1(2), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(4), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLD1(9), PLD2(3), PPAP2A(5), PPAP2B(3), PPAP2C(1) 13463168 89 72 89 45 47 2 11 11 18 0 0.994 1.000 1.000 414 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG5(3), ATG7(4), BECN1(2), GABARAP(3), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNG(2), PIK3C3(11), PIK3R4(11), PRKAA1(9), PRKAA2(7), ULK1(9), ULK2(9), ULK3(1) 12161636 90 72 89 25 54 7 17 7 5 0 0.412 1.000 1.000 415 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), ESRRA(2), HDAC5(6), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), PPARA(1), PPP3CA(7), PPP3CB(6), PPP3CC(4), SLC2A4(4), SYT1(6), YWHAH(2) 11670640 92 72 92 43 48 9 8 12 15 0 0.973 1.000 1.000 416 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(5), ANXA2(2), ANXA3(3), ANXA4(1), ANXA5(4), ANXA6(6), CYP11A1(1), EDN1(2), EDNRA(4), EDNRB(8), HPGD(1), HSD11B2(3), PLA2G4A(1), PRL(3), PTGDR(3), PTGDS(1), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2), PTGIS(2), PTGS1(2), PTGS2(6), S100A6(2), TBXAS1(3) 12021185 84 72 84 37 34 5 32 3 10 0 0.892 1.000 1.000 417 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(5), AGT(3), AGTR1(3), AGTR2(4), CMA1(1), COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), REN(3) 14486384 84 71 83 34 34 6 26 5 13 0 0.996 1.000 1.000 418 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), ACO2(5), CS(3), DLD(7), DLST(1), FH(7), IDH1(9), IDH2(2), IDH3A(3), IDH3B(4), IDH3G(1), MDH1(3), PC(10), PCK1(9), SDHA(9), SDHB(2), SUCLA2(2), SUCLG1(2), SUCLG2(3) 12013419 86 71 86 29 48 2 20 6 10 0 0.575 1.000 1.000 419 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(6), GPLD1(5), PGAP1(5), PIGA(3), PIGB(5), PIGC(4), PIGF(2), PIGG(7), PIGK(4), PIGL(2), PIGM(2), PIGN(1), PIGO(11), PIGQ(5), PIGS(9), PIGT(2), PIGU(5), PIGV(5), PIGW(5), PIGZ(3) 13765901 91 71 90 33 44 2 26 5 14 0 0.465 1.000 1.000 420 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), DDOST(1), DPAGT1(6), DPM1(3), FUT8(7), MAN1A1(3), MAN1B1(9), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(4), MGAT5(7), RPN1(3), RPN2(5), ST6GAL1(4) 11514005 87 71 87 32 41 4 19 15 8 0 0.687 1.000 1.000 421 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(4), HRAS(16), JUN(4), MAP2K1(3), MAPK3(8), MYC(2), NFKB1(3), NFKBIA(6), PLCB1(16), PRKCA(3), RAF1(4), RELA(6), TNF(4) 9053064 82 70 74 26 37 3 24 8 10 0 0.536 1.000 1.000 422 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(10), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), CYP2C19(7), CYP2C9(3), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ECHS1(1), EHHADH(6), ESCO1(3), ESCO2(3), HADHA(4), NAT6(1), PNPLA3(4), SH3GLB1(1), YOD1(1) 18013869 81 69 80 27 36 2 25 4 14 0 0.719 1.000 1.000 423 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ICAM1(7), ITGA4(19), ITGAL(17), ITGAM(13), ITGB1(3), ITGB2(7), SELE(7), SELP(7) 9229964 82 69 81 31 46 3 17 6 10 0 0.816 1.000 1.000 424 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(7), BIRC2(3), BIRC3(3), CASP10(1), CASP3(3), CASP7(5), CASP8(14), CASP9(6), DFFA(6), GZMB(2), PRF1(7), SCAP(9), SREBF1(6), SREBF2(8) 10509336 80 69 80 28 42 4 15 6 13 0 0.743 1.000 1.000 425 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(3), ASNS(1), ASRGL1(3), CA1(3), CA12(2), CA14(1), CA2(2), CA3(1), CA4(2), CA5A(4), CA5B(3), CA6(2), CA7(1), CA8(3), CA9(3), CPS1(13), CTH(5), GLS(3), GLS2(4), GLUD1(6), GLUD2(10), GLUL(3), HAL(6) 12378382 84 68 83 28 38 6 19 8 13 0 0.717 1.000 1.000 426 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(9), IL22(1), IL22RA1(4), IL22RA2(3), JAK1(9), JAK2(8), JAK3(12), SOCS3(1), STAT1(13), STAT3(6), STAT5A(1), STAT5B(5), TYK2(9) 10651332 81 68 80 32 31 4 14 7 25 0 0.844 1.000 1.000 427 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(8), DPYD(14), DPYS(13), ENPP1(7), ENPP3(5), PANK1(3), PANK2(5), PANK3(5), PANK4(7), PPCS(9), UPB1(4) 8119133 84 68 80 35 38 5 16 16 9 0 0.968 1.000 1.000 428 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(1), ALDH18A1(3), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), ARG1(2), ARG2(3), ASL(6), ASS1(2), CPS1(13), GATM(3), MAOA(4), MAOB(2), NAGS(1), ODC1(4), OTC(2), SAT2(3), SMS(1), SRM(3) 17041271 89 67 88 28 43 3 17 12 14 0 0.360 1.000 1.000 429 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(10), EXT2(3), EXTL1(3), EXTL2(4), EXTL3(6), GLCE(5), HS2ST1(3), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), HS6ST2(2), HS6ST3(1), NDST1(2), NDST2(2), NDST3(7), NDST4(13) 11958635 75 67 75 36 38 5 15 7 10 0 0.935 1.000 1.000 430 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(2), ACP5(8), ACP6(2), ACPP(11), ACPT(4), ENPP1(7), ENPP3(5), FLAD1(8), LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), RFK(1), TYR(12) 8779717 85 67 83 28 44 4 19 7 11 0 0.804 1.000 1.000 431 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(7), DUSP1(3), IKBKAP(10), IKBKB(11), LTA(1), MAP3K1(10), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TANK(3), TNFAIP3(7), TNFRSF1B(6), TRAF2(5), TRAF3(2) 13016567 87 67 87 22 53 4 12 3 15 0 0.261 1.000 1.000 432 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(7), IFNG(2), IKBKB(11), IL2(1), JUN(4), MAP3K1(10), MAP3K5(14), MAP4K5(4), MAPK14(2), MAPK8(5), NFKB1(3), NFKBIA(6), RELA(6), TNFRSF9(2), TNFSF9(2), TRAF2(5) 