# GENE SYMBOL DESC LIST LOC S2N RES CORE_ENRICHMENT 1 ADCY5 ADCY5 ADCY5 243 0.567 0.0363 YES 2 ADCY4 ADCY4 ADCY4 321 0.514 0.0771 YES 3 PDE1B PDE1B PDE1B 340 0.506 0.12 YES 4 PDE1A PDE1A PDE1A 344 0.504 0.164 YES 5 ADCYAP1R1 ADCYAP1R1 ADCYAP1R1 676 0.384 0.18 YES 6 NTRK1 NTRK1 NTRK1 829 0.353 0.202 YES 7 NGF NGF NGF 906 0.339 0.228 YES 8 NR4A1 NR4A1 NR4A1 947 0.333 0.255 YES 9 SHC2 SHC2 SHC2 1102 0.311 0.273 YES 10 NTRK2 NTRK2 NTRK2 1237 0.291 0.292 YES 11 ADCYAP1 ADCYAP1 ADCYAP1 1379 0.274 0.308 YES 12 MAPK11 MAPK11 MAPK11 1587 0.256 0.319 YES 13 DUSP4 DUSP4 DUSP4 1884 0.229 0.323 YES 14 CAMK4 CAMK4 CAMK4 1961 0.223 0.338 YES 15 IRS2 IRS2 IRS2 1967 0.223 0.357 YES 16 PRKAR2B PRKAR2B PRKAR2B 2211 0.205 0.362 YES 17 FOXO1 FOXO1 FOXO1 2452 0.19 0.365 YES 18 DNM1 DNM1 DNM1 2520 0.186 0.378 YES 19 MEF2C MEF2C MEF2C 2543 0.184 0.393 YES 20 ADORA2A ADORA2A ADORA2A 2744 0.173 0.397 YES 21 PRKCA PRKCA PRKCA 3223 0.15 0.383 YES 22 DUSP6 DUSP6 DUSP6 3232 0.15 0.396 YES 23 RPS6KA2 RPS6KA2 RPS6KA2 3302 0.147 0.405 YES 24 ADCY1 ADCY1 ADCY1 3329 0.146 0.417 YES 25 MAPK12 MAPK12 MAPK12 3731 0.129 0.406 NO 26 IRS1 IRS1 IRS1 3985 0.119 0.402 NO 27 AKT3 AKT3 AKT3 4331 0.107 0.393 NO 28 PRKAR1B PRKAR1B PRKAR1B 4395 0.105 0.398 NO 29 ADCY2 ADCY2 ADCY2 4778 0.0939 0.386 NO 30 PRKCE PRKCE PRKCE 4825 0.0924 0.391 NO 31 ADCY6 ADCY6 ADCY6 4877 0.0913 0.396 NO 32 RPS6KA3 RPS6KA3 RPS6KA3 4935 0.0898 0.401 NO 33 FOXO4 FOXO4 FOXO4 4954 0.0893 0.408 NO 34 PIK3R1 PIK3R1 PIK3R1 4989 0.0883 0.414 NO 35 ADCY9 ADCY9 ADCY9 5385 0.0779 0.399 NO 36 RAPGEF1 RAPGEF1 RAPGEF1 5680 0.071 0.389 NO 37 ADCY7 ADCY7 ADCY7 5894 0.066 0.383 NO 38 PPP2R1B PPP2R1B PPP2R1B 5928 0.0653 0.387 NO 39 ADRBK1 ADRBK1 ADRBK1 6110 0.0616 0.382 NO 40 MAPK7 MAPK7 MAPK7 6119 0.0614 0.387 NO 41 MAP2K5 MAP2K5 MAP2K5 6193 0.0595 0.388 NO 42 RALGDS RALGDS RALGDS 6305 0.0573 0.387 NO 43 BAD BAD BAD 6535 0.0525 0.379 NO 44 CDKN1B CDKN1B CDKN1B 6564 0.052 0.382 NO 45 ADCY3 ADCY3 ADCY3 6610 0.0512 0.384 NO 46 PRKACB PRKACB PRKACB 6648 0.0504 0.387 NO 47 PTEN PTEN PTEN 6785 0.0479 0.383 NO 48 ITPR2 ITPR2 ITPR2 6817 0.0473 0.386 NO 49 RAP1A RAP1A RAP1A 6899 0.0456 0.385 NO 50 AKT2 AKT2 AKT2 7031 0.0434 0.382 NO 51 RALB RALB RALB 7061 0.0427 0.384 NO 52 CASP9 CASP9 CASP9 7300 0.0386 0.374 NO 53 CDKN1A CDKN1A CDKN1A 7366 0.0375 0.374 NO 54 TSC2 TSC2 TSC2 7401 0.0369 0.375 NO 55 MAPK3 MAPK3 MAPK3 7546 0.0347 0.37 NO 56 DUSP7 DUSP7 DUSP7 7753 0.0315 0.362 NO 57 MAP2K2 MAP2K2 MAP2K2 7776 0.0311 0.363 NO 58 AP2A2 AP2A2 AP2A2 7789 0.0309 0.365 NO 59 PLCG1 PLCG1 PLCG1 7820 0.0305 0.366 NO 60 SHC3 SHC3 SHC3 7939 0.0287 0.362 NO 61 RPS6KA5 RPS6KA5 RPS6KA5 8320 0.0235 0.344 NO 62 MEF2A MEF2A MEF2A 8528 0.0209 0.334 NO 63 AKT1 AKT1 AKT1 8539 0.0207 0.335 NO 64 CALM3 CALM3 CALM3 8542 0.0207 0.337 NO 65 THEM4 THEM4 THEM4 8642 0.0191 0.333 NO 66 SHC1 SHC1 SHC1 8717 0.0181 0.331 NO 67 DUSP3 DUSP3 DUSP3 8762 0.0175 0.33 NO 68 AP2A1 