This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 12 different clustering approaches and 13 clinical features across 626 patients, 61 significant findings detected with P value < 0.05 and Q value < 0.25.
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CNMF clustering analysis on array-based mRNA expression data identified 4 subtypes that correlate to 'TUMOR_TISSUE_SITE', 'PATHOLOGIC_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'HISTOLOGICAL_TYPE', 'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.
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Consensus hierarchical clustering analysis on array-based mRNA expression data identified 3 subtypes that correlate to 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', 'PATHOLOGIC_STAGE', and 'HISTOLOGICAL_TYPE'.
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4 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'TUMOR_TISSUE_SITE', 'PATHOLOGIC_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'HISTOLOGICAL_TYPE', 'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.
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3 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', and 'HISTOLOGICAL_TYPE'.
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CNMF clustering analysis on RPPA data identified 3 subtypes that correlate to 'PATHOLOGY_M_STAGE' and 'RESIDUAL_TUMOR'.
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Consensus hierarchical clustering analysis on RPPA data identified 3 subtypes that correlate to 'PATHOLOGIC_STAGE' and 'RESIDUAL_TUMOR'.
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CNMF clustering analysis on sequencing-based mRNA expression data identified 4 subtypes that correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'HISTOLOGICAL_TYPE', and 'RESIDUAL_TUMOR'.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 7 subtypes that correlate to 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', 'PATHOLOGIC_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.
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4 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', 'PATHOLOGIC_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', and 'RESIDUAL_TUMOR'.
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9 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes correlate to 'YEARS_TO_BIRTH', 'TUMOR_TISSUE_SITE', 'PATHOLOGIC_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'HISTOLOGICAL_TYPE', 'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.
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4 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes correlate to 'TUMOR_TISSUE_SITE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.
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4 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes correlate to 'TUMOR_TISSUE_SITE', 'RADIATION_THERAPY', and 'HISTOLOGICAL_TYPE'.
Clinical Features |
Statistical Tests |
mRNA CNMF subtypes |
mRNA cHierClus subtypes |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RPPA CNMF subtypes |
RPPA cHierClus subtypes |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRseq Mature CNMF subtypes |
MIRseq Mature cHierClus subtypes |
Time to Death | logrank test |
0.358 (0.513) |
0.427 (0.555) |
0.96 (0.985) |
0.945 (0.976) |
0.316 (0.465) |
0.838 (0.902) |
0.0628 (0.146) |
0.392 (0.537) |
0.018 (0.0585) |
0.254 (0.407) |
0.565 (0.686) |
0.379 (0.528) |
YEARS TO BIRTH | Kruskal-Wallis (anova) |
0.414 (0.546) |
0.03 (0.085) |
0.141 (0.261) |
0.000852 (0.00453) |
0.371 (0.521) |
0.128 (0.254) |
0.000821 (0.00453) |
0.000871 (0.00453) |
0.00463 (0.0206) |
0.0129 (0.0457) |
0.122 (0.245) |
0.706 (0.787) |
TUMOR TISSUE SITE | Fisher's exact test |
0.0147 (0.0501) |
0.00132 (0.00664) |
0.0001 (0.000709) |
0.00871 (0.034) |
0.914 (0.973) |
0.171 (0.293) |
0.06 (0.144) |
1e-05 (9.18e-05) |
1e-05 (9.18e-05) |
5e-05 (0.00039) |
1e-05 (9.18e-05) |
7e-05 (0.00052) |
PATHOLOGIC STAGE | Fisher's exact test |
0.00564 (0.0238) |
0.0182 (0.0585) |
1e-05 (9.18e-05) |
0.167 (0.292) |
0.139 (0.261) |
0.00032 (0.00192) |
0.00176 (0.00856) |
0.00013 (0.000845) |
0.00181 (0.00856) |
0.00799 (0.032) |
0.093 (0.196) |
0.923 (0.973) |
PATHOLOGY T STAGE | Fisher's exact test |
0.0726 (0.164) |
0.0724 (0.164) |
0.671 (0.77) |
0.567 (0.686) |
0.681 (0.77) |
0.572 (0.686) |
0.0239 (0.0731) |
0.608 (0.719) |
0.283 (0.433) |
0.241 (0.391) |
0.0481 (0.123) |
0.516 (0.642) |
PATHOLOGY N STAGE | Fisher's exact test |
0.0148 (0.0501) |
0.139 (0.261) |
1e-05 (9.18e-05) |
0.122 (0.245) |
0.196 (0.326) |
0.579 (0.69) |
0.137 (0.261) |
0.0129 (0.0457) |
0.00287 (0.0132) |
0.0404 (0.107) |
0.0297 (0.085) |
0.658 (0.766) |
PATHOLOGY M STAGE | Fisher's exact test |
0.0296 (0.085) |
0.148 (0.27) |
3e-05 (0.000246) |
0.169 (0.293) |
0.0375 (0.101) |
0.402 (0.54) |
0.101 (0.206) |
0.0882 (0.188) |
0.704 (0.787) |
0.037 (0.101) |
0.0112 (0.0425) |
0.518 (0.642) |
GENDER | Fisher's exact test |
0.0546 (0.137) |
0.133 (0.258) |
0.417 (0.546) |
0.391 (0.537) |
0.919 (0.973) |
0.677 (0.77) |
0.416 (0.546) |
0.365 (0.517) |
0.621 (0.729) |
0.759 (0.834) |
0.491 (0.629) |
0.339 (0.489) |
RADIATION THERAPY | Fisher's exact test |
0.94 (0.976) |
0.257 (0.407) |
0.268 (0.418) |
0.149 (0.27) |
0.558 (0.685) |
0.0978 (0.203) |
0.184 (0.309) |
0.496 (0.629) |
0.0627 (0.146) |
0.514 (0.642) |
0.0575 (0.142) |
0.0248 (0.0743) |
HISTOLOGICAL TYPE | Fisher's exact test |
1e-05 (9.18e-05) |
1e-05 (9.18e-05) |
1e-05 (9.18e-05) |
1e-05 (9.18e-05) |
0.0821 (0.18) |
0.258 (0.407) |
2e-05 (0.000173) |
1e-05 (9.18e-05) |
1e-05 (9.18e-05) |
1e-05 (9.18e-05) |
1e-05 (9.18e-05) |
0.00012 (0.000814) |
RESIDUAL TUMOR | Fisher's exact test |
