rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(8)	1005449	8	8	8	0	3	0	3	0	2	0	0.130	0.467	1.000
2	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(7), CYP2C9(3)	1188571	10	10	10	2	3	0	6	0	1	0	0.372	0.561	1.000
3	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), NFS1(5), THTPA(2), TPK1(4)	3725882	35	32	35	4	21	0	5	5	4	0	0.0696	0.742	1.000
4	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4)	3308380	25	24	25	3	11	1	6	2	5	0	0.0653	0.748	1.000
5	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(3), FMOD(3), KERA(7), LUM(2)	2112006	17	16	17	2	9	0	5	2	1	0	0.0853	0.773	1.000
6	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	299386	1	1	1	0	1	0	0	0	0	0	0.748	0.780	1.000
7	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(9), IFNG(2), IL12A(1), IL12B(3), IL2(1)	1737741	16	16	16	3	9	0	4	1	2	0	0.326	0.815	1.000
8	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(8), GOT1(2), TAT(5), TYR(12)	2741084	27	23	27	4	12	1	9	1	4	0	0.0860	0.819	1.000
9	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(3), CD4(3), HLA-DRA(4), HLA-DRB1(1)	1383675	11	11	11	3	5	1	3	2	0	0	0.401	0.843	1.000
10	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(3), LIPT1(1)	897135	4	4	4	0	3	0	1	0	0	0	0.434	0.860	1.000
11	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(12), SPCS3(1)	1788894	15	15	15	4	7	1	4	1	2	0	0.394	0.872	1.000
12	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(3), UGDH(5), UGP2(9), UXS1(3)	2849723	21	19	19	3	8	3	2	3	5	0	0.207	0.881	1.000
13	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(3), GNB1(7), HTR2C(1), PLCB1(16), TUB(4)	4164702	33	30	32	4	18	2	9	3	1	0	0.0266	0.882	1.000
14	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(4), BIRC3(3), CASP8(14), FADD(7), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5)	4817772	57	49	55	9	36	1	7	4	9	0	0.0280	0.929	1.000
15	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(6), IDI1(2), SQLE(4)	1843674	12	12	12	2	6	0	3	2	1	0	0.313	0.963	1.000
16	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(2)	664914	4	3	4	3	1	0	2	0	1	0	0.943	0.972	1.000
17	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(8), PDXK(4), PDXP(2), PNPO(2), PSAT1(6)	2831492	22	19	22	9	6	1	2	3	10	0	0.855	0.977	1.000
18	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(5), AOC3(6), CES1(4), ESD(3)	3501402	18	18	18	3	7	0	5	4	2	0	0.191	0.984	1.000
19	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), TAT(5)	1526099	7	7	7	2	4	0	0	1	2	0	0.615	0.986	1.000
20	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(5), CCL2(1), CSF1(4), IL6(4), LDLR(10), LPL(4)	3116487	28	28	28	6	14	0	4	2	8	0	0.252	0.987	1.000
21	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	5	FABP6(1), LDLR(10), NR0B2(2), NR1H3(3), NR1H4(4)	2620669	20	18	20	4	8	1	5	1	5	0	0.198	0.989	1.000
22	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	6	CCNE1(3), CDC34(1), CDK2(1), CUL1(19), E2F1(3), TFDP1(2)	2808284	29	29	24	6	20	0	6	1	2	0	0.181	0.993	1.000
23	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(1), CCR3(3), HLA-DRA(4), HLA-DRB1(1), IL5(1)	1774605	10	10	10	4	3	0	4	2	1	0	0.723	0.995	1.000
24	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(3), UGDH(5), UXS1(3)	2231739	12	11	12	3	3	2	2	3	2	0	0.577	0.996	1.000
25	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(7), CYP11A1(1), CYP11B2(13), CYP17A1(3), HSD11B2(3), HSD3B1(5), HSD3B2(5)	4025170	37	32	37	8	19	1	13	4	0	0	0.0452	0.997	1.000
26	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(3), CD4(3), CD80(2), HLA-DRA(4), HLA-DRB1(1), IL10(1), IL2(1)	2318348	15	15	15	4	8	1	4	2	0	0	0.333	0.997	1.000
27	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(3), GSTZ1(2), HGD(4)	1306225	9	9	9	4	5	0	0	2	2	0	0.814	0.998	1.000
28	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(4), CCNE1(3), CDC34(1), CDK2(1), CUL1(19), E2F1(3), SKP2(5), TFDP1(2)	3949781	38	38	33	8	25	0	8	2	3	0	0.149	0.998	1.000
29	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(5), CYP11A1(1), CYP11B1(4), CYP11B2(13), CYP17A1(3), CYP21A2(2), HSD11B2(3), HSD3B1(5), HSD3B2(5)	5333840	46	39	46	9	23	3	15	5	0	0	0.0280	0.999	1.000
30	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(5), CYP11A1(1), CYP11B1(4), CYP11B2(13), CYP17A1(3), CYP21A2(2), HSD11B2(3), HSD3B1(5), HSD3B2(5)	5333840	46	39	46	9	23	3	15	5	0	0	0.0280	0.999	1.000
31	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), CDC42(4), RAC1(4), WASF1(5), WASL(2)	4739468	39	35	39	6	19	3	5	4	8	0	0.129	0.999	1.000
32	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(2)	1229445	5	5	5	3	1	1	2	1	0	0	0.889	0.999	1.000
33	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(1), IFNGR2(6), JAK1(9), JAK2(8), STAT1(13)	4799687	39	35	38	7	17	1	7	3	11	0	0.182	1.000	1.000
34	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(2), SNAP25(4), STX1A(1), VAMP2(1)	1901498	10	10	10	4	5	1	2	1	1	0	0.634	1.000	1.000
35	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(17), EGFR(7), ERBB3(48), NRG1(14), UBE2D1(2)	6010906	88	75	77	16	40	7	23	10	8	0	0.0532	1.000	1.000
36	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(6), CPS1(13), GLS(3), GLUD1(6), GOT1(2)	4538906	32	26	30	6	17	1	5	4	5	0	0.166	1.000	1.000
37	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(5), ACAT2(1), HMGCL(1), OXCT1(4)	1983004	11	10	11	7	7	1	0	1	2	0	0.975	1.000	1.000
38	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(6), LPO(8), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), TPO(16), TYR(12)	5592311	63	50	62	13	30	3	19	4	7	0	0.0349	1.000	1.000
39	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(3), GLS2(4), GLUD1(6), GLUD2(10)	2657960	23	21	22	6	10	1	7	1	4	0	0.518	1.000	1.000
40	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(3), FUT2(6), FUT3(3), FUT5(5), FUT6(2), ST3GAL3(3)	2957408	22	21	21	6	13	0	7	0	2	0	0.230	1.000	1.000
41	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	5	ESR1(5), MAPK3(8), PELP1(5), SRC(5)	2853407	23	23	22	7	12	1	7	2	1	0	0.425	1.000	1.000
42	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDPS(6), HMGCR(7), IDI1(2), LSS(7), MVD(4), NQO2(3), PMVK(1), SQLE(4), VKORC1(1)	6362305	38	33	38	6	21	2	6	5	4	0	0.0390	1.000	1.000
43	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(4), DHCR7(3), FDPS(6), HMGCR(7), HMGCS1(9), IDI1(2), LSS(7), MVD(4), NSDHL(3), PMVK(1), SQLE(4)	7606406	50	44	50	8	28	2	8	8	4	0	0.0289	1.000	1.000
44	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	6	CDC25A(5), CDC25B(2), CDK7(6), CHEK1(3), NEK1(5), WEE1(10)	3772729	31	26	31	7	18	5	1	0	7	0	0.709	1.000	1.000
45	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB1A(1), RAB27A(1), RAB3A(2), RAB5A(2), RAB6A(5), RAB9A(1)	2475444	17	15	17	6	7	2	2	3	3	0	0.791	1.000	1.000
46	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(5), BLVRB(1), HMOX1(3), IL10(1), IL10RA(9), IL10RB(8), IL1A(1), IL6(4), JAK1(9), STAT1(13), STAT3(6), STAT5A(1), TNF(4)	7122262	65	55	64	13	31	0	11	3	20	0	0.0220	1.000	1.000
47	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), FARSB(6), GOT1(2), PAH(11), TAT(5), YARS(5), YARS2(8)	5069669	40	37	40	9	17	2	5	7	9	0	0.201	1.000	1.000
48	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(3), B3GALT5(3), B3GNT5(8), FUT1(3), FUT2(6), FUT3(3), ST3GAL3(3), ST3GAL4(1)	4212211	32	23	32	9	22	0	7	1	2	0	0.265	1.000	1.000
49	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(1), EHHADH(6), HADHA(4), SDS(2)	2817763	15	15	15	8	11	1	0	0	3	0	0.918	1.000	1.000
50	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(6), GGPS1(1), IDI1(2), IDI2(4), SQLE(4)	2479141	17	17	17	5	7	0	6	3	1	0	0.587	1.000	1.000
51	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACADS(6), ACAT1(5), ECHS1(1), HADHA(4)	3151489	19	19	19	8	11	0	3	2	3	0	0.874	1.000	1.000
52	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(6), GBA(4), LPO(8), MPO(4), PRDX6(5), TPO(16)	4842840	43	38	43	10	19	2	14	4	4	0	0.125	1.000	1.000
53	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(65), ATR(32), CDC25C(2), CHEK1(3), CHEK2(11), YWHAH(2)	8894561	115	90	111	15	54	7	13	18	21	2	0.0247	1.000	1.000
54	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(5), ALDOB(3), ALDOC(2), TPI1(1)	2282528	11	11	11	9	5	1	3	1	1	0	0.985	1.000	1.000
55	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(4), FOSL1(3), FOSL2(5), IFNAR1(2), IFNAR2(5), IFNB1(1), MAPK8(5), NFKB1(3), RELA(6), TNFRSF11A(1), TNFSF11(1), TRAF6(1)	6421901	37	33	36	9	18	1	5	1	11	1	0.582	1.000	1.000
56	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(7), DNAJC3(6), EIF2S1(5), EIF2S2(1), NFKB1(3), NFKBIA(6), RELA(6)	5177373	34	28	34	6	23	2	2	1	6	0	0.209	1.000	1.000
57	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(1), DAG1(3), GNAQ(3), ITPKA(4), ITPKB(5)	3476319	20	20	20	6	10	1	5	4	0	0	0.479	1.000	1.000
58	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(14), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(2), APOBEC3C(3), APOBEC3F(1), APOBEC4(7)	4289239	33	29	33	9	23	2	6	2	0	0	0.359	1.000	1.000
59	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(4), ACAA2(2), ACAT1(5), ACAT2(1), ECHS1(1), EHHADH(6), HADHA(4), HADHB(4), SDS(2)	4887057	29	25	28	9	19	2	0	1	7	0	0.674	1.000	1.000
60	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(3), CD4(3), HLA-DRA(4), HLA-DRB1(1), IL1B(3), IL5(1), IL5RA(4), IL6(4)	3126878	23	20	23	9	11	1	5	4	2	0	0.680	1.000	1.000
61	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(12), GABRA2(6), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), PRKCE(5), SOD1(4)	4593551	59	52	59	15	14	3	20	14	8	0	0.294	1.000	1.000
62	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(11), GABARAP(3), GABRA1(12), GABRA2(6), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GPHN(5), NSF(6), SRC(5), UBQLN1(5)	6922805	85	68	84	19	28	4	24	18	11	0	0.143	1.000	1.000
63	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(2), GLS(3), GLUD1(6), OAT(1), PRODH(3)	3204178	19	18	18	7	12	2	3	0	2	0	0.775	1.000	1.000
64	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), ATP6V0C(2), CAT(9), EPX(6), LPO(8), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), SHMT1(3), SHMT2(2), TPO(16)	6839783	68	55	67	16	35	2	17	6	8	0	0.0561	1.000	1.000
65	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(6), LARS(11), LARS2(3), PDHA1(5), PDHA2(6), PDHB(1)	5836285	36	31	36	7	19	1	6	3	7	0	0.312	1.000	1.000
66	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP1(2), RANBP2(28), RANGAP1(4)	4925357	35	32	35	8	19	4	5	2	5	0	0.710	1.000	1.000
67	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL15(1), IL16(13), IL1A(1), IL2(1), IL5(1), IL6(4), LTA(1), TNF(4)	5783775	35	31	35	9	22	0	7	2	4	0	0.222	1.000	1.000
68	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(5), GOT1(2), LDHB(2), LDHC(4), MPST(1)	3992401	18	18	18	8	10	2	3	1	2	0	0.859	1.000	1.000
69	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(9), LDLR(10), MBTPS1(13), MBTPS2(7), SCAP(9), SREBF1(6), SREBF2(8)	6841875	62	55	61	16	29	1	14	4	14	0	0.136	1.000	1.000
70	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), P2RY1(3), P2RY2(1), P2RY6(2)	3479393	16	14	16	9	4	1	4	6	1	0	0.759	1.000	1.000
71	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(11), CD44(2), CSF1(4), FCGR3A(6), IL1B(3), IL6R(4), SPN(6), TGFB1(2), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TNFRSF8(8), TNFSF8(4)	7576664	65	47	62	14	31	0	21	4	9	0	0.0519	1.000	1.000
72	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(3), CDK2(1), CDKN1B(6), CUL1(19), E2F1(3), NEDD8(2), RBX1(1), SKP2(5), TFDP1(2), UBE2M(3)	3979020	45	41	40	12	28	0	8	3	6	0	0.310	1.000	1.000
73	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(3)	8771309	76	63	75	17	37	6	12	10	11	0	0.0689	1.000	1.000
74	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(3)	8771309	76	63	75	17	37	6	12	10	11	0	0.0689	1.000	1.000
75	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(3)	8771309	76	63	75	17	37	6	12	10	11	0	0.0689	1.000	1.000
76	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(9), EPX(6), LPO(8), MPO(4), MTHFR(4), PRDX6(5), SHMT1(3), SHMT2(2), TPO(16)	6743191	58	49	58	15	27	3	17	5	6	0	0.140	1.000	1.000
77	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), DDC(8), EPX(6), GOT1(2), HPD(4), LPO(8), MAOA(4), MAOB(2), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), TAT(5), TPO(16)	12703476	104	78	103	23	50	3	26	9	16	0	0.00744	1.000	1.000
78	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	GRB2(1), PTK2B(6), SHC1(8), SOS1(23), SRC(5)	4868716	43	36	42	10	25	1	8	6	3	0	0.319	1.000	1.000
79	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(3), PSMA5(5), PSMA6(6), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC3(5), RPN1(3), RPN2(5), UBE2A(2), UBE3A(10)	7496769	58	52	57	12	36	1	9	7	5	0	0.152	1.000	1.000
80	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7)	7687900	48	43	48	12	21	2	11	4	10	0	0.197	1.000	1.000
81	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	4	LPL(4), NCOA1(24), NCOA2(12), PPARG(13)	4600264	53	44	50	11	29	1	10	4	9	0	0.370	1.000	1.000
82	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(12), EIF2AK4(11), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF5(9), GSK3B(4), PPP1CA(8)	6762412	67	51	67	13	35	1	15	6	10	0	0.189	1.000	1.000
83	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), IFNGR1(1), JAK1(9), JAK2(8), PLA2G2A(2), PTPRU(7), REG1A(8), STAT1(13)	6688362	51	46	50	12	23	0	15	4	9	0	0.228	1.000	1.000
84	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), BCAT2(3), IARS(6), IARS2(10), ILVBL(3), LARS(11), LARS2(3), PDHA1(5), PDHA2(6), PDHB(1), VARS(5), VARS2(12)	10782385	69	58	69	12	36	3	18	3	9	0	0.0465	1.000	1.000
85	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), CDC42(4), PAK1(4), PDGFRA(16), PIK3R1(6), RAC1(4), WASL(2)	6548674	56	50	56	12	24	2	10	5	15	0	0.312	1.000	1.000
86	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	9	DAXX(9), PAX3(8), PML(7), RARA(4), SIRT1(9), SP100(13), TNF(4), TNFRSF1A(5), TNFRSF1B(6)	6506125	65	59	62	15	36	0	19	6	4	0	0.194	1.000	1.000
87	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), FDXR(5), SHMT1(3)	9323680	81	67	80	20	42	6	12	10	11	0	0.100	1.000	1.000
88	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(4), IL6R(4), JAK1(9), JAK2(8), JAK3(12), PIAS3(5), PTPRU(7), REG1A(8), SRC(5), STAT3(6)	8831183	69	58	69	18	32	2	21	4	10	0	0.172	1.000	1.000
89	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(6), ADRB2(3), CFTR(18), GNAS(12), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5)	7603732	59	47	59	14	26	3	14	10	6	0	0.210	1.000	1.000
90	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	186	ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), AKT1(3), AKT2(4), AKT3(6), ARHGAP5(12), BAD(2), BCAR1(6), BIRC2(3), BIRC3(3), BRAF(9), CAPN2(2), CAV2(1), CAV3(1), CCND1(4), CCND2(1), CCND3(5), CDC42(4), CHAD(3), COL11A1(29), COL11A2(13), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(6), COL6A3(27), COL6A6(28), COMP(8), CRK(4), CRKL(1), DIAPH1(5), DOCK1(11), EGF(17), EGFR(7), ELK1(1), FARP2(7), FIGF(2), FLNA(14), FLNB(23), FLNC(18), FLT1(8), FN1(20), FYN(7), GRB2(1), GSK3B(4), HGF(12), IBSP(4), IGF1(2), IGF1R(11), ILK(3), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAV(13), ITGB1(3), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), JUN(4), KDR(19), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(22), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), MAP2K1(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MET(19), MYL2(4), MYL5(2), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PARVB(6), PARVG(3), PDGFB(2), PDGFC(5), PDGFD(8), PDGFRA(16), PDGFRB(7), PDPK1(2), PGF(2), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP5K1C(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PRKCA(3), PRKCG(6), PTK2(12), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF1(6), RELN(36), ROCK1(8), ROCK2(15), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SPP1(2), SRC(5), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TLN1(17), TLN2(13), TNC(19), TNN(20), TNR(12), TNXB(38), VASP(1), VAV1(8), VAV2(8), VAV3(7), VCL(4), VEGFA(4), VEGFB(3), VEGFC(6), VTN(3), VWF(21), ZYX(4)	210014394	1635	348	1610	545	770	71	395	176	223	0	0.977	1.000	1.000
91	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY7(4), ADCY8(18), ADCY9(8), ADORA2A(1), ADORA2B(1), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRB1(3), ADRB2(3), AGTR1(3), ATP2A1(9), ATP2A2(10), ATP2A3(5), ATP2B1(11), ATP2B2(13), ATP2B3(3), ATP2B4(15), AVPR1A(4), AVPR1B(3), BDKRB1(4), BDKRB2(2), BST1(3), CACNA1A(25), CACNA1B(17), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1F(11), CACNA1G(16), CACNA1H(12), CACNA1I(8), CACNA1S(12), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CCKAR(3), CCKBR(8), CD38(1), CHRM1(2), CHRM2(5), CHRM3(8), CHRM5(3), CHRNA7(2), CYSLTR2(2), DRD1(2), EDNRA(4), EDNRB(8), EGFR(7), ERBB3(48), ERBB4(11), F2R(2), GNA11(3), GNA14(3), GNA15(5), GNAL(4), GNAQ(3), GNAS(12), GRIN1(7), GRIN2A(14), GRIN2C(10), GRIN2D(9), GRM1(22), GRM5(18), GRPR(1), HRH1(9), HRH2(1), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), LHCGR(7), LTB4R2(3), MYLK(15), MYLK2(7), NOS1(15), NOS3(11), NTSR1(2), OXTR(1), P2RX1(3), P2RX2(8), P2RX3(4), P2RX5(2), P2RX7(5), PDE1A(8), PDE1B(4), PDE1C(15), PDGFRA(16), PDGFRB(7), PHKA1(14), PHKA2(8), PHKB(10), PHKG1(3), PHKG2(3), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLCD1(5), PLCD3(6), PLCD4(5), PLCE1(10), PLCG1(12), PLCG2(6), PLCZ1(5), PLN(2), PPID(2), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKX(1), PTAFR(1), PTGER3(2), PTGFR(7), PTK2B(6), RYR1(54), RYR2(83), RYR3(53), SLC25A4(2), SLC25A6(1), SLC8A1(8), SLC8A2(11), SLC8A3(5), SPHK1(1), SPHK2(10), TACR1(3), TACR2(1), TACR3(5), TNNC1(2), TNNC2(1), TRHR(9), TRPC1(9), VDAC1(3), VDAC2(3)	153728172	1270	331	1244	568	582	62	336	130	158	2	1.000	1.000	1.000
92	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	196	ABI2(7), ACTN1(7), ACTN2(10), ACTN4(13), APC(29), APC2(6), ARAF(2), ARHGEF1(8), ARHGEF12(14), ARHGEF4(3), ARHGEF6(7), ARHGEF7(9), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), ARPC5(5), BAIAP2(5), BCAR1(6), BDKRB1(4), BDKRB2(2), BRAF(9), CD14(3), CDC42(4), CFL1(1), CFL2(4), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CRK(4), CRKL(1), CSK(7), CYFIP1(7), CYFIP2(9), DIAPH1(5), DIAPH3(7), DOCK1(11), EGF(17), EGFR(7), EZR(12), F2(3), F2R(2), FGD1(6), FGD3(4), FGF1(2), FGF10(4), FGF11(1), FGF12(5), FGF13(5), FGF14(6), FGF16(2), FGF17(1), FGF19(2), FGF23(3), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(1), FGF8(3), FGF9(4), FGFR1(6), FGFR2(10), FGFR4(6), FN1(20), GIT1(6), GNA12(3), GNA13(12), GNG12(2), GSN(2), IQGAP1(11), IQGAP2(10), IQGAP3(12), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAD(4), ITGAE(11), ITGAL(17), ITGAM(13), ITGAV(13), ITGAX(3), ITGB1(3), ITGB2(7), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), LIMK1(6), LIMK2(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MOS(2), MRAS(2), MSN(1), MYH10(24), MYH14(7), MYH9(35), MYL2(4), MYL5(2), MYLK(15), MYLK2(7), NCKAP1(12), NCKAP1L(10), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PDGFB(2), PDGFRA(16), PDGFRB(7), PFN1(4), PFN2(1), PFN3(1), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PPP1R12B(10), PTK2(12), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RDX(4), ROCK1(8), ROCK2(15), RRAS(2), RRAS2(1), SCIN(1), SLC9A1(7), SOS1(23), SOS2(8), SSH1(7), SSH2(18), SSH3(17), TIAM1(17), TIAM2(18), VAV1(8), VAV2(8), VAV3(7), VCL(4), WAS(4), WASF1(5), WASF2(7), WASL(2)	155508491	1235	325	1214	415	638	50	241	137	169	0	0.857	1.000	1.000
93	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(2), ACVR1C(3), AKT1(3), AKT2(4), AKT3(6), ARRB1(4), ARRB2(4), ATF2(1), ATF4(3), BDNF(3), BRAF(9), CACNA1A(25), CACNA1B(17), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1F(11), CACNA1G(16), CACNA1H(12), CACNA1I(8), CACNA1S(12), CACNA2D1(19), CACNA2D2(6), CACNA2D3(8), CACNA2D4(8), CACNB1(5), CACNB2(8), CACNB3(5), CACNB4(3), CACNG1(1), CACNG2(3), CACNG3(4), CACNG4(8), CACNG5(7), CACNG6(3), CACNG7(8), CACNG8(3), CASP3(3), CD14(3), CDC25B(2), CDC42(4), CHUK(7), CRK(4), CRKL(1), DAXX(9), DDIT3(1), DUSP1(3), DUSP10(4), DUSP14(4), DUSP16(6), DUSP2(2), DUSP4(2), DUSP5(1), DUSP6(7), DUSP7(4), DUSP8(6), DUSP9(3), ECSIT(4), EGF(17), EGFR(7), ELK1(1), ELK4(6), FAS(1), FASLG(1), FGF1(2), FGF10(4), FGF11(1), FGF12(5), FGF13(5), FGF14(6), FGF16(2), FGF17(1), FGF19(2), FGF23(3), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(1), FGF8(3), FGF9(4), FGFR1(6), FGFR2(10), FGFR4(6), FLNA(14), FLNB(23), FLNC(18), FOS(4), GADD45A(1), GADD45G(1), GNA12(3), GNG12(2), GRB2(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), JUN(4), JUND(2), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K5(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K6(9), MAP3K7(8), MAP3K8(5), MAP4K1(8), MAP4K2(5), MAP4K3(12), MAP4K4(7), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK7(3), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MAPKAPK2(1), MAPKAPK3(3), MAPKAPK5(3), MAPT(10), MEF2C(5), MKNK1(6), MKNK2(3), MOS(2), MRAS(2), MYC(2), NF1(38), NFATC2(13), NFATC4(5), NFKB1(3), NFKB2(3), NLK(6), NR4A1(2), NTF3(1), NTRK1(6), NTRK2(7), PAK1(4), PAK2(9), PDGFB(2), PDGFRA(16), PDGFRB(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PPM1A(6), PPM1B(7), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PPP5C(7), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKX(1), PTPN5(2), PTPN7(1), PTPRR(7), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF2(16), RASA1(8), RASA2(6), RASGRF1(12), RASGRF2(9), RASGRP1(6), RASGRP2(4), RASGRP3(5), RASGRP4(1), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA4(3), RPS6KA5(9), RPS6KA6(11), RRAS(2), RRAS2(1), SOS1(23), SOS2(8), SRF(4), STK3(7), STK4(6), TAOK1(11), TAOK2(13), TAOK3(15), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8), TNF(4), TNFRSF1A(5), TRAF2(5), TRAF6(1), ZAK(10)	162656857	1293	323	1279	500	617	52	282	142	195	5	1.000	1.000	1.000
94	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(20), ACTG1(11), CHAD(3), COL11A1(29), COL11A2(13), COL17A1(8), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(6), COL6A3(27), COL6A6(28), COMP(8), DES(2), DSC1(9), DSC2(4), DSC3(10), DSG1(12), DSG2(11), DSG3(7), DSG4(9), FN1(20), GJA1(3), GJA10(4), GJA3(3), GJA4(2), GJA5(5), GJA8(4), GJA9(6), GJB2(2), GJB3(3), GJB5(4), GJB6(2), GJB7(1), GJC1(1), GJC3(1), GJD2(4), GJD4(4), IBSP(4), INA(2), ITGA6(9), ITGB4(15), KRT1(2), KRT10(6), KRT12(4), KRT13(4), KRT14(3), KRT15(5), KRT16(5), KRT17(4), KRT18(5), KRT19(8), KRT2(4), KRT20(7), KRT23(2), KRT24(7), KRT25(2), KRT27(4), KRT28(4), KRT3(4), KRT31(2), KRT32(3), KRT33A(3), KRT33B(9), KRT34(3), KRT35(3), KRT36(5), KRT37(1), KRT38(6), KRT39(5), KRT4(4), KRT40(4), KRT5(7), KRT6A(6), KRT6B(3), KRT6C(6), KRT7(2), KRT71(6), KRT72(3), KRT73(4), KRT74(2), KRT75(6), KRT76(5), KRT77(4), KRT78(5), KRT79(6), KRT8(5), KRT82(3), KRT83(5), KRT84(10), KRT85(3), KRT9(4), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(22), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), LMNA(5), LMNB1(4), LMNB2(7), NES(20), PRPH(4), RELN(36), SPP1(2), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNC(19), TNN(20), TNR(12), TNXB(38), VIM(7), VTN(3), VWF(21)	144100947	1146	319	1124	420	551	51	300	101	142	1	1.000	1.000	1.000
95	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(7), ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), ADRA1A(5), ADRA1B(1), ADRA2A(3), ADRA2B(1), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(4), AVPR1B(3), AVPR2(3), BDKRB1(4), BDKRB2(2), BRS3(4), C3AR1(4), C5AR1(3), CALCR(9), CALCRL(8), CCKAR(3), CCKBR(8), CGA(2), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CNR1(4), CNR2(6), CRHR1(2), CRHR2(3), CTSG(4), CYSLTR2(2), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), EDNRA(4), EDNRB(8), F2(3), F2R(2), F2RL1(5), F2RL2(2), F2RL3(2), FPR1(3), FSHB(1), FSHR(5), GABBR1(6), GABBR2(6), GABRA1(12), GABRA2(6), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GABRB1(7), GABRB2(7), GABRB3(9), GABRD(3), GABRE(6), GABRG1(9), GABRG2(5), GABRG3(4), GABRP(3), GABRQ(6), GABRR1(6), GABRR2(2), GALR1(3), GALR2(4), GALR3(3), GH1(3), GH2(3), GHR(6), GHRHR(3), GHSR(6), GIPR(3), GLP1R(3), GLP2R(2), GLRA1(6), GLRA2(4), GLRA3(5), GLRB(3), GNRHR(2), GPR156(7), GPR35(2), GPR63(3), GPR83(3), GRIA1(16), GRIA2(7), GRIA3(6), GRIA4(21), GRID1(12), GRID2(12), GRIK1(12), GRIK2(15), GRIK3(15), GRIK4(7), GRIK5(14), GRIN1(7), GRIN2A(14), GRIN2B(10), GRIN2C(10), GRIN2D(9), GRIN3A(5), GRIN3B(2), GRM1(22), GRM2(10), GRM3(8), GRM4(9), GRM5(18), GRM6(9), GRM7(12), GRM8(8), GRPR(1), GZMA(4), HCRTR1(1), HCRTR2(10), HRH1(9), HRH2(1), HRH3(4), HRH4(3), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), LEP(1), LEPR(8), LHB(2), LHCGR(7), LTB4R2(3), MAS1(2), MC1R(2), MC3R(4), MC4R(3), MC5R(3), MCHR1(3), MCHR2(3), MLNR(3), MTNR1A(4), MTNR1B(1), NMBR(6), NMUR2(1), NPBWR2(4), NPFFR1(2), NPFFR2(6), NPY1R(7), NPY2R(4), NPY5R(5), NR3C1(6), NTSR1(2), NTSR2(2), OPRD1(5), OPRK1(4), OPRL1(2), OXTR(1), P2RX1(3), P2RX2(8), P2RX3(4), P2RX5(2), P2RX7(5), P2RY1(3), P2RY10(2), P2RY11(1), P2RY13(3), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(2), P2RY8(1), PARD3(22), PRL(3), PRLHR(4), PRLR(4), PRSS1(2), PTAFR(1), PTGDR(3), PTGER2(7), PTGER3(2), PTGER4(5), PTGFR(7), PTGIR(2), PTH2R(8), RXFP1(8), RXFP2(4), SCTR(4), SSTR1(3), SSTR3(4), SSTR4(6), SSTR5(1), TAAR1(3), TAAR5(2), TAAR6(3), TAAR8(4), TACR1(3), TACR2(1), TACR3(5), THRA(2), THRB(1), TRHR(9), TRPV1(3), TSHR(8), UTS2R(1), VIPR1(1), VIPR2(4)	127980841	1062	318	1052	506	430	49	311	142	129	1	0.999	1.000	1.000
96	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(12), CD36(2), CD44(2), CD47(2), CHAD(3), COL11A1(29), COL11A2(13), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(6), COL6A3(27), COL6A6(28), DAG1(3), FN1(20), FNDC1(17), FNDC3A(12), GP5(1), GP6(3), GP9(3), HMMR(2), HSPG2(33), IBSP(4), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAV(13), ITGB1(3), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(22), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), RELN(36), SDC1(4), SDC2(3), SDC3(2), SDC4(1), SPP1(2), SV2A(6), SV2B(6), SV2C(6), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNC(19), TNN(20), TNR(12), TNXB(38), VTN(3), VWF(21)	129159742	1005	313	992	354	469	46	250	98	142	0	0.998	1.000	1.000
