Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events regulated by Ret tyrosine kinase	90.0	7435.0	82.0	-0.239	0.031	1000.0	-1000.0	-0.041	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	88.0	6014.0	68.0	-0.679	0.351	1000.0	-1000.0	-0.042	-1000.0
Signaling mediated by p38-alpha and p38-beta	82.0	3618.0	44.0	-0.228	0.027	1000.0	-1000.0	-0.021	-1000.0
Endothelins	80.0	7767.0	96.0	-0.382	0.089	1000.0	-1000.0	-0.037	-1000.0
IGF1 pathway	80.0	4589.0	57.0	-0.195	0.05	1000.0	-1000.0	-0.024	-1000.0
Nongenotropic Androgen signaling	74.0	3861.0	52.0	-0.262	0.15	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by the Hedgehog family	68.0	3579.0	52.0	-0.14	0.139	1000.0	-1000.0	-0.019	-1000.0
IL4-mediated signaling events	66.0	6095.0	91.0	-0.714	0.508	1000.0	-1000.0	-0.045	-1000.0
Reelin signaling pathway	65.0	3648.0	56.0	-0.147	0.062	1000.0	-1000.0	-0.027	-1000.0
Aurora B signaling	62.0	4156.0	67.0	-0.315	0.239	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	61.0	4799.0	78.0	-0.279	0.101	1000.0	-1000.0	-0.041	-1000.0
Thromboxane A2 receptor signaling	59.0	6224.0	105.0	-0.221	0.049	1000.0	-1000.0	-0.032	-1000.0
p75(NTR)-mediated signaling	55.0	6876.0	125.0	-0.113	0.078	1000.0	-1000.0	-0.039	-1000.0
Fc-epsilon receptor I signaling in mast cells	50.0	4861.0	97.0	-0.132	0.029	1000.0	-1000.0	-0.042	-1000.0
Glypican 2 network	50.0	200.0	4.0	0.037	0.093	1000.0	-1000.0	0.013	-1000.0
TCGA08_retinoblastoma	50.0	402.0	8.0	-0.025	0.107	1000.0	-1000.0	-0.001	-1000.0
Plasma membrane estrogen receptor signaling	50.0	4353.0	86.0	-0.269	0.146	1000.0	-1000.0	-0.035	-1000.0
Ephrin A  reverse signaling	47.0	332.0	7.0	-0.057	0.011	1000.0	-1000.0	-0.002	-1000.0
TCR signaling in naïve CD8+ T cells	47.0	4448.0	93.0	-0.122	0.05	1000.0	-1000.0	-0.032	-1000.0
S1P4 pathway	46.0	1162.0	25.0	-0.125	0.046	1000.0	-1000.0	-0.013	-1000.0
Ras signaling in the CD4+ TCR pathway	46.0	790.0	17.0	-0.121	0.037	1000.0	-1000.0	-0.009	-1000.0
LPA receptor mediated events	45.0	4610.0	102.0	-0.237	0.068	1000.0	-1000.0	-0.064	-1000.0
IL23-mediated signaling events	45.0	2748.0	60.0	-0.467	0.037	1000.0	-1000.0	-0.021	-1000.0
S1P5 pathway	44.0	761.0	17.0	-0.125	0.078	1000.0	-1000.0	-0.005	-1000.0
Integrins in angiogenesis	44.0	3745.0	84.0	-0.232	0.101	1000.0	-1000.0	-0.03	-1000.0
Calcium signaling in the CD4+ TCR pathway	42.0	1310.0	31.0	-0.202	0.026	1000.0	-1000.0	-0.03	-1000.0
S1P1 pathway	41.0	1508.0	36.0	-0.301	0.026	1000.0	-1000.0	-0.018	-1000.0
Rapid glucocorticoid signaling	40.0	801.0	20.0	-0.174	0.059	1000.0	-1000.0	-0.002	-1000.0
BMP receptor signaling	39.0	3234.0	81.0	-0.259	0.071	1000.0	-1000.0	-0.027	-1000.0
IL6-mediated signaling events	39.0	2976.0	75.0	-0.202	0.062	1000.0	-1000.0	-0.031	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	38.0	1977.0	52.0	-0.247	0.038	1000.0	-1000.0	-0.024	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	38.0	4617.0	120.0	-0.236	0.167	1000.0	-1000.0	-0.033	-1000.0
PDGFR-alpha signaling pathway	37.0	1670.0	44.0	-0.298	0.039	1000.0	-1000.0	-0.031	-1000.0