0.0184 (0.0585) |
0.0834 (0.181) |
0.0423 (0.11) |
0.494 (0.629) |
0.00038 (0.0022) |
0.00015 (0.000936) |
1e-05 (9.18e-05) |
1e-05 (9.18e-05) |
1e-05 (9.18e-05) |
0.00723 (0.0297) |
0.281 (0.433) |
0.158 (0.283) |
NUMBER OF LYMPH NODES | Kruskal-Wallis (anova) |
0.0116 (0.0432) |
0.0585 (0.143) |
1.33e-06 (9.18e-05) |
0.398 (0.54) |
0.173 (0.293) |
0.666 (0.77) |
0.209 (0.344) |
0.023 (0.0717) |
0.163 (0.288) |
0.0365 (0.101) |
0.0051 (0.0221) |
0.328 (0.478) |
ETHNICITY | Fisher's exact test |
0.777 (0.842) |
0.743 (0.822) |
0.291 (0.437) |
0.077 (0.172) |
0.291 (0.437) |
0.936 (0.976) |
0.768 (0.837) |
0.298 (0.443) |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 47 | 63 | 68 | 44 |
P value = 0.358 (logrank test), Q value = 0.51
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 211 | 40 | 0.0 - 54.0 (21.0) |
subtype1 | 43 | 9 | 0.0 - 46.6 (24.0) |
subtype2 | 58 | 15 | 1.0 - 52.0 (20.5) |
subtype3 | 66 | 9 | 0.0 - 50.0 (21.5) |
subtype4 | 44 | 7 | 0.0 - 54.0 (21.0) |
P value = 0.414 (Kruskal-Wallis (anova)), Q value = 0.55
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 222 | 69.5 (11.4) |
subtype1 | 47 | 71.1 (11.8) |
subtype2 | 63 | 68.7 (9.1) |
subtype3 | 68 | 68.7 (12.3) |
subtype4 | 44 | 70.1 (12.6) |
P value = 0.0147 (Fisher's exact test), Q value = 0.05
nPatients | COLON | RECTUM |
---|---|---|
ALL | 152 | 68 |
subtype1 | 40 | 7 |
subtype2 | 38 | 25 |
subtype3 | 41 | 25 |
subtype4 | 33 | 11 |
P value = 0.00564 (Fisher's exact test), Q value = 0.024
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|
ALL | 47 | 15 | 65 | 5 | 10 | 3 | 22 | 20 | 33 | 1 |
subtype1 | 8 | 3 | 16 | 3 | 3 | 1 | 4 | 2 | 6 | 0 |
subtype2 | 9 | 3 | 14 | 0 | 2 | 2 | 5 | 11 | 17 | 0 |
subtype3 | 19 | 3 | 20 | 0 | 4 | 0 | 7 | 7 | 8 | 0 |
subtype4 | 11 | 6 | 15 | 2 | 1 | 0 | 6 | 0 | 2 | 1 |
P value = 0.0726 (Fisher's exact test), Q value = 0.16
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 9 | 46 | 148 | 19 |
subtype1 | 1 | 9 | 31 | 6 |
subtype2 | 1 | 12 | 42 | 8 |
subtype3 | 5 | 16 | 47 | 0 |
subtype4 | 2 | 9 | 28 | 5 |
P value = 0.0148 (Fisher's exact test), Q value = 0.05
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 136 | 43 | 43 |
subtype1 | 31 | 6 | 10 |
subtype2 | 29 | 17 | 17 |
subtype3 | 42 | 12 | 14 |
subtype4 | 34 | 8 | 2 |
P value = 0.0296 (Fisher's exact test), Q value = 0.085
nPatients | 0 | 1 |
---|---|---|
ALL | 186 | 34 |
subtype1 | 40 | 6 |
subtype2 | 46 | 17 |
subtype3 | 59 | 8 |
subtype4 | 41 | 3 |
P value = 0.0546 (Fisher's exact test), Q value = 0.14
nPatients | FEMALE | MALE |
---|---|---|
ALL | 106 | 116 |
subtype1 | 29 | 18 |
subtype2 | 33 | 30 |
subtype3 | 28 | 40 |
subtype4 | 16 | 28 |
P value = 0.94 (Fisher's exact test), Q value = 0.98
nPatients | NO | YES |
---|---|---|
ALL | 167 | 13 |
subtype1 | 34 | 2 |
subtype2 | 46 | 3 |
subtype3 | 53 | 5 |
subtype4 | 34 | 3 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 129 | 22 | 58 | 7 |
subtype1 | 29 | 11 | 4 | 2 |
subtype2 | 37 | 1 | 25 | 0 |
subtype3 | 40 | 1 | 21 | 2 |
subtype4 | 23 | 9 | 8 | 3 |
P value = 0.0184 (Fisher's exact test), Q value = 0.059
nPatients | R0 | R1 | R2 |
---|---|---|---|
ALL | 185 | 2 | 29 |
subtype1 | 39 | 0 | 4 |
subtype2 | 46 | 2 | 15 |
subtype3 | 58 | 0 | 8 |
subtype4 | 42 | 0 | 2 |
P value = 0.0116 (Kruskal-Wallis (anova)), Q value = 0.043
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 221 | 2.2 (4.7) |
subtype1 | 47 | 3.2 (6.9) |
subtype2 | 63 | 2.8 (5.4) |
subtype3 | 68 | 1.7 (2.7) |
subtype4 | 43 | 0.8 (2.1) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 52 | 90 | 80 |
P value = 0.427 (logrank test), Q value = 0.56
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 211 | 40 | 0.0 - 54.0 (21.0) |
subtype1 | 50 | 11 | 0.0 - 53.0 (22.5) |
subtype2 | 81 | 16 | 0.9 - 48.0 (21.0) |
subtype3 | 80 | 13 | 0.0 - 54.0 (21.0) |
P value = 0.03 (Kruskal-Wallis (anova)), Q value = 0.085
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 222 | 69.5 (11.4) |
subtype1 | 52 | 72.9 (11.6) |
subtype2 | 90 | 68.3 (10.7) |
subtype3 | 80 | 68.6 (11.8) |
P value = 0.00132 (Fisher's exact test), Q value = 0.0066
nPatients | COLON | RECTUM |
---|---|---|
ALL | 152 | 68 |
subtype1 | 46 | 6 |
subtype2 | 57 | 32 |
subtype3 | 49 | 30 |
P value = 0.0182 (Fisher's exact test), Q value = 0.059
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|
ALL | 47 | 15 | 65 | 5 | 10 | 3 | 22 | 20 | 33 | 1 |
subtype1 | 9 | 3 | 17 | 4 | 3 | 1 | 6 | 2 | 5 | 1 |
subtype2 | 15 | 4 | 23 | 1 | 2 | 1 | 11 | 14 | 19 | 0 |
subtype3 | 23 | 8 | 25 | 0 | 5 | 1 | 5 | 4 | 9 | 0 |
P value = 0.0724 (Fisher's exact test), Q value = 0.16
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 9 | 46 | 148 | 19 |
subtype1 | 1 | 10 | 33 | 8 |
subtype2 | 1 | 18 | 63 | 8 |
subtype3 | 7 | 18 | 52 | 3 |
P value = 0.139 (Fisher's exact test), Q value = 0.26
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 136 | 43 | 43 |
subtype1 | 34 | 9 | 9 |
subtype2 | 46 | 23 | 21 |
subtype3 | 56 | 11 | 13 |
P value = 0.148 (Fisher's exact test), Q value = 0.27
nPatients | 0 | 1 |
---|---|---|
ALL | 186 | 34 |
subtype1 | 45 | 6 |
subtype2 | 70 | 19 |
subtype3 | 71 | 9 |
P value = 0.133 (Fisher's exact test), Q value = 0.26
nPatients | FEMALE | MALE |
---|---|---|
ALL | 106 | 116 |
subtype1 | 30 | 22 |
subtype2 | 44 | 46 |
subtype3 | 32 | 48 |
P value = 0.257 (Fisher's exact test), Q value = 0.41
nPatients | NO | YES |
---|---|---|
ALL | 167 | 13 |
subtype1 | 38 | 2 |
subtype2 | 67 | 3 |
subtype3 | 62 | 8 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 129 | 22 | 58 | 7 |
subtype1 | 27 | 18 | 2 | 3 |
subtype2 | 57 | 0 | 31 | 1 |
subtype3 | 45 | 4 | 25 | 3 |
P value = 0.0834 (Fisher's exact test), Q value = 0.18
