Correlation between copy number variation genes (focal events) and selected clinical features
Colon Adenocarcinoma (Primary solid tumor)
28 January 2016  |  analyses__2016_01_28
Maintainer Information
Citation Information
doi:10.7908/C1BP0254
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2016): Correlation between copy number variation genes (focal events) and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C1BP0254
Overview
Introduction

This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.

Summary

Testing the association between copy number variation 66 focal events and 13 clinical features across 449 patients, 272 significant findings detected with Q value < 0.25.

  • amp_2q33.1 cnv correlated to 'PATHOLOGY_N_STAGE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_5p13.2 cnv correlated to 'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_6p21.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_8q24.21 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_M_STAGE', and 'HISTOLOGICAL_TYPE'.

  • amp_11p15.5 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGY_N_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_13q12.13 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_13q22.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_16p11.2 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_16q12.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_17q12 cnv correlated to 'PATHOLOGY_T_STAGE',  'PATHOLOGY_M_STAGE', and 'ETHNICITY'.

  • amp_17q24.1 cnv correlated to 'Time to Death',  'HISTOLOGICAL_TYPE', and 'ETHNICITY'.

  • amp_20p12.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_M_STAGE',  'RADIATION_THERAPY', and 'HISTOLOGICAL_TYPE'.

  • amp_20p11.23 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_20p11.21 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'RESIDUAL_TUMOR'.

  • amp_20q11.21 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_20q12 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_20q13.12 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_1p36.11 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_1p33 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_1p13.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_2q22.1 cnv correlated to 'NUMBER_OF_LYMPH_NODES' and 'RACE'.

  • del_3p26.1 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_3p14.2 cnv correlated to 'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_4p16.2 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR',  'NUMBER_OF_LYMPH_NODES', and 'ETHNICITY'.

  • del_4q22.1 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_4q35.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_5q12.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'NUMBER_OF_LYMPH_NODES', and 'ETHNICITY'.

  • del_5q21.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'NUMBER_OF_LYMPH_NODES', and 'ETHNICITY'.

  • del_5q22.2 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_6p25.3 cnv correlated to 'YEARS_TO_BIRTH',  'GENDER', and 'RACE'.

  • del_6q26 cnv correlated to 'Time to Death',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'NUMBER_OF_LYMPH_NODES', and 'RACE'.

  • del_7q31.1 cnv correlated to 'ETHNICITY'.

  • del_8p23.2 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'GENDER',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • del_8p22 cnv correlated to 'Time to Death',  'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_T_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'GENDER',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • del_8q11.1 cnv correlated to 'RACE'.

  • del_9p21.3 cnv correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.

  • del_10p15.3 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_10q21.1 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'NUMBER_OF_LYMPH_NODES', and 'ETHNICITY'.

  • del_10q23.31 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_10q25.2 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • del_12p13.2 cnv correlated to 'Time to Death',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_13q14.13 cnv correlated to 'PATHOLOGY_N_STAGE' and 'RACE'.

  • del_14q31.1 cnv correlated to 'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_15q11.2 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_15q15.2 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_15q21.1 cnv correlated to 'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_15q22.33 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_16p13.3 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE', and 'PATHOLOGY_T_STAGE'.

  • del_16q23.1 cnv correlated to 'Time to Death'.

  • del_17p12 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_17q24.3 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_18p11.31 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_18q12.2 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_18q21.2 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'GENDER',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_18q22.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'GENDER',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_19p13.3 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • del_20p12.1 cnv correlated to 'HISTOLOGICAL_TYPE'.

  • del_21q11.2 cnv correlated to 'PATHOLOGY_N_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_22q13.32 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between significant copy number variation of 66 focal events and 13 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 272 significant findings detected.

Clinical
Features 		Time
to
Death 		YEARS
TO
BIRTH 		PATHOLOGIC
STAGE 		PATHOLOGY
T
STAGE 		PATHOLOGY
N
STAGE 		PATHOLOGY
M
STAGE 		GENDER RADIATION
THERAPY 		HISTOLOGICAL
TYPE 		RESIDUAL
TUMOR 		NUMBER
OF
LYMPH
NODES 		RACE ETHNICITY
nCNV (%) nWild-Type logrank test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Wilcoxon-test Fisher's exact test Fisher's exact test
del 8p22 201 (45%) 248 0.0489
(0.177) 		0.0262
(0.118) 		1e-05
(0.00039) 		0.0485
(0.177) 		1e-05
(0.00039) 		4.51e-06
(0.000258) 		0.0573
(0.196) 		0.52
(0.788) 		0.00142
(0.0151) 		0.0307
(0.131) 		3.44e-07
(2.55e-05) 		0.399
(0.683) 		0.35
(0.635)
del 4p16 2 138 (31%) 311 0.0307
(0.131) 		0.868
(0.993) 		0.00063
(0.00886) 		0.473
(0.752) 		0.0008
(0.0105) 		4.25e-05
(0.00135) 		0.413
(0.693) 		0.468
(0.751) 		0.0173
(0.0883) 		0.0791
(0.25) 		0.00035
(0.00661) 		0.344
(0.632) 		0.077
(0.246)
del 8p23 2 188 (42%) 261 0.205
(0.477) 		0.0708
(0.235) 		1e-05
(0.00039) 		0.0975
(0.289) 		1e-05
(0.00039) 		2.5e-05
(0.000856) 		0.0128
(0.0714) 		0.739
(0.906) 		0.00328
(0.0271) 		0.023
(0.109) 		4.13e-06
(0.000253) 		0.393
(0.681) 		0.319
(0.604)
del 10q21 1 97 (22%) 352 0.759
(0.912) 		0.0433
(0.167) 		0.00644
(0.0453) 		0.962
(1.00) 		0.0211
(0.102) 		0.00478
(0.0359) 		1
(1.00) 		0.222
(0.5) 		0.031
(0.131) 		0.138
(0.367) 		0.01
(0.0604) 		0.586
(0.843) 		0.0413
(0.161)
del 10q25 2 108 (24%) 341 0.252
(0.534) 		0.0582
(0.197) 		0.0662
(0.221) 		0.403
(0.685) 		0.0125
(0.0711) 		0.018
(0.0904) 		1
(1.00) 		0.696
(0.898) 		0.077
(0.246) 		0.0563
(0.194) 		0.00666
(0.0461) 		1
(1.00) 		0.266
(0.552)
del 18q21 2 286 (64%) 163 0.738
(0.906) 		0.0488
(0.177) 		8e-05
(0.00214) 		0.736
(0.906) 		0.00011
(0.0027) 		8.66e-05
(0.00218) 		0.0393
(0.156) 		1
(1.00) 		1.07e-10
(2.29e-08) 		0.159
(0.405) 		8.37e-05
(0.00218) 		0.805
(0.952) 		1
(1.00)
amp 13q12 13 275 (61%) 174 0.757
(0.911) 		0.597
(0.853) 		0.00061
(0.00872) 		0.98
(1.00) 		0.00137
(0.0149) 		0.00114
(0.0128) 		0.846
(0.98) 		1
(1.00) 		1.77e-07
(1.9e-05) 		0.0275
(0.122) 		0.0023
(0.0219) 		0.147
(0.385) 		1
(1.00)
amp 13q22 1 277 (62%) 172 0.708
(0.904) 		0.773
(0.924) 		0.00019
(0.00418) 		0.906
(1.00) 		0.00023
(0.00481) 		0.00306
(0.0267) 		0.331
(0.616) 		1
(1.00) 		1.68e-07
(1.9e-05) 		0.0571
(0.196) 		0.0021
(0.0207) 		0.122
(0.346) 		1
(1.00)
amp 20p11 23 219 (49%) 230 0.297
(0.592) 		0.725
(0.904) 		0.00081
(0.0105) 		0.866
(0.993) 		0.052
(0.184) 		0.000326
(0.00636) 		0.298
(0.593) 		0.324
(0.609) 		0.0132
(0.0728) 		0.0159
(0.0836) 		0.0775
(0.246) 		0.396
(0.682) 		1
(1.00)
del 1p36 11 167 (37%) 282 0.0473
(0.175) 		0.0802
(0.251) 		0.00042
(0.00735) 		0.737
(0.906) 		0.0172
(0.0883) 		1.79e-05
(0.00064) 		0.118
(0.337) 		0.493
(0.769) 		0.000585
(0.00872) 		0.124
(0.348) 		0.00356
(0.0286) 		0.113
(0.327) 		0.631
(0.877)
del 1p33 123 (27%) 326 0.00283
(0.0258) 		0.946
(1.00) 		0.0232
(0.109) 		0.316
(0.603) 		0.0294
(0.128) 		0.00541
(0.0404) 		0.397
(0.683) 		1
(1.00) 		0.0138
(0.0748) 		0.236
(0.516) 		0.00833
(0.0541) 		0.309
(0.597) 		0.316
(0.603)
del 3p26 1 71 (16%) 378 0.0786
(0.249) 		0.413
(0.693) 		0.034
(0.14) 		0.133
(0.361) 		0.00878
(0.0564) 		0.000589
(0.00872) 		0.699
(0.898) 		0.367
(0.653) 		0.025
(0.114) 		0.159
(0.405) 		0.0116
(0.0675) 		0.957
(1.00) 		0.123
(0.346)
del 4q22 1 150 (33%) 299 0.0395
(0.156) 		0.352
(0.635) 		0.00979
(0.06) 		0.167
(0.415) 		0.0008
(0.0105) 		0.0204
(0.0992) 		0.318
(0.603) 		0.725
(0.904) 		0.00374
(0.0295) 		0.806
(0.952) 		0.000307
(0.00612) 		0.226
(0.506) 		0.123
(0.346)
del 5q12 1 105 (23%) 344 0.123
(0.346) 		0.0972
(0.289) 		0.00355
(0.0286) 		0.875
(0.996) 		0.0147
(0.0791) 		0.0216
(0.104) 		0.22
(0.498) 		1
(1.00) 		0.0356
(0.144) 		0.434
(0.717) 		0.006
(0.0433) 		0.364
(0.65) 		0.051
(0.182)
del 10q23 31 108 (24%) 341 0.588
(0.843) 		0.00317
(0.0267) 		0.0122
(0.0696) 		0.895
(1.00) 		0.04
(0.157) 		0.0167
(0.0865) 		0.581
(0.843) 		0.702
(0.899) 		0.0765
(0.246) 		0.285
(0.578) 		0.00894
(0.0564) 		0.778
(0.928) 		0.284
(0.578)
del 17p12 252 (56%) 197 0.481
(0.76) 		0.0249
(0.114) 		1e-05
(0.00039) 		0.837
(0.975) 		1e-05
(0.00039) 		0.000496
(0.00805) 		0.155
(0.398) 		1
(1.00) 		3.56e-07
(2.55e-05) 		0.258
(0.543) 		1.94e-06
(0.000128) 		0.703
(0.899) 		0.635
(0.878)
del 18p11 31 247 (55%) 202 0.363
(0.65) 		0.0517
(0.183) 		0.00019
(0.00418) 		0.946
(1.00) 		0.0105
(0.0617) 		1.47e-05
(0.00055) 		0.448
(0.733) 		1
(1.00) 		2.97e-11
(1.27e-08) 		0.129
(0.353) 		0.0304
(0.131) 		0.683
(0.895) 		0.632
(0.877)
del 18q12 2 272 (61%) 177 0.675
(0.892) 		0.0258
(0.116) 		0.00122
(0.0134) 		0.663
(0.89) 		0.0011
(0.0128) 		0.00114
(0.0128) 		0.123
(0.346) 		1
(1.00) 		9.05e-11
(2.29e-08) 		0.222
(0.5) 		0.00262
(0.0244) 		0.916
(1.00) 		1
(1.00)
del 18q22 1 285 (63%) 164 0.847
(0.98) 		0.0989
(0.293) 		4e-05
(0.00132) 		0.762
(0.914) 		0.00019
(0.00418) 		5.17e-05
(0.00153) 		0.031
(0.131) 		1
(1.00) 		1.29e-11
(1.1e-08) 		0.323
(0.609) 		0.000261
(0.00533) 		0.837
(0.975) 		1
(1.00)
amp 20q11 21 321 (71%) 128 0.842
(0.978) 		0.52
(0.788) 		0.0147
(0.0791) 		0.19
(0.456) 		0.00784
(0.0521) 		0.00596
(0.0433) 		0.209
(0.484) 		1
(1.00) 		2.02e-07
(1.92e-05) 		0.164
(0.412) 		0.0189
(0.0938) 		0.827
(0.97) 		1
(1.00)
amp 20q12 322 (72%) 127 0.716
(0.904) 		0.52
(0.788) 		0.00602
(0.0433) 		0.286
(0.578) 		0.0104
(0.0617) 		0.00217
(0.0212) 		0.173
(0.425) 		1
(1.00) 		2.8e-08
(4.8e-06) 		0.165
(0.412) 		0.0198
(0.0976) 		0.743
(0.906) 		1
(1.00)
amp 20q13 12 324 (72%) 125 0.975
(1.00) 		0.625
(0.875) 		0.00309
(0.0267) 		0.399
(0.683) 		0.00562
(0.0416) 		0.0011
(0.0128) 		0.171
(0.422) 		1
(1.00) 		7.27e-08
(1.04e-05) 		0.164
(0.412) 		0.00643
(0.0453) 		0.648
(0.883) 		1
(1.00)
del 1p13 1 118 (26%) 331 0.0952
(0.286) 		0.498
(0.773) 		0.00654
(0.0456) 		0.488
(0.767) 		0.00958
(0.0591) 		0.00306
(0.0267) 		0.238
(0.517) 		1
(1.00) 		0.045
(0.169) 		0.223
(0.501) 		0.00107
(0.0128) 		0.24
(0.52) 		0.303
(0.597)
del 4q35 1 157 (35%) 292 0.44
(0.725) 		0.107
(0.313) 		0.0482
(0.177) 		0.351
(0.635) 		0.00321
(0.0267) 		0.00998
(0.0604) 		0.375
(0.66) 		0.294
(0.587) 		0.0623
(0.21) 		0.466
(0.748) 		0.000771
(0.0105) 		0.1
(0.296) 		0.126
(0.35)
del 5q21 1 126 (28%) 323 0.134
(0.363) 		0.157
(0.404) 		5e-05
(0.00153) 		1
(1.00) 		0.00158
(0.0163) 		0.00895
(0.0564) 		0.248
(0.529) 		1
(1.00) 		0.543
(0.818) 		0.323
(0.609) 		0.000501
(0.00805) 		0.453
(0.735) 		0.077
(0.246)
del 6q26 61 (14%) 388 0.0238
(0.111) 		0.907
(1.00) 		0.142
(0.375) 		0.519
(0.788) 		0.00272
(0.0251) 		0.0264
(0.118) 		0.679
(0.892) 		0.328
(0.613) 		1
(1.00) 		0.166
(0.413) 		0.00099
(0.0125) 		0.0433
(0.167) 		1
(1.00)
del 12p13 2 60 (13%) 389 0.047
(0.175) 		0.16
(0.406) 		0.147
(0.385) 		0.85
(0.982) 		0.0712
(0.235) 		0.0601
(0.203) 		0.68
(0.892) 		1
(1.00) 		0.00825
(0.054) 		0.587
(0.843) 		0.075
(0.246) 		0.736
(0.906) 		1
(1.00)
del 15q11 2 176 (39%) 273 0.718
(0.904) 		0.668
(0.892) 		0.0295
(0.128) 		0.977
(1.00) 		0.015
(0.0801) 		0.00316
(0.0267) 		0.561
(0.832) 		0.744
(0.906) 		0.0245
(0.114) 		0.559
(0.832) 		0.00748
(0.0501) 		0.405
(0.686) 		0.649
(0.883)
del 15q15 2 171 (38%) 278 0.554
(0.826) 		0.259
(0.543) 		0.0252
(0.114) 		0.951
(1.00) 		0.013
(0.0721) 		0.00037
(0.00661) 		0.56
(0.832) 		0.741
(0.906) 		0.0167
(0.0865) 		0.335
(0.622) 		0.0137
(0.0748) 		0.28
(0.573) 		0.643
(0.883)
del 15q22 33 160 (36%) 289 0.68
(0.892) 		0.457
(0.739) 		0.0203
(0.0992) 		0.589
(0.843) 		0.0156
(0.0826) 		0.000507
(0.00805) 		0.49
(0.767) 		0.727
(0.904) 		0.0226
(0.108) 		0.511
(0.786) 		0.00948
(0.0589) 		0.236
(0.516) 		0.628
(0.877)
del 17q24 3 69 (15%) 380 0.0711
(0.235) 		0.307
(0.597) 		0.00308
(0.0267) 		0.316
(0.603) 		0.0019
(0.019) 		0.00317
(0.0267) 		0.36
(0.648) 		1
(1.00) 		1
(1.00) 		0.292
(0.587) 		7.89e-05
(0.00214) 		0.276
(0.57) 		1
(1.00)
del 19p13 3 63 (14%) 386 0.526
(0.796) 		0.0816
(0.253) 		0.00228
(0.0219) 		0.775
(0.925) 		6e-05
(0.00172) 		0.0285
(0.126) 		0.341
(0.63) 		1
(1.00) 		0.171
(0.422) 		0.0351
(0.143) 		5.08e-06
(0.000273) 		0.889
(1.00) 		1
(1.00)
del 22q13 32 158 (35%) 291 0.21
(0.485) 		0.394
(0.681) 		0.00101
(0.0126) 		0.716
(0.904) 		0.0005
(0.00805) 		0.00399
(0.0308) 		0.621
(0.873) 		1
(1.00) 		0.00152
(0.0159) 		0.508
(0.783) 		0.000214
(0.0046) 		0.339
(0.629) 		0.61
(0.863)
amp 8q24 21 258 (57%) 191 0.346
(0.633) 		0.0558
(0.193) 		0.0293
(0.128) 		0.33
(0.615) 		0.236
(0.516) 		0.0128
(0.0714) 		0.251
(0.534) 		1
(1.00) 		0.0376
(0.15) 		0.362
(0.649) 		0.178
(0.431) 		0.585
(0.843) 		1
(1.00)
amp 11p15 5 91 (20%) 358 0.746
(0.906) 		0.0101
(0.0604) 		0.442
(0.726) 		0.245
(0.529) 		0.0501
(0.179) 		0.128
(0.353) 		0.725
(0.904) 		0.692
(0.898) 		0.00317
(0.0267) 		0.532
(0.803) 		0.0449
(0.169) 		0.318
(0.603) 		1
(1.00)
amp 16p11 2 125 (28%) 324 0.589
(0.843) 		0.325
(0.609) 		0.00059
(0.00872) 		0.451
(0.734) 		0.00037
(0.00661) 		0.286
(0.578) 		0.752
(0.908) 		1
(1.00) 		0.0019
(0.019) 		0.876
(0.996) 		0.000156
(0.00373) 		0.498
(0.773) 		0.31
(0.597)
amp 16q12 1 111 (25%) 338 0.134
(0.361) 		0.141
(0.373) 		0.00037
(0.00661) 		0.867
(0.993) 		0.00104
(0.0127) 		0.872
(0.995) 		0.662
(0.89) 		1
(1.00) 		0.00236
(0.0222) 		0.748
(0.906) 		0.000439
(0.00754) 		0.294
(0.587) 		0.259
(0.543)
amp 20p12 1 195 (43%) 254 0.257
(0.543) 		0.465
(0.748) 		0.016
(0.0839) 		0.672
(0.892) 		0.233
(0.516) 		0.000819
(0.0105) 		0.217
(0.495) 		0.0447
(0.169) 		0.0376
(0.15) 		0.0817
(0.253) 		0.198
(0.466) 		0.577
(0.843) 		0.646
(0.883)
amp 20p11 21 251 (56%) 198 0.517
(0.788) 		0.723
(0.904) 		0.00174
(0.0178) 		0.546
(0.821) 		0.232
(0.516) 		0.000572
(0.00872) 		0.184
(0.444) 		0.309
(0.597) 		0.00143
(0.0151) 		0.0408
(0.16) 		0.344
(0.632) 		0.824
(0.967) 		0.632
(0.877)
del 5q22 2 129 (29%) 320 0.115
(0.328) 		0.247
(0.529) 		0.0045
(0.0343) 		0.996
(1.00) 		0.0416
(0.161) 		0.00342
(0.0279) 		0.0952
(0.286) 		0.712
(0.904) 		0.174
(0.427) 		0.112
(0.324) 		0.0182
(0.091) 		0.416
(0.695) 		0.0797
(0.251)
del 10p15 3 78 (17%) 371 0.976
(1.00) 		0.341
(0.63) 		0.00115
(0.0128) 		0.904
(1.00) 		0.011
(0.064) 		0.00106
(0.0128) 		0.901
(1.00) 		0.686
(0.897) 		0.37
(0.654) 		0.676
(0.892) 		0.00361
(0.0286) 		0.516
(0.788) 		0.565
(0.834)
del 14q31 1 149 (33%) 300 0.709
(0.904) 		0.209
(0.484) 		0.306
(0.597) 		0.309
(0.597) 		0.031
(0.131) 		0.00929
(0.0582) 		0.367
(0.653) 		0.724
(0.904) 		3.01e-07
(2.55e-05) 		0.365
(0.651) 		0.0126
(0.0711) 		0.939
(1.00) 		1
(1.00)
del 15q21 1 168 (37%) 281 0.389
(0.676) 		0.639
(0.881) 		0.105
(0.309) 		0.994
(1.00) 		0.0551
(0.192) 		0.000651
(0.00901) 		0.38
(0.666) 		0.735
(0.906) 		0.0233
(0.109) 		0.159
(0.405) 		0.0482
(0.177) 		0.195
(0.46) 		0.625
(0.875)
amp 2q33 1 92 (20%) 357 0.083
(0.255) 		0.572
(0.842) 		0.308
(0.597) 		0.702
(0.899) 		0.012
(0.0694) 		0.385
(0.671) 		0.414
(0.694) 		0.69
(0.898) 		0.615
(0.866) 		0.0472
(0.175) 		0.0105
(0.0617) 		0.247
(0.529) 		0.235
(0.516)
amp 5p13 2 86 (19%) 363 0.611
(0.864) 		0.0815
(0.253) 		0.0944
(0.285) 		0.51
(0.785) 		0.0326
(0.136) 		0.0771
(0.246) 		0.472
(0.752) 		1
(1.00) 		1
(1.00) 		0.167
(0.415) 		0.0177
(0.0892) 		0.284
(0.578) 		0.581
(0.843)
amp 6p21 1 96 (21%) 353 0.934
(1.00) 		0.689
(0.898) 		0.0351
(0.143) 		0.623
(0.875) 		0.00701
(0.0474) 		0.317
(0.603) 		0.302
(0.597) 		1
(1.00) 		0.184
(0.444) 		0.713
(0.904) 		0.00674
(0.0462) 		0.161
(0.406) 		0.577
(0.843)
amp 17q12 114 (25%) 335 0.136
(0.364) 		0.35
(0.635) 		0.19
(0.456) 		0.0646
(0.217) 		0.148
(0.386) 		0.00387
(0.0302) 		0.194
(0.46) 		0.698
(0.898) 		0.159
(0.405) 		0.216
(0.495) 		0.139
(0.37) 		0.306
(0.597) 		0.0575
(0.196)
amp 17q24 1 106 (24%) 343 0.0345
(0.141) 		0.552
(0.824) 		0.689
(0.898) 		0.195
(0.46) 		0.371
(0.655) 		0.141
(0.373) 		0.739
(0.906) 		0.695
(0.898) 		0.0767
(0.246) 		0.347
(0.633) 		0.754
(0.908) 		0.803
(0.952) 		0.049
(0.177)
del 3p14 2 87 (19%) 362 0.35
(0.635) 		0.442
(0.726) 		0.382
(0.668) 		0.15
(0.391) 		0.0726
(0.239) 		0.0533
(0.188) 		0.72
(0.904) 		0.215
(0.494) 		0.307
(0.597) 		0.813
(0.956) 		0.0248
(0.114) 		0.662
(0.89) 		0.581
(0.843)
del 6p25 3 55 (12%) 394 0.232
(0.516) 		0.0502
(0.179) 		0.745
(0.906) 		0.494
(0.77) 		0.832
(0.974) 		0.676
(0.892) 		0.0443
(0.169) 		0.3
(0.594) 		0.401
(0.683) 		0.352
(0.635) 		0.871
(0.995) 		0.0452
(0.17) 		1
(1.00)
del 16p13 3 56 (12%) 393 0.00451
(0.0343) 		0.725
(0.904) 		0.0332
(0.138) 		0.0293
(0.128) 		0.205
(0.477) 		0.204
(0.477) 		0.671
(0.892) 		0.608
(0.862) 		0.839
(0.975) 		0.421
(0.701) 		0.0942
(0.285) 		0.347
(0.633) 		0.453
(0.735)
del 21q11 2 140 (31%) 309 0.45
(0.734) 		0.861
(0.991) 		0.259
(0.543) 		0.4
(0.683) 		0.0436
(0.167) 		0.137
(0.367) 		0.838
(0.975) 		0.475
(0.753) 		0.00061
(0.00872) 		0.551
(0.824) 		0.0555
(0.193) 		0.564
(0.834) 		0.091
(0.277)
del 2q22 1 24 (5%) 425 0.783
(0.931) 		0.754
(0.908) 		0.202
(0.475) 		0.283
(0.578) 		0.0831
(0.255) 		1
(1.00) 		0.676
(0.892) 		1
(1.00) 		1
(1.00) 		0.736
(0.906) 		0.00893
(0.0564) 		0.00605
(0.0433) 		1
(1.00)
del 9p21 3 61 (14%) 388 0.879
(0.996) 		0.0761
(0.246) 		0.679
(0.892) 		0.652
(0.883) 		0.394
(0.681) 		0.699
(0.898) 		0.129
(0.353) 		0.37
(0.654) 		0.00824
(0.054) 		0.246
(0.529) 		0.125
(0.348) 		0.401
(0.683) 		0.443
(0.726)
del 13q14 13 19 (4%) 430 0.905
(1.00) 		0.194
(0.46) 		0.294
(0.587) 		0.712
(0.904) 		0.0366
(0.148) 		1
(1.00) 		0.815
(0.958) 		1
(1.00) 		1
(1.00) 		0.878
(0.996) 		0.136
(0.365) 		0.0314
(0.131) 		1
(1.00)
del 7q31 1 13 (3%) 436 0.483
(0.762) 		0.905
(1.00) 		0.727
(0.904) 		0.574
(0.843) 		1
(1.00) 		1
(1.00) 		0.78
(0.928) 		0.235
(0.516) 		1
(1.00) 		1
(1.00) 		0.694
(0.898) 		0.804
(0.952) 		0.00699
(0.0474)
del 8q11 1 30 (7%) 419 0.976
(1.00) 		0.413
(0.693) 		0.114
(0.328) 		0.632
(0.877) 		0.13
(0.356) 		0.406
(0.686) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		0.584
(0.843) 		0.0965
(0.288) 		0.0545
(0.191) 		1
(1.00)
del 16q23 1 60 (13%) 389 0.0176
(0.0892) 		0.654
(0.885) 		0.902
(1.00) 		0.644
(0.883) 		0.572
(0.842) 		0.316
(0.603) 		0.491
(0.767) 		1
(1.00) 		0.548
(0.821) 		0.85
(0.982) 		0.435
(0.718) 		0.0849
(0.26) 		0.0856
(0.261)
del 20p12 1 86 (19%) 363 0.131
(0.357) 		0.656
(0.886) 		0.664
(0.891) 		0.549
(0.822) 		0.434
(0.717) 		0.866
(0.993) 		0.811
(0.956) 		0.219
(0.496) 		0.0217
(0.104) 		0.471
(0.752) 		0.252
(0.534) 		0.422
(0.703) 		1
(1.00)
amp 8p11 23 157 (35%) 292 0.388
(0.675) 		0.377
(0.662) 		0.478
(0.756) 		0.671
(0.892) 		0.695
(0.898) 		0.773
(0.924) 		0.767
(0.919) 		0.725
(0.904) 		0.115
(0.328) 		0.645
(0.883) 		0.693
(0.898) 		0.6
(0.855) 		1
(1.00)
amp 8p11 21 187 (42%) 262 0.52
(0.788) 		0.309
(0.597) 		0.648
(0.883) 		0.508
(0.783) 		0.667
(0.892) 		0.491
(0.767) 		0.151
(0.391) 		0.505
(0.782) 		0.211
(0.486) 		0.193
(0.46) 		0.742
(0.906) 		0.234
(0.516) 		0.638
(0.88)
amp 12p13 33 112 (25%) 337 0.246
(0.529) 		0.268
(0.556) 		0.218
(0.495) 		0.153
(0.396) 		0.266
(0.552) 		0.752
(0.908) 		0.743
(0.906) 		1
(1.00) 		0.875
(0.996) 		0.244
(0.528) 		0.376
(0.661) 		0.519
(0.788) 		0.575
(0.843)
amp 17p11 2 44 (10%) 405 0.588
(0.843) 		0.613
(0.866) 		0.587
(0.843) 		0.472
(0.752) 		0.635
(0.878) 		0.65
(0.883) 		0.634
(0.878) 		1
(1.00) 		1
(1.00) 		0.859
(0.991) 		0.68
(0.892) 		0.177
(0.431) 		1
(1.00)
amp 19q13 11 95 (21%) 354 0.292
(0.587) 		0.953
(1.00) 		0.717
(0.904) 		0.471
(0.752) 		0.112
(0.324) 		0.233
(0.516) 		0.107
(0.313) 		0.417
(0.697) 		0.741
(0.906) 		0.868
(0.993) 		0.734
(0.906) 		0.972
(1.00) 		1
(1.00)
del 2p21 17 (4%) 432 0.96
(1.00) 		0.456
(0.738) 		0.177
(0.431) 		0.647
(0.883) 		0.406
(0.686) 		0.328
(0.613) 		0.805
(0.952) 		1
(1.00) 		0.488
(0.767) 		0.663
(0.89) 		0.464
(0.748) 		0.607
(0.862) 		0.126
(0.35)
del 3q26 31 46 (10%) 403 0.908
(1.00) 		0.43
(0.713) 		0.277
(0.57) 		0.276
(0.57) 		0.194
(0.46) 		0.263
(0.548) 		0.535
(0.807) 		0.606
(0.862) 		0.175
(0.429) 		0.836
(0.975) 		0.278
(0.57) 		0.587
(0.843) 		1
(1.00)
'amp_2q33.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.012 (Fisher's exact test), Q value = 0.069

