Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.023 0.105 -9999.0 0.0 -0.506 4.0 4.0 IHH 0.034 0.055 -9999.0 0.0 -0.619 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.087 0.166 -9999.0 0.0 -0.309 71.0 71.0 LRPAP1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.087 0.164 0.307 71.0 -9999.0 0.0 71.0 SMO/beta Arrestin2 0.036 0.074 -9999.0 0.0 -0.536 1.0 1.0 SMO 0.025 0.067 -9999.0 0.0 -0.561 1.0 1.0 AKT1 0.01 0.111 -9999.0 0.0 -0.401 2.0 2.0 ARRB2 0.027 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.025 0.067 -9999.0 0.0 -0.553 1.0 1.0 STIL -0.017 0.118 0.369 1.0 -0.363 8.0 9.0 DHH N/PTCH2 0.048 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.045 0.067 -9999.0 0.0 -0.495 1.0 1.0 PIK3CA 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.023 0.103 -9999.0 0.0 -0.885 1.0 1.0 determination of left/right symmetry 0.025 0.067 -9999.0 0.0 -0.553 1.0 1.0 PIK3R1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.023 0.102 -9999.0 0.0 -0.874 1.0 1.0 IHH N/Hhip -0.041 0.186 -9999.0 0.0 -0.405 44.0 44.0 DHH N/Hhip -0.037 0.166 -9999.0 0.0 -0.364 44.0 44.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.025 0.067 -9999.0 0.0 -0.553 1.0 1.0 pancreas development -0.076 0.215 -9999.0 0.0 -0.501 44.0 44.0 HHAT -0.019 0.159 -9999.0 0.0 -0.502 21.0 21.0 PI3K 0.048 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.128 0.242 -9999.0 0.0 -0.486 67.0 67.0 somite specification 0.025 0.067 -9999.0 0.0 -0.553 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.006 0.099 -9999.0 0.0 -0.373 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.001 0.095 -9999.0 0.0 -0.287 20.0 20.0 SHH Np/Cholesterol/Megalin 0.001 0.096 -9999.0 0.0 -0.287 20.0 20.0 SHH -0.018 0.116 0.227 1.0 -0.365 21.0 22.0 catabolic process 0.03 0.07 -9999.0 0.0 -0.546 1.0 1.0 SMO/Vitamin D3 0.007 0.099 -9999.0 0.0 -0.496 1.0 1.0 SHH Np/Cholesterol/Hhip -0.059 0.162 -9999.0 0.0 -0.322 54.0 54.0 LRP2 0.032 0.024 -9999.0 0.0 -0.325 1.0 1.0 receptor-mediated endocytosis 0.003 0.098 -9999.0 0.0 -0.459 1.0 1.0 SHH Np/Cholesterol/BOC 0.003 0.093 -9999.0 0.0 -0.288 19.0 19.0 SHH Np/Cholesterol/CDO 0.001 0.095 -9999.0 0.0 -0.287 20.0 20.0 mesenchymal cell differentiation 0.059 0.161 0.32 54.0 -9999.0 0.0 54.0 mol:Vitamin D3 0.011 0.107 0.386 1.0 -0.374 3.0 4.0 IHH N/PTCH2 0.049 0.035 -9999.0 0.0 -0.385 1.0 1.0 CDON 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.038 0.073 -9999.0 0.0 -0.553 1.0 1.0 Megalin/LRPAP1 0.047 0.021 -9999.0 0.0 -0.224 1.0 1.0 PTCH2 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.011 0.091 -9999.0 0.0 -0.287 20.0 20.0 PTCH1 0.03 0.07 -9999.0 0.0 -0.548 1.0 1.0 HHIP -0.076 0.216 -9999.0 0.0 -0.502 44.0 44.0