nPatients | R0 | R1 | R2 |
---|---|---|---|
ALL | 185 | 2 | 29 |
subtype1 | 45 | 0 | 3 |
subtype2 | 70 | 2 | 17 |
subtype3 | 70 | 0 | 9 |
P value = 0.0585 (Kruskal-Wallis (anova)), Q value = 0.14
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 221 | 2.2 (4.7) |
subtype1 | 52 | 2.8 (6.4) |
subtype2 | 90 | 2.4 (4.7) |
subtype3 | 79 | 1.4 (2.9) |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 215 | 246 | 131 | 22 |
P value = 0.96 (logrank test), Q value = 0.99
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 594 | 128 | 0.0 - 148.0 (22.0) |
subtype1 | 209 | 46 | 0.0 - 139.2 (20.4) |
subtype2 | 237 | 49 | 0.4 - 131.5 (23.6) |
subtype3 | 128 | 29 | 0.0 - 148.0 (24.1) |
subtype4 | 20 | 4 | 0.2 - 52.0 (18.5) |
P value = 0.141 (Kruskal-Wallis (anova)), Q value = 0.26
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 612 | 66.3 (12.8) |
subtype1 | 213 | 67.0 (14.1) |
subtype2 | 246 | 66.7 (11.7) |
subtype3 | 131 | 64.9 (12.6) |
subtype4 | 22 | 62.7 (11.2) |
P value = 1e-04 (Fisher's exact test), Q value = 0.00071
nPatients | COLON | RECTUM |
---|---|---|
ALL | 448 | 162 |
subtype1 | 180 | 35 |
subtype2 | 159 | 83 |
subtype3 | 93 | 38 |
subtype4 | 16 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 104 | 1 | 37 | 172 | 12 | 2 | 24 | 15 | 84 | 55 | 63 | 24 | 2 |
subtype1 | 47 | 1 | 18 | 80 | 7 | 0 | 8 | 2 | 22 | 11 | 8 | 3 | 1 |
subtype2 | 32 | 0 | 10 | 62 | 5 | 2 | 8 | 9 | 43 | 24 | 29 | 13 | 0 |
subtype3 | 21 | 0 | 7 | 27 | 0 | 0 | 6 | 4 | 18 | 17 | 22 | 8 | 0 |
subtype4 | 4 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 1 | 3 | 4 | 0 | 1 |
P value = 0.671 (Fisher's exact test), Q value = 0.77
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 20 | 105 | 417 | 69 |
subtype1 | 9 | 43 | 137 | 25 |
subtype2 | 9 | 34 | 174 | 27 |
subtype3 | 2 | 23 | 92 | 14 |
subtype4 | 0 | 5 | 14 | 3 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 346 | 150 | 115 |
subtype1 | 157 | 32 | 26 |
subtype2 | 117 | 80 | 46 |
subtype3 | 61 | 33 | 37 |
subtype4 | 11 | 5 | 6 |
P value = 3e-05 (Fisher's exact test), Q value = 0.00025
nPatients | 0 | 1 |
---|---|---|
ALL | 453 | 88 |
subtype1 | 175 | 13 |
subtype2 | 178 | 41 |
subtype3 | 88 | 29 |
subtype4 | 12 | 5 |
P value = 0.417 (Fisher's exact test), Q value = 0.55
nPatients | FEMALE | MALE |
---|---|---|
ALL | 289 | 325 |
subtype1 | 106 | 109 |
subtype2 | 112 | 134 |
subtype3 | 64 | 67 |
subtype4 | 7 | 15 |
P value = 0.268 (Fisher's exact test), Q value = 0.42
nPatients | NO | YES |
---|---|---|
ALL | 482 | 29 |
subtype1 | 178 | 6 |
subtype2 | 189 | 15 |
subtype3 | 100 | 7 |
subtype4 | 15 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 382 | 62 | 146 | 13 |
subtype1 | 138 | 41 | 26 | 8 |
subtype2 | 151 | 6 | 81 | 2 |
subtype3 | 80 | 12 | 33 | 3 |
subtype4 | 13 | 3 | 6 | 0 |
P value = 0.0423 (Fisher's exact test), Q value = 0.11
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 446 | 6 | 37 | 29 |
subtype1 | 164 | 2 | 6 | 15 |
subtype2 | 173 | 1 | 17 | 8 |
subtype3 | 94 | 3 | 13 | 4 |
subtype4 | 15 | 0 | 1 | 2 |
P value = 1.33e-06 (Kruskal-Wallis (anova)), Q value = 9.2e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 580 | 2.2 (4.7) |
subtype1 | 201 | 1.5 (4.0) |
subtype2 | 235 | 2.1 (3.7) |
subtype3 | 124 | 3.5 (6.8) |
subtype4 | 20 | 2.6 (4.0) |
P value = 0.777 (Fisher's exact test), Q value = 0.84
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 5 | 352 |
subtype1 | 1 | 125 |
subtype2 | 2 | 139 |
subtype3 | 2 | 75 |
subtype4 | 0 | 13 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 116 | 130 | 145 |
P value = 0.945 (logrank test), Q value = 0.98
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 384 | 87 | 0.2 - 148.0 (22.5) |
subtype1 | 115 | 25 | 0.2 - 148.0 (22.1) |
subtype2 | 127 | 29 | 0.4 - 139.2 (24.7) |
subtype3 | 142 | 33 | 0.9 - 140.4 (21.4) |
P value = 0.000852 (Kruskal-Wallis (anova)), Q value = 0.0045
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 389 | 64.4 (13.0) |
subtype1 | 115 | 61.0 (13.8) |
subtype2 | 130 | 64.1 (12.1) |
subtype3 | 144 | 67.3 (12.6) |
P value = 0.00871 (Fisher's exact test), Q value = 0.034
nPatients | COLON | RECTUM |
---|---|---|
ALL | 293 | 96 |
subtype1 | 84 | 30 |
subtype2 | 88 | 42 |
subtype3 | 121 | 24 |
P value = 0.167 (Fisher's exact test), Q value = 0.29
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 54 | 1 | 21 | 113 | 8 | 2 | 9 | 12 | 62 | 36 | 29 | 23 | 2 |
subtype1 | 13 | 0 | 5 | 35 | 1 | 0 | 2 | 3 | 17 | 13 | 13 | 8 | 0 |
subtype2 | 14 | 0 | 7 | 37 | 2 | 2 | 2 | 7 | 25 | 8 | 9 | 11 | 0 |
subtype3 | 27 | 1 | 9 | 41 | 5 | 0 | 5 | 2 | 20 | 15 | 7 | 4 | 2 |
P value = 0.567 (Fisher's exact test), Q value = 0.69
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 55 | 271 | 51 |
subtype1 | 3 | 11 | 85 | 17 |
subtype2 | 3 | 18 | 92 | 15 |
subtype3 | 5 | 26 | 94 | 19 |
P value = 0.122 (Fisher's exact test), Q value = 0.24
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 213 | 103 | 71 |
subtype1 | 57 | 35 | 24 |
subtype2 | 68 | 40 | 20 |
subtype3 | 88 | 28 | 27 |
P value = 0.169 (Fisher's exact test), Q value = 0.29
nPatients | 0 | 1 |
---|---|---|
ALL | 266 | 53 |
subtype1 | 77 | 20 |
subtype2 | 89 | 20 |
subtype3 | 100 | 13 |
P value = 0.391 (Fisher's exact test), Q value = 0.54
nPatients | FEMALE | MALE |
---|---|---|
ALL | 179 | 212 |
subtype1 | 50 | 66 |
subtype2 | 56 | 74 |
subtype3 | 73 | 72 |
P value = 0.149 (Fisher's exact test), Q value = 0.27
nPatients | NO | YES |
---|---|---|
ALL | 318 | 16 |
subtype1 | 102 | 3 |
subtype2 | 100 | 9 |
subtype3 | 116 | 4 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 251 | 39 | 90 | 6 |
subtype1 | 66 | 17 | 28 | 2 |
subtype2 | 86 | 1 | 42 | 0 |
subtype3 | 99 | 21 | 20 | 4 |
