E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.002 0.1 -9999.0 0.0 -0.41 17.0 17.0 KLHL20 0.009 0.086 0.195 3.0 -0.202 33.0 36.0 CYFIP2 0.014 0.077 -9999.0 0.0 -0.467 10.0 10.0 Rac1/GDP 0.026 0.091 0.268 10.0 -0.258 12.0 22.0 ENAH 0.003 0.101 -9999.0 0.0 -0.405 18.0 18.0 AP1M1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.017 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.021 0.045 -9999.0 0.0 -0.141 28.0 28.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.073 -9999.0 0.0 -0.271 17.0 17.0 RAPGEF1 0.014 0.099 0.262 6.0 -0.367 16.0 22.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.009 0.105 -9999.0 0.0 -0.415 18.0 18.0 CRK 0.009 0.096 -9999.0 0.0 -0.394 16.0 16.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.068 -9999.0 0.0 -0.302 14.0 14.0 alphaE/beta7 Integrin 0.032 0.043 -9999.0 0.0 -0.331 5.0 5.0 IQGAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.046 0.018 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.004 0.098 -9999.0 0.0 -0.409 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.0 0.029 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.046 0.031 -9999.0 0.0 -0.257 3.0 3.0 PI3K 0.004 0.038 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.024 0.074 -9999.0 0.0 -0.355 14.0 14.0 TIAM1 0.023 0.043 -9999.0 0.0 -0.467 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.047 0.058 -9999.0 0.0 -0.243 13.0 13.0 AKT1 0.016 0.039 0.147 1.0 -9999.0 0.0 1.0 PIK3R1 0.025 0.025 -9999.0 0.0 -0.467 1.0 1.0 CDH1 0.01 0.087 -9999.0 0.0 -0.467 13.0 13.0 RhoA/GDP 0.027 0.092 0.276 10.0 -0.26 12.0 22.0 actin cytoskeleton organization 0.01 0.067 0.162 7.0 -0.159 14.0 21.0 CDC42/GDP 0.028 0.094 0.273 11.0 -0.26 12.0 23.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.01 0.051 -9999.0 0.0 -0.244 14.0 14.0 ITGB7 0.021 0.055 -9999.0 0.0 -0.467 5.0 5.0 RAC1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.051 0.062 -9999.0 0.0 -0.259 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.053 -9999.0 0.0 -0.242 13.0 13.0 mol:GDP 0.014 0.1 0.279 11.0 -0.293 14.0 25.0 CDC42/GTP/IQGAP1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.024 0.035 -9999.0 0.0 -0.467 2.0 2.0 p120 catenin/RhoA/GDP 0.031 0.092 0.282 7.0 -0.266 12.0 19.0 RAC1/GTP/IQGAP1 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.013 0.055 0.15 13.0 -0.179 7.0 20.0 NME1 0.027 0.011 0.212 1.0 -9999.0 0.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.006 0.097 -9999.0 0.0 -0.41 17.0 17.0 regulation of cell-cell adhesion 0.01 0.039 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.006 0.037 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.027 0.062 0.278 2.0 -9999.0 0.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.052 0.078 -9999.0 0.0 -0.269 18.0 18.0 CCND1 0.013 0.064 0.164 12.0 -0.222 7.0 19.0 VAV2 -0.028 0.2 -9999.0 0.0 -0.557 38.0 38.0 RAP1/GDP 0.031 0.077 0.279 6.0 -9999.0 0.0 6.0 adherens junction assembly 0.006 0.094 -9999.0 0.0 -0.398 17.0 17.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.04 0.074 -9999.0 0.0 -0.258 18.0 18.0 E-cadherin/beta catenin 0.002 0.062 -9999.0 0.0 -0.319 14.0 14.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.002 0.1 -9999.0 0.0 -0.405 18.0 18.0 PIK3CA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.039 0.102 -9999.0 0.0 -0.317 35.0 35.0 E-cadherin/beta catenin/alpha catenin 0.039 0.062 -9999.0 0.0 -0.284 13.0 13.0 ITGAE 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.002 0.105 -9999.0 0.0 -0.424 18.0 18.0