E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.007 0.15 -9999.0 0.0 -0.53 37.0 37.0 KLHL20 -0.014 0.049 -9999.0 0.0 -0.22 8.0 8.0 CYFIP2 -0.002 0.051 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.046 0.1 -9999.0 0.0 -0.335 8.0 8.0 ENAH 0.01 0.149 -9999.0 0.0 -0.527 37.0 37.0 AP1M1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.016 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.01 0.065 -9999.0 0.0 -0.722 4.0 4.0 CDC42/GTP -0.019 0.064 -9999.0 0.0 -0.448 1.0 1.0 ABI1/Sra1/Nap1 -0.011 0.032 -9999.0 0.0 -0.18 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.028 0.106 -9999.0 0.0 -0.412 37.0 37.0 RAPGEF1 0.03 0.131 -9999.0 0.0 -0.439 37.0 37.0 CTNND1 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.142 -9999.0 0.0 -0.551 37.0 37.0 CRK 0.02 0.141 -9999.0 0.0 -0.486 37.0 37.0 E-cadherin/gamma catenin/alpha catenin -0.028 0.114 -9999.0 0.0 -0.458 34.0 34.0 alphaE/beta7 Integrin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.007 0.058 -9999.0 0.0 -0.421 10.0 10.0 DLG1 0.01 0.149 -9999.0 0.0 -0.527 37.0 37.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.064 -9999.0 0.0 -0.314 3.0 3.0 MLLT4 0.002 0.101 -9999.0 0.0 -0.722 10.0 10.0 ARF6/GTP/NME1/Tiam1 0.003 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.038 0.083 -9999.0 0.0 -0.425 3.0 3.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.036 0.133 -9999.0 0.0 -0.539 34.0 34.0 TIAM1 0.015 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.026 0.101 -9999.0 0.0 -0.39 37.0 37.0 AKT1 -0.02 0.048 -9999.0 0.0 -0.221 3.0 3.0 PIK3R1 -0.055 0.219 -9999.0 0.0 -0.722 51.0 51.0 CDH1 -0.032 0.179 -9999.0 0.0 -0.722 33.0 33.0 RhoA/GDP 0.046 0.1 -9999.0 0.0 -0.332 8.0 8.0 actin cytoskeleton organization -0.007 0.039 -9999.0 0.0 -0.178 4.0 4.0 CDC42/GDP 0.046 0.1 -9999.0 0.0 -0.332 8.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.01 0.083 -9999.0 0.0 -0.304 34.0 34.0 ITGB7 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.028 0.106 -9999.0 0.0 -0.412 37.0 37.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.027 0.103 -9999.0 0.0 -0.4 37.0 37.0 mol:GDP 0.039 0.115 -9999.0 0.0 -0.365 37.0 37.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.014 0.035 -9999.0 0.0 -0.722 1.0 1.0 p120 catenin/RhoA/GDP -0.023 0.081 -9999.0 0.0 -0.414 2.0 2.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 -0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.018 0.059 -9999.0 0.0 -0.216 17.0 17.0 NME1 0.011 0.029 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.009 0.153 -9999.0 0.0 -0.537 37.0 37.0 regulation of cell-cell adhesion -0.017 0.056 -9999.0 0.0 -0.383 1.0 1.0 WASF2 -0.004 0.017 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.021 0.075 -9999.0 0.0 -0.528 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.023 0.095 -9999.0 0.0 -0.379 34.0 34.0 CCND1 0.019 0.072 -9999.0 0.0 -0.271 17.0 17.0 VAV2 0.024 0.137 -9999.0 0.0 -0.468 37.0 37.0 RAP1/GDP -0.015 0.081 -9999.0 0.0 -0.515 1.0 1.0 adherens junction assembly 0.01 0.148 -9999.0 0.0 -0.512 38.0 38.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.024 0.093 -9999.0 0.0 -0.418 1.0 1.0 E-cadherin/beta catenin -0.029 0.109 -9999.0 0.0 -0.45 33.0 33.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.003 0.148 -9999.0 0.0 -0.527 37.0 37.0 PIK3CA 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.025 0.077 -9999.0 0.0 -0.348 11.0 11.0 E-cadherin/beta catenin/alpha catenin -0.031 0.118 -9999.0 0.0 -0.46 37.0 37.0 ITGAE 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.145 -9999.0 0.0 -0.565 37.0 37.0