P value = 0.494 (Fisher's exact test), Q value = 0.63
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 259 | 5 | 7 | 29 |
subtype1 | 80 | 1 | 2 | 5 |
subtype2 | 86 | 1 | 2 | 8 |
subtype3 | 93 | 3 | 3 | 16 |
P value = 0.398 (Kruskal-Wallis (anova)), Q value = 0.54
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 357 | 2.3 (4.8) |
subtype1 | 108 | 3.1 (6.7) |
subtype2 | 118 | 1.8 (3.3) |
subtype3 | 131 | 2.0 (4.0) |
P value = 0.743 (Fisher's exact test), Q value = 0.82
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 5 | 338 |
subtype1 | 2 | 104 |
subtype2 | 2 | 113 |
subtype3 | 1 | 121 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 113 | 196 | 180 |
P value = 0.316 (logrank test), Q value = 0.46
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 476 | 105 | 0.0 - 140.4 (21.6) |
subtype1 | 108 | 27 | 0.0 - 117.1 (22.0) |
subtype2 | 191 | 46 | 0.4 - 140.4 (22.0) |
subtype3 | 177 | 32 | 0.0 - 135.7 (20.4) |
P value = 0.371 (Kruskal-Wallis (anova)), Q value = 0.52
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 488 | 66.5 (12.7) |
subtype1 | 113 | 67.2 (13.0) |
subtype2 | 195 | 67.0 (12.5) |
subtype3 | 180 | 65.6 (12.8) |
P value = 0.914 (Fisher's exact test), Q value = 0.97
nPatients | COLON | RECTUM |
---|---|---|
ALL | 358 | 131 |
subtype1 | 81 | 32 |
subtype2 | 144 | 52 |
subtype3 | 133 | 47 |
P value = 0.139 (Fisher's exact test), Q value = 0.26
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 75 | 1 | 28 | 147 | 10 | 1 | 22 | 13 | 69 | 43 | 46 | 19 | 2 |
subtype1 | 16 | 1 | 10 | 28 | 1 | 0 | 5 | 1 | 15 | 12 | 12 | 8 | 1 |
subtype2 | 30 | 0 | 13 | 51 | 5 | 1 | 11 | 6 | 29 | 16 | 24 | 5 | 1 |
subtype3 | 29 | 0 | 5 | 68 | 4 | 0 | 6 | 6 | 25 | 15 | 10 | 6 | 0 |
P value = 0.681 (Fisher's exact test), Q value = 0.77
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 81 | 338 | 56 |
subtype1 | 0 | 19 | 80 | 12 |
subtype2 | 6 | 33 | 132 | 24 |
subtype3 | 5 | 29 | 126 | 20 |
P value = 0.196 (Fisher's exact test), Q value = 0.33
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 274 | 122 | 89 |
subtype1 | 59 | 26 | 26 |
subtype2 | 103 | 56 | 36 |
subtype3 | 112 | 40 | 27 |
P value = 0.0375 (Fisher's exact test), Q value = 0.1
nPatients | 0 | 1 |
---|---|---|
ALL | 368 | 67 |
subtype1 | 82 | 22 |
subtype2 | 143 | 29 |
subtype3 | 143 | 16 |
P value = 0.919 (Fisher's exact test), Q value = 0.97
nPatients | FEMALE | MALE |
---|---|---|
ALL | 234 | 255 |
subtype1 | 56 | 57 |
subtype2 | 93 | 103 |
subtype3 | 85 | 95 |
P value = 0.558 (Fisher's exact test), Q value = 0.69
nPatients | NO | YES |
---|---|---|
ALL | 386 | 23 |
subtype1 | 93 | 5 |
subtype2 | 142 | 11 |
subtype3 | 151 | 7 |
P value = 0.0821 (Fisher's exact test), Q value = 0.18
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 313 | 42 | 118 | 10 |
subtype1 | 72 | 9 | 28 | 3 |
subtype2 | 134 | 9 | 46 | 5 |
subtype3 | 107 | 24 | 44 | 2 |
P value = 0.00038 (Fisher's exact test), Q value = 0.0022
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 365 | 3 | 29 | 19 |
subtype1 | 91 | 0 | 9 | 2 |
subtype2 | 123 | 2 | 18 | 11 |
subtype3 | 151 | 1 | 2 | 6 |
P value = 0.173 (Kruskal-Wallis (anova)), Q value = 0.29
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 463 | 2.1 (4.5) |
subtype1 | 110 | 2.2 (3.8) |
subtype2 | 183 | 2.3 (4.5) |
subtype3 | 170 | 1.9 (5.0) |
P value = 0.291 (Fisher's exact test), Q value = 0.44
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 2 | 299 |
subtype1 | 0 | 50 |
subtype2 | 2 | 111 |
subtype3 | 0 | 138 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 236 | 167 | 86 |
P value = 0.838 (logrank test), Q value = 0.9
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 476 | 105 | 0.0 - 140.4 (21.6) |
subtype1 | 233 | 47 | 0.0 - 135.7 (20.6) |
subtype2 | 161 | 43 | 0.9 - 140.4 (22.4) |
subtype3 | 82 | 15 | 0.0 - 88.2 (20.5) |
P value = 0.128 (Kruskal-Wallis (anova)), Q value = 0.25
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 488 | 66.5 (12.7) |
subtype1 | 236 | 65.8 (12.3) |
subtype2 | 166 | 66.6 (12.7) |
subtype3 | 86 | 68.4 (13.8) |
P value = 0.171 (Fisher's exact test), Q value = 0.29
nPatients | COLON | RECTUM |
---|---|---|
ALL | 358 | 131 |
subtype1 | 175 | 61 |
subtype2 | 127 | 40 |
subtype3 | 56 | 30 |
P value = 0.00032 (Fisher's exact test), Q value = 0.0019
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 75 | 1 | 28 | 147 | 10 | 1 | 22 | 13 | 69 | 43 | 46 | 19 | 2 |
subtype1 | 36 | 1 | 6 | 84 | 3 | 0 | 4 | 5 | 35 | 23 | 16 | 13 | 1 |
subtype2 | 28 | 0 | 9 | 47 | 5 | 1 | 12 | 6 | 20 | 16 | 15 | 5 | 1 |
subtype3 | 11 | 0 | 13 | 16 | 2 | 0 | 6 | 2 | 14 | 4 | 15 | 1 | 0 |
P value = 0.572 (Fisher's exact test), Q value = 0.69
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 81 | 338 | 56 |
subtype1 | 5 | 35 | 168 | 26 |
subtype2 | 3 | 33 | 108 | 23 |
subtype3 | 3 | 13 | 62 | 7 |
P value = 0.579 (Fisher's exact test), Q value = 0.69
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 274 | 122 | 89 |
subtype1 | 137 | 54 | 43 |
subtype2 | 92 | 41 | 33 |
subtype3 | 45 | 27 | 13 |
P value = 0.402 (Fisher's exact test), Q value = 0.54
nPatients | 0 | 1 |
---|---|---|
ALL | 368 | 67 |
subtype1 | 180 | 31 |
subtype2 | 125 | 20 |
subtype3 | 63 | 16 |
P value = 0.677 (Fisher's exact test), Q value = 0.77
nPatients | FEMALE | MALE |
---|---|---|
ALL | 234 | 255 |
subtype1 | 111 | 125 |
subtype2 | 78 | 89 |
subtype3 | 45 | 41 |
P value = 0.0978 (Fisher's exact test), Q value = 0.2
nPatients | NO | YES |
---|---|---|
ALL | 386 | 23 |
subtype1 | 195 | 10 |
subtype2 | 126 | 5 |
subtype3 | 65 | 8 |
P value = 0.258 (Fisher's exact test), Q value = 0.41
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 313 | 42 | 118 | 10 |
subtype1 | 147 | 27 | 57 | 4 |
