Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.019 0.138 -9999.0 0.0 -0.599 26.0 26.0 IHH 0.007 0.078 -9999.0 0.0 -0.454 16.0 16.0 SHH Np/Cholesterol/GAS1 -0.106 0.206 -9999.0 0.0 -0.489 125.0 125.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.106 0.205 0.485 125.0 -9999.0 0.0 125.0 SMO/beta Arrestin2 0.013 0.094 -9999.0 0.0 -0.506 7.0 7.0 SMO 0.007 0.099 -9999.0 0.0 -0.494 10.0 10.0 AKT1 0.023 0.05 -9999.0 0.0 -0.308 1.0 1.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.004 0.081 -9999.0 0.0 -0.395 26.0 26.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.007 0.097 -9999.0 0.0 -0.487 10.0 10.0 STIL -0.05 0.176 -9999.0 0.0 -0.499 13.0 13.0 DHH N/PTCH2 0.004 0.07 -9999.0 0.0 -0.315 26.0 26.0 DHH N/PTCH1 0.018 0.09 -9999.0 0.0 -0.476 8.0 8.0 PIK3CA 0.012 0.016 -9999.0 0.0 -0.395 1.0 1.0 DHH -0.003 0.075 -9999.0 0.0 -0.395 22.0 22.0 PTHLH 0.015 0.163 -9999.0 0.0 -0.87 14.0 14.0 determination of left/right symmetry 0.007 0.097 -9999.0 0.0 -0.487 10.0 10.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.016 0.161 -9999.0 0.0 -0.858 14.0 14.0 IHH N/Hhip -0.044 0.136 -9999.0 0.0 -0.315 117.0 117.0 DHH N/Hhip -0.045 0.127 -9999.0 0.0 -0.506 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.007 0.097 -9999.0 0.0 -0.487 10.0 10.0 pancreas development -0.063 0.158 -9999.0 0.0 -0.394 116.0 116.0 HHAT 0.009 0.036 -9999.0 0.0 -0.395 5.0 5.0 PI3K 0.018 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.054 0.157 -9999.0 0.0 -0.409 99.0 99.0 somite specification 0.007 0.097 -9999.0 0.0 -0.487 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.057 0.185 -9999.0 0.0 -0.409 123.0 123.0 SHH Np/Cholesterol/PTCH2 -0.074 0.189 -9999.0 0.0 -0.451 124.0 124.0 SHH Np/Cholesterol/Megalin -0.116 0.229 -9999.0 0.0 -0.487 163.0 163.0 SHH -0.097 0.233 -9999.0 0.0 -0.559 125.0 125.0 catabolic process 0.022 0.088 -9999.0 0.0 -0.51 7.0 7.0 SMO/Vitamin D3 -0.046 0.178 -9999.0 0.0 -0.552 11.0 11.0 SHH Np/Cholesterol/Hhip -0.111 0.195 -9999.0 0.0 -0.469 123.0 123.0 LRP2 -0.062 0.217 -9999.0 0.0 -0.751 56.0 56.0 receptor-mediated endocytosis -0.062 0.186 -9999.0 0.0 -0.574 25.0 25.0 SHH Np/Cholesterol/BOC -0.08 0.19 -9999.0 0.0 -0.458 120.0 120.0 SHH Np/Cholesterol/CDO -0.072 0.187 -9999.0 0.0 -0.453 120.0 120.0 mesenchymal cell differentiation 0.111 0.194 0.465 123.0 -9999.0 0.0 123.0 mol:Vitamin D3 -0.054 0.186 -9999.0 0.0 -0.407 123.0 123.0 IHH N/PTCH2 0.012 0.069 -9999.0 0.0 -0.431 10.0 10.0 CDON 0.012 0.016 -9999.0 0.0 -0.395 1.0 1.0 IHH N/PTCH1 0.024 0.089 -9999.0 0.0 -0.515 7.0 7.0 Megalin/LRPAP1 -0.038 0.167 -9999.0 0.0 -0.57 56.0 56.0 PTCH2 0.008 0.061 -9999.0 0.0 -0.751 4.0 4.0 SHH Np/Cholesterol -0.079 0.186 -9999.0 0.0 -0.458 120.0 120.0 PTCH1 0.022 0.088 -9999.0 0.0 -0.512 7.0 7.0 HHIP -0.064 0.158 -9999.0 0.0 -0.395 116.0 116.0