97	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	123	ABL1(9), ABLIM1(7), ABLIM2(3), ABLIM3(2), ARHGEF12(14), CDC42(4), CDK5(3), CFL1(1), CFL2(4), CXCR4(4), DCC(26), DPYSL2(4), DPYSL5(1), EFNA1(1), EFNA2(1), EFNA3(1), EFNA4(1), EFNA5(2), EFNB1(3), EFNB2(6), EFNB3(4), EPHA1(4), EPHA2(20), EPHA3(20), EPHA4(2), EPHA5(23), EPHA6(14), EPHA7(12), EPHA8(10), EPHB1(14), EPHB2(10), EPHB3(12), EPHB4(7), EPHB6(11), FES(3), FYN(7), GNAI1(4), GNAI2(5), GNAI3(6), GSK3B(4), ITGB1(3), L1CAM(8), LIMK1(6), LIMK2(4), LRRC4C(8), MAPK3(8), MET(19), NCK1(2), NCK2(5), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NGEF(5), NRP1(8), NTN1(5), NTN4(4), NTNG1(6), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PLXNA1(8), PLXNA2(17), PLXNA3(7), PLXNB1(13), PLXNB2(22), PLXNB3(9), PLXNC1(9), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PTK2(12), RAC1(4), RAC2(1), RAC3(3), RASA1(8), RGS3(3), RND1(4), ROBO1(17), ROBO2(22), ROBO3(6), ROCK1(8), ROCK2(15), SEMA3A(11), SEMA3C(9), SEMA3D(18), SEMA3E(13), SEMA3F(6), SEMA3G(8), SEMA4A(9), SEMA4B(3), SEMA4C(5), SEMA4D(3), SEMA4F(3), SEMA4G(6), SEMA5A(7), SEMA5B(16), SEMA6A(5), SEMA6B(6), SEMA6C(8), SEMA6D(12), SEMA7A(3), SLIT1(10), SLIT2(17), SLIT3(11), SRGAP1(7), SRGAP2(10), SRGAP3(7), UNC5A(5), UNC5B(10), UNC5C(17), UNC5D(9)	112697994	929	305	922	320	407	44	249	104	123	2	0.853	1.000	1.000
98	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	125	ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), AKT1(3), AKT2(4), AKT3(6), AMOTL1(8), ASH1L(35), CASK(9), CDC42(4), CDK4(5), CGN(10), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CSNK2A1(11), CSNK2B(5), CTNNA1(6), CTNNA2(21), CTNNA3(11), CTTN(9), EPB41(9), EPB41L1(8), EPB41L2(8), EPB41L3(17), EXOC3(8), EXOC4(13), F11R(5), GNAI1(4), GNAI2(5), GNAI3(6), HCLS1(5), IGSF5(4), INADL(16), JAM2(1), JAM3(4), LLGL1(4), LLGL2(5), MAGI1(15), MAGI2(17), MAGI3(16), MLLT4(15), MPDZ(20), MPP5(5), MRAS(2), MYH1(16), MYH10(24), MYH11(22), MYH13(21), MYH14(7), MYH15(22), MYH2(22), MYH3(19), MYH4(21), MYH6(14), MYH7(19), MYH7B(16), MYH8(17), MYH9(35), MYL2(4), MYL5(2), OCLN(4), PARD3(22), PARD6A(7), PARD6B(5), PARD6G(1), PPM1J(3), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(3), PPP2R2C(4), PPP2R3A(13), PPP2R3B(4), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), RAB13(2), RAB3B(5), RRAS(2), RRAS2(1), SPTAN1(68), SRC(5), SYMPK(11), TJAP1(2), TJP1(9), TJP2(13), TJP3(4), VAPA(6), YES1(6), ZAK(10)	110403151	1017	305	1003	320	517	57	189	81	171	2	0.689	1.000	1.000
99	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRB1(3), ADRB2(3), ANXA6(6), ARRB1(4), ARRB2(4), ATP1A4(11), ATP1B1(1), ATP1B2(5), ATP1B3(1), ATP2A2(10), ATP2A3(5), ATP2B1(11), ATP2B2(13), ATP2B3(3), CACNA1A(25), CACNA1B(17), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1S(12), CACNB1(5), CACNB3(5), CALM1(2), CALM2(2), CALR(4), CAMK1(5), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CASQ1(7), CASQ2(5), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), GJA1(3), GJA4(2), GJA5(5), GJB2(2), GJB3(3), GJB5(4), GJB6(2), GNA11(3), GNAI2(5), GNAI3(6), GNAO1(2), GNAQ(3), GNAZ(3), GNB1(7), GNB3(5), GNB4(5), GNB5(2), GNG12(2), GNG2(1), GNG3(3), GNG4(5), GNG5(1), GRK4(2), GRK5(5), GRK6(4), ITPR1(21), ITPR2(33), ITPR3(9), KCNB1(8), KCNJ3(4), KCNJ5(2), MIB1(9), NME7(3), PEA15(2), PKIA(2), PKIB(1), PKIG(3), PLCB3(11), PLN(2), PRKACA(2), PRKACB(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), RGS1(1), RGS10(4), RGS11(1), RGS14(5), RGS16(4), RGS17(1), RGS18(6), RGS19(3), RGS2(1), RGS20(3), RGS3(3), RGS4(2), RGS5(3), RGS6(5), RGS7(8), RGS9(6), RYR1(54), RYR2(83), RYR3(53), SFN(1), SLC8A1(8), SLC8A3(5), USP5(3), YWHAB(2), YWHAH(2), YWHAQ(3)	108011816	909	296	895	421	420	44	219	95	130	1	1.000	1.000	1.000
100	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(7), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADM(3), ARRB1(4), ARRB2(4), ATF1(2), ATF2(1), ATF4(3), ATP2A2(10), ATP2A3(5), CACNB3(5), CALCA(1), CALM1(2), CALM2(2), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CNN1(3), CNN2(3), CORIN(7), CRHR1(2), DGKZ(3), ETS2(5), FOS(4), GABPA(6), GABPB2(2), GBA2(1), GJA1(3), GNAQ(3), GNB1(7), GNB3(5), GNB4(5), GNB5(2), GNG12(2), GNG2(1), GNG3(3), GNG4(5), GNG5(1), GRK4(2), GRK5(5), GRK6(4), GSTO1(2), GUCY1A3(12), IGFBP1(4), IGFBP3(1), IGFBP4(1), IGFBP6(2), IL1B(3), IL6(4), ITPR1(21), ITPR2(33), ITPR3(9), JUN(4), MIB1(9), MYL2(4), MYLK2(7), NFKB1(3), NOS1(15), NOS3(11), OXT(1), OXTR(1), PDE4B(5), PDE4D(4), PKIA(2), PKIB(1), PKIG(3), PLCB3(11), PLCD1(5), PLCG1(12), PLCG2(6), PRKACA(2), PRKACB(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), RAMP1(2), RAMP2(1), RAMP3(2), RGS1(1), RGS10(4), RGS11(1), RGS14(5), RGS16(4), RGS17(1), RGS18(6), RGS19(3), RGS2(1), RGS20(3), RGS3(3), RGS4(2), RGS5(3), RGS6(5), RGS7(8), RGS9(6), RLN1(2), RYR1(54), RYR2(83), RYR3(53), SFN(1), SLC8A1(8), SP1(10), TNXB(38), USP5(3), YWHAB(2), YWHAH(2), YWHAQ(3)	99781943	837	293	823	350	398	40	194	81	122	2	0.998	1.000	1.000
101	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(4), CADM1(6), CADM3(4), CD2(2), CD22(4), CD226(5), CD274(5), CD276(1), CD28(3), CD34(3), CD4(3), CD40(3), CD40LG(2), CD58(1), CD6(3), CD80(2), CD86(6), CD8A(2), CD99(2), CDH1(15), CDH15(8), CDH2(12), CDH3(7), CDH4(18), CDH5(9), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CNTN1(11), CNTN2(9), CNTNAP1(12), CNTNAP2(25), CTLA4(1), ESAM(1), F11R(5), GLG1(9), HLA-A(7), HLA-B(4), HLA-C(4), HLA-DMB(4), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(6), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(5), HLA-F(5), HLA-G(3), ICAM1(7), ICAM2(1), ICAM3(5), ICOS(2), ICOSLG(3), ITGA4(19), ITGA6(9), ITGA8(20), ITGA9(9), ITGAL(17), ITGAM(13), ITGAV(13), ITGB1(3), ITGB2(7), ITGB7(3), ITGB8(11), JAM2(1), JAM3(4), L1CAM(8), MADCAM1(1), MAG(4), MPZ(5), MPZL1(3), NCAM1(9), NCAM2(16), NEGR1(2), NEO1(12), NFASC(11), NLGN1(11), NLGN2(3), NLGN3(6), NRCAM(16), NRXN1(24), NRXN2(11), NRXN3(10), OCLN(4), PDCD1(3), PDCD1LG2(3), PTPRC(19), PTPRF(14), PTPRM(17), PVR(4), PVRL1(10), PVRL2(5), PVRL3(5), SDC1(4), SDC2(3), SDC3(2), SDC4(1), SELE(7), SELP(7), SELPLG(3), SIGLEC1(12), SPN(6), VCAM1(14), VCAN(37)	85441016	774	288	761	263	353	40	171	92	117	1	0.734	1.000	1.000
102	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(7), ACVR1B(2), ACVR2A(3), ACVR2B(2), AMHR2(2), BMP2(1), BMP7(4), BMPR1A(3), BMPR1B(4), BMPR2(9), CCL1(3), CCL13(2), CCL14(2), CCL15(1), CCL16(1), CCL17(1), CCL2(1), CCL21(2), CCL22(2), CCL23(1), CCL25(2), CCL26(1), CCL27(1), CCL28(1), CCL3(2), CCL5(1), CCL7(2), CCR1(1), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(4), CCR9(1), CD27(6), CD40(3), CD40LG(2), CD70(1), CLCF1(3), CNTF(5), CNTFR(1), CRLF2(2), CSF1(4), CSF1R(11), CSF2RA(7), CSF2RB(5), CSF3(1), CSF3R(4), CX3CL1(9), CX3CR1(4), CXCL1(1), CXCL10(2), CXCL11(1), CXCL13(2), CXCL14(2), CXCL2(1), CXCL5(1), CXCL6(1), CXCL9(3), CXCR3(3), CXCR4(4), CXCR6(4), EDA(6), EDA2R(1), EDAR(3), EGF(17), EGFR(7), EPO(2), EPOR(5), FAS(1), FASLG(1), FLT1(8), FLT3(10), FLT3LG(1), FLT4(10), GDF5(2), GH1(3), GH2(3), GHR(6), HGF(12), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(5), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IFNK(4), IFNW1(2), IL10(1), IL10RA(9), IL10RB(8), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL13RA1(2), IL15(1), IL15RA(1), IL17A(2), IL17B(3), IL17RA(4), IL17RB(2), IL18R1(4), IL18RAP(9), IL19(2), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), IL1RAP(5), IL2(1), IL20(1), IL20RA(6), IL21(3), IL21R(8), IL22(1), IL22RA1(4), IL22RA2(3), IL23A(1), IL23R(4), IL24(2), IL26(1), IL2RA(1), IL2RB(2), IL2RG(5), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL6ST(9), IL7(1), IL7R(7), IL9R(3), INHBA(3), INHBB(3), INHBC(1), INHBE(6), KDR(19), KIT(9), KITLG(5), LEP(1), LEPR(8), LIF(2), LIFR(9), LTA(1), LTB(3), LTBR(3), MET(19), MPL(7), NGFR(4), OSM(5), OSMR(9), PDGFB(2), PDGFC(5), PDGFRA(16), PDGFRB(7), PF4V1(2), PLEKHO2(5), PPBP(2), PRL(3), PRLR(4), RELT(1), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFRSF11A(1), TNFRSF11B(3), TNFRSF13B(1), TNFRSF13C(3), TNFRSF14(2), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(5), TNFRSF1B(6), TNFRSF21(5), TNFRSF25(3), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(8), TNFRSF9(2), TNFSF10(5), TNFSF11(1), TNFSF13(2), TNFSF13B(5), TNFSF14(1), TNFSF18(4), TNFSF4(1), TNFSF8(4), TNFSF9(2), TPO(16), TSLP(3), VEGFA(4), VEGFB(3), VEGFC(6), XCL2(1)	102687070	789	282	785	270	366	27	177	95	122	2	0.684	1.000	1.000
103	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(4), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADK(3), ADSL(4), ADSS(4), ADSSL1(4), AK1(1), AK2(3), AK5(3), AK7(6), ALLC(3), AMPD1(10), AMPD2(6), AMPD3(4), APRT(1), ATIC(2), CANT1(1), DCK(4), DGUOK(1), ENPP1(7), ENPP3(5), ENTPD1(1), ENTPD2(2), ENTPD3(5), ENTPD5(4), ENTPD6(2), ENTPD8(5), FHIT(4), GART(7), GDA(7), GMPR(2), GMPR2(3), GMPS(5), GUCY1A2(11), GUCY1A3(12), GUCY1B3(8), GUCY2C(14), GUCY2D(6), GUCY2F(10), GUK1(3), HPRT1(1), IMPDH1(1), IMPDH2(1), ITPA(1), NME1(1), NME2(1), NME4(1), NME6(1), NME7(3), NPR1(8), NPR2(6), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), NUDT5(3), NUDT9(4), PAICS(4), PAPSS1(4), PAPSS2(2), PDE10A(8), PDE11A(19), PDE1A(8), PDE1C(15), PDE2A(2), PDE3B(9), PDE4A(12), PDE4B(5), PDE4C(8), PDE4D(4), PDE5A(11), PDE6H(1), PDE7A(3), PDE7B(2), PDE8A(4), PDE8B(4), PDE9A(7), PFAS(7), PKLR(8), PNPT1(10), POLA1(8), POLA2(11), POLD1(8), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLR1A(18), POLR1B(4), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2), PPAT(4), PRIM2(1), PRPS1(3), PRPS1L1(4), PRPS2(1), PRUNE(8), RFC5(5), RRM1(4), RRM2(3), RRM2B(2), XDH(11)	94682952	693	270	681	261	357	35	146	61	92	2	0.985	1.000	1.000
104	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(7), ACTN2(10), ACTN4(13), DES(2), DMD(41), MYBPC1(16), MYBPC2(8), MYBPC3(5), MYH3(19), MYH6(14), MYH7(19), MYH8(17), MYL2(4), MYOM1(17), NEB(53), TCAP(1), TMOD1(4), TNNC2(1), TNNI1(5), TNNI2(2), TNNI3(1), TNNT1(7), TNNT2(1), TNNT3(1), TPM1(3), TPM2(2), TPM3(1), TPM4(3), TTN(357), VIM(7)	78391260	645	270	640	197	314	27	142	92	64	6	0.900	1.000	1.000
105	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADRB1(3), CSNK1D(3), DRD1(2), DRD2(5), EGF(17), EGFR(7), GJA1(3), GJD2(4), GNA11(3), GNAI1(4), GNAI2(5), GNAI3(6), GNAQ(3), GNAS(12), GRB2(1), GRM1(22), GRM5(18), GUCY1A2(11), GUCY1A3(12), GUCY1B3(8), GUCY2C(14), GUCY2D(6), GUCY2F(10), HTR2A(2), HTR2B(5), HTR2C(1), ITPR1(21), ITPR2(33), ITPR3(9), MAP2K1(3), MAP2K2(5), MAP2K5(4), MAP3K2(6), MAPK3(8), MAPK7(3), NPR1(8), NPR2(6), PDGFB(2), PDGFC(5), PDGFD(8), PDGFRA(16), PDGFRB(7), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKG1(8), PRKG2(8), PRKX(1), RAF1(4), SOS1(23), SOS2(8), SRC(5), TJP1(9), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(3)	76100550	610	267	597	242	297	29	147	66	71	0	0.970	1.000	1.000
106	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	126	ACACA(27), ACACB(20), AKT1(3), AKT2(4), AKT3(6), ARAF(2), BAD(2), BRAF(9), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CBL(8), CBLB(13), CBLC(3), CRK(4), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(8), FASN(12), FBP1(3), FBP2(2), FLOT1(3), FLOT2(5), FOXO1(2), G6PC(2), G6PC2(2), GCK(1), GRB2(1), GSK3B(4), GYS1(12), GYS2(13), IKBKB(11), INPP5D(5), INSR(10), IRS1(9), IRS2(5), IRS4(18), LIPE(14), MAP2K1(3), MAP2K2(5), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MKNK1(6), MKNK2(3), PCK1(9), PCK2(2), PDE3A(11), PDE3B(9), PDPK1(2), PFKL(1), PFKM(5), PFKP(4), PHKA1(14), PHKA2(8), PHKB(10), PHKG1(3), PHKG2(3), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PKLR(8), PPARGC1A(18), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R3A(18), PPP1R3B(3), PPP1R3C(4), PPP1R3D(3), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAG1(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCI(8), PRKCZ(4), PRKX(1), PTPN1(5), PTPRF(14), PYGB(8), PYGL(4), PYGM(13), RAF1(4), RAPGEF1(6), RHEB(4), RHOQ(1), RPS6(5), RPS6KB1(4), RPS6KB2(1), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SLC2A4(4), SOCS3(1), SOCS4(1), SORBS1(10), SOS1(23), SOS2(8), SREBF1(6), TRIP10(6), TSC2(11)	89245832	707	266	699	267	366	25	146	75	94	1	0.989	1.000	1.000
107	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	139	APC(29), APC2(6), AXIN1(4), AXIN2(19), BTRC(4), CACYBP(1), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CCND1(4), CCND2(1), CCND3(5), CER1(4), CHD8(18), CSNK1A1(6), CSNK1A1L(4), CSNK1E(3), CSNK2A1(11), CSNK2B(5), CTBP1(4), CTBP2(7), CTNNBIP1(1), CUL1(19), CXXC4(1), DAAM1(10), DAAM2(9), DKK1(2), DKK2(5), DKK4(2), DVL1(5), DVL2(9), DVL3(4), FBXW11(1), FOSL1(3), FZD1(4), FZD10(9), FZD2(3), FZD3(6), FZD4(2), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GSK3B(4), JUN(4), LEF1(4), LRP5(8), LRP6(15), MAP3K7(8), MAPK10(9), MAPK8(5), MAPK9(5), MMP7(1), MYC(2), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NKD1(3), NKD2(1), NLK(6), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PORCN(2), PPARD(6), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(3), PPP2R2C(4), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRICKLE1(7), PRICKLE2(7), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKX(1), PSEN1(8), RAC1(4), RAC2(1), RAC3(3), RBX1(1), ROCK1(8), ROCK2(15), RUVBL1(6), SENP2(1), SFRP1(2), SFRP2(4), SFRP4(5), SIAH1(2), SKP1(6), SMAD2(4), SMAD3(6), SMAD4(8), SOX17(3), TBL1X(5), TBL1XR1(8), TBL1Y(3), TCF7(1), TCF7L2(1), VANGL1(5), VANGL2(3), WIF1(6), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(3), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2)	86273260	688	264	675	263	349	35	138	68	98	0	0.998	1.000	1.000
108	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(2), BRAF(9), CACNA1A(25), CRHR1(2), GNA11(3), GNA12(3), GNA13(12), GNAI1(4), GNAI2(5), GNAI3(6), GNAO1(2), GNAQ(3), GNAS(12), GNAZ(3), GRIA1(16), GRIA2(7), GRIA3(6), GRID2(12), GRM1(22), GRM5(18), GUCY1A2(11), GUCY1A3(12), GUCY1B3(8), GUCY2C(14), GUCY2D(6), GUCY2F(10), IGF1(2), IGF1R(11), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), MAP2K1(3), MAP2K2(5), MAPK3(8), NOS1(15), NOS3(11), NPR1(8), NPR2(6), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(3), PPP2R2C(4), PRKCA(3), PRKCG(6), PRKG1(8), PRKG2(8), RAF1(4), RYR1(54)	63062654	543	254	531	209	269	21	130	61	61	1	0.945	1.000	1.000
109	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	147	AKT1(3), AKT2(4), AKT3(6), BCL2L1(4), CBL(8), CBLB(13), CBLC(3), CCND1(4), CCND2(1), CCND3(5), CISH(1), CLCF1(3), CNTF(5), CNTFR(1), CRLF2(2), CSF2RA(7), CSF2RB(5), CSF3(1), CSF3R(4), EPO(2), EPOR(5), GH1(3), GH2(3), GHR(6), GRB2(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(5), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IFNK(4), IFNW1(2), IL10(1), IL10RA(9), IL10RB(8), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL13RA1(2), IL15(1), IL15RA(1), IL19(2), IL2(1), IL20(1), IL20RA(6), IL21(3), IL21R(8), IL22(1), IL22RA1(4), IL22RA2(3), IL23A(1), IL23R(4), IL24(2), IL26(1), IL2RA(1), IL2RB(2), IL2RG(5), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL6ST(9), IL7(1), IL7R(7), IL9R(3), IRF9(2), JAK1(9), JAK2(8), JAK3(12), LEP(1), LEPR(8), LIF(2), LIFR(9), MPL(7), MYC(2), OSM(5), OSMR(9), PIAS1(3), PIAS2(1), PIAS3(5), PIAS4(4), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIM1(1), PRL(3), PRLR(4), PTPN11(4), PTPN6(2), SOCS3(1), SOCS4(1), SOCS5(3), SOCS7(5), SOS1(23), SOS2(8), SPRED1(4), SPRED2(6), SPRY1(3), SPRY2(5), SPRY3(3), SPRY4(4), STAM(4), STAM2(6), STAT1(13), STAT2(4), STAT3(6), STAT4(9), STAT5A(1), STAT5B(5), STAT6(9), TPO(16), TSLP(3), TYK2(9)	77501943	563	250	556	179	274	19	113	62	93	2	0.628	1.000	1.000
110	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	79	ABL1(9), ABL2(7), AKT1(3), AKT2(4), AKT3(6), ARAF(2), AREG(2), BAD(2), BRAF(9), BTC(1), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CBL(8), CBLB(13), CBLC(3), CDKN1B(6), CRK(4), CRKL(1), EGF(17), EGFR(7), EIF4EBP1(1), ELK1(1), ERBB3(48), ERBB4(11), EREG(1), GAB1(6), GRB2(1), GSK3B(4), HBEGF(1), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MYC(2), NCK1(2), NCK2(5), NRG1(14), NRG2(2), NRG3(8), NRG4(1), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PRKCA(3), PRKCG(6), PTK2(12), RAF1(4), RPS6KB1(4), RPS6KB2(1), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SRC(5), STAT5A(1), STAT5B(5)	56006031	463	249	447	159	229	24	102	46	61	1	0.922	1.000	1.000
111	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(6), BCAR1(6), CAPN1(5), CAPN10(2), CAPN11(2), CAPN2(2), CAPN3(7), CAPN5(4), CAPN6(3), CAPN7(4), CAPN9(6), CAV2(1), CAV3(1), CDC42(4), CRK(4), CSK(7), DOCK1(11), FYN(7), GIT2(5), GRB2(1), ILK(3), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAD(4), ITGAE(11), ITGAL(17), ITGAM(13), ITGAV(13), ITGAX(3), ITGB1(3), ITGB2(7), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAPK10(9), MAPK12(2), MAPK4(5), MAPK6(4), MAPK7(3), MYLK2(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PDPK1(2), PIK3R2(4), PTK2(12), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAP1B(2), RAPGEF1(6), RHO(3), ROCK1(8), ROCK2(15), SDCCAG8(9), SEPP1(3), SHC1(8), SHC3(1), SORBS1(10), SOS1(23), SRC(5), TLN1(17), TNS1(20), VASP(1), VAV2(8), VAV3(7), VCL(4), ZYX(4)	77266507	592	246	588	205	288	26	126	77	75	0	0.882	1.000	1.000
112	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	103	ABL1(9), ANAPC1(17), ANAPC2(12), ANAPC4(8), ANAPC5(12), ANAPC7(6), ATM(65), ATR(32), BUB1(18), BUB1B(11), BUB3(3), CCNA1(4), CCNA2(3), CCNB1(5), CCNB3(9), CCND1(4), CCND2(1), CCND3(5), CCNE1(3), CCNE2(7), CCNH(4), CDC14A(5), CDC14B(10), CDC16(4), CDC20(4), CDC23(1), CDC25A(5), CDC25B(2), CDC25C(2), CDC27(12), CDC6(9), CDC7(4), CDK2(1), CDK4(5), CDK6(5), CDK7(6), CDKN1B(6), CDKN2B(2), CDKN2C(2), CDKN2D(1), CHEK1(3), CHEK2(11), CUL1(19), DBF4(11), E2F1(3), E2F2(4), E2F3(5), ESPL1(17), FZR1(5), GADD45A(1), GADD45G(1), GSK3B(4), HDAC1(4), HDAC2(3), MAD1L1(3), MAD2L1(3), MAD2L2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), PCNA(4), PKMYT1(2), PLK1(5), PRKDC(35), PTTG1(2), RBL1(9), RBL2(9), RBX1(1), SFN(1), SKP1(6), SKP2(5), SMAD2(4), SMAD3(6), SMAD4(8), SMC1A(16), SMC1B(8), TFDP1(2), TGFB1(2), TGFB3(1), WEE1(10), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6)	71150969	620	245	603	153	327	26	88	68	106	5	0.131	1.000	1.000
113	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(7), ACTN2(10), ACTN4(13), ARHGAP5(12), BCAR1(6), CD99(2), CDC42(4), CDH5(9), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CTNNA1(6), CTNNA2(21), CTNNA3(11), CTNND1(10), CXCR4(4), CYBA(2), CYBB(1), ESAM(1), EZR(12), F11R(5), GNAI1(4), GNAI2(5), GNAI3(6), ICAM1(7), ITGA4(19), ITGAL(17), ITGAM(13), ITGB1(3), ITGB2(7), ITK(6), JAM2(1), JAM3(4), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MLLT4(15), MMP2(7), MMP9(6), MSN(1), MYL2(4), MYL5(2), NCF1(1), NCF2(6), NCF4(3), NOX1(4), NOX3(5), OCLN(4), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PRKCA(3), PRKCG(6), PTK2(12), PTK2B(6), PTPN11(4), PXN(3), RAC1(4), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(6), RAPGEF4(9), RASSF5(2), RHOH(3), ROCK1(8), ROCK2(15), SIPA1(5), THY1(3), TXK(10), VASP(1), VAV1(8), VAV2(8), VAV3(7), VCAM1(14), VCL(4)	69466187	545	243	539	176	259	24	124	60	78	0	0.549	1.000	1.000
114	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ATF4(3), CACNA1C(14), CACNA1D(18), CACNA1F(11), CACNA1S(12), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CDC42(4), CGA(2), EGFR(7), ELK1(1), FSHB(1), GNA11(3), GNAQ(3), GNAS(12), GNRH1(3), GNRHR(2), GRB2(1), HBEGF(1), ITPR1(21), ITPR2(33), ITPR3(9), JUN(4), LHB(2), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK7(3), MAPK8(5), MAPK9(5), MMP14(4), MMP2(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLD1(9), PLD2(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCD(8), PRKX(1), PTK2B(6), RAF1(4), SOS1(23), SOS2(8), SRC(5)	72692980	546	241	534	266	263	24	123	61	75	0	1.000	1.000	1.000
115	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRA2A(3), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(4), AVPR1B(3), AVPR2(3), BDKRB1(4), BDKRB2(2), BRS3(4), C3AR1(4), CCKAR(3), CCKBR(8), CCR1(1), CCR10(3), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(4), CCR9(1), CCRL2(4), CHML(6), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CMKLR1(3), CNR1(4), CNR2(6), CX3CR1(4), CXCR3(3), CXCR4(4), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), EDNRA(4), EDNRB(8), F2R(2), F2RL1(5), F2RL2(2), F2RL3(2), FPR1(3), FSHR(5), GALR1(3), GALR2(4), GALR3(3), GALT(1), GHSR(6), GNB2L1(3), GPR17(3), GPR173(2), GPR174(4), GPR27(1), GPR35(2), GPR37(6), GPR37L1(5), GPR4(4), GPR6(5), GPR63(3), GPR83(3), GPR85(4), GPR87(3), GRPR(1), HCRTR1(1), HCRTR2(10), HRH1(9), HRH2(1), HRH3(4), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), LHCGR(7), MAS1(2), MC1R(2), MC3R(4), MC4R(3), MC5R(3), MLNR(3), MTNR1A(4), MTNR1B(1), NMBR(6), NMUR2(1), NPY1R(7), NPY2R(4), NPY5R(5), NTSR1(2), NTSR2(2), OPN1SW(3), OPN3(1), OPRD1(5), OPRK1(4), OPRL1(2), OR10A5(2), OR11A1(4), OR12D3(1), OR1C1(2), OR1F1(2), OR1Q1(2), OR2H1(3), OR5V1(5), OR7A5(6), OR7C1(6), OR8B8(3), OXTR(1), P2RY1(3), P2RY10(2), P2RY11(1), P2RY12(2), P2RY13(3), P2RY14(2), P2RY2(1), P2RY6(2), PTAFR(1), PTGDR(3), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2), RGR(3), RHO(3), RRH(4), SSTR1(3), SSTR3(4), SSTR4(6), SUCNR1(3), TRHR(9)	69978476	527	240	523	303	216	26	157	72	56	0	0.999	1.000	1.000
116	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	70	ACP1(1), ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), ACVR1B(2), ACVR1C(3), BAIAP2(5), CDC42(4), CDH1(15), CSNK2A1(11), CSNK2B(5), CTNNA1(6), CTNNA2(21), CTNNA3(11), CTNND1(10), EGFR(7), FARP2(7), FER(12), FGFR1(6), FYN(7), IGF1R(11), INSR(10), IQGAP1(11), LEF1(4), LMO7(13), MAP3K7(8), MAPK3(8), MET(19), MLLT4(15), NLK(6), PARD3(22), PTPN1(5), PTPN6(2), PTPRB(16), PTPRF(14), PTPRJ(8), PTPRM(17), PVRL1(10), PVRL2(5), PVRL3(5), PVRL4(4), RAC1(4), RAC2(1), RAC3(3), SMAD2(4), SMAD3(6), SMAD4(8), SNAI1(4), SNAI2(3), SORBS1(10), SRC(5), SSX2IP(3), TCF7(1), TCF7L2(1), TGFBR1(7), TGFBR2(8), TJP1(9), VCL(4), WAS(4), WASF1(5), WASF2(7), WASF3(5), WASL(2), YES1(6)	61445738	517	240	504	150	248	24	102	57	83	3	0.446	1.000	1.000
117	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(13), ABCA10(9), ABCA12(31), ABCA13(45), ABCA2(11), ABCA3(8), ABCA4(15), ABCA5(10), ABCA6(19), ABCA7(11), ABCA8(19), ABCA9(17), ABCB1(16), ABCB10(6), ABCB11(4), ABCB4(11), ABCB5(22), ABCB6(6), ABCB7(5), ABCB8(9), ABCB9(1), ABCC1(10), ABCC10(10), ABCC11(14), ABCC12(14), ABCC2(12), ABCC3(15), ABCC4(11), ABCC5(24), ABCC6(6), ABCC8(10), ABCC9(16), ABCD1(5), ABCD2(9), ABCD3(9), ABCD4(2), ABCG1(5), ABCG2(10), ABCG4(7), ABCG5(4), ABCG8(3), CFTR(18), TAP1(3), TAP2(1)	68236069	506	239	503	165	241	29	96	59	79	2	0.130	1.000	1.000
118	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(4), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADK(3), ADSL(4), ADSS(4), AK1(1), AK2(3), AK5(3), ALLC(3), AMPD1(10), AMPD2(6), AMPD3(4), APRT(1), ATIC(2), ATP1B1(1), ATP5A1(7), ATP5B(5), ATP5C1(4), ATP5F1(4), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5I(1), ATP5J(1), ATP5J2(2), CANT1(1), DCK(4), DGUOK(1), ENPP1(7), ENPP3(5), ENTPD1(1), ENTPD2(2), FHIT(4), GART(7), GDA(7), GMPS(5), GUCY1A2(11), GUCY1A3(12), GUCY1B3(8), GUCY2C(14), GUCY2D(6), GUCY2F(10), GUK1(3), HPRT1(1), IMPDH1(1), IMPDH2(1), ITPA(1), NME1(1), NME2(1), NPR1(8), NPR2(6), NT5C(1), NT5E(6), PAICS(4), PAPSS1(4), PAPSS2(2), PDE1A(8), PDE4A(12), PDE4B(5), PDE4C(8), PDE4D(4), PDE5A(11), PDE6B(5), PDE6C(5), PDE7B(2), PDE8A(4), PDE9A(7), PFAS(7), PKLR(8), POLD1(8), POLD2(3), POLE(27), POLG(8), POLQ(28), POLR1B(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5), PPAT(4), PRPS1(3), PRPS1L1(4), PRPS2(1), PRUNE(8), RRM1(4), RRM2(3)	74370900	544	237	535	210	264	30	120	53	75	2	0.982	1.000	1.000
119	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(2), BID(2), BRAF(9), CASP3(3), CD244(6), CD247(1), CD48(1), FAS(1), FASLG(1), FCER1G(1), FCGR3A(6), FYN(7), GRB2(1), GZMB(2), HCST(1), HLA-A(7), HLA-B(4), HLA-C(4), HLA-E(5), HLA-G(3), ICAM1(7), ICAM2(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(5), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), ITGAL(17), ITGB2(7), KIR2DL3(2), KIR3DL1(7), KIR3DL2(1), KLRC2(2), KLRC3(4), KLRD1(1), KLRK1(2), LAT(1), LCK(2), LCP2(5), MAP2K1(3), MAP2K2(5), MAPK3(8), MICA(2), MICB(3), NCR1(4), NCR2(4), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), PAK1(4), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRF1(7), PRKCA(3), PRKCG(6), PTK2B(6), PTPN11(4), PTPN6(2), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SH2D1A(1), SH2D1B(3), SH3BP2(2), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SYK(8), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFSF10(5), TYROBP(1), ULBP1(2), ULBP3(2), VAV1(8), VAV2(8), VAV3(7), ZAP70(2)	63699535	491	235	485	184	243	19	102	53	73	1	0.964	1.000	1.000
120	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(9), ACTN1(7), ACTR2(3), ACTR3(2), AKT1(3), AKT2(4), AKT3(6), ANGPTL2(3), ARHGEF6(7), ARHGEF7(9), BCAR1(6), BRAF(9), CDC42(4), CRK(4), CSE1L(12), DOCK1(11), EPHB2(10), FYN(7), GRB2(1), GRB7(1), ILK(3), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGB3BP(2), MAP2K4(4), MAP2K7(3), MAP3K11(1), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MRAS(2), MYLK(15), MYLK2(7), P4HB(6), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PIK3CB(11), PKLR(8), PLCG1(12), PLCG2(6), PTK2(12), RAF1(4), RALA(2), RHO(3), ROCK1(8), ROCK2(15), SHC1(8), SOS1(23), SOS2(8), SRC(5), TERF2IP(4), TLN1(17), TLN2(13), VASP(1), WAS(4), ZYX(4)	68727493	513	232	508	157	257	24	96	67	68	1	0.531	1.000	1.000
121	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	88	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), AKAP1(8), AKAP10(6), AKAP11(15), AKAP12(11), AKAP2(2), AKAP3(6), AKAP4(2), AKAP5(3), AKAP6(29), AKAP7(3), AKAP8(3), AKAP9(48), ARHGEF1(8), CALM1(2), CALM2(2), CHMP1B(3), GNA11(3), GNA12(3), GNA13(12), GNA14(3), GNA15(5), GNAI2(5), GNAI3(6), GNAL(4), GNAO1(2), GNAQ(3), GNAZ(3), GNB1(7), GNB3(5), GNB5(2), GNG12(2), GNG3(3), GNG4(5), GNG5(1), GNGT2(1), IL18BP(2), ITPR1(21), KCNJ3(4), PALM2(3), PDE1A(8), PDE1B(4), PDE1C(15), PDE4A(12), PDE4B(5), PDE4C(8), PDE4D(4), PDE7A(3), PDE7B(2), PDE8A(4), PDE8B(4), PLCB3(11), PPP3CA(7), PPP3CC(4), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PRKD1(12), PRKD3(13), RRAS(2), SLC9A1(7), USP5(3)	66992226	553	231	535	196	290	27	99	61	75	1	0.934	1.000	1.000
