Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.011 0.064 0.207 20.0 -0.213 3.0 23.0 KIRREL 0.018 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.011 0.064 0.214 3.0 -0.207 20.0 23.0 PLCG1 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.029 0.056 0.202 3.0 -0.161 18.0 21.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.004 0.047 -9999.0 0.0 -0.193 15.0 15.0 FYN -0.002 0.084 0.212 30.0 -0.157 16.0 46.0 mol:Ca2+ 0.029 0.052 0.195 2.0 -0.161 16.0 18.0 mol:DAG 0.029 0.053 0.198 2.0 -0.162 16.0 18.0 NPHS2 -0.015 0.019 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.029 0.053 0.198 2.0 -0.162 16.0 18.0 regulation of endocytosis 0.019 0.053 0.184 3.0 -0.151 17.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.019 0.052 0.188 3.0 -0.151 20.0 23.0 establishment of cell polarity 0.011 0.064 0.213 3.0 -0.207 20.0 23.0 Nephrin/NEPH1/podocin/NCK1-2 0.029 0.054 -9999.0 0.0 -0.153 14.0 14.0 Nephrin/NEPH1/beta Arrestin2 0.021 0.055 0.191 3.0 -0.152 17.0 20.0 NPHS1 0.007 0.05 0.296 6.0 -9999.0 0.0 6.0 Nephrin/NEPH1/podocin 0.018 0.053 0.19 3.0 -0.143 25.0 28.0 TJP1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.015 0.009 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.03 0.053 0.202 2.0 -0.162 16.0 18.0 CD2AP 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.029 0.057 0.202 3.0 -0.162 18.0 21.0 GRB2 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.006 0.077 0.211 24.0 -0.148 16.0 40.0 cytoskeleton organization -0.016 0.054 0.183 8.0 -0.196 14.0 22.0 Nephrin/NEPH1 0.012 0.045 0.175 3.0 -0.136 20.0 23.0 Nephrin/NEPH1/ZO-1 0.021 0.057 0.2 3.0 -0.171 18.0 21.0