Table S1.  Gene #1: 'amp_2q33.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 1(2Q33.1) MUTATED 43 23 26
AMP PEAK 1(2Q33.1) WILD-TYPE 219 82 56

Figure S1.  Get High-res Image Gene #1: 'amp_2q33.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_2q33.1' versus 'RESIDUAL_TUMOR'

P value = 0.0472 (Fisher's exact test), Q value = 0.18

Table S2.  Gene #1: 'amp_2q33.1' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 323 4 25 25
AMP PEAK 1(2Q33.1) MUTATED 59 3 6 6
AMP PEAK 1(2Q33.1) WILD-TYPE 264 1 19 19

Figure S2.  Get High-res Image Gene #1: 'amp_2q33.1' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

'amp_2q33.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0105 (Wilcoxon-test), Q value = 0.062

Table S3.  Gene #1: 'amp_2q33.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 1(2Q33.1) MUTATED 89 2.8 (4.4)
AMP PEAK 1(2Q33.1) WILD-TYPE 335 1.9 (4.4)

Figure S3.  Get High-res Image Gene #1: 'amp_2q33.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_5p13.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.0326 (Fisher's exact test), Q value = 0.14

Table S4.  Gene #2: 'amp_5p13.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 2(5P13.2) MUTATED 42 20 24
AMP PEAK 2(5P13.2) WILD-TYPE 220 85 58

Figure S4.  Get High-res Image Gene #2: 'amp_5p13.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_5p13.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.0771 (Fisher's exact test), Q value = 0.25

Table S5.  Gene #2: 'amp_5p13.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 2(5P13.2) MUTATED 55 17
AMP PEAK 2(5P13.2) WILD-TYPE 273 47

Figure S5.  Get High-res Image Gene #2: 'amp_5p13.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_5p13.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0177 (Wilcoxon-test), Q value = 0.089

Table S6.  Gene #2: 'amp_5p13.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 2(5P13.2) MUTATED 83 3.0 (4.6)
AMP PEAK 2(5P13.2) WILD-TYPE 341 1.9 (4.4)

Figure S6.  Get High-res Image Gene #2: 'amp_5p13.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_6p21.1' versus 'PATHOLOGIC_STAGE'

P value = 0.0351 (Fisher's exact test), Q value = 0.14

Table S7.  Gene #3: 'amp_6p21.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 3(6P21.1) MUTATED 13 0 2 24 1 0 2 4 15 15 10 6 1
AMP PEAK 3(6P21.1) WILD-TYPE 61 1 27 108 9 1 18 4 44 26 35 11 1

Figure S7.  Get High-res Image Gene #3: 'amp_6p21.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_6p21.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00701 (Fisher's exact test), Q value = 0.047

Table S8.  Gene #3: 'amp_6p21.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 3(6P21.1) MUTATED 46 22 28
AMP PEAK 3(6P21.1) WILD-TYPE 216 83 54

Figure S8.  Get High-res Image Gene #3: 'amp_6p21.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_6p21.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00674 (Wilcoxon-test), Q value = 0.046

Table S9.  Gene #3: 'amp_6p21.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 3(6P21.1) MUTATED 93 3.3 (5.6)
AMP PEAK 3(6P21.1) WILD-TYPE 331 1.7 (4.0)

Figure S9.  Get High-res Image Gene #3: 'amp_6p21.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_8q24.21' versus 'YEARS_TO_BIRTH'

P value = 0.0558 (Wilcoxon-test), Q value = 0.19

Table S10.  Gene #6: 'amp_8q24.21' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
AMP PEAK 6(8Q24.21) MUTATED 257 66.0 (12.9)
AMP PEAK 6(8Q24.21) WILD-TYPE 190 68.1 (13.3)

Figure S10.  Get High-res Image Gene #6: 'amp_8q24.21' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'amp_8q24.21' versus 'PATHOLOGIC_STAGE'

P value = 0.0293 (Fisher's exact test), Q value = 0.13

Table S11.  Gene #6: 'amp_8q24.21' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 6(8Q24.21) MUTATED 41 0 19 68 3 1 9 7 34 24 33 13 0
AMP PEAK 6(8Q24.21) WILD-TYPE 33 1 10 64 7 0 11 1 25 17 12 4 2

Figure S11.  Get High-res Image Gene #6: 'amp_8q24.21' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_8q24.21' versus 'PATHOLOGY_M_STAGE'

P value = 0.0128 (Fisher's exact test), Q value = 0.071

Table S12.  Gene #6: 'amp_8q24.21' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 6(8Q24.21) MUTATED 180 46
AMP PEAK 6(8Q24.21) WILD-TYPE 148 18

Figure S12.  Get High-res Image Gene #6: 'amp_8q24.21' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_8q24.21' versus 'HISTOLOGICAL_TYPE'

