Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.027 0.051 -9999.0 0.0 -0.242 14.0 14.0 epithelial cell differentiation -0.01 0.051 -9999.0 0.0 -0.279 14.0 14.0 CYFIP2 -0.0 0.095 -9999.0 0.0 -0.569 11.0 11.0 ENAH 0.06 0.055 -9999.0 0.0 -0.325 1.0 1.0 EGFR -0.008 0.111 -9999.0 0.0 -0.54 17.0 17.0 EPHA2 0.008 0.064 -9999.0 0.0 -0.569 5.0 5.0 MYO6 0.033 0.055 -9999.0 0.0 -0.259 14.0 14.0 CTNNB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.022 0.06 -9999.0 0.0 -0.338 11.0 11.0 AQP5 -0.013 0.045 -9999.0 0.0 -0.347 1.0 1.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.033 0.054 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.017 0.086 -9999.0 0.0 -0.284 18.0 18.0 EGF -0.018 0.125 -9999.0 0.0 -0.507 25.0 25.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.096 0.197 -9999.0 0.0 -0.486 80.0 80.0 cortical microtubule organization -0.01 0.051 -9999.0 0.0 -0.279 14.0 14.0 GO:0000145 0.031 0.052 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.058 -9999.0 0.0 -0.281 14.0 14.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.013 0.051 -9999.0 0.0 -0.454 1.0 1.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.03 0.057 -9999.0 0.0 -0.299 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.045 0.055 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.032 0.057 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.008 0.044 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.004 0.106 -9999.0 0.0 -0.569 14.0 14.0 EGFR/EGFR/EGF/EGF -0.031 0.083 -9999.0 0.0 -0.501 3.0 3.0 RhoA/GDP -0.009 0.047 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.039 0.055 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.011 0.05 -9999.0 0.0 -0.568 3.0 3.0 GIT1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.011 0.05 -9999.0 0.0 -0.569 3.0 3.0 IGF1 -0.245 0.291 -9999.0 0.0 -0.569 182.0 182.0 DIAPH1 -0.014 0.094 -9999.0 0.0 -0.58 11.0 11.0 Wnt receptor signaling pathway 0.01 0.051 0.279 14.0 -9999.0 0.0 14.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.013 0.051 -9999.0 0.0 -0.455 1.0 1.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.039 0.056 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.004 0.077 -9999.0 0.0 -0.507 9.0 9.0 LPP 0.04 0.055 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.016 0.062 -9999.0 0.0 -0.526 1.0 1.0 SEC6/SEC8 -0.007 0.039 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.017 0.088 -9999.0 0.0 -0.288 18.0 18.0 HGF/MET -0.066 0.111 -9999.0 0.0 -0.488 2.0 2.0 HGF -0.118 0.244 -9999.0 0.0 -0.564 94.0 94.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.027 0.051 -9999.0 0.0 -0.244 14.0 14.0 actin cable formation 0.077 0.054 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.031 0.095 -9999.0 0.0 -0.523 9.0 9.0 KIFC3 0.033 0.055 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.033 0.055 -9999.0 0.0 -0.259 14.0 14.0 NCK1/GIT1 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.01 0.051 -9999.0 0.0 -0.279 14.0 14.0 EXOC4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.033 0.055 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.033 0.055 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.055 0.062 -9999.0 0.0 -0.391 1.0 1.0 adherens junction assembly 0.048 0.094 -9999.0 0.0 -0.499 9.0 9.0 IGF-1R heterotetramer/IGF1 -0.12 0.13 -9999.0 0.0 -0.527 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.013 0.036 -9999.0 0.0 -0.507 2.0 2.0 PLEKHA7 0.033 0.06 -9999.0 0.0 -0.28 14.0 14.0 mol:GTP 0.028 0.056 -9999.0 0.0 -0.297 5.0 5.0 establishment of epithelial cell apical/basal polarity 0.061 0.05 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.027 0.051 -9999.0 0.0 -0.242 14.0 14.0 regulation of cell-cell adhesion 0.039 0.055 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.027 0.051 -9999.0 0.0 -0.244 14.0 14.0