amb2 Integrin signaling	37.0	3090.0	82.0	-0.289	0.068	1000.0	-1000.0	-0.021	-1000.0
JNK signaling in the CD4+ TCR pathway	36.0	612.0	17.0	-0.169	0.03	1000.0	-1000.0	-0.027	-1000.0
Glypican 1 network	36.0	1731.0	48.0	-0.19	0.048	1000.0	-1000.0	-0.015	-1000.0
S1P3 pathway	36.0	1532.0	42.0	-0.125	0.041	1000.0	-1000.0	-0.018	-1000.0
IL12-mediated signaling events	35.0	3096.0	87.0	-0.403	0.057	1000.0	-1000.0	-0.057	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	34.0	1840.0	54.0	-0.147	0.062	1000.0	-1000.0	-0.023	-1000.0
PLK1 signaling events	34.0	2904.0	85.0	-0.028	0.159	1000.0	-1000.0	-0.027	-1000.0
Glucocorticoid receptor regulatory network	34.0	3978.0	114.0	-0.524	0.156	1000.0	-1000.0	-0.047	-1000.0
LPA4-mediated signaling events	32.0	391.0	12.0	-0.131	0.008	1000.0	-1000.0	-0.02	-1000.0
HIF-1-alpha transcription factor network	32.0	2457.0	76.0	-0.124	0.069	1000.0	-1000.0	-0.039	-1000.0
Angiopoietin receptor Tie2-mediated signaling	32.0	2875.0	88.0	-0.17	0.051	1000.0	-1000.0	-0.05	-1000.0
Coregulation of Androgen receptor activity	31.0	2392.0	76.0	-0.18	0.108	1000.0	-1000.0	-0.015	-1000.0
Syndecan-1-mediated signaling events	31.0	1059.0	34.0	-0.076	0.13	1000.0	-1000.0	-0.022	-1000.0
BCR signaling pathway	30.0	3058.0	99.0	-0.105	0.037	1000.0	-1000.0	-0.042	-1000.0
Osteopontin-mediated events	29.0	1128.0	38.0	-0.125	0.104	1000.0	-1000.0	-0.026	-1000.0
Syndecan-2-mediated signaling events	29.0	2043.0	69.0	-0.041	0.056	1000.0	-1000.0	-0.027	-1000.0
Arf6 signaling events	29.0	1804.0	62.0	-0.173	0.059	1000.0	-1000.0	-0.031	-1000.0
Aurora C signaling	28.0	198.0	7.0	-0.0	0.107	1000.0	-1000.0	-0.01	-1000.0
Wnt signaling	27.0	195.0	7.0	-0.01	0.03	1000.0	-1000.0	-0.006	-1000.0
FOXM1 transcription factor network	27.0	1404.0	51.0	-0.183	0.111	1000.0	-1000.0	-0.055	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	26.0	886.0	34.0	-0.022	0.039	1000.0	-1000.0	-0.024	-1000.0
ErbB2/ErbB3 signaling events	25.0	1687.0	65.0	-0.177	0.039	1000.0	-1000.0	-0.039	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	25.0	2145.0	85.0	-0.226	0.039	1000.0	-1000.0	-0.045	-1000.0
FAS signaling pathway (CD95)	25.0	1177.0	47.0	-0.529	0.044	1000.0	-1000.0	-0.024	-1000.0
Visual signal transduction: Cones	24.0	937.0	38.0	-0.077	0.078	1000.0	-1000.0	-0.006	-1000.0
Presenilin action in Notch and Wnt signaling	23.0	1409.0	61.0	-0.125	0.111	1000.0	-1000.0	-0.045	-1000.0
Noncanonical Wnt signaling pathway	22.0	586.0	26.0	-0.072	0.03	1000.0	-1000.0	-0.03	-1000.0
Class IB PI3K non-lipid kinase events	21.0	63.0	3.0	-0.0	-1000.0	1000.0	-1000.0	-0.014	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	20.0	671.0	33.0	-0.217	0.106	1000.0	-1000.0	-0.023	-1000.0
Sphingosine 1-phosphate (S1P) pathway	19.0	549.0	28.0	-0.125	0.059	1000.0	-1000.0	-0.011	-1000.0
Aurora A signaling	19.0	1174.0	60.0	-0.214	0.16	1000.0	-1000.0	-0.013	-1000.0
Canonical Wnt signaling pathway	19.0	1004.0	51.0	-0.082	0.111	1000.0	-1000.0	-0.038	-1000.0