subtype2 | 114 | 11 | 35 | 4 |
subtype3 | 52 | 4 | 26 | 2 |
P value = 0.00015 (Fisher's exact test), Q value = 0.00094
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 365 | 3 | 29 | 19 |
subtype1 | 192 | 1 | 4 | 7 |
subtype2 | 108 | 2 | 13 | 10 |
subtype3 | 65 | 0 | 12 | 2 |
P value = 0.666 (Kruskal-Wallis (anova)), Q value = 0.77
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 463 | 2.1 (4.5) |
subtype1 | 225 | 2.1 (5.0) |
subtype2 | 155 | 2.4 (4.3) |
subtype3 | 83 | 1.7 (3.8) |
P value = 0.077 (Fisher's exact test), Q value = 0.17
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 2 | 299 |
subtype1 | 0 | 173 |
subtype2 | 1 | 96 |
subtype3 | 1 | 30 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 157 | 129 | 132 | 203 |
P value = 0.0628 (logrank test), Q value = 0.15
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 602 | 128 | 0.0 - 148.0 (22.1) |
subtype1 | 153 | 40 | 0.4 - 140.4 (25.2) |
subtype2 | 128 | 19 | 2.5 - 135.7 (23.6) |
subtype3 | 130 | 35 | 0.2 - 148.0 (20.7) |
subtype4 | 191 | 34 | 0.0 - 117.1 (20.0) |
P value = 0.000821 (Kruskal-Wallis (anova)), Q value = 0.0045
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 619 | 66.3 (12.7) |
subtype1 | 157 | 63.6 (12.4) |
subtype2 | 128 | 66.1 (13.3) |
subtype3 | 131 | 65.7 (13.1) |
subtype4 | 203 | 69.0 (11.9) |
P value = 0.06 (Fisher's exact test), Q value = 0.14
nPatients | COLON | RECTUM |
---|---|---|
ALL | 454 | 163 |
subtype1 | 108 | 49 |
subtype2 | 102 | 25 |
subtype3 | 103 | 29 |
subtype4 | 141 | 60 |
P value = 0.00176 (Fisher's exact test), Q value = 0.0086
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 104 | 1 | 38 | 177 | 12 | 2 | 25 | 15 | 84 | 55 | 62 | 24 | 2 |
subtype1 | 23 | 0 | 8 | 39 | 3 | 2 | 2 | 3 | 27 | 12 | 16 | 13 | 0 |
subtype2 | 28 | 1 | 9 | 35 | 1 | 0 | 6 | 4 | 18 | 7 | 7 | 5 | 2 |
subtype3 | 13 | 0 | 5 | 46 | 2 | 0 | 3 | 3 | 18 | 18 | 15 | 5 | 0 |
subtype4 | 40 | 0 | 16 | 57 | 6 | 0 | 14 | 5 | 21 | 18 | 24 | 1 | 0 |
P value = 0.0239 (Fisher's exact test), Q value = 0.073
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 20 | 105 | 423 | 70 |
subtype1 | 6 | 26 | 104 | 19 |
subtype2 | 3 | 29 | 84 | 12 |
subtype3 | 1 | 13 | 95 | 23 |
subtype4 | 10 | 37 | 140 | 16 |
P value = 0.137 (Fisher's exact test), Q value = 0.26
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 352 | 150 | 115 |
subtype1 | 85 | 45 | 24 |
subtype2 | 79 | 32 | 18 |
subtype3 | 67 | 30 | 34 |
subtype4 | 121 | 43 | 39 |
P value = 0.101 (Fisher's exact test), Q value = 0.21
nPatients | 0 | 1 |
---|---|---|
ALL | 460 | 87 |
subtype1 | 103 | 29 |
subtype2 | 89 | 13 |
subtype3 | 93 | 20 |
subtype4 | 175 | 25 |
P value = 0.416 (Fisher's exact test), Q value = 0.55
nPatients | FEMALE | MALE |
---|---|---|
ALL | 290 | 331 |
subtype1 | 69 | 88 |
subtype2 | 62 | 67 |
subtype3 | 56 | 76 |
subtype4 | 103 | 100 |
P value = 0.184 (Fisher's exact test), Q value = 0.31
nPatients | NO | YES |
---|---|---|
ALL | 489 | 30 |
subtype1 | 117 | 10 |
subtype2 | 110 | 5 |
subtype3 | 116 | 3 |
subtype4 | 146 | 12 |
P value = 2e-05 (Fisher's exact test), Q value = 0.00017
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 388 | 62 | 147 | 13 |
subtype1 | 104 | 2 | 49 | 0 |
subtype2 | 80 | 20 | 20 | 4 |
subtype3 | 84 | 19 | 26 | 3 |
subtype4 | 120 | 21 | 52 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 452 | 6 | 36 | 30 |
subtype1 | 98 | 2 | 8 | 10 |
subtype2 | 84 | 2 | 3 | 9 |
subtype3 | 95 | 1 | 4 | 11 |
subtype4 | 175 | 1 | 21 | 0 |
P value = 0.209 (Kruskal-Wallis (anova)), Q value = 0.34
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 586 | 2.2 (4.7) |
subtype1 | 144 | 1.9 (3.8) |
subtype2 | 119 | 1.9 (4.3) |
subtype3 | 122 | 3.1 (6.4) |
subtype4 | 201 | 2.1 (4.3) |
P value = 0.291 (Fisher's exact test), Q value = 0.44
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 5 | 352 |
subtype1 | 4 | 118 |
subtype2 | 0 | 93 |
subtype3 | 1 | 118 |
subtype4 | 0 | 23 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Number of samples | 81 | 86 | 64 | 57 | 90 | 140 | 103 |
P value = 0.392 (logrank test), Q value = 0.54
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 602 | 128 | 0.0 - 148.0 (22.1) |
subtype1 | 80 | 22 | 1.0 - 148.0 (26.0) |
subtype2 | 84 | 16 | 1.0 - 133.2 (21.3) |
subtype3 | 62 | 17 | 0.2 - 135.7 (20.2) |
subtype4 | 57 | 8 | 2.5 - 91.8 (24.1) |
subtype5 | 90 | 23 | 0.4 - 129.3 (22.5) |
subtype6 | 128 | 20 | 0.0 - 117.1 (21.0) |
subtype7 | 101 | 22 | 0.0 - 64.0 (24.0) |
P value = 0.000871 (Kruskal-Wallis (anova)), Q value = 0.0045
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 619 | 66.3 (12.7) |
subtype1 | 81 | 64.2 (13.1) |
subtype2 | 86 | 65.0 (13.4) |
subtype3 | 62 | 64.7 (15.4) |
subtype4 | 57 | 64.7 (12.8) |
subtype5 | 90 | 63.9 (11.6) |
subtype6 | 140 | 68.0 (10.9) |
subtype7 | 103 | 70.8 (12.2) |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON | RECTUM |
---|---|---|
ALL | 454 | 163 |
subtype1 | 59 | 22 |
subtype2 | 73 | 13 |
subtype3 | 60 | 4 |
subtype4 | 32 | 23 |
subtype5 | 59 | 31 |
subtype6 | 88 | 51 |
subtype7 | 83 | 19 |
P value = 0.00013 (Fisher's exact test), Q value = 0.00084
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 104 | 1 | 38 | 177 | 12 | 2 | 25 | 15 | 84 | 55 | 62 | 24 | 2 |
subtype1 | 14 | 0 | 1 | 26 | 2 | 1 | 1 | 2 | 11 | 10 | 5 | 5 | 0 |
subtype2 | 15 | 1 | 6 | 23 | 1 | 0 | 3 | 3 | 14 | 5 | 5 | 3 | 1 |
subtype3 | 13 | 0 | 4 | 28 | 1 | 0 | 1 | 1 | 5 | 6 | 2 | 1 | 1 |
subtype4 | 8 | 0 | 4 | 8 | 1 | 0 | 3 | 3 | 12 | 3 | 6 | 5 | 0 |
subtype5 | 7 | 0 | 3 | 25 | 1 | 1 | 1 | 1 | 17 | 11 | 9 | 9 | 0 |
subtype6 | 28 | 0 | 7 | 37 | 1 | 0 | 8 | 4 | 16 | 14 | 25 | 0 | 0 |
subtype7 | 19 | 0 | 13 | 30 | 5 | 0 | 8 | 1 | 9 | 6 | 10 | 1 | 0 |