11162507 85 66 83 28 53 2 12 3 15 0 0.783 1.000 1.000 433 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(3), C1R(2), C1S(8), C2(5), C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8), MASP1(8), MASP2(5), MBL2(1) 12378608 85 66 85 29 34 5 26 9 11 0 0.751 1.000 1.000 434 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(8), POLD2(3), POLE(27), POLG(8), POLQ(28) 9755657 74 66 74 18 32 5 15 7 15 0 0.232 1.000 1.000 435 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(6), G6PD(3), GCLC(6), GCLM(2), GGT1(5), GPX2(1), GPX3(1), GPX5(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(4), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), IDH1(9), IDH2(2), MGST1(1), MGST2(1), MGST3(1), PGD(5) 10468473 84 66 84 32 42 3 21 4 14 0 0.614 1.000 1.000 436 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(18), POLR1B(4), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2) 13668577 88 66 87 41 54 4 13 8 9 0 0.989 1.000 1.000 437 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(4), ADSL(4), ADSS(4), AGXT(2), AGXT2(2), ASL(6), ASNS(1), ASPA(2), CAD(15), CRAT(10), DARS(3), DDO(1), GAD1(8), GAD2(6), GOT1(2), GPT(2), GPT2(1), NARS(3), PC(10) 15154734 90 65 89 42 51 3 17 10 9 0 0.961 1.000 1.000 438 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(27), ACACB(20), FASN(12), MCAT(2), OLAH(4), OXSM(8) 9087372 73 65 71 20 40 6 10 10 7 0 0.194 1.000 1.000 439 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(11), ACE2(5), AGT(3), AGTR1(3), AGTR2(4), ANPEP(6), CMA1(1), CPA3(7), CTSA(2), CTSG(4), ENPEP(9), LNPEP(7), MAS1(2), MME(13), NLN(2), REN(3), THOP1(6) 12312028 88 65 86 33 40 3 19 12 14 0 0.723 1.000 1.000 440 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(9), DYRK1B(5), GLI2(16), GLI3(19), GSK3B(4), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), SHH(6), SMO(8), SUFU(2) 9663705 89 65 88 24 31 4 34 5 15 0 0.262 1.000 1.000 441 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(6), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), HEMK1(1), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), WBSCR22(6) 8727356 75 64 70 23 39 2 19 8 7 0 0.376 1.000 1.000 442 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(6), CHAT(4), COMT(3), DBH(4), DDC(8), GAD1(8), GAD2(6), HDC(6), MAOA(4), PAH(11), SLC18A3(5), TH(2), TPH1(3) 8271059 72 63 72 38 25 3 24 8 12 0 0.979 1.000 1.000 443 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(3), C1R(2), C1S(8), C2(5), C3(16), C5(9), C6(9), C7(4), C8A(7), C8B(3), C9(8), MASP1(8) 12095257 82 63 82 28 34 5 25 8 10 0 0.750 1.000 1.000 444 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(5), FUCA1(2), FUCA2(6), GLB1(5), HEXA(3), HEXB(2), LCT(16), MAN2C1(8), MANBA(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5) 9523377 69 63 69 21 35 1 16 9 8 0 0.472 1.000 1.000 445 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), CYB5R3(4), GCK(1), GFPT1(5), GNE(8), GNPDA1(3), GNPDA2(2), HEXA(3), HEXB(2), HK1(15), HK2(11), HK3(8), PGM3(1), RENBP(4), UAP1(5) 9831287 74 61 73 33 37 6 16 5 10 0 0.958 1.000 1.000 446 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(6), CHPT1(6), HEMK1(1), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PCYT1A(1), PCYT1B(2), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), WBSCR22(6) 8144103 69 61 65 21 40 3 13 7 6 0 0.477 1.000 1.000 447 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(27), CPT1A(7), LEP(1), LEPR(8), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKAG1(3) 8483238 66 60 66 21 33 4 9 10 10 0 0.722 1.000 1.000 448 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(5), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), G6PD(3), GPI(4), H6PD(12), PFKM(5), PFKP(4), PGD(5), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(3), TALDO1(4), TKT(1) 11903459 71 60 71 41 30 3 22 9 7 0 0.993 1.000 1.000 449 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(7), ARHGAP5(12), ARHGDIB(1), CASP1(9), CASP10(1), CASP3(3), CASP8(14), CASP9(6), CYCS(1), GZMB(2), JUN(4), PRF1(7) 7525762 67 59 65 22 30 4 12 10 11 0 0.844 1.000 1.000 450 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(8), GALNS(3), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), HGSNAT(4), HPSE(4), HPSE2(4), HYAL2(4), IDS(4), IDUA(1), LCT(16), NAGLU(5), SPAM1(2) 11836355 70 59 70 23 40 3 11 11 5 0 0.453 1.000 1.000 451 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(3), ASNS(1), CA1(3), CA12(2), CA14(1), CA2(2), CA3(1), CA4(2), CA5A(4), CA5B(3), CA6(2), CA7(1), CA8(3), CA9(3), CPS1(13), CTH(5), GLS(3), GLS2(4), GLUD1(6), GLUL(3), HAL(6) 11083784 71 59 70 22 34 4 13 8 12 0 0.567 1.000 1.000 452 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(8), BST1(3), CD38(1), ENPP1(7), ENPP3(5), NADK(3), NADSYN1(6), NMNAT2(1), NMNAT3(1), NNMT(3), NNT(8), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), NUDT12(3), QPRT(4) 12532409 71 58 70 29 42 4 11 4 10 0 0.914 1.000 1.000 453 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(3), PSMA5(5), PSMA6(6), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC2(9), PSMC3(5), PSMD1(7), PSMD11(4), PSMD12(4), PSMD2(6), PSMD6(3) 9340626 71 58 70 24 43 1 13 8 6 0 0.779 1.000 1.000 454 