Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.071 0.048 0.151 5.0 -0.165 1.0 6.0 epithelial cell differentiation 0.139 0.071 0.18 218.0 -9999.0 0.0 218.0 CYFIP2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.029 0.071 0.153 64.0 -9999.0 0.0 64.0 EGFR 0.018 0.026 -9999.0 0.0 -0.29 2.0 2.0 EPHA2 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.037 0.03 0.18 4.0 -9999.0 0.0 4.0 CTNNB1 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.038 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.014 0.124 0.22 9.0 -0.356 24.0 33.0 CTNND1 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.036 0.029 0.178 4.0 -9999.0 0.0 4.0 regulation of calcium-dependent cell-cell adhesion 0.034 0.032 0.167 2.0 -9999.0 0.0 2.0 EGF 0.003 0.066 -9999.0 0.0 -0.29 14.0 14.0 NCKAP1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.079 0.078 0.217 21.0 -9999.0 0.0 21.0 cortical microtubule organization 0.139 0.071 0.18 218.0 -9999.0 0.0 218.0 GO:0000145 0.023 0.025 0.164 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.152 0.078 0.196 218.0 -9999.0 0.0 218.0 MLLT4 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.003 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.036 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.015 0.02 0.157 1.0 -9999.0 0.0 1.0 PVRL2 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.036 0.03 0.18 4.0 -9999.0 0.0 4.0 ARF6/GTP 0.037 0.029 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.255 0.097 0.294 251.0 -9999.0 0.0 251.0 EGFR/EGFR/EGF/EGF 0.085 0.069 0.211 2.0 -0.134 4.0 6.0 RhoA/GDP 0.121 0.062 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.027 0.028 0.167 4.0 -9999.0 0.0 4.0 IGF-1R heterotetramer 0.018 0.026 -9999.0 0.0 -0.29 2.0 2.0 GIT1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.018 0.026 -9999.0 0.0 -0.29 2.0 2.0 IGF1 -0.079 0.145 -9999.0 0.0 -0.29 93.0 93.0 DIAPH1 -0.006 0.134 -9999.0 0.0 -0.527 9.0 9.0 Wnt receptor signaling pathway -0.139 0.071 -9999.0 0.0 -0.18 218.0 218.0 RHOA 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.003 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.028 0.028 0.168 4.0 -9999.0 0.0 4.0 EFNA1 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.014 0.021 0.155 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 0.089 0.055 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.014 0.023 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.034 0.032 0.169 2.0 -9999.0 0.0 2.0 HGF/MET 0.072 0.081 0.234 1.0 -0.145 3.0 4.0 HGF -0.016 0.101 0.294 1.0 -0.29 34.0 35.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.071 0.048 0.147 4.0 -0.166 1.0 5.0 actin cable formation 0.074 0.119 0.242 74.0 -0.23 3.0 77.0 KIAA1543 0.023 0.025 0.166 4.0 -9999.0 0.0 4.0 KIFC3 0.036 0.027 0.191 2.0 -9999.0 0.0 2.0 NCK1 0.015 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.017 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.037 0.029 0.18 4.0 -9999.0 0.0 4.0 NCK1/GIT1 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.139 0.071 0.18 218.0 -9999.0 0.0 218.0 EXOC4 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.037 0.027 0.191 2.0 -9999.0 0.0 2.0 PIP5K1C 0.036 0.029 0.18 4.0 -9999.0 0.0 4.0 LIMA1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.059 0.09 0.19 78.0 -9999.0 0.0 78.0 adherens junction assembly 0.01 0.081 0.248 3.0 -0.453 5.0 8.0 IGF-1R heterotetramer/IGF1 0.035 0.102 -9999.0 0.0 -0.156 10.0 10.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.036 0.03 0.18 4.0 -9999.0 0.0 4.0 mol:GTP 0.035 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.055 0.08 0.201 57.0 -9999.0 0.0 57.0 cortical actin cytoskeleton stabilization 0.071 0.048 0.151 5.0 -0.165 1.0 6.0 regulation of cell-cell adhesion 0.027 0.028 0.167 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.071 0.048 0.147 4.0 -0.166 1.0 5.0