Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.016 0.045 -9999.0 0.0 -0.222 13.0 13.0 epithelial cell differentiation 0.042 0.056 -9999.0 0.0 -0.241 13.0 13.0 CYFIP2 0.014 0.077 -9999.0 0.0 -0.467 10.0 10.0 ENAH 0.019 0.09 0.318 17.0 -0.294 1.0 18.0 EGFR 0.021 0.085 0.328 8.0 -0.467 9.0 17.0 EPHA2 0.021 0.055 -9999.0 0.0 -0.467 5.0 5.0 MYO6 0.017 0.063 0.271 2.0 -0.232 13.0 15.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.055 -9999.0 0.0 -0.283 10.0 10.0 AQP5 0.02 0.058 0.368 2.0 -9999.0 0.0 2.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.018 0.063 0.297 3.0 -0.229 12.0 15.0 regulation of calcium-dependent cell-cell adhesion 0.019 0.073 0.296 5.0 -0.231 17.0 22.0 EGF 0.034 0.047 0.212 24.0 -9999.0 0.0 24.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.077 0.191 -9999.0 0.0 -0.467 68.0 68.0 cortical microtubule organization 0.042 0.056 -9999.0 0.0 -0.241 13.0 13.0 GO:0000145 0.0 0.061 0.181 26.0 -0.219 12.0 38.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.047 0.058 -9999.0 0.0 -0.243 13.0 13.0 MLLT4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.017 0.042 -9999.0 0.0 -0.276 3.0 3.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.059 0.047 0.241 5.0 -0.259 4.0 9.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.009 0.055 0.27 2.0 -0.212 12.0 14.0 PVRL2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.018 0.065 0.355 2.0 -0.231 13.0 15.0 ARF6/GTP 0.064 0.048 -9999.0 0.0 -0.242 4.0 4.0 CDH1 0.01 0.087 -9999.0 0.0 -0.467 13.0 13.0 EGFR/EGFR/EGF/EGF 0.031 0.07 -9999.0 0.0 -0.24 21.0 21.0 RhoA/GDP 0.043 0.055 -9999.0 0.0 -0.23 13.0 13.0 actin cytoskeleton organization 0.009 0.058 0.257 2.0 -0.229 12.0 14.0 IGF-1R heterotetramer 0.025 0.035 -9999.0 0.0 -0.466 2.0 2.0 GIT1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.035 -9999.0 0.0 -0.467 2.0 2.0 IGF1 -0.188 0.245 -9999.0 0.0 -0.467 176.0 176.0 DIAPH1 0.004 0.151 -9999.0 0.0 -0.567 16.0 16.0 Wnt receptor signaling pathway -0.042 0.056 0.241 13.0 -9999.0 0.0 13.0 RHOA 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.017 0.042 -9999.0 0.0 -0.402 1.0 1.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.009 0.059 0.259 2.0 -0.234 12.0 14.0 EFNA1 0.031 0.039 0.299 8.0 -9999.0 0.0 8.0 LPP -0.005 0.058 0.267 2.0 -0.229 1.0 3.0 Ephrin A1/EPHA2 0.032 0.059 -9999.0 0.0 -0.24 15.0 15.0 SEC6/SEC8 0.005 0.037 -9999.0 0.0 -0.217 9.0 9.0 MGAT3 0.019 0.074 0.325 4.0 -0.234 17.0 21.0 HGF/MET -0.018 0.117 -9999.0 0.0 -0.227 93.0 93.0 HGF -0.076 0.205 0.212 7.0 -0.467 86.0 93.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.016 0.046 -9999.0 0.0 -0.223 13.0 13.0 actin cable formation 0.041 0.096 0.315 22.0 -0.248 1.0 23.0 KIAA1543 -0.002 0.063 0.262 2.0 -0.238 13.0 15.0 KIFC3 0.017 0.063 0.355 2.0 -0.232 13.0 15.0 NCK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.016 0.062 0.355 1.0 -0.232 13.0 14.0 NCK1/GIT1 0.037 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.042 0.056 -9999.0 0.0 -0.241 13.0 13.0 EXOC4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.017 0.062 0.355 2.0 -0.232 12.0 14.0 PIP5K1C 0.018 0.064 0.355 2.0 -0.232 12.0 14.0 LIMA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.023 0.099 0.337 18.0 -0.343 1.0 19.0 adherens junction assembly 0.005 0.077 0.294 4.0 -0.434 1.0 5.0 IGF-1R heterotetramer/IGF1 -0.079 0.138 -9999.0 0.0 -0.231 177.0 177.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.029 0.022 0.328 2.0 -9999.0 0.0 2.0 PLEKHA7 0.016 0.066 0.355 1.0 -0.249 13.0 14.0 mol:GTP 0.057 0.046 0.234 5.0 -0.258 4.0 9.0 establishment of epithelial cell apical/basal polarity 0.031 0.101 0.343 18.0 -9999.0 0.0 18.0 cortical actin cytoskeleton stabilization 0.016 0.045 -9999.0 0.0 -0.222 13.0 13.0 regulation of cell-cell adhesion 0.009 0.058 0.257 2.0 -0.229 12.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.016 0.046 -9999.0 0.0 -0.223 13.0 13.0