Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.002 0.118 0.352 40.0 -9999.0 0.0 40.0 KIRREL -0.022 0.151 -9999.0 0.0 -0.477 40.0 40.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.002 0.119 -9999.0 0.0 -0.352 40.0 40.0 PLCG1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.028 0.105 0.243 2.0 -0.265 40.0 42.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.0 0.078 -9999.0 0.0 -0.236 36.0 36.0 FYN -0.005 0.106 0.282 14.0 -0.257 41.0 55.0 mol:Ca2+ 0.026 0.099 0.235 2.0 -0.263 36.0 38.0 mol:DAG 0.027 0.1 0.239 2.0 -0.264 36.0 38.0 NPHS2 0.014 0.056 0.229 19.0 -9999.0 0.0 19.0 mol:IP3 0.027 0.1 0.239 2.0 -0.264 36.0 38.0 regulation of endocytosis 0.016 0.091 -9999.0 0.0 -0.24 40.0 40.0 Nephrin/NEPH1/podocin/Cholesterol 0.015 0.099 0.225 2.0 -0.263 40.0 42.0 establishment of cell polarity -0.002 0.118 -9999.0 0.0 -0.352 40.0 40.0 Nephrin/NEPH1/podocin/NCK1-2 0.039 0.1 -9999.0 0.0 -0.243 37.0 37.0 Nephrin/NEPH1/beta Arrestin2 0.017 0.093 -9999.0 0.0 -0.243 40.0 40.0 NPHS1 0.007 0.043 0.232 6.0 -9999.0 0.0 6.0 Nephrin/NEPH1/podocin 0.015 0.098 -9999.0 0.0 -0.258 41.0 41.0 TJP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.028 0.101 0.243 2.0 -0.265 36.0 38.0 CD2AP 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.029 0.103 0.243 2.0 -0.263 38.0 40.0 GRB2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.004 0.106 0.292 14.0 -0.252 40.0 54.0 cytoskeleton organization -0.008 0.088 0.209 7.0 -0.272 35.0 42.0 Nephrin/NEPH1 0.003 0.085 -9999.0 0.0 -0.244 40.0 40.0 Nephrin/NEPH1/ZO-1 0.014 0.101 -9999.0 0.0 -0.279 40.0 40.0