Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.059 0.241 -9999.0 0.0 -0.612 53.0 53.0 IHH -0.058 0.182 -9999.0 0.0 -0.519 52.0 52.0 SHH Np/Cholesterol/GAS1 -0.176 0.198 -9999.0 0.0 -0.345 221.0 221.0 LRPAP1 0.014 0.026 -9999.0 0.0 -0.507 1.0 1.0 dorsoventral neural tube patterning 0.175 0.197 0.343 221.0 -9999.0 0.0 221.0 SMO/beta Arrestin2 -0.05 0.169 -9999.0 0.0 -0.507 29.0 29.0 SMO -0.061 0.177 -9999.0 0.0 -0.503 37.0 37.0 AKT1 -0.005 0.086 -9999.0 0.0 -0.318 7.0 7.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.039 0.169 -9999.0 0.0 -0.568 38.0 38.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.06 0.175 -9999.0 0.0 -0.495 37.0 37.0 STIL -0.154 0.215 -9999.0 0.0 -0.47 89.0 89.0 DHH N/PTCH2 -0.019 0.129 -9999.0 0.0 -0.419 38.0 38.0 DHH N/PTCH1 -0.037 0.162 -9999.0 0.0 -0.502 26.0 26.0 PIK3CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.013 0.123 -9999.0 0.0 -0.569 19.0 19.0 PTHLH -0.111 0.365 -9999.0 0.0 -1.03 49.0 49.0 determination of left/right symmetry -0.06 0.175 -9999.0 0.0 -0.495 37.0 37.0 PIK3R1 0.014 0.029 -9999.0 0.0 -0.569 1.0 1.0 skeletal system development -0.109 0.36 -9999.0 0.0 -1.013 49.0 49.0 IHH N/Hhip -0.142 0.231 -9999.0 0.0 -0.44 144.0 144.0 DHH N/Hhip -0.111 0.206 -9999.0 0.0 -0.423 121.0 121.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.06 0.175 -9999.0 0.0 -0.495 37.0 37.0 pancreas development -0.139 0.255 -9999.0 0.0 -0.567 107.0 107.0 HHAT 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.022 0.021 -9999.0 0.0 -0.408 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.125 0.249 -9999.0 0.0 -0.568 98.0 98.0 somite specification -0.06 0.175 -9999.0 0.0 -0.495 37.0 37.0 SHH Np/Cholesterol/PTCH1 -0.123 0.192 -9999.0 0.0 -0.449 62.0 62.0 SHH Np/Cholesterol/PTCH2 -0.113 0.174 -9999.0 0.0 -0.321 163.0 163.0 SHH Np/Cholesterol/Megalin -0.157 0.199 -9999.0 0.0 -0.347 198.0 198.0 SHH -0.137 0.207 -9999.0 0.0 -0.409 150.0 150.0 catabolic process -0.032 0.158 -9999.0 0.0 -0.468 27.0 27.0 SMO/Vitamin D3 -0.119 0.201 -9999.0 0.0 -0.477 56.0 56.0 SHH Np/Cholesterol/Hhip -0.184 0.218 -9999.0 0.0 -0.375 212.0 212.0 LRP2 -0.094 0.21 -9999.0 0.0 -0.507 84.0 84.0 receptor-mediated endocytosis -0.15 0.211 -9999.0 0.0 -0.469 83.0 83.0 SHH Np/Cholesterol/BOC -0.128 0.182 -9999.0 0.0 -0.329 176.0 176.0 SHH Np/Cholesterol/CDO -0.143 0.184 -9999.0 0.0 -0.329 194.0 194.0 mesenchymal cell differentiation 0.183 0.216 0.373 212.0 -9999.0 0.0 212.0 mol:Vitamin D3 -0.121 0.194 -9999.0 0.0 -0.45 62.0 62.0 IHH N/PTCH2 -0.043 0.146 -9999.0 0.0 -0.345 71.0 71.0 CDON -0.066 0.203 -9999.0 0.0 -0.569 57.0 57.0 IHH N/PTCH1 -0.032 0.159 -9999.0 0.0 -0.473 27.0 27.0 Megalin/LRPAP1 -0.057 0.153 -9999.0 0.0 -0.355 85.0 85.0 PTCH2 -0.013 0.126 -9999.0 0.0 -0.569 20.0 20.0 SHH Np/Cholesterol -0.114 0.155 -9999.0 0.0 -0.317 150.0 150.0 PTCH1 -0.033 0.158 -9999.0 0.0 -0.47 27.0 27.0 HHIP -0.14 0.255 -9999.0 0.0 -0.568 107.0 107.0