122	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(2), CALM2(2), CALML3(1), CALML6(3), CDIPT(2), CDS1(5), CDS2(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), FN3K(2), IMPA1(1), IMPA2(4), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPP5B(4), INPP5D(5), INPP5E(1), INPPL1(11), ITPK1(4), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), OCRL(4), PI4KA(11), PI4KB(13), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3C3(11), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLCD1(5), PLCD3(6), PLCD4(5), PLCE1(10), PLCG1(12), PLCG2(6), PLCZ1(5), PRKCA(3), PRKCG(6), PTPMT1(2), SYNJ1(20), SYNJ2(8)	70218166	523	231	517	201	271	23	112	47	70	0	0.977	1.000	1.000
123	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(19), AMY2A(3), AMY2B(9), ASCC3(22), ATP13A2(15), DDX18(11), DDX19A(4), DDX23(13), DDX4(12), DDX41(2), DDX47(2), DDX50(5), DDX51(2), DDX52(8), DDX54(9), DDX55(4), DHX58(3), ENPP1(7), ENPP3(5), ENTPD7(5), EP400(23), ERCC3(7), G6PC(2), G6PC2(2), GAA(5), GANC(7), GBA(4), GBE1(2), GCK(1), GPI(4), GUSB(3), GYS1(12), GYS2(13), HK1(15), HK2(11), HK3(8), IFIH1(8), LYZL1(1), MGAM(13), MOV10L1(7), NUDT5(3), PGM1(3), PGM3(1), PYGB(8), PYGL(4), PYGM(13), RAD54B(5), RAD54L(9), RUVBL2(2), SETX(27), SI(23), SKIV2L2(9), SMARCA2(23), SMARCA5(4), TREH(1), UGDH(5), UGP2(9), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), UXS1(3)	71032113	532	228	524	181	253	32	109	70	68	0	0.951	1.000	1.000
124	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(7), ACVR1B(2), ACVRL1(5), AKT1(3), AURKB(2), BMPR1A(3), BMPR2(9), BUB1(18), CDIPT(2), CDKL1(2), CDKL2(5), CDS1(5), CDS2(3), CLK1(7), CLK2(10), CLK4(3), COL4A3BP(8), CSNK2A1(11), CSNK2B(5), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), IMPA1(1), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPPL1(11), ITPKA(4), ITPKB(5), MAP3K10(2), MOS(2), NEK1(5), NEK3(4), OCRL(4), PAK4(1), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3CB(11), PIK3CG(10), PIM2(3), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLCD1(5), PLCG1(12), PLCG2(6), PLK3(10), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), PRKG1(8), RAF1(4), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA4(3), RPS6KB1(4), TGFBR1(7), VRK1(3)	63855258	517	225	512	187	251	31	94	62	77	2	0.963	1.000	1.000
125	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(3), ALG1(2), ALG10(5), ALG10B(6), ALG11(5), ALG12(3), ALG13(4), ALG14(1), ALG2(2), ALG3(1), ALG6(3), ALG8(2), ALG9(2), B3GNT1(3), B3GNT2(5), B3GNT6(1), B3GNT7(1), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), B4GALT7(1), C1GALT1(4), C1GALT1C1(3), CHPF(4), CHST1(2), CHST11(2), CHST12(3), CHST14(3), CHST2(1), CHST4(3), CHST6(1), CHST7(2), CHSY1(9), DDOST(1), DPAGT1(6), EXT1(10), EXT2(3), EXTL1(3), EXTL2(4), EXTL3(6), FUT11(2), FUT8(7), GALNT1(5), GALNT10(2), GALNT11(4), GALNT12(4), GALNT13(5), GALNT14(3), GALNT2(7), GALNT3(5), GALNT4(3), GALNT5(6), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GALNTL5(8), GANAB(16), GCNT1(5), GCNT3(3), GCNT4(5), HS2ST1(3), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), HS6ST2(2), HS6ST3(1), MAN1A1(3), MAN1A2(6), MAN1B1(9), MAN1C1(6), MAN2A1(13), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(4), MGAT5(7), MGAT5B(7), NDST1(2), NDST2(2), NDST3(7), NDST4(13), OGT(5), RPN1(3), RPN2(5), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(8), STT3B(5), UST(4), WBSCR17(9), XYLT1(6), XYLT2(6)	63726999	423	223	418	183	211	23	84	56	48	1	0.997	1.000	1.000
126	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	62	ADCY1(6), ADCY8(18), ARAF(2), ATF4(3), BRAF(9), CACNA1C(14), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), GNAQ(3), GRIA1(16), GRIA2(7), GRIN1(7), GRIN2A(14), GRIN2B(10), GRIN2C(10), GRIN2D(9), GRM1(22), GRM5(18), ITPR1(21), ITPR2(33), ITPR3(9), MAP2K1(3), MAP2K2(5), MAPK3(8), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKX(1), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF3(6), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA6(11)	51160483	422	219	414	183	198	26	94	54	50	0	0.997	1.000	1.000
127	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	77	ABL1(9), ATM(65), BUB1(18), BUB1B(11), BUB3(3), CCNA1(4), CCNA2(3), CCNB1(5), CCNB3(9), CCND2(1), CCND3(5), CCNE1(3), CCNE2(7), CCNH(4), CDAN1(6), CDC14A(5), CDC14B(10), CDC20(4), CDC25A(5), CDC25B(2), CDC25C(2), CDC6(9), CDC7(4), CDH1(15), CDK2(1), CDK4(5), CHEK1(3), CHEK2(11), DTX4(3), E2F1(3), E2F2(4), E2F3(5), E2F4(2), E2F5(3), E2F6(2), ESPL1(17), GADD45A(1), GSK3B(4), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(6), HDAC6(12), HDAC8(4), MAD1L1(3), MAD2L1(3), MAD2L2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), MPEG1(12), MPL(7), PCNA(4), PLK1(5), PRKDC(35), PTPRA(2), PTTG1(2), RBL1(9), SKP2(5), SMAD4(8), TBC1D8(7), TFDP1(2), TGFB1(2), WEE1(10)	58679171	464	216	458	137	238	19	60	53	92	2	0.519	1.000	1.000
128	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	87	AKT1(3), AKT2(4), AKT3(6), BCL10(3), CARD11(14), CBL(8), CBLB(13), CBLC(3), CD247(1), CD28(3), CD3E(2), CD3G(2), CD4(3), CD40LG(2), CD8A(2), CDC42(4), CDK4(5), CHUK(7), CTLA4(1), FOS(4), FYN(7), GRAP2(3), GRB2(1), ICOS(2), IFNG(2), IKBKB(11), IL10(1), IL2(1), IL5(1), ITK(6), JUN(4), LAT(1), LCK(2), LCP2(5), MALT1(8), MAP3K8(5), NCK1(2), NCK2(5), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PDCD1(3), PDK1(2), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRKCQ(10), PTPN6(2), PTPRC(19), RASGRP1(6), SOS1(23), SOS2(8), TEC(10), TNF(4), VAV1(8), VAV2(8), VAV3(7), ZAP70(2)	56657769	459	215	453	145	237	18	90	47	67	0	0.722	1.000	1.000
129	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	93	ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(6), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ASIP(1), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CREB3L2(5), CREB3L3(7), CREB3L4(7), DCT(8), DVL1(5), DVL2(9), DVL3(4), EDN1(2), EDNRB(8), FZD1(4), FZD10(9), FZD2(3), FZD3(6), FZD4(2), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GNAI1(4), GNAI2(5), GNAI3(6), GNAO1(2), GNAQ(3), GNAS(12), GSK3B(4), KIT(9), KITLG(5), LEF1(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MC1R(2), MITF(7), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), POMC(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(3), PRKCG(6), PRKX(1), RAF1(4), TCF7(1), TCF7L2(1), TYR(12), TYRP1(2), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(3), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2)	55778019	428	215	420	204	206	22	110	45	45	0	0.999	1.000	1.000
130	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(1), BRAF(9), CHUK(7), DAXX(9), ELK1(1), FOS(4), GRB2(1), IKBKB(11), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K5(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K11(1), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K6(9), MAP3K7(8), MAP3K8(5), MAP3K9(11), MAP4K1(8), MAP4K2(5), MAP4K3(12), MAP4K4(7), MAP4K5(4), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK4(5), MAPK6(4), MAPK7(3), MAPK8(5), MAPK9(5), MAPKAPK2(1), MAPKAPK3(3), MAPKAPK5(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MKNK1(6), MKNK2(3), MYC(2), NFKB1(3), NFKBIA(6), PAK1(4), PAK2(9), RAC1(4), RAF1(4), RELA(6), RIPK1(7), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA4(3), RPS6KA5(9), RPS6KB1(4), RPS6KB2(1), SHC1(8), SP1(10), STAT1(13), TGFB1(2), TGFB3(1), TGFBR1(7), TRADD(2), TRAF2(5)	54543081	441	213	437	158	225	20	76	46	71	3	0.977	1.000	1.000
131	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(7), ACVR1B(2), ACVR1C(3), ACVR2A(3), ACVR2B(2), ACVRL1(5), AMHR2(2), BMP2(1), BMP4(1), BMP5(6), BMP6(5), BMP7(4), BMP8B(3), BMPR1A(3), BMPR1B(4), BMPR2(9), CDKN2B(2), CHRD(7), COMP(8), CUL1(19), DCN(3), E2F4(2), E2F5(3), FST(4), GDF5(2), GDF6(4), ID1(7), ID2(1), ID3(1), IFNG(2), INHBA(3), INHBB(3), INHBC(1), INHBE(6), LEFTY2(2), LTBP1(20), MAPK3(8), MYC(2), NODAL(3), NOG(2), PITX2(5), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(3), PPP2R2C(4), RBL1(9), RBL2(9), RBX1(1), ROCK1(8), ROCK2(15), RPS6KB1(4), RPS6KB2(1), SKP1(6), SMAD1(6), SMAD2(4), SMAD3(6), SMAD4(8), SMAD6(2), SMAD7(3), SMAD9(3), SMURF1(8), SMURF2(8), SP1(10), TFDP1(2), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNF(4), ZFYVE16(14), ZFYVE9(26)	51659354	410	211	400	149	192	17	95	39	65	2	0.991	1.000	1.000
132	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(3), AKT2(4), AKT3(6), CASP8(14), CCL3(2), CCL5(1), CD14(3), CD40(3), CD80(2), CD86(6), CHUK(7), CXCL10(2), CXCL11(1), CXCL9(3), FADD(7), FOS(4), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(5), IFNB1(1), IKBKB(11), IKBKE(6), IL12A(1), IL12B(3), IL1B(3), IL6(4), IRAK1(3), IRAK4(7), IRF3(5), IRF5(4), IRF7(3), JUN(4), LBP(2), LY96(1), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K7(8), MAP3K8(5), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK8(5), MAPK9(5), MYD88(1), NFKB1(3), NFKB2(3), NFKBIA(6), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), RAC1(4), RELA(6), RIPK1(7), SPP1(2), STAT1(13), TBK1(7), TICAM1(9), TLR1(3), TLR2(3), TLR3(10), TLR4(6), TLR5(11), TLR6(6), TLR7(9), TLR8(9), TLR9(6), TNF(4), TOLLIP(3), TRAF3(2), TRAF6(1)	50698207	403	209	398	136	213	19	72	36	62	1	0.699	1.000	1.000
133	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	90	CD2BP2(8), CDC40(2), CLK2(10), CLK3(2), CLK4(3), COL2A1(14), CPSF1(9), CPSF2(3), CPSF3(8), CPSF4(3), CSTF1(2), CSTF2(6), CSTF2T(5), CSTF3(4), DDIT3(1), DDX1(8), DDX20(10), DHX15(12), DHX16(9), DHX38(6), DHX8(12), DHX9(21), DICER1(19), DNAJC8(1), FUS(9), GIPC1(2), LSM2(2), LSM7(1), NCBP1(2), NCBP2(1), NONO(4), NUDT21(1), NXF1(10), PABPN1(4), PAPOLA(10), PHF5A(2), POLR2A(13), PPM1G(10), PRPF18(6), PRPF3(10), PRPF4(5), PRPF4B(8), PRPF8(8), PSKH1(3), PTBP1(2), PTBP2(8), RBM17(11), RBM5(12), RNGTT(4), RNMT(4), RNPS1(1), SF3A1(6), SF3A3(7), SF3B2(5), SF3B4(3), SF3B5(2), SNRPA(6), SNRPA1(3), SNRPB(8), SNRPB2(3), SNRPD1(1), SNRPD2(1), SNRPD3(1), SNRPE(2), SNRPG(2), SNRPN(5), SPOP(6), SRPK1(2), SRPK2(6), SRRM1(5), SUPT5H(11), U2AF1(8), U2AF2(4), XRN2(7)	59176586	435	208	426	139	234	27	73	36	64	1	0.986	1.000	1.000
134	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(4), AKT1(3), AKT2(4), AKT3(6), APAF1(7), ATM(65), BAD(2), BAX(1), BCL2L1(4), BID(2), BIRC2(3), BIRC3(3), CAPN1(5), CAPN2(2), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CSF2RB(5), CYCS(1), DFFA(6), FADD(7), FAS(1), FASLG(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1RAP(5), IL3RA(6), IRAK1(3), IRAK2(5), IRAK3(9), IRAK4(7), MYD88(1), NFKB1(3), NFKB2(3), NFKBIA(6), NTRK1(6), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RELA(6), RIPK1(7), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFRSF1A(5), TNFSF10(5), TRADD(2), TRAF2(5)	46609910	381	207	374	123	195	17	60	34	74	1	0.775	1.000	1.000
135	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	65	A2M(15), BDKRB1(4), BDKRB2(2), C1QA(3), C1R(2), C1S(8), C2(5), C3(16), C3AR1(4), C4BPA(8), C4BPB(3), C5(9), C5AR1(3), C6(9), C7(4), C8A(7), C8B(3), C8G(2), C9(8), CD46(6), CD55(2), CFB(6), CFH(13), CFI(3), CPB2(5), CR1(14), CR2(17), F10(5), F11(10), F12(3), F13A1(8), F13B(9), F2(3), F2R(2), F5(24), F7(8), F8(22), F9(3), FGA(17), FGB(5), FGG(7), KLKB1(2), KNG1(5), MASP1(8), MASP2(5), MBL2(1), PLAT(6), PLAUR(7), PLG(4), PROC(2), SERPINA1(1), SERPINA5(5), SERPINC1(7), SERPIND1(6), SERPINE1(6), SERPING1(3), THBD(4), VWF(21)	51673384	400	206	394	145	182	22	100	47	49	0	0.967	1.000	1.000
136	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(6), CD14(3), CD19(4), CD1A(7), CD1B(3), CD1C(2), CD1D(14), CD1E(12), CD2(2), CD22(4), CD33(6), CD34(3), CD36(2), CD37(1), CD38(1), CD3E(2), CD3G(2), CD4(3), CD44(2), CD5(3), CD55(2), CD7(3), CD8A(2), CD9(3), CR1(14), CR2(17), CSF1(4), CSF1R(11), CSF2RA(7), CSF3(1), CSF3R(4), DNTT(11), EPO(2), EPOR(5), FCGR1A(2), FLT3(10), FLT3LG(1), GP5(1), GP9(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), IL11RA(2), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), IL2RA(1), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL7(1), IL7R(7), IL9R(3), ITGA1(7), ITGA2(6), ITGA2B(13), ITGA3(7), ITGA4(19), ITGA5(8), ITGA6(9), ITGAM(13), ITGB3(9), KIT(9), KITLG(5), MME(13), MS4A1(5), TFRC(9), THPO(4), TNF(4), TPO(16)	47265011	394	204	392	130	157	20	104	55	58	0	0.630	1.000	1.000
137	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	88	ACTB(20), BAD(2), CABIN1(10), CALM1(2), CALM2(2), CAMK2B(5), CAMK4(4), CD3E(2), CD3G(2), CEBPB(3), CNR1(4), CSNK2A1(11), CSNK2B(5), CTLA4(1), EGR2(3), EGR3(3), FCER1A(5), FCGR3A(6), FOS(4), FOSL1(3), GATA3(8), GATA4(1), GSK3A(2), GSK3B(4), ICOS(2), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL1B(3), IL2(1), IL2RA(1), IL6(4), ITK(6), JUNB(5), KPNA5(5), MAP2K7(3), MAPK14(2), MAPK8(5), MAPK9(5), MEF2A(7), MEF2B(3), MEF2D(3), MYF5(9), NCK2(5), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NFKB2(3), NFKBIB(6), NFKBIE(7), NPPB(1), NUP214(17), OPRD1(5), P2RX7(5), PAK1(4), PPIA(1), PPP3CB(6), PPP3CC(4), PPP3R1(1), PTPRC(19), RELA(6), SFN(1), SLA(2), SP1(10), SP3(3), TGFB1(2), TNF(4), TRAF2(5), TRPV6(5), VAV1(8), VAV2(8), VAV3(7), XPO5(10)	46775530	392	202	387	136	187	18	85	34	68	0	0.879	1.000	1.000
138	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	59	AKT1(3), AKT2(4), AKT3(6), BAD(2), BCL2L1(4), CDC42(4), CDK2(1), CDKN1B(6), CREB5(10), EBP(1), ERBB4(11), F2RL2(2), GAB1(6), GADD45A(1), GRB2(1), GSK3A(2), GSK3B(4), IGF1(2), IGFBP1(4), INPPL1(11), IRS1(9), IRS2(5), IRS4(18), MET(19), MYC(2), NOLC1(3), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PARD3(22), PARD6A(7), PDK1(2), PIK3CD(7), PPP1R13B(7), PREX1(14), PTK2(12), PTPN1(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(8), SLC2A4(4), SOS1(23), SOS2(8), TSC2(11), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6)	41462596	352	200	347	103	171	12	79	34	53	3	0.488	1.000	1.000
139	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(11), APAF1(7), ARHGDIB(1), BAG4(4), BID(2), BIRC2(3), BIRC3(3), CASP2(2), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CRADD(1), CYCS(1), DAXX(9), DFFA(6), FADD(7), GSN(2), LMNA(5), LMNB1(4), LMNB2(7), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK8(5), MDM2(6), NFKB1(3), NFKBIA(6), NUMA1(14), PAK2(9), PRKCD(8), PRKDC(35), PSEN1(8), PSEN2(2), PTK2(12), RASA1(8), RELA(6), RIPK1(7), SPTAN1(68), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5)	38965117	359	199	356	113	198	16	53	17	75	0	0.848	1.000	1.000
140	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(20), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(5), ACSL6(1), ADIPOQ(2), ADIPOR1(8), ADIPOR2(1), AGRP(2), AKT1(3), AKT2(4), AKT3(6), CAMKK1(3), CAMKK2(5), CD36(2), CHUK(7), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), G6PC(2), G6PC2(2), IKBKB(11), IRS1(9), IRS2(5), IRS4(18), JAK1(9), JAK2(8), JAK3(12), LEP(1), LEPR(8), MAPK10(9), MAPK8(5), MAPK9(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NPY(2), PCK1(9), PCK2(2), POMC(1), PPARA(1), PPARGC1A(18), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKAG1(3), PRKCQ(10), PTPN11(4), RELA(6), RXRB(3), RXRG(8), SLC2A1(4), SLC2A4(4), SOCS3(1), STAT3(6), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5), TYK2(9)	47548155	364	199	361	119	175	18	78	35	58	0	0.523	1.000	1.000
141	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(35), ASH2L(1), CARM1(6), CTCFL(4), DOT1L(21), EED(5), EHMT1(8), EHMT2(12), EZH1(6), EZH2(6), FBXO11(6), HCFC1(4), HSF4(4), JMJD4(3), JMJD6(3), MEN1(3), NSD1(23), OGT(5), PAXIP1(8), PPP1CA(8), PPP1CB(4), PPP1CC(2), PRDM2(18), PRDM7(5), PRDM9(13), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), RBBP5(4), SATB1(6), SETD1A(9), SETD2(32), SETD7(3), SETD8(3), SETDB1(14), SETDB2(3), SETMAR(2), SMYD3(3), STK38(7), SUV39H2(1), SUV420H1(19), SUV420H2(2), SUZ12(9), WHSC1(17), WHSC1L1(15)	67467511	385	194	379	127	224	12	56	45	48	0	0.992	1.000	1.000
142	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	60	ATM(65), CCNA1(4), CCNB1(5), CCND1(4), CCND2(1), CCND3(5), CCNE1(3), CCNE2(7), CCNG2(4), CCNH(4), CDC25A(5), CDK2(1), CDK4(5), CDK7(6), CDKN1B(6), CDKN2B(2), CDKN2C(2), CDKN2D(1), CREB3L3(7), CREB3L4(7), E2F1(3), E2F2(4), E2F3(5), E2F4(2), E2F5(3), E2F6(2), GADD45A(1), GBA2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), MNAT1(4), MYC(2), MYT1(10), NACA(14), PCNA(4), POLA2(11), POLE(27), POLE2(4), RBL1(9), RPA2(1), RPA3(4), TFDP1(2), TFDP2(5), TNXB(38), WEE1(10)	42785091	352	192	344	106	182	17	61	32	59	1	0.610	1.000	1.000
143	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(3), AKT2(4), AKT3(6), BAD(2), BCR(3), BLNK(8), BTK(5), CD19(4), CD22(4), CD81(2), CR2(17), CSK(7), DAG1(3), FLOT1(3), FLOT2(5), GRB2(1), GSK3A(2), GSK3B(4), INPP5D(5), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), MAP4K1(8), MAPK3(8), NFATC1(13), NFATC2(13), NR0B2(2), PDK1(2), PIK3CD(7), PIK3R1(6), PLCG2(6), PPP1R13B(7), PPP3CA(7), PPP3CB(6), PPP3CC(4), PTPRC(19), RAF1(4), SHC1(8), SOS1(23), SOS2(8), SYK(8), VAV1(8)	41679630	323	189	321	123	159	19	67	33	45	0	0.944	1.000	1.000
144	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(3), AKT2(4), AKT3(6), BAD(2), CASP9(6), CDC42(4), KDR(19), MAP2K1(3), MAP2K2(5), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPKAPK2(1), MAPKAPK3(3), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NOS3(11), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCG1(12), PLCG2(6), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PRKCA(3), PRKCG(6), PTGS2(6), PTK2(12), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SH2D2A(6), SHC2(3), SPHK1(1), SPHK2(10), SRC(5), VEGFA(4)	39635551	320	188	318	107	150	16	71	33	50	0	0.695	1.000	1.000
145	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	58	AKT1(3), AKT2(4), AKT3(6), BCL10(3), BLNK(8), BTK(5), CARD11(14), CD19(4), CD22(4), CD72(2), CD79A(4), CD79B(2), CD81(2), CHUK(7), CR2(17), FCGR2B(2), FOS(4), GSK3B(4), IKBKB(11), INPP5D(5), JUN(4), LILRB3(12), LYN(5), MALT1(8), NFAT5(15), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG2(6), PPP3CA(7), PPP3CB(6), PPP3CC(4), PPP3R1(1), PTPN6(2), RAC1(4), RAC2(1), RAC3(3), RASGRP3(5), SYK(8), VAV1(8), VAV2(8), VAV3(7)	41107140	337	183	333	105	157	19	68	34	59	0	0.542	1.000	1.000
146	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(14), ADAM17(7), ATP6AP1(3), ATP6V0A1(12), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), CASP3(3), CCL5(1), CDC42(4), CHUK(7), CSK(7), CXCL1(1), EGFR(7), F11R(5), GIT1(6), HBEGF(1), IGSF5(4), IKBKB(11), JAM2(1), JAM3(4), JUN(4), LYN(5), MAP2K4(4), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK8(5), MAPK9(5), MET(19), NFKB1(3), NFKB2(3), NFKBIA(6), NOD1(6), PAK1(4), PLCG1(12), PLCG2(6), PTPN11(4), PTPRZ1(20), RAC1(4), RELA(6), SRC(5), TCIRG1(6), TJP1(9)	40872207	324	182	319	86	171	13	68	26	46	0	0.108	1.000	1.000
147	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(4), ALG6(3), CCKBR(8), CCR3(3), CCR5(6), CELSR1(20), CELSR2(18), CELSR3(29), CHRM2(5), CHRM3(8), CIDEB(2), CXCR3(3), DRD4(1), EDNRA(4), EMR2(6), EMR3(4), F2R(2), FSHR(5), GHRHR(3), GNRHR(2), GPR116(10), GPR132(4), GPR133(12), GPR135(2), GPR143(1), GPR17(3), GPR18(3), GPR55(2), GPR56(7), GPR61(7), GPR84(2), GPR88(3), GRM1(22), GRPR(1), HRH4(3), LGR6(8), LPHN2(21), LPHN3(21), LTB4R2(3), NTSR1(2), OR2M4(3), P2RY11(1), P2RY13(3), PTGFR(7), SMO(8), TAAR5(2), TSHR(8), VN1R1(1)	38569589	306	178	299	142	126	15	86	40	38	1	0.909	1.000	1.000
148	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(4), ACADL(2), ACADM(1), ACOX1(6), ACOX2(9), ACOX3(7), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(5), ACSL6(1), ADIPOQ(2), ANGPTL4(6), APOA1(2), APOA2(4), APOA5(4), APOC3(1), AQP7(7), CD36(2), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), CYP27A1(9), CYP4A11(5), CYP4A22(7), CYP7A1(10), CYP8B1(5), DBI(2), EHHADH(6), FABP1(2), FABP2(1), FABP5(1), FABP6(1), FADS2(2), GK(2), GK2(6), HMGCS2(7), ILK(3), LPL(4), ME1(5), MMP1(3), NR1H3(3), PCK1(9), PCK2(2), PDPK1(2), PLTP(6), PPARA(1), PPARD(6), PPARG(13), RXRB(3), RXRG(8), SCD(2), SCP2(4), SLC27A1(6), SLC27A2(10), SLC27A4(2), SLC27A5(9), SLC27A6(6), SORBS1(10), UBC(9), UCP1(4)	37446194	292	178	283	104	142	14	73	23	40	0	0.744	1.000	1.000
149	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(7), ATM(65), ATR(32), BAI1(5), BAX(1), BID(2), CASP3(3), CASP8(14), CASP9(6), CCNB1(5), CCNB3(9), CCND1(4), CCND2(1), CCND3(5), CCNE1(3), CCNE2(7), CCNG1(2), CCNG2(4), CD82(3), CDK2(1), CDK4(5), CDK6(5), CHEK1(3), CHEK2(11), CYCS(1), DDB2(8), EI24(1), FAS(1), GADD45A(1), GADD45G(1), GTSE1(5), IGF1(2), IGFBP3(1), MDM2(6), MDM4(2), PERP(2), PPM1D(5), RCHY1(2), RFWD2(6), RPRM(3), RRM2(3), RRM2B(2), SERPINB5(3), SERPINE1(6), SESN1(8), SESN2(2), SESN3(11), SFN(1), SIAH1(2), STEAP3(3), THBS1(8), TNFRSF10B(6), TP53I3(4), TP73(6), TSC2(11), ZMAT3(3)	36359642	329	178	320	101	174	17	53	32	51	2	0.754	1.000	1.000
150	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(15), CANT1(1), CDA(1), CTPS2(3), DCK(4), DCTD(2), DHODH(2), DPYD(14), DPYS(13), DUT(2), ENTPD1(1), ENTPD3(5), ENTPD5(4), ENTPD6(2), ENTPD8(5), ITPA(1), NME1(1), NME2(1), NME4(1), NME6(1), NME7(3), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), PNPT1(10), POLA1(8), POLA2(11), POLD1(8), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLR1A(18), POLR1B(4), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2), PRIM2(1), RFC5(5), RRM1(4), RRM2(3), RRM2B(2), TK1(2), TXNRD1(6), TXNRD2(1), TYMS(3), UCK1(2), UMPS(4), UPB1(4), UPP2(3), UPRT(5)	47018508	314	174	312	129	168	19	50	36	40	1	0.995	1.000	1.000
151	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(3), AKT2(4), AKT3(6), BRD4(14), CAP1(7), CBL(8), CDC42(4), F2RL2(2), FLOT1(3), FLOT2(5), GRB2(1), GSK3A(2), GSK3B(4), IGFBP1(4), INPPL1(11), IRS1(9), IRS2(5), IRS4(18), LNPEP(7), MAPK3(8), PARD3(22), PARD6A(7), PDK1(2), PIK3CD(7), PIK3R1(6), PTPN1(5), RAF1(4), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KB1(4), SERPINB6(4), SFN(1), SHC1(8), SLC2A4(4), SORBS1(10), SOS1(23), SOS2(8), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6)	32550034	283	173	279	88	152	10	50	32	36	3	0.678	1.000	1.000
152	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(2), IMPA1(1), IMPA2(4), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPP5B(4), INPP5E(1), INPPL1(11), IPMK(2), ISYNA1(2), ITPK1(4), ITPKA(4), ITPKB(5), MINPP1(5), OCRL(4), PI4KA(11), PI4KB(13), PIK3C3(11), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLCD1(5), PLCD3(6), PLCD4(5), PLCE1(10), PLCG1(12), PLCG2(6), PLCZ1(5), PTPMT1(2), SYNJ1(20), SYNJ2(8)	41328880	291	172	287	112	157	9	67	29	29	0	0.928	1.000	1.000
153	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(2), BAK1(2), BAX(1), BFAR(7), BTK(5), CAD(15), CASP10(1), CASP3(3), CASP8(14), CD7(3), CSNK1A1(6), DAXX(9), DEDD(5), DFFA(6), DIABLO(3), EGFR(7), EPHB2(10), FADD(7), FAF1(4), HSPB1(1), IL1A(1), MAP2K4(4), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MET(19), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NR0B2(2), PFN1(4), PFN2(1), PTPN13(19), RALBP1(2), RIPK1(7), ROCK1(8), SMPD1(4), TNFRSF6B(1), TPX2(7), TRAF2(5)	41511088	298	171	295	100	155	8	66	26	43	0	0.870	1.000	1.000
154	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(7), BAD(2), BAK1(2), BAX(1), BCL2L1(4), BCL2L11(3), BID(2), BIRC2(3), BIRC3(3), BIRC5(2), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CHUK(7), CYCS(1), DFFA(6), FADD(7), FAS(1), FASLG(1), GZMB(2), HELLS(5), IKBKB(11), IRF1(1), IRF2(6), IRF3(5), IRF4(3), IRF5(4), IRF6(4), IRF7(3), JUN(4), LTA(1), MAP2K4(4), MAP3K1(10), MAPK10(9), MDM2(6), MYC(2), NFKB1(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PLEKHG5(6), PRF1(7), RELA(6), RIPK1(7), TNF(4), TNFRSF10B(6), TNFRSF1A(5), TNFRSF1B(6), TNFRSF21(5), TNFRSF25(3), TNFSF10(5), TP73(6), TRADD(2), TRAF2(5), TRAF3(2)	32709446	275	169	268	92	151	14	49	20	41	0	0.818	1.000	1.000
155	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(3), AKT2(4), AKT3(6), BTK(5), FCER1A(5), FCER1G(1), FYN(7), GAB2(8), GRB2(1), IL5(1), INPP5D(5), LAT(1), LCP2(5), LYN(5), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK8(5), MAPK9(5), MS4A2(6), PDK1(2), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCG1(12), PLCG2(6), PRKCA(3), PRKCD(8), PRKCE(5), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SOS1(23), SOS2(8), SYK(8), TNF(4), VAV1(8), VAV2(8), VAV3(7)	39722185	308	169	306	120	150	10	67	43	38	0	0.975	1.000	1.000
156	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(4), AANAT(2), ACAT1(5), ACAT2(1), ACMSD(2), AFMID(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), AOX1(8), ASMT(1), CARM1(6), CAT(9), CYP1A1(2), CYP1A2(4), CYP1B1(3), DDC(8), ECHS1(1), EHHADH(6), GCDH(5), HAAO(1), HADH(5), HADHA(4), HEMK1(1), HSD17B10(1), HSD17B4(5), INMT(1), KMO(1), KYNU(1), LCMT1(2), LCMT2(12), LNX1(4), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), NFX1(8), OGDH(21), OGDHL(10), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), TDO2(3), TPH1(3), TPH2(4), WARS(5), WARS2(2), WBSCR22(6)	35180634	243	167	235	76	127	10	45	24	37	0	0.411	1.000	1.000
157	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(3), ACTR3(2), AKT1(3), AKT2(4), AKT3(6), ANGPTL2(3), ARHGAP1(1), ARHGAP4(3), ARHGEF11(10), BTK(5), CDC42(4), CFL1(1), CFL2(4), GDI1(3), GDI2(5), INPPL1(11), ITPR1(21), ITPR2(33), ITPR3(9), LIMK1(6), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PDK1(2), PIK3CD(7), PIK3CG(10), PIK3R1(6), PITX2(5), PPP1R13B(7), RACGAP1(6), RHO(3), ROCK1(8), ROCK2(15), RPS4X(4), SAG(2), WASF1(5), WASL(2)	39011902	274	167	270	97	144	11	50	31	38	0	0.864	1.000	1.000
158	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	ADAM17(7), APH1A(3), CTBP1(4), CTBP2(7), DLL1(9), DLL3(4), DLL4(5), DTX1(5), DTX2(6), DTX3(4), DTX3L(9), DTX4(3), DVL1(5), DVL2(9), DVL3(4), HDAC1(4), HDAC2(3), HES1(12), JAG1(13), JAG2(1), LFNG(2), MAML1(3), MAML2(6), MAML3(5), NCOR2(19), NCSTN(10), NOTCH1(17), NOTCH2(11), NOTCH3(12), NOTCH4(14), NUMB(3), NUMBL(1), PSEN1(8), PSEN2(2), RBPJ(3), RBPJL(5), RFNG(1), SNW1(8)	34034948	247	165	244	91	116	11	58	19	41	2	0.899	1.000	1.000