P value = 0.0376 (Fisher's exact test), Q value = 0.15

Table S13.  Gene #6: 'amp_8q24.21' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 6(8Q24.21) MUTATED 228 28
AMP PEAK 6(8Q24.21) WILD-TYPE 154 34

Figure S13.  Get High-res Image Gene #6: 'amp_8q24.21' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_11p15.5' versus 'YEARS_TO_BIRTH'

P value = 0.0101 (Wilcoxon-test), Q value = 0.06

Table S14.  Gene #7: 'amp_11p15.5' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
AMP PEAK 7(11P15.5) MUTATED 91 63.9 (12.7)
AMP PEAK 7(11P15.5) WILD-TYPE 356 67.7 (13.0)

Figure S14.  Get High-res Image Gene #7: 'amp_11p15.5' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'amp_11p15.5' versus 'PATHOLOGY_N_STAGE'

P value = 0.0501 (Fisher's exact test), Q value = 0.18

Table S15.  Gene #7: 'amp_11p15.5' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 7(11P15.5) MUTATED 43 27 21
AMP PEAK 7(11P15.5) WILD-TYPE 219 78 61

Figure S15.  Get High-res Image Gene #7: 'amp_11p15.5' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_11p15.5' versus 'HISTOLOGICAL_TYPE'

P value = 0.00317 (Fisher's exact test), Q value = 0.027

Table S16.  Gene #7: 'amp_11p15.5' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 7(11P15.5) MUTATED 85 4
AMP PEAK 7(11P15.5) WILD-TYPE 297 58

Figure S16.  Get High-res Image Gene #7: 'amp_11p15.5' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_11p15.5' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0449 (Wilcoxon-test), Q value = 0.17

Table S17.  Gene #7: 'amp_11p15.5' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 7(11P15.5) MUTATED 86 2.8 (6.2)
AMP PEAK 7(11P15.5) WILD-TYPE 338 1.9 (3.9)

Figure S17.  Get High-res Image Gene #7: 'amp_11p15.5' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_13q12.13' versus 'PATHOLOGIC_STAGE'

P value = 0.00061 (Fisher's exact test), Q value = 0.0087

Table S18.  Gene #9: 'amp_13q12.13' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 9(13Q12.13) MUTATED 43 0 15 69 4 1 11 8 40 26 37 14 0
AMP PEAK 9(13Q12.13) WILD-TYPE 31 1 14 63 6 0 9 0 19 15 8 3 2

Figure S18.  Get High-res Image Gene #9: 'amp_13q12.13' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_13q12.13' versus 'PATHOLOGY_N_STAGE'

P value = 0.00137 (Fisher's exact test), Q value = 0.015

Table S19.  Gene #9: 'amp_13q12.13' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 9(13Q12.13) MUTATED 142 76 57
AMP PEAK 9(13Q12.13) WILD-TYPE 120 29 25

Figure S19.  Get High-res Image Gene #9: 'amp_13q12.13' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_13q12.13' versus 'PATHOLOGY_M_STAGE'

P value = 0.00114 (Fisher's exact test), Q value = 0.013

Table S20.  Gene #9: 'amp_13q12.13' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 9(13Q12.13) MUTATED 191 51
AMP PEAK 9(13Q12.13) WILD-TYPE 137 13

Figure S20.  Get High-res Image Gene #9: 'amp_13q12.13' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_13q12.13' versus 'HISTOLOGICAL_TYPE'

P value = 1.77e-07 (Fisher's exact test), Q value = 1.9e-05

Table S21.  Gene #9: 'amp_13q12.13' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 9(13Q12.13) MUTATED 254 19
AMP PEAK 9(13Q12.13) WILD-TYPE 128 43

Figure S21.  Get High-res Image Gene #9: 'amp_13q12.13' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_13q12.13' versus 'RESIDUAL_TUMOR'

P value = 0.0275 (Fisher's exact test), Q value = 0.12

Table S22.  Gene #9: 'amp_13q12.13' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 323 4 25 25
AMP PEAK 9(13Q12.13) MUTATED 195 2 20 10
AMP PEAK 9(13Q12.13) WILD-TYPE 128 2 5 15

Figure S22.  Get High-res Image Gene #9: 'amp_13q12.13' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

'amp_13q12.13' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0023 (Wilcoxon-test), Q value = 0.022

Table S23.  Gene #9: 'amp_13q12.13' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 9(13Q12.13) MUTATED 265 2.4 (4.8)
AMP PEAK 9(13Q12.13) WILD-TYPE 159 1.5 (3.7)

Figure S23.  Get High-res Image Gene #9: 'amp_13q12.13' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_13q22.1' versus 'PATHOLOGIC_STAGE'

P value = 0.00019 (Fisher's exact test), Q value = 0.0042

Table S24.  Gene #10: 'amp_13q22.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 10(13Q22.1) MUTATED 45 0 16 66 3 1 12 8 41 28 36 14 0
AMP PEAK 10(13Q22.1) WILD-TYPE 29 1 13 66 7 0 8 0 18 13 9 3 2

Figure S24.  Get High-res Image Gene #10: 'amp_13q22.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_13q22.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00023 (Fisher's exact test), Q value = 0.0048

Table S25.  Gene #10: 'amp_13q22.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 10(13Q22.1) MUTATED 141 78 58
AMP PEAK 10(13Q22.1) WILD-TYPE 121 27 24

Figure S25.  Get High-res Image Gene #10: 'amp_13q22.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_13q22.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.00306 (Fisher's exact test), Q value = 0.027

Table S26.  Gene #10: 'amp_13q22.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 10(13Q22.1) MUTATED 192 50
AMP PEAK 10(13Q22.1) WILD-TYPE 136 14

Figure S26.  Get High-res Image Gene #10: 'amp_13q22.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_13q22.1' versus 'HISTOLOGICAL_TYPE'

P value = 1.68e-07 (Fisher's exact test), Q value = 1.9e-05

Table S27.  Gene #10: 'amp_13q22.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 10(13Q22.1) MUTATED 255 19
AMP PEAK 10(13Q22.1) WILD-TYPE 127 43

Figure S27.  Get High-res Image Gene #10: 'amp_13q22.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_13q22.1' versus 'RESIDUAL_TUMOR'

P value = 0.0571 (Fisher's exact test), Q value = 0.2

Table S28.  Gene #10: 'amp_13q22.1' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 323 4 25 25
AMP PEAK 10(13Q22.1) MUTATED 196 2 19 10
AMP PEAK 10(13Q22.1) WILD-TYPE 127 2 6 15

Figure S28.  Get High-res Image Gene #10: 'amp_13q22.1' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

'amp_13q22.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0021 (Wilcoxon-test), Q value = 0.021

Table S29.  Gene #10: 'amp_13q22.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 10(13Q22.1) MUTATED 269 2.4 (4.8)
AMP PEAK 10(13Q22.1) WILD-TYPE 155 1.5 (3.7)

Figure S29.  Get High-res Image Gene #10: 'amp_13q22.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_16p11.2' versus 'PATHOLOGIC_STAGE'

P value = 0.00059 (Fisher's exact test), Q value = 0.0087

Table S30.  Gene #11: 'amp_16p11.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 11(16P11.2) MUTATED 14 1 3 30 1 0 6 7 19 17 15 5 1
AMP PEAK 11(16P11.2) WILD-TYPE 60 0 26 102 9 1 14 1 40 24 30 12 1

Figure S30.  Get High-res Image Gene #11: 'amp_16p11.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_16p11.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.00037 (Fisher's exact test), Q value = 0.0066

Table S31.  Gene #11: 'amp_16p11.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 11(16P11.2) MUTATED 55 37 33
AMP PEAK 11(16P11.2) WILD-TYPE 207 68 49

Figure S31.  Get High-res Image Gene #11: 'amp_16p11.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_16p11.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0019 (Fisher's exact test), Q value = 0.019

Table S32.  Gene #11: 'amp_16p11.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 11(16P11.2) MUTATED 115 7
AMP PEAK 11(16P11.2) WILD-TYPE 267 55

Figure S32.  Get High-res Image Gene #11: 'amp_16p11.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_16p11.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000156 (Wilcoxon-test), Q value = 0.0037

Table S33.  Gene #11: 'amp_16p11.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 11(16P11.2) MUTATED 119 3.2 (6.2)
AMP PEAK 11(16P11.2) WILD-TYPE 305 1.6 (3.4)

Figure S33.  Get High-res Image Gene #11: 'amp_16p11.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_16q12.1' versus 'PATHOLOGIC_STAGE'

P value = 0.00037 (Fisher's exact test), Q value = 0.0066

Table S34.  Gene #12: 'amp_16q12.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 12(16Q12.1) MUTATED 14 1 3 23 1 0 6 7 19 15 11 4 1
AMP PEAK 12(16Q12.1) WILD-TYPE 60 0 26 109 9 1 14 1 40 26 34 13 1

Figure S34.  Get High-res Image Gene #12: 'amp_16q12.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_16q12.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00104 (Fisher's exact test), Q value = 0.013

Table S35.  Gene #12: 'amp_16q12.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 12(16Q12.1) MUTATED 48 35 28
AMP PEAK 12(16Q12.1) WILD-TYPE 214 70 54

Figure S35.  Get High-res Image Gene #12: 'amp_16q12.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_16q12.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.00236 (Fisher's exact test), Q value = 0.022

Table S36.  Gene #12: 'amp_16q12.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 12(16Q12.1) MUTATED 103 6
AMP PEAK 12(16Q12.1) WILD-TYPE 279 56

Figure S36.  Get High-res Image Gene #12: 'amp_16q12.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_16q12.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000439 (Wilcoxon-test), Q value = 0.0075

Table S37.  Gene #12: 'amp_16q12.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 12(16Q12.1) MUTATED 106 3.2 (6.2)
AMP PEAK 12(16Q12.1) WILD-TYPE 318 1.7 (3.6)

Figure S37.  Get High-res Image Gene #12: 'amp_16q12.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_17q12' versus 'PATHOLOGY_T_STAGE'

P value = 0.0646 (Fisher's exact test), Q value = 0.22

Table S38.  Gene #14: 'amp_17q12' versus Clinical Feature #4: 'PATHOLOGY_T_STAGE'

nPatients T1 T2 T3 T4
ALL 11 77 305 55
AMP PEAK 14(17Q12) MUTATED 5 13 85 11
AMP PEAK 14(17Q12) WILD-TYPE 6 64 220 44

Figure S38.  Get High-res Image Gene #14: 'amp_17q12' versus Clinical Feature #4: 'PATHOLOGY_T_STAGE'

'amp_17q12' versus 'PATHOLOGY_M_STAGE'

P value = 0.00387 (Fisher's exact test), Q value = 0.03

Table S39.  Gene #14: 'amp_17q12' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 14(17Q12) MUTATED 70 25
AMP PEAK 14(17Q12) WILD-TYPE 258 39

Figure S39.  Get High-res Image Gene #14: 'amp_17q12' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_17q12' versus 'ETHNICITY'

P value = 0.0575 (Fisher's exact test), Q value = 0.2

Table S40.  Gene #14: 'amp_17q12' versus Clinical Feature #13: 'ETHNICITY'

nPatients HISPANIC OR LATINO NOT HISPANIC OR LATINO
ALL 4 269
AMP PEAK 14(17Q12) MUTATED 3 69
AMP PEAK 14(17Q12) WILD-TYPE 1 200

Figure S40.  Get High-res Image Gene #14: 'amp_17q12' versus Clinical Feature #13: 'ETHNICITY'

'amp_17q24.1' versus 'Time to Death'

P value = 0.0345 (logrank test), Q value = 0.14

Table S41.  Gene #15: 'amp_17q24.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
AMP PEAK 15(17Q24.1) MUTATED 103 15 0.9 - 148.0 (24.3)
AMP PEAK 15(17Q24.1) WILD-TYPE 333 86 0.0 - 140.4 (21.8)

Figure S41.  Get High-res Image Gene #15: 'amp_17q24.1' versus Clinical Feature #1: 'Time to Death'

'amp_17q24.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0767 (Fisher's exact test), Q value = 0.25

Table S42.  Gene #15: 'amp_17q24.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 15(17Q24.1) MUTATED 96 9
AMP PEAK 15(17Q24.1) WILD-TYPE 286 53

Figure S42.  Get High-res Image Gene #15: 'amp_17q24.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_17q24.1' versus 'ETHNICITY'

P value = 0.049 (Fisher's exact test), Q value = 0.18

Table S43.  Gene #15: 'amp_17q24.1' versus Clinical Feature #13: 'ETHNICITY'

nPatients HISPANIC OR LATINO NOT HISPANIC OR LATINO
ALL 4 269
AMP PEAK 15(17Q24.1) MUTATED 3 65
AMP PEAK 15(17Q24.1) WILD-TYPE 1 204

Figure S43.  Get High-res Image Gene #15: 'amp_17q24.1' versus Clinical Feature #13: 'ETHNICITY'

'amp_20p12.1' versus 'PATHOLOGIC_STAGE'

P value = 0.016 (Fisher's exact test), Q value = 0.084

Table S44.  Gene #17: 'amp_20p12.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 17(20P12.1) MUTATED 36 1 10 48 3 0 7 6 21 17 30 9 1
AMP PEAK 17(20P12.1) WILD-TYPE 38 0 19 84 7 1 13 2 38 24 15 8 1

Figure S44.  Get High-res Image Gene #17: 'amp_20p12.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_20p12.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.000819 (Fisher's exact test), Q value = 0.01

Table S45.  Gene #17: 'amp_20p12.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 17(20P12.1) MUTATED 128 40
AMP PEAK 17(20P12.1) WILD-TYPE 200 24

Figure S45.  Get High-res Image Gene #17: 'amp_20p12.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_20p12.1' versus 'RADIATION_THERAPY'

P value = 0.0447 (Fisher's exact test), Q value = 0.17

Table S46.  Gene #17: 'amp_20p12.1' versus Clinical Feature #8: 'RADIATION_THERAPY'

nPatients NO YES
ALL 370 9
AMP PEAK 17(20P12.1) MUTATED 158 7
AMP PEAK 17(20P12.1) WILD-TYPE 212 2

Figure S46.  Get High-res Image Gene #17: 'amp_20p12.1' versus Clinical Feature #8: 'RADIATION_THERAPY'

'amp_20p12.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0376 (Fisher's exact test), Q value = 0.15

Table S47.  Gene #17: 'amp_20p12.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 17(20P12.1) MUTATED 174 19
AMP PEAK 17(20P12.1) WILD-TYPE 208 43

Figure S47.  Get High-res Image Gene #17: 'amp_20p12.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_20p11.23' versus 'PATHOLOGIC_STAGE'

P value = 0.00081 (Fisher's exact test), Q value = 0.01

Table S48.  Gene #18: 'amp_20p11.23' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 18(20P11.23) MUTATED 35 1 11 57 3 0 9 8 25 19 34 10 1
AMP PEAK 18(20P11.23) WILD-TYPE 39 0 18 75 7 1 11 0 34 22 11 7 1

Figure S48.  Get High-res Image Gene #18: 'amp_20p11.23' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_20p11.23' versus 'PATHOLOGY_N_STAGE'

P value = 0.052 (Fisher's exact test), Q value = 0.18

Table S49.  Gene #18: 'amp_20p11.23' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 18(20P11.23) MUTATED 116 61 42
AMP PEAK 18(20P11.23) WILD-TYPE 146 44 40

Figure S49.  Get High-res Image Gene #18: 'amp_20p11.23' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_20p11.23' versus 'PATHOLOGY_M_STAGE'

P value = 0.000326 (Fisher's exact test), Q value = 0.0064

Table S50.  Gene #18: 'amp_20p11.23' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 18(20P11.23) MUTATED 148 45
AMP PEAK 18(20P11.23) WILD-TYPE 180 19

Figure S50.  Get High-res Image Gene #18: 'amp_20p11.23' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_20p11.23' versus 'HISTOLOGICAL_TYPE'

P value = 0.0132 (Fisher's exact test), Q value = 0.073

Table S51.  Gene #18: 'amp_20p11.23' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 18(20P11.23) MUTATED 197 21
AMP PEAK 18(20P11.23) WILD-TYPE 185 41

Figure S51.  Get High-res Image Gene #18: 'amp_20p11.23' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_20p11.23' versus 'RESIDUAL_TUMOR'

P value = 0.0159 (Fisher's exact test), Q value = 0.084

Table S52.  Gene #18: 'amp_20p11.23' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 323 4 25 25
AMP PEAK 18(20P11.23) MUTATED 149 3 19 11
AMP PEAK 18(20P11.23) WILD-TYPE 174 1 6 14

Figure S52.  Get High-res Image Gene #18: 'amp_20p11.23' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

'amp_20p11.23' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0775 (Wilcoxon-test), Q value = 0.25

Table S53.  Gene #18: 'amp_20p11.23' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 18(20P11.23) MUTATED 208 2.3 (4.9)
AMP PEAK 18(20P11.23) WILD-TYPE 216 1.8 (3.9)

Figure S53.  Get High-res Image Gene #18: 'amp_20p11.23' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_20p11.21' versus 'PATHOLOGIC_STAGE'

P value = 0.00174 (Fisher's exact test), Q value = 0.018

Table S54.  Gene #19: 'amp_20p11.21' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 19(20P11.21) MUTATED 43 1 15 66 3 0 8 8 29 22 36 11 1
AMP PEAK 19(20P11.21) WILD-TYPE 31 0 14 66 7 1 12 0 30 19 9 6 1

Figure S54.  Get High-res Image Gene #19: 'amp_20p11.21' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_20p11.21' versus 'PATHOLOGY_M_STAGE'

P value = 0.000572 (Fisher's exact test), Q value = 0.0087

Table S55.  Gene #19: 'amp_20p11.21' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 19(20P11.21) MUTATED 170 48
AMP PEAK 19(20P11.21) WILD-TYPE 158 16

