Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.047 0.088 -9999.0 0.0 -0.404 6.0 6.0 IHH 0.016 0.04 0.299 4.0 -0.13 5.0 9.0 SHH Np/Cholesterol/GAS1 -0.072 0.073 0.139 4.0 -0.155 119.0 123.0 LRPAP1 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.072 0.072 0.155 119.0 -0.137 4.0 123.0 SMO/beta Arrestin2 -0.089 0.161 -9999.0 0.0 -0.33 69.0 69.0 SMO -0.09 0.154 -9999.0 0.0 -0.337 62.0 62.0 AKT1 -0.04 0.109 -9999.0 0.0 -0.479 10.0 10.0 ARRB2 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.044 0.122 -9999.0 0.0 -0.29 57.0 57.0 ADRBK1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.093 0.156 -9999.0 0.0 -0.336 65.0 65.0 STIL -0.04 0.083 0.172 11.0 -0.231 6.0 17.0 DHH N/PTCH2 0.013 0.06 -9999.0 0.0 -0.204 21.0 21.0 DHH N/PTCH1 -0.036 0.093 -9999.0 0.0 -0.189 71.0 71.0 PIK3CA 0.013 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.017 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.072 0.14 -9999.0 0.0 -0.546 6.0 6.0 determination of left/right symmetry -0.093 0.156 -9999.0 0.0 -0.336 65.0 65.0 PIK3R1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.072 0.139 -9999.0 0.0 -0.541 6.0 6.0 IHH N/Hhip -0.027 0.102 0.198 5.0 -0.195 71.0 76.0 DHH N/Hhip 0.024 0.037 0.213 1.0 -0.2 7.0 8.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.093 0.156 -9999.0 0.0 -0.336 65.0 65.0 pancreas development 0.003 0.052 0.294 1.0 -0.29 7.0 8.0 HHAT 0.018 0.019 -9999.0 0.0 -0.29 1.0 1.0 PI3K 0.019 0.015 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.118 0.154 -9999.0 0.0 -0.29 130.0 130.0 somite specification -0.093 0.156 -9999.0 0.0 -0.336 65.0 65.0 SHH Np/Cholesterol/PTCH1 -0.047 0.073 0.209 3.0 -0.232 7.0 10.0 SHH Np/Cholesterol/PTCH2 -0.024 0.045 0.122 8.0 -0.155 22.0 30.0 SHH Np/Cholesterol/Megalin -0.01 0.04 0.157 13.0 -0.156 1.0 14.0 SHH -0.012 0.039 0.181 9.0 -0.204 1.0 10.0 catabolic process -0.05 0.097 -9999.0 0.0 -0.21 71.0 71.0 SMO/Vitamin D3 -0.064 0.112 0.339 1.0 -0.251 61.0 62.0 SHH Np/Cholesterol/Hhip -0.016 0.035 0.128 9.0 -0.154 7.0 16.0 LRP2 0.018 0.039 0.294 5.0 -9999.0 0.0 5.0 receptor-mediated endocytosis -0.064 0.107 0.289 1.0 -0.282 21.0 22.0 SHH Np/Cholesterol/BOC -0.037 0.062 0.127 6.0 -0.157 53.0 59.0 SHH Np/Cholesterol/CDO -0.019 0.042 0.122 8.0 -0.155 17.0 25.0 mesenchymal cell differentiation 0.016 0.035 0.153 7.0 -0.127 9.0 16.0 mol:Vitamin D3 -0.037 0.083 0.189 11.0 -0.232 7.0 18.0 IHH N/PTCH2 -0.038 0.109 0.192 4.0 -0.201 84.0 88.0 CDON -0.001 0.072 -9999.0 0.0 -0.29 17.0 17.0 IHH N/PTCH1 -0.036 0.103 -9999.0 0.0 -0.212 71.0 71.0 Megalin/LRPAP1 0.03 0.027 0.216 5.0 -9999.0 0.0 5.0 PTCH2 -0.004 0.082 -9999.0 0.0 -0.29 22.0 22.0 SHH Np/Cholesterol -0.01 0.015 -9999.0 0.0 -0.151 1.0 1.0 PTCH1 -0.05 0.097 -9999.0 0.0 -0.211 71.0 71.0 HHIP 0.003 0.052 0.294 1.0 -0.29 7.0 8.0