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(2), GOSR1(2), SNAP23(3), SNAP25(4), SNAP29(4), STX10(3), STX11(2), STX12(3), STX16(2), STX18(2), STX19(2), STX2(5), STX3(5), STX4(3), STX5(2), STX6(2), STX7(2), STX8(2), TSNARE1(4), USE1(4), VAMP1(1), VAMP2(1), VAMP3(1), VAMP4(1), VAMP5(1), VAMP8(2), VTI1A(1), VTI1B(6), YKT6(1) 9641982 73 58 73 27 42 3 14 7 7 0 0.772 1.000 1.000 455 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(6), CD3E(2), CD3G(2), CXCR3(3), ETV5(4), IFNG(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), JAK2(8), JUN(4), MAP2K6(1), MAPK14(2), MAPK8(5), STAT4(9), TYK2(9) 10798436 73 58 71 38 36 2 15 6 14 0 0.998 1.000 1.000 456 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(7), CYP51A1(4), DHCR24(3), DHCR7(3), EBP(1), FDPS(6), GGCX(7), GGPS1(1), HMGCR(7), HSD17B7(3), IDI1(2), IDI2(4), LSS(7), MVD(4), NSDHL(3), PMVK(1), SQLE(4), TM7SF2(1), VKORC1(1) 11122542 69 57 69 20 37 3 14 8 7 0 0.272 1.000 1.000 457 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(3), ARG1(2), ARG2(3), ASL(6), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), GATM(3), GLUD1(6), NAGS(1), OAT(1), ODC1(4), OTC(2), PYCR1(3), SMS(1) 10130109 71 57 69 25 39 2 12 9 9 0 0.678 1.000 1.000 458 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), NCK1(2), NCKAP1(12), NTRK1(6), PIR(2), RAC1(4), WASF1(5), WASF2(7), WASF3(5), WASL(2) 8905019 69 56 67 23 36 3 14 5 11 0 0.818 1.000 1.000 459 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(5), F13A1(8), F2(3), F2R(2), FGA(17), FGB(5), FGG(7), PLAT(6), PLG(4), SERPINB2(3), SERPINE1(6) 7811469 66 56 65 19 30 2 16 10 8 0 0.529 1.000 1.000 460 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(3), C1R(2), C1S(8), C2(5), C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8) 10164025 71 55 71 25 29 5 22 5 10 0 0.807 1.000 1.000 461 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), BHMT(1), CBS(2), CTH(5), DNMT1(11), DNMT3A(9), DNMT3B(7), MARS(1), MARS2(5), MAT1A(4), MAT2B(1), MTFMT(2), MTR(7), SRM(3), TAT(5) 11994594 65 55 65 28 32 4 15 8 6 0 0.902 1.000 1.000 462 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(3), CD3E(2), CD3G(2), CD8A(2), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19), THY1(3) 6263281 64 55 64 24 30 3 16 5 10 0 0.564 1.000 1.000 463 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(6), GNAS(12), GNB1(7), PPP2CA(2), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKACB(2), PRKACG(2), PRKAG1(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 8942055 70 54 69 16 32 6 17 8 7 0 0.207 1.000 1.000 464 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(5), B3GNT3(1), B3GNT4(3), B3GNT5(8), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), FUT1(3), FUT2(6), FUT3(3), FUT4(3), FUT5(5), FUT6(2), FUT7(3), FUT9(3), GCNT2(2), ST3GAL6(6), ST8SIA1(2) 9371057 70 54 68 29 36 0 17 10 7 0 0.747 1.000 1.000 465 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(6), B4GALNT1(2), GLB1(5), HEXA(3), HEXB(2), LCT(16), SLC33A1(3), ST3GAL1(1), ST3GAL2(3), ST3GAL5(5), ST6GALNAC3(5), ST6GALNAC4(2), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(2) 9619087 63 54 63 31 33 2 13 11 4 0 0.938 1.000 1.000 466 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(5), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), GOT1(2), GPT(2), GPT2(1), MDH1(3), ME1(5), ME3(6), PGK1(2), PKLR(8), RPE(1), RPIA(3), TKT(1), TKTL1(7), TKTL2(5), TPI1(1) 11714053 62 54 62 31 29 1 20 8 4 0 0.947 1.000 1.000 467 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ICAM1(7), ITGA4(19), ITGAL(17), ITGB1(3), ITGB2(7), SELE(7) 7028740 62 54 61 21 34 1 13 5 9 0 0.677 1.000 1.000 468 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(7), BAK1(2), BAX(1), BCL2L1(4), BID(2), BIK(1), BIRC2(3), BIRC3(3), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), DFFA(6), DIABLO(3) 7837497 62 54 61 23 33 4 12 1 12 0 0.930 1.000 1.000 469 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(5), DAB1(5), FYN(7), LRP8(6), RELN(36), VLDLR(6) 8197876 68 54 68 21 33 4 17 9 5 0 0.695 1.000 1.000 470 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(3), CD3E(2), CD3G(2), CD4(3), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19), THY1(3) 6570969 65 54 65 25 31 2 16 6 10 0 0.608 1.000 1.000 471 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(4), ARFGAP3(4), ARFGEF2(18), CLTA(3), CLTB(1), COPA(12), GBF1(16), GPLD1(5), KDELR2(1), KDELR3(1) 9493504 65 53 65 22 41 6 7 1 10 0 0.578 1.000 1.000 472 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(7), DUSP1(3), IKBKAP(10), IKBKB(11), MAP3K1(10), NFKB1(3), NFKBIA(6), RELA(6), TNFAIP3(7), TRAF3(2), TRAF6(1) 10519839 66 53 66 18 41 3 7 1 14 0 0.469 1.000 1.000 473 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(13), EGF(17), EGFR(7), HGS(11), RAB5A(2), TF(4), TFRC(9) 7521093 63 52 62 22 35 4 11 6 7 0 0.887 1.000 1.000 474 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(4), CLOCK(8), CRY1(3), CRY2(4), CSNK1D(3), CSNK1E(3), NPAS2(7), NR1D1(3), PER1(6), PER2(6), PER3(12) 9864281 59 52 59 25 28 1 16 4 10 0 0.947 1.000 1.000 475 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(2), CCR1(1), CCR3(3), CCR4(3), CCR5(6), CCR7(3), CD28(3), CD4(3), CXCR3(3), CXCR4(4), IFNG(2), IFNGR1(1), IFNGR2(6), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), IL2(1), IL4R(6), IL5(1), TGFB1(2), TGFB3(1) 