159	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(29), AXIN1(4), CCND1(4), CCND2(1), CCND3(5), CSNK1E(3), DVL1(5), DVL2(9), DVL3(4), FBXW2(5), FOSL1(3), FZD1(4), FZD10(9), FZD2(3), FZD3(6), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GSK3B(4), JUN(4), LDLR(10), MAPK10(9), MAPK9(5), MYC(2), PAFAH1B1(2), PPP2R5C(6), PPP2R5E(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PRKD1(12), RAC1(4), SFRP4(5), TCF7(1), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1)	33619154	273	165	267	104	145	15	48	21	44	0	0.890	1.000	1.000
160	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(18), ATP4A(5), ATP4B(2), ATP5A1(7), ATP5B(5), ATP5C1(4), ATP5E(1), ATP5F1(4), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5I(1), ATP5J(1), ATP5J2(2), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), COX10(4), COX15(4), COX17(2), COX4I2(1), COX5A(5), COX6A1(5), COX6C(2), COX7A1(1), COX7A2(1), COX7B(1), COX7B2(3), COX8A(1), CYC1(7), LHPP(2), NDUFA1(1), NDUFA10(4), NDUFA12(1), NDUFA13(1), NDUFA5(1), NDUFA6(2), NDUFA7(2), NDUFA8(4), NDUFA9(4), NDUFAB1(2), NDUFB10(2), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFB9(3), NDUFS1(5), NDUFS2(3), NDUFS3(1), NDUFS4(3), NDUFS6(1), NDUFS7(3), NDUFS8(1), NDUFV1(4), NDUFV2(6), PPA1(1), PPA2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(3), TCIRG1(6), UQCRB(1), UQCRC1(2), UQCRC2(4), UQCRFS1(3), UQCRH(2)	32357592	279	164	273	87	140	12	57	30	40	0	0.399	1.000	1.000
161	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(9), ACTB(20), ACTG1(11), ARHGEF2(7), ARPC5(5), CD14(3), CDC42(4), CDH1(15), CLDN1(3), CTTN(9), EZR(12), FYN(7), HCLS1(5), ITGB1(3), KRT18(5), LY96(1), NCK1(2), NCK2(5), NCL(3), OCLN(4), PRKCA(3), ROCK1(8), ROCK2(15), TLR4(6), TLR5(11), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(3), WAS(4), WASL(2), YWHAQ(3), YWHAZ(6)	29477756	251	163	245	81	131	10	53	21	35	1	0.736	1.000	1.000
162	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(9), ACTB(20), ACTG1(11), ARHGEF2(7), ARPC5(5), CD14(3), CDC42(4), CDH1(15), CLDN1(3), CTTN(9), EZR(12), FYN(7), HCLS1(5), ITGB1(3), KRT18(5), LY96(1), NCK1(2), NCK2(5), NCL(3), OCLN(4), PRKCA(3), ROCK1(8), ROCK2(15), TLR4(6), TLR5(11), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(3), WAS(4), WASL(2), YWHAQ(3), YWHAZ(6)	29477756	251	163	245	81	131	10	53	21	35	1	0.736	1.000	1.000
163	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(45), B3GALT4(6), CDR1(4), DGKI(9), IL6ST(9), MRPL19(2), PIGK(4), RPL10(3), RPL11(2), RPL13(3), RPL15(3), RPL17(4), RPL19(2), RPL23(4), RPL24(3), RPL26(4), RPL28(2), RPL29(2), RPL3(1), RPL30(1), RPL31(5), RPL34(2), RPL35A(1), RPL36(1), RPL37(1), RPL3L(3), RPL4(5), RPL41(1), RPL5(3), RPL6(2), RPL7(3), RPL8(2), RPL9(1), RPLP0(3), RPLP2(1), RPS10(1), RPS12(3), RPS13(2), RPS15(1), RPS16(1), RPS18(6), RPS19(1), RPS2(6), RPS20(2), RPS24(1), RPS26(1), RPS27A(1), RPS29(1), RPS3A(1), RPS4X(4), RPS4Y1(1), RPS5(1), RPS6(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA6(11), RPS6KB1(4), RPS6KB2(1), RPS7(2), RPS8(2), RPS9(2), RPSA(4), SLC36A2(1), TBC1D10C(5), TSPAN9(2), UBA52(7), UBC(9)	30355677	259	162	254	100	131	19	54	25	29	1	0.935	1.000	1.000
164	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1C1(2), AKR1C2(1), AKR1C3(3), AKR1C4(5), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), CYP1A1(2), CYP1A2(4), CYP1B1(3), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(3), CYP2E1(4), CYP2F1(4), CYP2S1(2), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), DHDH(3), EPHX1(5), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(3), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(4), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), MGST1(1), MGST2(1), MGST3(1), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2)	33419411	248	160	247	88	119	14	48	28	39	0	0.669	1.000	1.000
165	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(4), AKT3(6), ASAH1(4), BRAF(9), DAG1(3), DRD2(5), EGFR(7), EPHB2(10), GRB2(1), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), PI3(1), PIK3CB(11), PITX2(5), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), RAF1(4), RGS20(3), SHC1(8), SOS1(23), SOS2(8), SRC(5), STAT3(6), TERF2IP(4)	34007869	253	159	248	98	132	9	52	30	30	0	0.937	1.000	1.000
166	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(1), BMP5(6), BMP6(5), BMP7(4), BMP8B(3), BTRC(4), CSNK1A1(6), CSNK1A1L(4), CSNK1D(3), CSNK1E(3), CSNK1G1(6), CSNK1G2(6), CSNK1G3(3), FBXW11(1), GLI1(10), GLI2(16), GLI3(19), GSK3B(4), HHIP(9), IHH(3), LRP2(45), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(1), PTCH1(19), PTCH2(5), RAB23(2), SHH(6), SMO(8), STK36(11), SUFU(2), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(3), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2), ZIC2(7)	35144072	270	158	267	111	114	13	76	22	45	0	0.984	1.000	1.000
167	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(65), ATR(32), BRCA1(23), BRCA2(47), CHEK1(3), CHEK2(11), FANCA(18), FANCC(9), FANCD2(19), FANCE(3), FANCF(4), FANCG(5), HUS1(1), MRE11A(7), RAD1(3), RAD17(6), RAD50(13), RAD51(7), RAD9A(2), TREX1(8)	25324274	286	157	279	45	147	18	40	33	45	3	0.00614	1.000	1.000
168	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(5), ALPL(4), ALPP(3), ASCC3(22), ATP13A2(15), DDX18(11), DDX19A(4), DDX23(13), DDX4(12), DDX41(2), DDX47(2), DDX50(5), DDX51(2), DDX52(8), DDX54(9), DDX55(4), DHX58(3), ENTPD7(5), EP400(23), ERCC3(7), FPGS(4), GCH1(1), GGH(3), IFIH1(8), MOV10L1(7), NUDT5(3), QDPR(3), RAD54B(5), RAD54L(9), RUVBL2(2), SETX(27), SKIV2L2(9), SMARCA2(23), SMARCA5(4)	35583173	267	155	264	95	135	12	59	32	29	0	0.929	1.000	1.000
169	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(6), ADCY6(15), ADCY8(18), CACNA1A(25), CACNA1B(17), GNAS(12), GNAT3(2), GNB1(7), GNB3(5), GNG3(3), GRM4(9), ITPR3(9), KCNB1(8), PDE1A(8), PLCB2(6), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(1), SCNN1A(11), SCNN1B(6), SCNN1G(5), TAS1R1(2), TAS1R2(7), TAS1R3(20), TAS2R1(1), TAS2R13(2), TAS2R14(1), TAS2R16(4), TAS2R3(3), TAS2R39(3), TAS2R4(1), TAS2R40(2), TAS2R41(3), TAS2R43(1), TAS2R46(3), TAS2R5(1), TAS2R50(3), TAS2R60(5), TAS2R7(1), TAS2R8(1), TAS2R9(6), TRPM5(3)	32728290	252	155	239	121	139	15	57	22	19	0	0.886	1.000	1.000
170	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(19), AMY2A(3), AMY2B(9), ENPP1(7), ENPP3(5), G6PC(2), GAA(5), GANAB(16), GBE1(2), GCK(1), GPI(4), GUSB(3), GYS1(12), GYS2(13), HK1(15), HK2(11), HK3(8), MGAM(13), PGM1(3), PGM3(1), PYGB(8), PYGL(4), PYGM(13), RNPC3(1), SI(23), UCHL1(3), UCHL3(3), UGDH(5), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4), UXS1(3)	33041540	257	155	255	93	115	17	56	32	37	0	0.925	1.000	1.000
171	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(34), EEF1A2(3), EEF1B2(2), EEF1D(1), EEF1G(4), EEF2(5), EEF2K(7), EIF2AK1(5), EIF2AK2(7), EIF2AK3(12), EIF2B1(1), EIF2B2(5), EIF2B3(1), EIF2B4(10), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF4A1(4), EIF4A2(11), EIF4E(2), EIF4EBP1(1), EIF4EBP2(3), EIF4G1(17), EIF4G3(27), EIF5(9), EIF5A(5), EIF5B(11), ETF1(2), GSPT2(6), PABPC1(7), PABPC3(8), PAIP1(11), SLC35A4(3)	25401472	247	153	244	52	124	11	47	28	37	0	0.0807	1.000	1.000
172	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CFLAR(2), DAXX(9), DFFA(6), FADD(7), FAF1(4), JUN(4), LMNA(5), LMNB1(4), LMNB2(7), MAP2K4(4), MAP3K1(10), MAP3K7(8), MAPK8(5), PAK1(4), PAK2(9), PRKDC(35), PTPN13(19), RIPK2(5), SPTAN1(68)	22415835	240	151	236	70	125	8	32	12	62	1	0.836	1.000	1.000
173	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(3), BDKRB2(2), CALM1(2), CALM2(2), CHRM1(2), CHRNA1(2), FLT1(8), FLT4(10), KDR(19), NOS3(11), PDE2A(2), PDE3A(11), PDE3B(9), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKG1(8), PRKG2(8), RYR2(83), SLC7A1(8), SYT1(6), TNNI1(5)	23210929	225	151	224	92	92	13	55	33	31	1	0.979	1.000	1.000
174	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(8), CARM1(6), COMT(3), DBH(4), DCT(8), DDC(8), ECH1(7), ESCO1(3), ESCO2(3), FAH(3), GOT1(2), GSTZ1(2), HEMK1(1), HGD(4), HPD(4), LCMT1(2), LCMT2(12), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), MIF(1), NAT6(1), PNPLA3(4), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SH3GLB1(1), TAT(5), TH(2), TPO(16), TYR(12), TYRP1(2), WBSCR22(6)	34515087	223	149	219	63	104	7	57	24	31	0	0.203	1.000	1.000
175	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(9), CPEB1(7), EGFR(7), ERBB4(11), ETS1(5), ETS2(5), ETV6(12), ETV7(4), FMN2(26), GRB2(1), MAP2K1(3), MAPK3(8), NOTCH1(17), NOTCH2(11), NOTCH3(12), NOTCH4(14), PIWIL1(12), PIWIL2(8), PIWIL3(6), PIWIL4(8), RAF1(4), SOS1(23), SOS2(8), SPIRE1(2), SPIRE2(9)	28449320	232	149	227	71	110	11	46	29	34	2	0.720	1.000	1.000
176	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(5), AKR1D1(5), ARSD(7), ARSE(2), CARM1(6), CYP11B1(4), CYP11B2(13), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(1), HSD17B12(3), HSD17B2(6), HSD17B3(1), HSD17B7(3), HSD17B8(4), HSD3B1(5), HSD3B2(5), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SRD5A1(4), STS(5), SULT1E1(1), SULT2A1(4), SULT2B1(2), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), WBSCR22(6)	29200143	218	148	213	64	108	12	48	30	20	0	0.258	1.000	1.000
177	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(4), AASS(11), ACAT1(5), ACAT2(1), AKR1B10(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), BBOX1(4), DLST(1), DOT1L(21), ECHS1(1), EHHADH(6), EHMT1(8), EHMT2(12), GCDH(5), HADH(5), HADHA(4), HSD17B10(1), HSD17B4(5), HSD3B7(2), NSD1(23), OGDH(21), OGDHL(10), PIPOX(4), PLOD1(3), PLOD2(5), PLOD3(5), RDH12(2), RDH13(1), SETD1A(9), SETD7(3), SETDB1(14), SHMT1(3), SHMT2(2), SPCS3(1), SUV39H2(1), TMLHE(2)	33573987	228	147	222	115	128	9	40	19	32	0	1.000	1.000	1.000
178	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AGK(1), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), AKR1A1(2), AKR1B1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), CEL(8), DAK(4), DGAT1(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), GK(2), GK2(6), GLA(3), GLB1(5), GPAM(5), LCT(16), LIPA(3), LIPC(6), LIPF(6), LIPG(4), LPL(4), MGLL(2), PNLIP(5), PNLIPRP1(8), PNPLA3(4), PPAP2A(5), PPAP2B(3), PPAP2C(1)	33796651	252	147	250	89	120	14	53	25	40	0	0.618	1.000	1.000
179	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(3), ASAH1(4), ATF1(2), BRAF(9), CAMP(1), CREB5(10), CRKL(1), DAG1(3), EGR1(7), EGR2(3), EGR3(3), EGR4(5), ELK1(1), FRS2(10), GNAQ(3), JUN(4), MAP1B(19), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), NTRK1(6), OPN1LW(5), PIK3C2G(11), PIK3CD(7), PIK3R1(6), PTPN11(4), RPS6KA3(8), SHC1(8), SRC(5), TERF2IP(4), TH(2)	25559824	205	147	203	67	102	12	50	20	21	0	0.660	1.000	1.000
180	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(6), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), CDIPT(2), CDS1(5), CDS2(3), CHAT(4), CHKA(5), CHKB(4), CHPT1(6), CRLS1(1), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), ESCO1(3), ESCO2(3), ETNK1(4), ETNK2(1), GNPAT(4), GPAM(5), GPD1(6), GPD1L(3), GPD2(9), LCAT(3), LYPLA1(2), LYPLA2(2), NAT6(1), PCYT1A(1), PCYT1B(2), PEMT(1), PISD(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLD1(9), PLD2(3), PNPLA3(4), PPAP2A(5), PPAP2B(3), PPAP2C(1), PTDSS1(7), PTDSS2(1), SH3GLB1(1)	37665706	243	146	242	91	116	15	50	24	38	0	0.916	1.000	1.000
181	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(3), AGTR2(4), ATP8A1(11), AVPR1A(4), AVPR1B(3), AVPR2(3), BDKRB1(4), BDKRB2(2), BRS3(4), C3AR1(4), CCKAR(3), CCKBR(8), CCR1(1), CCR10(3), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(4), CX3CR1(4), CXCR3(3), CXCR4(4), CXCR6(4), EDNRA(4), EDNRB(8), FPR1(3), FSHR(5), GALR1(3), GALR2(4), GALR3(3), GALT(1), GHSR(6), GNB2L1(3), GNRHR(2), GRPR(1), LHCGR(7), MC1R(2), MC3R(4), MC4R(3), MC5R(3), NMBR(6), NPY1R(7), NPY2R(4), NPY5R(5), NTSR1(2), NTSR2(2), OPRD1(5), OPRK1(4), OPRL1(2), OXTR(1), SSTR1(3), SSTR3(4), SSTR4(6), TAC4(1), TACR1(3), TACR2(1), TACR3(5), TRHR(9), TSHR(8)	30531920	233	146	232	129	96	6	69	35	27	0	0.986	1.000	1.000
182	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(4), CASP2(2), CASP3(3), CASP8(14), CRADD(1), DFFA(6), FADD(7), JUN(4), LMNA(5), LMNB1(4), LMNB2(7), MADD(11), MAP2K4(4), MAP3K1(10), MAP3K7(8), MAPK8(5), PAK1(4), PAK2(9), PRKDC(35), RIPK1(7), SPTAN1(68), TNF(4), TNFRSF1A(5), TRADD(2), TRAF2(5)	21365070	235	146	230	60	128	10	26	12	59	0	0.314	1.000	1.000
183	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ACAT1(5), ACAT2(1), ACMSD(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), AOC2(5), AOC3(6), AOX1(8), ASMT(1), CAT(9), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(3), CYP2D6(5), CYP2E1(4), CYP2F1(4), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(9), CYP4B1(5), CYP51A1(4), DDC(8), ECHS1(1), EHHADH(6), GCDH(5), HAAO(1), HADHA(4), KMO(1), KYNU(1), MAOA(4), MAOB(2), SDS(2), TDO2(3), TPH1(3), WARS(5), WARS2(2)	32067281	224	146	221	84	110	10	46	25	33	0	0.731	1.000	1.000
184	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(3), AKT2(4), AKT3(6), BCR(3), BTK(5), CD19(4), DAPP1(2), FLOT1(3), FLOT2(5), GAB1(6), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), NR0B2(2), PDK1(2), PHF11(5), PITX2(5), PLCG2(6), PPP1R13B(7), PREX1(14), PTPRC(19), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KB1(4), SAG(2), SYK(8), TEC(10), VAV1(8)	29871189	224	145	222	82	122	8	42	21	30	1	0.818	1.000	1.000
185	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(3), ATF2(1), CDC42(4), DLD(7), DUSP10(4), DUSP4(2), DUSP8(6), GAB1(6), GADD45A(1), GCK(1), IL1R1(1), JUN(4), MAP2K4(4), MAP2K5(4), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K11(1), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K7(8), MAP3K9(11), MAPK10(9), MAPK7(3), MAPK8(5), MAPK9(5), MYEF2(5), NFATC3(10), NR2C2(6), PAPPA(15), SHC1(8), TRAF6(1), ZAK(10)	28734874	228	144	225	76	113	11	56	19	29	0	0.910	1.000	1.000
186	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(7), ACSS2(2), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH3B1(4), ALDH3B2(5), ALDH7A1(1), ALDH9A1(7), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), G6PC2(2), GALM(2), GAPDH(3), GAPDHS(2), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(1), PFKL(1), PFKM(5), PFKP(4), PGAM1(1), PGAM2(4), PGAM4(4), PGK1(2), PGM1(3), PGM3(1), PKLR(8), TPI1(1)	33826358	212	143	210	96	98	11	49	21	33	0	0.982	1.000	1.000
187	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(3), AKT2(4), AKT3(6), BRAF(9), CAB39(3), DDIT4(2), EIF4B(4), EIF4EBP1(1), FIGF(2), HIF1A(6), IGF1(2), MAPK3(8), PDPK1(2), PGF(2), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(6), PIK3R2(4), PIK3R3(5), PIK3R5(3), PRKAA1(9), PRKAA2(7), RHEB(4), RICTOR(19), RPS6(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KA6(11), RPS6KB1(4), RPS6KB2(1), TSC2(11), ULK1(9), ULK2(9), ULK3(1), VEGFA(4), VEGFB(3), VEGFC(6)	27958342	226	143	225	74	117	11	43	24	30	1	0.782	1.000	1.000
188	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	CHUK(7), DAXX(9), EGF(17), EGFR(7), ETS1(5), ETS2(5), FOS(4), HOXA7(5), IKBKB(11), JUN(4), MAP2K1(3), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK13(3), MAPK14(2), MAPK3(8), MAPK8(5), NFKB1(3), NFKBIA(6), PPP2CA(2), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(6), PRKCH(7), PRKCQ(10), RAF1(4), RELA(6), RIPK1(7), SP1(10), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRAF2(5)	28267922	230	142	227	94	118	14	46	16	36	0	0.979	1.000	1.000
189	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(3), AKT1(3), APC(29), ASAH1(4), CAMP(1), CAV3(1), DAG1(3), DLG4(4), EPHB2(10), GNAI1(4), GNAQ(3), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), PITX2(5), PTX3(6), RAC1(4), RHO(3), RYR1(54)	26624248	209	142	205	77	110	9	39	18	33	0	0.722	1.000	1.000
190	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(8), CD28(3), CSK(7), CTLA4(1), DAG1(3), EPHB2(10), GRAP2(3), GRB2(1), ITK(6), ITPKA(4), ITPKB(5), LAT(1), LCK(2), LCP2(5), NCK1(2), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PLCG1(12), PTPRC(19), RAF1(4), RASGRP1(6), RASGRP2(4), RASGRP3(5), RASGRP4(1), SOS1(23), SOS2(8), VAV1(8), ZAP70(2)	31335612	226	141	224	77	117	7	47	28	27	0	0.853	1.000	1.000
191	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(65), BMPR1B(4), CCND2(1), CDK4(5), CDKN1B(6), CEBPB(3), DAZL(3), DMC1(2), EGR1(7), ESR2(3), FSHR(5), GJA4(2), INHA(3), LHCGR(7), MLH1(9), MSH5(5), NCOR1(41), NR5A1(1), NRIP1(7), PGR(8), PRLR(4), PTGER2(7), SMPD1(4), VDR(2), ZP2(8)	20364106	212	140	209	58	88	8	42	26	47	1	0.499	1.000	1.000
192	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM1(2), CALM2(2), CD3E(2), CD3G(2), ELK1(1), FOS(4), FYN(7), GRB2(1), JUN(4), LAT(1), LCK(2), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NFKB1(3), NFKBIA(6), PIK3R1(6), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKCA(3), PTPN7(1), RAC1(4), RAF1(4), RASA1(8), RELA(6), SHC1(8), SOS1(23), SYT1(6), VAV1(8), ZAP70(2)	26292797	216	139	213	74	108	12	46	20	30	0	0.900	1.000	1.000
193	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(7), BAD(2), BAX(1), BCL2A1(1), BCL2L1(4), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CD40(3), CD40LG(2), CRADD(1), CYCS(1), DAXX(9), DFFA(6), FADD(7), FAS(1), FASLG(1), IKBKE(6), LTA(1), MCL1(2), NFKB1(3), NFKBIA(6), NGFR(4), NR3C1(6), NTRK1(6), PTPN13(19), RIPK1(7), TFG(11), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5), TRAF3(2), TRAF6(1)	25113586	188	138	183	68	107	6	34	11	30	0	0.947	1.000	1.000
194	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	45	ACOX1(6), APOA1(2), APOA2(4), CD36(2), CITED2(3), CPT1B(4), DUSP1(3), DUT(2), EHHADH(6), FABP1(2), HSD17B4(5), HSPA1A(3), JUN(4), LPL(4), MAPK3(8), ME1(5), MRPL11(2), MYC(2), NCOA1(24), NCOR1(41), NCOR2(19), NFKBIA(6), NR0B2(2), NR1H3(3), NR2F1(3), NRIP1(7), PIK3R1(6), PPARA(1), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PTGS2(6), RELA(6), SP1(10), STAT5A(1), STAT5B(5), TNF(4)	28209830	234	138	231	75	117	9	41	21	46	0	0.702	1.000	1.000
195	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(5), CALM1(2), CALM2(2), ELK1(1), FCER1A(5), FCER1G(1), FOS(4), GRB2(1), JUN(4), LYN(5), MAP2K1(3), MAP2K4(4), MAP2K7(3), MAP3K1(10), MAPK3(8), MAPK8(5), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), PAK2(9), PIK3R1(6), PLA2G4A(1), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), RAF1(4), SHC1(8), SOS1(23), SYK(8), SYT1(6), VAV1(8)	23526106	206	137	203	61	99	12	41	25	29	0	0.627	1.000	1.000
196	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	19	ATM(65), ATR(32), BRCA1(23), CCNB1(5), CDC25A(5), CDC25B(2), CDC25C(2), CDC34(1), CDKN2D(1), CHEK1(3), CHEK2(11), GADD45A(1), MDM2(6), MYT1(10), PRKDC(35), RPS6KA1(5), WEE1(10), YWHAH(2), YWHAQ(3)	20789837	222	137	217	44	105	14	36	25	40	2	0.0887	1.000	1.000
197	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(6), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPS(5), CDIPT(2), CDS1(5), CDS2(3), CHAT(4), CHKA(5), CHKB(4), CLC(2), CPT1B(4), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), ETNK1(4), GNPAT(4), GPD1(6), GPD2(9), LCAT(3), LGALS13(3), LYPLA1(2), LYPLA2(2), PAFAH1B1(2), PAFAH2(4), PCYT1A(1), PCYT1B(2), PEMT(1), PISD(3), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB2(6), PLCG1(12), PLCG2(6), PPAP2A(5), PPAP2B(3), PPAP2C(1)	28674293	224	137	223	80	107	10	47	20	40	0	0.623	1.000	1.000
198	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(15), CANT1(1), CDA(1), CTPS2(3), DCK(4), DCTD(2), DHODH(2), DPYD(14), DPYS(13), DUT(2), ENTPD1(1), ITPA(1), NME1(1), NME2(1), NT5C(1), NT5E(6), POLD1(8), POLD2(3), POLE(27), POLG(8), POLQ(28), POLR1B(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5), RRM1(4), RRM2(3), TK1(2), TXNRD1(6), TYMS(3), UCK1(2), UMPS(4), UNG(1), UPB1(4)	33291369	217	137	217	98	109	12	34	30	31	1	0.998	1.000	1.000
199	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(3), APC(29), AR(5), ASAH1(4), BRAF(9), CAMP(1), CCL13(2), CCL15(1), CCL16(1), DAG1(3), EGFR(7), GNA11(3), GNA15(5), GNAI1(4), GNAQ(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), MAPK10(9), MAPK14(2), PHKA2(8), PIK3CD(7), PIK3R1(6), PITX2(5), PTX3(6), RAF1(4), SRC(5)	29680445	213	137	210	85	111	8	37	26	31	0	0.959	1.000	1.000
200	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AKR1A1(2), AKR1B1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), CEL(8), DGAT1(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), GK(2), GLA(3), GLB1(5), LCT(16), LIPC(6), LIPF(6), LIPG(4), LPL(4), PNLIP(5), PNLIPRP1(8), PPAP2A(5), PPAP2B(3), PPAP2C(1)	27691993	224	136	221	76	108	9	47	23	37	0	0.500	1.000	1.000
201	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(12), AR(5), ESR1(5), ESR2(3), ESRRA(2), HNF4A(5), NPM1(1), NR0B1(4), NR1D1(3), NR1D2(10), NR1H2(6), NR1H3(3), NR1I2(5), NR1I3(4), NR2C2(6), NR2E1(1), NR2F1(3), NR2F2(5), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(4), NR5A1(1), NR5A2(6), PGR(8), PPARA(1), PPARD(6), PPARG(13), RARA(4), RARB(7), RARG(21), ROR1(6), RORA(4), RORC(6), RXRB(3), RXRG(8), THRA(2), THRB(1), VDR(2)	23674169	195	136	189	74	100	10	42	18	25	0	0.843	1.000	1.000
202	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(11), ACTG2(2), ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), CDC42(4), CFL1(1), CFL2(4), FLNA(14), FLNC(18), FSCN1(5), FSCN2(3), FSCN3(3), GDI1(3), GDI2(5), LIMK1(6), MYH2(22), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(10), PAK4(1), PAK6(3), PAK7(6), PFN1(4), PFN2(1), RHO(3), ROCK1(8), ROCK2(15), RPS4X(4), VASP(1), WASF1(5), WASL(2)	27858435	210	136	208	70	96	8	53	25	28	0	0.593	1.000	1.000
203	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(9), CDC7(4), CDK2(1), CDT1(2), GMNN(1), MCM10(15), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), NACA(14), PCNA(4), POLA2(11), POLD1(8), POLD2(3), POLD3(5), POLE(27), POLE2(4), RFC1(9), RFC2(5), RFC3(1), RFC4(10), RFC5(5), RPA2(1), RPA3(4), RPA4(1), RPS27A(1), UBA52(7), UBC(9)	28334208	197	135	191	61	117	9	30	17	24	0	0.541	1.000	1.000
204	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(1), PFKM(5), PFKP(4), PGAM1(1), PGK1(2), PGM1(3), PGM3(1), PKLR(8), TPI1(1)	28427706	194	135	191	78	88	9	47	19	31	0	0.900	1.000	1.000
205	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(1), PFKM(5), PFKP(4), PGAM1(1), PGK1(2), PGM1(3), PGM3(1), PKLR(8), TPI1(1)	28427706	194	135	191	78	88	9	47	19	31	0	0.900	1.000	1.000
206	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(27), ACACB(20), ACAT1(5), ACAT2(1), ACOT12(6), ACSS1(7), ACSS2(2), AKR1B1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), DLAT(6), DLD(7), GLO1(2), GRHPR(2), HAGH(2), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), LDHD(3), MDH1(3), ME1(5), ME2(1), ME3(6), PC(10), PCK1(9), PCK2(2), PDHA1(5), PDHA2(6), PDHB(1), PKLR(8)	27167995	180	134	177	67	94	6	38	18	24	0	0.825	1.000	1.000
207	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	21	COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), F10(5), F11(10), F12(3), F2(3), F2R(2), F5(24), F8(22), F9(3), FGA(17), FGB(5), FGG(7), KLKB1(2), PROC(2), SERPINC1(7), SERPING1(3)	24844183	180	134	177	62	95	10	41	16	18	0	0.987	1.000	1.000
208	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(8), BTK(5), CALM1(2), CALM2(2), CD79A(4), CD79B(2), ELK1(1), FOS(4), GRB2(1), JUN(4), LYN(5), MAP2K1(3), MAP3K1(10), MAPK14(2), MAPK3(8), MAPK8(5), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKCA(3), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SYK(8), SYT1(6), VAV1(8)	22005177	200	131	197	61	96	11	40	24	29	0	0.672	1.000	1.000
209	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	48	ACTA1(4), AGT(3), AKT1(3), CALM1(2), CALM2(2), CALR(4), CAMK1(5), CAMK1G(4), CAMK4(4), CSNK1A1(6), EDN1(2), ELSPBP1(3), F2(3), FKBP1A(1), GATA4(1), GSK3B(4), HAND1(4), HAND2(2), IGF1(2), LIF(2), MAP2K1(3), MAPK14(2), MAPK3(8), MAPK8(5), MEF2C(5), MYH2(22), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NKX2-5(5), NPPA(2), PIK3R1(6), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RAF1(4), RPS6KB1(4), SYT1(6)	25243464	211	131	210	69	93	17	48	23	29	1	0.721	1.000	1.000
210	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(9), ATM(65), BRCA1(23), CHEK1(3), CHEK2(11), GADD45A(1), JUN(4), MAPK8(5), MDM2(6), MRE11A(7), NFKB1(3), NFKBIA(6), RAD50(13), RAD51(7), RBBP8(10), RELA(6), TP73(6)	16711634	185	130	178	32	98	7	26	18	35	1	0.0776	1.000	1.000
211	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(5), ALG10B(6), ALG11(5), ALG12(3), ALG13(4), ALG14(1), ALG2(2), ALG3(1), ALG5(3), ALG6(3), ALG8(2), ALG9(2), B4GALT1(4), B4GALT2(1), B4GALT3(5), DDOST(1), DHDDS(7), DOLPP1(1), DPAGT1(6), DPM1(3), FUT8(7), GANAB(16), MAN1A1(3), MAN1A2(6), MAN1B1(9), MAN1C1(6), MAN2A1(13), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(4), MGAT5(7), MGAT5B(7), RFT1(2), RPN1(3), RPN2(5), ST6GAL1(4), STT3B(5)	24433056	185	130	184	67	92	9	32	30	22	0	0.766	1.000	1.000
212	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(3), AKT2(4), AKT3(6), BAD(2), BCR(3), BLNK(8), BTK(5), CD19(4), CSK(7), DAG1(3), EPHB2(10), GRB2(1), ITPKA(4), ITPKB(5), LYN(5), MAP2K1(3), MAP2K2(5), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PI3(1), PIK3CD(7), PIK3R1(6), PLCG2(6), PPP1R13B(7), RAF1(4), SERPINA4(2), SHC1(8), SOS1(23), SOS2(8), SYK(8), VAV1(8)	29333999	206	130	204	70	103	6	46	25	26	0	0.805	1.000	1.000
213	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(4), AKT3(6), ARHGEF11(10), CDC42(4), DLG4(4), GNA13(12), LPA(11), MAP2K4(4), MAP3K1(10), MAP3K5(14), MAPK8(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PDK1(2), PHKA2(8), PI3(1), PIK3CB(11), PLD1(9), PLD2(3), PLD3(5), PTK2(12), RDX(4), ROCK1(8), ROCK2(15), SERPINA4(2), SRF(4)	28584013	196	130	189	58	103	11	32	20	30	0	0.639	1.000	1.000
214	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(7), BID(2), BIRC2(3), BIRC3(3), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CYCS(1), DFFA(6), FADD(7), GAS2(3), LMNA(5), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), SPTAN1(68), TNFRSF10A(5), TNFRSF10B(6), TNFRSF25(3), TNFSF10(5), TRADD(2), TRAF2(5)	19334317	192	128	190	56	111	8	21	7	45	0	0.623	1.000	1.000
215	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), ELK1(1), FPR1(3), GNA15(5), GNB1(7), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAPK14(2), MAPK3(8), NCF1(1), NCF2(6), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), NFKB1(3), NFKBIA(6), PAK1(4), PIK3C2G(11), PLCB1(16), PPP3CA(7), PPP3CB(6), PPP3CC(4), RAC1(4), RAF1(4), RELA(6), SYT1(6)	21890667	189	128	188	62	92	14	37	20	26	0	0.808	1.000	1.000