Figure S55.  Get High-res Image Gene #19: 'amp_20p11.21' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_20p11.21' versus 'HISTOLOGICAL_TYPE'

P value = 0.00143 (Fisher's exact test), Q value = 0.015

Table S56.  Gene #19: 'amp_20p11.21' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 19(20P11.21) MUTATED 226 23
AMP PEAK 19(20P11.21) WILD-TYPE 156 39

Figure S56.  Get High-res Image Gene #19: 'amp_20p11.21' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_20p11.21' versus 'RESIDUAL_TUMOR'

P value = 0.0408 (Fisher's exact test), Q value = 0.16

Table S57.  Gene #19: 'amp_20p11.21' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 323 4 25 25
AMP PEAK 19(20P11.21) MUTATED 174 3 20 12
AMP PEAK 19(20P11.21) WILD-TYPE 149 1 5 13

Figure S57.  Get High-res Image Gene #19: 'amp_20p11.21' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

'amp_20q11.21' versus 'PATHOLOGIC_STAGE'

P value = 0.0147 (Fisher's exact test), Q value = 0.079

Table S58.  Gene #20: 'amp_20q11.21' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 20(20Q11.21) MUTATED 53 1 17 85 4 1 14 8 43 32 39 15 1
AMP PEAK 20(20Q11.21) WILD-TYPE 21 0 12 47 6 0 6 0 16 9 6 2 1

Figure S58.  Get High-res Image Gene #20: 'amp_20q11.21' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_20q11.21' versus 'PATHOLOGY_N_STAGE'

P value = 0.00784 (Fisher's exact test), Q value = 0.052

Table S59.  Gene #20: 'amp_20q11.21' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 20(20Q11.21) MUTATED 173 85 63
AMP PEAK 20(20Q11.21) WILD-TYPE 89 20 19

Figure S59.  Get High-res Image Gene #20: 'amp_20q11.21' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_20q11.21' versus 'PATHOLOGY_M_STAGE'

P value = 0.00596 (Fisher's exact test), Q value = 0.043

Table S60.  Gene #20: 'amp_20q11.21' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 20(20Q11.21) MUTATED 227 55
AMP PEAK 20(20Q11.21) WILD-TYPE 101 9

Figure S60.  Get High-res Image Gene #20: 'amp_20q11.21' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_20q11.21' versus 'HISTOLOGICAL_TYPE'

P value = 2.02e-07 (Fisher's exact test), Q value = 1.9e-05

Table S61.  Gene #20: 'amp_20q11.21' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 20(20Q11.21) MUTATED 291 26
AMP PEAK 20(20Q11.21) WILD-TYPE 91 36

Figure S61.  Get High-res Image Gene #20: 'amp_20q11.21' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_20q11.21' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0189 (Wilcoxon-test), Q value = 0.094

Table S62.  Gene #20: 'amp_20q11.21' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 20(20Q11.21) MUTATED 307 2.3 (4.7)
AMP PEAK 20(20Q11.21) WILD-TYPE 117 1.6 (3.5)

Figure S62.  Get High-res Image Gene #20: 'amp_20q11.21' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_20q12' versus 'PATHOLOGIC_STAGE'

P value = 0.00602 (Fisher's exact test), Q value = 0.043

Table S63.  Gene #21: 'amp_20q12' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 21(20Q12) MUTATED 53 1 17 86 4 1 13 8 43 32 39 16 1
AMP PEAK 21(20Q12) WILD-TYPE 21 0 12 46 6 0 7 0 16 9 6 1 1

Figure S63.  Get High-res Image Gene #21: 'amp_20q12' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_20q12' versus 'PATHOLOGY_N_STAGE'

P value = 0.0104 (Fisher's exact test), Q value = 0.062

Table S64.  Gene #21: 'amp_20q12' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 21(20Q12) MUTATED 174 85 63
AMP PEAK 21(20Q12) WILD-TYPE 88 20 19

Figure S64.  Get High-res Image Gene #21: 'amp_20q12' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_20q12' versus 'PATHOLOGY_M_STAGE'

P value = 0.00217 (Fisher's exact test), Q value = 0.021

Table S65.  Gene #21: 'amp_20q12' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 21(20Q12) MUTATED 227 56
AMP PEAK 21(20Q12) WILD-TYPE 101 8

Figure S65.  Get High-res Image Gene #21: 'amp_20q12' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_20q12' versus 'HISTOLOGICAL_TYPE'

P value = 2.8e-08 (Fisher's exact test), Q value = 4.8e-06

Table S66.  Gene #21: 'amp_20q12' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 21(20Q12) MUTATED 293 25
AMP PEAK 21(20Q12) WILD-TYPE 89 37

Figure S66.  Get High-res Image Gene #21: 'amp_20q12' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_20q12' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0198 (Wilcoxon-test), Q value = 0.098

Table S67.  Gene #21: 'amp_20q12' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 21(20Q12) MUTATED 307 2.3 (4.7)
AMP PEAK 21(20Q12) WILD-TYPE 117 1.6 (3.6)

Figure S67.  Get High-res Image Gene #21: 'amp_20q12' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'amp_20q13.12' versus 'PATHOLOGIC_STAGE'

P value = 0.00309 (Fisher's exact test), Q value = 0.027

Table S68.  Gene #22: 'amp_20q13.12' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
AMP PEAK 22(20Q13.12) MUTATED 52 1 18 86 4 1 13 8 43 33 40 16 1
AMP PEAK 22(20Q13.12) WILD-TYPE 22 0 11 46 6 0 7 0 16 8 5 1 1

Figure S68.  Get High-res Image Gene #22: 'amp_20q13.12' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'amp_20q13.12' versus 'PATHOLOGY_N_STAGE'

P value = 0.00562 (Fisher's exact test), Q value = 0.042

Table S69.  Gene #22: 'amp_20q13.12' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
AMP PEAK 22(20Q13.12) MUTATED 174 85 65
AMP PEAK 22(20Q13.12) WILD-TYPE 88 20 17

Figure S69.  Get High-res Image Gene #22: 'amp_20q13.12' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'amp_20q13.12' versus 'PATHOLOGY_M_STAGE'

P value = 0.0011 (Fisher's exact test), Q value = 0.013

Table S70.  Gene #22: 'amp_20q13.12' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
AMP PEAK 22(20Q13.12) MUTATED 228 57
AMP PEAK 22(20Q13.12) WILD-TYPE 100 7

Figure S70.  Get High-res Image Gene #22: 'amp_20q13.12' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'amp_20q13.12' versus 'HISTOLOGICAL_TYPE'

P value = 7.27e-08 (Fisher's exact test), Q value = 1e-05

Table S71.  Gene #22: 'amp_20q13.12' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
AMP PEAK 22(20Q13.12) MUTATED 294 26
AMP PEAK 22(20Q13.12) WILD-TYPE 88 36

Figure S71.  Get High-res Image Gene #22: 'amp_20q13.12' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'amp_20q13.12' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00643 (Wilcoxon-test), Q value = 0.045

Table S72.  Gene #22: 'amp_20q13.12' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
AMP PEAK 22(20Q13.12) MUTATED 309 2.3 (4.8)
AMP PEAK 22(20Q13.12) WILD-TYPE 115 1.4 (3.4)

Figure S72.  Get High-res Image Gene #22: 'amp_20q13.12' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_1p36.11' versus 'Time to Death'

P value = 0.0473 (logrank test), Q value = 0.18

Table S73.  Gene #23: 'del_1p36.11' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 1(1P36.11) MUTATED 162 44 0.5 - 139.2 (22.0)
DEL PEAK 1(1P36.11) WILD-TYPE 274 57 0.0 - 148.0 (22.1)

Figure S73.  Get High-res Image Gene #23: 'del_1p36.11' versus Clinical Feature #1: 'Time to Death'

'del_1p36.11' versus 'PATHOLOGIC_STAGE'

P value = 0.00042 (Fisher's exact test), Q value = 0.0074

Table S74.  Gene #23: 'del_1p36.11' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 1(1P36.11) MUTATED 21 0 6 46 2 1 7 4 18 18 30 10 0
DEL PEAK 1(1P36.11) WILD-TYPE 53 1 23 86 8 0 13 4 41 23 15 7 2

Figure S74.  Get High-res Image Gene #23: 'del_1p36.11' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_1p36.11' versus 'PATHOLOGY_N_STAGE'

P value = 0.0172 (Fisher's exact test), Q value = 0.088

Table S75.  Gene #23: 'del_1p36.11' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 1(1P36.11) MUTATED 84 43 40
DEL PEAK 1(1P36.11) WILD-TYPE 178 62 42

Figure S75.  Get High-res Image Gene #23: 'del_1p36.11' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_1p36.11' versus 'PATHOLOGY_M_STAGE'

P value = 1.79e-05 (Fisher's exact test), Q value = 0.00064

Table S76.  Gene #23: 'del_1p36.11' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 1(1P36.11) MUTATED 109 40
DEL PEAK 1(1P36.11) WILD-TYPE 219 24

Figure S76.  Get High-res Image Gene #23: 'del_1p36.11' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_1p36.11' versus 'HISTOLOGICAL_TYPE'

P value = 0.000585 (Fisher's exact test), Q value = 0.0087

Table S77.  Gene #23: 'del_1p36.11' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 1(1P36.11) MUTATED 155 11
DEL PEAK 1(1P36.11) WILD-TYPE 227 51

Figure S77.  Get High-res Image Gene #23: 'del_1p36.11' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_1p36.11' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00356 (Wilcoxon-test), Q value = 0.029

Table S78.  Gene #23: 'del_1p36.11' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 1(1P36.11) MUTATED 156 2.9 (5.7)
DEL PEAK 1(1P36.11) WILD-TYPE 268 1.6 (3.4)

Figure S78.  Get High-res Image Gene #23: 'del_1p36.11' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_1p33' versus 'Time to Death'

P value = 0.00283 (logrank test), Q value = 0.026

Table S79.  Gene #24: 'del_1p33' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 2(1P33) MUTATED 119 37 0.0 - 92.8 (21.0)
DEL PEAK 2(1P33) WILD-TYPE 317 64 0.0 - 148.0 (23.0)

Figure S79.  Get High-res Image Gene #24: 'del_1p33' versus Clinical Feature #1: 'Time to Death'

'del_1p33' versus 'PATHOLOGIC_STAGE'

P value = 0.0232 (Fisher's exact test), Q value = 0.11

Table S80.  Gene #24: 'del_1p33' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 2(1P33) MUTATED 12 0 6 35 1 0 5 3 15 15 23 4 0
DEL PEAK 2(1P33) WILD-TYPE 62 1 23 97 9 1 15 5 44 26 22 13 2

Figure S80.  Get High-res Image Gene #24: 'del_1p33' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_1p33' versus 'PATHOLOGY_N_STAGE'

P value = 0.0294 (Fisher's exact test), Q value = 0.13

Table S81.  Gene #24: 'del_1p33' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 2(1P33) MUTATED 60 33 30
DEL PEAK 2(1P33) WILD-TYPE 202 72 52

Figure S81.  Get High-res Image Gene #24: 'del_1p33' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_1p33' versus 'PATHOLOGY_M_STAGE'

P value = 0.00541 (Fisher's exact test), Q value = 0.04

Table S82.  Gene #24: 'del_1p33' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 2(1P33) MUTATED 80 27
DEL PEAK 2(1P33) WILD-TYPE 248 37

Figure S82.  Get High-res Image Gene #24: 'del_1p33' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_1p33' versus 'HISTOLOGICAL_TYPE'

P value = 0.0138 (Fisher's exact test), Q value = 0.075

Table S83.  Gene #24: 'del_1p33' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 2(1P33) MUTATED 113 9
DEL PEAK 2(1P33) WILD-TYPE 269 53

Figure S83.  Get High-res Image Gene #24: 'del_1p33' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_1p33' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00833 (Wilcoxon-test), Q value = 0.054

Table S84.  Gene #24: 'del_1p33' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 2(1P33) MUTATED 115 3.1 (6.4)
DEL PEAK 2(1P33) WILD-TYPE 309 1.7 (3.4)

Figure S84.  Get High-res Image Gene #24: 'del_1p33' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_1p13.1' versus 'PATHOLOGIC_STAGE'

P value = 0.00654 (Fisher's exact test), Q value = 0.046

Table S85.  Gene #25: 'del_1p13.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 3(1P13.1) MUTATED 12 0 5 32 1 0 5 3 15 14 24 3 0
DEL PEAK 3(1P13.1) WILD-TYPE 62 1 24 100 9 1 15 5 44 27 21 14 2

Figure S85.  Get High-res Image Gene #25: 'del_1p13.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_1p13.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00958 (Fisher's exact test), Q value = 0.059

Table S86.  Gene #25: 'del_1p13.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 3(1P13.1) MUTATED 56 31 31
DEL PEAK 3(1P13.1) WILD-TYPE 206 74 51

Figure S86.  Get High-res Image Gene #25: 'del_1p13.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_1p13.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.00306 (Fisher's exact test), Q value = 0.027

Table S87.  Gene #25: 'del_1p13.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 3(1P13.1) MUTATED 77 27
DEL PEAK 3(1P13.1) WILD-TYPE 251 37

Figure S87.  Get High-res Image Gene #25: 'del_1p13.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_1p13.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.045 (Fisher's exact test), Q value = 0.17

Table S88.  Gene #25: 'del_1p13.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 3(1P13.1) MUTATED 108 10
DEL PEAK 3(1P13.1) WILD-TYPE 274 52

Figure S88.  Get High-res Image Gene #25: 'del_1p13.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_1p13.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00107 (Wilcoxon-test), Q value = 0.013

Table S89.  Gene #25: 'del_1p13.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 3(1P13.1) MUTATED 108 3.0 (4.7)
DEL PEAK 3(1P13.1) WILD-TYPE 316 1.8 (4.3)

Figure S89.  Get High-res Image Gene #25: 'del_1p13.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_2q22.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00893 (Wilcoxon-test), Q value = 0.056

Table S90.  Gene #27: 'del_2q22.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 5(2Q22.1) MUTATED 22 2.9 (3.2)
DEL PEAK 5(2Q22.1) WILD-TYPE 402 2.0 (4.5)

Figure S90.  Get High-res Image Gene #27: 'del_2q22.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_2q22.1' versus 'RACE'

P value = 0.00605 (Fisher's exact test), Q value = 0.043

Table S91.  Gene #27: 'del_2q22.1' versus Clinical Feature #12: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN WHITE
ALL 1 11 59 212
DEL PEAK 5(2Q22.1) MUTATED 1 2 1 9
DEL PEAK 5(2Q22.1) WILD-TYPE 0 9 58 203

Figure S91.  Get High-res Image Gene #27: 'del_2q22.1' versus Clinical Feature #12: 'RACE'

'del_3p26.1' versus 'Time to Death'

P value = 0.0786 (logrank test), Q value = 0.25

Table S92.  Gene #28: 'del_3p26.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 6(3P26.1) MUTATED 70 17 0.2 - 85.0 (15.1)
DEL PEAK 6(3P26.1) WILD-TYPE 366 84 0.0 - 148.0 (23.7)

Figure S92.  Get High-res Image Gene #28: 'del_3p26.1' versus Clinical Feature #1: 'Time to Death'

'del_3p26.1' versus 'PATHOLOGIC_STAGE'

P value = 0.034 (Fisher's exact test), Q value = 0.14

Table S93.  Gene #28: 'del_3p26.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 6(3P26.1) MUTATED 6 0 2 19 0 0 3 2 11 7 16 4 0
DEL PEAK 6(3P26.1) WILD-TYPE 68 1 27 113 10 1 17 6 48 34 29 13 2

Figure S93.  Get High-res Image Gene #28: 'del_3p26.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_3p26.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00878 (Fisher's exact test), Q value = 0.056

Table S94.  Gene #28: 'del_3p26.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 6(3P26.1) MUTATED 30 22 19
DEL PEAK 6(3P26.1) WILD-TYPE 232 83 63

Figure S94.  Get High-res Image Gene #28: 'del_3p26.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_3p26.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.000589 (Fisher's exact test), Q value = 0.0087

Table S95.  Gene #28: 'del_3p26.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 6(3P26.1) MUTATED 42 20
DEL PEAK 6(3P26.1) WILD-TYPE 286 44

Figure S95.  Get High-res Image Gene #28: 'del_3p26.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_3p26.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.025 (Fisher's exact test), Q value = 0.11

Table S96.  Gene #28: 'del_3p26.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 6(3P26.1) MUTATED 67 4
DEL PEAK 6(3P26.1) WILD-TYPE 315 58

Figure S96.  Get High-res Image Gene #28: 'del_3p26.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_3p26.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0116 (Wilcoxon-test), Q value = 0.068

Table S97.  Gene #28: 'del_3p26.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 6(3P26.1) MUTATED 67 3.1 (5.7)
DEL PEAK 6(3P26.1) WILD-TYPE 357 1.9 (4.2)

Figure S97.  Get High-res Image Gene #28: 'del_3p26.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_3p14.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.0726 (Fisher's exact test), Q value = 0.24

Table S98.  Gene #29: 'del_3p14.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 7(3P14.2) MUTATED 42 23 22
DEL PEAK 7(3P14.2) WILD-TYPE 220 82 60

Figure S98.  Get High-res Image Gene #29: 'del_3p14.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_3p14.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.0533 (Fisher's exact test), Q value = 0.19

Table S99.  Gene #29: 'del_3p14.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 7(3P14.2) MUTATED 56 18
DEL PEAK 7(3P14.2) WILD-TYPE 272 46

Figure S99.  Get High-res Image Gene #29: 'del_3p14.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_3p14.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0248 (Wilcoxon-test), Q value = 0.11