Syndecan-4-mediated signaling events	19.0	1332.0	67.0	-0.129	0.067	1000.0	-1000.0	-0.027	-1000.0
Visual signal transduction: Rods	19.0	1035.0	52.0	-0.077	0.105	1000.0	-1000.0	-0.012	-1000.0
Regulation of Androgen receptor activity	19.0	1370.0	70.0	-0.175	0.036	1000.0	-1000.0	-0.03	-1000.0
Hedgehog signaling events mediated by Gli proteins	18.0	1180.0	65.0	-0.125	0.065	1000.0	-1000.0	-0.029	-1000.0
Effects of Botulinum toxin	18.0	481.0	26.0	-0.01	0.056	1000.0	-1000.0	-0.001	-1000.0
Cellular roles of Anthrax toxin	17.0	673.0	39.0	-0.075	0.036	1000.0	-1000.0	-0.015	-1000.0
Ceramide signaling pathway	17.0	1293.0	76.0	-0.188	0.071	1000.0	-1000.0	-0.022	-1000.0
ceramide signaling pathway	17.0	843.0	49.0	-0.0	0.05	1000.0	-1000.0	-0.04	-1000.0
TCGA08_p53	17.0	125.0	7.0	-0.004	0.027	1000.0	-1000.0	-0.003	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	17.0	1273.0	74.0	-0.188	0.064	1000.0	-1000.0	-0.054	-1000.0
Ephrin B reverse signaling	16.0	799.0	48.0	-0.038	0.041	1000.0	-1000.0	-0.024	-1000.0
Insulin Pathway	16.0	1208.0	74.0	-0.194	0.066	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by PTP1B	15.0	1149.0	76.0	-0.112	0.042	1000.0	-1000.0	-0.031	-1000.0
Nectin adhesion pathway	15.0	1000.0	63.0	-0.034	0.056	1000.0	-1000.0	-0.036	-1000.0
EPHB forward signaling	14.0	1233.0	85.0	-0.013	0.069	1000.0	-1000.0	-0.044	-1000.0
Caspase cascade in apoptosis	13.0	964.0	74.0	-0.049	0.05	1000.0	-1000.0	-0.03	-1000.0
ErbB4 signaling events	13.0	902.0	69.0	-0.177	0.047	1000.0	-1000.0	-0.03	-1000.0
IL2 signaling events mediated by PI3K	13.0	775.0	58.0	-0.063	0.115	1000.0	-1000.0	-0.031	-1000.0
Regulation of p38-alpha and p38-beta	13.0	713.0	54.0	-0.102	0.06	1000.0	-1000.0	-0.04	-1000.0
IL27-mediated signaling events	13.0	709.0	51.0	-0.181	0.047	1000.0	-1000.0	-0.048	-1000.0
IL2 signaling events mediated by STAT5	13.0	296.0	22.0	-0.037	0.076	1000.0	-1000.0	-0.019	-1000.0
EGFR-dependent Endothelin signaling events	13.0	273.0	21.0	-0.037	0.074	1000.0	-1000.0	-0.032	-1000.0
PDGFR-beta signaling pathway	13.0	1310.0	97.0	-0.078	0.058	1000.0	-1000.0	-0.036	-1000.0
Regulation of nuclear SMAD2/3 signaling	12.0	1761.0	136.0	-0.154	0.092	1000.0	-1000.0	-0.029	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	12.0	1005.0	83.0	-0.247	0.044	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	11.0	758.0	68.0	-0.144	0.064	1000.0	-1000.0	-0.022	-1000.0
FOXA2 and FOXA3 transcription factor networks	10.0	479.0	46.0	-0.145	0.184	1000.0	-1000.0	-0.037	-1000.0
IFN-gamma pathway	10.0	703.0	68.0	-0.123	0.081	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class III	10.0	407.0	40.0	-0.177	0.051	1000.0	-1000.0	-0.032	-1000.0
IL1-mediated signaling events	10.0	649.0	62.0	-0.01	0.059	1000.0	-1000.0	-0.025	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	10.0	454.0	45.0	-0.007	0.065	1000.0	-1000.0	-0.037	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	47.0	5.0	0.013	0.027	1000.0	-1000.0	0.01	-1000.0
E-cadherin signaling in the nascent adherens junction	9.0	698.0	76.0	-0.039	0.052	1000.0	-1000.0	-0.045	-1000.0