P value = 0.608 (Fisher's exact test), Q value = 0.72
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 20 | 105 | 423 | 70 |
subtype1 | 2 | 14 | 55 | 10 |
subtype2 | 5 | 15 | 53 | 12 |
subtype3 | 2 | 11 | 44 | 7 |
subtype4 | 1 | 9 | 40 | 7 |
subtype5 | 0 | 9 | 66 | 13 |
subtype6 | 6 | 30 | 94 | 10 |
subtype7 | 4 | 17 | 71 | 11 |
P value = 0.0129 (Fisher's exact test), Q value = 0.046
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 352 | 150 | 115 |
subtype1 | 45 | 18 | 17 |
subtype2 | 52 | 23 | 11 |
subtype3 | 46 | 9 | 9 |
subtype4 | 26 | 22 | 9 |
subtype5 | 38 | 27 | 22 |
subtype6 | 77 | 34 | 29 |
subtype7 | 68 | 17 | 18 |
P value = 0.0882 (Fisher's exact test), Q value = 0.19
nPatients | 0 | 1 |
---|---|---|
ALL | 460 | 87 |
subtype1 | 58 | 10 |
subtype2 | 57 | 8 |
subtype3 | 47 | 4 |
subtype4 | 34 | 11 |
subtype5 | 60 | 18 |
subtype6 | 113 | 25 |
subtype7 | 91 | 11 |
P value = 0.365 (Fisher's exact test), Q value = 0.52
nPatients | FEMALE | MALE |
---|---|---|
ALL | 290 | 331 |
subtype1 | 38 | 43 |
subtype2 | 41 | 45 |
subtype3 | 29 | 35 |
subtype4 | 18 | 39 |
subtype5 | 43 | 47 |
subtype6 | 68 | 72 |
subtype7 | 53 | 50 |
P value = 0.496 (Fisher's exact test), Q value = 0.63
nPatients | NO | YES |
---|---|---|
ALL | 489 | 30 |
subtype1 | 59 | 3 |
subtype2 | 72 | 2 |
subtype3 | 53 | 1 |
subtype4 | 50 | 4 |
subtype5 | 79 | 5 |
subtype6 | 97 | 10 |
subtype7 | 79 | 5 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 388 | 62 | 147 | 13 |
subtype1 | 56 | 2 | 22 | 0 |
subtype2 | 58 | 14 | 11 | 2 |
subtype3 | 47 | 12 | 3 | 1 |
subtype4 | 29 | 3 | 22 | 1 |
subtype5 | 53 | 6 | 30 | 1 |
subtype6 | 85 | 3 | 50 | 0 |
subtype7 | 60 | 22 | 9 | 8 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 452 | 6 | 36 | 30 |
subtype1 | 46 | 1 | 2 | 8 |
subtype2 | 58 | 0 | 1 | 4 |
subtype3 | 43 | 1 | 1 | 9 |
subtype4 | 34 | 2 | 2 | 2 |
subtype5 | 66 | 0 | 0 | 7 |
subtype6 | 115 | 2 | 22 | 0 |
subtype7 | 90 | 0 | 8 | 0 |
P value = 0.023 (Kruskal-Wallis (anova)), Q value = 0.072
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 586 | 2.2 (4.7) |
subtype1 | 74 | 2.1 (3.2) |
subtype2 | 78 | 1.8 (4.5) |
subtype3 | 57 | 1.4 (3.3) |
subtype4 | 54 | 2.5 (5.1) |
subtype5 | 82 | 3.1 (6.5) |
subtype6 | 138 | 2.2 (4.4) |
subtype7 | 103 | 2.2 (5.1) |
P value = 0.936 (Fisher's exact test), Q value = 0.98
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 5 | 352 |
subtype1 | 1 | 72 |
subtype2 | 2 | 67 |
subtype3 | 1 | 59 |
subtype4 | 0 | 45 |
subtype5 | 1 | 81 |
subtype6 | 0 | 17 |
subtype7 | 0 | 11 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 154 | 95 | 87 | 213 |
P value = 0.018 (logrank test), Q value = 0.059
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 530 | 116 | 0.0 - 148.0 (23.7) |
subtype1 | 151 | 23 | 0.2 - 148.0 (22.0) |
subtype2 | 95 | 27 | 0.4 - 129.3 (22.4) |
subtype3 | 85 | 26 | 0.9 - 140.4 (31.0) |
subtype4 | 199 | 40 | 0.0 - 117.1 (21.0) |
P value = 0.00463 (Kruskal-Wallis (anova)), Q value = 0.021
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 548 | 66.8 (12.7) |
subtype1 | 153 | 65.3 (13.0) |
subtype2 | 95 | 64.9 (13.3) |
subtype3 | 87 | 65.6 (11.5) |
subtype4 | 213 | 69.3 (12.3) |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON | RECTUM |
---|---|---|
ALL | 405 | 140 |
subtype1 | 127 | 27 |
subtype2 | 75 | 19 |
subtype3 | 41 | 44 |
subtype4 | 162 | 50 |
P value = 0.00181 (Fisher's exact test), Q value = 0.0086
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 94 | 1 | 37 | 152 | 10 | 1 | 25 | 11 | 73 | 47 | 57 | 21 | 1 |
subtype1 | 27 | 1 | 7 | 45 | 2 | 1 | 6 | 1 | 28 | 11 | 10 | 7 | 1 |
subtype2 | 11 | 0 | 4 | 25 | 1 | 0 | 1 | 2 | 15 | 12 | 9 | 8 | 0 |
subtype3 | 11 | 0 | 5 | 22 | 1 | 0 | 3 | 5 | 16 | 8 | 9 | 3 | 0 |
subtype4 | 45 | 0 | 21 | 60 | 6 | 0 | 15 | 3 | 14 | 16 | 29 | 3 | 0 |
P value = 0.283 (Fisher's exact test), Q value = 0.43
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 20 | 94 | 376 | 56 |
subtype1 | 6 | 25 | 108 | 14 |
subtype2 | 2 | 11 | 64 | 16 |
subtype3 | 5 | 13 | 63 | 6 |
subtype4 | 7 | 45 | 141 | 20 |
P value = 0.00287 (Fisher's exact test), Q value = 0.013
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 311 | 134 | 100 |
subtype1 | 90 | 41 | 22 |
subtype2 | 44 | 28 | 20 |
subtype3 | 41 | 31 | 15 |
subtype4 | 136 | 34 | 43 |
P value = 0.704 (Fisher's exact test), Q value = 0.79
nPatients | 0 | 1 |
---|---|---|
ALL | 413 | 78 |
subtype1 | 108 | 18 |
subtype2 | 63 | 16 |
subtype3 | 65 | 12 |
subtype4 | 177 | 32 |
P value = 0.621 (Fisher's exact test), Q value = 0.73
nPatients | FEMALE | MALE |
---|---|---|
ALL | 257 | 292 |
subtype1 | 76 | 78 |
subtype2 | 39 | 56 |
subtype3 | 40 | 47 |
subtype4 | 102 | 111 |
P value = 0.0627 (Fisher's exact test), Q value = 0.15
nPatients | NO | YES |
---|---|---|
ALL | 427 | 26 |
subtype1 | 128 | 3 |
subtype2 | 84 | 5 |
subtype3 | 51 | 7 |
subtype4 | 164 | 11 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 347 | 54 | 127 | 10 |
subtype1 | 110 | 16 | 27 | 0 |
subtype2 | 61 | 14 | 17 | 2 |
subtype3 | 39 | 0 | 42 | 2 |
subtype4 | 137 | 24 | 41 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 386 | 6 | 36 | 26 |
subtype1 | 102 | 2 | 2 | 16 |
subtype2 | 61 | 0 | 3 | 7 |
subtype3 | 49 | 2 | 6 | 1 |
subtype4 | 174 | 2 | 25 | 2 |
P value = 0.163 (Kruskal-Wallis (anova)), Q value = 0.29
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 516 | 2.2 (4.7) |
subtype1 | 135 | 1.7 (3.1) |
subtype2 | 88 | 3.1 (7.1) |
subtype3 | 85 | 2.3 (4.5) |
subtype4 | 208 | 2.1 (4.4) |
P value = 0.768 (Fisher's exact test), Q value = 0.84
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 2 | 307 |
subtype1 | 2 | 137 |
subtype2 | 0 | 79 |
subtype3 | 0 | 54 |
subtype4 | 0 | 37 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