216	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(4), CARS(4), CARS2(7), DARS(3), DARS2(10), EARS2(2), EPRS(12), FARS2(1), FARSA(2), FARSB(6), GARS(6), HARS(6), HARS2(1), IARS(6), IARS2(10), KARS(10), LARS(11), LARS2(3), MARS(1), MARS2(5), MTFMT(2), NARS(3), NARS2(7), PARS2(4), QARS(5), RARS(6), RARS2(6), SARS(5), SARS2(5), TARS(9), TARS2(13), VARS(5), VARS2(12), WARS(5), WARS2(2), YARS(5), YARS2(8)	31619530	216	128	213	56	122	15	33	14	32	0	0.152	1.000	1.000
217	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	59	A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(3), B3GALT4(6), B3GALT5(3), B3GNT1(3), B3GNT2(5), B3GNT3(1), B3GNT4(3), B3GNT5(8), B4GALNT1(2), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), B4GALT6(2), FUT1(3), FUT2(6), FUT3(3), FUT4(3), FUT5(5), FUT6(2), FUT7(3), FUT9(3), GCNT2(2), PIGA(3), PIGB(5), PIGC(4), PIGF(2), PIGG(7), PIGK(4), PIGL(2), PIGM(2), PIGN(1), PIGO(11), PIGQ(5), PIGT(2), PIGU(5), PIGV(5), PIGZ(3), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1), ST3GAL5(5), ST3GAL6(6), ST6GALNAC3(5), ST6GALNAC4(2), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(2), UGCG(3)	27411514	182	128	180	81	87	3	45	25	22	0	0.900	1.000	1.000
218	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(3), CALR(4), CANX(6), CD4(3), CD74(2), CD8A(2), CIITA(8), CTSB(6), CTSS(1), HLA-A(7), HLA-B(4), HLA-C(4), HLA-DMB(4), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(6), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(5), HLA-F(5), HLA-G(3), HSP90AA1(26), HSP90AB1(11), HSPA5(11), IFI30(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), KIR2DL3(2), KIR3DL1(7), KIR3DL2(1), KLRC2(2), KLRC3(4), KLRC4(3), KLRD1(1), LGMN(1), LTA(1), NFYA(2), NFYB(1), NFYC(1), PDIA3(6), PSME1(2), RFX5(6), RFXANK(1), RFXAP(2), TAP1(3), TAP2(1), TAPBP(2)	26881897	203	128	195	71	99	10	37	19	38	0	0.660	1.000	1.000
219	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(4), CRK(4), CRKL(1), DOCK1(11), ELK1(1), FOS(4), GAB1(6), GRB2(1), HGF(12), ITGA1(7), ITGB1(3), JUN(4), MAP2K1(3), MAP2K2(5), MAP4K1(8), MAPK3(8), MAPK8(5), MET(19), PAK1(4), PIK3R1(6), PTK2(12), PTK2B(6), PTPN11(4), PXN(3), RAF1(4), RAP1A(1), RAP1B(2), RASA1(8), SOS1(23), SRC(5), STAT3(6)	23512549	190	128	185	48	99	9	35	21	26	0	0.289	1.000	1.000
220	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(18), ATP4B(2), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ATP7A(7), ATP7B(9), COX10(4), COX5A(5), COX6A1(5), COX6C(2), COX7A1(1), COX7A2(1), COX7B(1), COX8A(1), NDUFA1(1), NDUFA10(4), NDUFA5(1), NDUFA8(4), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFS1(5), NDUFS2(3), NDUFV1(4), NDUFV2(6), PPA2(2), SDHA(9), SDHB(2), SHMT1(3), UQCRB(1), UQCRC1(2), UQCRFS1(3), UQCRH(2)	22214490	190	126	184	52	102	8	37	19	24	0	0.169	1.000	1.000
221	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(3), AKT2(4), AKT3(6), ANKRD6(4), APC(29), AXIN1(4), AXIN2(19), CER1(4), CSNK1A1(6), DACT1(6), DKK1(2), DKK2(5), DKK3(5), DKK4(2), DVL1(5), FSTL1(4), GSK3A(2), GSK3B(4), LRP1(36), MVP(11), NKD1(3), NKD2(1), PSEN1(8), PTPRA(2), SENP2(1), SFRP1(2), WIF1(6)	22386363	184	126	182	48	93	6	39	14	31	1	0.192	1.000	1.000
222	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(3), AGTR2(4), CALM1(2), CALM2(2), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CDK5(3), F2(3), FYN(7), GNA11(3), GNAI1(4), GNB1(7), GRB2(1), JAK2(8), MAP2K1(3), MAP2K2(5), MAPK14(2), MAPK3(8), MAPK8(5), MAPT(10), MYLK(15), PLCG1(12), PRKCA(3), PTK2B(6), RAF1(4), SHC1(8), SOS1(23), STAT1(13), STAT3(6), STAT5A(1), SYT1(6)	23969708	196	125	193	85	101	10	35	23	27	0	0.993	1.000	1.000
223	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F11(10), F12(3), F13B(9), F2(3), F5(24), F7(8), F8(22), F9(3), FGA(17), FGB(5), FGG(7), LPA(11), PLAT(6), PLG(4), SERPINB2(3), SERPINE1(6), VWF(21)	20485546	167	125	164	49	83	8	39	20	17	0	0.511	1.000	1.000
224	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(4), ACAA2(2), ACADL(2), ACADM(1), ACADS(6), ACADSB(3), ACADVL(2), ACAT1(5), ACAT2(1), ACOX1(6), ACOX3(7), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(5), ACSL6(1), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), CYP4A11(5), CYP4A22(7), ECHS1(1), EHHADH(6), GCDH(5), HADH(5), HADHA(4), HADHB(4), HSD17B10(1), HSD17B4(5)	28516176	169	125	167	63	89	7	30	12	31	0	0.805	1.000	1.000
225	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(8), POLA2(11), POLD1(8), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLG(8), POLG2(6), POLH(10), POLI(5), POLK(12), POLM(8), POLQ(28), PRIM2(1), REV1(8), REV3L(30), RFC5(5)	23539553	190	125	189	42	97	12	30	21	30	0	0.185	1.000	1.000
226	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(17), ANAPC2(12), ANAPC4(8), ANAPC5(12), ANAPC7(6), BTRC(4), CDC16(4), CDC20(4), CDC23(1), CDC27(12), CUL1(19), CUL2(13), CUL3(9), FBXW11(1), FZR1(5), ITCH(12), RBX1(1), SKP1(6), SKP2(5), SMURF1(8), SMURF2(8), TCEB1(1), UBA1(1), UBE2C(3), UBE2D1(2), UBE2D2(1), UBE2D3(3), UBE2D4(1), UBE2E2(1), UBE2E3(1), VHL(2), WWP1(5), WWP2(5)	22356601	193	125	185	40	103	7	35	17	30	1	0.119	1.000	1.000
227	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(11), EGF(17), EGFR(7), ELK1(1), FOS(4), GRB2(1), JAK1(9), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), PIK3R1(6), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4), STAT1(13), STAT3(6), STAT5A(1)	20323972	172	124	168	48	86	7	35	16	28	0	0.438	1.000	1.000
228	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(8), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH3B1(4), ALDH3B2(5), ALDH7A1(1), ALDH9A1(7), AMDHD1(4), AOC2(5), AOC3(6), ASPA(2), CARM1(6), CNDP1(4), DDC(8), FTCD(3), HAL(6), HARS(6), HARS2(1), HDC(6), HEMK1(1), HNMT(2), LCMT1(2), LCMT2(12), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), PRPS1(3), PRPS2(1), UROC1(6), WBSCR22(6)	22963508	168	124	164	49	78	7	40	17	26	0	0.170	1.000	1.000
229	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), DAG1(3), DGKA(9), GCA(1), ITGA9(9), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), MAP2K1(3), MAPK3(8), NR1I3(4), PAK1(4), PDE3A(11), PDE3B(9), PI3(1), PIK3C2G(11), PIK3CD(7), PIK3R1(6), PSME1(2), RIPK3(6), RPS4X(4), SGCB(1), VASP(1)	26912665	183	124	180	80	92	11	35	15	30	0	0.989	1.000	1.000
230	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(7), BAK1(2), BAX(1), BCL2L1(4), BID(2), BIRC2(3), BIRC3(3), CASP2(2), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), FADD(7), FAS(1), FASLG(1), GZMB(2), JUN(4), MAP2K4(4), MAP3K1(10), MAPK10(9), MCL1(2), MDM2(6), MYC(2), NFKB1(3), NFKBIA(6), PARP1(13), PRF1(7), RELA(6), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TNFSF10(5), TRADD(2), TRAF2(5)	21196701	171	122	166	55	98	8	28	13	24	0	0.715	1.000	1.000
231	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(4), AZIN1(5), BTG1(3), CBX3(1), CEBPB(3), CLDN5(3), CLOCK(8), CRY1(3), CRY2(4), DAZAP2(3), DNAJA1(4), EIF4G2(10), ETV6(12), GFRA1(4), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(10), IDI1(2), MYF6(5), NCKAP1(12), NCOA4(6), NR1D2(10), PER1(6), PER2(6), PIGF(2), PPP1R3C(4), PPP2CB(2), PSMA4(3), PURA(5), SF3A3(7), SUMO3(2), TOB1(5), TUBB3(5), UGP2(9), VAPA(6), ZFR(5)	21198935	187	122	180	59	95	11	33	18	30	0	0.885	1.000	1.000
232	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA1(4), ACAA2(2), ACADM(1), ACADS(6), ACAT1(5), ACAT2(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), AOX1(8), AUH(2), BCAT1(4), BCAT2(3), BCKDHA(4), BCKDHB(1), DBT(6), DLD(7), ECHS1(1), EHHADH(6), HADH(5), HADHA(4), HADHB(4), HMGCL(1), HMGCS1(9), HMGCS2(7), HSD17B10(1), HSD17B4(5), IVD(2), MCCC1(12), MCCC2(8), MCEE(3), MUT(9), OXCT1(4), OXCT2(2), PCCA(4), PCCB(4)	25068080	171	122	168	53	98	7	20	18	28	0	0.663	1.000	1.000
233	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), JAK1(9), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), PDGFRA(16), PIK3R1(6), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4), STAT1(13), STAT3(6), STAT5A(1)	18824159	164	122	160	46	79	6	34	16	29	0	0.417	1.000	1.000
234	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(1), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPPL1(11), ITPKA(4), ITPKB(5), OCRL(4), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3CB(11), PIK3CG(10), PLCB1(16), PLCB2(6), PLCB3(11), PLCB4(9), PLCD1(5), PLCG1(12), PLCG2(6)	24624470	177	121	175	75	90	6	37	17	27	0	0.982	1.000	1.000
235	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(3), ACTR3(2), ARHGAP1(1), ARHGAP4(3), ARHGAP5(12), ARHGAP6(8), ARHGEF1(8), ARHGEF11(10), ARHGEF5(6), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), BAIAP2(5), CFL1(1), DIAPH1(5), GSN(2), LIMK1(6), MYL2(4), MYLK(15), OPHN1(8), PFN1(4), PIP5K1A(8), PIP5K1B(3), PPP1R12B(10), ROCK1(8), SRC(5), TLN1(17), VCL(4)	26229374	173	121	171	53	86	6	38	22	21	0	0.567	1.000	1.000
236	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH4A1(4), ALDH9A1(7), AOC2(5), AOC3(6), ARG1(2), ARG2(3), ASL(6), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), GATM(3), GLUD1(6), GOT1(2), MAOA(4), MAOB(2), NOS1(15), NOS3(11), OAT(1), ODC1(4), OTC(2), P4HA1(7), P4HA3(3), P4HB(6), PYCR1(3), RARS(6), SMS(1)	25549625	169	120	164	55	92	4	30	20	22	1	0.415	1.000	1.000
237	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(1), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), FPGT(10), FUK(9), GMDS(6), GMPPA(3), GMPPB(5), HK1(15), HK2(11), HK3(8), HSD3B7(2), KHK(1), LHPP(2), MPI(7), MTMR1(8), MTMR2(6), MTMR6(8), PFKFB1(5), PFKFB2(3), PFKFB3(7), PFKL(1), PFKM(5), PFKP(4), PGM2(2), PMM1(6), PMM2(2), RDH12(2), RDH13(1), SORD(1), TPI1(1), TSTA3(2)	21450419	161	119	158	67	85	5	31	19	21	0	0.873	1.000	1.000
238	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(2), AKR1B10(1), ALAS1(12), ALAS2(3), AMT(3), AOC2(5), AOC3(6), BHMT(1), CBS(2), CHDH(5), CHKA(5), CHKB(4), CTH(5), DLD(7), DMGDH(5), GARS(6), GATM(3), GCAT(2), GLDC(8), GNMT(3), HSD3B7(2), MAOA(4), MAOB(2), PEMT(1), PHGDH(3), PIPOX(4), PISD(3), PSAT1(6), PSPH(7), RDH12(2), RDH13(1), SARDH(2), SARS(5), SARS2(5), SDS(2), SHMT1(3), SHMT2(2), TARS(9), TARS2(13)	24615860	166	119	163	69	82	9	31	14	30	0	0.921	1.000	1.000
239	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2A1(3), GTF2A1L(5), GTF2A2(1), GTF2B(2), GTF2E1(7), GTF2E2(3), GTF2F1(5), GTF2F2(2), GTF2H1(4), GTF2H3(5), GTF2H4(1), GTF2IRD1(9), STON1(13), TAF1(10), TAF10(1), TAF12(2), TAF13(2), TAF1L(21), TAF2(10), TAF4(6), TAF4B(6), TAF5(4), TAF5L(3), TAF6(6), TAF6L(6), TAF7(3), TAF7L(6), TAF9(7), TAF9B(2), TBPL1(2)	20290619	157	119	154	51	76	9	30	17	25	0	0.915	1.000	1.000
240	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	34	ACTA1(4), ACTN1(7), ACTN2(10), BCAR1(6), BCR(3), CAPN1(5), CAPNS2(1), CRKL(1), CSK(7), FYN(7), GRB2(1), ITGA1(7), ITGB1(3), JUN(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MAPK8(5), PPP1R12B(10), PTK2(12), PXN(3), RAF1(4), RAP1A(1), ROCK1(8), SHC1(8), SOS1(23), SRC(5), TLN1(17), VCL(4), ZYX(4)	27076478	186	119	183	63	96	9	40	19	22	0	0.784	1.000	1.000
241	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(1), CDC42(4), DAXX(9), DDIT3(1), ELK1(1), GRB2(1), HMGN1(2), HSPB1(1), HSPB2(4), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP3K5(14), MAP3K7(8), MAP3K9(11), MAPK14(2), MAPKAPK2(1), MAPKAPK5(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MKNK1(6), MYC(2), PLA2G4A(1), RAC1(4), RIPK1(7), RPS6KA5(9), SHC1(8), STAT1(13), TGFB1(2), TGFB3(1), TGFBR1(7), TRADD(2), TRAF2(5)	20973244	163	118	162	58	87	9	31	11	24	1	0.927	1.000	1.000
242	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(2), ALAS1(12), ALAS2(3), AMT(3), AOC2(5), AOC3(6), ATP6V0C(2), BHMT(1), CBS(2), CHDH(5), CHKA(5), CHKB(4), CPT1B(4), CTH(5), DLD(7), DMGDH(5), GARS(6), GATM(3), GCAT(2), GLDC(8), MAOA(4), MAOB(2), PEMT(1), PISD(3), PLCB2(6), PLCG1(12), PLCG2(6), PSPH(7), SARDH(2), SARS(5), SHMT1(3), SHMT2(2), TARS(9)	24201048	154	116	151	61	76	7	33	11	27	0	0.843	1.000	1.000
243	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(5), ALAS1(12), ALAS2(3), BLVRA(5), BLVRB(1), COX10(4), COX15(4), CP(5), CPOX(5), EARS2(2), EPRS(12), FECH(2), FTH1(8), FTMT(2), GUSB(3), HCCS(3), HMOX1(3), HMOX2(2), MMAB(2), PPOX(6), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), UROD(4), UROS(4)	24518901	169	116	167	57	82	7	24	24	32	0	0.834	1.000	1.000
244	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	ACVR1(7), APC(29), ATF2(1), AXIN1(4), BMP10(3), BMP2(1), BMP4(1), BMP5(6), BMP7(4), BMPR1A(3), BMPR2(9), CHRD(7), DVL1(5), FZD1(4), GATA4(1), GSK3B(4), MAP3K7(8), MEF2C(5), MYL2(4), NKX2-5(5), NOG(2), NPPA(2), NPPB(1), RFC1(9), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8), TGFBR3(10)	20197898	153	115	150	48	79	7	24	11	31	1	0.810	1.000	1.000
245	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	23	BRCA1(23), CARM1(6), CCND1(4), ERCC3(7), ESR1(5), GRIP1(12), GTF2A1(3), GTF2E1(7), GTF2F1(5), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(6), HDAC6(12), MEF2C(5), NCOR2(19), NR0B1(4), NRIP1(7), PELP1(5), POLR2A(13), TBP(2)	20802962	155	115	151	56	86	6	31	14	18	0	0.843	1.000	1.000
246	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	21	ABL1(9), ATM(65), ATR(32), CCNA1(4), CCND1(4), CCNE1(3), CDC25A(5), CDK2(1), CDK4(5), CDK6(5), CDKN1B(6), CDKN2B(2), E2F1(3), GSK3B(4), HDAC1(4), SKP2(5), TFDP1(2), TGFB1(2), TGFB3(1)	15540450	162	115	156	34	78	8	25	20	29	2	0.100	1.000	1.000
247	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(11), ACTG2(2), ADCY3(5), ADCY9(8), AK1(1), ARF3(1), ARF4(1), ARF5(2), ARF6(1), ARL4D(1), ATP6V0A1(12), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ERO1L(4), GNAS(12), PDIA4(5), PLCG1(12), PLCG2(6), PRKCA(3), SEC61A1(5), SEC61A2(7), TRIM23(5)	21561162	161	115	161	58	83	11	29	18	20	0	0.667	1.000	1.000
248	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(27), ACAT1(5), ACAT2(1), ADH5(1), AKR1B1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), DLAT(6), DLD(7), GLO1(2), GRHPR(2), HAGH(2), LDHB(2), LDHC(4), LDHD(3), MDH1(3), ME1(5), ME2(1), ME3(6), PC(10), PCK1(9), PDHA1(5), PDHA2(6), PDHB(1), PKLR(8)	21467689	151	115	148	54	81	3	32	14	21	0	0.791	1.000	1.000
249	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(2), CDK5(3), CDK5R1(5), CFL1(1), CHN1(3), LIMK1(6), MAP3K1(10), MYL2(4), MYLK(15), NCF2(6), PAK1(4), PDGFRA(16), PIK3R1(6), PLD1(9), PPP1R12B(10), RAC1(4), RALBP1(2), RPS6KB1(4), TRIO(36), VAV1(8), WASF1(5)	19054746	159	115	158	59	78	6	30	14	30	1	0.945	1.000	1.000
250	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(3), AKT2(4), AKT3(6), BAD(2), GRB2(1), GSK3A(2), GSK3B(4), IL4R(6), IRS1(9), IRS2(5), JAK1(9), JAK3(12), MAP4K1(8), MAPK3(8), PDK1(2), PIK3CD(7), PIK3R1(6), PPP1R13B(7), RAF1(4), SHC1(8), SOS1(23), SOS2(8), STAT6(9)	19964236	153	115	152	54	72	4	33	20	24	0	0.870	1.000	1.000
251	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(5), ALDOB(3), ALDOC(2), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GAPDHS(2), GCK(1), GOT1(2), GPI(4), HK1(15), HK2(11), HK3(8), LDHAL6B(2), LDHB(2), LDHC(4), MDH1(3), PC(10), PCK1(9), PDHA1(5), PDHA2(6), PDHB(1), PDHX(4), PFKL(1), PFKM(5), PFKP(4), PGAM1(1), PGAM2(4), PGK1(2), PKLR(8), TNFAIP1(2), TPI1(1)	24702421	159	114	157	74	78	5	42	15	19	0	0.971	1.000	1.000
252	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(5), AKT1(3), AKT2(4), AKT3(6), DAG1(3), GNAQ(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PDK1(2), PHKA2(8), PIK3CB(11), PITX2(5), PLD1(9), PLD2(3), PLD3(5), VN1R1(1)	26038876	165	113	161	69	91	7	31	12	24	0	0.941	1.000	1.000
253	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(7), ELK1(1), GNAS(12), GNB1(7), GRB2(1), IGF1R(11), ITGB1(3), KLK2(1), MAP2K1(3), MAP2K2(5), MAPK3(8), MKNK1(6), MKNK2(3), MYC(2), NGFR(4), PDGFRA(16), PPP2CA(2), PTPRR(7), RAF1(4), RPS6KA1(5), RPS6KA5(9), SHC1(8), SOS1(23), SRC(5), STAT3(6)	19021277	159	112	157	56	80	7	37	21	14	0	0.837	1.000	1.000
254	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(4), ARSD(7), ARSE(2), ASAH1(4), B4GALT6(2), CERK(2), DEGS1(3), ENPP7(4), GAL3ST1(5), GALC(4), GBA(4), GLA(3), GLB1(5), LCT(16), NEU1(2), NEU2(3), NEU3(7), NEU4(5), PPAP2A(5), PPAP2B(3), PPAP2C(1), SGMS1(3), SGMS2(4), SGPP1(3), SGPP2(2), SMPD1(4), SMPD2(2), SMPD3(5), SMPD4(9), SPHK1(1), SPHK2(10), SPTLC1(4), SPTLC2(5), UGCG(3), UGT8(6)	20576642	152	112	152	53	66	5	45	18	18	0	0.520	1.000	1.000
255	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(4), AASDH(13), AASS(11), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), ATP6V0C(2), BBOX1(4), DLST(1), DOT1L(21), ECHS1(1), EHHADH(6), EHMT1(8), EHMT2(12), GCDH(5), HADHA(4), PLOD1(3), PLOD2(5), PLOD3(5), SDS(2), SHMT1(3), SHMT2(2), TMLHE(2)	21430958	153	112	152	74	82	7	30	14	20	0	0.998	1.000	1.000
256	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(3), APAF1(7), ATM(65), BAD(2), BAX(1), BCL2L1(4), BID(2), CASP3(3), CASP6(1), CASP7(5), CASP9(6), CYCS(1), EIF2S1(5), PRKCA(3), PTK2(12), PXN(3), STAT1(13), TLN1(17)	15471139	153	111	148	34	72	10	24	15	31	1	0.173	1.000	1.000
257	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(2), ABAT(4), ACADS(6), ACAT1(5), ACAT2(1), ACSM1(2), AKR1B10(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), BDH2(3), DDHD1(11), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADH(5), HADHA(4), HMGCL(1), HMGCS1(9), HMGCS2(7), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(3), L2HGDH(4), OXCT1(4), OXCT2(2), PDHA1(5), PDHA2(6), PDHB(1), PLA1A(3), PPME1(2), PRDX6(5), RDH12(2), RDH13(1)	23540402	152	111	151	62	82	10	24	18	18	0	0.941	1.000	1.000
258	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX12(2), ALOX12B(2), ALOX15(5), ALOX15B(3), ALOX5(4), CBR1(2), CBR3(1), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(3), CYP2E1(4), CYP2J2(2), CYP2U1(2), CYP4A11(5), CYP4A22(7), CYP4F2(7), CYP4F3(3), DHRS4(2), EPHX2(4), GGT1(5), GPX2(1), GPX3(1), GPX5(2), GPX6(3), GPX7(4), LTA4H(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PTGDS(1), PTGES2(2), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3)	22520009	144	110	144	68	61	9	38	14	22	0	0.932	1.000	1.000
259	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(4), AKT1(3), AKT2(4), AKT3(6), BAD(2), BTK(5), DAPP1(2), GRB2(1), GSK3A(2), GSK3B(4), IARS(6), IGFBP1(4), INPP5D(5), PDK1(2), PPP1R13B(7), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(8), SOS1(23), SOS2(8), TEC(10), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6)	18836204	154	110	153	42	87	7	22	16	20	2	0.503	1.000	1.000
260	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(3), AGTR1(3), ATF2(1), CALM1(2), CALM2(2), EGFR(7), ELK1(1), GNAQ(3), GRB2(1), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), PAK1(4), PRKCA(3), PTK2(12), PTK2B(6), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SRC(5), SYT1(6)	19173629	155	109	152	50	73	11	28	20	23	0	0.771	1.000	1.000
261	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(6), CALM1(2), CALM2(2), ELK1(1), FOS(4), GNAI1(4), GNAQ(3), GNAS(12), GNB1(7), JUN(4), MAP2K1(3), MAPK3(8), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), RAF1(4), RPS6KA3(8), SYT1(6)	20057495	167	109	164	50	73	14	38	19	23	0	0.536	1.000	1.000
262	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(1), BCR(3), BLNK(8), ELK1(1), FOS(4), GRB2(1), JUN(4), LYN(5), MAP2K1(3), MAP3K1(10), MAPK3(8), MAPK8IP3(11), PAPPA(15), RAC1(4), RPS6KA1(5), RPS6KA3(8), SHC1(8), SOS1(23), SYK(8), VAV1(8), VAV2(8), VAV3(7)	18263479	153	109	150	51	79	3	34	20	17	0	0.751	1.000	1.000
263	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(9), EIF1(1), EIF2B1(1), EIF2B2(5), EIF2B3(1), EIF2B4(10), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), ELAVL1(7), FLT1(8), FLT4(10), HIF1A(6), KDR(19), NOS3(11), PIK3R1(6), PLCG1(12), PRKCA(3), PTK2(12), PXN(3), SHC1(8), VHL(2)	18214004	157	109	156	50	80	8	26	14	29	0	0.623	1.000	1.000
264	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(3), CABIN1(10), CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), HDAC5(6), IGF1(2), IGF1R(11), INSR(10), MAP2K6(1), MAPK14(2), MAPK7(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MYOD1(1), NFATC1(13), NFATC2(13), PIK3R1(6), PPP3CA(7), PPP3CB(6), PPP3CC(4), SYT1(6), YWHAH(2)	18811109	137	108	137	54	61	11	30	12	23	0	0.895	1.000	1.000
265	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(2), ACP5(8), ACPP(11), ACPT(4), ALPI(5), ALPL(4), ALPP(3), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(3), CYP2D6(5), CYP2E1(4), CYP2F1(4), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(9), CYP4B1(5), CYP51A1(4), PON1(6)	17021974	148	106	143	63	73	10	35	12	18	0	0.749	1.000	1.000
266	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ALDH4A1(4), CAD(15), CPS1(13), EARS2(2), EPRS(12), GAD1(8), GAD2(6), GCLC(6), GCLM(2), GFPT1(5), GFPT2(5), GLS(3), GLS2(4), GLUD1(6), GLUD2(10), GLUL(3), GMPS(5), GNPNAT1(3), GOT1(2), GPT(2), GPT2(1), GSR(2), GSS(7), NADSYN1(6), NAGK(5), PPAT(4), QARS(5)	22982504	150	106	149	59	74	11	33	14	18	0	0.906	1.000	1.000
267	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(3), BAD(2), BCL2L1(4), CBL(8), CFLAR(2), CRKL(1), E2F1(3), FOS(4), GRB2(1), IL2RA(1), IL2RB(2), IL2RG(5), IRS1(9), JAK1(9), JAK3(12), MAPK3(8), MYC(2), NMI(4), PIK3R1(6), PPIA(1), PTPN6(2), RAF1(4), RPS6KB1(4), SHC1(8), SOCS3(1), SOS1(23), STAT5A(1), STAT5B(5), SYK(8)	19441633	143	106	141	64	61	7	30	16	28	1	0.994	1.000	1.000
268	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(4), ACAA2(2), ACADL(2), ACADM(1), ACADS(6), ACADSB(3), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), AOX1(8), BCAT1(4), BCKDHA(4), BCKDHB(1), ECHS1(1), EHHADH(6), HADHA(4), HADHB(4), HMGCL(1), IVD(2), MCCC1(12), MCCC2(8), MCEE(3), MUT(9), OXCT1(4), PCCA(4), PCCB(4), SDS(2)	20998937	138	106	135	54	78	7	16	14	23	0	0.959	1.000	1.000
269	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(4), ABAT(4), ACY3(8), ADSL(4), ADSS(4), ADSSL1(4), AGXT(2), AGXT2(2), ASL(6), ASNS(1), ASPA(2), ASRGL1(3), ASS1(2), CAD(15), CRAT(10), DARS(3), DARS2(10), DDO(1), DLAT(6), DLD(7), GAD1(8), GAD2(6), GOT1(2), GPT(2), GPT2(1), NARS(3), NARS2(7), PC(10), PDHA1(5), PDHA2(6), PDHB(1)	21969274	153	105	151	58	84	9	30	12	18	0	0.868	1.000	1.000
270	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(2), ARG2(3), ASL(6), ASS1(2), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), EPRS(12), GATM(3), GLUD1(6), GLUD2(10), GOT1(2), LAP3(4), NOS1(15), NOS3(11), OAT(1), OTC(2), P4HA1(7), P4HA3(3), PARS2(4), PRODH(3), PYCR1(3), PYCR2(1), PYCRL(3), RARS(6), RARS2(6)	20764080	152	105	145	46	89	7	26	12	17	1	0.403	1.000	1.000
271	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), AKT2(4), AKT3(6), CISH(1), GRB2(1), IARS(6), IL13RA1(2), IL2RG(5), IL4R(6), INPP5D(5), JAK1(9), JAK2(8), JAK3(12), NR0B2(2), PI3(1), PPP1R13B(7), RPS6KB1(4), SERPINA4(2), SHC1(8), SOS1(23), SOS2(8), SRC(5), STAT6(9), TYK2(9)	20098028	146	105	145	50	73	4	30	17	21	1	0.803	1.000	1.000
272	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(27), ACACB(20), ACADM(1), ACAT1(5), ACAT2(1), ACSS1(7), ACSS2(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), MCEE(3), MLYCD(2), MUT(9), PCCA(4), PCCB(4), SUCLA2(2), SUCLG1(2), SUCLG2(3)	23121877	139	104	138	48	72	6	22	18	21	0	0.741	1.000	1.000
273	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BAD(2), BRAF(9), CREB5(10), DUSP4(2), DUSP6(7), DUSP9(3), EEF2K(7), EIF4E(2), GRB2(1), MAP2K1(3), MAP2K2(5), MAP3K8(5), MAPK3(8), MKNK1(6), MKNK2(3), MOS(2), NFKB1(3), RAP1A(1), RPS6KA1(5), RPS6KA2(10), RPS6KA3(8), SHC1(8), SOS1(23), SOS2(8), TRAF3(2)	17148106	145	104	143	42	74	5	25	19	22	0	0.617	1.000	1.000
274	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(11), FOS(4), GRB2(1), JAK2(8), JUN(4), MAP2K1(3), MAPK3(8), MPL(7), PIK3R1(6), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), STAT1(13), STAT3(6), STAT5A(1), STAT5B(5), THPO(4)	15978827	139	104	135	42	77	7	19	12	24	0	0.658	1.000	1.000
275	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(10), ACO1(4), ACO2(5), CLYBL(5), CS(3), DLD(7), DLST(1), FH(7), IDH1(9), IDH2(2), IDH3A(3), IDH3B(4), IDH3G(1), MDH1(3), OGDH(21), OGDHL(10), PC(10), PCK1(9), PCK2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(3), SUCLA2(2), SUCLG1(2), SUCLG2(3)	17417733	139	103	136	58	75	4	31	13	16	0	0.891	1.000	1.000
276	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(21), BAIAP2(5), CASP1(9), CASP3(3), CASP7(5), CASP8(14), GAPDH(3), INSR(10), ITCH(12), MAGI1(15), MAGI2(17), RERE(15), WWP1(5), WWP2(5)	13988690	139	103	135	36	80	3	27	13	16	0	0.265	1.000	1.000
277	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(8), COMT(3), DBH(4), DCT(8), DDC(8), FAH(3), GOT1(2), GSTZ1(2), HGD(4), HPD(4), MAOA(4), MAOB(2), TAT(5), TH(2), TPO(16), TYR(12)	18344190	140	103	140	42	59	3	40	13	25	0	0.195	1.000	1.000
278	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(5), AKR1D1(5), ARSB(8), ARSD(7), ARSE(2), CYP11B1(4), CYP11B2(13), HSD11B2(3), HSD17B2(6), HSD17B3(1), HSD17B8(4), HSD3B1(5), HSD3B2(5), SRD5A1(4), STS(5), SULT1E1(1), SULT2A1(4), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4)	15863593	124	101	124	36	59	8	29	16	12	0	0.245	1.000	1.000
279	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	BCAR1(6), CALM1(2), CALM2(2), CRKL(1), GNAQ(3), GRB2(1), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP3K1(10), MAPK14(2), MAPK3(8), MAPK8(5), PAK1(4), PLCG1(12), PRKCA(3), PTK2B(6), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SRC(5), SYT1(6)	16305512	137	101	134	48	70	7	27	15	18	0	0.861	1.000	1.000
280	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(7), ACTN2(10), CAPN1(5), CAPNS2(1), ITGA1(7), ITGB1(3), ITGB3(9), PTK2(12), PXN(3), RAC1(4), SPTAN1(68), SRC(5), TLN1(17)	16549937	155	101	154	42	77	6	24	9	39	0	0.281	1.000	1.000
281	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(12), DIAPH1(5), FYN(7), GSN(2), ITGA1(7), ITGB1(3), MAP2K1(3), MAPK3(8), MYL2(4), MYLK(15), PFN1(4), PIK3R1(6), PTK2(12), PXN(3), RAF1(4), ROCK1(8), SHC1(8), SRC(5), TLN1(17)	20235402	133	100	133	38	62	5	30	18	18	0	0.549	1.000	1.000
282	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(5), ARSB(8), FUCA1(2), FUCA2(6), GALNS(3), GBA(4), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), HGSNAT(4), HPSE(4), HPSE2(4), HYAL2(4), IDS(4), IDUA(1), LCT(16), MAN2B1(8), MAN2B2(7), MAN2C1(8), MANBA(5), NAGLU(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5), SPAM1(2)	19832019	132	100	131	44	71	3	26	19	13	0	0.455	1.000	1.000