Table S100.  Gene #29: 'del_3p14.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 7(3P14.2) MUTATED 83 3.3 (6.0)
DEL PEAK 7(3P14.2) WILD-TYPE 341 1.8 (3.9)

Figure S100.  Get High-res Image Gene #29: 'del_3p14.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_4p16.2' versus 'Time to Death'

P value = 0.0307 (logrank test), Q value = 0.13

Table S101.  Gene #31: 'del_4p16.2' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 9(4P16.2) MUTATED 133 37 0.2 - 91.8 (22.0)
DEL PEAK 9(4P16.2) WILD-TYPE 303 64 0.0 - 148.0 (22.1)

Figure S101.  Get High-res Image Gene #31: 'del_4p16.2' versus Clinical Feature #1: 'Time to Death'

'del_4p16.2' versus 'PATHOLOGIC_STAGE'

P value = 0.00063 (Fisher's exact test), Q value = 0.0089

Table S102.  Gene #31: 'del_4p16.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 9(4P16.2) MUTATED 16 0 7 33 3 0 4 5 16 17 27 7 0
DEL PEAK 9(4P16.2) WILD-TYPE 58 1 22 99 7 1 16 3 43 24 18 10 2

Figure S102.  Get High-res Image Gene #31: 'del_4p16.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_4p16.2' versus 'PATHOLOGY_N_STAGE'

P value = 8e-04 (Fisher's exact test), Q value = 0.01

Table S103.  Gene #31: 'del_4p16.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 9(4P16.2) MUTATED 63 39 36
DEL PEAK 9(4P16.2) WILD-TYPE 199 66 46

Figure S103.  Get High-res Image Gene #31: 'del_4p16.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_4p16.2' versus 'PATHOLOGY_M_STAGE'

P value = 4.25e-05 (Fisher's exact test), Q value = 0.0014

Table S104.  Gene #31: 'del_4p16.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 9(4P16.2) MUTATED 85 34
DEL PEAK 9(4P16.2) WILD-TYPE 243 30

Figure S104.  Get High-res Image Gene #31: 'del_4p16.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_4p16.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0173 (Fisher's exact test), Q value = 0.088

Table S105.  Gene #31: 'del_4p16.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 9(4P16.2) MUTATED 126 11
DEL PEAK 9(4P16.2) WILD-TYPE 256 51

Figure S105.  Get High-res Image Gene #31: 'del_4p16.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_4p16.2' versus 'RESIDUAL_TUMOR'

P value = 0.0791 (Fisher's exact test), Q value = 0.25

Table S106.  Gene #31: 'del_4p16.2' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 323 4 25 25
DEL PEAK 9(4P16.2) MUTATED 98 1 13 5
DEL PEAK 9(4P16.2) WILD-TYPE 225 3 12 20

Figure S106.  Get High-res Image Gene #31: 'del_4p16.2' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

'del_4p16.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00035 (Wilcoxon-test), Q value = 0.0066

Table S107.  Gene #31: 'del_4p16.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 9(4P16.2) MUTATED 132 2.9 (4.6)
DEL PEAK 9(4P16.2) WILD-TYPE 292 1.7 (4.3)

Figure S107.  Get High-res Image Gene #31: 'del_4p16.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_4p16.2' versus 'ETHNICITY'

P value = 0.077 (Fisher's exact test), Q value = 0.25

Table S108.  Gene #31: 'del_4p16.2' versus Clinical Feature #13: 'ETHNICITY'

nPatients HISPANIC OR LATINO NOT HISPANIC OR LATINO
ALL 4 269
DEL PEAK 9(4P16.2) MUTATED 3 77
DEL PEAK 9(4P16.2) WILD-TYPE 1 192

Figure S108.  Get High-res Image Gene #31: 'del_4p16.2' versus Clinical Feature #13: 'ETHNICITY'

'del_4q22.1' versus 'Time to Death'

P value = 0.0395 (logrank test), Q value = 0.16

Table S109.  Gene #32: 'del_4q22.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 10(4Q22.1) MUTATED 147 41 0.0 - 148.0 (21.9)
DEL PEAK 10(4Q22.1) WILD-TYPE 289 60 0.0 - 140.4 (22.1)

Figure S109.  Get High-res Image Gene #32: 'del_4q22.1' versus Clinical Feature #1: 'Time to Death'

'del_4q22.1' versus 'PATHOLOGIC_STAGE'

P value = 0.00979 (Fisher's exact test), Q value = 0.06

Table S110.  Gene #32: 'del_4q22.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 10(4Q22.1) MUTATED 14 0 8 40 3 0 4 5 23 20 22 6 1
DEL PEAK 10(4Q22.1) WILD-TYPE 60 1 21 92 7 1 16 3 36 21 23 11 1

Figure S110.  Get High-res Image Gene #32: 'del_4q22.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_4q22.1' versus 'PATHOLOGY_N_STAGE'

P value = 8e-04 (Fisher's exact test), Q value = 0.01

Table S111.  Gene #32: 'del_4q22.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 10(4Q22.1) MUTATED 69 44 37
DEL PEAK 10(4Q22.1) WILD-TYPE 193 61 45

Figure S111.  Get High-res Image Gene #32: 'del_4q22.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_4q22.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.0204 (Fisher's exact test), Q value = 0.099

Table S112.  Gene #32: 'del_4q22.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 10(4Q22.1) MUTATED 99 29
DEL PEAK 10(4Q22.1) WILD-TYPE 229 35

Figure S112.  Get High-res Image Gene #32: 'del_4q22.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_4q22.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.00374 (Fisher's exact test), Q value = 0.029

Table S113.  Gene #32: 'del_4q22.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 10(4Q22.1) MUTATED 138 11
DEL PEAK 10(4Q22.1) WILD-TYPE 244 51

Figure S113.  Get High-res Image Gene #32: 'del_4q22.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_4q22.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000307 (Wilcoxon-test), Q value = 0.0061

Table S114.  Gene #32: 'del_4q22.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 10(4Q22.1) MUTATED 142 2.8 (4.5)
DEL PEAK 10(4Q22.1) WILD-TYPE 282 1.7 (4.4)

Figure S114.  Get High-res Image Gene #32: 'del_4q22.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_4q35.1' versus 'PATHOLOGIC_STAGE'

P value = 0.0482 (Fisher's exact test), Q value = 0.18

Table S115.  Gene #33: 'del_4q35.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 11(4Q35.1) MUTATED 17 0 8 44 2 0 6 5 21 19 24 7 1
DEL PEAK 11(4Q35.1) WILD-TYPE 57 1 21 88 8 1 14 3 38 22 21 10 1

Figure S115.  Get High-res Image Gene #33: 'del_4q35.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_4q35.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00321 (Fisher's exact test), Q value = 0.027

Table S116.  Gene #33: 'del_4q35.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 11(4Q35.1) MUTATED 75 44 38
DEL PEAK 11(4Q35.1) WILD-TYPE 187 61 44

Figure S116.  Get High-res Image Gene #33: 'del_4q35.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_4q35.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.00998 (Fisher's exact test), Q value = 0.06

Table S117.  Gene #33: 'del_4q35.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 11(4Q35.1) MUTATED 107 32
DEL PEAK 11(4Q35.1) WILD-TYPE 221 32

Figure S117.  Get High-res Image Gene #33: 'del_4q35.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_4q35.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0623 (Fisher's exact test), Q value = 0.21

Table S118.  Gene #33: 'del_4q35.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 11(4Q35.1) MUTATED 140 15
DEL PEAK 11(4Q35.1) WILD-TYPE 242 47

Figure S118.  Get High-res Image Gene #33: 'del_4q35.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_4q35.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000771 (Wilcoxon-test), Q value = 0.01

Table S119.  Gene #33: 'del_4q35.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 11(4Q35.1) MUTATED 149 2.6 (4.3)
DEL PEAK 11(4Q35.1) WILD-TYPE 275 1.8 (4.5)

Figure S119.  Get High-res Image Gene #33: 'del_4q35.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_5q12.1' versus 'PATHOLOGIC_STAGE'

P value = 0.00355 (Fisher's exact test), Q value = 0.029

Table S120.  Gene #34: 'del_5q12.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 12(5Q12.1) MUTATED 17 0 5 19 1 0 3 5 14 16 13 8 1
DEL PEAK 12(5Q12.1) WILD-TYPE 57 1 24 113 9 1 17 3 45 25 32 9 1

Figure S120.  Get High-res Image Gene #34: 'del_5q12.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_5q12.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.0147 (Fisher's exact test), Q value = 0.079

Table S121.  Gene #34: 'del_5q12.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 12(5Q12.1) MUTATED 49 29 27
DEL PEAK 12(5Q12.1) WILD-TYPE 213 76 55

Figure S121.  Get High-res Image Gene #34: 'del_5q12.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_5q12.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.0216 (Fisher's exact test), Q value = 0.1

Table S122.  Gene #34: 'del_5q12.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 12(5Q12.1) MUTATED 67 22
DEL PEAK 12(5Q12.1) WILD-TYPE 261 42

Figure S122.  Get High-res Image Gene #34: 'del_5q12.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_5q12.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0356 (Fisher's exact test), Q value = 0.14

Table S123.  Gene #34: 'del_5q12.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 12(5Q12.1) MUTATED 97 8
DEL PEAK 12(5Q12.1) WILD-TYPE 285 54

Figure S123.  Get High-res Image Gene #34: 'del_5q12.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_5q12.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.006 (Wilcoxon-test), Q value = 0.043

Table S124.  Gene #34: 'del_5q12.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 12(5Q12.1) MUTATED 101 2.9 (5.0)
DEL PEAK 12(5Q12.1) WILD-TYPE 323 1.8 (4.2)

Figure S124.  Get High-res Image Gene #34: 'del_5q12.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_5q12.1' versus 'ETHNICITY'

P value = 0.051 (Fisher's exact test), Q value = 0.18

Table S125.  Gene #34: 'del_5q12.1' versus Clinical Feature #13: 'ETHNICITY'

nPatients HISPANIC OR LATINO NOT HISPANIC OR LATINO
ALL 4 269
DEL PEAK 12(5Q12.1) MUTATED 3 66
DEL PEAK 12(5Q12.1) WILD-TYPE 1 203

Figure S125.  Get High-res Image Gene #34: 'del_5q12.1' versus Clinical Feature #13: 'ETHNICITY'

'del_5q21.1' versus 'PATHOLOGIC_STAGE'

P value = 5e-05 (Fisher's exact test), Q value = 0.0015

Table S126.  Gene #35: 'del_5q21.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 13(5Q21.1) MUTATED 18 0 6 26 0 0 3 7 18 18 17 8 2
DEL PEAK 13(5Q21.1) WILD-TYPE 56 1 23 106 10 1 17 1 41 23 28 9 0

Figure S126.  Get High-res Image Gene #35: 'del_5q21.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_5q21.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00158 (Fisher's exact test), Q value = 0.016

Table S127.  Gene #35: 'del_5q21.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 13(5Q21.1) MUTATED 57 37 32
DEL PEAK 13(5Q21.1) WILD-TYPE 205 68 50

Figure S127.  Get High-res Image Gene #35: 'del_5q21.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_5q21.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.00895 (Fisher's exact test), Q value = 0.056

Table S128.  Gene #35: 'del_5q21.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 13(5Q21.1) MUTATED 82 27
DEL PEAK 13(5Q21.1) WILD-TYPE 246 37

Figure S128.  Get High-res Image Gene #35: 'del_5q21.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_5q21.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000501 (Wilcoxon-test), Q value = 0.008

Table S129.  Gene #35: 'del_5q21.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 13(5Q21.1) MUTATED 121 2.9 (4.9)
DEL PEAK 13(5Q21.1) WILD-TYPE 303 1.7 (4.2)

Figure S129.  Get High-res Image Gene #35: 'del_5q21.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_5q21.1' versus 'ETHNICITY'

P value = 0.077 (Fisher's exact test), Q value = 0.25

Table S130.  Gene #35: 'del_5q21.1' versus Clinical Feature #13: 'ETHNICITY'

nPatients HISPANIC OR LATINO NOT HISPANIC OR LATINO
ALL 4 269
DEL PEAK 13(5Q21.1) MUTATED 3 77
DEL PEAK 13(5Q21.1) WILD-TYPE 1 192

Figure S130.  Get High-res Image Gene #35: 'del_5q21.1' versus Clinical Feature #13: 'ETHNICITY'

'del_5q22.2' versus 'PATHOLOGIC_STAGE'

P value = 0.0045 (Fisher's exact test), Q value = 0.034

Table S131.  Gene #36: 'del_5q22.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 14(5Q22.2) MUTATED 19 0 7 29 0 0 4 6 16 16 19 8 1
DEL PEAK 14(5Q22.2) WILD-TYPE 55 1 22 103 10 1 16 2 43 25 26 9 1

Figure S131.  Get High-res Image Gene #36: 'del_5q22.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_5q22.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.0416 (Fisher's exact test), Q value = 0.16

Table S132.  Gene #36: 'del_5q22.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 14(5Q22.2) MUTATED 64 34 31
DEL PEAK 14(5Q22.2) WILD-TYPE 198 71 51

Figure S132.  Get High-res Image Gene #36: 'del_5q22.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_5q22.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.00342 (Fisher's exact test), Q value = 0.028

Table S133.  Gene #36: 'del_5q22.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 14(5Q22.2) MUTATED 81 28
DEL PEAK 14(5Q22.2) WILD-TYPE 247 36

Figure S133.  Get High-res Image Gene #36: 'del_5q22.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_5q22.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0182 (Wilcoxon-test), Q value = 0.091

Table S134.  Gene #36: 'del_5q22.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 14(5Q22.2) MUTATED 122 2.7 (4.8)
DEL PEAK 14(5Q22.2) WILD-TYPE 302 1.8 (4.3)

Figure S134.  Get High-res Image Gene #36: 'del_5q22.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_6p25.3' versus 'YEARS_TO_BIRTH'

P value = 0.0502 (Wilcoxon-test), Q value = 0.18

Table S135.  Gene #37: 'del_6p25.3' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 15(6P25.3) MUTATED 55 69.8 (12.7)
DEL PEAK 15(6P25.3) WILD-TYPE 392 66.5 (13.1)

Figure S135.  Get High-res Image Gene #37: 'del_6p25.3' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_6p25.3' versus 'GENDER'

P value = 0.0443 (Fisher's exact test), Q value = 0.17

Table S136.  Gene #37: 'del_6p25.3' versus Clinical Feature #7: 'GENDER'

nPatients FEMALE MALE
ALL 213 236
DEL PEAK 15(6P25.3) MUTATED 19 36
DEL PEAK 15(6P25.3) WILD-TYPE 194 200

Figure S136.  Get High-res Image Gene #37: 'del_6p25.3' versus Clinical Feature #7: 'GENDER'

'del_6p25.3' versus 'RACE'

P value = 0.0452 (Fisher's exact test), Q value = 0.17

Table S137.  Gene #37: 'del_6p25.3' versus Clinical Feature #12: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN WHITE
ALL 1 11 59 212
DEL PEAK 15(6P25.3) MUTATED 0 3 2 26
DEL PEAK 15(6P25.3) WILD-TYPE 1 8 57 186

Figure S137.  Get High-res Image Gene #37: 'del_6p25.3' versus Clinical Feature #12: 'RACE'

'del_6q26' versus 'Time to Death'

P value = 0.0238 (logrank test), Q value = 0.11

Table S138.  Gene #38: 'del_6q26' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 16(6Q26) MUTATED 59 19 0.2 - 131.5 (17.8)
DEL PEAK 16(6Q26) WILD-TYPE 377 82 0.0 - 148.0 (23.0)

Figure S138.  Get High-res Image Gene #38: 'del_6q26' versus Clinical Feature #1: 'Time to Death'

'del_6q26' versus 'PATHOLOGY_N_STAGE'

P value = 0.00272 (Fisher's exact test), Q value = 0.025

Table S139.  Gene #38: 'del_6q26' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 16(6Q26) MUTATED 26 14 21
DEL PEAK 16(6Q26) WILD-TYPE 236 91 61

Figure S139.  Get High-res Image Gene #38: 'del_6q26' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_6q26' versus 'PATHOLOGY_M_STAGE'

P value = 0.0264 (Fisher's exact test), Q value = 0.12

Table S140.  Gene #38: 'del_6q26' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 16(6Q26) MUTATED 37 14
DEL PEAK 16(6Q26) WILD-TYPE 291 50

Figure S140.  Get High-res Image Gene #38: 'del_6q26' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_6q26' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00099 (Wilcoxon-test), Q value = 0.012

Table S141.  Gene #38: 'del_6q26' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 16(6Q26) MUTATED 57 3.5 (4.6)
DEL PEAK 16(6Q26) WILD-TYPE 367 1.9 (4.4)

Figure S141.  Get High-res Image Gene #38: 'del_6q26' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_6q26' versus 'RACE'

P value = 0.0433 (Fisher's exact test), Q value = 0.17

Table S142.  Gene #38: 'del_6q26' versus Clinical Feature #12: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN WHITE
ALL 1 11 59 212
DEL PEAK 16(6Q26) MUTATED 1 3 5 26
DEL PEAK 16(6Q26) WILD-TYPE 0 8 54 186

Figure S142.  Get High-res Image Gene #38: 'del_6q26' versus Clinical Feature #12: 'RACE'

'del_7q31.1' versus 'ETHNICITY'

P value = 0.00699 (Fisher's exact test), Q value = 0.047

Table S143.  Gene #39: 'del_7q31.1' versus Clinical Feature #13: 'ETHNICITY'

nPatients HISPANIC OR LATINO NOT HISPANIC OR LATINO
ALL 4 269
DEL PEAK 17(7Q31.1) MUTATED 2 8
DEL PEAK 17(7Q31.1) WILD-TYPE 2 261

