E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.031 0.091 -9999.0 0.0 -0.448 14.0 14.0 KLHL20 -0.013 0.039 -9999.0 0.0 -0.206 3.0 3.0 CYFIP2 -0.0 0.095 -9999.0 0.0 -0.569 11.0 11.0 Rac1/GDP 0.058 0.059 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.032 0.091 -9999.0 0.0 -0.448 14.0 14.0 AP1M1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.006 0.032 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.011 0.029 -9999.0 0.0 -0.194 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.025 0.075 -9999.0 0.0 -0.316 18.0 18.0 RAPGEF1 0.046 0.08 -9999.0 0.0 -0.377 14.0 14.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.022 0.093 -9999.0 0.0 -0.469 14.0 14.0 CRK 0.04 0.086 -9999.0 0.0 -0.415 14.0 14.0 E-cadherin/gamma catenin/alpha catenin 0.016 0.075 -9999.0 0.0 -0.36 15.0 15.0 alphaE/beta7 Integrin 0.018 0.047 -9999.0 0.0 -0.408 5.0 5.0 IQGAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.03 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.032 0.091 -9999.0 0.0 -0.448 14.0 14.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.005 0.024 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.027 0.032 -9999.0 0.0 -0.296 4.0 4.0 PI3K -0.006 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.007 0.087 -9999.0 0.0 -0.431 15.0 15.0 TIAM1 0.011 0.05 -9999.0 0.0 -0.569 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.025 0.058 -9999.0 0.0 -0.281 14.0 14.0 AKT1 -0.003 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.014 0.029 -9999.0 0.0 -0.569 1.0 1.0 CDH1 -0.004 0.106 -9999.0 0.0 -0.569 14.0 14.0 RhoA/GDP 0.058 0.059 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.04 0.045 -9999.0 0.0 -0.152 2.0 2.0 CDC42/GDP 0.058 0.059 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.018 0.058 -9999.0 0.0 -0.271 15.0 15.0 ITGB7 0.008 0.064 -9999.0 0.0 -0.569 5.0 5.0 RAC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.027 0.062 -9999.0 0.0 -0.299 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.016 0.058 -9999.0 0.0 -0.29 14.0 14.0 mol:GDP 0.054 0.066 -9999.0 0.0 -0.296 13.0 13.0 CDC42/GTP/IQGAP1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.013 0.041 -9999.0 0.0 -0.569 2.0 2.0 p120 catenin/RhoA/GDP -0.006 0.048 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.026 0.056 -9999.0 0.0 -0.192 21.0 21.0 NME1 0.014 0.026 -9999.0 0.0 -0.507 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.032 0.091 -9999.0 0.0 -0.448 14.0 14.0 regulation of cell-cell adhesion -0.005 0.029 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.005 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.007 0.037 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.03 0.077 -9999.0 0.0 -0.571 2.0 2.0 CCND1 0.03 0.068 -9999.0 0.0 -0.238 21.0 21.0 VAV2 0.041 0.099 -9999.0 0.0 -0.437 16.0 16.0 RAP1/GDP 0.055 0.052 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.032 0.088 -9999.0 0.0 -0.434 14.0 14.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.038 0.074 -9999.0 0.0 -0.544 2.0 2.0 E-cadherin/beta catenin -0.013 0.068 -9999.0 0.0 -0.376 14.0 14.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.03 0.091 -9999.0 0.0 -0.448 14.0 14.0 PIK3CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.02 0.062 -9999.0 0.0 -0.334 3.0 3.0 E-cadherin/beta catenin/alpha catenin 0.018 0.068 -9999.0 0.0 -0.338 14.0 14.0 ITGAE 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.016 0.087 -9999.0 0.0 -0.479 14.0 14.0