E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.022 0.034 -9999.0 0.0 -0.31 3.0 3.0 KLHL20 0.041 0.07 0.205 29.0 -0.239 8.0 37.0 CYFIP2 0.027 0.016 -9999.0 0.0 -0.36 1.0 1.0 Rac1/GDP 0.071 0.08 0.245 15.0 -9999.0 0.0 15.0 ENAH 0.021 0.035 -9999.0 0.0 -0.31 3.0 3.0 AP1M1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.017 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.007 0.025 -9999.0 0.0 -0.164 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.052 0.05 -9999.0 0.0 -0.193 10.0 10.0 RAPGEF1 0.06 0.082 0.294 10.0 -9999.0 0.0 10.0 CTNND1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.03 0.036 -9999.0 0.0 -0.317 3.0 3.0 CRK 0.06 0.077 -9999.0 0.0 -0.3 1.0 1.0 E-cadherin/gamma catenin/alpha catenin 0.053 0.017 -9999.0 0.0 -0.212 1.0 1.0 alphaE/beta7 Integrin 0.024 0.054 -9999.0 0.0 -0.24 23.0 23.0 IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.051 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.022 0.035 -9999.0 0.0 -0.31 3.0 3.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.004 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.022 0.077 -9999.0 0.0 -0.198 60.0 60.0 PI3K 0.008 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.039 0.014 -9999.0 0.0 -0.252 1.0 1.0 TIAM1 -0.011 0.114 -9999.0 0.0 -0.36 59.0 59.0 E-cadherin(dimer)/Ca2+ 0.063 0.016 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.025 0.045 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.084 0.083 0.265 19.0 -9999.0 0.0 19.0 actin cytoskeleton organization 0.039 0.059 0.174 35.0 -0.178 6.0 41.0 CDC42/GDP 0.079 0.083 0.278 16.0 -9999.0 0.0 16.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.02 0.01 -9999.0 0.0 -0.192 1.0 1.0 ITGB7 0.013 0.074 -9999.0 0.0 -0.36 23.0 23.0 RAC1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.068 0.017 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.048 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.075 0.09 0.314 13.0 -9999.0 0.0 13.0 CDC42/GTP/IQGAP1 0.034 0.015 -9999.0 0.0 -0.209 1.0 1.0 JUP 0.027 0.016 -9999.0 0.0 -0.36 1.0 1.0 p120 catenin/RhoA/GDP 0.093 0.082 0.271 19.0 -9999.0 0.0 19.0 RAC1/GTP/IQGAP1 0.033 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.013 -9999.0 0.0 -0.252 1.0 1.0 RHOA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.017 -9999.0 0.0 -0.36 1.0 1.0 CTNNA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.033 0.047 0.143 40.0 -0.165 5.0 45.0 NME1 0.022 0.057 0.356 2.0 -0.442 8.0 10.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.021 0.034 -9999.0 0.0 -0.31 3.0 3.0 regulation of cell-cell adhesion 0.011 0.016 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.015 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.08 0.072 0.306 5.0 -9999.0 0.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.053 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.037 0.054 0.161 39.0 -0.203 5.0 44.0 VAV2 0.076 0.127 0.412 1.0 -0.621 10.0 11.0 RAP1/GDP 0.09 0.079 0.308 10.0 -9999.0 0.0 10.0 adherens junction assembly 0.02 0.033 -9999.0 0.0 -0.302 3.0 3.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.016 -9999.0 0.0 -0.36 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.046 0.047 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.014 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.014 0.027 -9999.0 0.0 -0.308 2.0 2.0 PIK3CA 0.027 0.016 -9999.0 0.0 -0.36 1.0 1.0 Rac1/GTP -0.002 0.061 -9999.0 0.0 -0.389 8.0 8.0 E-cadherin/beta catenin/alpha catenin 0.054 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.03 0.036 -9999.0 0.0 -0.322 3.0 3.0