Figure S143.  Get High-res Image Gene #39: 'del_7q31.1' versus Clinical Feature #13: 'ETHNICITY'

'del_8p23.2' versus 'YEARS_TO_BIRTH'

P value = 0.0708 (Wilcoxon-test), Q value = 0.23

Table S144.  Gene #40: 'del_8p23.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 18(8P23.2) MUTATED 188 65.9 (12.1)
DEL PEAK 18(8P23.2) WILD-TYPE 259 67.7 (13.7)

Figure S144.  Get High-res Image Gene #40: 'del_8p23.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_8p23.2' versus 'PATHOLOGIC_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00039

Table S145.  Gene #40: 'del_8p23.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 18(8P23.2) MUTATED 24 0 9 39 2 0 8 4 28 26 31 11 1
DEL PEAK 18(8P23.2) WILD-TYPE 50 1 20 93 8 1 12 4 31 15 14 6 1

Figure S145.  Get High-res Image Gene #40: 'del_8p23.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_8p23.2' versus 'PATHOLOGY_N_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00039

Table S146.  Gene #40: 'del_8p23.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 18(8P23.2) MUTATED 85 52 51
DEL PEAK 18(8P23.2) WILD-TYPE 177 53 31

Figure S146.  Get High-res Image Gene #40: 'del_8p23.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_8p23.2' versus 'PATHOLOGY_M_STAGE'

P value = 2.5e-05 (Fisher's exact test), Q value = 0.00086

Table S147.  Gene #40: 'del_8p23.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 18(8P23.2) MUTATED 124 43
DEL PEAK 18(8P23.2) WILD-TYPE 204 21

Figure S147.  Get High-res Image Gene #40: 'del_8p23.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_8p23.2' versus 'GENDER'

P value = 0.0128 (Fisher's exact test), Q value = 0.071

Table S148.  Gene #40: 'del_8p23.2' versus Clinical Feature #7: 'GENDER'

nPatients FEMALE MALE
ALL 213 236
DEL PEAK 18(8P23.2) MUTATED 76 112
DEL PEAK 18(8P23.2) WILD-TYPE 137 124

Figure S148.  Get High-res Image Gene #40: 'del_8p23.2' versus Clinical Feature #7: 'GENDER'

'del_8p23.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.00328 (Fisher's exact test), Q value = 0.027

Table S149.  Gene #40: 'del_8p23.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 18(8P23.2) MUTATED 170 15
DEL PEAK 18(8P23.2) WILD-TYPE 212 47

Figure S149.  Get High-res Image Gene #40: 'del_8p23.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_8p23.2' versus 'RESIDUAL_TUMOR'

P value = 0.023 (Fisher's exact test), Q value = 0.11

Table S150.  Gene #40: 'del_8p23.2' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 323 4 25 25
DEL PEAK 18(8P23.2) MUTATED 127 2 16 6
DEL PEAK 18(8P23.2) WILD-TYPE 196 2 9 19

Figure S150.  Get High-res Image Gene #40: 'del_8p23.2' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

'del_8p23.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 4.13e-06 (Wilcoxon-test), Q value = 0.00025

Table S151.  Gene #40: 'del_8p23.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 18(8P23.2) MUTATED 182 3.0 (5.5)
DEL PEAK 18(8P23.2) WILD-TYPE 242 1.4 (3.3)

Figure S151.  Get High-res Image Gene #40: 'del_8p23.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_8p22' versus 'Time to Death'

P value = 0.0489 (logrank test), Q value = 0.18

Table S152.  Gene #41: 'del_8p22' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 19(8P22) MUTATED 199 55 0.0 - 148.0 (24.0)
DEL PEAK 19(8P22) WILD-TYPE 237 46 0.0 - 139.2 (21.1)

Figure S152.  Get High-res Image Gene #41: 'del_8p22' versus Clinical Feature #1: 'Time to Death'

'del_8p22' versus 'YEARS_TO_BIRTH'

P value = 0.0262 (Wilcoxon-test), Q value = 0.12

Table S153.  Gene #41: 'del_8p22' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 19(8P22) MUTATED 201 65.7 (12.2)
DEL PEAK 19(8P22) WILD-TYPE 246 67.9 (13.7)

Figure S153.  Get High-res Image Gene #41: 'del_8p22' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_8p22' versus 'PATHOLOGIC_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00039

Table S154.  Gene #41: 'del_8p22' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 19(8P22) MUTATED 25 0 10 41 2 0 9 5 31 27 31 14 1
DEL PEAK 19(8P22) WILD-TYPE 49 1 19 91 8 1 11 3 28 14 14 3 1

Figure S154.  Get High-res Image Gene #41: 'del_8p22' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_8p22' versus 'PATHOLOGY_T_STAGE'

P value = 0.0485 (Fisher's exact test), Q value = 0.18

Table S155.  Gene #41: 'del_8p22' versus Clinical Feature #4: 'PATHOLOGY_T_STAGE'

nPatients T1 T2 T3 T4
ALL 11 77 305 55
DEL PEAK 19(8P22) MUTATED 1 30 144 26
DEL PEAK 19(8P22) WILD-TYPE 10 47 161 29

Figure S155.  Get High-res Image Gene #41: 'del_8p22' versus Clinical Feature #4: 'PATHOLOGY_T_STAGE'

'del_8p22' versus 'PATHOLOGY_N_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00039

Table S156.  Gene #41: 'del_8p22' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 19(8P22) MUTATED 90 56 55
DEL PEAK 19(8P22) WILD-TYPE 172 49 27

Figure S156.  Get High-res Image Gene #41: 'del_8p22' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_8p22' versus 'PATHOLOGY_M_STAGE'

P value = 4.51e-06 (Fisher's exact test), Q value = 0.00026

Table S157.  Gene #41: 'del_8p22' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 19(8P22) MUTATED 133 46
DEL PEAK 19(8P22) WILD-TYPE 195 18

Figure S157.  Get High-res Image Gene #41: 'del_8p22' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_8p22' versus 'GENDER'

P value = 0.0573 (Fisher's exact test), Q value = 0.2

Table S158.  Gene #41: 'del_8p22' versus Clinical Feature #7: 'GENDER'

nPatients FEMALE MALE
ALL 213 236
DEL PEAK 19(8P22) MUTATED 85 116
DEL PEAK 19(8P22) WILD-TYPE 128 120

Figure S158.  Get High-res Image Gene #41: 'del_8p22' versus Clinical Feature #7: 'GENDER'

'del_8p22' versus 'HISTOLOGICAL_TYPE'

P value = 0.00142 (Fisher's exact test), Q value = 0.015

Table S159.  Gene #41: 'del_8p22' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 19(8P22) MUTATED 182 16
DEL PEAK 19(8P22) WILD-TYPE 200 46

Figure S159.  Get High-res Image Gene #41: 'del_8p22' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_8p22' versus 'RESIDUAL_TUMOR'

P value = 0.0307 (Fisher's exact test), Q value = 0.13

Table S160.  Gene #41: 'del_8p22' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 323 4 25 25
DEL PEAK 19(8P22) MUTATED 139 2 16 6
DEL PEAK 19(8P22) WILD-TYPE 184 2 9 19

Figure S160.  Get High-res Image Gene #41: 'del_8p22' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

'del_8p22' versus 'NUMBER_OF_LYMPH_NODES'

P value = 3.44e-07 (Wilcoxon-test), Q value = 2.5e-05

Table S161.  Gene #41: 'del_8p22' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 19(8P22) MUTATED 195 2.9 (5.4)
DEL PEAK 19(8P22) WILD-TYPE 229 1.3 (3.3)

Figure S161.  Get High-res Image Gene #41: 'del_8p22' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_8q11.1' versus 'RACE'

P value = 0.0545 (Fisher's exact test), Q value = 0.19

Table S162.  Gene #42: 'del_8q11.1' versus Clinical Feature #12: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN WHITE
ALL 1 11 59 212
DEL PEAK 20(8Q11.1) MUTATED 1 0 6 13
DEL PEAK 20(8Q11.1) WILD-TYPE 0 11 53 199

Figure S162.  Get High-res Image Gene #42: 'del_8q11.1' versus Clinical Feature #12: 'RACE'

'del_9p21.3' versus 'YEARS_TO_BIRTH'

P value = 0.0761 (Wilcoxon-test), Q value = 0.25

Table S163.  Gene #43: 'del_9p21.3' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 21(9P21.3) MUTATED 61 64.3 (12.8)
DEL PEAK 21(9P21.3) WILD-TYPE 386 67.3 (13.1)

Figure S163.  Get High-res Image Gene #43: 'del_9p21.3' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_9p21.3' versus 'HISTOLOGICAL_TYPE'

P value = 0.00824 (Fisher's exact test), Q value = 0.054

Table S164.  Gene #43: 'del_9p21.3' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 21(9P21.3) MUTATED 58 2
DEL PEAK 21(9P21.3) WILD-TYPE 324 60

Figure S164.  Get High-res Image Gene #43: 'del_9p21.3' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_10p15.3' versus 'PATHOLOGIC_STAGE'

P value = 0.00115 (Fisher's exact test), Q value = 0.013

Table S165.  Gene #44: 'del_10p15.3' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 22(10P15.3) MUTATED 10 0 7 12 1 1 1 3 12 8 16 4 1
DEL PEAK 22(10P15.3) WILD-TYPE 64 1 22 120 9 0 19 5 47 33 29 13 1

Figure S165.  Get High-res Image Gene #44: 'del_10p15.3' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_10p15.3' versus 'PATHOLOGY_N_STAGE'

P value = 0.011 (Fisher's exact test), Q value = 0.064

Table S166.  Gene #44: 'del_10p15.3' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 22(10P15.3) MUTATED 34 23 21
DEL PEAK 22(10P15.3) WILD-TYPE 228 82 61

Figure S166.  Get High-res Image Gene #44: 'del_10p15.3' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_10p15.3' versus 'PATHOLOGY_M_STAGE'

P value = 0.00106 (Fisher's exact test), Q value = 0.013

Table S167.  Gene #44: 'del_10p15.3' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 22(10P15.3) MUTATED 48 21
DEL PEAK 22(10P15.3) WILD-TYPE 280 43

Figure S167.  Get High-res Image Gene #44: 'del_10p15.3' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_10p15.3' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00361 (Wilcoxon-test), Q value = 0.029

Table S168.  Gene #44: 'del_10p15.3' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 22(10P15.3) MUTATED 75 3.1 (6.4)
DEL PEAK 22(10P15.3) WILD-TYPE 349 1.9 (3.9)

Figure S168.  Get High-res Image Gene #44: 'del_10p15.3' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_10q21.1' versus 'YEARS_TO_BIRTH'

P value = 0.0433 (Wilcoxon-test), Q value = 0.17

Table S169.  Gene #45: 'del_10q21.1' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 23(10Q21.1) MUTATED 97 64.4 (13.3)
DEL PEAK 23(10Q21.1) WILD-TYPE 350 67.6 (12.9)

Figure S169.  Get High-res Image Gene #45: 'del_10q21.1' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_10q21.1' versus 'PATHOLOGIC_STAGE'

P value = 0.00644 (Fisher's exact test), Q value = 0.045

Table S170.  Gene #45: 'del_10q21.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 23(10Q21.1) MUTATED 12 0 7 19 1 1 1 2 14 14 17 5 1
DEL PEAK 23(10Q21.1) WILD-TYPE 62 1 22 113 9 0 19 6 45 27 28 12 1

Figure S170.  Get High-res Image Gene #45: 'del_10q21.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_10q21.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.0211 (Fisher's exact test), Q value = 0.1

Table S171.  Gene #45: 'del_10q21.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 23(10Q21.1) MUTATED 46 25 26
DEL PEAK 23(10Q21.1) WILD-TYPE 216 80 56

Figure S171.  Get High-res Image Gene #45: 'del_10q21.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_10q21.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.00478 (Fisher's exact test), Q value = 0.036

Table S172.  Gene #45: 'del_10q21.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 23(10Q21.1) MUTATED 63 23
DEL PEAK 23(10Q21.1) WILD-TYPE 265 41

Figure S172.  Get High-res Image Gene #45: 'del_10q21.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_10q21.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.031 (Fisher's exact test), Q value = 0.13

Table S173.  Gene #45: 'del_10q21.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 23(10Q21.1) MUTATED 90 7
DEL PEAK 23(10Q21.1) WILD-TYPE 292 55

Figure S173.  Get High-res Image Gene #45: 'del_10q21.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_10q21.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.01 (Wilcoxon-test), Q value = 0.06

Table S174.  Gene #45: 'del_10q21.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 23(10Q21.1) MUTATED 93 2.9 (6.1)
DEL PEAK 23(10Q21.1) WILD-TYPE 331 1.9 (3.8)

Figure S174.  Get High-res Image Gene #45: 'del_10q21.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_10q21.1' versus 'ETHNICITY'

P value = 0.0413 (Fisher's exact test), Q value = 0.16

Table S175.  Gene #45: 'del_10q21.1' versus Clinical Feature #13: 'ETHNICITY'

nPatients HISPANIC OR LATINO NOT HISPANIC OR LATINO
ALL 4 269
DEL PEAK 23(10Q21.1) MUTATED 3 61
DEL PEAK 23(10Q21.1) WILD-TYPE 1 208

Figure S175.  Get High-res Image Gene #45: 'del_10q21.1' versus Clinical Feature #13: 'ETHNICITY'

'del_10q23.31' versus 'YEARS_TO_BIRTH'

P value = 0.00317 (Wilcoxon-test), Q value = 0.027

Table S176.  Gene #46: 'del_10q23.31' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 24(10Q23.31) MUTATED 108 63.7 (13.1)
DEL PEAK 24(10Q23.31) WILD-TYPE 339 67.9 (12.9)

Figure S176.  Get High-res Image Gene #46: 'del_10q23.31' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_10q23.31' versus 'PATHOLOGIC_STAGE'

P value = 0.0122 (Fisher's exact test), Q value = 0.07

Table S177.  Gene #46: 'del_10q23.31' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 24(10Q23.31) MUTATED 14 1 7 24 1 1 3 4 14 12 17 5 2
DEL PEAK 24(10Q23.31) WILD-TYPE 60 0 22 108 9 0 17 4 45 29 28 12 0

Figure S177.  Get High-res Image Gene #46: 'del_10q23.31' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_10q23.31' versus 'PATHOLOGY_N_STAGE'

P value = 0.04 (Fisher's exact test), Q value = 0.16

Table S178.  Gene #46: 'del_10q23.31' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 24(10Q23.31) MUTATED 52 30 26
DEL PEAK 24(10Q23.31) WILD-TYPE 210 75 56

Figure S178.  Get High-res Image Gene #46: 'del_10q23.31' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_10q23.31' versus 'PATHOLOGY_M_STAGE'

P value = 0.0167 (Fisher's exact test), Q value = 0.086

Table S179.  Gene #46: 'del_10q23.31' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 24(10Q23.31) MUTATED 73 24
DEL PEAK 24(10Q23.31) WILD-TYPE 255 40

Figure S179.  Get High-res Image Gene #46: 'del_10q23.31' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_10q23.31' versus 'HISTOLOGICAL_TYPE'

P value = 0.0765 (Fisher's exact test), Q value = 0.25

Table S180.  Gene #46: 'del_10q23.31' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 24(10Q23.31) MUTATED 97 9
DEL PEAK 24(10Q23.31) WILD-TYPE 285 53

Figure S180.  Get High-res Image Gene #46: 'del_10q23.31' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_10q23.31' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00894 (Wilcoxon-test), Q value = 0.056

Table S181.  Gene #46: 'del_10q23.31' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 24(10Q23.31) MUTATED 104 2.4 (3.8)
DEL PEAK 24(10Q23.31) WILD-TYPE 320 2.0 (4.6)

Figure S181.  Get High-res Image Gene #46: 'del_10q23.31' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_10q25.2' versus 'YEARS_TO_BIRTH'

P value = 0.0582 (Wilcoxon-test), Q value = 0.2

Table S182.  Gene #47: 'del_10q25.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 25(10Q25.2) MUTATED 108 64.9 (13.0)
DEL PEAK 25(10Q25.2) WILD-TYPE 339 67.6 (13.0)

Figure S182.  Get High-res Image Gene #47: 'del_10q25.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_10q25.2' versus 'PATHOLOGIC_STAGE'

P value = 0.0662 (Fisher's exact test), Q value = 0.22

Table S183.  Gene #47: 'del_10q25.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 25(10Q25.2) MUTATED 11 0 8 26 1 1 5 3 14 13 18 5 1
DEL PEAK 25(10Q25.2) WILD-TYPE 63 1 21 106 9 0 15 5 45 28 27 12 1

Figure S183.  Get High-res Image Gene #47: 'del_10q25.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_10q25.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.0125 (Fisher's exact test), Q value = 0.071

Table S184.  Gene #47: 'del_10q25.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 25(10Q25.2) MUTATED 50 31 27
DEL PEAK 25(10Q25.2) WILD-TYPE 212 74 55

Figure S184.  Get High-res Image Gene #47: 'del_10q25.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_10q25.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.018 (Fisher's exact test), Q value = 0.09

Table S185.  Gene #47: 'del_10q25.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 25(10Q25.2) MUTATED 75 24
DEL PEAK 25(10Q25.2) WILD-TYPE 253 40

Figure S185.  Get High-res Image Gene #47: 'del_10q25.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_10q25.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.077 (Fisher's exact test), Q value = 0.25

Table S186.  Gene #47: 'del_10q25.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 25(10Q25.2) MUTATED 98 9
DEL PEAK 25(10Q25.2) WILD-TYPE 284 53

