Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.027 0.067 0.3 23.0 -0.235 2.0 25.0 KIRREL 0.021 0.048 -9999.0 0.0 -0.376 8.0 8.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.027 0.067 0.236 2.0 -0.3 23.0 25.0 PLCG1 0.016 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.043 0.079 0.229 2.0 -0.232 42.0 44.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.02 0.037 0.204 2.0 -0.222 7.0 9.0 FYN 0.01 0.062 0.282 12.0 -0.207 25.0 37.0 mol:Ca2+ 0.027 0.061 0.221 1.0 -0.236 21.0 22.0 mol:DAG 0.027 0.062 0.225 1.0 -0.237 21.0 22.0 NPHS2 0.013 0.049 -9999.0 0.0 -0.446 6.0 6.0 mol:IP3 0.027 0.062 0.225 1.0 -0.237 21.0 22.0 regulation of endocytosis 0.036 0.054 0.21 2.0 -0.203 18.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.035 0.059 0.211 2.0 -0.234 25.0 27.0 establishment of cell polarity 0.027 0.067 0.235 2.0 -0.3 23.0 25.0 Nephrin/NEPH1/podocin/NCK1-2 0.064 0.063 -9999.0 0.0 -0.244 11.0 11.0 Nephrin/NEPH1/beta Arrestin2 0.037 0.056 0.217 2.0 -0.205 18.0 20.0 NPHS1 0.013 0.076 0.325 2.0 -0.444 15.0 17.0 Nephrin/NEPH1/podocin 0.037 0.054 0.213 2.0 -0.208 25.0 27.0 TJP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.028 0.001 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.028 0.062 0.229 1.0 -0.238 21.0 22.0 CD2AP 0.016 0.066 -9999.0 0.0 -0.36 18.0 18.0 Nephrin/NEPH1/podocin/GRB2 0.05 0.064 0.229 2.0 -0.237 25.0 27.0 GRB2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.011 0.076 0.295 12.0 -0.214 43.0 55.0 cytoskeleton organization 0.009 0.046 0.205 7.0 -0.346 2.0 9.0 Nephrin/NEPH1 0.025 0.047 0.193 2.0 -0.208 22.0 24.0 Nephrin/NEPH1/ZO-1 0.04 0.058 0.224 2.0 -0.245 20.0 22.0