11623419 67 52 67 33 26 2 16 13 10 0 0.942 1.000 1.000 476 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(6), CD2(2), CD33(6), CD5(3), CD7(3), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL5(1), ITGAX(3), TLR2(3), TLR4(6), TLR7(9), TLR9(6) 10838493 57 51 57 33 24 5 14 6 8 0 0.983 1.000 1.000 477 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL5(1), JUNB(5), MAF(3), MAP2K3(6), MAPK14(2), NFATC1(13), NFATC2(13), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 7020066 71 51 71 29 25 5 24 7 10 0 0.809 1.000 1.000 478 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), ACO2(5), AFMID(4), CS(3), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(9), MTHFD2(6) 7826098 58 51 57 19 27 3 19 2 7 0 0.528 1.000 1.000 479 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(3), ATIC(2), FTCD(3), GART(7), MTFMT(2), MTHFD1(7), MTHFD1L(9), MTHFD2(6), MTHFR(4), MTHFS(2), MTR(7), SHMT1(3), SHMT2(2), TYMS(3) 11036760 63 51 63 26 30 4 14 6 9 0 0.887 1.000 1.000 480 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), DCXR(2), GUSB(3), RPE(1), UCHL1(3), UCHL3(3), UGDH(5), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4) 10241286 61 50 61 22 27 3 10 11 10 0 0.796 1.000 1.000 481 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(5), ESR2(3), ITPKA(4), PDE1A(8), PDE1B(4), PLCB1(16), PLCB2(6), PRL(3), TRH(6) 6429814 55 50 54 19 24 2 16 8 5 0 0.671 1.000 1.000 482 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(2), EPHB1(14), FYN(7), ITGA1(7), ITGB1(3), L1CAM(8), LYN(5), RAP1B(2), SELP(7) 9223404 59 49 59 18 26 3 17 6 7 0 0.563 1.000 1.000 483 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(5), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ESCO1(3), ESCO2(3), NAT6(1), PNPLA3(4), SH3GLB1(1) 14554566 61 49 60 17 28 2 18 5 8 0 0.496 1.000 1.000 484 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(1), IL2RG(5), IL4R(6), IRS1(9), JAK1(9), JAK3(12), RPS6KB1(4), SHC1(8), STAT6(9) 8545155 66 49 66 28 30 1 16 9 9 1 0.879 1.000 1.000 485 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(6), CD2(2), CD3E(2), CD3G(2), CD4(3), CXCR3(3), IFNG(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), JAK2(8), STAT4(9), TYK2(9) 8489089 58 49 58 28 22 3 15 6 12 0 0.975 1.000 1.000 486 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(3), ATIC(2), ATP6V0C(2), GART(7), MTHFD1(7), MTHFD1L(9), MTHFD2(6), MTHFR(4), MTHFS(2), MTR(7), SHMT1(3), SHMT2(2), TYMS(3) 10448764 60 49 60 26 31 3 14 4 8 0 0.906 1.000 1.000 487 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(4), NR3C1(6), PPARG(13), RXRA(25), TNF(4) 3385167 52 49 36 18 29 2 9 3 9 0 0.643 1.000 1.000 488 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM2(2), CCL2(1), CCR5(6), CXCR4(4), FOS(4), GNAQ(3), JUN(4), MAPK14(2), MAPK8(5), PLCG1(12), PRKCA(3), PTK2B(6), SYT1(6) 8024865 60 48 58 24 27 4 9 10 10 0 0.836 1.000 1.000 489 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3E(2), CD3G(2), GZMB(2), HLA-A(7), ICAM1(7), ITGAL(17), ITGB2(7), PRF1(7) 5075094 54 48 53 22 20 0 16 7 11 0 0.651 1.000 1.000 490 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), ACO2(5), CS(3), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(9), MTHFD2(6) 7473972 54 48 53 19 25 2 19 2 6 0 0.644 1.000 1.000 491 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT2(5), B3GAT3(3), B4GALT7(1), CHPF(4), CHST11(2), CHST12(3), CHST14(3), CHST7(2), CHSY1(9), DSE(6), UST(4), XYLT1(6), XYLT2(6) 7961671 55 48 52 30 29 2 13 5 6 0 0.936 1.000 1.000 492 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(5), ACAT2(1), ACOT11(10), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ECHS1(1), EHHADH(6), ESCO1(3), ESCO2(3), FN3K(2), GCDH(5), HADHA(4), NAT6(1), PNPLA3(4), SH3GLB1(1), YOD1(1) 15167842 62 48 61 24 33 1 15 3 10 0 0.925 1.000 1.000 493 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), BHMT(1), CBS(2), CTH(5), DNMT1(11), DNMT3A(9), DNMT3B(7), MARS(1), MARS2(5), MAT1A(4), MAT2B(1), MTR(7) 10102031 55 48 55 23 27 3 14 7 4 0 0.847 1.000 1.000 494 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(7), ITGAL(17), ITGAM(13), ITGB2(7), SELE(7) 5987153 53 48 52 23 29 1 14 3 6 0 0.772 1.000 1.000 495 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(9), JAK2(8), JAK3(12), PIAS1(3), PIAS3(5), PTPRU(7), REG1A(8), SOAT1(5) 7938106 58 48 58 19 25 2 18 3 10 0 0.544 1.000 1.000 496 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(5), EGR1(7), HRAS(16), KLK2(1), MAP2K1(3), MAP2K2(5), MAPK3(8), NGFR(4), RAF1(4) 4755257 56 47 50 23 17 3 22 7 7 0 0.761 1.000 1.000 497 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(8), GALNS(3), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), IDS(4), IDUA(1), LCT(16), NAGLU(5) 8306878 52 47 52 15 31 3 8 7 3 0 0.304 1.000 1.000 498 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), AOC2(5), AOC3(6), CES1(4), DDHD1(11), ESCO1(3), ESCO2(3), LIPA(3), NAT6(1), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(5), SH3GLB1(1) 14716988 53 47 53 13 29 4 9 7 4 0 0.371 1.000 1.000 499 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(9), JAK2(8), JAK3(12), MAPK3(8), STAT3(6), TYK2(9) 6769111 52 47 52 24 20 4 12 3 13 0 0.937 1.000 1.000 500 