Arf6 trafficking events	9.0	639.0	71.0	-0.292	0.049	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by PRL	9.0	306.0	34.0	-0.061	0.043	1000.0	-1000.0	-0.029	-1000.0
BARD1 signaling events	8.0	485.0	57.0	-0.049	0.093	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	8.0	476.0	55.0	-0.021	0.072	1000.0	-1000.0	-0.02	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	8.0	328.0	37.0	-0.014	0.052	1000.0	-1000.0	-0.024	-1000.0
TCGA08_rtk_signaling	8.0	213.0	26.0	-0.04	0.06	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling events	8.0	42.0	5.0	0.01	0.037	1000.0	-1000.0	0.014	-1000.0
mTOR signaling pathway	7.0	404.0	53.0	-0.029	0.037	1000.0	-1000.0	-0.029	-1000.0
Signaling mediated by p38-gamma and p38-delta	7.0	110.0	15.0	-0.012	0.026	1000.0	-1000.0	-0.023	-1000.0
Syndecan-3-mediated signaling events	7.0	257.0	35.0	-0.062	0.062	1000.0	-1000.0	-0.019	-1000.0
Class I PI3K signaling events	7.0	525.0	73.0	-0.023	0.049	1000.0	-1000.0	-0.027	-1000.0
Regulation of Telomerase	7.0	810.0	102.0	-0.123	0.083	1000.0	-1000.0	-0.051	-1000.0
Retinoic acid receptors-mediated signaling	6.0	393.0	58.0	-0.052	0.06	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling in keratinocytes	6.0	283.0	43.0	-0.029	0.041	1000.0	-1000.0	-0.02	-1000.0
Paxillin-dependent events mediated by a4b1	5.0	211.0	36.0	-0.043	0.045	1000.0	-1000.0	-0.025	-1000.0
Insulin-mediated glucose transport	4.0	150.0	32.0	-0.139	0.048	1000.0	-1000.0	-0.022	-1000.0
HIF-2-alpha transcription factor network	4.0	204.0	43.0	-0.115	0.118	1000.0	-1000.0	-0.048	-1000.0
VEGFR1 specific signals	4.0	248.0	56.0	-0.053	0.069	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class II	3.0	297.0	75.0	-0.054	0.061	1000.0	-1000.0	-0.019	-1000.0
PLK2 and PLK4 events	3.0	11.0	3.0	0.015	0.032	1000.0	-1000.0	-0.002	-1000.0
TRAIL signaling pathway	3.0	154.0	48.0	-0.017	0.06	1000.0	-1000.0	-0.022	-1000.0
FoxO family signaling	3.0	255.0	64.0	-0.018	0.114	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	431.0	125.0	-0.039	0.072	1000.0	-1000.0	-0.022	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	3.0	82.0	27.0	-0.0	0.066	1000.0	-1000.0	-0.022	-1000.0
Canonical NF-kappaB pathway	2.0	87.0	39.0	-0.0	0.068	1000.0	-1000.0	-0.015	-1000.0
Arf6 downstream pathway	2.0	126.0	43.0	-0.051	0.052	1000.0	-1000.0	-0.026	-1000.0
p38 MAPK signaling pathway	2.0	125.0	44.0	-0.004	0.06	1000.0	-1000.0	-0.015	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	29.0	23.0	0.005	0.05	1000.0	-1000.0	-0.012	-1000.0
Circadian rhythm pathway	1.0	30.0	22.0	-0.01	0.058	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class I	1.0	120.0	104.0	-0.051	0.066	1000.0	-1000.0	-0.025	-1000.0
Atypical NF-kappaB pathway	1.0	51.0	31.0	-0.0	0.035	1000.0	-1000.0	-0.012	-1000.0
Arf1 pathway	1.0	54.0	54.0	-0.0	0.048	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.072	1000.0	-1000.0	0.0	-1000.0
Total	3327	201074	7203	-17.2546830412	-990.472850157	131000	-131000	-3.38675187115	-131000