Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q PTEN 15 (8%) 179 0.073959 0.308 0.74682 0.894 0.68741 0.836 0.59146 0.783 0.03341 0.213 0.22689 0.528 0.18447 0.496 0.19307 0.496 0.38658 0.661 0.090599 0.342 HLA-B 11 (6%) 183 0.56856 0.758 0.39648 0.672 0.90773 1 0.3282 0.611 0.45203 0.695 0.090469 0.342 0.01772 0.157 0.13572 0.445 0.0073699 0.109 0.03526 0.213 HLA-A 16 (8%) 178 0.60345 0.784 0.01036 0.109 0.32929 0.611 0.01805 0.157 0.0051799 0.109 0.065709 0.292 0.12625 0.432 0.0075399 0.109 0.21747 0.516 0.465 0.695 KRAS 11 (6%) 183 0.01005 0.109 0.00029 0.029 1 1 0.21784 0.516 0.0061299 0.109 0.00146 0.0584 0.00331 0.109 0.00073999 0.037 0.0099399 0.109 7.9999e-05 0.016 MLL2 22 (11%) 172 0.4343 0.695 0.60239 0.784 0.36832 0.641 0.23831 0.542 0.51965 0.737 0.077969 0.318 0.71546 0.862 0.3138 0.611 0.68979 0.836 0.86309 0.975 FBXW7 19 (10%) 175 0.55536 0.753 0.91066 1 0.84866 0.97 0.97138 1 0.28609 0.611 0.67735 0.836 0.18131 0.496 0.45471 0.695 0.42035 0.695 0.50352 0.724 EP300 21 (11%) 173 0.12076 0.431 0.20068 0.502 0.18209 0.496 0.03926 0.224 0.14785 0.462 0.072659 0.308 0.30048 0.611 0.0095999 0.109 1 1 0.29562 0.611 MAPK1 9 (5%) 185 0.0403 0.224 0.1436 0.462 0.33502 0.614 0.97591 1 0.093439 0.346 0.053939 0.263 0.04576 0.241 0.081959 0.328 0.03624 0.213 0.33004 0.611 MLL3 29 (15%) 165 0.15008 0.462 0.053889 0.263 0.49454 0.719 0.02094 0.168 0.0351 0.213 0.02233 0.172 0.072449 0.308 0.83723 0.97 0.32032 0.611 0.98957 1 ARID1A 14 (7%) 180 0.01142 0.114 0.057319 0.267 0.85349 0.97 0.12455 0.432 0.2052 0.502 0.00071999 0.037 0.13217 0.441 0.00461 0.109 0.23122 0.532 0.0093499 0.109 NFE2L2 12 (6%) 182 0.80813 0.951 0.0307 0.213 0.49606 0.719 0.04862 0.249 0.53709 0.749 0.04564 0.241 0.02465 0.183 0.01886 0.157 0.03302 0.213 0.55557 0.753 PIK3CA 53 (27%) 141 0.060949 0.277 0.45493 0.695 0.64048 0.806 0.29699 0.611 0.21924 0.516 0.00398 0.109 0.2896 0.611 0.34451 0.618 0.19587 0.496 0.055189 0.263 CASP8 9 (5%) 185 0.41199 0.692 0.52438 0.739 0.6182 0.798 0.16909 0.496 0.19521 0.496 0.46296 0.695 1 1 0.45122 0.695 0.31749 0.611 0.78418 0.928 FAT2 11 (6%) 183 0.84322 0.97 0.19527 0.496 1 1 0.62226 0.798 0.34911 0.618 0.48272 0.71 0.53917 0.749 0.75947 0.904 0.42418 0.695 0.33748 0.614 ZNF750 9 (5%) 185 0.1867 0.496 1 1 1 1 0.31921 0.611 0.55867 0.753 0.30349 0.611 0.28843 0.611 0.096289 0.35 0.31816 0.611 0.35134 0.618 C12ORF43 4 (2%) 190 0.85128 0.97 0.67683 0.836 NA NA NA NA 0.91222 1 0.45582 0.695 0.38562 0.661 0.20571 0.502 0.51741 0.737 0.56075 0.753 C3ORF70 4 (2%) 190 0.92106 1 0.088369 0.342 0.46879 0.695 0.17857 0.496 0.65645 0.821 0.12742 0.432 0.01476 0.141 0.29821 0.611 0.0081599 0.109 0.0085999 0.109 BAP1 4 (2%) 190 0.1675 0.496 0.4534 0.695 NA NA NA NA 0.44049 0.695 0.45645 0.695 0.68308 0.836 0.35226 0.618 0.55325 0.753 0.6285 0.801 USP28 4 (2%) 190 0.63633 0.805 0.25102 0.564 0.18174 0.496 0.90927 1 0.6031 0.784 1 1 0.4667 0.695 0.93707 1 0.32357 0.611 0.27445 0.61 IFNGR1 6 (3%) 188 0.14695 0.462 1 1 0.46929 0.695 0.9106 1 0.84592 0.97 1 1 0.32491 0.611 0.03333 0.213 0.19223 0.496 0.17421 0.496