Figure S186.  Get High-res Image Gene #47: 'del_10q25.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_10q25.2' versus 'RESIDUAL_TUMOR'

P value = 0.0563 (Fisher's exact test), Q value = 0.19

Table S187.  Gene #47: 'del_10q25.2' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 323 4 25 25
DEL PEAK 25(10Q25.2) MUTATED 74 2 11 5
DEL PEAK 25(10Q25.2) WILD-TYPE 249 2 14 20

Figure S187.  Get High-res Image Gene #47: 'del_10q25.2' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

'del_10q25.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00666 (Wilcoxon-test), Q value = 0.046

Table S188.  Gene #47: 'del_10q25.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 25(10Q25.2) MUTATED 104 2.5 (3.9)
DEL PEAK 25(10Q25.2) WILD-TYPE 320 1.9 (4.6)

Figure S188.  Get High-res Image Gene #47: 'del_10q25.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_12p13.2' versus 'Time to Death'

P value = 0.047 (logrank test), Q value = 0.18

Table S189.  Gene #48: 'del_12p13.2' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 26(12P13.2) MUTATED 60 19 2.0 - 78.1 (19.6)
DEL PEAK 26(12P13.2) WILD-TYPE 376 82 0.0 - 148.0 (22.1)

Figure S189.  Get High-res Image Gene #48: 'del_12p13.2' versus Clinical Feature #1: 'Time to Death'

'del_12p13.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.0712 (Fisher's exact test), Q value = 0.23

Table S190.  Gene #48: 'del_12p13.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 26(12P13.2) MUTATED 27 19 14
DEL PEAK 26(12P13.2) WILD-TYPE 235 86 68

Figure S190.  Get High-res Image Gene #48: 'del_12p13.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_12p13.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.0601 (Fisher's exact test), Q value = 0.2

Table S191.  Gene #48: 'del_12p13.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 26(12P13.2) MUTATED 36 13
DEL PEAK 26(12P13.2) WILD-TYPE 292 51

Figure S191.  Get High-res Image Gene #48: 'del_12p13.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_12p13.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.00825 (Fisher's exact test), Q value = 0.054

Table S192.  Gene #48: 'del_12p13.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 26(12P13.2) MUTATED 57 2
DEL PEAK 26(12P13.2) WILD-TYPE 325 60

Figure S192.  Get High-res Image Gene #48: 'del_12p13.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_12p13.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.075 (Wilcoxon-test), Q value = 0.25

Table S193.  Gene #48: 'del_12p13.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 26(12P13.2) MUTATED 57 2.2 (3.4)
DEL PEAK 26(12P13.2) WILD-TYPE 367 2.1 (4.6)

Figure S193.  Get High-res Image Gene #48: 'del_12p13.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_13q14.13' versus 'PATHOLOGY_N_STAGE'

P value = 0.0366 (Fisher's exact test), Q value = 0.15

Table S194.  Gene #49: 'del_13q14.13' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 27(13Q14.13) MUTATED 11 1 7
DEL PEAK 27(13Q14.13) WILD-TYPE 251 104 75

Figure S194.  Get High-res Image Gene #49: 'del_13q14.13' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_13q14.13' versus 'RACE'

P value = 0.0314 (Fisher's exact test), Q value = 0.13

Table S195.  Gene #49: 'del_13q14.13' versus Clinical Feature #12: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN WHITE
ALL 1 11 59 212
DEL PEAK 27(13Q14.13) MUTATED 1 1 3 8
DEL PEAK 27(13Q14.13) WILD-TYPE 0 10 56 204

Figure S195.  Get High-res Image Gene #49: 'del_13q14.13' versus Clinical Feature #12: 'RACE'

'del_14q31.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.031 (Fisher's exact test), Q value = 0.13

Table S196.  Gene #50: 'del_14q31.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 28(14Q31.1) MUTATED 74 42 33
DEL PEAK 28(14Q31.1) WILD-TYPE 188 63 49

Figure S196.  Get High-res Image Gene #50: 'del_14q31.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_14q31.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.00929 (Fisher's exact test), Q value = 0.058

Table S197.  Gene #50: 'del_14q31.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 28(14Q31.1) MUTATED 102 31
DEL PEAK 28(14Q31.1) WILD-TYPE 226 33

Figure S197.  Get High-res Image Gene #50: 'del_14q31.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_14q31.1' versus 'HISTOLOGICAL_TYPE'

P value = 3.01e-07 (Fisher's exact test), Q value = 2.5e-05

Table S198.  Gene #50: 'del_14q31.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 28(14Q31.1) MUTATED 141 4
DEL PEAK 28(14Q31.1) WILD-TYPE 241 58

Figure S198.  Get High-res Image Gene #50: 'del_14q31.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_14q31.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0126 (Wilcoxon-test), Q value = 0.071

Table S199.  Gene #50: 'del_14q31.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 28(14Q31.1) MUTATED 141 2.6 (4.8)
DEL PEAK 28(14Q31.1) WILD-TYPE 283 1.8 (4.2)

Figure S199.  Get High-res Image Gene #50: 'del_14q31.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_15q11.2' versus 'PATHOLOGIC_STAGE'

P value = 0.0295 (Fisher's exact test), Q value = 0.13

Table S200.  Gene #51: 'del_15q11.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 29(15Q11.2) MUTATED 28 0 8 42 2 0 6 5 23 20 23 11 2
DEL PEAK 29(15Q11.2) WILD-TYPE 46 1 21 90 8 1 14 3 36 21 22 6 0

Figure S200.  Get High-res Image Gene #51: 'del_15q11.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_15q11.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.015 (Fisher's exact test), Q value = 0.08

Table S201.  Gene #51: 'del_15q11.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 29(15Q11.2) MUTATED 88 49 39
DEL PEAK 29(15Q11.2) WILD-TYPE 174 56 43

Figure S201.  Get High-res Image Gene #51: 'del_15q11.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_15q11.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.00316 (Fisher's exact test), Q value = 0.027

Table S202.  Gene #51: 'del_15q11.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 29(15Q11.2) MUTATED 118 36
DEL PEAK 29(15Q11.2) WILD-TYPE 210 28

Figure S202.  Get High-res Image Gene #51: 'del_15q11.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_15q11.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0245 (Fisher's exact test), Q value = 0.11

Table S203.  Gene #51: 'del_15q11.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 29(15Q11.2) MUTATED 157 16
DEL PEAK 29(15Q11.2) WILD-TYPE 225 46

Figure S203.  Get High-res Image Gene #51: 'del_15q11.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_15q11.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00748 (Wilcoxon-test), Q value = 0.05

Table S204.  Gene #51: 'del_15q11.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 29(15Q11.2) MUTATED 167 2.4 (3.8)
DEL PEAK 29(15Q11.2) WILD-TYPE 257 1.9 (4.8)

Figure S204.  Get High-res Image Gene #51: 'del_15q11.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_15q15.2' versus 'PATHOLOGIC_STAGE'

P value = 0.0252 (Fisher's exact test), Q value = 0.11

Table S205.  Gene #52: 'del_15q15.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 30(15Q15.2) MUTATED 29 0 8 39 2 0 6 4 22 19 25 10 2
DEL PEAK 30(15Q15.2) WILD-TYPE 45 1 21 93 8 1 14 4 37 22 20 7 0

Figure S205.  Get High-res Image Gene #52: 'del_15q15.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_15q15.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.013 (Fisher's exact test), Q value = 0.072

Table S206.  Gene #52: 'del_15q15.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 30(15Q15.2) MUTATED 85 50 36
DEL PEAK 30(15Q15.2) WILD-TYPE 177 55 46

Figure S206.  Get High-res Image Gene #52: 'del_15q15.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_15q15.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.00037 (Fisher's exact test), Q value = 0.0066

Table S207.  Gene #52: 'del_15q15.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 30(15Q15.2) MUTATED 110 37
DEL PEAK 30(15Q15.2) WILD-TYPE 218 27

Figure S207.  Get High-res Image Gene #52: 'del_15q15.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_15q15.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0167 (Fisher's exact test), Q value = 0.086

Table S208.  Gene #52: 'del_15q15.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 30(15Q15.2) MUTATED 153 15
DEL PEAK 30(15Q15.2) WILD-TYPE 229 47

Figure S208.  Get High-res Image Gene #52: 'del_15q15.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_15q15.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0137 (Wilcoxon-test), Q value = 0.075

Table S209.  Gene #52: 'del_15q15.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 30(15Q15.2) MUTATED 163 2.3 (3.8)
DEL PEAK 30(15Q15.2) WILD-TYPE 261 2.0 (4.8)

Figure S209.  Get High-res Image Gene #52: 'del_15q15.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_15q21.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.0551 (Fisher's exact test), Q value = 0.19

Table S210.  Gene #53: 'del_15q21.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 31(15Q21.1) MUTATED 86 47 35
DEL PEAK 31(15Q21.1) WILD-TYPE 176 58 47

Figure S210.  Get High-res Image Gene #53: 'del_15q21.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_15q21.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.000651 (Fisher's exact test), Q value = 0.009

Table S211.  Gene #53: 'del_15q21.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 31(15Q21.1) MUTATED 109 36
DEL PEAK 31(15Q21.1) WILD-TYPE 219 28

Figure S211.  Get High-res Image Gene #53: 'del_15q21.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_15q21.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0233 (Fisher's exact test), Q value = 0.11

Table S212.  Gene #53: 'del_15q21.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 31(15Q21.1) MUTATED 151 15
DEL PEAK 31(15Q21.1) WILD-TYPE 231 47

Figure S212.  Get High-res Image Gene #53: 'del_15q21.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_15q21.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0482 (Wilcoxon-test), Q value = 0.18

Table S213.  Gene #53: 'del_15q21.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 31(15Q21.1) MUTATED 160 2.3 (3.8)
DEL PEAK 31(15Q21.1) WILD-TYPE 264 2.0 (4.8)

Figure S213.  Get High-res Image Gene #53: 'del_15q21.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_15q22.33' versus 'PATHOLOGIC_STAGE'

P value = 0.0203 (Fisher's exact test), Q value = 0.099

Table S214.  Gene #54: 'del_15q22.33' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 32(15Q22.33) MUTATED 23 0 7 39 2 0 5 4 19 20 23 11 1
DEL PEAK 32(15Q22.33) WILD-TYPE 51 1 22 93 8 1 15 4 40 21 22 6 1

Figure S214.  Get High-res Image Gene #54: 'del_15q22.33' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_15q22.33' versus 'PATHOLOGY_N_STAGE'

P value = 0.0156 (Fisher's exact test), Q value = 0.083

Table S215.  Gene #54: 'del_15q22.33' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 32(15Q22.33) MUTATED 79 44 37
DEL PEAK 32(15Q22.33) WILD-TYPE 183 61 45

Figure S215.  Get High-res Image Gene #54: 'del_15q22.33' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_15q22.33' versus 'PATHOLOGY_M_STAGE'

P value = 0.000507 (Fisher's exact test), Q value = 0.008

Table S216.  Gene #54: 'del_15q22.33' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 32(15Q22.33) MUTATED 102 35
DEL PEAK 32(15Q22.33) WILD-TYPE 226 29

Figure S216.  Get High-res Image Gene #54: 'del_15q22.33' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_15q22.33' versus 'HISTOLOGICAL_TYPE'

P value = 0.0226 (Fisher's exact test), Q value = 0.11

Table S217.  Gene #54: 'del_15q22.33' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 32(15Q22.33) MUTATED 143 14
DEL PEAK 32(15Q22.33) WILD-TYPE 239 48

Figure S217.  Get High-res Image Gene #54: 'del_15q22.33' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_15q22.33' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00948 (Wilcoxon-test), Q value = 0.059

Table S218.  Gene #54: 'del_15q22.33' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 32(15Q22.33) MUTATED 152 2.3 (3.8)
DEL PEAK 32(15Q22.33) WILD-TYPE 272 1.9 (4.8)

Figure S218.  Get High-res Image Gene #54: 'del_15q22.33' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_16p13.3' versus 'Time to Death'

P value = 0.00451 (logrank test), Q value = 0.034

Table S219.  Gene #55: 'del_16p13.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 33(16P13.3) MUTATED 54 19 0.2 - 61.8 (19.2)
DEL PEAK 33(16P13.3) WILD-TYPE 382 82 0.0 - 148.0 (22.2)

Figure S219.  Get High-res Image Gene #55: 'del_16p13.3' versus Clinical Feature #1: 'Time to Death'

'del_16p13.3' versus 'PATHOLOGIC_STAGE'

P value = 0.0332 (Fisher's exact test), Q value = 0.14

Table S220.  Gene #55: 'del_16p13.3' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 33(16P13.3) MUTATED 3 0 3 17 3 0 0 0 9 9 6 5 0
DEL PEAK 33(16P13.3) WILD-TYPE 71 1 26 115 7 1 20 8 50 32 39 12 2

Figure S220.  Get High-res Image Gene #55: 'del_16p13.3' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_16p13.3' versus 'PATHOLOGY_T_STAGE'

P value = 0.0293 (Fisher's exact test), Q value = 0.13

Table S221.  Gene #55: 'del_16p13.3' versus Clinical Feature #4: 'PATHOLOGY_T_STAGE'

nPatients T1 T2 T3 T4
ALL 11 77 305 55
DEL PEAK 33(16P13.3) MUTATED 0 3 45 8
DEL PEAK 33(16P13.3) WILD-TYPE 11 74 260 47

Figure S221.  Get High-res Image Gene #55: 'del_16p13.3' versus Clinical Feature #4: 'PATHOLOGY_T_STAGE'

'del_16q23.1' versus 'Time to Death'

P value = 0.0176 (logrank test), Q value = 0.089

Table S222.  Gene #56: 'del_16q23.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 34(16Q23.1) MUTATED 59 17 0.9 - 53.0 (18.1)
DEL PEAK 34(16Q23.1) WILD-TYPE 377 84 0.0 - 148.0 (23.5)

Figure S222.  Get High-res Image Gene #56: 'del_16q23.1' versus Clinical Feature #1: 'Time to Death'

'del_17p12' versus 'YEARS_TO_BIRTH'

P value = 0.0249 (Wilcoxon-test), Q value = 0.11

Table S223.  Gene #57: 'del_17p12' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 35(17P12) MUTATED 252 65.8 (12.6)
DEL PEAK 35(17P12) WILD-TYPE 195 68.3 (13.6)

Figure S223.  Get High-res Image Gene #57: 'del_17p12' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_17p12' versus 'PATHOLOGIC_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00039

Table S224.  Gene #57: 'del_17p12' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 35(17P12) MUTATED 36 0 14 56 2 1 12 8 35 31 34 13 2
DEL PEAK 35(17P12) WILD-TYPE 38 1 15 76 8 0 8 0 24 10 11 4 0

Figure S224.  Get High-res Image Gene #57: 'del_17p12' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_17p12' versus 'PATHOLOGY_N_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00039

Table S225.  Gene #57: 'del_17p12' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 35(17P12) MUTATED 122 71 59
DEL PEAK 35(17P12) WILD-TYPE 140 34 23

Figure S225.  Get High-res Image Gene #57: 'del_17p12' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_17p12' versus 'PATHOLOGY_M_STAGE'

P value = 0.000496 (Fisher's exact test), Q value = 0.008

Table S226.  Gene #57: 'del_17p12' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 35(17P12) MUTATED 173 49
DEL PEAK 35(17P12) WILD-TYPE 155 15

Figure S226.  Get High-res Image Gene #57: 'del_17p12' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_17p12' versus 'HISTOLOGICAL_TYPE'

P value = 3.56e-07 (Fisher's exact test), Q value = 2.5e-05

Table S227.  Gene #57: 'del_17p12' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 35(17P12) MUTATED 232 16
DEL PEAK 35(17P12) WILD-TYPE 150 46

Figure S227.  Get High-res Image Gene #57: 'del_17p12' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_17p12' versus 'NUMBER_OF_LYMPH_NODES'

P value = 1.94e-06 (Wilcoxon-test), Q value = 0.00013

Table S228.  Gene #57: 'del_17p12' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 35(17P12) MUTATED 238 2.8 (5.4)
DEL PEAK 35(17P12) WILD-TYPE 186 1.2 (2.6)

Figure S228.  Get High-res Image Gene #57: 'del_17p12' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_17q24.3' versus 'Time to Death'

P value = 0.0711 (logrank test), Q value = 0.23

Table S229.  Gene #58: 'del_17q24.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 436 101 0.0 - 148.0 (22.0)
DEL PEAK 36(17Q24.3) MUTATED 68 21 0.2 - 140.4 (23.3)
DEL PEAK 36(17Q24.3) WILD-TYPE 368 80 0.0 - 148.0 (22.0)

Figure S229.  Get High-res Image Gene #58: 'del_17q24.3' versus Clinical Feature #1: 'Time to Death'

'del_17q24.3' versus 'PATHOLOGIC_STAGE'

P value = 0.00308 (Fisher's exact test), Q value = 0.027

Table S230.  Gene #58: 'del_17q24.3' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 36(17Q24.3) MUTATED 10 0 4 10 0 0 3 2 7 12 10 7 1
DEL PEAK 36(17Q24.3) WILD-TYPE 64 1 25 122 10 1 17 6 52 29 35 10 1

Figure S230.  Get High-res Image Gene #58: 'del_17q24.3' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_17q24.3' versus 'PATHOLOGY_N_STAGE'

P value = 0.0019 (Fisher's exact test), Q value = 0.019

Table S231.  Gene #58: 'del_17q24.3' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 36(17Q24.3) MUTATED 27 23 19
DEL PEAK 36(17Q24.3) WILD-TYPE 235 82 63