---|---|---|---|---|---|---|---|---|---|
Number of samples | 49 | 74 | 30 | 89 | 78 | 55 | 57 | 33 | 84 |
P value = 0.254 (logrank test), Q value = 0.41
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 530 | 116 | 0.0 - 148.0 (23.7) |
subtype1 | 49 | 7 | 0.2 - 124.3 (21.4) |
subtype2 | 73 | 17 | 0.5 - 100.0 (17.9) |
subtype3 | 29 | 6 | 1.0 - 133.2 (30.1) |
subtype4 | 85 | 23 | 0.0 - 148.0 (25.1) |
subtype5 | 76 | 22 | 0.0 - 135.7 (21.5) |
subtype6 | 52 | 8 | 1.0 - 139.2 (19.8) |
subtype7 | 57 | 19 | 1.9 - 140.4 (25.1) |
subtype8 | 28 | 5 | 0.0 - 45.6 (27.0) |
subtype9 | 81 | 9 | 0.9 - 109.3 (24.0) |
P value = 0.0129 (Kruskal-Wallis (anova)), Q value = 0.046
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 548 | 66.8 (12.7) |
subtype1 | 49 | 66.3 (13.1) |
subtype2 | 74 | 62.9 (13.2) |
subtype3 | 30 | 66.8 (11.9) |
subtype4 | 89 | 64.5 (13.1) |
subtype5 | 77 | 70.0 (12.9) |
subtype6 | 55 | 66.0 (12.9) |
subtype7 | 57 | 68.5 (11.8) |
subtype8 | 33 | 70.9 (13.3) |
subtype9 | 84 | 68.0 (10.7) |
P value = 5e-05 (Fisher's exact test), Q value = 0.00039
nPatients | COLON | RECTUM |
---|---|---|
ALL | 405 | 140 |
subtype1 | 43 | 6 |
subtype2 | 57 | 16 |
subtype3 | 23 | 7 |
subtype4 | 59 | 30 |
subtype5 | 69 | 9 |
subtype6 | 41 | 13 |
subtype7 | 34 | 22 |
subtype8 | 29 | 4 |
subtype9 | 50 | 33 |
P value = 0.00799 (Fisher's exact test), Q value = 0.032
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 94 | 1 | 37 | 152 | 10 | 1 | 25 | 11 | 73 | 47 | 57 | 21 | 1 |
subtype1 | 7 | 0 | 3 | 18 | 1 | 0 | 3 | 0 | 8 | 3 | 2 | 0 | 0 |
subtype2 | 9 | 0 | 4 | 25 | 0 | 0 | 0 | 2 | 12 | 10 | 4 | 6 | 0 |
subtype3 | 10 | 0 | 1 | 9 | 2 | 0 | 2 | 0 | 3 | 0 | 2 | 1 | 0 |
subtype4 | 12 | 1 | 3 | 18 | 1 | 1 | 2 | 2 | 13 | 13 | 16 | 4 | 0 |
subtype5 | 16 | 0 | 12 | 20 | 3 | 0 | 7 | 0 | 6 | 8 | 4 | 1 | 0 |
subtype6 | 10 | 0 | 3 | 15 | 1 | 0 | 5 | 2 | 8 | 2 | 7 | 0 | 0 |
subtype7 | 6 | 0 | 1 | 18 | 1 | 0 | 1 | 3 | 7 | 2 | 5 | 5 | 1 |
subtype8 | 5 | 0 | 1 | 12 | 0 | 0 | 2 | 1 | 4 | 1 | 6 | 1 | 0 |
subtype9 | 19 | 0 | 9 | 17 | 1 | 0 | 3 | 1 | 12 | 8 | 11 | 3 | 0 |
P value = 0.241 (Fisher's exact test), Q value = 0.39
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 20 | 94 | 376 | 56 |
subtype1 | 2 | 7 | 37 | 2 |
subtype2 | 1 | 9 | 52 | 12 |
subtype3 | 4 | 6 | 16 | 4 |
subtype4 | 2 | 12 | 63 | 10 |
subtype5 | 1 | 17 | 50 | 10 |
subtype6 | 4 | 10 | 37 | 4 |
subtype7 | 1 | 10 | 41 | 5 |
subtype8 | 2 | 4 | 22 | 5 |
subtype9 | 3 | 19 | 58 | 4 |
P value = 0.0404 (Fisher's exact test), Q value = 0.11
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 311 | 134 | 100 |
subtype1 | 33 | 11 | 4 |
subtype2 | 38 | 20 | 15 |
subtype3 | 22 | 4 | 4 |
subtype4 | 37 | 24 | 26 |
subtype5 | 53 | 11 | 14 |
subtype6 | 31 | 18 | 6 |
subtype7 | 31 | 17 | 9 |
subtype8 | 18 | 9 | 6 |
subtype9 | 48 | 20 | 16 |
P value = 0.037 (Fisher's exact test), Q value = 0.1
nPatients | 0 | 1 |
---|---|---|
ALL | 413 | 78 |
subtype1 | 33 | 2 |
subtype2 | 55 | 9 |
subtype3 | 24 | 3 |
subtype4 | 60 | 20 |
subtype5 | 69 | 5 |
subtype6 | 43 | 7 |
subtype7 | 35 | 11 |
subtype8 | 26 | 7 |
subtype9 | 68 | 14 |
P value = 0.759 (Fisher's exact test), Q value = 0.83
nPatients | FEMALE | MALE |
---|---|---|
ALL | 257 | 292 |
subtype1 | 20 | 29 |
subtype2 | 33 | 41 |
subtype3 | 14 | 16 |
subtype4 | 44 | 45 |
subtype5 | 40 | 38 |
subtype6 | 28 | 27 |
subtype7 | 24 | 33 |
subtype8 | 19 | 14 |
subtype9 | 35 | 49 |
P value = 0.514 (Fisher's exact test), Q value = 0.64
nPatients | NO | YES |
---|---|---|
ALL | 427 | 26 |
subtype1 | 45 | 1 |
subtype2 | 63 | 6 |
subtype3 | 22 | 0 |
subtype4 | 64 | 5 |
subtype5 | 63 | 3 |
subtype6 | 41 | 2 |
subtype7 | 38 | 5 |
subtype8 | 25 | 0 |
subtype9 | 66 | 4 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 347 | 54 | 127 | 10 |
subtype1 | 38 | 5 | 6 | 0 |
subtype2 | 43 | 14 | 15 | 1 |
subtype3 | 21 | 2 | 6 | 1 |
subtype4 | 51 | 7 | 27 | 3 |
subtype5 | 52 | 16 | 6 | 3 |
subtype6 | 39 | 1 | 13 | 0 |
subtype7 | 31 | 2 | 22 | 0 |
subtype8 | 24 | 5 | 2 | 1 |
subtype9 | 48 | 2 | 30 | 1 |
P value = 0.00723 (Fisher's exact test), Q value = 0.03
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 386 | 6 | 36 | 26 |
subtype1 | 34 | 1 | 1 | 4 |
subtype2 | 51 | 0 | 1 | 8 |
subtype3 | 20 | 0 | 1 | 2 |
subtype4 | 55 | 2 | 11 | 2 |
subtype5 | 61 | 1 | 3 | 4 |
subtype6 | 40 | 0 | 4 | 5 |
subtype7 | 27 | 1 | 1 | 1 |
subtype8 | 29 | 0 | 3 | 0 |
subtype9 | 69 | 1 | 11 | 0 |
P value = 0.0365 (Kruskal-Wallis (anova)), Q value = 0.1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 516 | 2.2 (4.7) |
subtype1 | 46 | 1.2 (2.4) |
subtype2 | 64 | 2.4 (4.3) |
subtype3 | 28 | 1.4 (3.2) |
subtype4 | 82 | 2.7 (3.8) |
subtype5 | 76 | 1.8 (3.9) |
subtype6 | 49 | 2.1 (7.3) |
subtype7 | 56 | 2.2 (4.9) |
subtype8 | 33 | 3.0 (6.8) |
subtype9 | 82 | 2.4 (5.0) |
P value = 0.298 (Fisher's exact test), Q value = 0.44
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 2 | 307 |
subtype1 | 1 | 41 |
subtype2 | 0 | 70 |
subtype3 | 0 | 19 |
subtype4 | 0 | 50 |
subtype5 | 0 | 29 |
subtype6 | 1 | 26 |
subtype7 | 0 | 49 |
subtype8 | 0 | 11 |
subtype9 | 0 | 12 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 35 | 40 | 39 | 22 |
P value = 0.565 (logrank test), Q value = 0.69
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 136 | 43 | 0.2 - 140.4 (25.1) |
subtype1 | 35 | 12 | 0.2 - 139.2 (13.3) |
subtype2 | 40 | 13 | 0.4 - 129.3 (28.9) |
subtype3 | 39 | 10 | 4.0 - 140.4 (27.1) |
subtype4 | 22 | 8 | 6.2 - 131.5 (21.9) |
P value = 0.122 (Kruskal-Wallis (anova)), Q value = 0.24
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 135 | 64.9 (12.6) |
subtype1 | 35 | 64.7 (13.7) |
subtype2 | 40 | 62.6 (11.5) |
