Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.004 0.103 0.557 19.0 -9999.0 0.0 19.0 KIRREL 0.005 0.055 -9999.0 0.0 -0.449 8.0 8.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.004 0.103 -9999.0 0.0 -0.558 19.0 19.0 PLCG1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.001 0.101 -9999.0 0.0 -0.454 23.0 23.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.016 0.06 -9999.0 0.0 -0.521 2.0 2.0 FYN 0.001 0.083 -9999.0 0.0 -0.399 23.0 23.0 mol:Ca2+ 0.006 0.092 -9999.0 0.0 -0.441 23.0 23.0 mol:DAG 0.006 0.092 -9999.0 0.0 -0.443 23.0 23.0 NPHS2 -0.003 0.076 -9999.0 0.0 -0.763 6.0 6.0 mol:IP3 0.006 0.092 -9999.0 0.0 -0.443 23.0 23.0 regulation of endocytosis 0.011 0.079 -9999.0 0.0 -0.372 23.0 23.0 Nephrin/NEPH1/podocin/Cholesterol -0.002 0.092 -9999.0 0.0 -0.451 23.0 23.0 establishment of cell polarity -0.004 0.103 -9999.0 0.0 -0.557 19.0 19.0 Nephrin/NEPH1/podocin/NCK1-2 0.014 0.086 -9999.0 0.0 -0.406 23.0 23.0 Nephrin/NEPH1/beta Arrestin2 0.012 0.08 -9999.0 0.0 -0.376 23.0 23.0 NPHS1 -0.01 0.124 -9999.0 0.0 -0.749 17.0 17.0 Nephrin/NEPH1/podocin 0.003 0.084 -9999.0 0.0 -0.401 23.0 23.0 TJP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.007 0.093 -9999.0 0.0 -0.445 23.0 23.0 CD2AP 0.0 0.07 -9999.0 0.0 -0.395 19.0 19.0 Nephrin/NEPH1/podocin/GRB2 0.007 0.093 -9999.0 0.0 -0.445 23.0 23.0 GRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.005 0.095 -9999.0 0.0 -0.405 26.0 26.0 cytoskeleton organization 0.017 0.075 -9999.0 0.0 -0.354 15.0 15.0 Nephrin/NEPH1 -0.001 0.076 -9999.0 0.0 -0.411 19.0 19.0 Nephrin/NEPH1/ZO-1 0.007 0.085 -9999.0 0.0 -0.462 18.0 18.0