Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.028 0.204 -9999.0 0.0 -0.564 47.0 47.0 IHH 0.034 0.103 0.263 30.0 -0.265 17.0 47.0 SHH Np/Cholesterol/GAS1 -0.123 0.155 -9999.0 0.0 -0.282 186.0 186.0 LRPAP1 0.027 0.016 0.328 1.0 -9999.0 0.0 1.0 dorsoventral neural tube patterning 0.123 0.154 0.28 186.0 -9999.0 0.0 186.0 SMO/beta Arrestin2 -0.037 0.161 -9999.0 0.0 -0.441 33.0 33.0 SMO -0.053 0.162 -9999.0 0.0 -0.403 51.0 51.0 AKT1 -0.019 0.137 -9999.0 0.0 -0.557 15.0 15.0 ARRB2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.016 0.139 0.212 1.0 -0.467 35.0 36.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.052 0.16 -9999.0 0.0 -0.397 51.0 51.0 STIL -0.084 0.151 -9999.0 0.0 -0.308 68.0 68.0 DHH N/PTCH2 0.005 0.11 -9999.0 0.0 -0.344 36.0 36.0 DHH N/PTCH1 -0.007 0.131 -9999.0 0.0 -0.296 61.0 61.0 PIK3CA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.0 0.105 -9999.0 0.0 -0.467 19.0 19.0 PTHLH -0.069 0.312 -9999.0 0.0 -0.887 48.0 48.0 determination of left/right symmetry -0.052 0.16 -9999.0 0.0 -0.397 51.0 51.0 PIK3R1 0.025 0.025 -9999.0 0.0 -0.467 1.0 1.0 skeletal system development -0.068 0.308 -9999.0 0.0 -0.875 48.0 48.0 IHH N/Hhip -0.061 0.19 -9999.0 0.0 -0.379 100.0 100.0 DHH N/Hhip -0.068 0.174 -9999.0 0.0 -0.349 109.0 109.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.052 0.16 -9999.0 0.0 -0.397 51.0 51.0 pancreas development -0.098 0.208 0.212 1.0 -0.466 97.0 98.0 HHAT 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.035 0.023 -9999.0 0.0 -0.335 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.055 0.183 0.212 2.0 -0.467 66.0 68.0 somite specification -0.052 0.16 -9999.0 0.0 -0.397 51.0 51.0 SHH Np/Cholesterol/PTCH1 -0.088 0.151 -9999.0 0.0 -0.259 151.0 151.0 SHH Np/Cholesterol/PTCH2 -0.086 0.145 -9999.0 0.0 -0.268 151.0 151.0 SHH Np/Cholesterol/Megalin -0.065 0.151 0.234 2.0 -0.265 139.0 141.0 SHH -0.114 0.162 -9999.0 0.0 -0.336 140.0 140.0 catabolic process -0.006 0.124 -9999.0 0.0 -0.324 50.0 50.0 SMO/Vitamin D3 -0.092 0.169 -9999.0 0.0 -0.383 57.0 57.0 SHH Np/Cholesterol/Hhip -0.14 0.172 -9999.0 0.0 -0.303 197.0 197.0 LRP2 0.06 0.08 0.217 81.0 -9999.0 0.0 81.0 receptor-mediated endocytosis -0.098 0.166 -9999.0 0.0 -0.413 44.0 44.0 SHH Np/Cholesterol/BOC -0.092 0.146 -9999.0 0.0 -0.271 155.0 155.0 SHH Np/Cholesterol/CDO -0.107 0.15 -9999.0 0.0 -0.273 175.0 175.0 mesenchymal cell differentiation 0.139 0.171 0.301 197.0 -9999.0 0.0 197.0 mol:Vitamin D3 -0.084 0.156 -9999.0 0.0 -0.263 137.0 137.0 IHH N/PTCH2 0.019 0.11 0.214 1.0 -0.339 26.0 27.0 CDON -0.033 0.16 -9999.0 0.0 -0.467 48.0 48.0 IHH N/PTCH1 0.01 0.136 -9999.0 0.0 -0.325 51.0 51.0 Megalin/LRPAP1 0.063 0.058 0.242 4.0 -0.156 2.0 6.0 PTCH2 0.004 0.105 -9999.0 0.0 -0.467 19.0 19.0 SHH Np/Cholesterol -0.081 0.128 -9999.0 0.0 -0.256 141.0 141.0 PTCH1 -0.006 0.124 -9999.0 0.0 -0.325 50.0 50.0 HHIP -0.098 0.208 0.212 1.0 -0.467 97.0 98.0