283	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CEBPB(3), CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), IL6(4), IL6R(4), IL6ST(9), JAK1(9), JAK2(8), JAK3(12), JUN(4), MAP2K1(3), MAPK3(8), PTPN11(4), RAF1(4), SHC1(8), SOS1(23), SRF(4), STAT3(6)	13599593	130	100	127	30	70	5	21	17	17	0	0.118	1.000	1.000
284	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(2), CDC42(4), CREB5(10), DUSP1(3), DUSP10(4), EEF2K(7), EIF4E(2), ELK1(1), GADD45A(1), HSPB1(1), IL1R1(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K10(2), MAP3K4(20), MAP3K5(14), MAP3K7(8), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPKAPK2(1), MAPKAPK5(3), MKNK1(6), MKNK2(3), MYEF2(5), NFKB1(3), NR2C2(6), SRF(4), TRAF6(1)	19295118	138	100	136	43	69	7	31	13	18	0	0.646	1.000	1.000
285	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(3), CHUK(7), ELK1(1), FOS(4), IKBKB(11), IRAK1(3), JUN(4), LY96(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP3K7(8), MAPK14(2), MAPK8(5), MYD88(1), NFKB1(3), NFKBIA(6), PPARA(1), RELA(6), TLR10(12), TLR2(3), TLR3(10), TLR4(6), TLR6(6), TLR7(9), TLR9(6), TOLLIP(3), TRAF6(1)	21134052	143	100	141	54	73	8	23	11	28	0	0.930	1.000	1.000
286	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(7), CALCR(9), CALCRL(8), CD97(5), CRHR1(2), CRHR2(3), ELTD1(10), EMR1(6), EMR2(6), GHRHR(3), GIPR(3), GLP1R(3), GLP2R(2), GPR64(7), LPHN1(9), LPHN2(21), LPHN3(21), SCTR(4), VIPR1(1), VIPR2(4)	15363566	134	99	134	70	48	7	40	14	25	0	0.985	1.000	1.000
287	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(4), ACAA2(2), ACAD8(3), ACAD9(5), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1B10(1), AKR1C4(5), AKR1D1(5), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), BAAT(3), CEL(8), CYP27A1(9), CYP7A1(10), HADHB(4), HSD3B7(2), LIPA(3), RDH12(2), RDH13(1), SLC27A5(9), SOAT1(5), SOAT2(1), SRD5A1(4)	18295273	134	98	128	46	68	8	27	9	22	0	0.427	1.000	1.000
288	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(3), EIF4A1(4), EIF4A2(11), EIF4E(2), EIF4EBP1(1), EIF4G1(17), EIF4G2(10), EIF4G3(27), GHR(6), IRS1(9), MAPK14(2), MAPK3(8), MKNK1(6), PABPC1(7), PDK2(2), PDPK1(2), PIK3R1(6), PRKCA(3), RPS6KB1(4)	14684703	130	97	129	44	57	7	30	13	22	1	0.942	1.000	1.000
289	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(6), CHIA(7), CHIT1(7), CMAS(2), CTBS(2), CYB5R1(4), CYB5R3(4), GFPT1(5), GFPT2(5), GNE(8), GNPDA1(3), GNPDA2(2), GNPNAT1(3), HEXA(3), HEXB(2), HK1(15), HK2(11), HK3(8), LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), NAGK(5), NPL(2), PGM3(1), RENBP(4), UAP1(5)	16623480	138	97	137	47	75	7	25	15	16	0	0.724	1.000	1.000
290	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(8), EGF(17), EGFR(7), GRB2(1), MAP2K1(3), MAPK3(8), PTPRB(16), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SPRY1(3), SPRY2(5), SPRY3(3), SPRY4(4), SRC(5)	14284640	123	96	122	36	65	6	26	14	12	0	0.558	1.000	1.000
291	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	20	APC(29), AXIN1(4), BTRC(4), CCND1(4), CSNK1A1(6), CSNK1D(3), CSNK2A1(11), CTBP1(4), DVL1(5), FZD1(4), GSK3B(4), HDAC1(4), MAP3K7(8), MYC(2), NLK(6), PPARD(6), PPP2CA(2), TLE1(6), WIF1(6)	13320776	118	96	116	40	64	6	17	11	20	0	0.908	1.000	1.000
292	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRA2A(3), ADRA2C(3), ADRB1(3), ADRB2(3), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), HRH1(9), HRH2(1), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5)	14857312	119	95	116	67	59	5	34	11	10	0	0.847	1.000	1.000
293	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(4), CDK7(6), ERCC3(7), GTF2A2(1), GTF2B(2), GTF2E1(7), GTF2E2(3), GTF2F2(2), GTF2H1(4), GTF2H4(1), ILK(3), MNAT1(4), POLR1A(18), POLR1B(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3B(6), POLR3D(1), POLR3E(4), POLR3H(2), TAF12(2), TAF13(2), TAF5(4), TAF6(6), TAF7(3), TAF9(7), TBP(2)	20384628	141	95	139	56	84	8	17	12	20	0	0.980	1.000	1.000
294	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), IGF1(2), IGF1R(11), IRS1(9), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PIK3R1(6), PTPN11(4), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4)	12895596	116	94	113	31	59	3	22	17	15	0	0.386	1.000	1.000
295	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ACADL(2), ACADM(1), ACADSB(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), AOC2(5), AOC3(6), CNDP1(4), DPYD(14), DPYS(13), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), MLYCD(2), SDS(2), SMS(1), UPB1(4)	16930150	119	93	118	46	54	9	25	17	14	0	0.878	1.000	1.000
296	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(4), CAD(15), CPS1(13), EPRS(12), GAD1(8), GAD2(6), GCLC(6), GCLM(2), GFPT1(5), GLS(3), GLS2(4), GLUD1(6), GLUL(3), GMPS(5), GOT1(2), GPT(2), GPT2(1), GSS(7), NADSYN1(6), PPAT(4), QARS(5)	19339820	123	93	122	50	60	10	24	12	17	0	0.940	1.000	1.000
297	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(16), C5(9), C6(9), C7(4), ICAM1(7), IL1A(1), IL6(4), ITGA4(19), ITGAL(17), ITGB1(3), ITGB2(7), SELP(7), SELPLG(3), TNF(4), VCAM1(14)	14431991	124	93	124	42	66	7	25	11	15	0	0.668	1.000	1.000
298	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(27), ACADL(2), ACADM(1), ACADSB(3), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), LDHB(2), LDHC(4), MCEE(3), MLYCD(2), MUT(9), PCCA(4), PCCB(4), SDS(2), SUCLA2(2), SUCLG1(2), SUCLG2(3)	19322692	124	93	123	44	67	5	19	15	18	0	0.857	1.000	1.000
299	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCR3(3), CFL1(1), GNAQ(3), GNAS(12), GNB1(7), LIMK1(6), MAP2K1(3), MAPK3(8), MYL2(4), NOX1(4), PIK3C2G(11), PLCB1(16), PPP1R12B(10), PRKCA(3), PTK2(12), RAF1(4), ROCK2(15)	14329104	122	92	120	38	66	7	22	17	10	0	0.763	1.000	1.000
300	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(6), AKT1(3), ASAH1(4), GNAI1(4), GNB1(7), ITGAV(13), ITGB3(9), MAPK3(8), PDGFRA(16), PIK3R1(6), PLCB1(16), PRKCA(3), PTK2(12), RAC1(4), SMPD1(4), SMPD2(2), SPHK1(1), SRC(5)	14705479	123	92	122	36	55	8	29	15	16	0	0.381	1.000	1.000
301	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(3), GHR(6), GRB2(1), INSR(10), IRS1(9), JAK2(8), MAP2K1(3), MAPK3(8), PIK3R1(6), PLCG1(12), PRKCA(3), PTPN6(2), RAF1(4), RPS6KA1(5), SHC1(8), SLC2A4(4), SOS1(23), SRF(4), STAT5A(1), STAT5B(5)	17779015	125	92	124	55	66	3	25	14	17	0	0.978	1.000	1.000
302	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(1), B4GALT1(4), B4GALT2(1), G6PC(2), G6PC2(2), GAA(5), GALK1(2), GALT(1), GANC(7), GCK(1), GLA(3), GLB1(5), HK1(15), HK2(11), HK3(8), HSD3B7(2), LCT(16), MGAM(13), PFKL(1), PFKM(5), PFKP(4), PGM1(3), PGM3(1), RDH12(2), RDH13(1), UGP2(9)	22312520	127	92	124	65	65	5	24	14	19	0	0.989	1.000	1.000
303	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), INSR(10), IRS1(9), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PIK3R1(6), PTPN11(4), RAF1(4), RASA1(8), SHC1(8), SLC2A4(4), SOS1(23), SRF(4)	13265603	117	92	114	39	64	3	20	16	14	0	0.750	1.000	1.000
304	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(16), AKT1(3), ATM(65), BAX(1), CPB2(5), CSNK1A1(6), CSNK1D(3), FHL2(1), GADD45A(1), HIF1A(6), HSPA1A(3), IGFBP3(1), MAPK8(5), MDM2(6), NFKBIB(6)	11410857	128	92	124	30	56	8	20	16	27	1	0.382	1.000	1.000
305	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(2), ALOX15(5), ALOX5(4), CBR1(2), CBR3(1), CYP4F2(7), CYP4F3(3), EPX(6), GGT1(5), LPO(8), LTA4H(3), MPO(4), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), PTGDS(1), PTGES2(2), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3), TPO(16)	16145160	124	92	123	46	58	5	30	11	20	0	0.507	1.000	1.000
306	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(29), ASAH1(4), CAMP(1), CASP3(3), CERK(2), CREB5(10), CXCL2(1), DAG1(3), EPHB2(10), FOS(4), GNAQ(3), ITPKA(4), ITPKB(5), JUN(4), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5)	16506815	126	92	123	37	62	4	28	12	20	0	0.509	1.000	1.000
307	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), DAG1(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), NFAT5(15), PDE6A(4), PDE6B(5), PDE6C(5), PDE6H(1), SLC6A13(2), TF(4)	20732514	130	92	128	63	76	5	22	9	18	0	0.991	1.000	1.000
308	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(2), CHUK(7), EGR2(3), EGR3(3), GNAQ(3), MAP3K1(10), MYC(2), NFATC1(13), NFATC2(13), NFKB1(3), NFKBIA(6), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RELA(6), SYT1(6), VIPR2(4)	16257616	132	92	132	45	61	12	29	8	22	0	0.763	1.000	1.000
309	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(3), ARRB2(4), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CLCA1(8), CLCA2(5), CLCA4(12), CNGA3(4), CNGB1(13), GNAL(4), GUCA1B(1), GUCA1C(1), PDE1C(15), PRKACA(2), PRKACB(2), PRKACG(2), PRKG1(8), PRKG2(8), PRKX(1)	17727032	125	91	125	58	63	5	23	14	20	0	0.987	1.000	1.000
310	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), IL2(1), IL2RA(1), IL2RB(2), IL2RG(5), JAK1(9), JAK3(12), JUN(4), LCK(2), MAP2K1(3), MAPK3(8), MAPK8(5), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5), SYK(8)	13196748	118	91	115	42	53	5	26	17	17	0	0.746	1.000	1.000
311	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(6), AKT1(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), GNAS(12), GRB2(1), MAPK14(2), MAPK3(8), PIK3R1(6), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), RAC1(4), RPS6KA1(5), RPS6KA5(9), SOS1(23)	15423942	121	90	120	49	68	3	24	13	13	0	0.958	1.000	1.000
312	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), FPGT(10), GCK(1), GMDS(6), GMPPA(3), GMPPB(5), HK1(15), HK2(11), HK3(8), KHK(1), MPI(7), PFKFB1(5), PFKFB3(7), PFKM(5), PFKP(4), PMM1(6), PMM2(2), SORD(1), TPI1(1)	13797654	115	90	112	49	59	4	23	13	16	0	0.818	1.000	1.000
313	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	ACTA1(4), CAPN1(5), CAPN2(2), CAPNS2(1), CXCR3(3), EGF(17), EGFR(7), ITGA1(7), ITGB1(3), MAPK3(8), MYL2(4), MYLK(15), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTK2(12), PXN(3), TLN1(17)	18700675	128	90	128	46	58	10	32	11	17	0	0.789	1.000	1.000
314	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(4), ACAA2(2), ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1C4(5), AKR1D1(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), BAAT(3), CEL(8), CYP27A1(9), CYP7A1(10), HADHB(4), SOAT2(1), SRD5A1(4)	13483670	113	88	108	32	52	8	26	9	18	0	0.190	1.000	1.000
315	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	DUSP1(3), GORASP1(2), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(2), MAPK3(8), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MAPKAPK5(3), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PIK3CD(7), PIK3R1(6), SYT1(6), TRAF2(5), TRAF3(2), TRAF5(1), TRAF6(1)	18086560	124	88	123	42	62	9	28	9	16	0	0.626	1.000	1.000
316	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	17	CSF1(4), CSF1R(11), DDX20(10), E2F1(3), E2F4(2), ETS1(5), ETS2(5), ETV3(1), FOS(4), HDAC2(3), HDAC5(6), JUN(4), NCOR2(19), RBL1(9), RBL2(9), SIN3A(12), SIN3B(5)	14710093	112	87	110	35	56	1	23	13	19	0	0.517	1.000	1.000
317	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(6), GABBR1(6), GPRC5A(2), GPRC5B(1), GPRC5C(3), GPRC5D(1), GRM1(22), GRM2(10), GRM3(8), GRM4(9), GRM5(18), GRM7(12), GRM8(8)	12244303	106	87	105	48	45	6	29	12	14	0	0.737	1.000	1.000
318	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(3), DLAT(6), DLD(7), DLST(1), FH(7), IDH2(2), IDH3A(3), IDH3B(4), IDH3G(1), MDH1(3), OGDH(21), PC(10), PDHA1(5), PDHA2(6), PDHB(1), PDHX(4), PDK1(2), PDK2(2), PDK3(1), PDK4(1), PDP2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(3), SUCLA2(2), SUCLG1(2), SUCLG2(3)	16514949	120	87	116	44	64	5	29	10	12	0	0.800	1.000	1.000
319	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(4), BIRC2(3), BIRC3(3), CASP3(3), CASP8(14), CFLAR(2), FADD(7), JUN(4), MAP2K4(4), MAP3K3(3), MAP3K7(8), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NR2C2(6), RALBP1(2), RIPK1(7), TNF(4), TNFAIP3(7), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5)	15779448	124	87	119	33	77	4	17	8	18	0	0.255	1.000	1.000
320	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(4), B4GALT2(1), FBP2(2), G6PC(2), GAA(5), GALK1(2), GALT(1), GANAB(16), GCK(1), GLA(3), GLB1(5), HK1(15), HK2(11), HK3(8), LCT(16), MGAM(13), PFKM(5), PFKP(4), PGM1(3), PGM3(1)	18802492	120	86	119	56	60	4	26	12	18	0	0.954	1.000	1.000
321	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(4), ARSB(8), ARSD(7), ARSE(2), ASAH1(4), GAL3ST1(5), GALC(4), GBA(4), GLA(3), GLB1(5), LCT(16), NEU1(2), NEU2(3), NEU3(7), NEU4(5), PPAP2A(5), PPAP2B(3), PPAP2C(1), SMPD1(4), SMPD2(2), SPTLC1(4), SPTLC2(5), UGCG(3)	13934575	106	86	106	33	49	5	26	14	12	0	0.404	1.000	1.000
322	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(3), EIF4A1(4), EIF4A2(11), EIF4B(4), EIF4E(2), EIF4EBP1(1), EIF4G1(17), EIF4G2(10), EIF4G3(27), FKBP1A(1), MKNK1(6), PDK2(2), PDPK1(2), PIK3R1(6), PPP2CA(2), RPS6(5), RPS6KB1(4), TSC2(11)	12888351	118	86	117	37	51	7	28	9	22	1	0.835	1.000	1.000
323	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(6), AP2A1(6), AP2M1(2), BIN1(5), CALM1(2), CALM2(2), DNM1(11), EPN1(1), EPS15(10), NME1(1), NME2(1), PICALM(8), PPP3CA(7), PPP3CB(6), PPP3CC(4), SYNJ1(20), SYNJ2(8), SYT1(6)	12615416	106	86	106	32	58	5	12	13	18	0	0.698	1.000	1.000
324	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(3), BCR(3), CRKL(1), FOS(4), GRB2(1), JAK2(8), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), MYC(2), PIK3R1(6), RAF1(4), SOS1(23), STAT1(13), STAT5A(1), STAT5B(5)	14842617	108	85	104	41	57	4	15	10	22	0	0.945	1.000	1.000
325	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(2), DLG4(4), GRIN1(7), GRIN2A(14), GRIN2B(10), GRIN2C(10), GRIN2D(9), NOS1(15), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), SYT1(6)	14795900	119	85	116	43	46	11	29	17	15	1	0.665	1.000	1.000
326	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(5), DLG4(4), EPHB2(10), F2(3), F2RL1(5), F2RL2(2), F2RL3(2), JUN(4), MAP2K5(4), MAPK7(3), MAPK8(5), MYEF2(5), PLD1(9), PLD2(3), PLD3(5), PTK2(12), RAF1(4), RASAL1(8), SRC(5), TEC(10), VAV1(8)	15908002	116	85	114	43	56	10	20	15	15	0	0.822	1.000	1.000
327	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(7), IFNA1(1), IFNB1(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1RAP(5), IL1RN(1), IL6(4), IRAK1(3), IRAK2(5), IRAK3(9), JUN(4), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAP3K7(8), MAPK14(2), MAPK8(5), MYD88(1), NFKB1(3), NFKBIA(6), RELA(6), TGFB1(2), TGFB3(1), TNF(4), TOLLIP(3), TRAF6(1)	17179234	115	84	113	39	63	3	16	9	24	0	0.772	1.000	1.000
328	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	CSNK2A1(11), ELK1(1), EPO(2), EPOR(5), FOS(4), GRB2(1), JAK2(8), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PLCG1(12), PTPN6(2), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5)	12256623	107	83	104	34	60	5	14	12	16	0	0.635	1.000	1.000
329	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), AOC2(5), AOC3(6), ASPA(2), CNDP1(4), DDC(8), HAL(6), HARS(6), HDC(6), HNMT(2), MAOA(4), MAOB(2), PRPS1(3), PRPS2(1)	14173380	97	83	96	31	40	4	27	9	17	0	0.400	1.000	1.000
330	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	13	ERCC3(7), GTF2A1(3), GTF2B(2), GTF2E1(7), GTF2F1(5), HDAC3(1), NCOA1(24), NCOA2(12), NCOA3(16), NCOR2(19), POLR2A(13), RARA(4), TBP(2)	13867753	115	83	112	39	64	3	20	8	20	0	0.836	1.000	1.000
331	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(13), APOA1(2), APOA4(4), APOC1(1), APOC2(1), APOC3(1), APOE(2), CETP(2), CYP7A1(10), DGAT1(3), HMGCR(7), LCAT(3), LDLR(10), LIPC(6), LPL(4), LRP1(36), SCARB1(3), SOAT1(5)	15957453	113	83	113	45	57	5	22	10	19	0	0.769	1.000	1.000
332	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(6), CBS(2), CTH(5), GGT1(5), HEMK1(1), LCMT1(2), LCMT2(12), MARS(1), MARS2(5), MAT1A(4), MAT2B(1), METTL2B(3), METTL6(5), PAPSS1(4), PAPSS2(2), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SCLY(2), SEPHS1(2), SEPHS2(1), WBSCR22(6)	14482008	96	82	92	36	53	4	22	8	9	0	0.711	1.000	1.000
333	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(5), ALOX5(4), CYP1A2(4), CYP2C18(5), CYP2C19(7), CYP2C8(4), CYP2C9(3), CYP2E1(4), CYP2J2(2), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), HSD3B7(2), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), RDH12(2), RDH13(1)	13924185	96	82	96	40	43	4	21	10	18	0	0.811	1.000	1.000
334	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(7), ARHGDIB(1), BIRC2(3), BIRC3(3), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), DFFA(6), GZMB(2), LMNA(5), LMNB1(4), LMNB2(7), PRF1(7)	11239631	92	81	92	32	53	4	15	7	13	0	0.874	1.000	1.000
335	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), DDC(8), EPX(6), ESCO1(3), ESCO2(3), GOT1(2), HPD(4), LPO(8), MAOA(4), MAOB(2), MIF(1), MPO(4), NAT6(1), PNPLA3(4), PRDX6(5), SH3GLB1(1), TAT(5), TPO(16)	19882147	105	81	105	26	47	4	30	9	15	0	0.126	1.000	1.000
336	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ACADM(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), CNDP1(4), DPYD(14), DPYS(13), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), MLYCD(2), SMS(1), SRM(3), UPB1(4)	15706845	104	81	104	38	45	8	22	15	14	0	0.785	1.000	1.000
337	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), C1GALT1(4), C1GALT1C1(3), GALNT1(5), GALNT10(2), GALNT11(4), GALNT12(4), GALNT13(5), GALNT14(3), GALNT2(7), GALNT3(5), GALNT4(3), GALNT5(6), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GALNTL5(8), GCNT1(5), GCNT3(3), GCNT4(5), OGT(5), ST3GAL1(1), ST3GAL2(3), ST6GALNAC1(8), WBSCR17(9)	18825856	117	81	117	38	57	9	26	11	14	0	0.647	1.000	1.000
338	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(65), CDC25A(5), CDC25B(2), CDC25C(2), CDK2(1), CDK4(5), CHEK1(3), MYT1(10), WEE1(10), YWHAH(2)	8768849	105	81	102	24	48	6	14	13	23	1	0.410	1.000	1.000
339	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(4), DARS(3), EPRS(12), FARS2(1), GARS(6), HARS(6), IARS(6), KARS(10), LARS(11), LARS2(3), MARS(1), MARS2(5), NARS(3), QARS(5), RARS(6), SARS(5), TARS(9), WARS(5), WARS2(2), YARS(5)	18745148	112	80	112	39	66	6	14	8	18	0	0.818	1.000	1.000
340	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(8), CSF1R(11), EGF(17), EGFR(7), GRB2(1), MET(19), PDGFRA(16), PRKCA(3), SH3GLB1(1), SH3GLB2(1), SH3KBP1(8), SRC(5)	11321290	97	80	96	40	41	5	29	12	10	0	0.945	1.000	1.000
341	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(6), G6PD(3), GCLC(6), GCLM(2), GGT1(5), GPX2(1), GPX3(1), GPX5(2), GPX6(3), GPX7(4), GSR(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(3), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(4), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), IDH1(9), IDH2(2), MGST1(1), MGST2(1), MGST3(1), OPLAH(4), TXNDC12(2)	12766161	99	80	99	43	45	4	25	7	18	0	0.826	1.000	1.000
342	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(7), FADD(7), IKBKB(11), IL1A(1), IL1R1(1), IRAK1(3), MAP3K1(10), MAP3K7(8), MYD88(1), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TLR4(6), TNF(4), TNFAIP3(7), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF6(1)	14056195	102	80	100	29	59	3	12	5	23	0	0.514	1.000	1.000
343	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(5), BLVRA(5), BLVRB(1), CP(5), CPOX(5), EPRS(12), FECH(2), GUSB(3), HCCS(3), HMOX1(3), HMOX2(2), PPOX(6), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4), UROD(4), UROS(4)	15967504	102	80	102	39	46	4	17	14	21	0	0.927	1.000	1.000
344	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(2), BAX(1), CASP8(14), CYCS(1), FADD(7), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), NFKB1(3), NSMAF(12), RAF1(4), RELA(6), RIPK1(7), SMPD1(4), TNFRSF1A(5), TRADD(2), TRAF2(5)	11874769	103	79	100	29	56	4	11	11	21	0	0.420	1.000	1.000
345	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(6), ARHGEF1(8), F2(3), F2R(2), F2RL3(2), GNA12(3), GNA13(12), GNAI1(4), GNAQ(3), GNB1(7), MAP3K7(8), PIK3R1(6), PLCB1(16), PPP1R12B(10), PRKCA(3), PTK2B(6), ROCK1(8)	13712625	107	79	100	34	59	5	17	12	14	0	0.624	1.000	1.000
346	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	11	APC(29), AXIN1(4), DVL1(5), FZD1(4), GSK3B(4), HDAC1(4), LDB1(3), LEF1(4), PITX2(5), TRRAP(40)	12728636	102	79	98	26	54	5	21	6	16	0	0.201	1.000	1.000
347	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(4), ACADS(6), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), HMGCL(1), L2HGDH(4), OXCT1(4), PDHA1(5), PDHA2(6), PDHB(1), SDHB(2), SDS(2)	15013646	101	78	100	47	53	6	17	12	13	0	0.984	1.000	1.000
348	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(2), MRPS7(4), RPL10A(3), RPL10L(3), RPL11(2), RPL13(3), RPL19(2), RPL22L1(2), RPL23A(4), RPL24(3), RPL26(4), RPL28(2), RPL29(2), RPL3(1), RPL30(1), RPL31(5), RPL34(2), RPL35A(1), RPL37(1), RPL3L(3), RPL41(1), RPL6(2), RPL7(3), RPL8(2), RPL9(1), RPS10(1), RPS12(3), RPS13(2), RPS16(1), RPS18(6), RPS2(6), RPS20(2), RPS24(1), RPS26(1), RPS29(1), RPS3A(1), RPS4Y1(1), RPS5(1), RPS6(5), RPS7(2), RPS8(2), RPS9(2), RPSA(4)	13137032	101	78	100	41	54	8	25	4	10	0	0.694	1.000	1.000
349	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(10), ABCC2(12), ABCG2(10), BCHE(9), CES1(4), CES2(3), CYP3A4(9), CYP3A5(4), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3)	13357273	93	78	93	31	44	4	22	11	12	0	0.501	1.000	1.000
350	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(3), F2R(2), F2RL3(2), GNAI1(4), GNB1(7), ITGA1(7), ITGB1(3), MAP2K1(3), MAPK3(8), PLA2G4A(1), PLCB1(16), PRKCA(3), PTGS1(2), PTK2(12), RAF1(4), SRC(5), SYK(8), TBXAS1(3)	13922391	93	78	92	42	43	8	20	12	10	0	0.986	1.000	1.000
351	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(2), CR1(14), CR2(17), FCGR2B(2), HLA-DRA(4), HLA-DRB1(1), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19)	8820248	90	77	89	30	38	5	23	10	14	0	0.597	1.000	1.000
352	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(2), CALM2(2), GNAQ(3), MARCKS(2), NFATC1(13), NFATC2(13), NFATC3(10), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKCA(3), SP1(10), SP3(3), SYT1(6)	12025717	101	77	101	35	47	10	21	10	13	0	0.828	1.000	1.000
353	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(65), CDC25A(5), CDC25B(2), CDC25C(2), CHEK1(3), MYT1(10), WEE1(10), YWHAH(2)	8041527	99	77	96	22	43	6	14	13	22	1	0.405	1.000	1.000
354	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(3), APC(29), AXIN1(4), CCND1(4), CD14(3), DVL1(5), FZD1(4), GJA1(3), GNAI1(4), GSK3B(4), IRAK1(3), LBP(2), LEF1(4), LY96(1), MYD88(1), NFKB1(3), PDPK1(2), PIK3R1(6), PPP2CA(2), RELA(6), TLR4(6), TOLLIP(3)	15576605	102	77	100	37	50	3	20	4	25	0	0.927	1.000	1.000
355	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), BCAT2(3), COASY(8), DPYD(14), DPYS(13), ENPP1(7), ENPP3(5), ILVBL(3), PANK1(3), PANK2(5), PANK3(5), PANK4(7), PPCDC(1), PPCS(9), UPB1(4), VNN1(3)	10082732	94	77	90	41	43	5	20	17	9	0	0.972	1.000	1.000
356	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(12), ARHGEF1(8), GNA12(3), GNA13(12), GNAQ(3), GNB1(7), MYL2(4), MYLK(15), PLCB1(16), PPP1R12B(10), PRKCA(3), ROCK1(8)	12072772	101	77	94	29	56	3	19	15	8	0	0.602	1.000	1.000
357	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(7), APC(29), AXIN1(4), BTRC(4), DLL1(9), DVL1(5), FZD1(4), GSK3B(4), NOTCH1(17), PSEN1(8)	11315799	91	77	90	27	44	3	19	2	21	2	0.706	1.000	1.000
358	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CASP2(2), CHUK(7), CRADD(1), IKBKB(11), JUN(4), LTA(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP4K2(5), MAPK14(2), MAPK8(5), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TANK(3), TNF(4), TNFRSF1A(5), TRADD(2), TRAF2(5)	13892378	102	77	99	34	66	4	11	4	17	0	0.667	1.000	1.000
359	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(48), MAP2(15), PPP1CA(8), PPP2CA(2), PRKACB(2), PRKACG(2), PRKAG1(3), PRKAR2A(5), PRKAR2B(5), PRKCE(5)	10617251	95	76	93	19	57	4	13	13	8	0	0.324	1.000	1.000
360	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), DCXR(2), GUSB(3), RPE(1), UGDH(5), UGP2(9), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), XYLB(8)	15913885	102	76	98	29	49	7	12	16	18	0	0.484	1.000	1.000
361	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	13	APAF1(7), ATM(65), BAX(1), CCND1(4), CCNE1(3), CDK2(1), CDK4(5), E2F1(3), GADD45A(1), MDM2(6), PCNA(4)	8885815	100	76	96	22	47	5	14	11	22	1	0.333	1.000	1.000
362	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), P4HB(6), SLC23A1(1), SLC23A2(3), SLC2A1(4), SLC2A3(6)	14352855	85	76	84	40	40	6	22	6	11	0	0.999	1.000	1.000
363	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(6), CRK(4), CXCR4(4), GNAI1(4), GNAQ(3), GNB1(7), MAP2K1(3), MAPK3(8), NFKB1(3), PIK3C2G(11), PIK3R1(6), PLCG1(12), PRKCA(3), PTK2(12), PTK2B(6), PXN(3), RAF1(4), RELA(6)	14406863	105	75	104	32	55	9	17	11	13	0	0.482	1.000	1.000
364	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(5), FUCA1(2), FUCA2(6), GLB1(5), HEXA(3), HEXB(2), LCT(16), MAN2B1(8), MAN2B2(7), MAN2C1(8), MANBA(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5)	11757472	84	75	83	29	44	1	20	10	9	0	0.579	1.000	1.000
365	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(6), AP2M1(2), BAD(2), BTK(5), EEA1(13), GRASP(3), GSK3A(2), GSK3B(4), LYN(5), PDPK1(2), PFKL(1), PFKM(5), PFKP(4), PLCG1(12), PRKCE(5), PRKCZ(4), RAB5A(2), RAC1(4), RPS6KB1(4), VAV2(8)	14514204	96	75	96	32	56	5	10	13	11	1	0.537	1.000	1.000
366	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(2), ACP5(8), ACP6(2), ACPP(11), ACPT(4), ALPI(5), ALPL(4), ALPP(3), CMBL(1), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), PON1(6), PON2(2), PON3(3)	10449981	95	73	91	39	41	4	28	6	16	0	0.823	1.000	1.000
367	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(11), ELK1(1), FOS(4), GRB2(1), JUN(4), KLK2(1), MAP2K1(3), MAPK3(8), MAPK8(5), NGFR(4), PIK3R1(6), PLCG1(12), RAF1(4), SHC1(8), SOS1(23)	9588076	95	73	92	27	50	4	15	13	13	0	0.466	1.000	1.000
368	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(5), CSNK1D(3), DRD1(2), DRD2(5), GRM1(22), PLCB1(16), PPP1CA(8), PPP1R1B(5), PPP2CA(2), PPP3CA(7), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5)	9327568	98	72	98	26	48	3	23	12	12	0	0.166	1.000	1.000