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(5), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), GOT1(2), GPT(2), GPT2(1), MDH1(3), ME1(5), ME2(1), ME3(6), PGK1(2), PKLR(8), RPE(1), RPIA(3), TKT(1), TPI1(1) 10461276 51 46 51 26 25 1 16 6 3 0 0.947 1.000 1.000 501 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(15), KHK(1), LCT(16), MPI(7), PGM1(3), PYGL(4), PYGM(13), TPI1(1), TREH(1) 7756453 61 46 60 26 32 3 16 5 5 0 0.732 1.000 1.000 502 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(10), ACO1(4), ACO2(5), ACSS1(7), ACSS2(2), FH(7), IDH1(9), IDH2(2), MDH1(3), SUCLA2(2) 7760514 51 46 51 31 26 3 6 9 7 0 0.991 1.000 1.000 503 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(16), ABCB11(4), ABCB4(11), ABCC1(10), ABCC3(15), GSTP1(2) 8339112 58 46 57 20 34 4 10 5 5 0 0.361 1.000 1.000 504 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(2), ACP5(8), ACPP(11), ACPT(4), ENPP1(7), ENPP3(5), FLAD1(8), RFK(1), TYR(12) 5664987 59 46 57 23 29 3 15 3 9 0 0.897 1.000 1.000 505 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(1), JAK1(9), PTPRU(7), REG1A(8), STAT1(13), STAT2(4), TYK2(9) 7270570 53 46 52 21 17 3 17 4 11 1 0.681 1.000 1.000 506 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8) 7318348 53 45 53 19 24 5 16 4 4 0 0.851 1.000 1.000 507 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(1), EHHADH(6), HADH(5), HADHA(4), HSD17B10(1), HSD17B4(5), NTAN1(2), SIRT1(9), SIRT2(2), SIRT5(3), SIRT7(4), VNN2(4) 6900744 48 45 46 15 32 3 3 3 7 0 0.753 1.000 1.000 508 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(3), FH(7), IDH2(2), MDH1(3), OGDH(21), SDHA(9), SUCLA2(2) 5497154 52 45 49 16 25 3 11 7 6 0 0.451 1.000 1.000 509 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(7), DLL1(9), FURIN(9), NOTCH1(17), PSEN1(8) 5199560 50 45 48 16 22 3 15 1 7 2 0.461 1.000 1.000 510 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(7), BRAF(9), CAMP(1), CREB5(10), RAF1(4), SNX13(5), SRC(5), TERF2IP(4) 6451866 49 45 49 16 21 3 7 11 7 0 0.754 1.000 1.000 511 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(3), CD86(6), HLA-DRA(4), HLA-DRB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), IL2(1), IL2RA(1), IL4R(6) 7382887 47 45 47 19 18 2 13 8 6 0 0.855 1.000 1.000 512 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 FOS(4), JUN(4), KEAP1(9), MAFG(1), MAFK(1), MAPK14(2), MAPK8(5), NFE2L2(25), PRKCA(3) 5084772 54 44 43 19 31 1 10 6 6 0 0.795 1.000 1.000 513 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(5), CTSD(6), ESR1(5), GREB1(16), HSPB1(1), HSPB2(4), MTA1(5), MTA3(1), PDZK1(2), TUBA8(2) 6210655 47 44 46 16 15 2 23 2 5 0 0.443 1.000 1.000 514 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(8), CD38(1), ENPP1(7), ENPP3(5), NADSYN1(6), NMNAT2(1), NNMT(3), NNT(8), NT5C(1), NT5E(6), QPRT(4) 8467349 50 44 49 19 30 3 7 4 6 0 0.818 1.000 1.000 515 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(5), GALNT10(2), GALNT2(7), GALNT3(5), GALNT4(3), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GCNT1(5), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), WBSCR17(9) 8417000 59 44 59 20 28 5 15 5 6 0 0.615 1.000 1.000 516 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(16), MMP14(4), MMP2(7), MMP9(6), RECK(8), TIMP2(4), TIMP4(3) 4372162 48 44 42 21 20 3 20 3 2 0 0.853 1.000 1.000 517 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(2), FOS(4), JUN(4), MAPK3(8), OPRK1(4), POLR2A(13), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 7475395 55 43 53 20 28 3 13 3 8 0 0.687 1.000 1.000 518 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(14), ANKRD1(1), CYR61(6), DUSP14(4), EIF4E(2), EIF4EBP1(1), HBEGF(1), IFNG(2), IFRD1(6), IL1A(1), IL1R1(1), JUND(2), MYOG(2), NR4A3(4), WDR1(3) 6208349 50 43 47 16 31 3 6 3 7 0 0.646 1.000 1.000 519 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(1), ACADS(6), ACADVL(2), ACSL1(3), ACSL3(2), ACSL4(2), CPT1A(7), CPT2(5), EHHADH(6), HADHA(4), SCP2(4), SLC25A20(3) 9805244 47 43 47 16 25 1 10 6 5 0 0.727 1.000 1.000 520 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(15), HK2(11), HK3(8), IMPA1(1), IMPA2(4), ISYNA1(2), PGM1(3), PGM3(1), TGDS(3) 6757795 49 42 48 25 21 3 12 3 10 0 0.963 1.000 1.000 521 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(7), CASP3(3), CASP9(6), CYCS(1), DAXX(9), FAS(1), FASLG(1), HSPB1(1), HSPB2(4), IL1A(1), MAPKAPK2(1), MAPKAPK3(3), TNF(4) 6605523 46 42 46 25 21 5 12 1 7 0 0.991 1.000 1.000 522 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), SDS(2) 7052603 46 42 45 19 24 2 8 4 8 0 0.795 1.000 1.000 523 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(3), CD3E(2), CD3G(2), IFNG(2), IL2(1), IL2RA(1), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8), TGFBR3(10), TOB1(5), TOB2(2) 6161601 46 42 46 20 21 3 9 2 10 1 0.922 1.000 1.000 524 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(2), UBE2A(2), UBE2B(2), UBE2C(3), UBE2D1(2), UBE2D2(1), UBE2D3(3), UBE2E3(1), UBE2H(3), UBE2I(1), UBE2J1(5), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(3), UBE2N(4), UBE2S(2), UBE3A(10) 6125902 50 42 48 18 27 5 5 8 5 0 0.849 1.000 1.000 525 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(7), CDO1(2), CTH(5), GOT1(2), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), MPST(1), SDS(2), SULT1B1(5), SULT1C2(4), SULT1C4(4) 7304186 46 41 45 16 23 5 9 2 7 0 0.712 1.000 1.000 526 