AP2A1 AP2A1 8819 0.0168 0.328 NO 69 FOXO3 FOXO3 FOXO3 8891 0.016 0.326 NO 70 RHOA RHOA RHOA 8904 0.0158 0.326 NO 71 PPP2CB PPP2CB PPP2CB 8995 0.0145 0.323 NO 72 DNM2 DNM2 DNM2 9139 0.0127 0.316 NO 73 AKT1S1 AKT1S1 AKT1S1 9191 0.012 0.314 NO 74 PRKCD PRKCD PRKCD 9308 0.0106 0.309 NO 75 ATF1 ATF1 ATF1 9332 0.0103 0.308 NO 76 PDPK1 PDPK1 PDPK1 9426 0.00922 0.304 NO 77 MLST8 MLST8 MLST8 9755 0.00513 0.286 NO 78 RPS6KB2 RPS6KB2 RPS6KB2 9870 0.00341 0.28 NO 79 PIK3R2 PIK3R2 PIK3R2 9981 0.00207 0.275 NO 80 RICTOR RICTOR RICTOR 10067 0.00114 0.27 NO 81 MAPKAPK3 MAPKAPK3 MAPKAPK3 10148 2.17e-05 0.266 NO 82 FRS2 FRS2 FRS2 10440 -0.0032 0.25 NO 83 CREB1 CREB1 CREB1 10607 -0.00503 0.241 NO 84 PPP2R1A PPP2R1A PPP2R1A 10629 -0.00532 0.24 NO 85 CALM1 CALM1 CALM1 10674 -0.00589 0.238 NO 86 MAP2K1 MAP2K1 MAP2K1 10791 -0.00717 0.233 NO 87 RPS6KA1 RPS6KA1 RPS6KA1 10810 -0.00734 0.232 NO 88 PRKACA PRKACA PRKACA 10883 -0.00808 0.229 NO 89 MAPKAP1 MAPKAP1 MAPKAP1 10933 -0.00858 0.227 NO 90 MAPKAPK2 MAPKAPK2 MAPKAPK2 11065 -0.0102 0.221 NO 91 KRAS KRAS KRAS 11114 -0.0107 0.219 NO 92 STAT3 STAT3 STAT3 11374 -0.0135 0.206 NO 93 PRKAR1A PRKAR1A PRKAR1A 11430 -0.0143 0.204 NO 94 MAPK14 MAPK14 MAPK14 11533 -0.0154 0.2 NO 95 HRAS HRAS HRAS 11537 -0.0154 0.201 NO 96 AP2S1 AP2S1 AP2S1 11596 -0.016 0.199 NO 97 GRB2 GRB2 GRB2 11676 -0.0169 0.196 NO 98 CLTA CLTA CLTA 11679 -0.017 0.198 NO 99 AP2M1 AP2M1 AP2M1 11804 -0.0183 0.193 NO 100 KIDINS220 KIDINS220 KIDINS220 11806 -0.0184 0.194 NO 101 PPP2CA PPP2CA PPP2CA 12131 -0.0222 0.178 NO 102 SOS1 SOS1 SOS1 12156 -0.0224 0.179 NO 103 RIT1 RIT1 RIT1 12157 -0.0224 0.181 NO 104 RAF1 RAF1 RAF1 12185 -0.0226 0.181 NO 105 YWHAB YWHAB YWHAB 12414 -0.0251 0.171 NO 106 MDM2 MDM2 MDM2 12697 -0.0285 0.158 NO 107 CRK CRK CRK 13026 -0.0329 0.143 NO 108 NRAS NRAS NRAS 13068 -0.0334 0.143 NO 109 MAPK13 MAPK13 MAPK13 13089 -0.0336 0.145 NO 110 GSK3A GSK3A GSK3A 13140 -0.0342 0.145 NO 111 DNAL4 DNAL4 DNAL4 13159 -0.0344 0.148 NO 112 MAPK1 MAPK1 MAPK1 13399 -0.0376 0.138 NO 113 CHUK CHUK CHUK 13509 -0.0392 0.135 NO 114 RALA RALA RALA 13531 -0.0394 0.137 NO 115 ELK1 ELK1 ELK1 13556 -0.0397 0.14 NO 116 CALM2 CALM2 CALM2 13769 -0.0426 0.132 NO 117 AP2B1 AP2B1 AP2B1 14166 -0.0486 0.114 NO 118 PIK3CA PIK3CA PIK3CA 14366 -0.0516 0.108 NO 119 PRKCG PRKCG PRKCG 14402 -0.0522 0.11 NO 120 CLTC CLTC CLTC 14642 -0.056 0.102 NO 121 PIK3CB PIK3CB PIK3CB 15058 -0.0632 0.0846 NO 122 MTOR MTOR MTOR 15061 -0.0632 0.09 NO 123 PPP2R5D PPP2R5D PPP2R5D 15110 -0.0645 0.093 NO 124 ADCY8 ADCY8 ADCY8 15456 -0.0717 0.0803 NO 125 ITPR3 ITPR3 ITPR3 15462 -0.0718 0.0863 NO 126 PRKAR2A PRKAR2A PRKAR2A 15878 -0.082 0.0706 NO 127 SRC SRC SRC 15973 -0.0846 0.0728 NO 128 PHLPP1 PHLPP1 PHLPP1 16446 -0.0993 0.0555 NO 129 TRIB3 TRIB3 TRIB3 16546 -0.104 0.0592 NO 130 SH3GL2 SH3GL2 SH3GL2 16676 -0.11 0.0617 NO 131 BRAF BRAF BRAF 16924 -0.123 0.0588 NO 132 CDK1 CDK1 CDK1 17603 -0.179 0.0371 NO