369	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(5), ALDOB(3), ALDOC(2), DERA(3), FBP1(3), FBP2(2), G6PD(3), GPI(4), H6PD(12), PFKL(1), PFKM(5), PFKP(4), PGD(5), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(3), TALDO1(4), TKT(1), TKTL1(7), TKTL2(5)	14132949	87	72	87	50	37	4	26	11	9	0	0.996	1.000	1.000
370	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), AGPS(5), CHPT1(6), ENPP2(7), ENPP6(3), PAFAH1B1(2), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(4), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLD1(9), PLD2(3), PPAP2A(5), PPAP2B(3), PPAP2C(1)	13463168	89	72	89	45	47	2	11	11	18	0	0.994	1.000	1.000
371	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG5(3), ATG7(4), BECN1(2), GABARAP(3), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNG(2), PIK3C3(11), PIK3R4(11), PRKAA1(9), PRKAA2(7), ULK1(9), ULK2(9), ULK3(1)	12161636	90	72	89	25	54	7	17	7	5	0	0.412	1.000	1.000
372	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), ESRRA(2), HDAC5(6), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), PPARA(1), PPP3CA(7), PPP3CB(6), PPP3CC(4), SLC2A4(4), SYT1(6), YWHAH(2)	11670640	92	72	92	43	48	9	8	12	15	0	0.973	1.000	1.000
373	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(5), ANXA2(2), ANXA3(3), ANXA4(1), ANXA5(4), ANXA6(6), CYP11A1(1), EDN1(2), EDNRA(4), EDNRB(8), HPGD(1), HSD11B2(3), PLA2G4A(1), PRL(3), PTGDR(3), PTGDS(1), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2), PTGIS(2), PTGS1(2), PTGS2(6), S100A6(2), TBXAS1(3)	12021185	84	72	84	37	34	5	32	3	10	0	0.892	1.000	1.000
374	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(5), AGT(3), AGTR1(3), AGTR2(4), CMA1(1), COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), REN(3)	14486384	84	71	83	34	34	6	26	5	13	0	0.996	1.000	1.000
375	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(6), AKT1(3), BAD(2), BAX(1), BCL2L1(4), CSF2RB(5), IGF1(2), IGF1R(11), IL3RA(6), KIT(9), KITLG(5), PIK3R1(6), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), YWHAH(2)	11485732	82	71	81	25	23	5	22	9	23	0	0.449	1.000	1.000
376	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), ACO2(5), CS(3), DLD(7), DLST(1), FH(7), IDH1(9), IDH2(2), IDH3A(3), IDH3B(4), IDH3G(1), MDH1(3), PC(10), PCK1(9), SDHA(9), SDHB(2), SUCLA2(2), SUCLG1(2), SUCLG2(3)	12013419	86	71	86	29	48	2	20	6	10	0	0.575	1.000	1.000
377	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), DDOST(1), DPAGT1(6), DPM1(3), FUT8(7), MAN1A1(3), MAN1B1(9), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(4), MGAT5(7), RPN1(3), RPN2(5), ST6GAL1(4)	11514005	87	71	87	32	41	4	19	15	8	0	0.687	1.000	1.000
378	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(4), ADCY1(6), CAP1(7), CCNB1(5), CDC25C(2), GNAI1(4), GNAS(12), GNB1(7), MAPK3(8), MYT1(10), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RPS6KA1(5), SRC(5)	11706600	95	70	94	29	42	6	27	11	9	0	0.455	1.000	1.000
379	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(10), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), CYP2C19(7), CYP2C9(3), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ECHS1(1), EHHADH(6), ESCO1(3), ESCO2(3), HADHA(4), NAT6(1), PNPLA3(4), SH3GLB1(1), YOD1(1)	18013869	81	69	80	27	36	2	25	4	14	0	0.719	1.000	1.000
380	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(3), BAD(2), GRB2(1), IGF1R(11), IRS1(9), MAP2K1(3), MAPK3(8), PIK3R1(6), RAF1(4), SHC1(8), SOS1(23), YWHAH(2)	9562296	80	69	79	29	39	3	15	12	11	0	0.860	1.000	1.000
381	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ICAM1(7), ITGA4(19), ITGAL(17), ITGAM(13), ITGB1(3), ITGB2(7), SELE(7), SELP(7)	9229964	82	69	81	31	46	3	17	6	10	0	0.816	1.000	1.000
382	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(7), BIRC2(3), BIRC3(3), CASP10(1), CASP3(3), CASP7(5), CASP8(14), CASP9(6), DFFA(6), GZMB(2), PRF1(7), SCAP(9), SREBF1(6), SREBF2(8)	10509336	80	69	80	28	42	4	15	6	13	0	0.743	1.000	1.000
383	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(6), AGT(3), AGTR2(4), EDN1(2), EDNRA(4), EDNRB(8), EGF(17), EGFR(7), FOS(4), JUN(4), MYC(2), NFKB1(3), PLCG1(12), PRKCA(3), RELA(6)	11715209	85	68	83	37	44	8	20	4	9	0	0.935	1.000	1.000
384	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(3), ASNS(1), ASRGL1(3), CA1(3), CA12(2), CA14(1), CA2(2), CA3(1), CA4(2), CA5A(4), CA5B(3), CA6(2), CA7(1), CA8(3), CA9(3), CPS1(13), CTH(5), GLS(3), GLS2(4), GLUD1(6), GLUD2(10), GLUL(3), HAL(6)	12378382	84	68	83	28	38	6	19	8	13	0	0.717	1.000	1.000
385	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(9), IL22(1), IL22RA1(4), IL22RA2(3), JAK1(9), JAK2(8), JAK3(12), SOCS3(1), STAT1(13), STAT3(6), STAT5A(1), STAT5B(5), TYK2(9)	10651332	81	68	80	32	31	4	14	7	25	0	0.844	1.000	1.000
386	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	20	CHUK(7), DUSP1(3), IKBKB(11), IL1B(3), MAP2K3(6), MAP2K6(1), MAP3K7(8), MAPK11(5), MAPK14(2), MYD88(1), NFKB1(3), NFKBIA(6), NR3C1(6), RELA(6), TGFBR1(7), TGFBR2(8), TLR2(3), TNF(4)	11578281	90	68	89	28	48	4	11	4	22	1	0.721	1.000	1.000
387	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(8), DPYD(14), DPYS(13), ENPP1(7), ENPP3(5), PANK1(3), PANK2(5), PANK3(5), PANK4(7), PPCS(9), UPB1(4)	8119133	84	68	80	35	38	5	16	16	9	0	0.968	1.000	1.000
388	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(3), AKT2(4), AKT3(6), BPNT1(2), GRB2(1), ILK(3), MAPK3(8), PDK1(2), PIK3CD(7), PTK2B(6), RBL2(9), SHC1(8), SOS1(23)	10126383	82	68	81	23	47	3	17	7	8	0	0.364	1.000	1.000
389	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(1), ALDH18A1(3), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), ARG1(2), ARG2(3), ASL(6), ASS1(2), CPS1(13), GATM(3), MAOA(4), MAOB(2), NAGS(1), ODC1(4), OTC(2), SAT2(3), SMS(1), SRM(3)	17041271	89	67	88	28	43	3	17	12	14	0	0.360	1.000	1.000
390	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(10), EXT2(3), EXTL1(3), EXTL2(4), EXTL3(6), GLCE(5), HS2ST1(3), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), HS6ST2(2), HS6ST3(1), NDST1(2), NDST2(2), NDST3(7), NDST4(13)	11958635	75	67	75	36	38	5	15	7	10	0	0.935	1.000	1.000
391	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(2), ACP5(8), ACP6(2), ACPP(11), ACPT(4), ENPP1(7), ENPP3(5), FLAD1(8), LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), RFK(1), TYR(12)	8779717	85	67	83	28	44	4	19	7	11	0	0.804	1.000	1.000
392	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(10), CALM1(2), CALM2(2), CAPN2(2), CAPNS2(1), HDAC1(4), HDAC2(3), MEF2D(3), NFATC1(13), NFATC2(13), PPP3CA(7), PPP3CB(6), PPP3CC(4), PRKCA(3), SYT1(6)	11306315	79	67	79	32	32	10	15	9	13	0	0.946	1.000	1.000
393	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(7), DUSP1(3), IKBKAP(10), IKBKB(11), LTA(1), MAP3K1(10), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TANK(3), TNFAIP3(7), TNFRSF1B(6), TRAF2(5), TRAF3(2)	13016567	87	67	87	22	53	4	12	3	15	0	0.261	1.000	1.000
394	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(7), IFNG(2), IKBKB(11), IL2(1), JUN(4), MAP3K1(10), MAP3K5(14), MAP4K5(4), MAPK14(2), MAPK8(5), NFKB1(3), NFKBIA(6), RELA(6), TNFRSF9(2), TNFSF9(2), TRAF2(5)	11162507	85	66	83	28	53	2	12	3	15	0	0.783	1.000	1.000
395	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(3), C1R(2), C1S(8), C2(5), C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8), MASP1(8), MASP2(5), MBL2(1)	12378608	85	66	85	29	34	5	26	9	11	0	0.751	1.000	1.000
396	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(8), POLD2(3), POLE(27), POLG(8), POLQ(28)	9755657	74	66	74	18	32	5	15	7	15	0	0.232	1.000	1.000
397	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(6), G6PD(3), GCLC(6), GCLM(2), GGT1(5), GPX2(1), GPX3(1), GPX5(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(4), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), IDH1(9), IDH2(2), MGST1(1), MGST2(1), MGST3(1), PGD(5)	10468473	84	66	84	32	42	3	21	4	14	0	0.614	1.000	1.000
398	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(18), POLR1B(4), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2)	13668577	88	66	87	41	54	4	13	8	9	0	0.989	1.000	1.000
399	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(4), ADSL(4), ADSS(4), AGXT(2), AGXT2(2), ASL(6), ASNS(1), ASPA(2), CAD(15), CRAT(10), DARS(3), DDO(1), GAD1(8), GAD2(6), GOT1(2), GPT(2), GPT2(1), NARS(3), PC(10)	15154734	90	65	89	42	51	3	17	10	9	0	0.961	1.000	1.000
400	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	12	F10(5), F2(3), F2R(2), F5(24), F7(8), FGA(17), FGB(5), FGG(7), PROC(2), SERPINC1(7)	8763541	80	65	78	23	48	3	14	6	9	0	0.497	1.000	1.000
401	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(27), ACACB(20), FASN(12), MCAT(2), OLAH(4), OXSM(8)	9087372	73	65	71	20	40	6	10	10	7	0	0.194	1.000	1.000
402	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(11), ACE2(5), AGT(3), AGTR1(3), AGTR2(4), ANPEP(6), CMA1(1), CPA3(7), CTSA(2), CTSG(4), ENPEP(9), LNPEP(7), MAS1(2), MME(13), NLN(2), REN(3), THOP1(6)	12312028	88	65	86	33	40	3	19	12	14	0	0.723	1.000	1.000
403	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(9), DYRK1B(5), GLI2(16), GLI3(19), GSK3B(4), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), SHH(6), SMO(8), SUFU(2)	9663705	89	65	88	24	31	4	34	5	15	0	0.262	1.000	1.000
404	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	11	APC(29), CDH1(15), MAP2K1(3), MAP3K7(8), MAPK3(8), SKIL(15), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8)	9351384	96	65	95	16	44	3	12	7	28	2	0.117	1.000	1.000
405	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(3), HSPA1A(3), IFNG(2), IFNGR1(1), IFNGR2(6), IKBKB(11), JAK2(8), LIN7A(3), NFKB1(3), NFKBIA(6), RELA(6), TNF(4), TNFRSF1A(5), TNFRSF1B(6), USH1C(4), WT1(4)	8923474	75	65	73	23	47	3	9	2	14	0	0.527	1.000	1.000
406	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(7), ACTN2(10), BCAR1(6), CSK(7), CTNNA1(6), CTNNA2(21), PTK2(12), PXN(3), SRC(5), VCL(4)	10149658	81	64	80	23	34	7	22	9	9	0	0.355	1.000	1.000
407	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	22	GPAA1(6), GPLD1(5), PGAP1(5), PIGA(3), PIGB(5), PIGC(4), PIGF(2), PIGG(7), PIGK(4), PIGL(2), PIGM(2), PIGN(1), PIGO(11), PIGQ(5), PIGT(2), PIGU(5), PIGV(5), PIGW(5), PIGZ(3)	13116933	82	64	82	33	36	2	25	5	14	0	0.688	1.000	1.000
408	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(6), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), HEMK1(1), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), WBSCR22(6)	8727356	75	64	70	23	39	2	19	8	7	0	0.376	1.000	1.000
409	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(5), FOS(4), GRB2(1), IL3RA(6), JAK2(8), MAP2K1(3), MAPK3(8), PTPN6(2), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5)	10072656	78	64	77	29	38	3	10	9	18	0	0.852	1.000	1.000
410	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(3), HLA-A(7), ITGB1(3), KLRC2(2), KLRC3(4), KLRC4(3), KLRD1(1), LAT(1), MAP2K1(3), MAPK3(8), PAK1(4), PIK3R1(6), PTK2B(6), PTPN6(2), RAC1(4), SYK(8), VAV1(8)	9542821	73	64	72	24	31	2	14	8	18	0	0.753	1.000	1.000
411	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(3), BCAR1(6), CDKN1B(6), GRB2(1), ILK(3), ITGB1(3), MAPK3(8), PDK2(2), PDPK1(2), PIK3R1(6), PTK2(12), SHC1(8), SOS1(23)	9457637	83	64	82	22	45	4	16	6	12	0	0.537	1.000	1.000
412	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(6), CHAT(4), COMT(3), DBH(4), DDC(8), GAD1(8), GAD2(6), HDC(6), MAOA(4), PAH(11), SLC18A3(5), TH(2), TPH1(3)	8271059	72	63	72	38	25	3	24	8	12	0	0.979	1.000	1.000
413	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(3), C1R(2), C1S(8), C2(5), C3(16), C5(9), C6(9), C7(4), C8A(7), C8B(3), C9(8), MASP1(8)	12095257	82	63	82	28	34	5	25	8	10	0	0.750	1.000	1.000
414	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(5), FUCA1(2), FUCA2(6), GLB1(5), HEXA(3), HEXB(2), LCT(16), MAN2C1(8), MANBA(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5)	9523377	69	63	69	21	35	1	16	9	8	0	0.472	1.000	1.000
415	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(3), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF4E(2), EIF4EBP1(1), GSK3B(4), IGF1(2), IGF1R(11), INPPL1(11), PDK2(2), PDPK1(2), PIK3R1(6), PPP2CA(2), RPS6(5), RPS6KB1(4)	9688265	78	62	78	22	40	1	21	2	13	1	0.406	1.000	1.000
416	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), CYB5R3(4), GCK(1), GFPT1(5), GNE(8), GNPDA1(3), GNPDA2(2), HEXA(3), HEXB(2), HK1(15), HK2(11), HK3(8), PGM3(1), RENBP(4), UAP1(5)	9831287	74	61	73	33	37	6	16	5	10	0	0.958	1.000	1.000
417	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	19	CCNA1(4), CCNB1(5), CCND1(4), CCND2(1), CCND3(5), CCNE1(3), CCNH(4), CDC25A(5), CDK2(1), CDK4(5), CDK6(5), CDK7(6), CDKN1B(6), CDKN2B(2), CDKN2C(2), CDKN2D(1), E2F1(3), RBL1(9), TFDP1(2)	7746790	73	61	71	20	39	2	14	6	12	0	0.411	1.000	1.000
418	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(3), AKT1(3), ANXA1(5), CALM1(2), CALM2(2), GNAS(12), GNB1(7), NFKB1(3), NOS3(11), NPPA(2), NR3C1(6), PIK3R1(6), RELA(6), SYT1(6)	9061589	74	61	72	23	47	5	10	3	9	0	0.733	1.000	1.000
419	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(6), CHPT1(6), HEMK1(1), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PCYT1A(1), PCYT1B(2), PRMT2(1), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), WBSCR22(6)	8144103	69	61	65	21	40	3	13	7	6	0	0.477	1.000	1.000
420	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	18	AKT1(3), CCND1(4), CCNE1(3), CDK2(1), CDK4(5), CDK6(5), CDKN1B(6), E2F1(3), MAPK3(8), NFKB1(3), NFKBIA(6), PAK1(4), PIK3R1(6), RAC1(4), RAF1(4), RELA(6), TFDP1(2)	8999041	73	61	71	25	41	3	10	6	13	0	0.744	1.000	1.000
421	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(6), CD3E(2), CD3G(2), CD4(3), CSK(7), GNAS(12), GNB1(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTPRC(19), ZAP70(2)	10625410	87	60	86	33	40	5	23	10	9	0	0.795	1.000	1.000
422	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(6), CD3E(2), CD3G(2), CD4(3), CSK(7), GNAS(12), GNB1(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTPRC(19), ZAP70(2)	10625410	87	60	86	33	40	5	23	10	9	0	0.795	1.000	1.000
423	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(17), EGFR(7), MAP2K1(3), MAP3K1(10), MAPK14(2), NCOR2(19), RARA(4), THRA(2), THRB(1)	9417172	65	60	65	19	28	2	18	4	13	0	0.499	1.000	1.000
424	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(27), CPT1A(7), LEP(1), LEPR(8), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKAG1(3)	8483238	66	60	66	21	33	4	9	10	10	0	0.722	1.000	1.000
425	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), G6PD(3), GPI(4), H6PD(12), PFKM(5), PFKP(4), PGD(5), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(3), TALDO1(4), TKT(1)	11903459	71	60	71	41	30	3	22	9	7	0	0.993	1.000	1.000
426	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(7), ARHGAP5(12), ARHGDIB(1), CASP1(9), CASP10(1), CASP3(3), CASP8(14), CASP9(6), CYCS(1), GZMB(2), JUN(4), PRF1(7)	7525762	67	59	65	22	30	4	12	10	11	0	0.844	1.000	1.000
427	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(3), GRB2(1), MAPK3(8), MAPK7(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), NTRK1(6), PIK3R1(6), PLCG1(12), RPS6KA1(5), SHC1(8)	9442036	70	59	70	29	35	4	19	2	10	0	0.811	1.000	1.000
428	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(8), GALNS(3), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), HGSNAT(4), HPSE(4), HPSE2(4), HYAL2(4), IDS(4), IDUA(1), LCT(16), NAGLU(5), SPAM1(2)	11836355	70	59	70	23	40	3	11	11	5	0	0.453	1.000	1.000
429	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(3), ASNS(1), CA1(3), CA12(2), CA14(1), CA2(2), CA3(1), CA4(2), CA5A(4), CA5B(3), CA6(2), CA7(1), CA8(3), CA9(3), CPS1(13), CTH(5), GLS(3), GLS2(4), GLUD1(6), GLUL(3), HAL(6)	11083784	71	59	70	22	34	4	13	8	12	0	0.567	1.000	1.000
430	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	12	AKT1(3), AKT2(4), AKT3(6), ELK1(1), GRB2(1), MAP2K1(3), MAP2K2(5), NGFR(4), NTRK1(6), PIK3CD(7), SHC1(8), SOS1(23)	7627699	71	59	70	23	40	1	15	9	6	0	0.537	1.000	1.000
431	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(9), E2F1(3), MDM2(6), MYC(2), PIK3R1(6), POLR1A(18), POLR1B(4), POLR1C(5), POLR1D(4), RAC1(4), TBX2(7)	8712130	68	58	67	26	39	3	12	4	10	0	0.857	1.000	1.000
432	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(8), BST1(3), CD38(1), ENPP1(7), ENPP3(5), NADK(3), NADSYN1(6), NMNAT2(1), NMNAT3(1), NNMT(3), NNT(8), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), NUDT12(3), QPRT(4)	12532409	71	58	70	29	42	4	11	4	10	0	0.914	1.000	1.000
433	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(3), PSMA5(5), PSMA6(6), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC2(9), PSMC3(5), PSMD1(7), PSMD11(4), PSMD12(4), PSMD2(6), PSMD6(3)	9340626	71	58	70	24	43	1	13	8	6	0	0.779	1.000	1.000
434	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(2), GOSR1(2), SNAP23(3), SNAP25(4), SNAP29(4), STX10(3), STX11(2), STX12(3), STX16(2), STX18(2), STX19(2), STX2(5), STX3(5), STX4(3), STX5(2), STX6(2), STX7(2), STX8(2), TSNARE1(4), USE1(4), VAMP1(1), VAMP2(1), VAMP3(1), VAMP4(1), VAMP5(1), VAMP8(2), VTI1A(1), VTI1B(6), YKT6(1)	9641982	73	58	73	27	42	3	14	7	7	0	0.772	1.000	1.000
435	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(6), CD3E(2), CD3G(2), CXCR3(3), ETV5(4), IFNG(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), JAK2(8), JUN(4), MAP2K6(1), MAPK14(2), MAPK8(5), STAT4(9), TYK2(9)	10798436	73	58	71	38	36	2	15	6	14	0	0.998	1.000	1.000
436	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(7), CYP51A1(4), DHCR24(3), DHCR7(3), EBP(1), FDPS(6), GGCX(7), GGPS1(1), HMGCR(7), HSD17B7(3), IDI1(2), IDI2(4), LSS(7), MVD(4), NSDHL(3), PMVK(1), SQLE(4), TM7SF2(1), VKORC1(1)	11122542	69	57	69	20	37	3	14	8	7	0	0.272	1.000	1.000
437	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(3), ARG1(2), ARG2(3), ASL(6), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), GATM(3), GLUD1(6), NAGS(1), OAT(1), ODC1(4), OTC(2), PYCR1(3), SMS(1)	10130109	71	57	69	25	39	2	12	9	9	0	0.678	1.000	1.000
438	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), NCK1(2), NCKAP1(12), NTRK1(6), PIR(2), RAC1(4), WASF1(5), WASF2(7), WASF3(5), WASL(2)	8905019	69	56	67	23	36	3	14	5	11	0	0.818	1.000	1.000
439	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	14	CUZD1(3), FOS(4), JUN(4), MAP2K1(3), MAPK3(8), MYC(2), NFKB1(3), NFKBIA(6), PLCB1(16), PRKCA(3), RAF1(4), RELA(6), TNF(4)	8803696	66	56	64	25	35	3	12	7	9	0	0.812	1.000	1.000
440	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(5), F13A1(8), F2(3), F2R(2), FGA(17), FGB(5), FGG(7), PLAT(6), PLG(4), SERPINB2(3), SERPINE1(6)	7811469	66	56	65	19	30	2	16	10	8	0	0.529	1.000	1.000
441	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	18	AKT1(3), BAD(2), BCL2L1(4), CASP9(6), CDC42(4), CHUK(7), ELK1(1), H2AFX(3), MAP2K1(3), MAPK3(8), NFKB1(3), PIK3R1(6), RAC1(4), RAF1(4), RALA(2), RALBP1(2), RALGDS(4), RELA(6)	9242833	72	56	71	26	35	3	11	7	16	0	0.895	1.000	1.000
442	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(3), EGFR(7), IGF1R(11), MYC(2), POLR2A(13), PPP2CA(2), PRKCA(3), TEP1(14), TERF1(5), TERT(4), TNKS(6), XRCC5(1)	14863341	71	56	71	40	34	2	23	5	7	0	0.995	1.000	1.000
443	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(3), C1R(2), C1S(8), C2(5), C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8)	10164025	71	55	71	25	29	5	22	5	10	0	0.807	1.000	1.000
444	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(3), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAPK14(2), MAPK3(8), NFKB1(3), PIK3R1(6), RELA(6), SP1(10)	8961894	63	55	63	31	30	3	13	4	13	0	0.994	1.000	1.000
445	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), BHMT(1), CBS(2), CTH(5), DNMT1(11), DNMT3A(9), DNMT3B(7), MARS(1), MARS2(5), MAT1A(4), MAT2B(1), MTFMT(2), MTR(7), SRM(3), TAT(5)	11994594	65	55	65	28	32	4	15	8	6	0	0.902	1.000	1.000
446	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	13	CHUK(7), FADD(7), HDAC3(1), IKBKB(11), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF6(1)	7327537	66	55	64	18	42	1	8	3	12	0	0.351	1.000	1.000
447	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(3), CD3E(2), CD3G(2), CD8A(2), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19), THY1(3)	6263281	64	55	64	24	30	3	16	5	10	0	0.564	1.000	1.000
448	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(3), GRB2(1), KLK2(1), NTRK1(6), PIK3R1(6), PLCG1(12), PRKCA(3), SHC1(8), SOS1(23)	7565024	63	55	62	26	35	1	14	7	6	0	0.909	1.000	1.000
449	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(6), GNAS(12), GNB1(7), PPP2CA(2), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKACB(2), PRKACG(2), PRKAG1(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5)	8942055	70	54	69	16	32	6	17	8	7	0	0.207	1.000	1.000
450	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(3), B3GNT2(5), B3GNT3(1), B3GNT4(3), B3GNT5(8), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), FUT1(3), FUT2(6), FUT3(3), FUT4(3), FUT5(5), FUT6(2), FUT7(3), FUT9(3), GCNT2(2), ST3GAL6(6), ST8SIA1(2)	9371057	70	54	68	29	36	0	17	10	7	0	0.747	1.000	1.000
451	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(6), B4GALNT1(2), GLB1(5), HEXA(3), HEXB(2), LCT(16), SLC33A1(3), ST3GAL1(1), ST3GAL2(3), ST3GAL5(5), ST6GALNAC3(5), ST6GALNAC4(2), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(2)	9619087	63	54	63	31	33	2	13	11	4	0	0.938	1.000	1.000
452	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), GOT1(2), GPT(2), GPT2(1), MDH1(3), ME1(5), ME3(6), PGK1(2), PKLR(8), RPE(1), RPIA(3), TKT(1), TKTL1(7), TKTL2(5), TPI1(1)	11714053	62	54	62	31	29	1	20	8	4	0	0.947	1.000	1.000
453	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	13	FYN(7), IL2RG(5), IL7(1), IL7R(7), JAK1(9), JAK3(12), LCK(2), NMI(4), PIK3R1(6), PTK2B(6), STAT5A(1), STAT5B(5)	9293142	65	54	65	27	22	3	18	7	15	0	0.884	1.000	1.000
454	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ICAM1(7), ITGA4(19), ITGAL(17), ITGB1(3), ITGB2(7), SELE(7)	7028740	62	54	61	21	34	1	13	5	9	0	0.677	1.000	1.000
455	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(7), BAK1(2), BAX(1), BCL2L1(4), BID(2), BIK(1), BIRC2(3), BIRC3(3), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), DFFA(6), DIABLO(3)	7837497	62	54	61	23	33	4	12	1	12	0	0.930	1.000	1.000
456	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(5), DAB1(5), FYN(7), LRP8(6), RELN(36), VLDLR(6)	8197876	68	54	68	21	33	4	17	9	5	0	0.695	1.000	1.000
457	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(3), CD3E(2), CD3G(2), CD4(3), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19), THY1(3)	6570969	65	54	65	25	31	2	16	6	10	0	0.608	1.000	1.000
458	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(4), ARFGAP3(4), ARFGEF2(18), CLTA(3), CLTB(1), COPA(12), GBF1(16), GPLD1(5), KDELR2(1), KDELR3(1)	9493504	65	53	65	22	41	6	7	1	10	0	0.578	1.000	1.000
459	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(7), DUSP1(3), IKBKAP(10), IKBKB(11), MAP3K1(10), NFKB1(3), NFKBIA(6), RELA(6), TNFAIP3(7), TRAF3(2), TRAF6(1)	10519839	66	53	66	18	41	3	7	1	14	0	0.469	1.000	1.000
460	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(13), EGF(17), EGFR(7), HGS(11), RAB5A(2), TF(4), TFRC(9)	7521093	63	52	62	22	35	4	11	6	7	0	0.887	1.000	1.000
461	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(4), CLOCK(8), CRY1(3), CRY2(4), CSNK1D(3), CSNK1E(3), NPAS2(7), NR1D1(3), PER1(6), PER2(6), PER3(12)	9864281	59	52	59	25	28	1	16	4	10	0	0.947	1.000	1.000
462	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(2), CCR1(1), CCR3(3), CCR4(3), CCR5(6), CCR7(3), CD28(3), CD4(3), CXCR3(3), CXCR4(4), IFNG(2), IFNGR1(1), IFNGR2(6), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), IL2(1), IL4R(6), IL5(1), TGFB1(2), TGFB3(1)	11623419	67	52	67	33	26	2	16	13	10	0	0.942	1.000	1.000
463	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(6), CD2(2), CD33(6), CD5(3), CD7(3), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL5(1), ITGAX(3), TLR2(3), TLR4(6), TLR7(9), TLR9(6)	10838493	57	51	57	33	24	5	14	6	8	0	0.983	1.000	1.000
464	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(8), IL5(1), JUNB(5), MAF(3), MAP2K3(6), MAPK14(2), NFATC1(13), NFATC2(13), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5)	7020066	71	51	71	29	25	5	24	7	10	0	0.809	1.000	1.000
465	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(5), AFMID(4), CS(3), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(9), MTHFD2(6)	7826098	58	51	57	19	27	3	19	2	7	0	0.528	1.000	1.000
466	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(3), ATIC(2), FTCD(3), GART(7), MTFMT(2), MTHFD1(7), MTHFD1L(9), MTHFD2(6), MTHFR(4), MTHFS(2), MTR(7), SHMT1(3), SHMT2(2), TYMS(3)	11036760	63	51	63	26	30	4	14	6	9	0	0.887	1.000	1.000
467	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(3), CAT(9), GH1(3), GHR(6), IGF1(2), IGF1R(11), PIK3R1(6), SHC1(8), SOD1(4), SOD2(1), SOD3(1)	6210911	54	51	54	17	20	0	19	7	8	0	0.555	1.000	1.000
468	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), DCXR(2), GUSB(3), RPE(1), UCHL1(3), UCHL3(3), UGDH(5), UGT1A1(9), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A5(3), UGT1A6(5), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4)	10241286	61	50	61	22	27	3	10	11	10	0	0.796	1.000	1.000
469	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(3), ITPKA(4), PDE1A(8), PDE1B(4), PLCB1(16), PLCB2(6), PRL(3), TRH(6)	6429814	55	50	54	19	24	2	16	8	5	0	0.671	1.000	1.000
470	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), BAD(2), CHRNB1(6), CHRNG(2), MUSK(9), PIK3R1(6), PTK2(12), PTK2B(6), RAPSN(2), SRC(5), TERT(4), YWHAH(2)	8128490	59	49	59	17	23	7	14	5	10	0	0.292	1.000	1.000
471	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(2), EPHB1(14), FYN(7), ITGA1(7), ITGB1(3), L1CAM(8), LYN(5), RAP1B(2), SELP(7)	9223404	59	49	59	18	26	3	17	6	7	0	0.563	1.000	1.000
472	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(5), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ESCO1(3), ESCO2(3), NAT6(1), PNPLA3(4), SH3GLB1(1)	14554566	61	49	60	17	28	2	18	5	8	0	0.496	1.000	1.000
473	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(1), IL2RG(5), IL4R(6), IRS1(9), JAK1(9), JAK3(12), RPS6KB1(4), SHC1(8), STAT6(9)	8545155	66	49	66	28	30	1	16	9	9	1	0.879	1.000	1.000
474	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(6), CD2(2), CD3E(2), CD3G(2), CD4(3), CXCR3(3), IFNG(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), JAK2(8), STAT4(9), TYK2(9)	8489089	58	49	58	28	22	3	15	6	12	0	0.975	1.000	1.000
