E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.081 0.104 0.285 5.0 -0.274 6.0 11.0 KLHL20 0.041 0.052 0.161 11.0 -9999.0 0.0 11.0 CYFIP2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.066 0.08 0.234 24.0 -9999.0 0.0 24.0 ENAH 0.083 0.117 0.289 13.0 -0.279 9.0 22.0 AP1M1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.022 0.037 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.006 0.016 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.155 0.088 0.211 208.0 -9999.0 0.0 208.0 RAPGEF1 0.066 0.11 0.263 22.0 -0.258 10.0 32.0 CTNND1 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.097 0.12 0.262 1.0 -0.283 10.0 11.0 CRK 0.07 0.112 0.277 19.0 -0.271 10.0 29.0 E-cadherin/gamma catenin/alpha catenin 0.17 0.075 0.208 233.0 -9999.0 0.0 233.0 alphaE/beta7 Integrin 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.036 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.124 0.138 0.293 77.0 -0.281 7.0 84.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.0 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.019 -9999.0 0.0 -0.156 2.0 2.0 PI3K 0.004 0.023 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.185 0.071 0.216 246.0 -9999.0 0.0 246.0 TIAM1 0.018 0.026 -9999.0 0.0 -0.29 2.0 2.0 E-cadherin(dimer)/Ca2+ 0.152 0.078 0.196 218.0 -9999.0 0.0 218.0 AKT1 0.007 0.026 0.099 15.0 -9999.0 0.0 15.0 PIK3R1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.255 0.097 0.294 251.0 -9999.0 0.0 251.0 RhoA/GDP 0.072 0.071 0.237 23.0 -9999.0 0.0 23.0 actin cytoskeleton organization 0.036 0.044 0.14 14.0 -9999.0 0.0 14.0 CDC42/GDP 0.065 0.08 0.237 23.0 -9999.0 0.0 23.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.076 0.036 0.14 2.0 -9999.0 0.0 2.0 ITGB7 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.163 0.083 0.211 218.0 -9999.0 0.0 218.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.141 0.073 0.183 219.0 -9999.0 0.0 219.0 mol:GDP 0.062 0.083 0.242 24.0 -9999.0 0.0 24.0 CDC42/GTP/IQGAP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.073 0.079 0.241 22.0 -9999.0 0.0 22.0 RAC1/GTP/IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.03 0.036 0.156 7.0 -9999.0 0.0 7.0 NME1 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.075 0.111 0.274 2.0 -0.28 10.0 12.0 regulation of cell-cell adhesion 0.014 0.029 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.015 0.023 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.042 0.057 0.193 19.0 -9999.0 0.0 19.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.158 0.085 0.209 210.0 -9999.0 0.0 210.0 CCND1 0.033 0.037 0.155 5.0 -9999.0 0.0 5.0 VAV2 0.097 0.116 0.313 11.0 -9999.0 0.0 11.0 RAP1/GDP 0.057 0.066 0.223 21.0 -9999.0 0.0 21.0 adherens junction assembly 0.075 0.109 0.271 2.0 -0.273 10.0 12.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.141 0.082 0.193 201.0 -9999.0 0.0 201.0 E-cadherin/beta catenin 0.106 0.049 0.131 217.0 -9999.0 0.0 217.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.085 0.121 0.29 18.0 -0.28 10.0 28.0 PIK3CA 0.013 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.008 0.03 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin 0.16 0.083 0.208 219.0 -9999.0 0.0 219.0 ITGAE 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.096 0.122 -9999.0 0.0 -0.288 10.0 10.0