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(4), ACOX1(6), ACOX3(7), ELOVL2(2), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(2), FASN(12), HADHA(4), HSD17B12(3), SCD(2) 8249688 47 41 47 21 20 3 10 5 9 0 0.777 1.000 1.000 527 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(6), ADRB2(3), GNAS(12), PLCE1(10), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RAP2B(1) 8621275 52 41 52 20 22 2 15 5 8 0 0.830 1.000 1.000 528 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(4), CNR2(6), DNMT1(11), MTNR1A(4), MTNR1B(1), PTAFR(1), PTGDR(3), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2) 6441056 51 41 51 25 22 4 17 2 6 0 0.695 1.000 1.000 529 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CAMKK1(3), CAMKK2(5), SYT1(6) 6669495 50 40 50 30 27 4 4 5 10 0 0.997 1.000 1.000 530 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), NAT1(4), NAT2(1), XDH(11) 4683662 42 40 40 15 24 2 8 5 3 0 0.432 1.000 1.000 531 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(6), CAPN1(5), CAPNS2(1), CDK5(3), CDK5R1(5), CSNK1A1(6), CSNK1D(3), GSK3B(4), MAPT(10), PPP2CA(2) 5334023 45 39 45 28 22 1 10 3 9 0 0.999 1.000 1.000 532 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(11), AGT(3), AGTR1(3), AGTR2(4), BDKRB2(2), KNG1(5), NOS3(11), REN(3) 5659014 42 38 41 20 19 2 12 4 5 0 0.803 1.000 1.000 533 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(3), CASP7(5), DFFA(6), GZMB(2), HMGB1(4), HMGB2(6), TOP2A(13), TOP2B(5) 5161152 44 38 44 13 28 2 5 5 4 0 0.836 1.000 1.000 534 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(5), ALAS1(12), ALAS2(3), CPOX(5), FECH(2), PPOX(6), UROD(4), UROS(4) 4349525 41 38 41 19 20 3 4 6 8 0 0.968 1.000 1.000 535 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(5), B3GNT7(1), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), CHST1(2), CHST2(1), CHST4(3), CHST6(1), FUT8(7), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1) 7249622 43 38 42 31 21 0 9 9 4 0 0.997 1.000 1.000 536 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNAR2(5), IFNB1(1), JAK1(9), STAT1(13), STAT2(4), TYK2(9) 6297014 44 38 43 16 15 3 9 3 13 1 0.656 1.000 1.000 537 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15(5), ALOX15B(3), ALOX5(4), DPEP1(2), GGT1(5), LTA4H(3), PLA2G2A(2), PLA2G6(4), PTGDS(1), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3) 8658093 44 37 44 24 19 2 10 5 8 0 0.915 1.000 1.000 538 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(7), ERBB4(11), NRG2(2), NRG3(8), PRKCA(3), PSEN1(8) 5238652 39 37 39 11 15 2 10 4 8 0 0.581 1.000 1.000 539 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(2), GSS(7), NFKB1(3), NOX1(4), RELA(6), SOD1(4), TNF(4), XDH(11) 5747866 41 37 41 12 23 0 10 1 7 0 0.283 1.000 1.000 540 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), ADSS(4), HPRT1(1), IMPDH1(1), MTHFD2(6), NME2(1), OAZ1(4), POLD1(8), POLG(8), PRPS2(1), RRM1(4), SRM(3) 7223915 45 37 45 13 20 6 13 1 5 0 0.485 1.000 1.000 541 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5) 7771103 46 37 46 26 29 2 5 6 4 0 0.993 1.000 1.000 542 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(15), HK2(11), HK3(8), IMPA1(1), PGM1(3), PGM3(1), TGDS(3) 5940854 43 37 42 22 19 3 10 2 9 0 0.962 1.000 1.000 543 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(4), AASDH(13), AASS(11), KARS(10) 4073260 38 36 38 12 23 3 7 3 2 0 0.808 1.000 1.000 544 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(3), PSMA5(5), PSMA6(6), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMB8(4), PSMB9(2) 5099611 40 36 39 14 24 1 8 5 2 0 0.756 1.000 1.000 545 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(9), HSD17B1(1), HSD17B2(6), HSD17B3(1), HSD17B4(5), HSD17B7(3), HSD3B1(5), HSD3B2(5) 4720980 38 36 38 15 22 2 5 5 4 0 0.775 1.000 1.000 546 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(2), GPR161(7), GPR171(3), GPR18(3), GPR39(4), GPR45(4), GPR65(3), GPR68(4), GPR75(9) 5743118 39 35 38 18 18 3 9 5 4 0 0.544 1.000 1.000 547 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(6), ACOX3(7), FADS2(2), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4) 5864885 39 35 39 23 17 0 9 4 9 0 0.985 1.000 1.000 548 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(3), CSF1(4), CSF3(1), HLA-DRA(4), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL15(1), IL1A(1), IL2(1), IL5(1), IL6(4), IL7(1), LTA(1), TGFB1(2), TGFB3(1), TNF(4) 7668150 39 35 39 16 22 0 10 3 4 0 0.608 1.000 1.000 549 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(5), CAMK1G(4), HDAC9(8), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MYOD1(1), YWHAH(2) 4358814 38 35 38 15 17 5 5 4 7 0 0.851 1.000 1.000 550 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(7), MAPK14(2), MAPK8(5), NFKB1(3), RELA(6), TNFRSF13B(1), TNFRSF13C(3), TNFRSF17(2), TNFSF13(2), TNFSF13B(5), TRAF2(5), TRAF3(2), TRAF5(1), TRAF6(1) 8408660 45 35 45 14 30 1 7 2 5 0 0.584 1.000 1.000 551 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(12), GNB1(7), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3) 5599472 46 34 45 12 21 5 11 5 4 0 0.431 1.000 1.000 552 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(5), ALAS1(12), ALAS2(3), CPO(3), FECH(2), GATA1(6), HBB(1), UROD(4), UROS(4) 4456460 40 34 40 15 19 4 4 4 9 0 0.838 1.000 1.000 