Figure S231.  Get High-res Image Gene #58: 'del_17q24.3' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_17q24.3' versus 'PATHOLOGY_M_STAGE'

P value = 0.00317 (Fisher's exact test), Q value = 0.027

Table S232.  Gene #58: 'del_17q24.3' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 36(17Q24.3) MUTATED 40 18
DEL PEAK 36(17Q24.3) WILD-TYPE 288 46

Figure S232.  Get High-res Image Gene #58: 'del_17q24.3' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_17q24.3' versus 'NUMBER_OF_LYMPH_NODES'

P value = 7.89e-05 (Wilcoxon-test), Q value = 0.0021

Table S233.  Gene #58: 'del_17q24.3' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 36(17Q24.3) MUTATED 65 3.0 (3.9)
DEL PEAK 36(17Q24.3) WILD-TYPE 359 1.9 (4.5)

Figure S233.  Get High-res Image Gene #58: 'del_17q24.3' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_18p11.31' versus 'YEARS_TO_BIRTH'

P value = 0.0517 (Wilcoxon-test), Q value = 0.18

Table S234.  Gene #59: 'del_18p11.31' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 37(18P11.31) MUTATED 247 66.1 (12.1)
DEL PEAK 37(18P11.31) WILD-TYPE 200 67.9 (14.1)

Figure S234.  Get High-res Image Gene #59: 'del_18p11.31' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_18p11.31' versus 'PATHOLOGIC_STAGE'

P value = 0.00019 (Fisher's exact test), Q value = 0.0042

Table S235.  Gene #59: 'del_18p11.31' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 37(18P11.31) MUTATED 37 0 11 66 3 1 7 6 36 22 34 16 1
DEL PEAK 37(18P11.31) WILD-TYPE 37 1 18 66 7 0 13 2 23 19 11 1 1

Figure S235.  Get High-res Image Gene #59: 'del_18p11.31' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_18p11.31' versus 'PATHOLOGY_N_STAGE'

P value = 0.0105 (Fisher's exact test), Q value = 0.062

Table S236.  Gene #59: 'del_18p11.31' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 37(18P11.31) MUTATED 130 70 47
DEL PEAK 37(18P11.31) WILD-TYPE 132 35 35

Figure S236.  Get High-res Image Gene #59: 'del_18p11.31' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_18p11.31' versus 'PATHOLOGY_M_STAGE'

P value = 1.47e-05 (Fisher's exact test), Q value = 0.00055

Table S237.  Gene #59: 'del_18p11.31' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 37(18P11.31) MUTATED 165 51
DEL PEAK 37(18P11.31) WILD-TYPE 163 13

Figure S237.  Get High-res Image Gene #59: 'del_18p11.31' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_18p11.31' versus 'HISTOLOGICAL_TYPE'

P value = 2.97e-11 (Fisher's exact test), Q value = 1.3e-08

Table S238.  Gene #59: 'del_18p11.31' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 37(18P11.31) MUTATED 233 10
DEL PEAK 37(18P11.31) WILD-TYPE 149 52

Figure S238.  Get High-res Image Gene #59: 'del_18p11.31' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_18p11.31' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0304 (Wilcoxon-test), Q value = 0.13

Table S239.  Gene #59: 'del_18p11.31' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 37(18P11.31) MUTATED 234 2.2 (4.0)
DEL PEAK 37(18P11.31) WILD-TYPE 190 2.0 (4.9)

Figure S239.  Get High-res Image Gene #59: 'del_18p11.31' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_18q12.2' versus 'YEARS_TO_BIRTH'

P value = 0.0258 (Wilcoxon-test), Q value = 0.12

Table S240.  Gene #60: 'del_18q12.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 38(18Q12.2) MUTATED 272 66.0 (12.4)
DEL PEAK 38(18Q12.2) WILD-TYPE 175 68.3 (14.0)

Figure S240.  Get High-res Image Gene #60: 'del_18q12.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_18q12.2' versus 'PATHOLOGIC_STAGE'

P value = 0.00122 (Fisher's exact test), Q value = 0.013

Table S241.  Gene #60: 'del_18q12.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 38(18Q12.2) MUTATED 38 0 16 70 3 1 11 8 37 28 36 14 1
DEL PEAK 38(18Q12.2) WILD-TYPE 36 1 13 62 7 0 9 0 22 13 9 3 1

Figure S241.  Get High-res Image Gene #60: 'del_18q12.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_18q12.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.0011 (Fisher's exact test), Q value = 0.013

Table S242.  Gene #60: 'del_18q12.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 38(18Q12.2) MUTATED 140 74 58
DEL PEAK 38(18Q12.2) WILD-TYPE 122 31 24

Figure S242.  Get High-res Image Gene #60: 'del_18q12.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_18q12.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.00114 (Fisher's exact test), Q value = 0.013

Table S243.  Gene #60: 'del_18q12.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 38(18Q12.2) MUTATED 191 51
DEL PEAK 38(18Q12.2) WILD-TYPE 137 13

Figure S243.  Get High-res Image Gene #60: 'del_18q12.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_18q12.2' versus 'HISTOLOGICAL_TYPE'

P value = 9.05e-11 (Fisher's exact test), Q value = 2.3e-08

Table S244.  Gene #60: 'del_18q12.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 38(18Q12.2) MUTATED 255 14
DEL PEAK 38(18Q12.2) WILD-TYPE 127 48

Figure S244.  Get High-res Image Gene #60: 'del_18q12.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_18q12.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00262 (Wilcoxon-test), Q value = 0.024

Table S245.  Gene #60: 'del_18q12.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 38(18Q12.2) MUTATED 258 2.3 (4.6)
DEL PEAK 38(18Q12.2) WILD-TYPE 166 1.7 (4.2)

Figure S245.  Get High-res Image Gene #60: 'del_18q12.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_18q21.2' versus 'YEARS_TO_BIRTH'

P value = 0.0488 (Wilcoxon-test), Q value = 0.18

Table S246.  Gene #61: 'del_18q21.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 447 66.9 (13.1)
DEL PEAK 39(18Q21.2) MUTATED 286 66.2 (12.3)
DEL PEAK 39(18Q21.2) WILD-TYPE 161 68.3 (14.2)

Figure S246.  Get High-res Image Gene #61: 'del_18q21.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_18q21.2' versus 'PATHOLOGIC_STAGE'

P value = 8e-05 (Fisher's exact test), Q value = 0.0021

Table S247.  Gene #61: 'del_18q21.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 39(18Q21.2) MUTATED 40 0 17 72 3 1 11 8 40 31 38 15 2
DEL PEAK 39(18Q21.2) WILD-TYPE 34 1 12 60 7 0 9 0 19 10 7 2 0

Figure S247.  Get High-res Image Gene #61: 'del_18q21.2' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_18q21.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.00011 (Fisher's exact test), Q value = 0.0027

Table S248.  Gene #61: 'del_18q21.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 39(18Q21.2) MUTATED 145 78 63
DEL PEAK 39(18Q21.2) WILD-TYPE 117 27 19

Figure S248.  Get High-res Image Gene #61: 'del_18q21.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_18q21.2' versus 'PATHOLOGY_M_STAGE'

P value = 8.66e-05 (Fisher's exact test), Q value = 0.0022

Table S249.  Gene #61: 'del_18q21.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 39(18Q21.2) MUTATED 199 55
DEL PEAK 39(18Q21.2) WILD-TYPE 129 9

Figure S249.  Get High-res Image Gene #61: 'del_18q21.2' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_18q21.2' versus 'GENDER'

P value = 0.0393 (Fisher's exact test), Q value = 0.16

Table S250.  Gene #61: 'del_18q21.2' versus Clinical Feature #7: 'GENDER'

nPatients FEMALE MALE
ALL 213 236
DEL PEAK 39(18Q21.2) MUTATED 125 161
DEL PEAK 39(18Q21.2) WILD-TYPE 88 75

Figure S250.  Get High-res Image Gene #61: 'del_18q21.2' versus Clinical Feature #7: 'GENDER'

'del_18q21.2' versus 'HISTOLOGICAL_TYPE'

P value = 1.07e-10 (Fisher's exact test), Q value = 2.3e-08

Table S251.  Gene #61: 'del_18q21.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 39(18Q21.2) MUTATED 267 16
DEL PEAK 39(18Q21.2) WILD-TYPE 115 46

Figure S251.  Get High-res Image Gene #61: 'del_18q21.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_18q21.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 8.37e-05 (Wilcoxon-test), Q value = 0.0022

Table S252.  Gene #61: 'del_18q21.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 39(18Q21.2) MUTATED 272 2.4 (4.6)
DEL PEAK 39(18Q21.2) WILD-TYPE 152 1.6 (4.1)

Figure S252.  Get High-res Image Gene #61: 'del_18q21.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_18q22.1' versus 'PATHOLOGIC_STAGE'

P value = 4e-05 (Fisher's exact test), Q value = 0.0013

Table S253.  Gene #62: 'del_18q22.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 40(18Q22.1) MUTATED 40 0 18 72 3 1 10 8 39 31 38 15 2
DEL PEAK 40(18Q22.1) WILD-TYPE 34 1 11 60 7 0 10 0 20 10 7 2 0

Figure S253.  Get High-res Image Gene #62: 'del_18q22.1' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_18q22.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00019 (Fisher's exact test), Q value = 0.0042

Table S254.  Gene #62: 'del_18q22.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 40(18Q22.1) MUTATED 146 76 63
DEL PEAK 40(18Q22.1) WILD-TYPE 116 29 19

Figure S254.  Get High-res Image Gene #62: 'del_18q22.1' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_18q22.1' versus 'PATHOLOGY_M_STAGE'

P value = 5.17e-05 (Fisher's exact test), Q value = 0.0015

Table S255.  Gene #62: 'del_18q22.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 40(18Q22.1) MUTATED 198 55
DEL PEAK 40(18Q22.1) WILD-TYPE 130 9

Figure S255.  Get High-res Image Gene #62: 'del_18q22.1' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_18q22.1' versus 'GENDER'

P value = 0.031 (Fisher's exact test), Q value = 0.13

Table S256.  Gene #62: 'del_18q22.1' versus Clinical Feature #7: 'GENDER'

nPatients FEMALE MALE
ALL 213 236
DEL PEAK 40(18Q22.1) MUTATED 124 161
DEL PEAK 40(18Q22.1) WILD-TYPE 89 75

Figure S256.  Get High-res Image Gene #62: 'del_18q22.1' versus Clinical Feature #7: 'GENDER'

'del_18q22.1' versus 'HISTOLOGICAL_TYPE'

P value = 1.29e-11 (Fisher's exact test), Q value = 1.1e-08

Table S257.  Gene #62: 'del_18q22.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 40(18Q22.1) MUTATED 267 15
DEL PEAK 40(18Q22.1) WILD-TYPE 115 47

Figure S257.  Get High-res Image Gene #62: 'del_18q22.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_18q22.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000261 (Wilcoxon-test), Q value = 0.0053

Table S258.  Gene #62: 'del_18q22.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 40(18Q22.1) MUTATED 271 2.4 (4.6)
DEL PEAK 40(18Q22.1) WILD-TYPE 153 1.6 (4.1)

Figure S258.  Get High-res Image Gene #62: 'del_18q22.1' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_19p13.3' versus 'PATHOLOGIC_STAGE'

P value = 0.00228 (Fisher's exact test), Q value = 0.022

Table S259.  Gene #63: 'del_19p13.3' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 41(19P13.3) MUTATED 8 0 1 11 1 0 5 2 5 13 10 4 1
DEL PEAK 41(19P13.3) WILD-TYPE 66 1 28 121 9 1 15 6 54 28 35 13 1

Figure S259.  Get High-res Image Gene #63: 'del_19p13.3' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_19p13.3' versus 'PATHOLOGY_N_STAGE'

P value = 6e-05 (Fisher's exact test), Q value = 0.0017

Table S260.  Gene #63: 'del_19p13.3' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 41(19P13.3) MUTATED 23 16 24
DEL PEAK 41(19P13.3) WILD-TYPE 239 89 58

Figure S260.  Get High-res Image Gene #63: 'del_19p13.3' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_19p13.3' versus 'PATHOLOGY_M_STAGE'

P value = 0.0285 (Fisher's exact test), Q value = 0.13

Table S261.  Gene #63: 'del_19p13.3' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 41(19P13.3) MUTATED 40 15
DEL PEAK 41(19P13.3) WILD-TYPE 288 49

Figure S261.  Get High-res Image Gene #63: 'del_19p13.3' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_19p13.3' versus 'RESIDUAL_TUMOR'

P value = 0.0351 (Fisher's exact test), Q value = 0.14

Table S262.  Gene #63: 'del_19p13.3' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 323 4 25 25
DEL PEAK 41(19P13.3) MUTATED 41 2 7 3
DEL PEAK 41(19P13.3) WILD-TYPE 282 2 18 22

Figure S262.  Get High-res Image Gene #63: 'del_19p13.3' versus Clinical Feature #10: 'RESIDUAL_TUMOR'

'del_19p13.3' versus 'NUMBER_OF_LYMPH_NODES'

P value = 5.08e-06 (Wilcoxon-test), Q value = 0.00027

Table S263.  Gene #63: 'del_19p13.3' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 41(19P13.3) MUTATED 60 4.2 (5.9)
DEL PEAK 41(19P13.3) WILD-TYPE 364 1.7 (4.1)

Figure S263.  Get High-res Image Gene #63: 'del_19p13.3' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_20p12.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0217 (Fisher's exact test), Q value = 0.1

Table S264.  Gene #64: 'del_20p12.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 42(20P12.1) MUTATED 79 5
DEL PEAK 42(20P12.1) WILD-TYPE 303 57

Figure S264.  Get High-res Image Gene #64: 'del_20p12.1' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_21q11.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.0436 (Fisher's exact test), Q value = 0.17

Table S265.  Gene #65: 'del_21q11.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 43(21Q11.2) MUTATED 73 32 35
DEL PEAK 43(21Q11.2) WILD-TYPE 189 73 47

Figure S265.  Get High-res Image Gene #65: 'del_21q11.2' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_21q11.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.00061 (Fisher's exact test), Q value = 0.0087

Table S266.  Gene #65: 'del_21q11.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 43(21Q11.2) MUTATED 129 8
DEL PEAK 43(21Q11.2) WILD-TYPE 253 54

Figure S266.  Get High-res Image Gene #65: 'del_21q11.2' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_21q11.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0555 (Wilcoxon-test), Q value = 0.19

Table S267.  Gene #65: 'del_21q11.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 43(21Q11.2) MUTATED 133 2.9 (6.2)
DEL PEAK 43(21Q11.2) WILD-TYPE 291 1.7 (3.3)

Figure S267.  Get High-res Image Gene #65: 'del_21q11.2' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

'del_22q13.32' versus 'PATHOLOGIC_STAGE'

P value = 0.00101 (Fisher's exact test), Q value = 0.013

Table S268.  Gene #66: 'del_22q13.32' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 74 1 29 132 10 1 20 8 59 41 45 17 2
DEL PEAK 44(22Q13.32) MUTATED 19 0 8 40 1 0 6 6 18 22 25 8 0
DEL PEAK 44(22Q13.32) WILD-TYPE 55 1 21 92 9 1 14 2 41 19 20 9 2

Figure S268.  Get High-res Image Gene #66: 'del_22q13.32' versus Clinical Feature #3: 'PATHOLOGIC_STAGE'

'del_22q13.32' versus 'PATHOLOGY_N_STAGE'

P value = 5e-04 (Fisher's exact test), Q value = 0.008

Table S269.  Gene #66: 'del_22q13.32' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 262 105 82
DEL PEAK 44(22Q13.32) MUTATED 73 45 40
DEL PEAK 44(22Q13.32) WILD-TYPE 189 60 42

Figure S269.  Get High-res Image Gene #66: 'del_22q13.32' versus Clinical Feature #5: 'PATHOLOGY_N_STAGE'

'del_22q13.32' versus 'PATHOLOGY_M_STAGE'

P value = 0.00399 (Fisher's exact test), Q value = 0.031

Table S270.  Gene #66: 'del_22q13.32' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 328 64
DEL PEAK 44(22Q13.32) MUTATED 105 33
DEL PEAK 44(22Q13.32) WILD-TYPE 223 31

Figure S270.  Get High-res Image Gene #66: 'del_22q13.32' versus Clinical Feature #6: 'PATHOLOGY_M_STAGE'

'del_22q13.32' versus 'HISTOLOGICAL_TYPE'

P value = 0.00152 (Fisher's exact test), Q value = 0.016

Table S271.  Gene #66: 'del_22q13.32' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA
ALL 382 62
DEL PEAK 44(22Q13.32) MUTATED 146 11
DEL PEAK 44(22Q13.32) WILD-TYPE 236 51

Figure S271.  Get High-res Image Gene #66: 'del_22q13.32' versus Clinical Feature #9: 'HISTOLOGICAL_TYPE'

'del_22q13.32' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000214 (Wilcoxon-test), Q value = 0.0046

Table S272.  Gene #66: 'del_22q13.32' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 424 2.1 (4.4)
DEL PEAK 44(22Q13.32) MUTATED 149 2.8 (4.9)
DEL PEAK 44(22Q13.32) WILD-TYPE 275 1.7 (4.2)

Figure S272.  Get High-res Image Gene #66: 'del_22q13.32' versus Clinical Feature #11: 'NUMBER_OF_LYMPH_NODES'

Methods & Data
Input

  • Copy number data file = all_lesions.txt from GISTIC pipeline

  • Processed Copy number data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/COAD-TP/22508739/transformed.cor.cli.txt

  • Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/COAD-TP/22506513/COAD-TP.merged_data.txt

  • Number of patients = 449

  • Number of significantly focal cnvs = 66

  • Number of selected clinical features = 13

  • Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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