475	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(3), ATIC(2), ATP6V0C(2), GART(7), MTHFD1(7), MTHFD1L(9), MTHFD2(6), MTHFR(4), MTHFS(2), MTR(7), SHMT1(3), SHMT2(2), TYMS(3)	10448764	60	49	60	26	31	3	14	4	8	0	0.906	1.000	1.000
476	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(2), CCL2(1), CCR5(6), CXCR4(4), FOS(4), GNAQ(3), JUN(4), MAPK14(2), MAPK8(5), PLCG1(12), PRKCA(3), PTK2B(6), SYT1(6)	8024865	60	48	58	24	27	4	9	10	10	0	0.836	1.000	1.000
477	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(2), CD3G(2), GZMB(2), HLA-A(7), ICAM1(7), ITGAL(17), ITGB2(7), PRF1(7)	5075094	54	48	53	22	20	0	16	7	11	0	0.651	1.000	1.000
478	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(5), CS(3), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(9), MTHFD2(6)	7473972	54	48	53	19	25	2	19	2	6	0	0.644	1.000	1.000
479	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT2(5), B3GAT3(3), B4GALT7(1), CHPF(4), CHST11(2), CHST12(3), CHST14(3), CHST7(2), CHSY1(9), DSE(6), UST(4), XYLT1(6), XYLT2(6)	7961671	55	48	52	30	29	2	13	5	6	0	0.936	1.000	1.000
480	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(5), ACAT2(1), ACOT11(10), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ECHS1(1), EHHADH(6), ESCO1(3), ESCO2(3), FN3K(2), GCDH(5), HADHA(4), NAT6(1), PNPLA3(4), SH3GLB1(1), YOD1(1)	15167842	62	48	61	24	33	1	15	3	10	0	0.925	1.000	1.000
481	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), BHMT(1), CBS(2), CTH(5), DNMT1(11), DNMT3A(9), DNMT3B(7), MARS(1), MARS2(5), MAT1A(4), MAT2B(1), MTR(7)	10102031	55	48	55	23	27	3	14	7	4	0	0.847	1.000	1.000
482	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(7), ITGAL(17), ITGAM(13), ITGB2(7), SELE(7)	5987153	53	48	52	23	29	1	14	3	6	0	0.772	1.000	1.000
483	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(9), JAK2(8), JAK3(12), PIAS1(3), PIAS3(5), PTPRU(7), REG1A(8), SOAT1(5)	7938106	58	48	58	19	25	2	18	3	10	0	0.544	1.000	1.000
484	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), BAD(2), CASP9(6), CHUK(7), GH1(3), GHR(6), NFKB1(3), NFKBIA(6), PDPK1(2), PIK3R1(6), PPP2CA(2), RELA(6), YWHAH(2)	6893126	54	47	54	14	28	4	10	2	10	0	0.502	1.000	1.000
485	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	10	ARNT(9), EPO(2), EPOR(5), GRIN1(7), HIF1A(6), JAK2(8), NFKB1(3), NFKBIA(6), RELA(6), SOD2(1)	7108240	53	47	52	14	33	3	6	3	8	0	0.495	1.000	1.000
486	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(8), GALNS(3), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), IDS(4), IDUA(1), LCT(16), NAGLU(5)	8306878	52	47	52	15	31	3	8	7	3	0	0.304	1.000	1.000
487	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), AOC2(5), AOC3(6), CES1(4), DDHD1(11), ESCO1(3), ESCO2(3), LIPA(3), NAT6(1), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(5), SH3GLB1(1)	14716988	53	47	53	13	29	4	9	7	4	0	0.371	1.000	1.000
488	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(9), JAK2(8), JAK3(12), MAPK3(8), STAT3(6), TYK2(9)	6769111	52	47	52	24	20	4	12	3	13	0	0.937	1.000	1.000
489	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), GOT1(2), GPT(2), GPT2(1), MDH1(3), ME1(5), ME2(1), ME3(6), PGK1(2), PKLR(8), RPE(1), RPIA(3), TKT(1), TPI1(1)	10461276	51	46	51	26	25	1	16	6	3	0	0.947	1.000	1.000
490	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(15), KHK(1), LCT(16), MPI(7), PGM1(3), PYGL(4), PYGM(13), TPI1(1), TREH(1)	7756453	61	46	60	26	32	3	16	5	5	0	0.732	1.000	1.000
491	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(10), ACO1(4), ACO2(5), ACSS1(7), ACSS2(2), FH(7), IDH1(9), IDH2(2), MDH1(3), SUCLA2(2)	7760514	51	46	51	31	26	3	6	9	7	0	0.991	1.000	1.000
492	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(16), ABCB11(4), ABCB4(11), ABCC1(10), ABCC3(15), GSTP1(2)	8339112	58	46	57	20	34	4	10	5	5	0	0.361	1.000	1.000
493	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(2), ACP5(8), ACPP(11), ACPT(4), ENPP1(7), ENPP3(5), FLAD1(8), RFK(1), TYR(12)	5664987	59	46	57	23	29	3	15	3	9	0	0.897	1.000	1.000
494	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(1), JAK1(9), PTPRU(7), REG1A(8), STAT1(13), STAT2(4), TYK2(9)	7270570	53	46	52	21	17	3	17	4	11	1	0.681	1.000	1.000
495	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8)	7318348	53	45	53	19	24	5	16	4	4	0	0.851	1.000	1.000
496	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(1), EHHADH(6), HADH(5), HADHA(4), HSD17B10(1), HSD17B4(5), NTAN1(2), SIRT1(9), SIRT2(2), SIRT5(3), SIRT7(4), VNN2(4)	6900744	48	45	46	15	32	3	3	3	7	0	0.753	1.000	1.000
497	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(3), FH(7), IDH2(2), MDH1(3), OGDH(21), SDHA(9), SUCLA2(2)	5497154	52	45	49	16	25	3	11	7	6	0	0.451	1.000	1.000
498	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(7), DLL1(9), FURIN(9), NOTCH1(17), PSEN1(8)	5199560	50	45	48	16	22	3	15	1	7	2	0.461	1.000	1.000
499	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(7), BRAF(9), CAMP(1), CREB5(10), RAF1(4), SNX13(5), SRC(5), TERF2IP(4)	6451866	49	45	49	16	21	3	7	11	7	0	0.754	1.000	1.000
500	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(3), CD86(6), HLA-DRA(4), HLA-DRB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), IL2(1), IL2RA(1), IL4R(6)	7382887	47	45	47	19	18	2	13	8	6	0	0.855	1.000	1.000
501	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(5), CTSD(6), ESR1(5), GREB1(16), HSPB1(1), HSPB2(4), MTA1(5), MTA3(1), PDZK1(2), TUBA8(2)	6210655	47	44	46	16	15	2	23	2	5	0	0.443	1.000	1.000
502	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(8), CD38(1), ENPP1(7), ENPP3(5), NADSYN1(6), NMNAT2(1), NNMT(3), NNT(8), NT5C(1), NT5E(6), QPRT(4)	8467349	50	44	49	19	30	3	7	4	6	0	0.818	1.000	1.000
503	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(5), GALNT10(2), GALNT2(7), GALNT3(5), GALNT4(3), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GCNT1(5), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), WBSCR17(9)	8417000	59	44	59	20	28	5	15	5	6	0	0.615	1.000	1.000
504	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(2), FOS(4), JUN(4), MAPK3(8), OPRK1(4), POLR2A(13), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5)	7475395	55	43	53	20	28	3	13	3	8	0	0.687	1.000	1.000
505	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(9), ASPH(3), COPS5(1), EDN1(2), EPO(2), HIF1A(6), JUN(4), NOS3(11), P4HB(6), VHL(2)	6954471	46	43	44	22	29	2	3	5	7	0	0.984	1.000	1.000
506	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(14), ANKRD1(1), CYR61(6), DUSP14(4), EIF4E(2), EIF4EBP1(1), HBEGF(1), IFNG(2), IFRD1(6), IL1A(1), IL1R1(1), JUND(2), MYOG(2), NR4A3(4), WDR1(3)	6208349	50	43	47	16	31	3	6	3	7	0	0.646	1.000	1.000
507	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADS(6), ACADVL(2), ACSL1(3), ACSL3(2), ACSL4(2), CPT1A(7), CPT2(5), EHHADH(6), HADHA(4), SCP2(4), SLC25A20(3)	9805244	47	43	47	16	25	1	10	6	5	0	0.727	1.000	1.000
508	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PIK3R1(6), PLCB1(16), PLCG1(12), PRKCA(3), VAV1(8)	6218607	48	43	48	17	26	1	13	3	5	0	0.708	1.000	1.000
509	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(15), HK2(11), HK3(8), IMPA1(1), IMPA2(4), ISYNA1(2), PGM1(3), PGM3(1), TGDS(3)	6757795	49	42	48	25	21	3	12	3	10	0	0.963	1.000	1.000
510	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(7), CASP3(3), CASP9(6), CYCS(1), DAXX(9), FAS(1), FASLG(1), HSPB1(1), HSPB2(4), IL1A(1), MAPKAPK2(1), MAPKAPK3(3), TNF(4)	6605523	46	42	46	25	21	5	12	1	7	0	0.991	1.000	1.000
511	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), SDS(2)	7052603	46	42	45	19	24	2	8	4	8	0	0.795	1.000	1.000
512	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(3), CD3E(2), CD3G(2), IFNG(2), IL2(1), IL2RA(1), TGFB1(2), TGFB3(1), TGFBR1(7), TGFBR2(8), TGFBR3(10), TOB1(5), TOB2(2)	6161601	46	42	46	20	21	3	9	2	10	1	0.922	1.000	1.000
513	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(2), UBE2A(2), UBE2B(2), UBE2C(3), UBE2D1(2), UBE2D2(1), UBE2D3(3), UBE2E3(1), UBE2H(3), UBE2I(1), UBE2J1(5), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(3), UBE2N(4), UBE2S(2), UBE3A(10)	6125902	50	42	48	18	27	5	5	8	5	0	0.849	1.000	1.000
514	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(7), CDO1(2), CTH(5), GOT1(2), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), MPST(1), SDS(2), SULT1B1(5), SULT1C2(4), SULT1C4(4)	7304186	46	41	45	16	23	5	9	2	7	0	0.712	1.000	1.000
515	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(4), ACOX1(6), ACOX3(7), ELOVL2(2), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(2), FASN(12), HADHA(4), HSD17B12(3), SCD(2)	8249688	47	41	47	21	20	3	10	5	9	0	0.777	1.000	1.000
516	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(6), ADRB2(3), GNAS(12), PLCE1(10), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RAP2B(1)	8621275	52	41	52	20	22	2	15	5	8	0	0.830	1.000	1.000
517	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(4), CNR2(6), DNMT1(11), MTNR1A(4), MTNR1B(1), PTAFR(1), PTGDR(3), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2)	6441056	51	41	51	25	22	4	17	2	6	0	0.695	1.000	1.000
518	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CAMKK1(3), CAMKK2(5), SYT1(6)	6669495	50	40	50	30	27	4	4	5	10	0	0.997	1.000	1.000
519	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), NAT1(4), NAT2(1), XDH(11)	4683662	42	40	40	15	24	2	8	5	3	0	0.432	1.000	1.000
520	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(3), CD3E(2), CD3G(2), CD80(2), CD86(6), CTLA4(1), GRB2(1), HLA-DRA(4), HLA-DRB1(1), ICOS(2), IL2(1), ITK(6), LCK(2), PIK3R1(6), PTPN11(4)	6209393	43	39	43	13	18	1	12	7	5	0	0.596	1.000	1.000
521	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(6), CAPN1(5), CAPNS2(1), CDK5(3), CDK5R1(5), CSNK1A1(6), CSNK1D(3), GSK3B(4), MAPT(10), PPP2CA(2)	5334023	45	39	45	28	22	1	10	3	9	0	0.999	1.000	1.000
522	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(11), AGT(3), AGTR1(3), AGTR2(4), BDKRB2(2), KNG1(5), NOS3(11), REN(3)	5659014	42	38	41	20	19	2	12	4	5	0	0.803	1.000	1.000
523	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(3), CASP7(5), DFFA(6), GZMB(2), HMGB1(4), HMGB2(6), TOP2A(13), TOP2B(5)	5161152	44	38	44	13	28	2	5	5	4	0	0.836	1.000	1.000
524	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(5), ALAS1(12), ALAS2(3), CPOX(5), FECH(2), PPOX(6), UROD(4), UROS(4)	4349525	41	38	41	19	20	3	4	6	8	0	0.968	1.000	1.000
525	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(5), B3GNT7(1), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), CHST1(2), CHST2(1), CHST4(3), CHST6(1), FUT8(7), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1)	7249622	43	38	42	31	21	0	9	9	4	0	0.997	1.000	1.000
526	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(5), IFNB1(1), JAK1(9), STAT1(13), STAT2(4), TYK2(9)	6297014	44	38	43	16	15	3	9	3	13	1	0.656	1.000	1.000
527	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15(5), ALOX15B(3), ALOX5(4), DPEP1(2), GGT1(5), LTA4H(3), PLA2G2A(2), PLA2G6(4), PTGDS(1), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3)	8658093	44	37	44	24	19	2	10	5	8	0	0.915	1.000	1.000
528	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(7), ERBB4(11), NRG2(2), NRG3(8), PRKCA(3), PSEN1(8)	5238652	39	37	39	11	15	2	10	4	8	0	0.581	1.000	1.000
529	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), GSS(7), NFKB1(3), NOX1(4), RELA(6), SOD1(4), TNF(4), XDH(11)	5747866	41	37	41	12	23	0	10	1	7	0	0.283	1.000	1.000
530	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), ADSS(4), HPRT1(1), IMPDH1(1), MTHFD2(6), NME2(1), OAZ1(4), POLD1(8), POLG(8), PRPS2(1), RRM1(4), SRM(3)	7223915	45	37	45	13	20	6	13	1	5	0	0.485	1.000	1.000
531	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(13), POLR2B(10), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5)	7771103	46	37	46	26	29	2	5	6	4	0	0.993	1.000	1.000
532	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(4), CCNA2(3), CCND1(4), CCNE1(3), CCNE2(7), CDK2(1), CDK4(5), CDKN1B(6), E2F1(3), E2F2(4), E2F4(2), PRB1(2)	4851391	44	37	43	12	22	2	7	2	11	0	0.493	1.000	1.000
533	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(15), HK2(11), HK3(8), IMPA1(1), PGM1(3), PGM3(1), TGDS(3)	5940854	43	37	42	22	19	3	10	2	9	0	0.962	1.000	1.000
534	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	10	CARM1(6), NCOA3(16), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RARA(4)	5865116	46	36	45	15	18	3	10	5	10	0	0.696	1.000	1.000
535	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(4), AASDH(13), AASS(11), KARS(10)	4073260	38	36	38	12	23	3	7	3	2	0	0.808	1.000	1.000
536	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(3), PSMA5(5), PSMA6(6), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMB8(4), PSMB9(2)	5099611	40	36	39	14	24	1	8	5	2	0	0.756	1.000	1.000
537	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(9), HSD17B1(1), HSD17B2(6), HSD17B3(1), HSD17B4(5), HSD17B7(3), HSD3B1(5), HSD3B2(5)	4720980	38	36	38	15	22	2	5	5	4	0	0.775	1.000	1.000
538	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(2), GPR161(7), GPR171(3), GPR18(3), GPR39(4), GPR45(4), GPR65(3), GPR68(4), GPR75(9)	5743118	39	35	38	18	18	3	9	5	4	0	0.544	1.000	1.000
539	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(6), ACOX3(7), FADS2(2), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4)	5864885	39	35	39	23	17	0	9	4	9	0	0.985	1.000	1.000
540	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(3), CSF1(4), CSF3(1), HLA-DRA(4), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL15(1), IL1A(1), IL2(1), IL5(1), IL6(4), IL7(1), LTA(1), TGFB1(2), TGFB3(1), TNF(4)	7668150	39	35	39	16	22	0	10	3	4	0	0.608	1.000	1.000
541	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(5), CAMK1G(4), HDAC9(8), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MYOD1(1), YWHAH(2)	4358814	38	35	38	15	17	5	5	4	7	0	0.851	1.000	1.000
542	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(7), MAPK14(2), MAPK8(5), NFKB1(3), RELA(6), TNFRSF13B(1), TNFRSF13C(3), TNFRSF17(2), TNFSF13(2), TNFSF13B(5), TRAF2(5), TRAF3(2), TRAF5(1), TRAF6(1)	8408660	45	35	45	14	30	1	7	2	5	0	0.584	1.000	1.000
543	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(12), GNB1(7), PRKACB(2), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3)	5599472	46	34	45	12	21	5	11	5	4	0	0.431	1.000	1.000
544	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(5), ALAS1(12), ALAS2(3), CPO(3), FECH(2), GATA1(6), HBB(1), UROD(4), UROS(4)	4456460	40	34	40	15	19	4	4	4	9	0	0.838	1.000	1.000
545	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(10), CS(3), MDH1(3), ME1(5), PC(10), PDHA1(5), SLC25A1(1), SLC25A11(2)	5386137	39	34	39	25	21	0	11	4	3	0	0.983	1.000	1.000
546	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(6), CREM(2), FHL5(4), FSHB(1), FSHR(5), GNAS(12), XPO1(7)	5604723	37	33	37	15	20	0	7	4	6	0	0.895	1.000	1.000
547	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(3), NFKB1(3), NFKBIA(6), PLCB1(16), PRKCA(3), RELA(6)	4778112	37	33	37	11	24	1	8	3	1	0	0.559	1.000	1.000
548	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(7), BAD(2), BAK1(2), BAX(1), BCL10(3), BCL2L1(4), BCL2L11(3), BID(2), CASP9(6), CES1(4)	6211003	34	33	33	10	8	5	9	2	10	0	0.830	1.000	1.000
549	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7)	4626946	33	32	32	13	15	1	8	4	5	0	0.677	1.000	1.000
550	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(20), GNA12(3), PRKACB(2), PRKACG(2), PRKAG1(3), PRKAR2A(5), PRKAR2B(5)	5886779	40	32	40	11	20	1	8	5	6	0	0.584	1.000	1.000
551	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH9A1(7)	4626946	33	32	32	13	15	1	8	4	5	0	0.677	1.000	1.000
552	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(3), CDK5R1(5), EGR1(7), KLK2(1), MAP2K1(3), MAP2K2(5), MAPK3(8), NGFR(4), RAF1(4)	4505889	40	32	40	22	15	3	10	6	6	0	0.965	1.000	1.000
553	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(3), FUT1(3), FUT2(6), FUT9(3), GLA(3), HEXA(3), HEXB(2), NAGA(3), ST3GAL1(1), ST3GAL2(3), ST8SIA1(2)	6224947	34	32	34	18	15	0	12	3	4	0	0.926	1.000	1.000
554	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(2), ENO3(4), FARS2(1), GOT1(2), PAH(11), TAT(5), YARS(5)	4853154	33	32	33	12	11	1	5	7	9	0	0.692	1.000	1.000
555	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(5), CCNH(4), CDC25A(5), CDC25B(2), CDC25C(2), CDK7(6), MNAT1(4), SHH(6), XPO1(7)	5052462	41	32	40	15	28	2	5	1	5	0	0.893	1.000	1.000
556	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), CBS(2), CTH(5), GGT1(5), MARS(1), MARS2(5), MAT1A(4), MAT2B(1), PAPSS1(4), PAPSS2(2), SCLY(2), SEPHS1(2)	7181033	35	32	35	20	17	2	11	1	4	0	0.965	1.000	1.000
557	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(6), JAK1(9), JAK2(8), TYK2(9)	6104608	34	32	34	16	9	2	9	6	8	0	0.957	1.000	1.000
558	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(6), JAK1(9), JAK2(8), TYK2(9)	6104608	34	32	34	16	9	2	9	6	8	0	0.957	1.000	1.000
559	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(4), NDUFA5(1), NDUFA8(4), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFS1(5), NDUFS2(3), NDUFV1(4), NDUFV2(6)	4039204	37	32	35	12	24	0	7	2	4	0	0.763	1.000	1.000
560	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(6), CHAT(4), CHKA(5), PCYT1A(1), PDHA1(5), PDHA2(6), PEMT(1), SLC18A3(5)	3996273	33	31	33	21	11	2	13	4	3	0	0.984	1.000	1.000
561	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(7), CYCS(1), GPD2(9), NDUFA1(1), SDHA(9), SDHB(2), SDHC(2), SDHD(3), UQCRC1(2)	3866268	36	31	36	13	17	2	12	2	3	0	0.815	1.000	1.000
562	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(3), GPI(4), HK1(15), PFKL(1), PGAM1(1), PGK1(2), PKLR(8), TPI1(1)	5368723	38	31	38	21	17	1	12	4	4	0	0.936	1.000	1.000
563	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	MMP14(4), MMP2(7), MMP9(6), RECK(8), TIMP2(4), TIMP4(3)	4122794	32	31	32	20	18	3	8	2	1	0	0.986	1.000	1.000
564	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(5), FH(7), IDH1(9), IDH2(2), MDH1(3), SDHB(2), SUCLA2(2)	5199412	34	31	34	14	19	2	5	5	3	0	0.820	1.000	1.000
565	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	10	ANP32A(6), APEX1(1), DFFA(6), GZMA(4), GZMB(2), HMGB2(6), NME1(1), PRF1(7), SET(2)	3402970	35	31	35	16	19	1	7	5	3	0	0.933	1.000	1.000
566	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(2), CD4(3), FYN(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PTPRC(19), ZAP70(2)	5270758	42	31	42	21	18	0	13	7	4	0	0.962	1.000	1.000
567	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CCL3(2), CSF3(1), EPO(2), FLT3(10), IGF1(2), IL1A(1), IL6(4), KITLG(5), TGFB1(2), TGFB3(1)	4762675	30	30	30	11	18	1	7	0	4	0	0.635	1.000	1.000
568	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(3), FUT2(6), FUT9(3), GLA(3), HEXA(3), HEXB(2), NAGA(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), ST8SIA1(2)	5858469	31	30	31	18	12	0	11	3	5	0	0.958	1.000	1.000
569	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(5), ACAT2(1), BDH2(3), HMGCL(1), HMGCS1(9), HMGCS2(7), OXCT1(4), OXCT2(2)	4204082	32	30	32	12	16	2	6	5	3	0	0.827	1.000	1.000
570	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(7), SRP19(1), SRP54(2), SRP68(12), SRP72(6), SRP9(1), SRPR(3)	4424152	32	29	32	10	19	1	2	5	5	0	0.686	1.000	1.000
571	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(6), GNAS(12), GNB1(7), PRKACA(2), PRKAR1A(3)	3861208	30	28	29	14	15	3	7	2	3	0	0.887	1.000	1.000
572	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	ARF3(1), CCND1(4), CDK2(1), CDK4(5), CDKN1B(6), CFL1(1), E2F1(3), E2F2(4), MDM2(6), PRB1(2)	3879631	33	28	32	17	15	1	6	2	9	0	0.973	1.000	1.000
573	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(6), CKM(5), EIF4E(2), FBL(2), GPT(2), LDHB(2), LDHC(4), MAPK14(2), NCL(3)	5229814	28	28	28	15	18	2	6	1	1	0	0.962	1.000	1.000
574	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(5), CDC25A(5), CDC25B(2), CDC25C(2), CSK(7), GRB2(1), PRKCA(3), PTPRA(2), SRC(5)	5374586	32	28	32	26	20	2	8	2	0	0	1.000	1.000	1.000
575	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(3), CD36(2), FOS(4), FYN(7), JUN(4), MAPK14(2), THBS1(8)	4319310	30	28	28	13	14	0	9	4	3	0	0.911	1.000	1.000
576	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(4), CLOCK(8), CRY1(3), CRY2(4), CSNK1E(3), PER1(6)	4876676	28	27	28	10	11	0	9	2	6	0	0.823	1.000	1.000
577	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), HSD3B7(2), PON1(6), PON2(2), PON3(3), RDH12(2), RDH13(1)	5235485	32	27	30	18	11	0	13	2	6	0	0.949	1.000	1.000
578	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), B4GALT7(1), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), XYLT1(6), XYLT2(6)	3691193	26	26	24	17	13	2	6	1	4	0	0.903	1.000	1.000
579	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), B4GALT7(1), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), XYLT1(6), XYLT2(6)	3691193	26	26	24	17	13	2	6	1	4	0	0.903	1.000	1.000
580	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(1), HADH(5), HADHA(4), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(6), PPT1(1), PPT2(4)	4925239	33	26	31	10	24	3	2	1	3	0	0.506	1.000	1.000
581	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	6	LPL(4), NR3C1(6), PPARG(13), TNF(4)	2844644	27	26	24	13	15	0	5	2	5	0	0.931	1.000	1.000
582	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(1), ALDH7A1(1), ALDH9A1(7), UGDH(5)	4923620	27	25	27	13	10	2	5	5	5	0	0.874	1.000	1.000
583	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(2), CHST12(3), PAPSS1(4), PAPSS2(2), SULT1A1(3), SULT1A2(1), SULT1E1(1), SULT2A1(4), SULT2B1(2), SUOX(3)	5384806	27	25	26	20	16	2	4	4	1	0	0.997	1.000	1.000
584	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), FUT8(7), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1)	4571457	28	25	28	13	14	0	6	5	3	0	0.834	1.000	1.000
585	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(4), IL1B(3), MST1R(16), TNF(4)	3802040	28	25	28	18	11	1	7	2	7	0	0.971	1.000	1.000
586	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	11	FOS(4), JUN(4), KEAP1(9), MAFG(1), MAFK(1), MAPK14(2), MAPK8(5), PRKCA(3)	4379987	29	24	27	19	17	0	5	2	5	0	0.995	1.000	1.000
587	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(4), AASS(11), KARS(10)	2758501	25	24	25	11	18	1	4	1	1	0	0.957	1.000	1.000
588	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(3), CDO1(2), CSAD(3), GAD1(8), GAD2(6), GGT1(5)	3329217	27	24	27	14	11	2	8	2	4	0	0.932	1.000	1.000
589	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(3), CD3E(2), CD3G(2), CD4(3), CD58(1), CD8A(2), CSF3(1), IL6(4), KITLG(5)	3612454	25	22	25	13	11	2	7	1	4	0	0.920	1.000	1.000
590	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(4), GAD1(8), HDC(6), TH(2), TPH1(3)	3446149	23	22	23	12	11	1	6	1	4	0	0.913	1.000	1.000
591	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(6), PARK2(4), SNCA(1), SNCAIP(7), UBE2E2(1), UBE2F(1), UBE2L3(2), UBE2L6(2)	3754340	24	22	24	10	11	3	3	3	4	0	0.877	1.000	1.000
592	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(5), ACAT2(1), ECHS1(1), EHHADH(6), GCDH(5), HADHA(4), SDHB(2), SDS(2)	4551112	26	21	26	13	17	1	2	1	5	0	0.955	1.000	1.000
593	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ESCO1(3), ESCO2(3), NAT6(1), PNPLA3(4), SH3GLB1(1)	9685560	27	21	26	12	10	1	11	2	3	0	0.948	1.000	1.000
594	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(12), PRKCA(3), PTK2B(6)	3907826	22	20	22	14	11	2	5	2	2	0	0.944	1.000	1.000
595	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(3), CASP8(14), CFL1(1), CFLAR(2)	2251441	20	20	20	10	10	1	2	2	5	0	0.907	1.000	1.000
596	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(4), MYC(2), SP1(10), SP3(3), WT1(4)	3627151	23	20	23	14	10	3	1	5	4	0	0.988	1.000	1.000
597	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(4), NR1I3(4), PTGS1(2), PTGS2(6)	3136003	20	19	20	10	9	3	4	2	2	0	0.787	1.000	1.000
598	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(5), ALPL(4), ALPP(3), FPGS(4), GCH1(1), GGH(3)	3683789	20	19	20	12	10	0	8	1	1	0	0.875	1.000	1.000
599	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(3), FUT1(3), FUT2(6), FUT9(3), GCNT2(2), ST8SIA1(2)	3559098	19	18	19	13	8	0	7	3	1	0	0.962	1.000	1.000
600	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(3), GRIA2(7), JUND(2), PPP1R1B(5)	2161565	20	18	20	13	11	0	4	3	2	0	0.988	1.000	1.000
601	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(6), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), ST3GAL5(5), ST6GALNAC4(2), ST8SIA1(2)	3277672	20	18	20	10	7	0	3	7	3	0	0.816	1.000	1.000
602	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(4), COQ5(5), COQ6(7), NDUFA12(1), NDUFA13(1)	2310212	20	18	20	10	11	3	2	1	3	0	0.946	1.000	1.000
603	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(3), BMPR1B(4), BMPR2(9)	3642933	21	18	21	11	11	1	2	1	6	0	0.971	1.000	1.000
604	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(3), CD8A(2), CSF1(4), CSF3(1), EPO(2), IL2(1), IL5(1), IL6(4), IL7(1)	3489735	19	18	19	10	11	1	5	2	0	0	0.834	1.000	1.000
605	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(3), GBA(4), GGT1(5), SHMT1(3), SHMT2(2)	3137199	17	16	17	13	5	1	7	1	3	0	0.987	1.000	1.000
606	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), CBS(2), CTH(5), MUT(9)	2855059	17	16	17	5	11	1	2	3	0	0	0.620	1.000	1.000
607	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(4), PAPSS2(2), SULT1A2(1), SULT1E1(1), SULT2A1(4), SUOX(3)	3581651	17	16	17	12	9	1	4	2	1	0	0.994	1.000	1.000
608	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYA(2), NFYB(1), NFYC(1), SP1(10), SP3(3)	2879950	17	14	17	11	8	1	1	3	4	0	0.983	1.000	1.000
609	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(6), ALDH1A2(6)	2281033	12	12	11	6	7	0	3	2	0	0	0.836	1.000	1.000
610	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(5), PRKCA(3), TGM2(2)	2861448	11	11	11	12	5	0	3	2	1	0	0.997	1.000	1.000
611	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(6), CD28(3), CD3E(2), CD3G(2), CD4(3)	1881739	16	11	16	10	5	1	4	4	2	0	0.934	1.000	1.000
612	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(2), GGT1(5), SHMT1(3), SHMT2(2)	2375220	12	10	12	10	4	0	5	0	3	0	0.975	1.000	1.000
613	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(4), HSD3B7(2), RDH12(2), RDH13(1)	2776382	10	9	10	12	5	2	1	1	1	0	0.997	1.000	1.000
614	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3), PGLYRP2(2)	1049299	5	5	5	5	2	2	1	0	0	0	0.975	1.000	1.000
615	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(1)	960891	1	1	1	2	1	0	0	0	0	0	0.982	1.000	1.000
616	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		421699	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000