553 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(10), CS(3), MDH1(3), ME1(5), PC(10), PDHA1(5), SLC25A1(1), SLC25A11(2) 5386137 39 34 39 25 21 0 11 4 3 0 0.983 1.000 1.000 554 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(6), CREM(2), FHL5(4), FSHB(1), FSHR(5), GNAS(12), XPO1(7) 5604723 37 33 37 15 20 0 7 4 6 0 0.895 1.000 1.000 555 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(3), NFKB1(3), NFKBIA(6), PLCB1(16), PRKCA(3), RELA(6) 4778112 37 33 37 11 24 1 8 3 1 0 0.559 1.000 1.000 556 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(7), BAD(2), BAK1(2), BAX(1), BCL10(3), BCL2L1(4), BCL2L11(3), BID(2), CASP9(6), CES1(4) 6211003 34 33 33 10 8 5 9 2 10 0 0.830 1.000 1.000 557 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7) 4626946 33 32 32 13 15 1 8 4 5 0 0.677 1.000 1.000 558 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(20), GNA12(3), PRKACB(2), PRKACG(2), PRKAG1(3), PRKAR2A(5), PRKAR2B(5) 5886779 40 32 40 11 20 1 8 5 6 0 0.584 1.000 1.000 559 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7) 4626946 33 32 32 13 15 1 8 4 5 0 0.677 1.000 1.000 560 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(3), FUT1(3), FUT2(6), FUT9(3), GLA(3), HEXA(3), HEXB(2), NAGA(3), ST3GAL1(1), ST3GAL2(3), ST8SIA1(2) 6224947 34 32 34 18 15 0 12 3 4 0 0.926 1.000 1.000 561 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(2), ENO3(4), FARS2(1), GOT1(2), PAH(11), TAT(5), YARS(5) 4853154 33 32 33 12 11 1 5 7 9 0 0.692 1.000 1.000 562 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(5), CCNH(4), CDC25A(5), CDC25B(2), CDC25C(2), CDK7(6), MNAT1(4), SHH(6), XPO1(7) 5052462 41 32 40 15 28 2 5 1 5 0 0.893 1.000 1.000 563 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), CBS(2), CTH(5), GGT1(5), MARS(1), MARS2(5), MAT1A(4), MAT2B(1), PAPSS1(4), PAPSS2(2), SCLY(2), SEPHS1(2) 7181033 35 32 35 20 17 2 11 1 4 0 0.965 1.000 1.000 564 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(6), JAK1(9), JAK2(8), TYK2(9) 6104608 34 32 34 16 9 2 9 6 8 0 0.957 1.000 1.000 565 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(6), JAK1(9), JAK2(8), TYK2(9) 6104608 34 32 34 16 9 2 9 6 8 0 0.957 1.000 1.000 566 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(4), NDUFA5(1), NDUFA8(4), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFS1(5), NDUFS2(3), NDUFV1(4), NDUFV2(6) 4039204 37 32 35 12 24 0 7 2 4 0 0.763 1.000 1.000 567 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(6), CHAT(4), CHKA(5), PCYT1A(1), PDHA1(5), PDHA2(6), PEMT(1), SLC18A3(5) 3996273 33 31 33 21 11 2 13 4 3 0 0.984 1.000 1.000 568 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(7), CYCS(1), GPD2(9), NDUFA1(1), SDHA(9), SDHB(2), SDHC(2), SDHD(3), UQCRC1(2) 3866268 36 31 36 13 17 2 12 2 3 0 0.815 1.000 1.000 569 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(3), GPI(4), HK1(15), PFKL(1), PGAM1(1), PGK1(2), PKLR(8), TPI1(1) 5368723 38 31 38 21 17 1 12 4 4 0 0.936 1.000 1.000 570 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), ACO2(5), FH(7), IDH1(9), IDH2(2), MDH1(3), SDHB(2), SUCLA2(2) 5199412 34 31 34 14 19 2 5 5 3 0 0.820 1.000 1.000 571 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(2), CD4(3), FYN(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PTPRC(19), ZAP70(2) 5270758 42 31 42 21 18 0 13 7 4 0 0.962 1.000 1.000 572 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 CCL3(2), CSF3(1), EPO(2), FLT3(10), IGF1(2), IL1A(1), IL6(4), KITLG(5), TGFB1(2), TGFB3(1) 4762675 30 30 30 11 18 1 7 0 4 0 0.635 1.000 1.000 573 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(3), FUT2(6), FUT9(3), GLA(3), HEXA(3), HEXB(2), NAGA(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), ST8SIA1(2) 5858469 31 30 31 18 12 0 11 3 5 0 0.958 1.000 1.000 574 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(5), ACAT2(1), BDH2(3), HMGCL(1), HMGCS1(9), HMGCS2(7), OXCT1(4), OXCT2(2) 4204082 32 30 32 12 16 2 6 5 3 0 0.827 1.000 1.000 575 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(7), SRP19(1), SRP54(2), SRP68(12), SRP72(6), SRP9(1), SRPR(3) 4424152 32 29 32 10 19 1 2 5 5 0 0.686 1.000 1.000 576 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(6), GNAS(12), GNB1(7), PRKACA(2), PRKAR1A(3) 3861208 30 28 29 14 15 3 7 2 3 0 0.887 1.000 1.000 577 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(6), CKM(5), EIF4E(2), FBL(2), GPT(2), LDHB(2), LDHC(4), MAPK14(2), NCL(3) 5229814 28 28 28 15 18 2 6 1 1 0 0.962 1.000 1.000 578 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(5), CDC25A(5), CDC25B(2), CDC25C(2), CSK(7), GRB2(1), PRKCA(3), PTPRA(2), SRC(5) 5374586 32 28 32 26 20 2 8 2 0 0 1.000 1.000 1.000 579 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(3), CD36(2), FOS(4), FYN(7), JUN(4), MAPK14(2), THBS1(8) 4319310 30 28 28 13 14 0 9 4 3 0 0.911 1.000 1.000 580 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(4), CLOCK(8), CRY1(3), CRY2(4), CSNK1E(3), PER1(6) 4876676 28 27 28 10 11 0 9 2 6 0 0.823 1.000 1.000 581 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), HSD3B7(2), PON1(6), PON2(2), PON3(3), RDH12(2), RDH13(1) 5235485 32 27 30 18 11 0 13 2 6 0 0.949 1.000 1.000 582 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), B4GALT7(1), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), XYLT1(6), XYLT2(6) 