subtype3 | 39 | 65.0 (13.3) |
subtype4 | 21 | 69.3 (11.0) |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON | RECTUM |
---|---|---|
ALL | 85 | 50 |
subtype1 | 30 | 5 |
subtype2 | 27 | 13 |
subtype3 | 10 | 28 |
subtype4 | 18 | 4 |
P value = 0.093 (Fisher's exact test), Q value = 0.2
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|
ALL | 15 | 7 | 37 | 1 | 1 | 4 | 21 | 15 | 13 | 9 |
subtype1 | 4 | 1 | 11 | 1 | 0 | 1 | 3 | 5 | 2 | 1 |
subtype2 | 1 | 2 | 11 | 0 | 0 | 1 | 7 | 4 | 7 | 5 |
subtype3 | 2 | 1 | 10 | 0 | 1 | 2 | 8 | 4 | 4 | 3 |
subtype4 | 8 | 3 | 5 | 0 | 0 | 0 | 3 | 2 | 0 | 0 |
P value = 0.0481 (Fisher's exact test), Q value = 0.12
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 4 | 16 | 99 | 15 |
subtype1 | 2 | 4 | 23 | 6 |
subtype2 | 0 | 1 | 32 | 5 |
subtype3 | 1 | 4 | 31 | 3 |
subtype4 | 1 | 7 | 13 | 1 |
P value = 0.0297 (Fisher's exact test), Q value = 0.085
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 64 | 39 | 30 |
subtype1 | 20 | 7 | 8 |
subtype2 | 14 | 14 | 10 |
subtype3 | 13 | 15 | 10 |
subtype4 | 17 | 3 | 2 |
P value = 0.0112 (Fisher's exact test), Q value = 0.043
nPatients | 0 | 1 |
---|---|---|
ALL | 87 | 21 |
subtype1 | 21 | 3 |
subtype2 | 23 | 12 |
subtype3 | 24 | 6 |
subtype4 | 19 | 0 |
P value = 0.491 (Fisher's exact test), Q value = 0.63
nPatients | FEMALE | MALE |
---|---|---|
ALL | 58 | 78 |
subtype1 | 14 | 21 |
subtype2 | 21 | 19 |
subtype3 | 14 | 25 |
subtype4 | 9 | 13 |
P value = 0.0575 (Fisher's exact test), Q value = 0.14
nPatients | NO | YES |
---|---|---|
ALL | 108 | 5 |
subtype1 | 26 | 0 |
subtype2 | 37 | 1 |
subtype3 | 25 | 4 |
subtype4 | 20 | 0 |
P value = 1e-05 (Fisher's exact test), Q value = 9.2e-05
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 74 | 9 | 49 | 1 |
subtype1 | 23 | 5 | 5 | 0 |
subtype2 | 24 | 3 | 13 | 0 |
subtype3 | 10 | 0 | 27 | 1 |
subtype4 | 17 | 1 | 4 | 0 |
P value = 0.281 (Fisher's exact test), Q value = 0.43
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 74 | 2 | 2 | 7 |
subtype1 | 19 | 0 | 0 | 0 |
subtype2 | 26 | 0 | 1 | 2 |
subtype3 | 16 | 2 | 1 | 3 |
subtype4 | 13 | 0 | 0 | 2 |
P value = 0.0051 (Kruskal-Wallis (anova)), Q value = 0.022
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 126 | 2.8 (6.2) |
subtype1 | 35 | 2.1 (4.1) |
subtype2 | 37 | 3.6 (8.4) |
subtype3 | 34 | 4.1 (6.5) |
subtype4 | 20 | 0.7 (1.5) |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 63 | 16 | 34 | 23 |
P value = 0.379 (logrank test), Q value = 0.53
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 136 | 43 | 0.2 - 140.4 (25.1) |
subtype1 | 63 | 23 | 0.2 - 100.0 (21.4) |
subtype2 | 16 | 4 | 4.0 - 129.3 (29.6) |
subtype3 | 34 | 10 | 7.2 - 131.5 (26.4) |
subtype4 | 23 | 6 | 0.4 - 140.4 (25.5) |
P value = 0.706 (Kruskal-Wallis (anova)), Q value = 0.79
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 135 | 64.9 (12.6) |
subtype1 | 63 | 64.4 (13.2) |
subtype2 | 16 | 63.1 (13.1) |
subtype3 | 33 | 67.2 (12.4) |
subtype4 | 23 | 64.0 (11.2) |
P value = 7e-05 (Fisher's exact test), Q value = 0.00052
nPatients | COLON | RECTUM |
---|---|---|
ALL | 85 | 50 |
subtype1 | 52 | 11 |
subtype2 | 5 | 10 |
subtype3 | 17 | 17 |
subtype4 | 11 | 12 |
P value = 0.923 (Fisher's exact test), Q value = 0.97
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|
ALL | 15 | 7 | 37 | 1 | 1 | 4 | 21 | 15 | 13 | 9 |
subtype1 | 9 | 3 | 17 | 1 | 0 | 0 | 7 | 8 | 7 | 5 |
subtype2 | 0 | 1 | 5 | 0 | 0 | 1 | 4 | 1 | 2 | 2 |
subtype3 | 4 | 2 | 8 | 0 | 1 | 2 | 7 | 4 | 2 | 1 |
subtype4 | 2 | 1 | 7 | 0 | 0 | 1 | 3 | 2 | 2 | 1 |
P value = 0.516 (Fisher's exact test), Q value = 0.64
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 4 | 16 | 99 | 15 |
subtype1 | 1 | 9 | 42 | 10 |
subtype2 | 0 | 0 | 15 | 1 |
subtype3 | 2 | 5 | 25 | 2 |
subtype4 | 1 | 2 | 17 | 2 |
P value = 0.658 (Fisher's exact test), Q value = 0.77
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 64 | 39 | 30 |
subtype1 | 33 | 14 | 15 |
subtype2 | 6 | 5 | 5 |
subtype3 | 15 | 12 | 7 |
subtype4 | 10 | 8 | 3 |
P value = 0.518 (Fisher's exact test), Q value = 0.64
nPatients | 0 | 1 |
---|---|---|
ALL | 87 | 21 |
subtype1 | 37 | 12 |
subtype2 | 10 | 3 |
subtype3 | 25 | 3 |
subtype4 | 15 | 3 |
P value = 0.339 (Fisher's exact test), Q value = 0.49
nPatients | FEMALE | MALE |
---|---|---|
ALL | 58 | 78 |
subtype1 | 27 | 36 |
subtype2 | 10 | 6 |
subtype3 | 12 | 22 |
subtype4 | 9 | 14 |
P value = 0.0248 (Fisher's exact test), Q value = 0.074
nPatients | NO | YES |
---|---|---|
ALL | 108 | 5 |
subtype1 | 59 | 0 |
subtype2 | 12 | 2 |
subtype3 | 24 | 2 |
subtype4 | 13 | 1 |
P value = 0.00012 (Fisher's exact test), Q value = 0.00081
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 74 | 9 | 49 | 1 |
subtype1 | 43 | 9 | 11 | 0 |
subtype2 | 5 | 0 | 10 | 0 |
subtype3 | 17 | 0 | 16 | 1 |
subtype4 | 9 | 0 | 12 | 0 |
P value = 0.158 (Fisher's exact test), Q value = 0.28
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 74 | 2 | 2 | 7 |
subtype1 | 37 | 0 | 0 | 3 |
subtype2 | 11 | 0 | 1 | 1 |
subtype3 | 15 | 2 | 0 | 1 |
subtype4 | 11 | 0 | 1 | 2 |
P value = 0.328 (Kruskal-Wallis (anova)), Q value = 0.48
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 126 | 2.8 (6.2) |
subtype1 | 59 | 3.1 (7.3) |
subtype2 | 15 | 3.7 (5.6) |
subtype3 | 32 | 3.1 (5.8) |
subtype4 | 20 | 1.2 (2.1) |
-
Cluster data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_mergedClustering/COADREAD-TP/22555066/COADREAD-TP.mergedcluster.txt
-
Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/COADREAD-TP/22506534/COADREAD-TP.merged_data.txt
-
Number of patients = 626
-
Number of clustering approaches = 12
-
Number of selected clinical features = 13
-
Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.