3691193 26 26 24 17 13 2 6 1 4 0 0.903 1.000 1.000 583 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), B4GALT7(1), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), XYLT1(6), XYLT2(6) 3691193 26 26 24 17 13 2 6 1 4 0 0.903 1.000 1.000 584 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(1), HADH(5), HADHA(4), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(6), PPT1(1), PPT2(4) 4925239 33 26 31 10 24 3 2 1 3 0 0.506 1.000 1.000 585 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), UGDH(5) 4923620 27 25 27 13 10 2 5 5 5 0 0.874 1.000 1.000 586 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(2), CHST12(3), PAPSS1(4), PAPSS2(2), SULT1A1(3), SULT1A2(1), SULT1E1(1), SULT2A1(4), SULT2B1(2), SUOX(3) 5384806 27 25 26 20 16 2 4 4 1 0 0.997 1.000 1.000 587 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), FUT8(7), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1) 4571457 28 25 28 13 14 0 6 5 3 0 0.834 1.000 1.000 588 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(4), IL1B(3), MST1R(16), TNF(4) 3802040 28 25 28 18 11 1 7 2 7 0 0.971 1.000 1.000 589 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(4), AASS(11), KARS(10) 2758501 25 24 25 11 18 1 4 1 1 0 0.957 1.000 1.000 590 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(3), CDO1(2), CSAD(3), GAD1(8), GAD2(6), GGT1(5) 3329217 27 24 27 14 11 2 8 2 4 0 0.932 1.000 1.000 591 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(3), CD3E(2), CD3G(2), CD4(3), CD58(1), CD8A(2), CSF3(1), IL6(4), KITLG(5) 3612454 25 22 25 13 11 2 7 1 4 0 0.920 1.000 1.000 592 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(8), HDC(6), TH(2), TPH1(3) 3446149 23 22 23 12 11 1 6 1 4 0 0.913 1.000 1.000 593 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(6), PARK2(4), SNCA(1), SNCAIP(7), UBE2E2(1), UBE2F(1), UBE2L3(2), UBE2L6(2) 3754340 24 22 24 10 11 3 3 3 4 0 0.877 1.000 1.000 594 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(5), ACAT2(1), ECHS1(1), EHHADH(6), GCDH(5), HADHA(4), SDHB(2), SDS(2) 4551112 26 21 26 13 17 1 2 1 5 0 0.955 1.000 1.000 595 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ESCO1(3), ESCO2(3), NAT6(1), PNPLA3(4), SH3GLB1(1) 9685560 27 21 26 12 10 1 11 2 3 0 0.948 1.000 1.000 596 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(12), PRKCA(3), PTK2B(6) 3907826 22 20 22 14 11 2 5 2 2 0 0.944 1.000 1.000 597 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(3), CASP8(14), CFL1(1), CFLAR(2) 2251441 20 20 20 10 10 1 2 2 5 0 0.907 1.000 1.000 598 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(4), NR1I3(4), PTGS1(2), PTGS2(6) 3136003 20 19 20 10 9 3 4 2 2 0 0.787 1.000 1.000 599 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(5), ALPL(4), ALPP(3), FPGS(4), GCH1(1), GGH(3) 3683789 20 19 20 12 10 0 8 1 1 0 0.875 1.000 1.000 600 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT1(3), FUT2(6), FUT9(3), GCNT2(2), ST8SIA1(2) 3559098 19 18 19 13 8 0 7 3 1 0 0.962 1.000 1.000 601 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(3), GRIA2(7), JUND(2), PPP1R1B(5) 2161565 20 18 20 13 11 0 4 3 2 0 0.988 1.000 1.000 602 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(6), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), ST3GAL5(5), ST6GALNAC4(2), ST8SIA1(2) 3277672 20 18 20 10 7 0 3 7 3 0 0.816 1.000 1.000 603 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(4), COQ5(5), COQ6(7), NDUFA12(1), NDUFA13(1) 2310212 20 18 20 10 11 3 2 1 3 0 0.946 1.000 1.000 604 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(3), BMPR1B(4), BMPR2(9) 3642933 21 18 21 11 11 1 2 1 6 0 0.971 1.000 1.000 605 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(3), CD8A(2), CSF1(4), CSF3(1), EPO(2), IL2(1), IL5(1), IL6(4), IL7(1) 3489735 19 18 19 10 11 1 5 2 0 0 0.834 1.000 1.000 606 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(3), GBA(4), GGT1(5), SHMT1(3), SHMT2(2) 3137199 17 16 17 13 5 1 7 1 3 0 0.987 1.000 1.000 607 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), CBS(2), CTH(5), MUT(9) 2855059 17 16 17 5 11 1 2 3 0 0 0.620 1.000 1.000 608 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(4), PAPSS2(2), SULT1A2(1), SULT1E1(1), SULT2A1(4), SUOX(3) 3581651 17 16 17 12 9 1 4 2 1 0 0.994 1.000 1.000 609 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(6), ALDH1A2(6) 2281033 12 12 11 6 7 0 3 2 0 0 0.836 1.000 1.000 610 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(5), PRKCA(3), TGM2(2) 2861448 11 11 11 12 5 0 3 2 1 0 0.997 1.000 1.000 611 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(6), CD28(3), CD3E(2), CD3G(2), CD4(3) 1881739 16 11 16 10 5 1 4 4 2 0 0.934 1.000 1.000 612 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(2), GGT1(5), SHMT1(3), SHMT2(2) 2375220 12 10 12 10 4 0 5 0 3 0 0.975 1.000 1.000 613 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), EPHX2(4), HSD3B7(2), RDH12(2), RDH13(1) 2776382 10 9 10 12 5 2 1 1 1 0 0.997 1.000 1.000 614 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(2) 1049299 5 5 5 5 2 2 1 0 0 0 0.975 1.000 1.000 615 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 960891 1 1 1 2 1 0 0 0 0 0 0.982 1.000 1.000 616 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 421699 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000